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Dissertations / Theses on the topic 'Antineoplastika'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Varrica, Maria Giulia Sara. "Sintesi di isossazolidinil-ipa ad arrività antineoplastica." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1546.

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Nel lavoro oggetto della tesi di dottorato viene riportata la sintesi e l attività antineoplastica di una serie di idrocarburi policiclici aromatici (IPA) a core isossazolidinico, isossazolinico ed isossazolico. I composti sono stati preparati per cicloaddizione 1,3-dipolare di nitroni e nitril ossidi con dipolarofili variamente sostituiti. L attività antitumorale è stata valutata su tre linee cellulari (HeLa, HN6, HN13) mediante saggio MTS. I risultati ottenuti mostrano che i derivati isossazolidinici presentano le migliori proprietà; in particolare, il (3R,5S)-3-(1,10-fenantrolin-2-il)-2-(2-

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2

RAIMONDI, Maria Valeria. "SINTESI ED ATTIVITÀ ANTINEOPLASTICA DI NUOVI COMPOSTI ETEROCICLICI." Doctoral thesis, Università degli Studi di Palermo, 2004. http://hdl.handle.net/10447/365532.

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3

Danica, Jović. "Sinteza, karakterizacija i biološka ispitivanja fulerenol/doksorubicin nanokompozita." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=106903&source=NDLTD&language=en.

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U radu je predstavljena sinteza i karakterizacija  novog fulerenol/doksorubicin nanokompozita, sintetisanog sa ciljem dobijanja potencijalne nove nanoformulacije postojećeg antineoplastika doksorubicina, koja bi pokazala veću biolo&scaron;ku aktivnost uz smanjenje neželjenih sporednih efekata koje sam lek izaziva, na prvom mestu kardiotoksičnosti.Nanokompozit fulerenol/doksorbicin je okarakterisan brojnim  metodama prateći dva osnovna eksperimentalna pristupa: molekulsko-spektroskopske metode (XPS, denzitometrija i transportne osobine, NMR, UPLC, Ramanska i UV-spektroskopija, SFM) i

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4

Wan, Jung Wing. "Novel ether lipids as antineoplastic agents." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242627.

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5

Conesa, Milián Laura. "Synthesis of combretastatin analogues with antineoplastic properties." Doctoral thesis, Universitat Jaume I, 2019. http://hdl.handle.net/10803/667097.

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This doctoral thesis belongs to the field of medicinal and pharmacological chemistry. Its aim is the synthesis, characterization and biological evaluation of three families of aminocombretastatin derivatives, compound with antimitotic and antiangiogenic properties. The first group contains a carbamate function in its structure. These derivatives have been studied as antimitotic and vascular disrupting agents. The second family has been designed from sorafenib drug, with the aim of studying its antiangiogenic effects. Regarding the third family, these have been designed as multitarget compo

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6

Molyneux, Gemma. "Studies on the haemotoxicity of antineoplastic agents." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435080.

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7

Chen, Alina. "New polyamine analogues as potential antineoplastic agents." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2680.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The levels of polyamines have been shown to increase in rapidly proliferating cancer cells. Therefore, compounds that inhibit enzymes in polyamine biosynthetic pathway may have therapeutic potential. Compounds capable of providing both in vitro and in vivo inhibition of almost all enzymes in the polyamine biosynthetic pathway are known. An exception is the lack of an agent that inhibits spermidine/spermine N 1 -acetyltransferase (SSAT), the rate-limiting enzyme in the catabolism of polyamines. The desig

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8

Hedmer, Maria. "Monitoring of occupational exposure to antineoplastic drugs." Malmö : Lund University, 2006. http://theses.lub.lu.se/scripta-archive/2006/04/18/med_1298/Maria_H_kappa.pdf.

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9

Bossaer, John B. "Addressing Potential Interactions Between Antineoplastics and Dietary Supplements." Digital Commons @ East Tennessee State University, 2015. https://doi.org/10.2146/ajhp140295.

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10

Rey, Allan W. "Synthetic studies directed towards the antineoplastic macrolide bryostatins." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/5938.

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This thesis describes stereocontrolled and practical routes to the C(1)-C(9), C(17)-C(20), and C(21)-C(27) synthons of bryostatins, which are a closely related family of 20-membered ring lactones embedding 1,3-polyol units. Bryostatins are isolated in minute quantities from the marine Bryozoan Bugula neritina and possess exceptional antineoplastic activity. Membrane-enclosed enantioselective enzymatic hydrolysis was successfully employed for the generation of gram quantities of the versatile building block (3R)-methoxymethoxypentadioic acid, monomethyl ester (51) (Chapter 2). This compound was

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11

Pivetta, Claudia. "Nuovi agenti antineoplastici basati sull'inibizione selettiva della DNA telomerasi." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425160.

