Relevant bibliographies by topics / Antibiotic synthesis/chemistry

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Antibiotic synthesis/chemistry'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Antibiotic synthesis/chemistry"

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Ley, Steven V., J. Andrew Clase, Darren J. Mansfield, and Helen M. I. Osborn. "Synthesis and chemistry of the ionophore antibiotic tetronasin." Journal of Heterocyclic Chemistry 33, no. 5 (September 1996): 1533–44. http://dx.doi.org/10.1002/jhet.5570330509.

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Hanessian, Stephen, and René Roy. "Chemistry of spectinomycin: its total synthesis, stereocontrolled rearrangement, and analogs." Canadian Journal of Chemistry 63, no. 1 (January 1, 1985): 163–72. http://dx.doi.org/10.1139/v85-026.

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The total stereocontrolled synthesis of the antibiotic spectinomycin is described, based on the regiospecific functionalization and manipulation of appropriate starting materials. The tertiary ketol rearrangement of the antibiotic and its derivatives was studied and the stereochemical identity of spectinoic acid was established by chemical correlation. Dihydrospectinomycin derivatives undergo unusual solvolysis reactions.
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Nawfa, Refdinal, Adi Setyo Purnomo, and Herdayanto Sulistyo Putro. "Synthesis of Antibiotic Penicillin-G Enzymatically by Penicillium chrysogenum." Asian Journal of Chemistry 31, no. 10 (August 30, 2019): 2367–69. http://dx.doi.org/10.14233/ajchem.2019.21766.

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Penicillin-G antibiotic was used as the basic ingredient of making antibiotic type β-lactam such as tetracycline, amoxicillin, ampicillin and other antibiotics. Penicillin-G was splited into 6-amino penicillanic acid as the source of β-lactam. The biosynthetic pathway for the formation of penicillin-G in Penicillium chrysogenum cell through the formation of intermediates was carried out in the form of amino acids such as α-aminoadipate, L-cysteine, L-valine which are formed from glucose (food ingredients).The formation of 6-amino penicillanic acid is an amino acid combination of L-cysteine and L-valine, a step part of the formation of antibiotic penicillin-G in P. chrysogenum cells, thus, it is obvious that there are enzymes involved in its formation. The objective of this study was to examine the use of enzymes present in P. chrysogenum cells to produce penicillin-G and 6-amino penicillanic acid using the intermediate compounds α-aminoadipate, L-cysteine, L-valine and phenylacetic acid assisted by NAFA® coenzymes in P. chrysogenum cells which is more permeable. The research method started from producing biomass of P. chrysogenum cells that demonstrated penicillin-producing antibiotic capability, as the source of the enzyme, followed by addition of permeability treatment of P. chrysogenum cell membrane to get immobile of enzyme by its own cell therefore it can be used more than once. After that the enzyme activity was proven by adding α-aminoadipate, L-cysteine, L-valine, phenylacetic acid and NAFA® coenzyme for the formation of penicillin-G, whereas the addition of L-cystein, L-valine and NAFA® coenzyme were aimed to form 6-amino penicillanic acid. The results showed that P. chrysogenum is able to produce antibiotics with stationary early phase on day 6. The best increased permeability of P. chrysogenum cell membranes was obtained using a 1:4 of toluene:ethanol ratio mixture with the highest antibiotic concentration (130.06 mg/L) after testing for the enzymatic formation of antibacterial penicillin-G.
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Inami, Kaoru, and Tetsuo Shiba. "Total Synthesis of Antibiotic Althiomycin." Bulletin of the Chemical Society of Japan 58, no. 1 (January 1985): 352–60. http://dx.doi.org/10.1246/bcsj.58.352.

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Ozkal, Can B., and Süreyya Meric. "Photocatalytic Bacteria Inactivation by TiO2-Ag based Photocatalysts and the Effect on Antibiotic Resistance Profile." Current Analytical Chemistry 17, no. 1 (December 30, 2020): 98–106. http://dx.doi.org/10.2174/1573411016999200711145845.

