Relevant bibliographies by topics / Antimicrobial biomaterials for wound healing

Academic literature on the topic 'Antimicrobial biomaterials for wound healing'

Author: Grafiati
Published: 14 March 2023

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Journal articles on the topic "Antimicrobial biomaterials for wound healing"

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Antezana, Pablo Edmundo, Sofia Municoy, Claudio Javier Pérez, and Martin Federico Desimone. "Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil." Antibiotics 10, no. 11 (November 20, 2021): 1420. http://dx.doi.org/10.3390/antibiotics10111420.

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.
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Râpă, M., M. D. Berechet, C. Gaidău, R. R. Constantinescu, and A. Moșuțiu. "ANTIMICROBIAL PROPERTIES OF RABBIT COLLAGEN GLUE-CHITOSAN BIOMATERIAL LOADED WITH CYMBOPOGON FLEXUOSUS ESSENTIAL OIL." TEXTEH Proceedings 2021 (October 22, 2021): 385–90. http://dx.doi.org/10.35530/tt.2021.46.

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One approach to develop innovative antimicrobial wound dressing materials is to use natural polymers loaded with antimicrobial agents. The valorisation of animal proteins as biomaterials with antimicrobial properties is a new concern for development of wound healing. Plant esssential oils (EO) also indicate a potential approach for new wound dressing materials able to replace the synthetic antymicrobial agents. In this paper, plant-polymeric film was prepared by casting film-forming emulsion based on lemongrass (Cymbopogon flexuosus) essential oil/Tween 80 dispersed into rabbit collagen glue hydrolysate– chitosan biomaterial. The effect of biomaterial film composition on Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536 standard bacteria, and Candida albicans ATCC 10231 pathogenic fungus was studied according to European Pharmacopoeia 10/2020 as compared with biomaterial film without essential oil. The in vitro antibacterial tests against three bacterial strains showed that the rabbit collagen glue hydrolysate–chitosan biomaterial inhibited all the three microorganisms. The rabbit collagen hydrolysate glue-chitosan film loaded with lemongrass essential oil exhibits antimicrobial activity towards tested microorganisms but lower as compared with control. The explanation could be due to the short time of investigation, or maybe some active compounds constituents of EO, which favour the cellular proliferation. Preparation of rabbit collagen glue hydrolysate-chitosan biomaterial loaded with lemongrass essential oil is an environmentally friendly solution, which may contribute to the development of wound healing materials as an alternative to topical antimicrobial agents.
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Della Sala, Francesca, Gennaro Longobardo, Antonio Fabozzi, Mario di Gennaro, and Assunta Borzacchiello. "Hyaluronic Acid-Based Wound Dressing with Antimicrobial Properties for Wound Healing Application." Applied Sciences 12, no. 6 (March 17, 2022): 3091. http://dx.doi.org/10.3390/app12063091.

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Wound healing is a naturally occurring process that can be aided by a wound dressing properly designed to assure an efficient healing process. An infection caused by several microorganisms could interfere with this process, delaying or even impairing wound healing. Hyaluronic acid (HA), a main constituent of the extracellular matrix (ECM) of a vertebrate’s connective tissue, represents a promising biomaterial for wound dressing thanks to its intrinsic biocompatibility, hydrophilicity and bacteriostatic properties. In this review, different and recent types of HA-based wound dressings endowed with intrinsic antimicrobial properties or co-adjuvated by antimicrobial natural or synthetic agents are highlighted.
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Kim, Jwa-Young, and Hyun Seok. "Role of 4-Hexylresorcinol in the Field of Tissue Engineering." Applied Sciences 10, no. 10 (May 14, 2020): 3385. http://dx.doi.org/10.3390/app10103385.

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4-hexylresorcinol (4-HR), as a derivative of phenolic lipids, has biological and pharmacological properties that are beneficial when used with a biomaterial. It has antimicrobial and antiseptic activity and can thus prevent contamination and infection of biomaterials. 4-HR suppresses the nuclear factor kappa B (NF-κB) signaling pathway related to osteoclast differentiation. The suppression of NF-κB increases the bone formation marker and contributes to new bone formation. The tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by macrophages and suppressed by 4-HR. Suppression of TNF-α decreases osteoclast activity and promotes wound healing. 4-HR increases the vascular endothelial growth factor and has an anti-thrombotic effect. When incorporated into silk vascular patches, it promotes endothelium wound healing. Recently, 4-HR has exhibited biological properties and has been successfully incorporated into various biomaterials. Consequently, it is a useful pharmacological chemical that can be used with biomaterials in the field of tissue engineering.
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Akhmetova, Alma, Georg-Marten Lanno, Karin Kogermann, Martin Malmsten, Thomas Rades, and Andrea Heinz. "Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing." Pharmaceutics 12, no. 5 (May 18, 2020): 458. http://dx.doi.org/10.3390/pharmaceutics12050458.

