Relevant bibliographies by topics / Antibacterial therapeutics

Academic literature on the topic 'Antibacterial therapeutics'

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Published: 6 September 2023

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Journal articles on the topic "Antibacterial therapeutics"

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KUREK, ANNA, ANNA M. GRUDNIAK, ANNA KRACZKIEWICZ-DOWJAT, and KRYSTYNA I. WOLSKA. "New Antibacterial Therapeutics and Strategies." Polish Journal of Microbiology 60, no. 1 (2011): 3–12. http://dx.doi.org/10.33073/pjm-2011-001.

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Studies on new antibacterial therapeutics and strategies are currently being conducted in many microbiological, pharmaceutical and biochemical laboratories. The antibacterial activity of plant-derived compounds as well as silver and gold nanoparticles is the subject of this minireview. The application of photodynamic therapy is also discussed.
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Kern, Thomas J. "Antibacterial agents for ocular therapeutics." Veterinary Clinics of North America: Small Animal Practice 34, no. 3 (May 2004): 655–68. http://dx.doi.org/10.1016/j.cvsm.2003.12.010.

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Liu, Shanshan, Huanxiang Yuan, Haotian Bai, Pengbo Zhang, Fengting Lv, Libing Liu, Zhihui Dai, Jianchun Bao, and Shu Wang. "Electrochemiluminescence for Electric-Driven Antibacterial Therapeutics." Journal of the American Chemical Society 140, no. 6 (February 5, 2018): 2284–91. http://dx.doi.org/10.1021/jacs.7b12140.

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Nagaraj, Nagathihalli S., and Om V. Singh. "Using Genomics to Develop Novel Antibacterial Therapeutics." Critical Reviews in Microbiology 36, no. 4 (July 29, 2010): 340–48. http://dx.doi.org/10.3109/1040841x.2010.495941.

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Allafchian, Alireza, and Seyed Sajjad Hosseini. "Antibacterial magnetic nanoparticles for therapeutics: a review." IET Nanobiotechnology 13, no. 8 (August 29, 2019): 786–99. http://dx.doi.org/10.1049/iet-nbt.2019.0146.

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Gill, Jason J., Taras Hollyer, and Parviz M. Sabour. "Bacteriophages and phage-derived products as antibacterial therapeutics." Expert Opinion on Therapeutic Patents 17, no. 11 (November 2007): 1341–50. http://dx.doi.org/10.1517/13543776.17.11.1341.

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Matthews, Liam, Rupinder K. Kanwar, Shufeng Zhou, Vasu Punj, and Jagat R. Kanwar. "Applications of Nanomedicine in Antibacterial Medical Therapeutics and Diagnostics." Open Tropical Medicine Journal 3, no. 1 (February 24, 2010): 1–9. http://dx.doi.org/10.2174/18743153010030100001.

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Steadman, David, Alvin Lo, Gabriel Waksman, and Han Remaut. "Bacterial surface appendages as targets for novel antibacterial therapeutics." Future Microbiology 9, no. 7 (July 2014): 887–900. http://dx.doi.org/10.2217/fmb.14.46.

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Zhao, Yue, Xiaoyu Wang, Ruilian Qi, and Huanxiang Yuan. "Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics." Polymers 15, no. 15 (August 4, 2023): 3305. http://dx.doi.org/10.3390/polym15153305.

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Hydrogels have a three-dimensional network structure and high-water content, are similar in structure to the extracellular matrix, and are often used as wound dressings. Natural polymers have excellent biocompatibility and biodegradability and are commonly utilized to prepare hydrogels. Natural-polymer-based hydrogels can have excellent antibacterial and bioactive properties by loading antibacterial agents or being combined with therapeutics such as phototherapy, which has great advantages in the field of treatment of microbial infections. In the published reviews of hydrogels used in the treatment of infectious wounds, the common classification criteria of hydrogels include function, source of antibacterial properties, type of antibacterial agent, etc. However, there are few reviews on the classification of hydrogels based on raw materials, and the description of natural-polymer-based hydrogels is not comprehensive and detailed. In this paper, based on the principle of material classification, the characteristics of seven types of natural polymers that can be used to prepare hydrogels are discussed, respectively, and the application of natural-polymer-based hydrogels in the treatment of infectious wounds is described in detail. Finally, the research status, limitations, and prospects of natural-polymer-based hydrogels are briefly discussed.
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Jati, Suborno, Sumana Mahata, Soumita Das, Saurabh Chatterjee, and Sushil K. Mahata. "Catestatin: Antimicrobial Functions and Potential Therapeutics." Pharmaceutics 15, no. 5 (May 20, 2023): 1550. http://dx.doi.org/10.3390/pharmaceutics15051550.

