Relevant bibliographies by topics / Antibiotic delivery

Academic literature on the topic 'Antibiotic delivery'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Antibiotic delivery"

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Karr, Jeffrey C. "Management in the Wound-care Center Outpatient Setting of a Diabetic Patient with Forefoot Osteomyelitis Using Cerament Bone Void Filler Impregnated with Vancomycin." Journal of the American Podiatric Medical Association 101, no. 3 (May 1, 2011): 259–64. http://dx.doi.org/10.7547/1010259.

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Several nonbiodegradable and biodegradable antibiotic cement delivery systems are available for the delivery of antibiotics for adjunctive therapy in the management of osteomyelitis. A major nonbiodegradable delivery system is polymethylmethacrylate beads. Antibiotics that can be incorporated into this delivery system are limited to the heat-stable antibiotics vancomycin and aminoglycosides, tobramycin being the most popular. Calcium sulfate and hydroxyapatite (Cerament Bone Void Filler) is a unique biocompatible and biodegradable ceramic bone void filler that can successfully deliver heat-stable and heat-unstable antibiotics in musculoskeletal infections. The use of Cerament as antibiotic beads has not been previously reported. An off-label case of diabetic foot osteomyelitis successfully managed with surgical bone resection and vancomycin Cerament antibiotic beads is presented. Subsequent surgery for the bone infection and staged removal of the antibiotic beads was not necessary. (J Am Podiatr Med Assoc 101(3): 259–264, 2011)
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Khazi-Syed, Afeefah, Md Tanvir Hasan, Elizabeth Campbell, Roberto Gonzalez-Rodriguez, and Anton V. Naumov. "Single-Walled Carbon Nanotube-Assisted Antibiotic Delivery and Imaging in S. epidermidis Strains Addressing Antibiotic Resistance." Nanomaterials 9, no. 12 (November 25, 2019): 1685. http://dx.doi.org/10.3390/nano9121685.

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Although conventional antibiotics have evolved as a staple of modern medicine, increasing antibiotic resistance and the lack of antibiotic efficacy against new bacterial threats is becoming a major medical threat. In this work, we employ single-walled carbon nanotubes (SWCNTs) known to deliver and track therapeutics in mammalian cells via intrinsic near-infrared fluorescence as carriers enhancing antibacterial delivery of doxycycline and methicillin. SWCNTs dispersed in water by antibiotics without the use of toxic bile salt surfactants facilitate efficacy enhancement for both antibiotics against Staphylococcus epidermidis strain showing minimal sensitivity to methicillin. Doxycycline to which the strain did not show resistance in complex with SWCNTs provides only minor increase in efficacy, whereas the SWCNTs/methicillin complex yields up to 40-fold efficacy enhancement over antibiotics alone, suggesting that SWCNT-assisted delivery may circumvent antibiotic resistance in that bacterial strain. At the same time SWCNT/antibiotic formulations appear to be less toxic to mammalian cells than antibiotics alone suggesting that nanomaterial platforms may not restrict potential biomedical applications. The improvement in antibacterial performance with SWCNT delivery is tested via 3 independent assays—colony count, MIC (Minimal Inhibitory Concentration) turbidity and disk diffusion, with the statistical significance of the latter verified by ANOVA and Dunnett’s method. The potential mechanism of action is attributed to SWCNT interactions with bacterial cell wall and adherence to the membrane, as substantial association of SWCNT with bacteria is observed—the near-infrared fluorescence microscopy of treated bacteria shows localization of SWCNT fluorescence in bacterial clusters, scanning electron microscopy verifies SWCNT association with bacterial surface, whereas transmission electron microscopy shows individual SWCNT penetration into bacterial cell wall. This work characterizes SWCNTs as novel advantageous antibiotic delivery/imaging agents having the potential to address antibiotic resistance.
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Yalamanchi, Pratyusha, Ashley Parent, and Marc Thorne. "Optimization of Delivery of Pediatric Otolaryngology Surgical Antibiotic Prophylaxis." Otolaryngology–Head and Neck Surgery 163, no. 2 (June 23, 2020): 275–79. http://dx.doi.org/10.1177/0194599820933191.