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Background: In the last decade, research in the field of contaminants of emerging concern proliferated while special interest was focused on antibiotic-resistant bacteria, antibiotic resistance genes as widespread pollutants. Advanced oxidation processes have gained an essential attraction in the field of antibiotics degradation and bacteria inactivation Methods: Photocatalysts in the form of sol-gel based TiO2-Ag-xerogel and green synthesized nanocomposites TiO2-Ag compared with regard to their bacteria inactivation performances and effect on antibiotic resistance behaviour of target strain. Experiments were carried out at parallel plate reactor configuration under UV-A irradiation with an energy equivalent of solar conditions. PEG 600 and Cydonia oblanga seed extract were used as chemical and bio-chemical reducing-stabilizing agents respectively for the synthesis of TiO2-Ag nano-composite. Results: Photocatalyst type/size based alterations in antibiotic resistance profile of intact and post treatment bacteria cells were examined. Besides the improvement in bacteria inactivation kinetics, photocatalytic disinfection with Ag doped xerogels and TiO2-Ag nanocomposites have triggered alterations on E.coli DSM-498 resistance to tetracycline and aminoglycoside antibiotics. Conclusıon: Cydonia oblanga seed extract is proved to be a promising green substitute for the TiO2- Ag chemical synthesis procedure. Considering the aspects of the economic and environmental impact of nano-composite photocatalyst synthesis, cost reduction is achievable both in the sense of production and disposal. The complexity of water matrix must be considered in a way to determine the wide range applicability of the green synthesis of a nano-composite at the pilot scale.
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Ichim, Daniela Luminita, Letitia Doina Duceac, Constantin Marcu, Alin Constantin Iordache, Irina Mihaela Ciomaga, Alina Costina Luca, Elena Roxana Bogdan Goroftei, Geta Mitrea, Daniela Damir, and Liviu Stafie. "Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms." Revista de Chimie 70, no. 10 (November 15, 2019): 3734–37. http://dx.doi.org/10.37358/rc.19.10.7635.

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Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR.
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LEY, S. V., J. A. CLASE, and D. J. MANSFIELD. "ChemInform Abstract: Synthesis and Chemistry of the Ionophore Antibiotic Tetronasin." ChemInform 27, no. 36 (August 5, 2010): no. http://dx.doi.org/10.1002/chin.199636315.

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LEY, S. V., J. A. CLASE, D. J. MANSFIELD, and H. M. I. OSBORN. "ChemInform Abstract: Synthesis and Chemistry of the Ionophore Antibiotic Tetronasin." ChemInform 28, no. 12 (August 4, 2010): no. http://dx.doi.org/10.1002/chin.199712271.

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Katoh, Tadashi, and Shiro Terashima. "Total Synthesis of Antitumor Antibiotic FR900482." Journal of Synthetic Organic Chemistry, Japan 55, no. 11 (1997): 946–57. http://dx.doi.org/10.5059/yukigoseikyokaishi.55.946.

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Chida, Noritaka, Masami Ohtsuka, Keiichi Nakazawa, and Seiichiro Ogawa. "Total synthesis of antibiotic hygromycin A." Journal of Organic Chemistry 56, no. 9 (April 1991): 2976–83. http://dx.doi.org/10.1021/jo00009a009.

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Dissertations / Theses on the topic "Antibiotic synthesis/chemistry"

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Mason, Ian. "The biomimetic synthesis of polyether antibiotic fragments." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235930.

