Relevant bibliographies by topics / Anticancer drug treatment / Dissertations / Theses
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Dissertations / Theses on the topic 'Anticancer drug treatment'

Author: Grafiati
Published: 14 March 2023

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1

Fumagalli, G. "DRUG-CONJUGATES FOR SELF-ASSEMBLED NANOPARTICLES IN ANTICANCER TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/542496.

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This dissertation is an overview on the functionalization of known anticancer compounds in order to form different drug-conjugates able to self-assemble in water to form nanoparticles. This approach is useful to improve the drug delivery properties and pharmacokinetic profile of anticancer drugs. All the described conjugates, except for the ones illustrated in chapter 5, have the same general structure: the anticancer drug is connected to the self-assembly inducer trough a linker. Chapter 1 regards a general introduction about nanomedicine, the advantages of the use of nanotechnology-based s
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2

Golovko, Olga. "The screening for novel proteasome inhibitors as a treatment of cancer using IncuCyte FLR and fluorometric microculture cytotoxicity assay." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160700.

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The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation. Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment. The study aimed to test vari
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3

Brazzale, Chiara. "Gold nanoparticle surface tuning for multimodal treatment of cancer." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424441.

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In the last decades colloidal decorated gold nanoparticles (GNPs) have been studied as platform for drug and gene delivery, for diagnostic and other biomedical applications. These metal nanoparticles are intriguing because of their unique physico-chemical properties that can be exploited for multimodal and combined treatment of cancer. In the present thesis work gold nanoparticles were decorated with a targeting ligand (Folate-PEG) to combine an active and a passive targeting aiming to enhance the selective accumulation within the tumour site. Deep studies have been done to investigate the eff
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Pardella, Elisa. "Therapy-induced stromal senescence promotes prostate cancer progression and aggressiveness." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128061.

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Although chemotherapy still represents the gold-standard treatment option for cancer cure, it often results in several long-term negative side effects, including cancer relapse and acquired resistance to the therapy. Docetaxel is the preferred anticancer drug for several tumor types, including metastatic castrate-resistant prostate cancer. However, it exhibits only modest efficacy and many patients who received Docetaxel treatment experience tumor progression and chemotherapy insensitivity. Therefore, identifying the molecular mechanisms that associate anticancer therapy with its negative byst
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5

Marwah, Mandeep Kaur. "Development of a novel deformable liposomal formulation for the dermal drug delivery of anticancer agents in the treatment of non-melanoma skin cancers." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37493/.

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The incidence of skin cancer is increasing and conventional treatments such as surgery are not suitable for all patients. This study aimed to develop an elastic liposomal gel to be applied directly to the tumour for the controlled release of anti-cancer agents to the dermal layer. The proposed anti-cancer flavonoids EGCG and naringenin as well as the novel potent cytotoxic agent MTL-004 were loaded into the bilayer of liposomes. Furthermore, aqueous gels HEC and HPMC were investigated as carriers for the liposomes to be applied topically. Liposomes loaded with either Tween 80, Tween 20 or sodi
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6

Shaw, Yeng-Jeng. "Small molecule-based drug design of anticancer agents that target protein kinase B / AKT, Bcl-xL and DNA methyltransferases for the treatment of prostate cancer." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1128693982.

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7

Yaacoub, Katherine. "c-FLIP as a potent anticancer target : Enhancement of cancer cell apoptosis by compounds identified through virtual screening." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B011/document.

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FLIP (FLICE inhibitory protein) est une protéine anti-apoptotique qui a des identités de séquence partagées avec la protéine pro-apoptotique caspase-8. FLIP se trouve en compétence avec caspase-8 pour se fixer sur la protéine adaptatrice FADD, ce qui empêche l’activation de caspase-8 bloquant ainsi l'apoptose. Lors du développement des molécules interférant avec des protéines anti-apoptotiques, la recherche d'inhibiteurs de la protéine FLIP qui est surexprimée dans un très grand nombre de cancers, a échoué. Cela s'explique en partie par le fait que peu d'information structurelle de FLIP est ac
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8

Serafin, Antonio Mendes. "Cell biological responses of prostatic tumour cell lines to irradiation and anticancer drugs." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53321.