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Objectives There is limited evidence regarding use of routine perioperative antibiotics for pediatric otolaryngologic procedures. The objectives of this quality improvement study were (1) to characterize the otolaryngology case mix for which antibiotics were delivered and (2) determine the percentage of surgical encounters with appropriate timing of antibiotic administration. Methods Pediatric otolaryngology procedures meeting criteria from 2015 to 2019 were evaluated as a component of an institution-wide pediatric surgical antibiotic prophylaxis study using A3 problem solving to identify and roll out interventions for appropriate antibiotic administration. Descriptive statistical analysis of the interrupted time-series data was used to describe the otolaryngology case mix for which antibiotics were delivered. The primary outcome measure was percentage of surgical encounters with appropriate timing of antibiotic administration in minutes relative to incision. Results In total, 1520 pediatric otolaryngology procedures with perioperative antibiotic delivery were performed from July 2015 to September 2019. While surgical site infection number (n = 2/year) was stable, administration of timely prophylactic antibiotics significantly improved: 27.5% of cases per month at baseline and 86.9% at the conclusion of the rollout of the sequential interventions ( P < .001). Discussion Given the exceedingly low infection rate of clean otolaryngology surgery, there is limited evidence in favor of perioperative antibiotics for the majority of procedures. Prophylactic antibiotics were most commonly used in otologic surgery involving cochlear implantation or in the setting of draining ears or cholesteatoma and in clean-contaminated head and neck surgery cases. Implications for Practice Iterative continuous performance improvement can optimize evidence-based delivery of preoperative prophylactic antibiotics. Additional interventions to ensure antimicrobial stewardship in pediatric otolaryngology are indicated.
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Shukla, Shashank, and Anita Shukla. "Tunable antibiotic delivery from gellan hydrogels." Journal of Materials Chemistry B 6, no. 40 (2018): 6444–58. http://dx.doi.org/10.1039/c8tb00980e.

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Skwarczynski, Mariusz, Sahra Bashiri, Ye Yuan, Zyta M. Ziora, Osama Nabil, Keita Masuda, Mattaka Khongkow, et al. "Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents." Antibiotics 11, no. 3 (March 18, 2022): 412. http://dx.doi.org/10.3390/antibiotics11030412.

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The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
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R, Priyanka, and Sayani Bhattacharyya. "A REVIEW ON PROMISING ANTIBIOTIC THERAPY BY NOVEL DELIVERY SYSTEMS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (May 1, 2018): 18. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.23999.

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The introduction of a new moiety of drugs for antibiotics in the market is getting declined. Antibiotic resistance is a major threat to human health worldwide. Many life-saving antibiotic drugs are rendered ineffective. Resistant bacterial infections are difficult to treat because of the poor response to antibiotics. Hence, utilizing the novel methods/approaches for the development of formulation into its novel delivery can prevent bacterial resistance. This review article explores the various promising approaches for delivery of antibiotics in the form of liposomes, solid lipid nanoparticles, microspheres, dendrimers, inhaled antibiotics, and polymeric particles. These approaches of delivery have been proven to provide innovative and novel delivery of antibiotic by enhancing the therapeutic effectiveness, targeting at the site of action, enhanced activity, and penetrability at intracellular pathogens, thereby reducing side effects, toxicity, and the chances of bacterial resistance.
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Wong, Wendy S. W., Priya Sabu, Varsha Deopujari, Shira Levy, Ankit A. Shah, Nicole Clemency, Marina Provenzano, et al. "Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome." Microorganisms 8, no. 2 (January 27, 2020): 179. http://dx.doi.org/10.3390/microorganisms8020179.