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The development of biomaterials for wound healing applications requires providing a number of properties, such as antimicrobial action, facilitation of cell proliferation, biocompatibility and biodegradability. The aim of the present study was to investigate morphological and mechanical properties of zein-based microfibers, ultimately aimed at creating an environment suitable for wound healing. This was achieved through co-axial electrospinning of core–shell microfibers, with zein protein in the core and polyethylene oxide (PEO) in the shell. Small amounts of PEO or stearic acid were additionally incorporated into the fiber core to modify the morphology and mechanical properties of zein fibers. The presence of PEO in the core was found to be essential for the formation of tubular fibers, whereas PEO in the shell enhanced the stability of the microfibers in water and ensured high elasticity of the microfiber mats. Tetracycline hydrochloride was present in an amorphous form within the fibers, and displayed a burst release as a result of pore-formation in the fibers. The developed systems exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli, and showed no cytotoxic effect on fibroblasts. Biocompatibility, antimicrobial activity and favorable morphological and mechanical properties make the developed zein-based microfibers a potential biomaterial for wound healing purposes.
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Rossi, Martina, and Pasquale Marrazzo. "The Potential of Honeybee Products for Biomaterial Applications." Biomimetics 6, no. 1 (January 15, 2021): 6. http://dx.doi.org/10.3390/biomimetics6010006.

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The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.
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Varela, Patrícia, Susanna Sartori, Richard Viebahn, Jochen Salber, and Gianluca Ciardelli. "Macrophage immunomodulation: An indispensable tool to evaluate the performance of wound dressing biomaterials." Journal of Applied Biomaterials & Functional Materials 17, no. 1 (January 2019): 228080001983035. http://dx.doi.org/10.1177/2280800019830355.

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A major burden of the healthcare system resides in providing proper medical treatment for all types of chronic wounds, which are usually treated with dressings to induce a faster regeneration. Hence, to reduce healing time and improve the patient’s quality of life, it is extremely important to select the most appropriate constituent material for a specific wound dressing. A wide range of wound dressings exist but their mechanisms of action are poorly explored, especially concerning the immunomodulatory effects that occur from the interactions between immune cells and the biomaterial. Tissue-resident and monocyte-derived recruited macrophages are key regulators of wound repair. These phagocytic immune cells exert specific functions during the different stages of wound healing. The recognition of the substantial role of macrophages in the outcome of the wound healing process requires specific understanding of the immunomodulatory effects of commercially available or newly developed wound dressings. For a precise intervention, it is necessary to obtain more knowledge on macrophage polarization in different phases of wound healing in the presence of the dressings. The main purpose of this review is to collect clinical cases in which macrophage immunomodulation was taken into consideration as an indicator of the performances of novel or mainstream wound dressing materials, including those provided with antimicrobial properties.
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Liang, Yongping, Baojun Chen, Meng Li, Jiahui He, Zhanhai Yin, and Baolin Guo. "Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing." Biomacromolecules 21, no. 5 (May 11, 2020): 1841–52. http://dx.doi.org/10.1021/acs.biomac.9b01732.

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Yudaev, Pavel, Yaroslav Mezhuev, and Evgeniy Chistyakov. "Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects." Gels 8, no. 6 (May 24, 2022): 329. http://dx.doi.org/10.3390/gels8060329.

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The dressings containing nanoparticles of metals and metal oxides are promising types of materials for wound repair. In such dressings, biocompatible and nontoxic hydrophilic polymers are used as a matrix. In the present review, we take a look at the anti-microbial effect of the nanoparticle-modified wound dressings against various microorganisms and evaluate their healing action. A detailed analysis of 31 sources published in 2021 and 2022 was performed. Furthermore, a trend for development of modern antibacterial wound-healing nanomaterials was shown as exemplified in publications starting from 2018. The review may be helpful for researchers working in the areas of biotechnology, medicine, epidemiology, material science and other fields aimed at the improvement of the quality of life.
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Zhang, Ziyan, Shicheng Zhou, Yanzhe Zhang, Dankai Wu, and Xiaoyu Yang. "The dual delivery of growth factors and antimicrobial peptide by PLGA/GO composite biofilms to promote skin-wound healing." New Journal of Chemistry 44, no. 4 (2020): 1463–76. http://dx.doi.org/10.1039/c9nj05389a.

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Dissertations / Theses on the topic "Antimicrobial biomaterials for wound healing"

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Navarro, Requena Claudia. "Stimulation of wound healing and vascularization with calcium-releasing biomaterials." Doctoral thesis, Universitat Politècnica de Catalunya, 2017. http://hdl.handle.net/10803/664572.

