Academic literature on the topic 'Antiobesity effects'

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Journal articles on the topic "Antiobesity effects"

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Mark, Allyn L. "Cardiovascular Side Effects of Antiobesity Drugs." Circulation 120, no. 9 (September 2009): 719–21. http://dx.doi.org/10.1161/circulationaha.109.888529.

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Shiffman, Melvin A. "Anesthesia Risks in Patients Who Have Had Antiobesity Medication." American Journal of Cosmetic Surgery 15, no. 1 (March 1998): 3–5. http://dx.doi.org/10.1177/074880689801500102.

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The effects of antiobesity medication can include cardiac valvular disorders and pulmonary hypertension. Fenfluramine, phentermine, and dexfenfluramine are particularly prone to cause these problems. Sudden hypotension with administration of general anesthesia in patients who have taken antiobesity drugs has been reported. The cosmetic surgeon should question patients regarding intake of antiobesity medications and should consider cardiac workup prior to performing surgery.
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Fernández-Galilea, Marta, Pedro L. Prieto-Hontoria, J. Alfredo Martínez, and María J. Moreno-Aliaga. "Antiobesity effects of α-lipoic acid supplementation." Clinical Lipidology 8, no. 3 (June 2013): 371–83. http://dx.doi.org/10.2217/clp.13.19.

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Hwang, Jin Taek, Sanghee Kim, Bo-ra Yoon, Inwook Choi, and Sang Yoon Choi. "Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation." Journal of Chemistry 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/171570.

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The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.
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Cheng, Lizeng, Yang Wei, Lurong Xu, Lanlan Peng, Yuanfeng Wang, and Xinlin Wei. "Gut Microbiota Differentially Mediated by Qingmao Tea and Qingzhuan Tea Alleviated High-Fat-Induced Obesity and Associated Metabolic Disorders: The Impact of Microbial Fermentation." Foods 11, no. 20 (October 14, 2022): 3210. http://dx.doi.org/10.3390/foods11203210.

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Although dark tea is a unique microbial-fermented tea with a high reputation for having an antiobesity effect, little is known about the effect of microbial fermentation on tea leaves’ antiobesity properties. This study compared the antiobesity effects of microbial-fermented Qingzhuan tea (QZT) and unfermented Qingmao tea (QMT), providing insight into their underlying mechanisms associated with gut microbiota. Our results indicated that the supplementation of QMT extract (QMTe) and QZT extract (QZTe) displayed similar antiobesity effects in high-fat diet (HFD)-fed mice, but the hypolipidemic effect of QZTe was significantly stronger than that of QMTe. The microbiomic analysis indicated that QZTe was more effective than QMTe at regulating HFD-caused gut microbiota dysbiosis. Akkermansiaceae and Bifidobacteriaceae, which have negative correlations with obesity, were enhanced notably by QZTe, whereas Faecalibaculum and Erysipelotrichaceae, which are positively correlated with obesity, were decreased dramatically by QMTe and QZTe. A Tax4Fun analysis of QMTe/QZTe-mediated gut microbiota revealed that QMTe supplementation drastically reversed the HFD-induced upregulation of glycolysis and energy metabolism, whereas QZTe supplementation significantly restored the HFD-caused downregulation of pyruvate metabolism. Our findings suggested that microbial fermentation showed a limited effect on tea leaves’ antiobesity, but enhanced their hypolipidemic activity, and QZT could attenuate obesity and associated metabolic disorders by favorably modulating gut microbiota.
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Debellis, Lindsay R., and Mark J. Wrobel. "Pharmacotherapeutic Options for the Treatment of Patients with Obesity." Journal of Pharmacy Technology 28, no. 5 (September 2012): 211–18. http://dx.doi.org/10.1177/875512251202800508.

