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Dissertations / Theses on the topic 'Antisense nucleic acids'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

Abbas, Sahar. "Design and synthesis of backbone-modified nucleic acids." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368273.

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2

Bijapur, Jeevan. "Factors affecting the stability of nucleic acids." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299497.

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3

Slaitas, Andis. "Development of a new PNA analogue as a potential antisense drug and tool for life-science studies /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-642-1/.

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4

Dryselius, Rikard. "Bacterial gene expression inhibition with antisense peptide nucleic acids /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-338-8/.

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5

Dysko, Anna Monika. "Synthesis and properties of oligonucleotides containing triazole backbone linkages and 2'-modifications for therapeutic applications." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:20fc1203-9751-4654-b497-5f4d97f874a1.

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Antisense oligonucleotides are short strands of DNA, which bind to their complementary mRNA target to prevent protein translation. Although conceptually appealing, for their practical use as drugs, these oligonucleotides must have better cellular uptake, resistance to enzymatic degradation, and target selectivity. In this work, new synthetic chemistry is established to prepare a novel group of chemically modified oligonucleotides. The anionic phosphodiester backbone is partially replaced with a neutral triazole and, at the same time, the 2'-position of the ribose sugar is functionalised with p

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6

Lewis, Karen Jane. "Biodegradable polymers for the sustained release of antisense nucleic acids." Thesis, Aston University, 1996. http://publications.aston.ac.uk/11054/.

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Antisense oligodeoxynucleotides can selectively inhibit individual gene expression provided they remain stable at the target site for a sufficient period of time. Thus, the efficacy of antisense oligodeoxynucleotides may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for the oligodeoxynucleotides and ribozymes. Polymers such as polylactide, polyglycolide, polyhydroxybutyr

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7

Dong, Shuzhi Dong Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4' II. Studies toward the enantioselective synthesis of pestalotiopsin A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174627553.

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8

Silvester, Nicole Cherie. "Terminal Modifications of PNA and Their Use in Diagnostic and Antisense Technologies." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/366991.

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Peptide nucleic acids (PNA) are analogues of DNA that bind to DNA and RNA via Watson-Crick base-pairing rules. Due to the lack of a negatively-charged backbone, hybridisation of PNA to DNA or RNA occurs without electrostatic repulsion thus binding is typically stronger and more rapid than when traditional DNA probes are used. This is reflected in the increased melting temperature (Tm) of the conjugates. These properties, as well as the chemical and biological stability of PNA, make these molecules attractive for use in diagnostic and therapeutic applications. Amino acids are routinely conjugat

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9

Xu, Jian, and 徐堅. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220150.

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10

Xu, Jian. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19918884.

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11

McCracken, Meredith A. "Role of protein kinase C isoforms in human breast tumor cell survival." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2441.

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Thesis (Ph. D.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains xii, 161 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 140-158).

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12

Potter, Felicity Johnson. "A study of the alternative oxidase (AOX) pathway in wild-type Arabidopsis thaliana and the production of an inducidble (aox 1) antisense plant /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09php866.pdf.

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13

Svahn, Mathias G. "DNA analogs for the purpose of gene therapy /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-290-3/.

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14

Chiu, Shih-Jiuan. "Receptor-mediated DNA-based therapeutics delivery." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127403022.

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15

Rogell, Birgit [Verfasser], and Anne [Akademischer Betreuer] Ephrussi. "Exploring the biology of RNPs: specific capture of RNPs using antisense locked nucleic acids / Birgit Rogell ; Betreuer: Anne Ephrussi." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177688379/34.

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16

Raponi, Mitch Biochemistry &amp Molecular Genetics UNSW. "Antisense RNA-mediated gene silencing in fission yeast." Awarded by:University of New South Wales. Biochemistry and Molecular Genetics, 2001. http://handle.unsw.edu.au/1959.4/18277.