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Chronic skin wounds are a major socioeconomic burden in developed societies, affecting specially elder and diabetic people. It is estimated that 1 to 2% of the population will suffer a chronic wound in their lifetime and, as global population ages and adopts a sedentary lifestyle, the incidence of these wounds will continue its upward trend. Chronic injuries are characterized for presenting a complicated and diverse pathophysiology that make them resistant to current therapies. For this reason, novel therapeutic strategies based on the release of growth factors and the use of tissue engineered constructs are being investigated and show promising results. However, very few biologically based products reach the market, mainly due to regulatory, economic and stability constraints, amplifying the need for easily translational novel treatments. Recently, inorganic biomaterials known as bioceramics have been acknowledged for their wound healing and vascularization capability, mainly due to their ion release. Based on this concept, the present thesis project was dedicated to investigate the potential application of novel bioceramics on wound healing and soft tissue regeneration. More specifically we focused on the role of the calcium ion and its release from newly designed bioceramics to stimulate wound healing and blood vessel formation in both in vitro and in vivo systems. Although it is known that calcium affects all the phases of wound healing, the concentrations and release profile that can improve the healing process has not been described. For this reason, we evaluated the effect of different concentrations of extracellular calcium in vitro on dermal fibroblast, a crucial cell type in the skin and the healing process, and found stimulation of relevant biological responses at specific concentrations. In addition, we compared whether similar effects could be obtained with the ion release of newly designed bioceramic particles containing equivalent calcium concentrations. Interestingly, while stimulating most of the effects, the ion release inhibited some responses triggered by calcium alone that are not desired in the context of chronic wound healing. Then, we investigated the cellular mechanism mediating some of the responses stimulated by calcium, focusing on the implication of the calcium-sensing receptor (CaSR). Several agonists of the receptor stimulated similar effects than calcium, suggesting the relevance of the CaSR on fibroblasts behavior, and opening a window to the design of novel bioceramics that release CaSR-agonists. In order to test the healing capability of the above mentioned bioceramic particles in vivo, they were incorporated in a mat of poly(lactic acid) (PLA) fibers. This novel dressing was applied on a model of chronic wounds in vivo, and compared with a mat of particle-free PLA and to a frequently used commercially available dressing. We found that the PLA-bioceramic mat accelerated wound closure and increased vasculature at the injured site at initial time-points. Thus, improved healing was achieved with the newly designed dressing. Finally, a different composite material was synthesized combining bioceramic particles and human mesenchymal stromal cells (hMSC) in a degradable hydrogel, and its vasculogenic potential was evaluated in soft tissue. This material supported hMSC survival and stimulated the release of the angiogenic factor IGF-1 from these cells in vitro. In addition, when implanted in soft tissue of immunocompromised mice, the composite construct improved hMSC survival and generated a more mature vasculature at the site of implantation. In conclusion, this thesis shows that calcium-releasing bioceramics can successfully contribute to the treatment of chronic wounds and soft tissue regeneration.
Las heridas crónicas tienen un gran impacto socioeconómico sobre los países desarrollados, afectando especialmente a personas en edad avanzada y diabéticos. Se estima que entre el 1 y 2% de la población sufrirá una herida crónica a lo largo de su vida y, con el envejecimiento de la población y el aumento del sedentarismo, la incidencia de estas heridas seguirá una tendencia ascendente. Las heridas crónicas presentan una patofisiología complicada y diversa que las hace resistentes a las terapias actuales. Por esta razón, se están desarrollando nuevos productos mediante ingeniería de tejidos basados en el uso de factores de crecimiento y células. Sin embargo, la translación de estas terapias a la clínica es muy complicada por cuestiones regulatorias, económicas y de estabilidad del producto, por lo que hay una gran necesidad de nuevos tratamientos que puedan llegar más fácilmente al mercado. Recientemente, se ha descubierto que los biomateriales inorgánicos llamados biocerámicos pueden estimular la curación de heridas y la vascularización, principalmente a través del efecto de los iones que liberan. Partiendo de esta idea, este proyecto de tesis se ha centrado en investigar el uso potencial de nuevos biocerámicos en curación de heridas y la regeneración de tejido blando. Más concretamente, nos hemos centrado en el rol del ión calcio y su liberación de nuevos biocerámicos para estimular la curación de heridas y la formación de vasos sanguíneos in vitro e in vivo. A pesar de que el calcio afecta en todas las fases de la curación de una herida, las concentraciones y perfil de liberación que pueden mejorar el proceso de curación no han sido descritos. Por ello, evaluamos el efecto de diferentes concentraciones de calcio extracelular en fibroblastos dermales, un tipo celular esencial en el proceso de curación, y encontramos estimulación de diferentes respuestas biológicas a concentraciones específicas. Además, comparamos si se podían obtener efectos similares mediante el producto iónico liberado de unas nuevas partículas biocerámicas con concentraciones equivalentes de calcio. Curiosamente, el producto iónico inhibió algunos efectos estimulados por el calcio en solución que no son deseables en un contexto de tratamiento de heridas crónicas. Entonces, quisimos indagar en el mecanismo celular a través del cual el calcio estimula a los fibroblastos, centrándonos en la implicación del receptor sensor de calcio (CaSR). Varios agonistas de este receptor estimularon respuestas parecidas al calcio, mostrando la relevancia del CaSR sobre el comportamiento de los fibroblastos, y abriendo una ventana al diseño de nuevos biocerámicos con libración de agonistas del CaSR. Por otro lado, quisimos probar la capacidad curativa de las partículas biocerámicas usadas sobre los fibroblastos incorporándolas en fibras de ácido poliláctico. Este nuevo apósito generado se aplicó sobre un modelo de heridas crónicas in vivo, y su efecto se comparó con un apósito de PLA sin partículas y con un apósito comercial. El apósito de PLA-biocerámico aceleró la curación de las heridas además de estimular la formación de vasos sanguíneos a tiempos tempranos, con lo que se consiguió una mejora en la curación. Finalmente, se sintetizó un biomaterial implantable combinado partículas biocerámicas, células madre mesenquimales adultas (hMSC) y un hidrogel sintético degradable, con el objetivo de evaluar su capacitat vasculogénica en tejidos blandos. In vitro, el material mantuvo la superviencia de las células encapsuladas y se aumentó la liberación del factor angiogénico IGF-1. Además, al implantarse en tejido blando de ratones immunodeprimidos, el material con biocerámico mejoró la supervivencia de las hMSC y estimuló la maduración de la vasculatura en el sitio de implantación
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Berry, Douglass Boone II. "Topical Antimicrobial and Bandaging Effects on Equine Distal Limb Wound Healing." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/31393.