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Objective: To assess the safety and efficacy of FDA-approved and in-development antiobesity agents. Data Sources: Literature was accessed through MEDLINE (1950-current) and EMBASE using the terms antiobesity agent, diethylpropion, phentermine, orlistat, topiramate, lorcaserin, bupropion, and naltrexone. In addition, reference citations from publications identified were reviewed. Files related to FDA expert panel hearings were retrieved from the FDA website. Study Selection and Data Extraction: Randomized double-blind trials assessing the efficacy and safety of antiobesity agents compared with placebo in the treatment of overweight and obese adults were reviewed. Only English-language or English-translated literature was reviewed. Medications were selected based on FDA approval status. Data Synthesis: Ten double-blind clinical trials were reviewed. There are currently 5 FDA-approved antiobesity agents and 1 agent recently rejected by the FDA. Study results for all agents showed statistically significant weight loss compared with placebo, but with varying adverse effects. The combination of phentermine and topiramate is the most efficacious antiobesity agent approved by the FDA. However, this combination has various neurologic, cardiovascular, and teratogenic safety risks that may limit its use. Based on its safety profile, orlistat is the preferred antiobesity medication, despite the lesser extent to which it induces weight loss versus newer agents. The incidence of unwanted gastrointestinal adverse effects limits its use. Conclusions: Despite a glaring medical need for options to treat obesity, available medications are limited. No current drug option is ideal; each has either safety risks or efficacy concerns. Safe agents that meet FDA efficacy standards are needed to help treat the obesity epidemic.
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Antunes, Kátia Avila, Débora da Silva Baldivia, Paola dos Santos da Rocha, Junior Cesar Casagrande, Eliana Janet Sanjinez Argandoña, Maria do Carmo Vieira, Cláudia Andrea Lima Cardoso, Edson Lucas dos Santos, and Kely de Picoli Souza. "Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/4353604.

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Obesity is a worldwide epidemic that reduces life expectancy; therefore, the search for new alternative and effective treatments is ongoing. The aim of the present investigation was to identify the chemical compounds in the hydroethanolic extract of leaves of Jacaranda decurrens subsp. symmetrifoliolata and to evaluate their toxicity and antiobesity effects. High-performance liquid chromatography was used to identify the chemical constituents, and acute toxicity was evaluated in rats treated with doses of 2 and 5 g·kg−1 body mass. The antiobesity effect was determined in rats with hypercaloric diet-induced obesity. Our results revealed the presence of compounds, such as jacaric, ursolic, and oleic acids, as well as luteolin, quercetin, and kaempferol, in the extract. The acute toxicity tests revealed that rats treated with elevated doses of the extract showed no signs of toxicity. The extract induced reduction in total body mass and the white adipose tissue depots. The obese rats treated with the extract showed an increased fluid intake and feces excretion while their serum total cholesterol and triglyceride levels decreased compared to those in the controls, without any hematological changes. Taken together, the results showed that the constituents of J. decurrens extracts included phenolic compounds and exhibited antiobesity effects with no toxicity.
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Wilson, Carol. "CB1R inverse agonists—antiobesity effects without the neuropsychiatric adverse effects?" Nature Reviews Endocrinology 8, no. 10 (August 14, 2012): 564. http://dx.doi.org/10.1038/nrendo.2012.145.

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Chuah, Li Oon, Wan Yong Ho, Boon Kee Beh, and Swee Keong Yeap. "Updates on Antiobesity Effect ofGarciniaOrigin (−)-HCA." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/751658.

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Garciniais a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)-hydroxycitric acid has been identified as a potential supplement for weight management and as antiobesity agent. Variousin vivostudies have contributed to the understanding of the anti-obesity effects ofGarcinia/hydroxycitric acid via regulation of serotonin level and glucose uptake. Besides, it also helps to enhance fat oxidation while reducingde novolipogenesis. However, results from clinical studies showed both negative and positive antiobesity effects ofGarcinia/hydroxycitric acid. This review was prepared to summarise the update of chemical constituents, significance ofin vivo/clinical anti-obesity effects, and the importance of the current market potential ofGarcinia/hydroxycitric acid.
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Ito, Makoto, Sumiaki Fukuda, Shohei Sakata, Hisayo Morinaga, and Takeshi Ohta. "Pharmacological Effects of JTT-551, a Novel Protein Tyrosine Phosphatase 1B Inhibitor, in Diet-Induced Obesity Mice." Journal of Diabetes Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/680348.