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In the search for new anticancer drugs a major goal is to devise more efficient and selective strategies to reduce typical side effects of traditional chemotherapy. Telomerase represents an attractive and selective target. It is expressed in 80-90% of tumor cells whereas its expression in non-malignant cells is limited to stem cells and to hematopoietic system cells. Telomerase inhibition should lead to cancer cells death, with minor side effects on somatic cell lines. Several strategies were developed in order to interfere with telomerase activity and affect cancer cell death pathways. Amon

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12

Fugnoli, L. "MONITORAGGIO DELLA CONTAMINAZIONE DA FARMACI ANTINEOPLASTICI NELLE STRUTTURE OSPEDALIERE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/216408.

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Riassunto La preparazione e la somministrazione dei farmaci antineoplastici espone potenzialmente gli operatori ospedalieri addetti (tecnici di farmacia, infermieri, personale medico) a sostanze chimiche tossiche, e in alcuni casi, cancerogene. Questo problema è avvertito da circa trent’anni in ambito internazionale. In Italia, da dieci anni il ‘Documento di linee guida per la sicurezza e la salute dei lavoratori esposti a chemioterapici antiblastici in ambiente sanitario’ (G.U. n°236 del 7 ottobre 1999) specifica le procedure e i protocolli di prevenzione dell’esposizione e di tutela della

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13

Parker-, Johnson Kitani A. "An evaluation of novel antineoplastic agent on prostate cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2003. http://digitalcommons.auctr.edu/dissertations/3074.

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This study examines the effects of novel antineoplastic agents(isochalcones) on human metastatic prostate cancer cell lines by screening cells for their relative antiproliferative effects, measuring the protein expression levels of specific oncogenes by Western blotting, and evaluating an array of genes ( 5184) to determine possible mechanisms of action of these novel isochalcones. The array data were supported by real-time polymerase chain reaction (PCR) techniques. The antineoplastic agents were screened in human metastatic prostate cancer cell lines (LNCaP, DU145, PC-3, and MDA-PCa-2b) and

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14

Rillo, Ryan A. "Health Issues Related to the Management of Antineoplastic Drugs." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1243889530.

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15

Arshad, Usman [Verfasser]. "Population pharmacokinetic modeling to understand antineoplastic treatment / Usman Arshad." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1239730233/34.

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16

Horgan, Carmel M. T. "Studies on Mitozolomide (CCRG 81010), a new antineoplastic agent." Thesis, Aston University, 1985. http://publications.aston.ac.uk/12474/.

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17

Madiga, Maphuti Carol. "Antioxidative, anti-inflammatory and antineoplastic potential of dicerocaryum species." Thesis, University of Limpopo (Turfloop Campus), 2007. http://hdl.handle.net/10386/926.

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18

Bossaer, John B., and Christan M. Thomas. "Drug Interaction Database Sensitivity With Oral Antineoplastics: An Exploratory Analysis." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2328.

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Purpose: Drug interactions are a concern in oncology with the shift toward oral antineoplastics (OAs). Using electronic databases to screen for drug interactions with OAs is a common practice. There is little literature to guide clinicians on the reliability of these systems with OAs. The primary objective of this study was to explore the sensitivity of commonly available drug interaction databases in detecting drug interactions with OAs. Methods: A list of 20 drug interactions with OAs was developed by two Board-certified oncology pharmacists. The list included multiple types of drug interact

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19

Bossaer, John B., and Christian Thomas. "Drug Interaction Database Sensitivity with Oral Antineoplastics: An Exploratory Analysis." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2339.

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20

Kanyanda, Stonard Sofiel Elisa. "Screening of natural products and Alkylating agents for Antineoplastic Activity." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6433_1363357514.

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<p>Background and objectives: Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors can induce apoptosis. Many anti-cancer drugs work by activating apoptosis in cancer cells. Natural substances have been found to have the ability to induce apoptosis in various tumour cells and these substances have been used as templates for the construction of&nbsp<br>novel lead compounds in anticancer treatment. On the other hand, alkylating

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21

Payne, Jason N. "Development of Dihydrochalcone Functionalized Gold Nanoparticles for Augmented Antineoplastic Activity." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1749.