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The meconium microbiome may provide insight into intrauterine and peripartum exposures and the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by microbiome dependent mechanisms. However, there is little data regarding associations of prenatal or peripartum antibiotic exposure, with or without cesarean section (CS), with the features of the meconium microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA of meconium samples from 105 infants in a birth cohort study. After multivariable adjustment, delivery mode (p = 0.044), prenatal antibiotic use (p = 0.005) and peripartum antibiotic use (p < 0.001) were associated with beta diversity of the infant meconium microbiome. CS (vs. vaginal delivery) and peripartum antibiotics were also associated with greater alpha diversity of the meconium microbiome (Shannon and Simpson, p < 0.05). Meconium from infants born by CS (vs. vaginal delivery) had lower relative abundance of the genus Escherichia (p < 0.001). Prenatal antibiotic use and peripartum antibiotic use (both in the overall analytic sample and when restricting to vaginally delivered infants) were associated with differential abundance of several bacterial taxa in the meconium. Bacterial taxa in the meconium microbiome were also differentially associated with infant excess weight at 12 months of age, however, sample size was limited for this comparison. In conclusion, prenatal and peripartum antibiotic use along with CS delivery were associated with differences in the diversity and composition of the meconium microbiome. Whether or not these differences in the meconium microbiome portend risk for long-term health outcomes warrants further exploration.
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Karr, Jeffrey C. "Lower-Extremity Osteomyelitis Treatment Using Calcium Sulfate/Hydroxyapatite Bone Void Filler with Antibiotics." Journal of the American Podiatric Medical Association 108, no. 3 (May 1, 2018): 210–14. http://dx.doi.org/10.7547/16-096.

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Background: Over a 74-month period (∼6 years), 143 lower-extremity osteomyelitis locations in 125 patients were treated with a calcium sulfate/hydroxyapatite liquid bone void filler with antibiotic(s). Methods: The osteomyelitis locations were treated with a percutaneous antibiotic delivery technique delivering intraosseous antibiotic followed by either oral or intravenous antibiotics for 4 weeks. Results: There was no recurrence of osteomyelitis in 96.15% of the treatable patients. Outcomes classified by the Cierny-Mader clinical classification are discussed as well. Conclusions: A bone void filler with antibiotic(s) using the percutaneous antibiotic delivery technique is a safe, reliable, and effective means to treat lower-extremity osteomyelitis with either oral or intravenous antibiotics for 4 weeks.
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Karmila, Ariesti, Mohammad Zulkarnain, Abarham Martadiansyah, Putri Mirani, Nuswil Bernolian, Joseph C. Gardiner, and Lixin Zhang. "The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia." Antibiotics 10, no. 8 (August 19, 2021): 1004. http://dx.doi.org/10.3390/antibiotics10081004.

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Prophylactic antibiotic usage during delivery is a common practice worldwide, especially in low- to middle-income countries. Guidelines have been published to reduce antibiotic overuse; however, data describing the use of prophylactic antibiotics and clinician adherence to guidelines in low- to middle-income countries remain limited. This study aimed to describe the prevalence of prophylactic antibiotic use, factors associated with its use, and clinician adherence to guidelines. A retrospective review was conducted for all deliveries from 1 January 2016 to 31 December 2018 at a tertiary level hospital in Indonesia. The prevalence of prophylactic antibiotic use during delivery was 47.1%. Maternal education level, Ob/Gyn specialist-led delivery, a history of multiple abortions, C-section, premature membrane rupture, and antepartum hemorrhage were independently associated with prophylactic antibiotic use. Clinician adherence to the guidelines was 68.9%. Adherence to guidelines was the lowest in conditions where the patient had only one indication for prophylactic antibiotics (aOR 0.36, 95% CI 0.24–0.54). The findings showed that the prevalence of prophylactic antibiotic use during delivery was moderate to high. Adherence to local guidelines was moderate. Updating the local prescribing guidelines may improve clinician adherence.
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Kumar, TS Sampath, and K. Madhumathi. "Antibiotic delivery by nanobioceramics." Therapeutic Delivery 7, no. 8 (August 2016): 573–88. http://dx.doi.org/10.4155/tde-2016-0025.

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Dissertations / Theses on the topic "Antibiotic delivery"

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Nikam, Shantanu P. "LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA)." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122.