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The objective of this study was to determine if topical antimicrobials silver sulfadiazine and povidone-iodine ointment increase rates of healing of equine distal limb wounds that heal by second intention. Second, to determine the effect of bandaging with these topical antimicrobials. Six healthy adult horses were used to create thirty-six, 2.5 cm2 standardized full-thickness metacarpal/tarsal skin wounds. Each wound was exposed to a single treatment: 1.0 % silver sulfadiazine cream bandaged (SSD-B), 1.0 % silver sulfadiazine slow release matrix bandaged (SDX-B), 1.0% silver sulfadiazine slow release matrix not bandaged (SDX-NB), povidone-iodine ointment bandaged (PI-B), untreated control bandaged (C-B) and untreated control not bandaged (C-NB) until healing. Wound area, granulation tissue area and perimeter were measured with planimetry software from digital images obtained at each observation. Exuberant granulation tissue was excised when present. The days until healing, rate of healing parameter, rates of contraction and epithelialization were compared among groups using pair-wise analysis of least square means. The healing parameters and mean days to healing did not statistically differ between groups. Analysis of percent wound contraction and rate of epithelialization between groups was similar. Mean number of days to healing ranged from 83 (PI-B and C-B) to101 (SSD-B). All bandaged wounds produced exuberant granulation tissue requiring excision compared to none of the unbandaged. The identified rates of epithelialization and wound contraction found insignificant differences between antimicrobial treated versus untreated wounds. Similarly, rates of epithelialization and wound contraction found insignificant differences between bandaged versus unbandaged wounds. Topical povidone-iodine and silver sulfadiazine did not increase rates of healing under bandage. The 1.0% silver sulfadiazine slow release matrix not bandaged (SDX-NB) adhered well to dry wounds. Silver sulfadiazine slow-release matrix provides does not impede wound healing and provides good adherence to dry wounds not amenable to bandaging.
Master of Science
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Asadishekari, Maryam. "Design and Engineering of 3D Collagen-Fibronectin Scaffolds for Wound Healing and Cancer Research." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38378.

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Despite our understanding of the importance of the 3D environment on the behaviour of virtually every cell, most studies are still performed within 2D engineered cell culture devices. In this project, the main goal was to design and engineer tunable three-dimensional (3D) extracellular matrix (ECM)-mimicking scaffolds made of collagen and fibronectin (namely the two major building blocks of the ECM) that recapitulate the ECM structural and mechanical properties essential for wound healing and cancer research. Two different methods were implemented to fabricate 3D scaffolds. First, 3D collagen scaffolds with a ‘porous’ structure (fabricated by a previous student via an ice-templating technique) were used. It was shown that, by increasing collagen concentration to 1.25 wt.%, homogenous scaffolds with interconnected pores (needed for cell invasion through the entire scaffold) were obtained. Fibronectin (Fn) was then incorporated using thermal and mechanical gradients to modify protein content and tune scaffolds microarchitecture. The effect of Fn coating of the collagen underlying structure on cell behaviour such as cell adhesion, invasion and matrix deposition was studied. Results showed that overall more cells adhered to Fn-coated scaffolds with respect to pure collagen scaffolds. Furthermore, our findings indicated that cells were also able to sense the conformation of the Fn coating (as assessed by Fluorescence Resonance Energy Transfer, FRET) since they deposited a more compact ECM on compact Fn coating while a more unfolded and stretched ECM was deposited on unfolded Fn coating. Second, 3D more complex physiologically relevant scaffolds with a ‘fibrillar’ structure were fabricated via a cold/warm casting technique. Pure collagen scaffolds were first generated: in cold-cast scaffolds, clear thin and long collagen fibers were observed while warm-cast scaffolds were denser and comprised shorter collagen fibers. The effect of both collagen concentration and casting temperature on scaffolds’ microstructure was studied. Our results indicate a preponderant effect of temperature. We further engineered dual-protein fibronectin-collagen fibrillar scaffolds by incorporating Fn fibers using thermal gradient. Clear Fn fibers were observed in some conditions. FRET assessment of Fn fibers also showed significant difference of Fn conformation. In this more advanced casting technique, cells were initially embedded into the scaffolds, which provided a more homogeneous cell distribution and a better tissue-mimicking setting. In each case, the effect of resulting ECM properties was tested via cell viability assays. Our data indicate that cells were viable after 72 hours, they could proliferate inside the scaffolds and were able to spread in some conditions. Collectively, our 3D ECM-mimicking scaffolds represent a new tunable platform for biological and biomaterial research with many potential applications in tissue engineering and regenerative medicine. Investigating cell behaviour in 3D ECM-mimicking environment will provide valuable insights to understand cancer progression and approaches to limit the progression and ultimately prevent metastasis.
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Heilborn, Johan. "The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-432-5/.

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Hetrick, Evan M. Schoenfisch Mark H. "Antimicrobial and wound healing properties of nitric oxidereleasing xerogels and silica nanoparticles." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1928.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.
Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry Analytical Chemistry." Discipline: Chemistry; Department/School: Chemistry.
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Cady, Emily A. "Engineering an Aligned, Cell-derived ECM for Use in Dermal Wound Healing." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563525833195615.