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Phloridzin, an antidiabetic and antineoplastic agent usually found in fruit trees, is a dihydrochalcone constituent that has a clinical/pharmaceutical significance as a sodiumglucose linked transport 2 (SGLT2) inhibitor. Phloridzin never experienced widespread clinical usage in the pharmaceutical market due to its side effects and poor bioavailability when compared to other antidiabetic therapeutics. The poor bioavailability is primarily attributed to the degradation of the glycosidic bond of the phloridzin, resulting in the formation of phloretin, the aglycone of phloridzin and glucose. While

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22

Rivero-MuÌˆller, Adolfo. "Speciation and reactivity of the antineoplastic copper-based compound : casiopeina II." Thesis, University of Surrey, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301319.

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23

Furbacher, Todd Raymond. "Bioassay-guided isolation of potential antineoplastic natural products from Southwestern plants." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279927.

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This dissertation details the investigation of numerous plants for potential antineoplastic compounds. 144 plants (391 extracts) were prescreened with an assortment of assays. The pre-screens included an Agrobacterium tumefaciens/potato disk gall tumor inhibition assay, a Saccharomyces cerevisiae mutant topoisomerase assay, and an Escherichia coli plasmid scission assay. Bioassay-guided fractionation was conducted on three plants, Phoradendron juniperinum, Psorothamnus thompsoniae , and Acourtia thurberi, using a different assay for each. Phoradendron juniperinum (Viscaceae) was screened with

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24

Trenti, Annalisa. "Analysis of the molecular mechanisms of the antineoplastic effect of ouabain." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422167.

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Ouabain is a cardiac glycoside whose primary action is inhibition of Na/K ATPase activity, a ubiquitous enzyme responsible for translocating Na and K ions across the cell membrane using ATP as the driving force. It has been demonstrated that the Na/K ATPase also functions as a classical receptor, capable of converting cardiac glycodise binding into activation of various protein kinase cascades (Liu and Xie, 2010). Also, recent studies have shown that cardiac glycosides selectively inhibit cell proliferation and/or induce apoptosis in several cancer cell lines (Schoner and Sheiner-Bobis, 2007).

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25

Ganley, Brian. "Investigations into the chemical mechanisms of biological activity by heterocyclic di-N-oxides and 1,2 benzodithiolan-3-one 1-oxides." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999285.

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26

Salvetti, Raul. "Sintesi studio in vitro di nuovi analoghi nucleosidi a potenziale attivita' antivirale o antineoplastica." Montpellier 2, 2004. http://www.theses.fr/2004MON20018.

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La recherche de nouvelles structures nucléosidiques susceptibles d'interférer spécifiquement avec la multiplication des virus reste un défi à relever. Dans la première partie de ce travail, nous nous sommes attachés à la préparation de dérivés nucléosidiques en série 6-aminouracile. Aucun des dérivés synthétisés dans cette première partie n'a présenté d'activité antivirale notable contre un large spectre de virus (VIH, VHB, YFV, BVDV). Par la suite, le deuxième chapitre a été consacré à la synthèse et à l'étude de dérivés en série 5-halogéno-6-aminouridine comme inhibiteurs potentiels de la th

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27

Avebring, Johanna, and Anna-Karin Karlsson. "Att utsätta sig för risker i tjänsten : Sjuksköterskans hantering av antineoplastiska läkemedel – En litteraturstudie." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-72145.

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Introduktion: Under 1970-talet kom den yrkesmässiga exponeringen i samband med behandling med antineoplastiska läkemedel (ANL) i fokus. Exponeringen kan uppstå vid beredning, administrering, hantering av spill, avfall och utsöndring från patient. Vid långvarig exponering eller enstaka högdos exponeringar av dessa läkemedel finns en förhöjd risk för genetiska skador och/eller cancer. Syfte: Syftet med litteraturstudien var att belysa de orsaker som bidrar till att sjuksköterskan exponeras för ANL i tjänsten. Metod: Litteraturstudien genomfördes med utgångspunkt i Polit och Becks struktur för a

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28

MELI, VALERIA. "Theranostic applications of fluorescent liquid crystalline nanoparticles." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266769.

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Lipid liquid crystalline nanoparticles can find application as nanocarriers in several fields of the daily life but, very likely, the pharmaceutical arena is the most relevant. Indeed, several problems encountered in drugs administration (e.g. critical sideeffects from antitumor drugs) require alternative, less invasive, but simultaneously efficient therapeutic routes to be explored. Novel fields of personalized nanomedicine are developing in this direction. One of the most interesting is theranostic, which calls for the design of platforms capable of combining therapeutic and diagnosti

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29

Arab, Sara. "Studies of the antineoplastic activity of verotoxin in vitro and in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27869.pdf.

