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Dissertations / Theses on the topic 'Antiretroviral agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

陳惠結 and Wai-kit Chan. "The most effective method to improve antiretroviral drug adherence." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40720329.

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Chan, Wai-kit. "The most effective method to improve antiretroviral drug adherence." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40720329.

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3

Terblanche, Lauren Muriel. "The knowledge about HIV/AIDS and antiretroviral treatment of patients receiving antiretroviral therapy." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20131.

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Thesis (MCur)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Many HIV positive patients are on antiretroviral therapy (ART) to assist in decreasing the replication of the HIV virus within the body. Adherence to this medication is important, as non- adherence can have serious repercussions. Therefore, the patients’ knowledge of ART and their disease is crucial in ensuring good adherence. A range of barriers to patient education were suspected by the researcher in this community of Delft. The high influx of patients into the clinic everyday minimized consultation time and thereby dim

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4

Maseko, Batlile Paulos. "Antiretroviral treatment programme outcomes scenarios in South Africa in the next two decades." Thesis, University of Limpopo (Medunsa Campus), 2012. http://hdl.handle.net/10386/1094.

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5

Gaula, M. D. "Drug adverse effects in HIV-infected patients receiving antiretroviral therapy-a pharmacovigilence approach." Thesis, University of Limpopo ( Medunsa Campus), 2011. http://hdl.handle.net/10386/396.

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Thesis (M Med Pharmacy)--University of Limpopo, 2011<br>Most pharmaceutical agents can result in side effects and toxicities that in some instances may be life threatening, especially if there is delay in their recognition. For various reasons it is therefore imperative to study adverse events associated with antiretroviral agents (ARVs). The aim of this study was to study the adverse events in adult HIV-infected patients receiving antiretroviral therapy at a public health treatment site, and to quantify the frequency of adverse events in different population subgroups. A retrospective c

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6

Srasuebkul, Preeyaporn Public Health &amp Community Medicine Faculty of Medicine UNSW. "Evaluating monitoring strategies, short-term disease progression and rate of treatment change in HIV-infected patients commencing antiretroviral therapy in the Asia-Pacific region." Publisher:University of New South Wales. Public Health & Community Medicine, 2008. http://handle.unsw.edu.au/1959.4/41673.

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This thesis assesses factors associated with a number of short and long-term outcomes in HIV-infected patients receiving antiretroviral treatment in Asia. Analyses in this thesis were based on two cohorts of HIV-infected patients; The Treat Asia HIV Observational Database (TAHOD), a multi-centre prospective observational cohort from countries in Asia-Pacific region, and the HIV Netherlands Australia Thailand (HIV-NAT) collaboration cohort, a cohort of patients treated with antiretroviral treatments at HIV-NAT in Bangkok, Thailand. We examined factors associated with time to immunological fail

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7

Nikisi, Joseph. "Access to antiretroviral treatment in the public sector, in Zambia /." Access to E-Thesis, 2005. http://upetd.up.ac.za/thesis/available/etd-04282009-163207/.

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8

Togami, Hiroaki. "Comprehensive in vitro susceptibility analysis of simian retrovirus type 4 to antiretroviral agents." Kyoto University, 2013. http://hdl.handle.net/2433/179351.

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9

Casey, Ryan Edward. "Mouse strain-specific splicing of Apobec3." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/950.

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"Host resolution of viral infection is dependent upon components of the innate and acquired immune system. The mammalian protein Apobec3 plays an important role as part of the immune systemâ€™s innate defenses through its modification of reverse transcribed viral DNA. Recently, Apobec3 was found to directly inhibit HIV-1 and HBV replication through deaminating newly transcribed deoxycytidine residues to deoxyuridine. The ability of mouse and simian Apobec3 variants to inhibit human retroviruses and vice versa highlights the utility of analyzing cross-species homologues. To better understan

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10

Esposito, Francesca. "Impact of highly active antiretroviral therapy (HAART) on body composition and other anthropometric measures of HIV-infected women in a primary healthcare setting in KwaZulu-Natal : a pilot study." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/1886.

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11

Kubashe, Nomachina Theopatra. "Disclosure of HIV status and adherence to antiretroviral therapy." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1174.