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Goswami, Tushar. "Chondroitin Sulfate Hydrogels for Total Wound Care Devices." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578587475393225.

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Tansaz, Samira [Verfasser], and Aldo R. [Gutachter] Boccaccini. "Soy protein based biomaterials for soft tissue engineering and wound healing / Samira Tansaz ; Gutachter: Aldo R. Boccaccini." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1144618703/34.

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Osei-Djarbeng, Samuel Nana. "Bioactivity-guided isolation and characterization of antimicrobial and wound healing constituents of some Ghanaian medicinal plants." Thesis, University of East London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533012.

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Screening of ethnomedicinal plants for antimicrobial activity among plants used in Ghanaian folklore medicine to treat infectious conditions was conducted on Alstonia boonei (Apocynaceae), Balanites aegyptiaca (Balatinaceae), Bidens pilosa (Compositae), Distemonanthus benthamianus (Leguminosae), Funtumia elastica (Apocynaceae), Kigelia africana (Bignonaceae), Mitracarpus villosus (Rubiaceae), Parquetina nigrescens (Asclepiadaceae) and Penianthus zenkeri (Menispermaceae). The selection of the plants was based on ethnomedicinal use and literature search and the aim was to investigate the scientific basis of their use in treating infectious diseases. It was, in addition, aimed at selecting the plant with the most potent activity for detailed bioactivity and phytochemical studies. The methanolic extracts of the plants showed antimicrobial activity with an MIC range of 0.5 - 2.0mg/ml against at least three of the test bacteria (Gram-positives and Gram-negatives) and the yeast-like fungi, Candida albicans, used. F. elastica leaf was selected for further bioactivity studies based on its relatively more potent antimicrobial activity. Bioactivity-guided phytochemical investigation of F. elastica, used to treat infections (including dysentery and gonorrhoea), wound and whooping cough, lead to isolation of eight compounds designated as C2RPA, C2RP1, C2RP2, C2RP3, C2RP4, C2RP5, C2RP6 and C2RP7. Three of them were characterized as (-)epicatechin [C2RP1], taxifolin-3ß-O-glucopyranoside [C2RP2] and the rare A-type proanthocyanidin, epicatechin-(4->8; 2-ºO--'7)-epicatechin (4-+8)-epicatechin (proanthocyanidin trimer) [C2RPA] using spectroscopic methods. This is the first report on isolation and characterization of these compounds from F. elastica. In addition, other compounds obtained as mixtures, and characterized to comprise hydrocarbons including hexadecane, octadecane, eicosane, heneicosane, tetracosane, octacosane, nonacosane and heptacosanew ere also identified. Epicatechin, the proanthocyanidin trimer, C2RP4 and C2RP5, showed antimicrobial activity against the Gram-positive bacteria and C. albicans with MIC range of 31- 500gg/m1; C2RP5 exhibiting the highest antimicrobial activity with an MIC of 31 μg/ml against Stapylococcus aureus. These compounds also exhibited an ability to destroy biofilm formed by MRSA using the standard Calgary MBECTM HTP Assay. Fractions of the crude extract and two isolates containing mainly taxifolin-3ß-Oglucopyranoside and proanthocyanidin trimer each exhibited anti-quorum sensing activity by inhibiting the QS controlled phenotypic purple violacein production by Chromobacterium violaceum. Furthermore, the extracts and the compounds isolated also showed an excellent antioxidant activity with ECso values ranging from 3.88μg (for proanthocyanidin trimer) to 24.59μg (for C2RP7). Also, taxifolin-3Q-Oglucopyranoside stimulated proliferation of fibroblast by 19.5% at a concentration of 4μg/ml. The study on F. elastica leaf has shown that in addition to its ability to arrest the growth of micro-organisms, the plant may have other novel mechanisms of attenuating bacterial pathogenicity by way of interfering with quorum sensing signals and formation of biofilm. Furthermore, the anti-oxidant activity and the ability to stimulate growth of fibroblast, coupled with the antimicrobial activity, may suggest that F. elastica may be useful in wound management. The study therefore shows that plants such as F. elastica may be useful in the management of infectious diseases and wound as purported in folklore medicine.
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Lozeau, Lindsay Dawn. "Design and Study of Collagen-Tethered LL37 for Chronic Wound Healing." Digital WPI, 2018. https://digitalcommons.wpi.edu/etd-dissertations/536.