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Thesis (PhD)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: The "classic" prostate cell lines, DU145, PC-3 and LNCaP, have served as a valuable cell biological model for research into prostate cancer. However, their relevance may be limited because they derive from metastatic, and not from primary normal and tumour epithelium. The cell lines (1532T, 1535T, 1542T, 1542N and BPH-l) have been derived from primary benign and malignant human tumour prostate epithelium and may be more representative. Using these cell lines I have examined the role of basic cell damage responses (repair
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9

Booker, Victoria. "Investigating the occurrence and fate of anticancer drugs in sewage treatment works and the wider aquatic environment." Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/82556/.

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The occurrence of pharmaceuticals in wastewater and the wider environment is of growing concern. This thesis focuses on anticancer drugs - a group of biologicallypotent and often recalcitrant set of chemicals whose fate and impact on the wider freshwater environment is poorly studied. The aims of this thesis were to prioritise a group of anticancer drugs for environmental monitoring programmes (from the many drugs in use), based on their consumption and fate during wastewater treatment; to undertake a national and regional survey of two commonly used anticancer drugs, cyclophosphamide (CP) and
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10

Kotadia, Nayna. "A Study on the Protein Interaction with Different Platinum Compounds." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/8.

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Since the discovery of anti-tumor activity of cisplatin in 1960, significant progress has been made in treating metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like methionine, histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of react
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11

Sabatino, Maria Antonietta. "Combination treatments in in vitro and in vivo models between molecules reverting epigenetic gene silencing and DNA-interacting anticancer drugs." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502390.

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Epigenetic transcriptional gene silencing plays a fundamental role in cancer development and has been considered as a target for cancer therapy in the last few years, mainly due to its reversibility by small molecules. Among the several methylated genes investigated, glutathione-S-transferase CGST) PI, a protein belonging to cellular detoxification systems, has been shown to be extensively promoter-methylated in prostate cancer. My study therefore describes a new therapeutic approach against prostate cancer, based on the combination of demethylating agents and brostallicin, a DNA minor groove
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12

Majmudar, Pooja M. "Investigating Molecular Targets of Phosphaplatins: A Class of Novel Non-DNA-Binding Platinum Anticancer Agents in the Treatment of Ovarian Cancer." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1300373466.

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13

UYSAL, GÜNES. "Dendritiska nanogeler som platform för läkemedelsleverans." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-251007.

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Utveckling av polymer baserade läkemedelsbärare i nanostorlek har blivit allt viktigare för att effektivisera behandling och diagnosering av olika sjukdomar, speciellt cancer. Flera läkemedel som används i kemoterapi har bristfälliga egenskaper som låg löslighet i vatten, oönskad nedbrytbara till dess inaktiva form, och distribution i stora volymer till oönskade organ p.g.a. dess icke-selektiva förmåga. Nanopartiklar är små partiklar med diameter 1-500 nm som genom passiv/aktiv transport kan passera olika biologiska barriärer och transportera läkemedel i optimala mängder till specifika celler.
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14

Dhellemmes, Alice. "Impact de la voie d'administration des anticancéreux sur la qualité de vie des patients : rôles des processus transactionnels et bénéfices d'une éducation thérapeutique." Thesis, Toulouse 2, 2019. http://www.theses.fr/2019TOU20020.

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La délocalisation de la chimiothérapie de l’hôpital vers le domicile et l’arrivée des anticancéreux oraux transforment radicalement le schéma thérapeutique des patients atteints de cancer. Ce dernier, inédit dans le domaine de l’oncologie, fait reposer l’efficacité du protocole sur la responsabilité entière du patient, de la délivrance du médicament à la gestion des effets secondaires. Cet éloignement de la sphère hospitalière et des soins de support amène les patients à gérer également seuls les conséquences psychologiques de la maladie. La première étude de cette thèse est transversale avec
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15

Maniego, Alison R. "Characterization of branched poly(acrylic acid) via capillary electrophoresis and NMR spectroscopy for anticancer drug targeting and delivery." Thesis, 2018. http://hdl.handle.net/1959.7/uws:46101.

