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1

P, Gilbert, Maillard J. -Y, and Godfree A. F, eds. Antibiotic and biocide resistance in bacteria. Oxford: Blackwell Science, 2002.

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2

Amábile-Cuevas, Carlos F. Origin, evolution and spread of antibiotic resistance genes. Austin: R.G. Landes Co., 1993.

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3

Gravelle, Louise N. The antibiotic resistance of bacteria isolated from dental unit waterlines. Sudbury, Ont: Laurentian University, School of Graduate Studies, 2005.

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4

United States. Congress. Office of Technology Assessment., ed. Impacts of antibiotic-resistant bacteria: Thanks to penicillin-- He will come home! Washington, DC: Office of Technology Assessment, Congress of the U.S., 1995.

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5

F, Amábile-Cuevas Carlos, ed. Antibiotic resistance: From molecular basics to therapeutic options. New York: Chapman & Hall, 1996.

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6

Levy, Stuart B. The antibiotic paradox: How miracle drugs are destroying themiracle. London: Plenum Press, 1992.

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7

The antibiotic paradox: How miracle drugs are destroying the miracle. New York: Plenum Press, 1992.

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8

The antibiotic paradox: How the misuse of antibiotics destroys their curative power. 2nd ed. Cambridge, MA: Perseus Pub., 2002.

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9

R, Fogarty Lisa, Oakland County (Mich.). Health Division., and Geological Survey (U.S.), eds. Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. Reston, Va: U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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10

R, Fogarty Lisa, Oakland County (Mich.). Health Division., and Geological Survey (U.S.), eds. Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. Reston, Va: U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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11

1935-, Tipper Donald J., ed. Antibiotic inhibitorsof bacterial cell wall biosynthesis. Oxford: Pergamon, 1987.

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12

1935-, Tipper Donald J., ed. Antibiotic inhibitors of bacterial cell wall biosynthesis. Oxford [Oxfordshire]: Pergamon Press, 1987.

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13

Edgeworth, Jonathan. Antibiotic resistance in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0289.

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The two objectives of ensuring early appropriate antimicrobial treatment for septic patients on the intensive care unit (ICU), and limiting emergence and spread of antimicrobial resistance are both complicated and potentially conflicting. Increasingly unpredictable resistance, particularly amongst Gram-negative bacteria, through both local selection and transmission, and importation of globally successful resistant clones encourages the use of broad-spectrum empiric antimicrobials for septic patients, including in combination. This may lead to a vicious cycle whereby increasing antibiotic use increases resistance, which in turn leads to higher levels of inappropriate therapy. In response, the multi-disciplinary ICU-team implements infection prevention and control, and antimicrobial stewardship programmes. Antimicrobial stewardship programmes provide interventions and guidance to optimize appropriate therapy,whilelimiting unnecessary use through a variety of measures. The development of rapid molecular testing for bacterial identification and antimicrobial susceptibility prediction could potentially bring useful microbiological information to the bedside at the time of therapeutic decision making.
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14

Soulsby, Lord. Antimicrobial resistance: animal use of antibiotics. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0005.

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The evolution of resistance to microbes is one of the most significant problems in modern medicine, posing serious threats to human and animal health. The early work on the use of antibiotics to bacterial infections gave much hope that infectious diseases were no longer a problem, especially in the human field. However, as their use, indeed over use, progressed, resistance (both mono-resistance and multi-resistance), which was often transferable between different strains and species of bacteria, emerged. In addition, the situation is increasingly complex, as various mechanisms of resistance, including a wide range of β -lactamases, are now complicating the issue. The use of antibiotics in animals, especially those used for growth promotion, has come in for serious criticism, especially those where their use should be reserved for difficult human infections. To lend control, certain antibiotic growth promoters have been banned from use in the EU and the UK.It is now a decade since the UK House of Lords Science and Technology Committee (1998) highlighted concerns about antimicrobial resistance and the dangers to human health of resistant organisms derived from animals fed antibiotics for growth promotion or the treatment of infectious diseases. The concern expressed in the House of Lords report was similar to that in other major reports on the subject, for example from the World Health Organization, the Wellcome Foundation, the Advisory Committee on the Microbiological Safety of Food and the Swann Report (1969) in which it was recommended that antibiotics used in human medicine should not be used as growth promoters in animals. At the press conference to launch the Lord’s Report it was emphasized that unless serious attention was given to dealing with resistance ‘we may find ourselves returning to a pre-antibiotic era’. The evolution of resistance is one of the significant problems in modern medicine, a much changed situation when the early work on antibiotics gave hope that infectious diseases were no longer a problem, especially in the human field. Optimism was so strong that the Surgeon General of the USA, William H Stewart, in 1969 advised the US Congress that ‘it is time to close the book on infectious diseases and to declare that work against the pestilence is over’. This comment was not only mistaken but it was also damaging to human health undertakings and also reduced funding for research on infectious diseases.Despite the widespread support for and dependence on antibiotics, resistance was increasingly reported worldwide and to recognize the global problem a group of medical workers established in 1981, at Tufts University, the Alliance for the Prudent use of Antibiotics (APUA). This now has affiliated chapters on over 60 countries, many in the developing world. APUA claims to be the ‘world’s leading organization conducting antimicrobial resistance research, education, capacity building and advocacy at the global and grass roots levels’.
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15