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The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) is one of the leading chronic diseases affecting people in South Africa and throughout the world. This study aimed to investigate the effect disclosure of HIV status had on antiretroviral therapy (ART) adherence. A convenience sample of 65 HIV positive adult patients currently taking ART at a public Primary Health Care (PHC) clinic in the Nelson Mandela Metropole was selected. Participation was voluntary and confidentiality was maintained at all times. Data was collected using three tools/techniques: (1) a Patien

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12

Vermeulen, Jacomina Hendrina. "Identifying structural barriers to antiretroviral therapy adherence." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6539.

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Thesis (MA)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The topic of antiretroviral adherence remains a subject of continued importance, as it is associated with positive health outcomes amongst patients attending public healthcare facilities. Available literature on adherence behaviour mainly focuses on the psychological and behavioural barriers, while overlooking the multitude of structural barriers within the patient’s environment affecting the patient’s adherence to antiretroviral treatment and care. The present study provides a unique perspective on adherence behaviour am

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13

Nqabeni, Luxolo. "Development of an antiretroviral solid dosage form using multivariate analysis." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/705.

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The aim of pharmaceutical development is to design a quality product and the manufacturing process to deliver the product in a reproducible manner. The development of a new and generic formulation is based on a large number of experiments. Statistics provides many tools for studying the conditions of formulations and processes and enables us to optimize the same while being able to minimize our experimentation. The purpose of this study was to apply experimental design methodology (DOE) and multivariate analysis to the development and optimization of tablet formulations containing 150 mg lamiv

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14

Moitra, Ethan Herbert James D. "Acceptance-based intervention to promote HIV medication adherence /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3035.

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15

Nyakwezi, Kamugasha Sheila. "The use of anthropometric indices as an alternative guide to initiating antiretroviral therapy (ART) in children at the Mildmay Centre in Uganda /." Link to the online version, 2008. http://hdl.handle.net/10019/1502.

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16

Saal, Wylene Leandri. "The applicability of the theory of planned behaviour in predicting adherence to antiretroviral therapy (ART) among a South African sample." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6821.

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Thesis (MSc)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The primary aim of the study was to determine the applicability of the theory of planned behaviour (TPB) in predicting adherence to ART among South African patients attending public health clinics. The second aim was to determine the relationship between self-reported adherence and viral load. The results from the hierarchical multiple regression analyses revealed that the linear combination of the variables of the TPB significantly explained 12% of the variance in intentions to adhere to ART. Perceived behavioural cont

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17

Aung, Kay Tu Jittima Dhitavat. "Pulmonary tuberculosis treatment outcomes in HIV infected patients on antiretroviral therapy /." Abstract, 2006. http://mulinet3.li.mahidol.ac.th/thesis/2549/cd388/4838793.pdf.

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18

Cantrell, Ronald Alexander. "Diagnosing antiretroviral treatment failure in resource-limited settings." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/cantrell.pdf.

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19

Rojas, Liévano Jhon Fredy. "Nuevas estrategias para mejorar la tolerabilidad del tratamiento antirretroviral y disminuir su impacto sobre las comorbilidades." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668145.

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La infección por el virus de la inmunodeficiencia humana (VIH) continúa siendo un problema importante de salud pública mundial. En 2017 aproximadamente 36,9 millones de personas eran portadoras del VIH (incluidos 1,8 millones de niños), con una prevalencia global del virus del 0,8% entre los adultos. A pesar de que el tratamiento antirretroviral (TAR) es cada vez mejor tolerado y más simple, hasta el 70% de discontinuaciones se debe a intolerancia/toxicidad o conveniencia (datos de la Cohorte ICONA) y en el contexto del envejecimiento de la población las interferencias/interacciones del TAR

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20

Ren, Yuan. "The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3297.

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Background: Tuberculosis (TB) is the most common opportunistic infection in children with human immunodeficiency virus (HIV) infection in developing countries, and co-treatment for HIV infection and TB is frequently indicated. Efavirenz and lopinavir/ritonavir (ratio 1:1) as part of antiretroviral therapy are used in combination with rifampicin-based antitubercular treatment in South African TB/HIV co-infected children. Adult studies show that concomitant rifampicin significantly reduces efavirenz and lopinavir plasma concentrations. However, the pharmacokinetics (PK) of efavirenz and lopinavi

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21

Bergin, Hild. "Cardiovascular side effects of the antiretroviral agents rilpivirine, efavirenz, etravirine and abacavir : possible underlying mechanisms." Thesis, University of Brighton, 2014. https://research.brighton.ac.uk/en/studentTheses/59df6711-f1e9-4190-97ea-31953c1b3661.