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The asymmetric synthesis of the C13-C27 moiety 44 of the polyether antibiotic etheromycin is described. The final step in the synthesis was the formation of the tricyclic fragment 44 by a biomimetic triepoxide cyclisation cascade. The cyclisation cascade, 144 to 44, is stereospecific and entirely dependent upon the epoxides stereochemistry. The absolute stereochemistry of each of the three epoxides was independently controlled by the Sharpless asymmetric epoxidation methodology. The carbon skeleton of 44 was constructed from geraniol, (R)-methyl 3-hydroxy-2-methylpropionate 117, and two units of t-butyl acetate. Apart from C26, the chiral centres were all controlled by the Sharpless asymmetric epoxidation. The synthetic strategy was designed to effect the stepwise enantioselective introduction of the three epoxides while building the C13-C27 carbon skeleton, and directing a subsequent cascade reaction by an internal nucleophile. Two trisubstituted epoxides were introduced stepwise with >20:1 stereoselectivity by asymmetric epoxidation of a geraniol derived segment. The fragment was manipulated between epoxidations to allow stepwise introduction of the epoxides, and to ensure terminal differentiation of the groups. Both hydroxyl groups used to control epoxidation were subsequently and separately utilised, after conversion to the iodide, in alkyation reactions with the lithium enolate of t-butyl acetate to extend the carbon chain. No other conditions investigated to selectively react α to epoxides were satisfactory. Of the two t-butyl ester groups introduced, one (C_24) was reduced to the aldehyde and coupled in a Julia reaction with a sulphone derived from 117. The resulting trans olefin was converted into a trans homoallylic alcohol, which was epoxidised by Sharpless methodology with 3 : 1 stereoselectivity. The second of the t-butyl esters (C_13) was used as an internal nucleophile to induce the cascade reaction. The natural ring stereochemistry of 44 was assumed from the high predictability and stereocontrol of the epoxidation reactions and confirmed by ^1H NMR nOe difference experiments. The synthesis of the sulphone 161, in which the three contiguous chiral centres and methyl ketone represents a common polyether terminus, was also demonstrated using a stereocontrolled aldol reaction.
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Hill, M. L. "Synthesis of the antiviral antibiotic virantmycin." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373683.

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Casey, Lorraine A. "The synthesis of potential enzyme inhibitors." Thesis, University of Huddersfield, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290421.

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Kang, T. W. "Novel synthesis of #beta#-lactams via radical pathways." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379970.

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Glassford, Ian Michael. "Addressing Antibiotic Resistance: The Discovery of Novel Ketolide Antibiotics Through Structure Based Design and In Situ Click Chemistry." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/410231.