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The major aims of this thesis were to investigate the influence of i) antisense gene location relative to the target gene locus (?????location effect?????), ii) double-stranded RNA (dsRNA) formation, and iii) over-expression of host-encoded proteins on antisense RNA-mediated gene regulation. To test the location effect hypothesis, strains were generated which contained the target lacZ gene at a fixed location and the antisense lacZ gene at various genomic locations including all arms of the three fission yeast chomosomes and in close proximity to the target gene locus. A long inverse-PCR proto

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17

Amer, Ayman Salah-el-deen. "Cytoanalysis of pancreatic B-cells using an avian model, mammalian tissue culture and implications of antisense oligonucleotides transfection /." Huntington, WV : [Marshall University Libraries], 2004. http://www.marshall.edu/etd/descript.asp?ref=474.

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Theses (Ph. D.)--Marshall University, 2004.<br>Title from document title page. Includes abstract. Document formatted into pages: contains xiv, 192 p. including illustrations. Bibliography: p. 157-192.

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18

Shen, Christopher. "Effects of surface chemistry and size on iron oxide nanoparticle delivery of oligonucleotides." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39520.

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The discovery of RNA interference and the increasing understanding of disease genetics have created a new class of potential therapeutics based on oligonucleotides. This therapeutic class includes antisense molecules, small interfering RNA (siRNA), and microRNA modulators such as antagomirs (antisense directed against microRNA) and microRNA mimics, all of which function by altering gene expression at the translational level. While these molecules have the promise of treating a host of diseases from neurological disorders to cancer, a major hurdle is their inability to enter cells on their own,

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19

Dai, Guowei. "Pharmacokinetics,pharmacodynamics and metabolism of BCL-2 antisense phosphorothioate oligonucleotide G3139 (Genasense)." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1110309701.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Document formatted into pages; contains 375 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2006 March 9.

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20

Elmén, Joacim. "Nucleic acid based therapeutic approaches /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-047-8/.

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21

Boutimah, Fatima. "Activité antisens de Peptide nucleic acids (PNAs) couplés à des transporteurs peptidiques." Paris 5, 2009. http://www.theses.fr/2009PA05P613.

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Les PNAs ciblant la région codante d’un ARN messager permettent par stratégie antisens de bloquer l’élongation de la traduction. Avant ce travail, seuls les PNAs riches en thymines et capables de former des triplexes avaient été démontrés capables d’une telle activité. Afin d’élargir la variété de séquences ciblées, nous avons montré que des PNAs polypyrimidiques, formant des duplexes ou des triplexes, arrêtent aussi efficacement l’élongation de la traduction. Ces PNAs AS ciblent la séquence polypurine tract du messager de la protéine intégrase du virus VIH-1. Nous avons montré que cette séque

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22

Chalk, Alistair. "Computational prediction of antisense oligonucleotides and siRNAs /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-376-0/.

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23

Ajmera, Mehul J. "Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)." Scholar Commons, 2007. https://scholarcommons.usf.edu/etd/112.

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Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.

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24

Mei, Ivy Yuhua. "Triple helix formation between a short DNA hairpin molecule and linear single stranded oligonucleotides." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/25346.

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25

Åström, Hans. "Studies on phosphate ester cleavage and development of oligonucleotide based artificial nucleases (OBAN's) /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-935-8/.

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26

Ndeboko, Bénédicte. "Développement de nouvelles stratégies antisens à base de PNAs (Peptide Nucleic Acide) pour le traitement des hépatites B chroniques." Lyon 1, 2006. http://www.theses.fr/2006LYO10246.

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Les insuffisances des traitements actuels des infections à Virus de l’Hépatite B (VHB), orientent la recherche vers le développement de nouvelles stratégies antivirales. Ainsi, nous avons étudié à l’aide du modèle du VHB du canard, la capacité des PNAs (Peptide Nucleic Acids), une nouvelle classe de molécules antisens, à inhiber la réplication virale. Nous avons amélioré la pénétration intracellulaire des PNAs par leur couplage à des peptides perméabilisants (CPPs) et optimisé leur voie d’administration. Nous montrons que la voie intraveineuse est plus efficace que la voie intrapéritonéale. Au

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27

Martin, Amaury Hantz Olivier. "Développement de nouvelles approches antivirales du virus de l'hépatite C basées sur l'utilisation d'interférons-alpha variants et d'antisens de type Peptide Nucleic Acids." [s.l.] : [s.n.], 2007. http://tel.archives-ouvertes.fr/docs/00/13/60/18/PDF/these.pdf.