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The introduction of highly active antiretroviral therapy (HAART) has dramatically improved the life expectancy of HIV infected individuals. With the increased lifespan, complications associated with HAART are becoming more evident. Together with HIV itself and a higher prevalence of traditional risk factors, the antiretroviral agents are linked to an increase in cardiovascular diseases in the HIV population. In the present in vitro study the direct cardiac effects of a nucleoside reverse transcriptase inhibitor (NRTI) abacavir in combination with palmitic acid or cobalt chloride mimicking a di

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22

Peplinski, Kyle P. "The effects of antiretroviral access on the creation and maintenance of HIV-seropositive identity." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-07122008-133945/.

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Thesis (M.A.)--Georgia State University, 2008.<br>Title from file title page. Cassandra White, committee chair; Kathryn A. Kozaitis, Susan McCombie, committee members. Electronic text (95 p.) : digital, PDF file. Description based on contents viewed Sept. 29, 2008. Includes bibliographical references (p. 90-94).

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23

Waltje, Andrea H. "Predictors of nonadherence to antiretroviral therapies in HIV-infected older adults." Ohio : Ohio University, 2003. http://www.ohiolink.edu/etd/view.cgi?ohiou1067542971.

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24

Tiraboschi, Juan Manuel. "Penetration and antiviral activity of antiretroviral drugs in the Central Nervous System." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396308.

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INTRODUCTION: With successful treatment and near-normal life expectancy of people living with HIV, the focus of care has shifted towards minimizing toxicity from long term exposure to antiretrovirals (ARVs) and preventing co-morbidities. The prevalence of neurocognitive abnormalities has been reported to remain high, including in patients treated with cART. A low level viral replication in the central nervous system (CNS) may persist even in patients presenting with HIV-1 suppression in plasma, leading to local inflammation, neuronal damage and a poorer neuropsychological performance. A

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25

Wahba, Alexander. "Modified nucleotides and nucleic acids for the discovery of antiretroviral agents targeting HIV-1 reverse transcriptase." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=94986.

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The reverse transcriptase (RT) of the human immunodeficiency virus (HIV) has both polymerase and ribonuclease H (RNase H) activity, and is a key enzyme in the HIV life cycle as it converts the viral RNA genome into double-stranded DNA. A series of studies built around the theme of chemically modified nucleic acids are described in order to: (1) better understand the biochemical processes of reverse transcription in HIV-1, (2) synthesize antiretroviral agents directed to novel targets on HIV-1 (RT), and (3) develop screening methods incorporating fluorescent nucleobase analogues to uncover new

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26

Nikisi, Joseph. "Access to antiretroviral treatment in the public sector, in Zambia." Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-04282009-163207.

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27

Berbaum, Jennifer Bentz Joe. "Investigating the role of nuclear receptors in HIV/HAART-associated dyslipidemic lipodystrophy /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1759.

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28

Wu, Lucy Mimi. "Antiretroviral prophylaxis for prevention of mother to child transmission of HIV through breastfeeding: asystematic review and meta-analysis of infant treatment regimens." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48426581.

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A systematic review and meta-analysis was conducted to evaluate the efficacy of different infant antiretroviral (ARV) prophylaxis regimens for prevention of mother to child transmission (MTCT) of human immunodeficiency virus (HIV) infection in breastfeeding infants who were born to HIV positive mothers but were HIV uninfected at birth. The systematic review of the literature published during January 2000 to April 2012 resulted in ten randomized and controlled clinical studies which met the study inclusion criteria. Two datasets were identified from the ten selected clinical trials. One datas

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29

Wu, Charlotte Audris. "Qualitative Assessment of Adherence to Antiretroviral Therapy among Chinese Intravenous Drug Users." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08282007-153749/.