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Chemistry
Ph.D.
Antibiotic resistance has become and will continue to be a major medical issue of the 21st century. If not addressed, the potential for a post-antibiotic era could become a reality, one that the world has not been familiar with since the early 1900’s. Multidrug-resistant hospital-acquired bacterial infections already account for close to 2 million cases and 23,000 deaths in the United States, along with 20 billion dollars of additional medical spending each year. The CDC released a report in 2013 regarding the seriousness of antibiotic resistance and providing a snapshot of costs and mortality rates of the most serious antibiotic resistant bacteria, which includes 17 drug resistant bacteria, such as carbapenem-resistant Enterobacteriaceae, vancomycin-resistant Enterococcus and Staphylococcus aureus, and multidrug-resistant Acinetobacter and Pseudomonas aeruginosa. The development of antibiotic resistance is part of bacteria’s normal evolutionary process and thus impossible to completely stop. To ensure a future where resistant bacteria do not run rampant throughout society, there is a great need for new antibiotics and accordingly, methods to facilitate their discovery Macrolides are a class of antibiotics that target the bacterial ribosome. Since their discovery in the 1950’s medicinal chemistry has created semi-synthetic analogues of natural product macrolides to address poor pharmacokinetics and resistance. Modern X-Ray crystallography has allowed the chemist access to high resolution images of the bacterial ribosome bound to antibiotics including macrolides which has ushered in an era of structure-based design of novel antibiotics. These crystal structures suggest that the C-4 methyl group of third generation ketolide antibiotic telithromycin can sterically clash with a mutated rRNA residue causing loss of binding and providing a structural basis for resistance. The Andrade lab hypothesized that the replacement of this methyl group with hydrogen would alleviate the steric clash and allow the antibiotic to retain activity. To this end, the Andrade lab set out on a synthetic program to synthesize four desmethyl analogues of telithromycin by total synthesis that would directly test the steric clash hypothesis and also provide structure-activity relationships about these methyl groups which have not been assessed in the past. Following will contain highlights of the total synthesis of (-)-4,8,10-didesmethyl telithromycin, (-)-4,10-didesmethyl telithromycin, and (-)-4,8-desmethyl telithromycin and my journey toward the total synthesis of (-)-4-desmethyl telithromycin Traditional combinatorial chemistry uses chemical synthesis to make all possible molecules from various fragments. These molecules then need to be purified, characterized, and tested against the biological target of interest. While high-throughput assay technologies (i.e., automation) has streamlined this process to some extent, the process remains expensive when considering the costs of labor, reagents, and solvent to synthesize, purify, and characterize all library members. Unlike traditional combinatorial chemistry, in situ click chemistry directly employs the macromolecular target to template and synthesize its own inhibitor. In situ click chemistry makes use of the Huisgen cycloaddition of alkyne and azides to form 1,2,3-triazoles, which normally reacts slowly at room temperature in the absence of a catalyst. If azide and alkyne pairs can come together in a target binding pocket the activation energy of the reaction can be lowered and products detected by LC-MS. Compounds found in this way generally show tighter binding than the individual fragments. Described in the second part of this dissertation is the development of the first in situ click methodology targeting the bacterial ribosome. Using the triazole containing third generation ketolide solithromycin as a template we were able to successfully show that in situ click chemistry was able to predict the tightest binding compounds.
Temple University--Theses
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Ashcroft, Neil David. "Towards a total synthesis of the ansamycin antibiotic herbimycin A." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294580.

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Khatri, Hem Raj. "Synthesis of Complex ortho-Allyliodoarenes via Reductive Iodonio-Claisen Rearrangement and Total Synthesis of Antitumor Antibiotic Derhodinosylurdamycin A." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1431342601.

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Chambers, Christopher Steven. "The synthesis of novel analogues of the antitumour antibiotic pyrrolobenzodiazepines." Thesis, University of Huddersfield, 2009. http://eprints.hud.ac.uk/id/eprint/7068/.

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In this thesis, the novel synthesis of tetra- and triazolo-analogues of the pyrrolobenzodiazepines, pyrrolobenzothiadiazepines, benzodiazepines and benzothiadiazepines are described. These compounds are of great interest as synthetic targets due to their potential medical properties. The key processes are the intramolecular 1,3-dipolar cycloaddition between the azide and the nitrile present in compound (1), the azide and the alkyne present in compound (2) the azide and the alkene present in compound (3), to form the novel final compounds of type (4). The synthesis of these precursors from readily available starting materials is discussed. The intramolecular 1,3-dipolar cycloaddition of the alkene with the azide (3) afforded the triazoline(4, Z = CH2) which upon nitrogen extrusion formed either the methyl imine (5) or an aziridine (6) as shown in the Scheme on the next page. Reactions of other alkenes, more highly substituted than compound (3) are also described. This thesis will also describe a general route to triazolobenzodiazepines and triazolobenzothiadiazepines (7, X = CO, SO2; Z = CH). The reactions of the corresponding nitriles (7, X = CO, SO2; Z = N) will also be described, as with other approaches to the pyrrolobenzodiazepines.
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Gavva, Shravan. "Single Step Synthesis of Antibiotic Kanamycin Embedded Gold Nanoparticles for Efficient Antibacterial Activity." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1282.

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Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Streptomyces kanamyceticus. These special antibiotic GNPs are further characterized using several analytical methods like Transmission Electron Microscopy (TEM), Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared Spectroscopy (FTIR), and Ultra-Voilet/Visible spectroscopy (UV/Vis spectroscopy). The following research is a direct bio-friendly embedment of an antibiotic agent on the surface of the GNPs without any secondary capping agent or surface modification procedures.
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Waghwani, Hitesh Kumar. "One-Step Synthesis of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains." TopSCHOLAR®, 2015. http://digitalcommons.wku.edu/theses/1455.