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As society draws closer to the post-antibiotic era and the pipeline for alternatives dries, there is an urgent need for the development of novel antimicrobial therapies that do not promote bacterial resistance, particularly for immunocompromised chronic wound patients. Antimicrobial peptides (AMPs), including human-derived LL37, show considerable promise as broad spectrum alternatives that also have wound healing properties; however, few have been clinically implemented as novel antimicrobials due to their cytotoxicity stemming from a poor understanding of their mechanisms and low stability in vivo. It has been suggested that tethering, or attaching AMPs onto surfaces, is a viable strategy of delivering bioactive AMPs to surfaces while reducing cytotoxicity and improving stability. Thus, we designed new chimeric versions of LL37 with collagen-binding domains (CBD), derived from collagenase (cCBD-LL37) and fibronectin (fCBD-LL37) for non-covalent tethering onto collagen, a prevalent biopolymer in commercially available wound dressings and scaffolds. Our overall hypothesis was that CBDs would mediate stable tethering of broadly active, non-cytotoxic CBD-LL37 onto collagen-based scaffolds. We first studied the loading, release and bioactivities (e.g. antimicrobial activity and cytotoxicity) of each CBD-LL37 on commercially available 100% collagen type I PURACOL® wound scaffolds. We found that both cCBD-LL37 and fCBD-LL37 bound highly to collagen, were active against relevant wound pathogens, demonstrated stable activity after 14 days of release, and were not cytotoxic to human fibroblasts. The addition of different CBDs onto LL37 also markedly altered their soluble bioactivities. Using similar methods, we then studied the loading, release and bioactivity of each CBD-LL37 on a commercially available FIBRACOL® wound scaffolds, comprised of 90% collagen type I and 10% calcium alginate biopolymers. We found that both cCBD-LL37 and fCBD-LL37 also bound highly to and retained on collagen for 14 days, but were only active against Gram-negative P. aeruginosa. This suggested that the presence other biopolymers in addition to collagen, which is common among commercial wound dressings, could cause significant differences in binding, retention and bioactivities of CBD-LL37. To better understand how CBD modification affected CBD-LL37 structure leading to different bioactivities, we studied the CBD sequence-, peptide structure-, concentration-, time-, and bilayer composition-dependent interactions of soluble CBD-LL37 and compared these findings with the properties of unmodified LL37. Using Molecular Dynamics (MD) simulations, circular dichroism (CD) spectroscopy, quartz crystal microbalance with dissipation (QCM-D), and fluorescent bilayer imaging we determined the structural basis behind CBD alterations in bioactivities. MD and CD, in addition to other intrinsic CBD properties (helicity, amphiphilicity, charge) we hypothesized that cCBD-LL37 utilized similar mechanisms as unmodified LL37 while fCBD-LL37 demonstrated based primarily on surface adsorption. We used QCM-D and Voigt-Kelvin viscoelastic modeling to determine the time- and concentration-dependent interactions of unmodified LL37 with model mammalian lipid bilayers, the mechanisms of which are still controversial in literature despite being widely studied. These results were used to propose a model for the interaction mechanism of LL37 with zwitterionic bilayers that aligned with its bioactive concentrations. LL37 adsorbed at concentrations where it is immunomodulatory until reaching a threshold which corresponded with its antimicrobial concentrations. The threshold was correlated to lipid bilayer saturation, after which LL37 formed transmembrane pores. We observed collapse of the bilayer into a rigid proteolipid film at concentrations higher than the reported cytotoxic threshold of LL37. The mechanistic and structural information for each CBD-LL37 and unmodified LL37 provided a baseline for QCM-D and Voigt-Kelvin viscoelastic modeling to further elucidate the time-, concentration-, lipid composition- and CBD sequence-dependent basis behind the observed bioactivities of cCBD-LL37 and fCBD-LL37. We found that similar to LL37, cCBD-LL37 demonstrated pore formation mechanisms likely due to their similar charges, structural content and amphiphilicity. fCBD-LL37 demonstrated time-dependent, adsorption-based mechanism likely due to its anchoring aromatic residues, low charge, and low amphiphilicity. Knowledge gained from this study allowed mechanistic predictions of two newly designed hypothetical CBD-LL37 peptides. Results from this study contribute to a better understanding of a new class of antimicrobial, non-cytotoxic therapies based on collagen-tethered CBD-LL37, bringing it closer to clinical implementation in chronic wound applications and demonstrate the viability of biopolymer tethering as a platform toward using AMPs to quench the resistance crisis.
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Books on the topic "Antimicrobial biomaterials for wound healing"

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Bassett, Pamela. Emerging markets in tissue engineering: Angiogenesis, soft and hard tissue regeneration, xenotransplant, wound healing, biomaterials and cell theraphy. Edited by DiClemente Susan C. 2nd ed. Southborough, MA: D&MD Reports, 1999.

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Wound Healing Biomaterials. Elsevier, 2016. http://dx.doi.org/10.1016/c2014-0-03386-2.

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Wound Healing Biomaterials. Elsevier, 2016. http://dx.doi.org/10.1016/c2014-0-03387-4.

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Ågren, Magnus. Wound Healing Biomaterials - Volume 2: Functional Biomaterials. Elsevier Science & Technology, 2016.

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Ågren, Magnus. Wound Healing Biomaterials - Volume 2: Functional Biomaterials. Elsevier Science & Technology, 2016.

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Ågren, Magnus. Wound Healing Biomaterials - Volume 1: Therapies and Regeneration. Elsevier Science & Technology, 2016.

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Ågren, Magnus. Wound Healing Biomaterials - Volume 1: Therapies and Regeneration. Elsevier Science & Technology, 2016.

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Guisbiers, Gregory. Antimicrobial Activity of Nanoparticles: Applications in Wound Healing and Infection Treatment. Elsevier, 2022.

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Guisbiers, Grégory. Antimicrobial Activity of Nanoparticles: Applications in Wound Healing and Infection Treatment. Elsevier, 2022.

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Al-Ahmed, Amir, ed. Advanced Applications of Micro and Nano Clay. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644901915.