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Injection drug users (IDUs) account for an estimated 44% of people living with HIV/AIDS in China and are the major driving force behind the expanding epidemic. Developing effective antiretroviral therapy (ART) adherence interventions in the Chinese IDU population is a major challenge. In conjunction with ART scale-up in Yunnan province, our goal was to gather patient perspectives on ART and ideas for feasible adherence support. Between December 2005 and March 2006, eight focus groups with a total of 55 HIV positive IDUs were conducted at three sites in Yunnan to ascertain ART knowledge, barrie

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30

Innes, Steven Eugene Vere. "Lipoatrophy in HIV-infected children on antiretroviral therapy." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79864.

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Thesis (PhD)--Stellenbosch University, 2013.<br>Bibliography<br>ENGLISH ABSTRACT: Introduction: Lipoatrophy is a common adverse effect of stavudine and this effect is strongly dose-dependent. Stavudine remains the most commonly used paediatric antiretroviral drug in sub-Saharan Africa, yet when the current study began in 2009, the prevalence and severity of lipoatrophy in children on antiretroviral therapy in sub-Saharan Africa had never been studied. The development of lipoatrophy may have serious and far-reaching consequences for patients and their families. The off-label stavudine dosing m

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31

Mokheseng, Mamolise. "The management of antiretroviral drug distribution in the Qwaqwa District." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1016077.

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The supply of Antiretrovirals (ARVs) to HIV/AIDS patients in most of the provinces in South Africa is hindered by various factors such as ineffective and inefficient drug procurement, and drug distribution systems. In the QwaQwa district in the Free State Province, a major barrier to the consistent supply of Highly Active Antiretroviral Treatment was identified to be the lack of an effective and efficient ARV drug distribution system. This resulted in major drug supply shortages in the QwaQwa district. A continuous, uninterrupted supply of ARVs to HIV/AIDS patients is critical to avoid drug re

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32

Knox, Kirstine A. "Antiretroviral agents and HIV-1 disease : analysis of in vitro phenotypic and functional markers of zidovudine therapy." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46869.

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33

Adebanjo, Adefolarin Babafemi. "Factors affecting response to antiretroviral agents at one year in an HIV cohort at Roma Hospital, Lesotho." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/24507.

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Objective: The objective of this retrospective cohort study is to assess whether demographic and anthropometric parameters, laboratory tests, co-morbidity, co-infection, treatment regimen, IRIS and adherence predict response to HAART as measured by CD4 count, weight gain and functional status in a cohort of patients in Roma, the Kingdom of Lesotho. Method: Data were collected from a computerised database of the Antiretroviral Centre of the hospital. A cohort of 300 subjects was identified from hospital records from January 2007. Each of these subjects was followed up over a period of 12 months

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34

Das, C. R. "Causes of non-adherence to antiretroviral therapy in Wellness Clinic, Tshepong Hospital, Klerksdorp." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/97161.

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ENGLISH ABSTRACT: HIV/AIDS is the leading cause of death in Sub-Saharan Africa. According to 2001 estimates, there are 28.5 million people living with HIV in Africa, comprising more than 70% of the world’s HIV-infected population. HIV/AIDS remains one of the most important social and public health threats in Sub-Saharan Africa. UNAIDS 2006 estimates that 5.5 million people are living with HIV, and almost 1,000 AIDS deaths occur every day in South Africa. South Africa is currently one of the most severely affected countries in the world. Antiretroviral therapy (ART) is currently the only t

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35

Darin, Areechokchai Wirach Maek-a.-nantawat. "Adverse effects of antiretroviral drugs during pregnancy : A five-year review at Chonburi Hospital, Thailand /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd400/4938552.pdf.

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Thematic Paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2007.<br>LICL has E-Thesis 0024 ; please contact computer services. LIRV has E-Thesis 0024 ; please contact circulation services.

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36

Morén, Núñez Constanza. "Mitochondrial functionalism in HIV-infected children receiving antiretroviral therapy." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83490.

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It is widely known that HIV and ARV drugs trigger mitochondrial impairment in adults. However, their effects in perinatally-infected children have been poorly explored. For this reason, the main hypothesis of the present Thesis was to demonstrate that mitochondrial abnormalities are present in HIV-infected pediatric patients treated with ARV. It is expected to find mitochondrial alterations in asymptomatic perinatally HIV-infected children. This mitochondrial lesion, manifested in a depletion of the mitochondrial genome, would lead to a reduction of the mitochondrial protein synthesis or to

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37

Hansen, Laura Marie. "Mechanical and structural effects of HIV-1 proteins and highly active antiretroviral therapy (HAART) drugs on murine arteries." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45791.