Hopkins, Susan. The international and national challenges faced in ensuring prudent use of antibiotics. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198758792.003.0001.

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In April 2014, the World Health Organization reinforced that without urgent coordinated action by most stakeholders the world is headed for a post-antibiotic era in which common infections and minor injuries, which have been treatable for decades, could kill once again. With the rise in the number of infections due to antibiotic-resistant bacteria and the lack of development of new antibiotics, antimicrobial resistance is a major clinical and public health issue that society needs to tackle. This chapter focuses on the challenges of drug resistance and antimicrobial development together with how healthcare organizations can address this threat. A number of initiatives are discussed, including how prescribers and the public need to ensure that antimicrobials are used widely to prevent any collateral damage.
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16

Wilson, Mary E. Antibiotics. Oxford University Press, 2019. http://dx.doi.org/10.1093/wentk/9780190663414.001.0001.

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A STIRRING EXAMINATION OF A LOOMING CRISIS Virtually everyone has taken antibiotics. They can be lifesavers -- or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline? Antibiotics: What Everyone Needs to Know® examines the personal and societal implications of our planet's most important -- and arguably most overused -- medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: · How antibiotics are used (and overused) in humans, plants, and livestock · The consequences to date, and the potential crisis ahead, as overuse of existing antibiotics breeds new resistance in bacteria · How the globalized world enables antibiotic resistance more quickly · Collateral damage, individually and societally, of antibiotic use · The difficult decisions ahead related to medical care and the food system Grounded in the latest scientific research and translated for general readers, Antibiotics: What Everyone Needs to Know® offers a clear-eyed overview of where we are, and what the future holds, as antibiotics lose their might.
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17

Kaushik, Sanket, and Nagendra Singh, eds. Current Developments in the Detection and Control of Multi Drug Resistance. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150498791220101.

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The rise in the incidence of infections is caused by multi drug resistant (MDR) bacteria, it is essential to elucidate the basic mechanism of antibiotic resistance to discover effective methods for diagnosis and treatment of infections. The use of pathogen-specific probes offers a faster alternative for pathogen detection and could improve the diagnosis of infection. High resolution melting analysis techniques are useful for the detection of multi drug resistant pathogens. Rational Structural Based Drug Design is a common method to identify a lead compound and take it forward for further developments. This book provides information about recent strategies involved in the diagnosis and treatment of infections caused by MDR bacteria. The volume covers the use of molecular probes for the quantification of pathogenic bacteria, along with other techniques mentioned above. Chapters also cover the use of identification of novel drug targets from the Lipid A biosynthesis and also from quorum sensing mediated biofilm formation in MDR bacteria. Chapters also cover herbal alternatives for the treatment of MDR bacteria like the use of Cassia aungustifolia in treatment of various diseases. The reference is suitable for biomedical students, cellular and molecular biologists.
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18

Amabile-Cuevas, Carlos F. Antibiotic Resistance. Eurekah.Com Inc, 2002.

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19

Wilson, A. P. R., and Preet Panesar. Antimicrobial drugs in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0053.