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28

Martin, Amaury. "Développement de nouvelles approches antivirales du virus de l'hépatite C basées sur l'utilisation d'interférons alpha variants et d'antisens de type Peptide Nucleic Acids." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00136018.

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L'infection par le virus de l'hépatite C (VHC) demeure une cause majeure de cirrhose et de carcinome hépatocellulaire. Compte tenu d'une efficacité encore insuffisante des thérapies actuelles (55% de succès en moyenne), le développement de nouvelles stratégies antivirales reste une priorité. Dans ce contexte, nos travaux ont porté sur l'évaluation de nouveaux variants de l'interféron alpha dans un modèle de réplicon VHC. Nous avons pu identifier un variant, GEA007.1 qui présente une activité anti-VHC supérieure à celle de l'IFN alpha-2b utilisé en clinique associé à une plus grande efficacité

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29

Miner, LeeAnn Holley. "Effects of infusions of antisense oligodeoxynucleotides for glutamic acid decarboxylase into the nucleus accumbens on sustained attention performance in the rat /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942182325419.

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30

Huang, Sung-ben. "Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid." Thesis, 1990. http://hdl.handle.net/1957/37376.

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31

Raponi, Mitch. "Antisense RNA-mediated gene silencing in fission yeast /." 2000. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20020131.041016/index.html.

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32

Nulf, Christopher J. "Peptide nucleic acid (PNA) hybridization to nucleic acid targets." 2004. http://edissertations.library.swmed.edu/pdf/NulfC121504/NulfChristopher.pdf.

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33

"Inhibition of glucose transporter gene expression by antisense nucleic acids in HL-60 cells." 1997. http://library.cuhk.edu.hk/record=b5889215.

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by Judy, Yuet-wa Chan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1997.<br>Includes bibliographical references (leaves 107-111).<br>Acknowledgements --- p.i<br>Contents --- p.ii-iv<br>Abstract --- p.v-vii<br>Abbreviations --- p.ix<br>List of figures and tables --- p.x-xii<br>Chapter Chapter One: --- Introduction --- p.1-20<br>Chapter 1.1 --- Facilitative Glucose Transporter Family (GLUT)<br>Chapter 1.2 --- Sequence and characterization of GLUT<br>Chapter 1.3 --- Overexpression of GLUT 1 in human cancer cells<br>Chapter 1.4 --- Inhibition of gene expression by antisense nucleic

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34

Sundaram, Sumati. "Interplay of polymer and oligonucleotide properties in the nature of antisense effects." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17225.

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35

Potter, Felicity Johnson. "A study of the alternative oxidase (AOX) pathway in wild-type Arabidopsis thaliana and the production of an inducidble (aox 1) antisense plant / by Felicity Johnson Potter." Thesis, 1998. http://hdl.handle.net/2440/19258.

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Bibliography: leaves 175-186.<br>186 leaves : ill. (some col.) ; 30 cm.<br>Aims to examine the AP in A. thaliana and to produce an inducible antisense plant to assist future studies of the role of AOX.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Botany, 1999?

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36

El, Sabahy Mahmoud. "Polymeric micelles as versatile carriers for drugs and nucleic acids." Thèse, 2009. http://hdl.handle.net/1866/3481.

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Le cancer est la principale cause de mortalité au Canada. Les taxanes (e.g. le paclitaxel et le docétaxel (DCTX)) constituent des remèdes efficaces contre une série de tumeurs solides telles que les cancers du sein, du poumon et de l’ovaire. Par ailleurs, des acides nucléiques (e.g. les oligonucléotides antisens (AON) ou les petits ARN interférents (siRNAs)), capables de supprimer sélectivement certains oncogènes impliqués dans la carcinogénèse, sont actuellement étudiés pour traiter une large gamme de cancers. Bien que l’activité des taxanes et des acides nucléiques soit bien établie sur des

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37

Salinas, Hernandez Juan Carlos. "Synthesis of constrained nucleosides." Thèse, 2018. http://hdl.handle.net/1866/21699.