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Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin signaling as well as insulin signaling. JTT-551 is a new PTP1B inhibitor, which is reported to improve glucose metabolism by enhancement of insulin signaling. We have evaluated an antiobesity effect of JTT-551 using diet-induced obesity (DIO) mice. A single administration of JTT-551 was provided to DIO mice with or without leptin, and DIO mice were given food containing JTT-551 for six weeks. A single administration of JTT-551 with leptin treatment enhanced the food inhibition and the signal transducer and activator of transcription 3 (STAT3) phosphorylation in hypothalamus. Moreover, chronic administration of JTT-551 showed an antiobesity effect and an improvement of glucose and lipid metabolism in DIO mice. JTT-551 shows an antiobesity effect possibly by enhancement of leptin signaling and could be useful in the treatment of type 2 diabetes and obesity.
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Dissertations / Theses on the topic "Antiobesity effects"

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Ting, Yu-Hsiang, and 丁于翔. "Combination of Lactobacillus with senna extract for antiobesity effects." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8awf7c.

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Lee, Hsin-Yi, and 李欣怡. "Antiobesity effects and molecular mechanisms of Hsian-tsao extracts in high-fat diet-induced obese rats." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/j55pvp.

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碩士
中山醫學大學
營養學研究所
104
Among the world’s population, the prevalence of obesity has been steadily increasing. Obesity is linked to numerous chronic diseases, such as cardiovascular diseases, type 2 diabetes mellitus, and cancers. Hsian-tsao has been reported to exhibit various beneficial biological activities such as antioxidant, anti-inflammatory, hepatoprotective, and renal protective activities. This study aimed to investigate the anti-obesity effects of 0-100% ethanol extracts of Hsian-tsao (0-100EEHT) in vitro and in vivo models. There are two topics included in this study: (1) Composition analyses and in vitro antiobesity effects of Hsian-tsao and 0-100EEHT. (2) Anti-obesity effect of 40EEHT on high-fat diet (HFD)-induced obese rats was also investigated. (1) The result indicated that the crude fiber and nitrogen free extract were the major proximate composition of Hsian-tsao. Total polyphenolics content, antioxidant activity, and the content of phenolic acids (including protocatechuic acid, chlorogenic acid, p-hydroxybenzoic acid, caffeic acid, vanillic acid, p-coumaric acid) in 40EEHT were higher than that of the other EEHTs. The result indicated that 40EEHT significantly decreases the cell number and intracellular triglyceride content in 3T3-L1 adipocytes. (2) In animal model, the result showed that the weights of body, liver, adipose tissues, as well as hepatic total lipid, triglyceride, and cholesterol in 40EEHT group are significantly decreased as compared to the HFD group. Fecal total lipid, triglyceride, and cholesterol in 40EEHT group were significantly increased as compared to those in the HFD group. Furthermore, the serum levels of triglyceride, ketone body, and MDA, and hepatic MDA in 40EEHT group were significantly decreased as compared to those in the HFD group. Moreover, 40EEHT also significantly increased the levels of hepatic trolox equivalent antioxidant capacity (TEAC) and antioxidant enzymes (including GST and GPx) as compared to the HFD group. In histological analyses of liver and adipose tissue, 40EEHT could reduce the lipid accumulation and adipocyte size as compared to the HFD group. In gene expressions, supplementation with 40EEHT upregulated the gene expressions of SIRT1, AMPK, PGC-1α, PGC-1βCPT-1, ACO, UCP-1, ATGL, HSL, and Adiponectin in the perirenal adipose tissues of HFD rats, whereas it downregulated PPAR-r SREBP-1c, ACC, FAS, aP2, FATP1, CD36, and TNF-α. In gene expressions of livers, 40EEHT significantly increased the gene expressions of SIRT1, AMPK, PGC-1α, PGC-1β,PPAR-α,CPT-1, ACO, ATGL, and HSL in the liver of HFD rats, but downregulated ACC, FAS, SCD-1, FATP1, and LPL. The data indicated that the active compounds of chlorogenic acid, p-hydroxybenzoic acid, and caffeic acid from EEHT significantly decrease the intracellular triglyceride content in 3T3-L1 adipocytes. The results demonstrated that the amelioration of 40EEHT on high-fat diet-induced obesity rats might be related to the active compound (caffeic acid). Therefore, 40% ethanol extracts of Hsian-tsao can be developed as a potential nutraceutical ingredient for preventing obesity.
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Chou, Pei-Hsuan, and 周佩萱. "Antiobesity effects and molecular mechanisms of quercetin-rich supplement on high-fat diet-induced obese rats." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/18213090271577386004.