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30

Dymond, Marcus Karl. "An investigation into the mechanism of action of amphiphilies with antineoplastic properties." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250080.

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31

Shishido, Stephanie Nicole. "Efficacy of gap junction enhancers and antineoplastic drugs in mammary carcinoma models." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16894.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Thu Annelise Nguyen<br>Preclinical animal models of mammary carcinoma formation are vital for the advancement of cancer research, specifically in drug development. Two different types of animal models were utilized to determine the efficacy of combinational treatment of common antineoplastic drugs and the new class of primaquines that act as gap junction enhancers (PQs) at attenuating mammary tumor growth. The classic xenograft mouse model was used to show that PQs could increase the efficacy of cisplatin and paclitaxel.

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32

Xie, Yanqi. "SEMISYNTHETIC AURONES: A FAMILY OF NEWLY DISCOVERED TUBULIN INHIBITORS AS ANTINEOPLASTIC AGENTS." UKnowledge, 2019. https://uknowledge.uky.edu/biochem_etds/44.

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Aurones belong to an uncommon class of plant flavonoids that provide the bright yellow coloration of some ornamental flowers and that possess a range of biological activities. Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate cancer PC-3 xenograft and zebrafish models, selectivity for the colchicine-binding site on tubulin, and absence of appreciab

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33

Ramirez, Daniel A. Kane Robert R. "Synthesis of protected amino thymidines and new thiol derivatives of the vascular targeting agent combretastatin A-4." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5008.

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34

McPherson, John Peter. "DNA topoisomerase IIÃ, role in resistance to antineoplastic agents and induction of apoptosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ35248.pdf.

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35

Hon, Chun-Yip. "Healthcare workers and antineoplastic drugs : evaluating the risks and identifying determinants of exposure." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42505.

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Healthcare workers’ exposure to antineoplastic drugs may occur through handling of the drugs and/or via contact with drug-contaminated surfaces. However, studies have been limited to select departments and/or certain job titles. This may lead to an underestimate of the risk as the drugs circulate within a facility known as the hospital medication system (process flow of drugs). This study aimed to answer the following questions related to antineoplastic drugs and the hospital medication system: 1) is contamination found on surfaces located throughout, 2) are workers throughout occupationally

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36

McCandless, Stewart Grant. "The synthesis of some novel 1,2,3-benzotriazine-platinum complexes with potential antineoplastic activity." Thesis, Heriot-Watt University, 1988. http://hdl.handle.net/10399/999.

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37

Ganley, Brian Christopher. "Investigations into the chemical mechanisms of biological activity by heterocyclic di-N-oxides and 1,2 benzodithiolan-3-one 1-oxides /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999285.

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38

Baglioni, Michele <1977&gt. "Doxorubicina coniugata alla albumina umana lattosaminata: azione antineoplastica sui carcinomi epatocellulari indotti nel ratto dalla dietilnitrosammina." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2147/1/Baglioni_Michele_tesi.pdf.

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The experiments described in the thesis for my PhD were addressed to the study of the anticancer activity of a conjugate of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) on hepatocellular carcinomas (HCCs) induced in rats by diethylnitrosamine. L-HSA is a neoglycoprotein exposing galactosyl residues. The conjugate was prepared to improve the chemo therapeutic index of DOXO in the treatment of the well differentiated (WD) HCCs whose cells mantain the receptor for galactosyl terminating glycoproteins and consequently can actively internalize L-HSA. In my first experiments I found

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39

Baglioni, Michele <1977&gt. "Doxorubicina coniugata alla albumina umana lattosaminata: azione antineoplastica sui carcinomi epatocellulari indotti nel ratto dalla dietilnitrosammina." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2147/.

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The experiments described in the thesis for my PhD were addressed to the study of the anticancer activity of a conjugate of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) on hepatocellular carcinomas (HCCs) induced in rats by diethylnitrosamine. L-HSA is a neoglycoprotein exposing galactosyl residues. The conjugate was prepared to improve the chemo therapeutic index of DOXO in the treatment of the well differentiated (WD) HCCs whose cells mantain the receptor for galactosyl terminating glycoproteins and consequently can actively internalize L-HSA. In my first experiments I found

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40

BUTTA, VALENTINA. "Studio dei potenziali effetti antineoplastici del pioglitazone su cellule staminali tumorali da Glioblastoma Multiforme." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/54504.