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Stauber, Zachary Jason. "Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/76127.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 51-53).
Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system through the skin, thus avoiding first pass metabolism and allowing more focused delivery to specific viral or bacterial reservoirs. Furthermore, microneedles present other advantages in the form of the ability to be self-administered, tunable controlled release, and painless administration. Saquinavir and Ciprofloxacin, an antiretroviral and an antibiotic respectively, were chosen for their optimal properties, including bioavailability, half-life, and dosage. Saquinavir was encapsulated in the organic phase of biodegradable poly(lactide-co-glycolide) microparticles (MP) synthesized through a double emulsion. Similarly, Ciprofloxacin was encapsulated in the aqueous phase of the microparticles. In addition, Ciprofloxacin microcrystals were synthesized. The microparticles and microcrystals were then loaded into molded polymer microneedles in a poly-acrylic acid (PAA) matrix. Standard curves were created for the two drugs from known concentrations and used to show the drug loading in the microparticles and microneedles. The Saquinavir microparticles showed a maximum loading of 1.35% the mass of particles and the Ciprofloxacin microparticles showed a maximum loading of 0.197%. The Saquinavir microparticle microneedles had a maximum loading of 11.95 [mu]g of Saquinavir per 1 cm² array and the Ciprofloxacin microparticle microneedles had a maximum loading of .41 [mu]g of Ciprofloxacin per 1 cm² array. The Ciprofloxacin microcrystal microneedlees had a maximum loading of 165 [mu]g per 1 cm² array. Analysis based on insulin delivery through microneedles showed these loadings to be too low to create the sufficient minimum drug concentration in plasma. However, there exist multiple strategies to increase the loading of the drugs in the microneedles. These results proved promising for the use of microneedles for the delivery of antiretroviral and antibiotic drugs.
by Zachary Jason Stauber.
S.B.
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Escher, Geraldine. "Cellular delivery using peptoid carriers." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/12260.

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Efficient delivery into cells is essential for many applications. However, cellular access of “cell-impermeable” molecules, such as drugs, sensors, proteins and oligonucleotides, can often be severely limited due to the plasma membrane which protects cells from unregulated influx of hydrophilic materials. In order to solve this issue, several physical techniques and bio-chemical products are today available. One of them is called peptoids (N-alkylglycines). These compounds are peptidomimetics which are resistant to enzymatic degradation, non-immunogenic and are readily prepared by an Fmoc chemical approach. Peptoids based on the "TAT"-peptide (RKKRRQRRR) offer rapid cellular uptake/delivery and low cytotoxicity. In this thesis, based on previous works using fluorescein-cationic peptoids, various fluorescent N-substitued glycines (lysine-like) were prepared by the monomer method followed by solid-phase synthesis. Their cellular uptakes in vitro into several cell lines (such as HeLa, B16F10, HEK293T and primary immune cells) were examined via flow cytometry and microscopy. The cellular delivery of small molecules mediated by the 9mer polymer achieved an efficient and rapid penetration. These results open up a vast number of applications for delivery of macromolecules using nonalysine-like peptoid. In order to demonstrate this ability, the nonalysinelike carrier was used to deliver various biopolymer molecules such as peptides, GFP protein and DNA (in collaboration with Dr. Stefano Caserta). In addition, thanks to the non-cytotoxicity of this cellular transpoter (MTT assays); experiments were carried out in vivo in mice using peptoids labelled near-infrared dyes. The first results have shown that the peptoid is not toxic for the mouse and does not block cell movements. These results allowed the use of 9mer-peptoid as a cellular tracking agent. Based on the development on antimicrobial peptides, the polylysine-like peptoid was also tested as an antibiotic. Recent experiments carried out in collaboration with Dr. Kevin Dhaliwal have revealed a new antimicrobial property of the peptoids. In vitro and in vivo studies have been carried out using both gram positive and negative bacteria. These results present a promising alternative to conventional antibiotics and antimicrobial peptides (AMPs).
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Dallal, Bashi Yahya Haseeb Yahya. "Development of liposomes as pharmaceutical carriers for antibiotic and gene delivery." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725746.