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碩士
中山醫學大學
營養學研究所
102
Obesity has been recognized as a serious public health problem, associated with several health risks. Quercetin, lycopene, taurine, or litchi flower extract have been reported strong potential anti-obesity activity. However, functional formulas exhibits the strongest synergistic effect compared to single supplement. In the present study, the anti-obesity effects of quercetin-rich supplement, which were combined with quercetin, lycopene, taurine, and litchi flower extract, on high-fat diet (HFD)-induced obese rats were investigated. The data indicated that the weights of body, adipose tissues, and liver, and hepatic total lipid, triglyceride, and cholesterol in quercetin-rich supplement groups were significantly decreased as compared with the HFD group. Fecal total lipid, triglyceride, and cholesterol in quercetin-rich supplement groups were significantly increased as compared with the HFD group. In histological analysis of liver and adipose tissue, quercetin-rich supplement groups were significantly decreased in lipid accumulation and adipocyte size as compared with the HFD group. However, quercetin-rich supplement groups were significantly decreased serum malondialdehyde (MDA), and increased the levels of serum trolox equivalent antioxidant capacity (TEAC) and hepatic antioxidant enzymes as compared with the HFD group. In gene expressions of perirenal adipose tissue, quercetin-rich supplement groups were increased the gene expressions of SIRT1, PPAR-γ, ACO, and CPT-1, as well as decreased the gene expressions of PPAR-α, SREBP-1c, ACC, FAS, HMG-CoA reductase, aP2, FATP1, LPL, PAI-1, and TNF-α as compared with the HFD group. In gene expressions of liver, quercetin-rich supplement groups were also decreased the gene expression of HMG-CoA reductase and increased the gene expressions of AMPK, PPAR-α, ACO, ATGL, and HSL as compared with the HFD group. These results demonstrate that intake of quercetin-rich supplement can be developed as a potential nutraceutical ingredient for preventing obesity.
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Kung, Chao-pin, and 孔昭蘋. "The effects of conjugated linoleic acid on the antiobesity and antioxidant systems in mice fed with high-fat diet." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/333gc4.

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碩士
嘉南藥理科技大學
保健營養系
100
Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of the omega-6 essential fatty acid, linoleic acid. The reduction effect of CLA on the adipose tissue and body weight in mice has been noticed and widely studied. In our previous study, CLA also increased vitamin E status in mice fed with low-fat diet. The aim of this study was to investigate the effects of conjugated linoleic acid on the antiobesity and antioxidants systems in mice fed with high-fat diet. Twenty-four seven-week-old male C57BL/6J mice were assigned to three groups: LF group (containing 5% soybean oil), HF group (containing 3% soybean oil of +17% lard), and CLA group (containing 2% soybean oil +1% CLA +17% lard) were fed with experimental diets for 8 wk. The results showed that α-tocopherol levels of plasma and liver were significantly highest in CLA group. The TBARS concentration of kidney in CLA group was significantly lower than that in LF group (P < 0.05). The TBARS concentration of lung in CLA group was significantly lower than that in HF group (P < 0.05). The levels of urine 8-isoprostane significantly increased in CLA fed mice. CLA group showed a reduction of COX-2 protein expression in liver. In addition, the activities of CAT, SOD, GPx of liver in CLA group showed significantly lower than that in the other two groups (P <0.05). The concentration of plasma adiponectin was significantly lower in CLA group than that in the other two groups. In CLA group, the cholesterol levels in plasma and the triglyceride levels in liver both showed significantly higher than the other groups. In conclusion, CLA could reduced the retroperitoneal fat and epididymal fat mice fed with high-fat diet. CLA increased the α-tocopherol content in plasma and liver and decreased plasma adiponectin levels. The changes of vitamin E status and antioxidant enzyme activity by CLA were also observed in mice when fed with high-fat diet. However, this could be due to the reduction of body fat (where the vitamin E stored) and the oxidative stress increased by high dietary fat.
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Books on the topic "Antiobesity effects"

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Carlton, Janis. Effects of the appetite suppressant drug d-fenfluramine in lean and obese female rats: Central and peripheral antiobesity actions. 1987.

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Book chapters on the topic "Antiobesity effects"

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Kong, Chang-Suk, and Se-Kwon Kim. "Antiobesity and Antidiabetic Effects of Seaweeds." In Handbook of Marine Macroalgae, 371–77. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119977087.ch20.