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The overall goals of this project were to develop microstructurally based constitutive models to characterize the mechanical behavior of arteries and to investigate the effects of HIV proteins and antiretroviral drugs on the microstructure and mechanical behavior. To this end we created several constitutive models in aim 1 using a rule of mixtures approach, investigated the role of viral proteins in aim 2 through the use a transgenic mouse model, and studied the effects of the antiretroviral drug AZT administered to mice in aim 3. It is well known that the local mechanical environment which

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38

Thobias, Anna. "Exploration of factors associated with poor adherence among patients receiving antiretroviral therapy at Katutura State Hospital Communicable Disease Clinic in Khomas region, Namibia /." Online access, 2008. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_2455_1273775841.pdf.

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39

Chada, Sravanthi. "A new synthetic approach for preparation of efavirenz." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/15512.

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Efavirenz, a drug that is still inaccessible to millions of people worldwide, is potent non nucleoside reverse transcriptase inhibitor (NNRTI), is one of the preferred agents used in combination therapy for first-line treatment of the human immunodeficiency virus (HIV). NNRTIs attach to and block an HIV enzyme called reverse transcriptase, by blocking reverse transcriptase; NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Efavirenz can't cure HIV/AIDS, but taken in combination with other HIV medicines (called an HIV regimen) every day helps people with HIV live

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40

Mallon, Patrick William Gerard School of Medicine UNSW. "Clinical and molecular aspects of HIV-associated lipodystrophy." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/33048.

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HIV-associated lipodystrophy (HIVLD) syndrome is a condition comprising abnormalities in distribution of body fat and metabolism of lipids and glucose that arises in HIV-infected patients on long-term antiretroviral therapy. This thesis describes clinical research into aspects of the natural history and treatment of HIVLD, as well as molecular research into its pathogenesis centred on subcutaneous adipose tissue. Results demonstrate HIVLD to be a treatment-induced syndrome characterised by initial gains in body fat followed by selective, progressive loss of limb fat. Exposure to thymidineanalo

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41

Li, Wai-sum Rachel, and 李蕙琛. "Effects of abacavir on cardiovascular system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46330288.

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42

Adewumi, Olayinka Anthony. "Treatment outcomes in patients infected with multidrug resistant tuberculosis and in patients with multidrug resistant tuberculosis coinfected with human immunodeficiency virus at Brewelskloof Hospital." Thesis, University of the Western Cape, 2012. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8245_1375971752.

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<p>Many studies have reported low cure rates for multidrug-resistant tuberculosis (MDRTB) patients and MDR-TB patients co-infected with human immunodeficiency virus (HIV). However, little is&nbsp<br>known about the effect of HIV infection and antiretroviral therapy on the treatment outcomes of MDR-TB in South Africa. Therefore, the objectives of the study are: to find out whether HIV infection&nbsp<br>and interactions between ARVs and second line anti-TB drugs have an impact on the following MDR-TB treatment outcomes: cure rate and treatment failure at Brewelskloof Hospital. MDR-TB&nbsp<br>pat

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Müller, Adrienne Carmel. "African traditional medicine-antiretroviral interactions : effects of Sutherlandia frutescens on the pharmacokinetics of Atazanavir." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1013373.

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In response to the urgent call for investigations into antiretroviral (ARV)-African traditional medicine (ATM) interactions, this research was undertaken to ascertain whether chronic administration of the ATM, Sutherlandia frutescens (SF) may alter the bioavailability of the protease inhibitor (PI), atazanavir (ATV), which may impact on the safety or efficacy of the ARV. Prior to investigating a potential interaction between ATV and SF in vitro and in vivo, a high performance liquid chromatography method with ultraviolet detection (HPLC-UV) was developed and validated for the bioanalysis of AT

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44

Sued, Omar Gustavo. "Infección aguda/reciente por el VIH-1. Características clínicas, virológicas e inmunológicas y efectos del tratamiento inmunomediado." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396267.