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An inhaled dry powder azithromycin liposomal formulation for the treatment of cystic fibrosis (CF) lung infection was developed based on a previously developed liposome composition by Yusuf (2014). The formulation contains liposomes composed of dimethyldioctadecylammonium bromide, soy-phosphatidylcholine, tocopherol polyethylene glycol 1000 succinate, antibiotic drug azithromycin and pharmaceutical excipients trehalose and L-leucine. A spray-drying method was. optimized and used to produce adry respirable powder product with a low range of water content, a high glass transition (Tg) value. After spray drying the liposomes within the formulation exhibited an average liposome size of less than 120 nm, a size uniformity of 0.3, a zeta potential value of more than +60 mV, an encapsulation efficiency of more than 50% and a prolonged drug release profile. This liposomal formulation enhanced the anti-biofilm activity of azithromycin by 2- to 8-fold against pseudomonal biofilms grown from bacterial strains obtained from the sputum of CF patients. The most promising formulation exhibited good stability profiles over two months at 40 C and one year at 20 C. The formulation showed rapid delivery into bacterial cells, and fast interaction with human cells with no cytotoxic effect in an in vitro setting. The dry-loaded liposomal formulation showed a good cellular uptake following administration to mice via various routes of administration. The in vitro respiratory deposition pattern for this powder formulation was evaluated by performing a next generation impactor (NGI) deposition test using the Aerolizer dry powder inhaler device. The parameters of NGI test were adjusted to mimic the inhalation profile in CF patients. Together, NGI results and the above data indicated that this formulation could potentially be a good inhaled azithromycin delivery system to improve the lung function in CF patients. For gene therapy purpose, a freeze-dried formulation was developed using the same liposome components but loaded with plasmid DNA (pDNA). Following the optimzation of liposome to pDNA ratio, in vitro transfection at lipid to pDNA ratios of 4.7:1 to 9.4:1 was conducted with no cytotoxic effect. In mice, the liposome-pDNA complexes showed local and systemic gene expression that was detectable 48 hours post administration via the intramuscular, intraperitoneal, intravenous and intranasal route. The lyophilized liposome-pDNA complexes exhibited accepted Tg and water content values, that could be optmized further. Finally, these results support the possibility of using this efficient, safe and affordable liposomal formulation in delivering different active compounds for both antibiotic and gene delivery purposes.
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Mandavyapuram, Hima Bindu. "ANTIBIOTIC DELIVERY SYSTEM FOR SURGICAL SITE INFECTION PREVENTION IN SPINAL IMPLANT SURGERY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275624787.

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Thompson, Marc Aaron. "Keratin Microparticles for Drug and Cell Delivery." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89345.

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Keratins are a family of proteins found within human hair, skin and nails, as well as a broad variety of animal tissue. Prior research suggests hydrogel constructs of keratin and keratin derivatives exhibit several mechanical and biological properties that support their use for tissue engineering and regenerative medicine applications. Microparticle formulations of these hydrogels are an intriguing delivery vehicle for drugs and cellular payloads for tissue engineering purposes due to the ability to exploit size, surface area, loading potential and importantly, non-invasive delivery (i.e. injection) of cells and biologics. Here we examine the water-in-oil emulsion synthesis procedure to produce keratin microparticles using an oxidized keratin derivative, keratose (KOS). Analyses of particle size, microstructure, and other characterization techniques were performed. Drug loading characteristics, release kinetics, and feasibility of use in two different microparticles was subsequently investigated, first using a model-drug and later testing an antibiotic payload on bacterial cultures to validate antibacterial applications. A suspension culture technique was developed to load bone marrow-derived mesenchymyal stromal cells (BM-MSCs), testing the capacity to maintain viability and express key protein-based factors in cell growth and development. Finally, we tested the in vitro effects of cell-loaded microparticles on the L6 skeletal muscle cell line to determine potentially beneficial outcomes for skeletal muscle tissue regeneration. Largely spherical particles with a porous internal structure were obtained, displaying hydrogel properties and forming viscoelastic gels with small differences between synthesis components (solvents, crosslinkers), generating tailorable properties. The uniquely fibrous microstructure of KOS particles may lend them to applications in rapid drug release or other payload delivery wherein a high level of biocompatibility is desired. Data showed an ability to inhibit bacterial growth in the emulsion-generated system, and thereby demonstrated the potential for a keratin-based microparticle construct to be used in wound healing applications. Dense cell populations were loaded onto particles. Particles maintained cell viability, even after freeze-thaw cycling, and provided a material substrate that supported cell attachment through the formation of focal adhesions. Finally, in vitro studies show that both KOS and BM-MSCs support varying aspects of skeletal muscle development, with combinatorial treatments of cell-loaded particles conferring the greatest growth responses.
Doctor of Philosophy
Keratins and keratin hydrogels may exhibit several properties that support their use for tissue engineering and regenerative medicine applications. Microparticle formulations of these hydrogels are an intriguing delivery vehicle for payloads for tissue engineering purposes. Here we examine the water-in-oil emulsion synthesis procedure to produce keratin microparticles that were analyzed based on drug loading characteristics. A suspension culture technique was developed to load bone marrow-derived mesenchymyal stromal cells (BM-MSCs). Finally, we tested these products to determine potentially beneficial outcomes for skeletal muscle tissue regeneration. Particles with a porous structure were obtained. The microstructure of these particles may lend them to applications in drug release or other payload delivery. Data showed an ability to load and unload specific drug payloads. Dense cell populations were loaded onto particles. Finally, studies show that both keratin and BM-MSCs support skeletal muscle development, with combinatorial treatments of cell-loaded particles conferring the greatest growth responses.
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Wayakanon, Kornchanok. "Polymersome-mediated intracellular antibiotic delivery to treat Porphyromonas gingivalis-infected oral epithelial cells." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544178.