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Il glioblastoma multiforme (GBM) è un astrocitoma di IV grado, è il più comune tra i tumori maligni cerebrali. La sopravvivenza media dei pazienti trattati è inferiore a 16 mesi e non è significativamente migliorata in questi ultimi decenni, sottolineando le difficoltà nell’efficace caratterizzazione e trattamento di questo tipo di tumore. L’alta frequenza di recidiva del GBM, il suo elevato potere infiltrante e la resistenza alla radio e chemioterapia rendono urgente lo sviluppo di strategie di trattamento maggiormente efficaci per la cura di questo tumore. La resistenza ai trattamenti conve

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41

Chenault, Darrell Vincent. "Total synthesis of 6-chlorodemethyllavendamycin esters and amides." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115748.

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The synthesis of several 6-Chlorodemethyllavendamycin analogs and their chemistry are described. In this investigation the following compounds were prepared:6-Chlorodemethyllavendamycin methyl ester, 6-Chlorodemethyllavendamycin ethylester, 6-Chlorodemethyllavendamycin butyl ester, 6-Chlorodemethyllavendamycin isoamyl ester, 6-Chlorodemethyllavendamycin octyl ester, and 6-Chlorodemethyllavendamycin amide. Pictet Spengler condensation of 7-amino-6-chloro-2-formylquinoline-5,8-dione with tryptophan methyl ester, tryptophan ethyl ester, tryptophan butyl ester, tryptophan isoamyl ester, tryptophan

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42

Reese, Michael. "Drug design (STAT5 modulators), development (Glyceollin I) and improvement (Esmolol Plus) /." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1265033116.

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Thesis (M.S.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for the Master of Science Degree in Medicinal Chemistry." "A thesis entitled"--at head of title. Bibliography: leaves 45-48.

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43

Sophie, Hamel. "Cardiovascular Effects and Pattern of Use of Antineoplastic Therapies in Female Breast Cancer Patients." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31523.

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Cancer survivors are at greater risk of cardiovascular diseases in comparison to the general population. Cardiovascular disorders are among the most prominent comorbidities in breast cancer patients. In order to gain a better understanding of the prescribing practices and cardiovascular risks associated with oncology drugs, this thesis encompasses a detailed review of the molecular and physiological mechanisms leading to drug‐induced cardiotoxicity and an evaluation of the cardiovascular risks associated with cancer drug therapies. Using a nested case‐control design, we evaluated whether these

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44

Hardy, Elizabeth Mary. "Pharmacokinetic and technical studies on novel administration routes for the antineoplastic antimetabolite 5-fluorouracil." Thesis, University of Exeter, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296231.

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45

Doetsch, Natalie, Kimberly Harder-Ibarola, and Aliyah Sheth. "Exploration of Classic Confounders in Lymphoblastoid Cell Lines used to Study Select Antineoplastic Agents." The University of Arizona, 2010. http://hdl.handle.net/10150/623750.

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Class of 2012 Abstract<br>OBJECTIVES: Therapeutic response to chemotherapeutic agents in vitro can be studied using immortalized lymphoblastoid cell lines (LCLs). While LCLs provide a valuable model to study heritable factors and anticancer drug reponse in large populations, the results may be confounded by properties inherent to the model. This study is used to explore possible confounders in Choy et al.’s publicially available dataset (Accession#: GSE11582). METHODS: This study utilized Affymetrics U133A array gene expression and phenotypic data for 162 unrelated LCLs. SPSS was used for two

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46

Claborn, Jordan, Moses Holleyman, and John B. Bossaer. "Consistency of Drug Information Resources in Identifying Drug-drug interactions with Oral Antineoplastic Agents." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2346.

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Targeted oral antineoplastic agents (OAs) have become a staple and rapidly growing field in the realm of cancer treatment. As with any chemotherapeutic/narrow spectrum agent, clinicians have to be aware of potential drug interactions that could interfere with therapy. Drug information databases are a common resource utilized to check for interactions between agents and patient's home medications. A major concern with OAs is that they are usually taken at home as well as picked up at a pharmacy by the patient themselves. With this kind of therapy adherence and patient side effect reporting beco

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47

Clayborn, Jordan, Moses Holleyman, and John B. Bossaer. "Reliability of Drug Information Databases in Identifying Drug-drug Interactions with Oral Antineoplastic Agents." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2349.

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Masquelier, Michèle. "Leukemia chemotherapy : experimental studies on pharmacological optimisation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-046-X/.

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Eskens, D., and A. Gardner. "Specificity and Sensitivity of Drug Interaction Databases to Detect Meaningful QTc Interactions with Oral Antineoplastics." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7800.

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Lin, Tung Yin. "Synthetic studies towards the stellettins /." View online, 2008. http://repository.eiu.edu/theses/docs/32211131443971.pdf.

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