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Mun, Eun-Gyung, and Youn-Soo Cha. "Korean Traditional Fermented Foods (KTFFs): Antiobesity Effects and Salt Paradox." In ACS Symposium Series, 121–34. Washington, DC: American Chemical Society, 2019. http://dx.doi.org/10.1021/bk-2019-1303.ch009.

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Cheon, Hyae Gyeong. "Antiobesity Effects of Melanin-Concentrating Hormone Receptor 1 (MCH-R1) Antagonists." In Handbook of Experimental Pharmacology, 383–403. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24716-3_18.

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Maeda, Hayato, Masashi Hosokawa, Tokutake Sashima, and Kazuo Miyashita. "Antiobesity Effect of Fucoxanthin from Edible Seaweeds and Its Multibiological Functions." In ACS Symposium Series, 376–88. Washington, DC: American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0993.ch032.

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Woon, Esther C. Y., and Joel D. W. Toh. "Antiobesity Effects of Natural Products from an Epigenetic Perspective." In Studies in Natural Products Chemistry, 161–93. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-444-63294-4.00006-1.

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"- Antiobesity Effects of Conjugated Linoleic Acid: Fact or Fiction?" In Obesity, 582–603. CRC Press, 2012. http://dx.doi.org/10.1201/b12261-35.

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Ju, Kim Hyun, and Han Eung-Soo. "Health Promoting Effects of Kimchi." In Advances in Environmental Engineering and Green Technologies, 73–98. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0591-4.ch004.

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Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic Lactic Acid Bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of other subingredients and formation of fermentation byproducts of LAB promote the fermentation process of LAB to eventually lead to eradication of putrefactive and pathogenic bacteria, and also increase the functionalities of kimchi. Accordingly, kimchi can be considered a vegetable probiotic food that contributes health benefits in a similar manner as yogurt as a dairy probiotic food. Further, the major ingredients of kimchi are cruciferous vegetables; and other healthy functional foods such as garlic, ginger, red pepper powder, and so on are added to kimchi as subingredients. As all of these ingredients undergo fermentation by LAB, kimchi is regarded as a source of LAB; and the fermentative byproducts from the functional ingredients significantly boost its functionality. Because kimchi is both tasty and highly functional, it is typically served with steamed rice at every Korean meal. Health functionality of kimchi, based upon our research and that of other, includes anticancer, antiobesity, anticonstipation, colorectal health promotion, probiotic properties, cholesterol reduction, fibrolytic effect, antioxidative and antiaging properties, brain health promotion, immune promotion, and skin health promotion. In this review we describe the health functionalities of kimchi and the probiotic properties of its LAB.
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Ju, Kim Hyun, and Han Eung-Soo. "Health Promoting Effects of Kimchi." In Food Science and Nutrition, 427–51. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5207-9.ch018.

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Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic Lactic Acid Bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of other subingredients and formation of fermentation byproducts of LAB promote the fermentation process of LAB to eventually lead to eradication of putrefactive and pathogenic bacteria, and also increase the functionalities of kimchi. Accordingly, kimchi can be considered a vegetable probiotic food that contributes health benefits in a similar manner as yogurt as a dairy probiotic food. Further, the major ingredients of kimchi are cruciferous vegetables; and other healthy functional foods such as garlic, ginger, red pepper powder, and so on are added to kimchi as subingredients. As all of these ingredients undergo fermentation by LAB, kimchi is regarded as a source of LAB; and the fermentative byproducts from the functional ingredients significantly boost its functionality. Because kimchi is both tasty and highly functional, it is typically served with steamed rice at every Korean meal. Health functionality of kimchi, based upon our research and that of other, includes anticancer, antiobesity, anticonstipation, colorectal health promotion, probiotic properties, cholesterol reduction, fibrolytic effect, antioxidative and antiaging properties, brain health promotion, immune promotion, and skin health promotion. In this review we describe the health functionalities of kimchi and the probiotic properties of its LAB.
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Hase, Tadashi, and Hiroshige Itakura. "Antiobesity Effect of Long-Term Consumption of Dietary Diacylglycerol in Experimental Animal Models." In Diacylglycerol Oil. AOCS Publishing, 2004. http://dx.doi.org/10.1201/9781439822333.ch9.

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