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The non-selective nature of anticancer drugs leads to harmful side-effects. This work investigates the branched polymer, poly(acrylic acid), PAA, and its salt, poly(sodium acrylate), PNaA, for their potential as an anticancer drug carrier for better targeted delivery. The binding between the anticancer drug cisplatin and PNaA was investigated using capillary electrophoresis in the critical conditions (CE-CC). The average degree of branching (DB) was also quantified using NMR spectroscopy. The influence of the synthetic parameters on the DB was also investigated. The precision and accuracy of
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16

Mitra, Raja. "Targeted Delivery of Cytotoxic Metal Complexes into Cancer Cells with and without Macromolecular Vehicles." Thesis, 2013. http://etd.iisc.ernet.in/2005/3392.

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Anticancer active metal complexes such as cisplatin are routinely used for treating various cancers since 1978. However, the side effects of cisplatin overwhelm its therapeutic potential, especially in the latter stages of treatment. The nonspecific cytotoxicity of drugs could be avoided if targeted delivery to cancer cells is achieved using two different methodologies namely, enhanced permeability and retention in solid tumors (EPR) and receptor mediated endocytosis using a homing agent (RME). Ru(II)-arene complexes which are delivered specifically into cancer cells by the transferrin enzyme
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17

Jutooru, Indira Devi. "New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7860.

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Methyl 2-cyano-3,11-dioxo-18b-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic triterpenoid that inhibits growth of Panc1 and Panc28 pancreatic cancer cell lines and activates peroxisome proliferator-activated receptor B (PPARB)-dependent transactivation in these cells. CDODA-Me has also induced p21 and p27 protein expression and downregulated cyclin D1; however, these responses were receptor-independent. CDODA-Me induced apoptosis, which was accompanied by receptor-independent induction of the proapoptotic proteins early growth response-1 (Egr-1), nonsteroidal anti-inflammatory drug-activate
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18

Wu, Wei-De, and 吳韋德. "To investigate the effect of Antrodia cinnamomea extracts on the anticancer activity of drugs treatment in hepatocellular carcinoma cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/rt36e5.

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碩士<br>嘉南藥理大學<br>生物科技系<br>103<br>Hepatocellular carcinoma (HCC) is the third most common malignancy worldwide. More than 75% of HCC cases occur in the Asia-Pacific region. In Taiwan, there are about 3,700 patients a year die from liver cancer. There are many chemical drugs have been used in liver cancer therapy. Antrodia cinnamomea is a medicinal fungus that has been served as a functional food in Taiwan for decades. Previous studies have shown that the secondary metabolites form Antrodia cinnamomea have various activities such as antitumor, protection of liver function, anti-inflammation and a
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19

Das, Sangeeta. "Ancillary Ligand Effects On The Anticancer Activity Of Ruthenium(II) Piano Stool Complexes." Thesis, 2009. http://hdl.handle.net/2005/998.

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The thesis “Ancillary Ligand Effects on the Anticancer Activity of Ruthenium (II) Piano Stool Complexes” is an effort to design better antitumor metallodrugs based on ruthenium(II) complexes with various H-bond donor/acceptor ligands and to understand their mechanism of action. Chapter 1 presents a brief review of metallodrugs and their mechanism of action. Different classes of metallodrugs are discussed. A short discussion on ruthenium based anticancer drugs and their established mechanism of action is also included in this chapter. Chapter 2 deals with the synthesis, characterization and a
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20

Hsiao, Ling-Chi, and 蕭翎綺. "A Novel Derivative of 2, 3, 5, 4‘-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) Combined with Anticancer Drugs for Breast Cancer Treatment and Multidrug Resistance Reversal." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2qyq2s.

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21

Da, Costa Elodie. "Caractérisation des activités épigénétiques et anticancéreuses de la proscillaridine A dans les cancers pédiatriques." Thesis, 2019. http://hdl.handle.net/1866/24599.

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Les glycosides cardiotoniques sont des inhibiteurs des pompes sodium / potassium utilisés pour le traitements des insuffisances cardiaques, qui détiennent également des activités anticancéreuses et épigénétiques récemment caractérisées. Toutefois, dans l’objectif de repositionner ces médicaments comme traitement anticancéreux, les mécanismes sousjacents aux activités anticancéreuses et épigénétiques des glycosides cardiotoniques restent à être déterminés. Dans nos travaux, nous révélons que la proscillaridine A est le glycoside cardiotonique qui détient des activités anticancéreuses et é
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