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Urbaniak, Michael Daniel. "Structural studies of binding to apo-neocarzinostatin." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390819.

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Wang, Yang. "Antibiotic-conjugated polyacrylate nanoparticles : new opportunities for development of anti-MRSA agents." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001446.

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Meng, Hanyan. "DEVELOPMENT OF HUMAN HAIR KERATIN BIOMATERIALS FOR ANTIBIOTIC DELIVERY IN TREATMENT OF ACUTE BACTERIAL INFECTIONS." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1377184680.

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Books on the topic "Antibiotic delivery"

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Vekshin, N. L. Biophysics of DNA-antibiotic complexes. Hauppauge, N.Y: Nova Science Publishers, 2010.

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1948-, Priebe Waldemar, and American Chemical Society. Division of Carbohydrate Chemistry., eds. Anthracycline antibiotics: New analogues, methods of delivery, and mechanisms of action. Washington, DC: American Chemical Society, 1995.

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Bedford, Michael R., Gary G. Partridge, Milan Hruby, and Carrie L. Walk, eds. Enzymes in farm animal nutrition. 3rd ed. Wallingford: CABI, 2022. http://dx.doi.org/10.1079/9781789241563.0000.

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Abstract This third edition explores considerable advances such as the use of enzymes in fish and shrimp diets, new understanding of how phytases function in the animal, NSPase research and enzymes' extended use in ruminant markets. This book also provides comprehensive coverage of all topics relating to the production, use, cooperativity and analysis of feed enzymes. It is fully updated throughout, revealing significant developments such as new methods to deliver enzymes (formulations, encapsulations, and liquid spray systems) and advances in enzyme analysis. It also includes brand new chapters on combinations of enzymes, antibiotic-free diets and how to measure response in feed-enzyme trials. Covering biochemistry, enzymology and characteristics relevant to animal feed use, this book forms a valuable resource for academics and students of animal nutrition and production, as well as professionals in the animal feed industry.
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Ball, Jonathan. Antimicrobial stewardship in the intensive care setting. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198758792.003.0012.

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Intensive care units (ICUs) care for patients with life-threatening infections and thus harbour reservoirs of pathogenic microorganisms. Furthermore, as a direct consequence of their critical illness/injury, ICU patients commonly have a significant degree of acutely acquired, innate, and adaptive immune system dysfunction. Critically ill patients therefore present unique challenges for antibiotic stewardship. Antibiotic stewardship in ICUs should address both the timely delivery of effective empiric therapy and the minimization of the use of broad-spectrum agents. Solutions to these challenges are usually adaptations of general principles rather than novel interventions. In ICUs, as elsewhere, antibiotic stewardship should be viewed as a key component of the overall infection control strategy.
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Le Doare, Kirsty, Christine E. Jones, and Paul T. Heath. Group B Streptococcus (Streptococcus agalactiae). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0019.

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Group B Streptococcus (GBS) is a leading cause of early neonatal infection and neonatal mortality, with long-term adverse neurodevelopmental outcomes in up to 50% of survivors of GBS meningitis. GBS has a likely underappreciated role in causing preterm birth and stillbirth. GBS colonizes the vagina and gastrointestinal tract of the pregnant woman, and transmission to the infant occurs during or just before delivery. Although the majority of these infants do not develop invasive disease, maternal colonization is a prerequisite for early onset disease (0–6 days of life, most commonly associated with sepsis and respiratory distress) and a significant risk factor for late onset disease (7–89 days of life, most commonly associated with sepsis and meningitis). The introduction of intrapartum antibiotic prophylaxis has resulted in significant declines in the incidence of early onset disease but provides no protection against late onset disease.
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Bohnen, John M. A. Liposomal Delivery of Antibiotics in the Treatment of Abdominal Infection. Crc Pr I Llc, 1994.