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Durante la infección por VIH se denomina infección aguda al periodo entre la infección y la seroconversión completa (aproximadamente 30 días). Aunque la mayoría de los pacientes presentan un síndrome clínico denominado “síndrome retroviral agudo” y que se compone de fiebre, cefalea, odinofagia, faringitis, adenopatías y erupción cutánea, menos del 3% de los pacientes se detecta durante este periodo. Su identificación es importante ya que desde el punto de vista representa la fase de mayor transmisión, facilita los estudios de incidencia y la vigilancia de resistencia primaria, el inicio de tra

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45

Jegede, Oyebisi. "Identification and Characterization of Novel Antiretroviral Compounds: from Small Molecule Library Screening to Rationally Designed Compounds." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1185563176.

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Thesis (Ph.D.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed Mar. 11, 2009). Advisor: Miguel Quiñones-Mateu. Keywords: HIV/AIDS, drug discovery, small molecule library screening, characterization of new antiretroviral drugs, highly active antiretroviral therapy. Includes bibliographical references (p. 180-200).

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Cysique, Lucette Adeline Juliette St Vincent's Hospital UNSW. "Aids dementia complex in the era of highly active antiretroviral therapy: a neuropsychological study." Awarded by:University of New South Wales. St. Vincent's Hospital, 2005. http://handle.unsw.edu.au/1959.4/22074.

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The aim of the thesis was to undertake an evaluation of the neuropsychological functioning of non-demented and demented patients with advanced HIV-infection who have been treated with Highly Active Antiretroviral Therapy (HAART) for several years. One hundred and one non-demented HIV-infected individuals and 23 patients with mild or moderate AIDS Dementia Complex (ADC), from the outpatient clinics and Neurology department at St. Vincent's Hospital, Sydney, Australia were randomly selected to participate in a prospective study of the neurological and neuropsychological complications of HIV dise

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47

Masokoane, Kgomotso Quentinne. "Adherence and non-adherence to antiretroviral treatment in HIV people in Port Elizabeth." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1185.

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The introduction of antiretroviral drugs (ARVs) in 1996 transformed the treatment of HIV and AIDS, improving the quality and greatly prolonging the lives of many infected people. HIV (Human Immunodeficiency Virus) is the virus that is believed to cause AIDS. AIDS (Acquired Immune Deficiency Syndrome) is the collection of illnesses or symptoms that ultimately results in death. Antiretroviral (ARVs) drugs or Highly Active Antiretroviral Therapy (HAART) is the treatment that has been applied to combat the HI virus in a bid to slow down the progression of AIDS and ultimately prolong the life of th

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Wagner, Sarah Annette. "Perinatal human immunodeficiency screening in Washington State." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Thesis/Spring2006/s%5Fwagner%5F041406.pdf.

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Fisher, Tarryn-Lee. "The effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the non-oxidative pathways of glucose metabolism." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86469.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: While antiretroviral therapy decreases HIV/AIDS morbidity and mortality, long-term treatment results in insulin resistance and cardiovascular diseases. A possible cause of such adverse effects may be an increase in oxidative stress resulting from protease inhibitor (PI)-induced mitochondrial dysfunction. We therefore hypothesized that PI treatment, specifically Lopinavir/Ritonavir, results in increases in myocardial reactive oxygen species (ROS), leading to downstream outcomes, i.e. elevated apoptosis. Moreover, we proposed that

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Oluoch, Okumu Fredrick. "Synthesis and characterization of bimetallic silver and platinum nanoparticles as electrochemical sensor for nevirapine, an anti-HIV drug." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2319.

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Thesis (DTech (Chemistry))--Cape Peninsula University of Technology, 2016.<br>Bimetallic silver-platinum (Ag-Pt) nanoparticles (NPs) were synthesized via simultaneous reduction of varying mole fractions of metal precursors H2PtCl6.6H2O and AgNO3 by sodium citrate. Kinetics rates of were as follows; Ag NPs (0.079 s-1), Ag-Pt NPs 1:1 (0.082 s-1) and Pt NPs (0.006 s-1). The UV visible spectrum of Ag NPs exhibited a characteristic absorption band while Pt NPs and Ag-Pt bimetallic NPs exhibited no absorption peaks. Successful formation of both monometallic and bimetallic NPs was confirmed via trans

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