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38

"Study of antisense oligonucleotides against glucose transporter 5 (Glut 5) on human breast cancer cells." 2004. http://library.cuhk.edu.hk/record=b5892179.

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Chung Ka Wing.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (leaves 151-162).<br>Abstracts in English and Chinese.<br>Contents --- p.i<br>Acknowledgements --- p.v<br>Abstract --- p.vi<br>論文摘要 --- p.ix<br>List of Abbreviations --- p.xi<br>List of Figures --- p.xiii<br>List of Tables --- p.xv<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Breast Cancer --- p.2<br>Chapter 1.1.1 --- Incidence Rate of Breast Cancer --- p.2<br>Chapter 1.1.2 --- Risk Factors Lead to Breast Cancer --- p.5<br>Chapter 1.1.3 --- Convention

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39

Giacometti, Robert. "Synthesis of constrained tricyclic nucleosides and the core of nagilactone B." Thèse, 2015. http://hdl.handle.net/1866/13568.

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Cette thèse décrit deux thèmes principaux: 1) la conception, la synthèse, et l'évaluation biophysique des nucléosides tricycliques, et 2) la synthèse de nagilactone B, un produit naturel norditerpenoïde dilactone de la famille de produits naturels “podolactone”. Le premier chapitre décrit la stratégie de design rationnel des nucléosides nommé “restriction conformationnelle double” basée sur les études de modélisation structurales des duplex ADN–ARN modifiés. Cette stratégie implique un blocage du cycle furanose dans une configuration de type N- ou S, et une restriction de la rotation torsio

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40

Silva, Soraia Vanessa Guerreiro da. "Epigenetics and alternative splicing." Master's thesis, 2015. http://hdl.handle.net/10400.1/8419.

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Dissertação de Mestrado, Oncobiologia: Mecanismos Moleculares do Cancro, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2015<br>Epigenética é a área da genética que se foca no estudo das alterações biológicas da célula que não envolvem alterações na sequência de nucleótidos do DNA. Um dos componentes da epigenética que tem vindo a ganhar interesse na comunidade científica são os RNAs longos não codificantes (do inglês long noncoding RNAs - lncRNAs) que são transcritos que contém mais de 200 nucleótidos. Estes não possuem quadros de leitura abertos (do inglês open read

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41

Równicki, Marcin. "Poszukiwanie nowych celów oraz nośników dla antysensownych oligonukleotydów o działaniu antybakteryjnym." Doctoral thesis, 2020. https://depotuw.ceon.pl/handle/item/3650.

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Światowa Organizacja Zdrowia (WHO) umieściła zakażenia powodowane przez antybiotykooporne bakterie Escherichia coli na pierwszym miejscu listy chorób zakaźnych, których zwalczaniu oraz zapobieganiu należy nadać najwyższy priorytet. Pojawienie i rozprzestrzenienie się bakteryjnych szczepów antybiotykoopornych jest istotnym problemem, którego rozwiązanie wymaga zastosowania nowatorskich strategii przeciwbakteryjnych. Syntetyczne antysensowne oligonukleotydy, stosowane do zahamowania procesu syntezy białek niezbędnych do życia bakterii, mogą okazać się pomocne w zwalczaniu zakażeń bakteryjnych. P

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42

Lima, Joana Filipa Torrinha Ferreira. "The use of antisense nucleic acid mimics for suppressing microRNAs involved in Gastric Cancer." Doctoral thesis, 2018. https://hdl.handle.net/10216/111821.

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43

Lima, Joana Filipa Torrinha Ferreira. "The use of antisense nucleic acid mimics for suppressing microRNAs involved in Gastric Cancer." Tese, 2018. https://hdl.handle.net/10216/111821.

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44

Su, Wu [Verfasser]. "Design and synthesis of antisense peptide nucleic acid conjugated MR contrast agents = Design und Synthese von Antisense-Peptid-Nukleinsäure-konjugierten MR-Kontrastmitteln / vorgelegt von Wu Su." 2007. http://d-nb.info/986489328/34.

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