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Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer, 2014.

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Bobone, Sara. Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer, 2016.

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Bobone, Sara. Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery. Springer London, Limited, 2014.

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Felgueiras, Helena, ed. New Biomolecules and Drug Delivery Systems as Alternatives to Conventional Antibiotics. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4735-0.

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Book chapters on the topic "Antibiotic delivery"

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El-Husseiny, Moataz. "Local Antibiotic Therapy: Non–cement-based Antibiotic Delivery Methods." In Periprosthetic Joint Infections, 125–32. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30091-7_10.

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De Martino, Ivan, Fabio Mancino, Giorgio Cacciola, Vincenzo Di Matteo, and Giulio Maccauro. "Local Delivery of Antibiotic and Antiseptic." In Infection in Knee Replacement, 131–46. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81553-0_13.

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Liu, Xin-Ming, Ke Ren, Geoffrey Wu, and Dong Wang. "Preparation and Evaluation of Biomineral-Binding Antibiotic Liposomes." In Liposome-Based Drug Delivery Systems, 1–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49231-4_17-1.

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Burns, Jessica, Martin McNally, and Janet Conway. "Local Antibiotic Drug Delivery Systems for Musculoskeletal Infections." In Pediatric Musculoskeletal Infections, 133–49. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95794-0_8.

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Miller, Stuart D., Bryan Bean, and Lew C. Schon. "Current Orthopaedic Surgeon Use of Bioresorbable Beads for Antibiotic Delivery." In Antimicrobial Combination Devices, 75–88. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2020. http://dx.doi.org/10.1520/stp163020190140.

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Kim, Jin Hee, Ick Chan Kwon, Yong Hee Kim, Young Taek Sohn, and Seo Young Jeong. "Preparation of Biodegradable Microspheres Containing Water-Soluble Drug, β-Lactam Antibiotic." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 365–66. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_118.

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Prasad, S. Ram, A. Jayakrishnan, and T. S. Sampath Kumar. "Dual Delivery of Antibiotic and Antiresorptive Drugs by Hydroxyapatite-Chitosan Composite Nanocarrier for the Treatment of Osteomyelitis." In Proceedings of the International Conference on Nanomedicine (ICON-2019), 72–85. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-25135-2_8.

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Maki, Yohei. "Antibiotics for Preterm Labor." In Preterm Labor and Delivery, 131–39. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9875-9_13.

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Holland, Sherina, and Simon W. Young. "Local Delivery of Antibiotics." In Essentials of Cemented Knee Arthroplasty, 661–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-63113-3_58.

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Balducci, Anna Giulia, Ruggero Bettini, Paolo Colombo, and Francesca Buttini. "Drug Delivery Strategies for Pulmonary Administration of Antibiotics." In Pulmonary Drug Delivery, 241–62. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118799536.ch11.

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Conference papers on the topic "Antibiotic delivery"

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Michael, Julietta Lady, and Eko Adi Prasetyanto. "Hybrid PVA/alginate for extended delivery of antibiotic." In THE 14TH JOINT CONFERENCE ON CHEMISTRY 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0005241.

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Nafsi, Tabassum, and Paul Kinniry. "Prompt Antibiotic Delivery In Sepsis - A Quality Improvement Project." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2402.

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Zaki, Farzana R., Kavya Sudhir, Jungeun Won, Guillermo L. Monroy, Honggu Choi, Eric J. Chaney, Darold R. Spillman, and Stephen A. Boppart. "3D OCT characterization and quantification of refractive indices of bacteria and biofilms with antibiotic interventions." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2021. http://dx.doi.org/10.1364/omp.2021.otu3d.5.

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Oehler, Madison, Douglas G. Hayes, and Doris D'Souza. "Encapsulation of Melittin in Bicontinuous Microemulsions for Topical Delivery." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fmme7461.