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On the verge of entering the post-antibiotic era, numerous efforts are in place to regain the losing potential of antibiotics which are proving ineffective against common bacterial infections. Engineered nanomaterials, especially gold nanoparticles (GNPs) capped with antibacterial agents are proving to be an effective and novel strategy against multi-drug resistant (MDR) bacteria. In this study, we report a one-step synthesis of kanamycin-capped GNPs (20 ± 5 nm) utilizing the combined reducing and capping ability of the aminoglycoside antibiotic, kanamycin. Antibacterial assays showed dosedependent broad spectrum activity of Kan-GNPs against Gram-positive (Staphylococcus epidermidis and Enterococcus durans), Gram-negative (Escherichia coli and Enterobacter aerogenes) and Kan-resistant and MDR bacterial strains. A significant reduction in the minimum inhibitory concentration (MIC) of Kan-GNPs was observed as compared to free kanamycin against all the sensitive and resistant bacterial strains tested. Mechanistic studies using TEM and fluorescence microscopy showed that Kan- GNPs exerted their bactericidal action through disrupting the cellular membrane resulting in leakage of cytoplasmic content and death of bacterial cells. Results of this study provide a novel method in the development of antibiotic capped GNPs as potent next-generation antibacterial agents.
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Books on the topic "Antibiotic synthesis/chemistry"

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Maier, Martin. Hetero-Diels-Alder Reaktionen mit inversem Elektronenbedarf zur Synthese von Hexopyranosiden. Konstanz: Hartung-Gorre, 1985.

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Bruggink, Alle. Synthesis of -Lactam Antibiotics: Chemistry, Biocatalysis & Process Integration. Springer, 2012.

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Alle, Bruggink, ed. Synthesis of [beta]-lactam antibiotics: Chemistry, biocatalysis & process integration. Dordrecht: Kluwer Academic Publishers, 2001.

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Recent progress in the chemical synthesis of antibiotics. Berlin: Springer-Verlag, 1990.

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Bruggink, Alle. Synthesis of B-Lactam Antibiotics: Chemistry, Biocatalysis & Process Integration. Springer, 2001.

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Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley-VCH, 2008.

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Piet, Herdewijn, ed. Modified nucleosides: In biochemistry, biotechnology, and medicine. Weinheim: Wiley-VCH, 2008.

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Herdewijn, Piet. Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley & Sons, Incorporated, John, 2008.

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Herdewijn, Piet. Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley & Sons, Limited, John, 2008.

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Qureshi, Shireen. Chemistry of the anthracyclinones: The use of carbohydrates as chiral templates in synthetic and structural studiesof new anthracyclinoes stereochemically related to the naturally occuring anti-tumour antibiotics adriamycin, daunomycin and carminomycin. Bradford, 1985.

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Book chapters on the topic "Antibiotic synthesis/chemistry"

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Ito, Yukishige, and Shino Manabe. "Synthesis of Enediyne Antibiotic Oligosaccharides." In Glycoscience: Chemistry and Chemical Biology I–III, 2441–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56874-9_59.

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Nyfeler, R., and P. Ackermann. "Phenylpyrroles, a New Class of Agricultural Fungicides Related to the Natural Antibiotic Pyrrolnitrin." In Synthesis and Chemistry of Agrochemicals III, 395–404. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch036.

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Zwanenburg, B., G. J. Kemperman, J. Zhu, R. de Gelder, F. J. Dommerholt, G. T. M. Titulaer, R. Keltjens, and A. J. H. Klunder. "Molecular Precision in the Chemistry of Cephalosporin type Antibiotics." In Synthesis of β-Lactam Antibiotics, 56–101. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0850-1_2.