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The pharmacokinetics of antimicrobials are altered in critically-ill patients, particularly in the presence of renal or hepatic failure. Maintaining a choice or diversity of antibiotics is important due to the emergence of resistance. Antibiotic use should also be kept to the minimum and local protocols need to be established. For community-acquired infection, co-amoxiclav or a parenteral cephalosporin can be used, while for hospital-acquired infection, piperacillin/tazobactam, ciprofloxacin, or ceftazidime are recommended. For suspected vascular catheter infection or methicillin-resistant Staphylococcus aureus (MRSA) infection, teicoplanin or vancomycin should be used, with meropenem or imipenem reserved for second line treatment. Prophylactic antibiotics should not be continued once a surgical patient has returned from the theatre. Patients with febrile neutropenia receive piptazobactam, meropenem, ceftazidime or ciprofloxacin and a glycopeptide. Antifungals, usually caspofungin or liposomal amphotericin, are used if fungal infection is suspected, especially after failed antibacterial treatment. Cephalosporin use has declined as they have been linked with emergence of MRSA and Clostridium difficile. However, this reflects overuse and they still have a place as part of a diverse choice of antibiotics. Vancomycin and teicoplanin use has increased greatly in order to treat MRSA and line infections, but resistance remains unusual. Carbapenem use has increased rapidly with the emergence of extended spectrum beta-lactamase producing Gram-negative bacteria.
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20

Gilbert. Antibiotic and Biocide Resistance in Bacteria. Blackwell Scientific Publications (BSP), 2002.

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21

United States. Congress. Office of Technology Assessment, ed. Impacts of antibiotic-resistants bacteria. Washington, DC: Office of Technology Assessment, Congress of the U.S., 1995.

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22

Antibiotic Resistant Bacteria (Deadly Diseases and Epidemics). Chelsea House Publications, 2006.

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23

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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24

Hughes, D., Diarmaid Hughes, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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25

(Editor), Diarmaid Hughes, and Dan I. Andersson (Editor), eds. Antibiotic Development and Resistance. CRC, 2001.

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26

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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27

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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28

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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29

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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30

Levy, Stuart B. Antibiotic Paradox. Hachette Books, 2002.

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31

Phillips, Anthony. National Strategy and Action Plan for Combating Antibiotic Resistant Bacteria. Nova Science Publishers, Incorporated, 2015.

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32

Sillanpää, Mika, and Pardeep Singh. Degradations of Antibiotics and Antibiotic Resistance Bacteria from Various Sources. Elsevier Science & Technology Books, 2022.

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33

Sillanpää, Mika, and Pardeep Singh. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources. Academic Press, 2022.

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34

Bañuls, Anne-Laure, Thi Van Ahn Nguyen, Quang Huy Nguyen, Thi Ngoc Anh Nguyen, Hoang Huy Tran, and Sylvain Godreuil. Antimicrobial resistance: the 70-year arms race between humans and bacteria. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789833.003.0006.

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Antimicrobial resistance started to become a human health issue in the 1940s, following the discovery of the first antibiotics. The golden age of antibiotics (the 1950s through 1970s) marked the beginning of the arms race between humans and bacteria. Antimicrobial resistance is now among the greatest threats to human health; occurring in every region of the world and with the potential to affect anyone, anywhere. We describe the main mechanisms of antimicrobial resistance, as well as how the bacteria evolve into “superbugs.” We detail the role of human activities on the emergence and spread of highly drug-resistant bacteria. Currently, data to identify the specific causes, and to establish the baseline in low-income countries, are lacking. Because of the continual increase of multidrug resistance, the situation is urgent. The chapter ends with a view to the future, with a discussion of the specific problems of low-income countries and initiatives taken.
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35

Impacts of antibiotic-resistant bacteria: Thanks to penicillin-- He will come home! For sale by the U.S. G.P.O., Supt. of Docs, 1995.

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36

Gertz, Alida. Tularemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0067.

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Tularemia, caused by the gram-negative coccobacillus Francisella tularensis, is an extremely infectious bacterial zoonosis. Symptoms depend on site of exposure; they can be nonspecific and may include fever, lymphadenopathy, ulcer or papule, and nausea/vomiting. Natural transmission occurs via small mammals, such as rabbits, or arthropod bites. IV or IM antibiotics are preferred over oral forms. Supportive care is also critical; some patients may require respiratory support. If used as a biological weapon, aerosolized F. tularensis would be the most likely route of transmission. Clinical symptoms would include those of pneumonic tularemia. In the event of a bioterrorist attack, oral administration antibiotics can be used, as the health care system may not be able to accommodate intravenous or intramuscular treatment. Antibiotic resistance should also be considered if patients deteriorate despite use of recommended antibiotics.
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37

Amyes, Sebastian G. B. Bacteria: A Very Short Introduction. 2nd ed. Oxford University Press, 2022. http://dx.doi.org/10.1093/actrade/9780192895240.001.0001.