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Due to their characteristic properties, biodegradable nature and non-toxicity, clay-biopolymer based composites have many applications in such advanced fields as drug release, antimicrobial activities, wound healing, tissue engineering, wastewater treatment, food packaging and flame retardant materials. The book reviews fabrication, properties and applications of a great variety of these materials.
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Book chapters on the topic "Antimicrobial biomaterials for wound healing"

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Silver, Frederick H., and David L. Christiansen. "Wound Healing." In Biomaterials Science and Biocompatibility, 241–77. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-0557-9_9.

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Dong, Yixiao, and Geoffrey C. Gurtner. "Cutaneous Wound Healing." In Biomaterials for Cell Delivery, 217–40. Boca Raton : Taylor & Francis, 2018. | Series: Gene and cell therapy series: CRC Press, 2018. http://dx.doi.org/10.1201/9781315151755-9.

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Sørensen, Ole E. "Antimicrobial Peptides in Cutaneous Wound Healing." In Antimicrobial Peptides, 1–15. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-24199-9_1.

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Abrahamse, Heidi, Sathish Sundar Dhilip Kumar, and Nicolette Nadene Houreld. "The Potential Role of Photobiomodulation and Polysaccharide-Based Biomaterials in Wound Healing Applications." In Wound Healing, 211–23. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119282518.ch16.

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Davenport, Matthew, and Laura E. Dickinson. "Engineered Biomaterials for Chronic Wound Healing." In Chronic Wounds, Wound Dressings and Wound Healing, 51–74. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/15695_2017_92.

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Mathur, Anshu B. "Regenerative Wound Healing via Biomaterials." In Bioengineering Research of Chronic Wounds, 405–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00534-3_18.

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Gosai, Haren, Payal Patel, Hiral Trivedi, and Usha Joshi. "Role of Biodegradable Polymer-Based Biomaterials in Advanced Wound Care." In Wound Healing Research, 599–620. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2677-7_18.

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Akeson, W. H., and A. Giurea. "Wound Healing: Potential Therapeutic Modulation." In Biomechanics and Biomaterials in Orthopedics, 126–36. London: Springer London, 2004. http://dx.doi.org/10.1007/978-1-4471-3774-0_12.

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Yap, Polly Soo Xi, Rabiha Seboussi, Kok Song Lai, and Swee Hua Erin Lim. "The Potential of Essential Oils as Topical Antimicrobial Agents in the Age of Artificial Intelligence." In Wound Healing Research, 679–94. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2677-7_22.

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Suzuki, Shuko, and Yoshito Ikada. "Growth Factors for Promoting Wound Healing." In Biomaterials for Surgical Operation, 145–88. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-570-1_7.

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Conference papers on the topic "Antimicrobial biomaterials for wound healing"

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Ko, Frank, Victor Leung, Ryan Hartwell, Heejae Yang, and Aziz Ghahary. "Nanofibre Based Biomaterials -- Bioactive Nanofibres for Wound Healing Applications." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.279.

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Cohen Maslaton, Shir, and Natan T. Shaked. "Wound healing assay of two competing cell types with dry mass measurement." In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV, edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and Christoph K. Hitzenberger. SPIE, 2019. http://dx.doi.org/10.1117/12.2526841.

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Anisiei, Alexandru, Irina Rosca, and Luminita Marin. "Functionalized Chitosan Nanofibers with Enhanced Antimicrobial Activity for Burn Wound Healing Applications." In The First International Conference on “Green” Polymer Materials 2020. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/cgpm2020-07216.

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Ozbolat, Ibrahim T., and Bahattin Koc. "Hybrid Wound Devices for Spatiotemporally Controlled Release Kinetics." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62254.

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This research presents hybrid full thickness wound devices for improved wound healing process. Firstly, a 3D wound bed surface is extracted using imaging study. Then, a 3D lofting process from our previous work [1] is applied to discretize the device geometry into a number of healing regions based on linear wound margin healing fashion. Next, CAD models are developed and inputted into a multi-nozzle rapid prototyping system for biofabrication purposes. Hybrid devices are finally fabricated with varying concentration of biological modifiers and biomaterials to control the release kinetics spatiotemporally. The proposed methodology is implemented and an illustrative hybrid wound device is presented.
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Muganli, Zulal, Gunnur Onak, Utku Kursat Ercan, and Ozan Karaman. "The Effect of Antimicrobial Peptide Conjugated PGCL Sutures on In Vitro Wound Healing." In 2019 Medical Technologies Congress (TIPTEKNO). IEEE, 2019. http://dx.doi.org/10.1109/tiptekno.2019.8895154.

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Putri, Nandita Melati, Prasetyanugraheni Kreshanti, Narottama Tunjung, Alita Indania, Adi Basuki, and Chaula L. Sukasah. "Efficacy of honey dressing versus hydrogel dressing for wound healing." In THE 5TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 5th International Symposium of Biomedical Engineering (ISBE) 2020. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0047363.

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Aykaç, Ahmet, and İzel Ok. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.046.