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Surgical site infections and chronic wounds, especially those caused by antibiotic-resistant microorganisms, result in hospitalization and fatalities each year. Methods to prevent these infections, such as cleaning and preparing medical tools, have had minimal success in preventing infections. Further, antibiotic treatments have become less successful in treating infections and wounds as a result of antibiotic-resistant bacteria. Antimicrobial peptides (AMP) are a possible treatment solution. AMPs are oligopeptides that occur in nature or can be synthesized in vitro which possess a broad spectrum of antimicrobial activity against bacteria and other harmful microorganisms. AMPs operate by disrupting the packing arrangements of biomembranes in prokaryotes through their insertion into negatively charged phospholipid bilayers. However, many AMP products have failed clinical trials because of their difficulty to be delivered at high concentrations in an active form. This project proposes the use of bicontinuous microemulsions (BMEs) to encapsulate and deliver AMPs. BMEs are thermodynamically stable monophasic solutions consisting of surfactant, oil, aqueous media, and sometimes a cosurfactant. They are optically clear and consist of surfactant monolayers that separate oil and water nanodomains. Several different BME systems composed of biocompatible oils such as isopropyl myristate and limonene were evaluated for their ability to encapsulate melittin, a model AMP, and to test the system’s antimicrobial activity. AMPs are typically cationic, and the following hypothesis is being tested, that BMEs created with anionic surfactants would induce a more highly folded, hence more biologically active, conformation for melittin. We are currently measuring the antimicrobial activity of BME-encapsulated melittin against several prominent bacteria that are present in chronic wounds and surgical site infections through multiple antimicrobial assays. We will also assess the structure and microenvironment of melittin using circular dichroism and fluorescence spectroscopy, respectively, and the impact of melittin on the structure of BMEs through small-angle X-ray scattering.
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Goodfriend, Amy C., Tré R. Welch, Jian Wang, Kytai T. Nguyen, Romaine F. Johnson, Chet C. Xu, Surendranath R. Veeram Reddy, Alan Nugent, James Richardson, and Joseph M. Forbess. "Design of a MRI-Visible and Radiopaque Drug Delivery Coating for Bioresorbable Stents." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52146.

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Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multi-drug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in a successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.
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Wayakanon, K., M. Thornhill, I. Douglas, G. Battaglia, and C. Murdoch. "Synthesized Polymer Vesicles as Antibiotic Delivery Vehicles for Treating Intracellular Porphyromonas Gingivalis." In IASTED Technology Conferences 2010. Calgary,AB,Canada: ACTAPRESS, 2010. http://dx.doi.org/10.2316/p.2010.707-017.

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Han, X., K. Carey, M. G. Kashiouris, and M. M. Churpek. "Association Between Mortality and Delayed Initial Antibiotic Order and Delivery in Infected and Septic Patients." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6014.

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Borba Cardoso, Mateus, and Murilo Izidoro Santos. "Functionalization of mesoporous silica material (SBA-15-type) with polyether chains as a strategy for controlling antibiotic delivery." In XXIII Congresso de Iniciação Científica da Unicamp. Campinas - SP, Brazil: Galoá, 2015. http://dx.doi.org/10.19146/pibic-2015-38253.

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Wang, Zimeng, and Samantha A. Meenach. "Dry powders based on mucus-penetrating nanocomposite microparticles for pulmonary delivery of antibiotics." In 2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC). IEEE, 2015. http://dx.doi.org/10.1109/nebec.2015.7117136.

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Richens, NC, and C. Clay. "G461(P) Antibiotic therapy in high risk of sepsis emergency department patients – the debate about who should deliver the care." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference and exhibition, 13–15 May 2019, ICC, Birmingham, Paediatrics: pathways to a brighter future. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-rcpch.446.

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Reports on the topic "Antibiotic delivery"

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Bumgardner, Joel D. Dual Delivery of Growth Factors and or Antibiotics from Chitosan-Composites for Bone Regeneration. Fort Belvoir, VA: Defense Technical Information Center, October 2010. http://dx.doi.org/10.21236/ada532903.

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Antibiotics reduce complications after assisted vaginal delivery. National Institute for Health Research, July 2019. http://dx.doi.org/10.3310/signal-000798.

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