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Bacteria: A Very Short Introduction explores the nature of bacteria, which are the most abundant form of life on the planet. The first organisms to evolve, they include forms that can survive the toughest environments, from deep rocks to frozen wastes. No other organisms are as adaptable. We are most familiar with them as agents of disease, but benign bacteria are critical to ecosystems, as well as to human health. Bacteria play a significant role in the environment and in disease. We cannot ignore the growing resistance of bacteria to antibiotics.
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38

Oostdijk, Evelien, and Marc Bonten. Oral, nasopharyngeal, and gut decontamination in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0287.

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Many infections are caused by enteric bacilli, presumably from endogenous origin. Selective decontamination of the digestive tract (SDD) was developed to selectively eliminate the aerobic Gram-negative bacilli from the digestive tract, leaving the anaerobic flora unaffected. As an alternative to SDD, investigators have evaluated the effects of selective oropharyngeal decontamination (SOpD) alone. Most detailed data on the effects of SDD and SOpD in ICU-patients come from two studies performed in Dutch ICUs. The Dutch studies provide strong evidence that SDD and SOpD reduce ICUmortality, ICU-acquired bacteraemia with Gram-negative bacteria, and systemic antibiotic use. Although successful application has been reported from several solitary ICUs across Europe, it is currently unknown to what extent these effects can be achieved in settings with different bacterial ecology. More studies are needed on the use of SDD or SOpD as a measure to control outbreaks with multidrug resistant bacteria.
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39

Levy, Stuart B. Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle. Springer London, Limited, 2013.

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40

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit). Landes Bioscience, 1996.

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41

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit). Springer, 1997.

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42

Peterson, Susan, and Staci Reintjes. Otitis Externa, Otitis Media, and Mastoiditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0011.

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Otitis Externa is an infection of external auditory canal. Infection typically occurs via penetration of the epithelial barrier. Patients typically present with inflammation of the auricle, external auditory canal, or outer tympanic membrane. First-line therapy includes topical acidic agents and antibiotic drops. Oral antibiotics should be considered for recurrent infections, those resistant to topical therapy, severe disease, extension beyond the external auditory canal, diabetics, or immunocompromised patients. Otitis Media is an infection of the middle ear. Patients typically present with otalgia, otorrhea, fever, irritability, anorexia, and hearing loss. Mastoiditis is an infection of the mastoid bone. Patients present with pain, swelling, and erythema over the mastoid bone. Fever, irritability, otalgia, and hearing loss are also often present. Infection can be serious and may lead to sepsis, sigmoid sinus thrombosis, and intracranial abscess if not treated appropriately. More common complications include chronic infection, resistant bacteria, and mild hearing loss.
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43

Amabile-Cuevas, Carlos F. Antibiotic Resistance: From Molecular Basics to Therapeutic Options (Medical Intelligence Unit Series). Landes Bioscience, 1997.

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44

Antibiotic-resistant fecal bacteria, antibiotics, and mercury in surface waters of Oakland County, Michigan, 2005-2006. Reston, Va: U.S. Dept. of the Interior, U.S. Geological Survey, 2007.

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45

DeAugustinas, M., and A. Kiely. Periocular Infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0015.

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Periocular Infections occur when there is inflammation of the conjunctiva. Uncomplicated viral infections can usually be managed with careful hand hygiene and lubrication of the eye with artificial tears. More severe infections are notable for purulent discharge, membrane formation, and scarring, and can lead to corneal change. For suspected bacterial conjunctivitis, empiric therapy begins with broad spectrum antibiotic eye drops or ointment, which are supplemented with oral antibiotics in cases associated with pharyngitis and in children with H. influenzae infection. For gonococcal conjunctivitis, systemic ceftriaxone is recommended for both adults and children (including neonates) due to the increasing prevalence of penicillin-resistant N. gonorrhoeae. If the cornea is not involved and the patient is extremely reliable, next day referral to an ophthalmologist in addition to management with IM ceftriaxone is sufficient. Otherwise, admission for IV therapy is advised. Copious, repeated irrigation is also advised to remove inflammatory mediators and debris that can contribute to corneal melting.
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46

The Evolving Threat Of Antimicrobial Resistance Options For Action. World Health Organization, 2012.