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Hydrogels are biocompatible and swollen materials that have been used as a wound dressing for years. Among them, chitosan-based hydrogels have become popular in the wound healing process owing to their low toxic, biocompatible, biodegradable, antibacterial properties. Chitosan (CS) has been used either as a pure form or incorporated with polymers or nanoparticles to increase antimicrobial activity and stability. In this context, zinc oxide nanoparticles (ZnO NPs) have been used to enhance antibacterial activity and mesoporous silica nanoparticles (MSN) have been employed to develop mechanical strength and control of drug release time. In this study, we report the synthesis and fully characterizations of ZnO NPs, MSN and the hydrogel by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR). We have also prepared and characterized chitosan-based hydrogels functionalized by MSNs and ZnO NPs.
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Gabriela Ene, Alexandra, Emilia Visileanu, Stelian Sergiu Maier, Diana Popescu, and Alina Vladu. "Functionalized multilayer structures for burns treatment." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002686.

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Wound healing is a multiphase and multifactorial physiological process. The complexity of this phenomenon makes the healing process very difficult and painful due to several abnormalities. Apart from cellular and biochemical components, a number of external pathways also become active during repair and help the tissue to heal. Wound dressing is one of the main external effectors during the healing process of wounds. Wound is the disruption of the integrity of anatomical tissues caused by exposure to any factor [1-2]. The following characteristics are required for ideal modern wound dressings: bio-adhesiveness to the wound surface, ease of applications, easily sterilised inhibition of bacterial invasion, biodegradability, oxygen permeability, nontoxic, etc [3]. The balance between contraction and wound closure depends on the depth and location of the wound and the presence of complications, such as infection which could impair healing [4]. As a response to this problematic issue, as primary or secondary dressing, complex composites matrix for hemostasis and connective tissue regeneration were developed. The three-layered structure consists of outer layer I which plays the role of carrier, insulator and protector of the underlying layers, being elastic, resistant and submicro-porous (to block the physical access of microorganisms to the lesion), layer II – has the purpose of managing the liquid compositions in the lesion area, macroporous and compressible, with open pores and high tortuosity and layer III - impermeable substrate - non-adherent, biologically inert and microporous. The statistical indicators of the defining variables for each variant of textile structures (intended for layers I and III) are calculated, the histograms, the box plot graphs and the interactive spatial graphs, in the form of band type graphs are drawn. The obtaining of the substrate (II) based on hydrogel included an experimental plan with correlated factors, of the laticeal simplex type A {q, m}, with three factors (q=3) and four discretization intervals on the axes of the major simplex (m=4). The experimental matrix of the plan (dosed mass fractions) was designed, as well as the components of the mixtures. The plan was tested for optimality in D and A criteria. The measured experimental response was the apparent density of the hydrogel. The evaluation of the antimicrobial activity of the textile structures was performed using standardized strains: Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739 and Candida albicans ATCC 10231. The biocompatibility assessment of textile supports for layers I and III was performed by MTT viability test and the LDH cell integrity test. The in vitro study for testing the biocompatibility of the functionalized multilayer matrix showed that they are biocompatible because the phenomenon of cell adhesion was present, regardless of the cell line used. In vivo testing according to ISO 10993-6 used the model of thermal burn injury on white rats (Wistar albino). The treated rats showed a rate of rapid healing and at 7 days of treatment the closure of the wound was observed between 40% - 60%, with areas of tissue regeneration. Inhibition of the invasion of exogenous microorganisms has been noted.
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Harley, Brendan A. C. "Collagen Scaffold-Membrane Composites for Mimicking Orthopedic Interfaces." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-54026.

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Tendons are specialized connective tissues that transmit load between bone and muscle, and whose microstructural and compositional features underlie their function. The biological solution to the problem of connecting relatively compliant tendon to stiffer (∼2 orders of magnitude) bone is a gradient interface zone ∼100μm wide. Over the tendon-bone-junction (TBJ) a linear transition takes place in the ECM inorganic:organic (mineral:collagen) ratio as well as mineral crystallinity from that of tendon to bone. While small TBJ injuries can heal via regeneration, severe defects undergo repair-mediated healing characterized by fibrocartilagenous scar tissue with inferior biomechanical and functional properties. Severe TBJ injuries are common in athletes, the elderly, and following severe craniofacial and extremity trauma. Many tendon injuries (i.e. supraspinatus injuries), particularly those associated with acute trauma, are prone to occur at the TBJ due to high levels of region-specific stress concentrations; rotator cuff tendons injuries, one of the most common TBJ injuries, exhibit re-tears at rates as high as 94%. The scale of such defects and current poor clinical results suggest the need for a biomaterial solution that can mimic the dynamic heterogeneities of the native insertion and tendon body to induce rapid, functional regeneration. Three-dimensional collagen-GAG (CG) scaffolds have been successfully used clinically to regenerate large soft tissue defects (skin, peripheral nerves); they act by mimicking the native extracellular matrix (ECM) of the damaged tissue to prevent wound contraction and scar tissue synthesis. However these scaffolds have not traditionally been used for orthopedics due to an inability to recapitulate two critical features of orthopedic tissues: multiscale structural complexity, biomechanical properties. While the multi-scale properties of tendon itself cannot be currently replicated, nature provides an alternative paradigm: core-shell composites. Plant stems combine a porous core with a dense shell to aid osmotic transport (core) while maintaining sufficient tensile/bending stiffness (shell); many bird beaks use core-shell designs to efficiently enhance compressive strength. Here we describe development of three biomaterial engineering approaches to create the next generation of regeneration templates for tendon insertion injuries: composite, spatially patterned CG biomaterials.
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