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Paris, J. M., J. C. Barrière, C. Smith, and P. E. Bost. "The Chemistry of Pristinamycins." In Recent Progress in the Chemical Synthesis of Antibiotics, 183–248. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75617-7_6.

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Bhattacharjee, Mrinal K. "Antibiotics That Inhibit Protein Synthesis." In Chemistry of Antibiotics and Related Drugs, 129–51. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40746-3_6.

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Bhattacharjee, Mrinal K. "Antibiotics That Inhibit Cell Wall Synthesis." In Chemistry of Antibiotics and Related Drugs, 49–94. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40746-3_3.

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Bhattacharjee, Mrinal K. "Antimetabolites: Antibiotics That Inhibit Nucleotide Synthesis." In Chemistry of Antibiotics and Related Drugs, 95–108. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40746-3_4.

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Bhattacharjee, Mrinal K. "Antibiotics That Inhibit Nucleic Acid Synthesis." In Chemistry of Antibiotics and Related Drugs, 109–28. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40746-3_5.

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Gołebiowski, Adam, and Janusz Jurczak. "Total Synthesis of Lincomycin and Related Chemistry." In Recent Progress in the Chemical Synthesis of Antibiotics, 365–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75617-7_10.

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Bouzard, Daniel. "Recent Advances in the Chemistry of Quinolones." In Recent Progress in the Chemical Synthesis of Antibiotics, 249–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75617-7_7.

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Conference papers on the topic "Antibiotic synthesis/chemistry"

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Vasko, Christopher A., and Christina G. Giannopapa. "Liquid Droplets in Contact With Cold Non-Equilibrium Atmospheric Pressure Plasmas." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63629.

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Recently, cold, non-equilibrium atmospheric pressure plasmas (CAPs) and their active chemistry have been extensively investigated to the benefit of a wide array of applications such as biomedical and industrial applications mainly in the area of materials processing and chemical synthesis, amongst many others. In general, these plasmas operate at standard conditions (i.e. 1 atm, 300K), are small (∼ cm) and rather simple to operate in comparison to other plasmas. Their complex chemistry gives rise to a wide array of both stable and transient reactive species: such as O3, H2O2, OH and NOx, next to charged species and (V)UV-radiation. This chemistry is the reason for their wide spread application and has already found many industrial applications from waste water treatment, stain free detergents and industrial scale production of oxidants. In recent years, bactericidal effects of CAPs gained increasing attention for applications such as dermatology, disinfection, dentistry and cancer treatment or stimulated blood coagulation. This paper aims to highlight recent research into new biological applications for complex mission scenarios involving humans in remote locations using CAPs for disinfection, bleaching or wound healing. Results using radiofrequency plasma jets for the inactivation of Pseudomonas aeruginosa are summarized, highlighting the importance of liquid plasma interactions. Work with such a CAP paved the way for a promising application in the field of biomedical applications presented here. It involves surface barrier discharges which can be used to treat larger surfaces compared to jets. Their physical construction, using floating or contained electrodes, offer a convenient way of controlling electrical current on a large scale, 3D treatment of both conducting and insulating surfaces with minimal heating. These devices may be tailored to specific skin treatments, allowing fast and effective treatment of larger skin surfaces while following the shape of the skin. This might reduce the need for bactericidal agents and would be a valuable application to assist humans in remote locations. These emerging technologies could be essential both for human health care under extreme conditions, as well as for research itself (sterilisation of tools and large areas, etc.). Especially in the absence of abundant resources (antibiotic agents, disinfectants and the like) alternative approaches to support humans in isolated locations have to be developed. Applications based on a good understanding of plasma chemistry would empower health care under extreme conditions to efficiently use and manage in situ resources. Their low mass, compact size, low power consumption and high reliability could make them essential use under extreme conditions.
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Fu, Dong-Jun. "Industrial Method for preparing 3-​chloromethyl oxacephem antibiotic nucleus." In The 21st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04812.

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Journal articles Dissertations / Theses
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