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47

Chastre, Jean. Diagnosis and management of nosocomial pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0117.

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Quantitative culture techniques, performed before the introduction of new antibiotics, enable physicians to identify most patients who need immediate treatment for nosocomial pneumonia, and help select optimal therapy in a safe, well-tolerated manner. These techniques avoid resorting to broad-spectrum coverage of all patients with a clinical suspicion of infection, and may minimize the emergence of resistant micro-organisms in the intensive care unit. However, the full impact of this decision tree on patient outcome remains controversial. Antimicrobial therapy of patients with nosocomial pneumonia is a two-stage process. The first stage involves administering broad-spectrum antibiotics at doses maximizing bacterial killing as soon as possible to avoid inadequate treatment in patients with true bacterial pneumonia. The second stage focuses on trying to achieve this objective without overusing or abusing antibiotics. This will need the combination of a number of different steps, including commitment to focused and narrow treatment once the aetiological agents are known, switching to monotherapy after day 3, and shortening duration of therapy to 7–8 days in most patients, as dictated by the patient’s clinical response and microbiological information.
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48

News, PM Medical Health. 21st Century Complete Medical Guide to Antibiotics and Antibiotic Resistance, Drug-Resistant Bacteria, Antimicrobial Susceptibility, Authoritative CDC, ... for Patients and Physicians (CD-ROM). Progressive Management, 2004.

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49

Rello, Jordi, and Bárbara Borgatta. Pathophysiology of pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0115.

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Airway colonization, ventilator-associated tracheobronchitis (VAT), and hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) are three manifestations having the presence of micro-organisms in airways in common. Newer definitions have to consider worsening of oxygenation, in addition to purulent respiratory secretions, chest-X rays opacities, and biomarkers of inflammation. Bacteria are the main causes of HAP/VAP. During hospitalization there’s a shift of airway’s colonizing flora from core organisms to enteric and non-fermentative ones. Macro- and micro-aspiration is the most important source of pneumonia. Endotracheal tube secretion leakage is an important source, serving biofilm as a reservoir. Exogenous colonization is infrequent, but it may contribute to cross-infection with resistant species. Prevention of VAP can be achieved by implementing multidisciplinary care bundles focusing on oral/hand hygiene and control of sedation. Pneumonia develops when micro-organisms overwhelm host defences, resulting in a multifocal process. Risk and severity of pneumonia is determined by bacterial burden, organism virulence and host defences. Innate and adaptive immune responses are altered, decreasing clearing of pathogens. Some deficits of the complement pathway in intubated patients are associated with increased risk for VAP and higher mortality. Micro-arrays have demonstrated specific different immunological signatures for VAP and VAT. Early antibiotic therapy is associated with a decrease in early HAP/VAP incidence, but selects for MDR organisms. Attributable mortality is lower than 10%, but HAP/VAP prolongs length of stay, and dramatically increase costs and use of health care resources.
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50

Dondorp, Arjen M. Other tropical diseases in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0294.

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A wide range of tropical infectious diseases can cause critical illness. Knowledge of the local epidemiology where the disease is acquired is essential. In addition, local resistance patterns of common bacterial pathogens can be very different in tropical countries, so that antibiotic regimens might need adaptation. The ‘surviving sepsis’ guidelines are not always appropriate for the treatment of tropical sepsis. Both diseases require a more restricted fluid management. Leptospirosis is another important tropical disease that can cause sepsis with liver and renal failure or ARDS with pulmonary haemorrhages. Neglected tropical diseases causing neurological syndromes include trypanosomiasis (Sub-Saharan Africa) and rabies. Several viruses in the tropics can cause encephalitis. Recent epidemics of respiratory viruses causing life-threatening pneumonia have had their origins in tropical countries, including severe acute respiratory syndrome, influenza A subtype H5N1 (‘avian influenza’), and recently Middle East respiratory syndrome coronavirus.
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