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The rapid increase in drug-resistant and multidrug-resistant infections poses a serious challenge to antimicrobial therapies, and has created a global health crisis. Since antimicrobial peptides (AMPs) have escaped bacterial resistance throughout evolution, AMPs are a category of potential alternatives for antibiotic-resistant “superbugs”. The Chromogranin A (CgA)-derived peptide Catestatin (CST: hCgA352–372; bCgA344–364) was initially identified in 1997 as an acute nicotinic-cholinergic antagonist. Subsequently, CST was established as a pleiotropic hormone. In 2005, it was reported that N-terminal 15 amino acids of bovine CST (bCST1–15 aka cateslytin) exert antibacterial, antifungal, and antiyeast effects without showing any hemolytic effects. In 2017, D-bCST1–15 (where L-amino acids were changed to D-amino acids) was shown to exert very effective antimicrobial effects against various bacterial strains. Beyond antimicrobial effects, D-bCST1–15 potentiated (additive/synergistic) antibacterial effects of cefotaxime, amoxicillin, and methicillin. Furthermore, D-bCST1–15 neither triggered bacterial resistance nor elicited cytokine release. The present review will highlight the antimicrobial effects of CST, bCST1–15 (aka cateslytin), D-bCST1–15, and human variants of CST (Gly364Ser-CST and Pro370Leu-CST); evolutionary conservation of CST in mammals; and their potential as a therapy for antibiotic-resistant “superbugs”.
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Dissertations / Theses on the topic "Antibacterial therapeutics"

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Leire, Eva Emma Maria. "Multifunctional dendrimers for antibacterial applications." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/36191/.

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In this thesis gallic acid-triethylene glycol (GATG) dendrimers were synthesised and efficiently functionalized with hydroxyl groups, phenylboronic acids and primary amines. The interactions of the dendrimers with bacteria and the potential for development of new antimicrobials were evaluated in this study. Specifically, the ability of the dendrimers to induce bacterial clustering and interfere with small molecule autoinducer-2 (AI-2) in the Quorum Sensing (QS) pathway of the marine bacteria V. harveyi was studied with the use of Coulter Counter aggregation assays and detection of QS–controlled luminescence. Novel alkynylated ligands with diol-, tetraol-, glucose- and mannose- moieties were synthesised and successfully functionalized to GATG dendrimers of generation G1 and G3 through catalyst-free azide-alkyne cycloaddition (AAC). The results of luminescence experiments reveled that the dendrimers functionalized with hydroxyl groups decreased AI-2 induced luminescence of V. harveyi MM32 at the at early time points (4 h) while a dose-dependent increase of luminescence and increased bacterial growth was observed at later time points. GATG dendrimers of generation G1 and G3 were decorated with 9 and 81 phenylboronic acid in the periphery. These dendrimers had an inhibitory effect on growth and luminescence as observed by luminescence, aggregation and colony forming unit-counting assays. Although the mechanism is not yet fully understood, these promising results should be further explored. Cationic GATG dendrimers of generation G1, G2 and G3 with 9, 27 and 81 primary amines in the periphery induced formation of clusters in V. harveyi in a generation dependent manner, an improved ability to induce cluster formation when compared with poly(N-[2- (dimethylamino)propyl]methacrylamide), a cationic linear polymer previously shown to cluster bacteria. Viability of the bacteria within the formed clusters and the evaluation of the QS controlled luminescence suggests that the GATG dendrimers may be activating microbial responses by maintaining a high concentration of QS signals inside the clusters while increasing permeability of the microbial outer membrane. Thus, a generation-dependent effect in bacterial luminescence production and membrane permeability was induced by the cationic dendrimers. The inhibition of growth and increased membrane permeability in combination with cell clustering may be promising antibacterial features of these dendrimers. These results highlight the potential of the GATG dendritic platform to develop new antimicrobials aimed to target microbial viability and/or virulence (e.g. adhesion) and encourage further investigations on the importance of polymeric architecture and multivalency in the antimicrobial field.
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Rodolis, Maria T. "Interaction of translocase MraY with the antibacterial E protein from bacteriophage ΦX174." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58786/.

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The widespread use of antibiotics has played a significant role in the emergence of resistant bacteria. It is of great interest and need to develop novel, effective and safe antimicrobial therapeutics. The biosynthesis of bacterial cell wall peptidoglycan is an intricate process that has become a popular target for antibiotics. Lytic protein E of Bacteriophage ΦX174 was found to inhibit peptidoglycan biosynthesis via an unknown interaction with integral protein MraY. Genetic studies have revealed that E-mediated lysis is dependent on the interaction between Phe288 of MraY and the transmembrane segment of protein E. We have constructed an α-helical model for the predicted transmembrane interactions between protein E and MraY and shown that favourable interactions can be formed between Phe288 and the RWXXW motif of protein E. In this thesis, analogues of the RWXXW motif were synthesised in solution and via solid phase peptide synthesis using 2-chlorotrityl chloride resin as the polymeric support. The inhibitory activity of these analogues was determined on a continuous fluorescence assay against membrane bound MraY. Inhibition studies on site-directed mutants of E. coli MraY were also conducted. Testing the inhibitory activity of RWXXW analogues provided compelling information on the importance of protein E residues for the inhibition of MraY. Peptides which contained a tryptophan residue were especially good inhibitors of MraY presumably due to their interaction with Phe288. Mutation of Phe288 caused a dramatic decrease or complete loss to the inhibitory activity of peptides containing an aromatic residue. Some analogues also contained antibacterial activity across multiple strains of bacteria including E. coli, B. subtilis and P. putida with MIC values as low as 8μg/mL. To confirm if MraY was the target enzyme, E. coli cells overexpressing MraY were treated with RWXXW analogues. An increase in the MIC of RWXXW analogues signified that the MraY was the lysis target. In the course of the project, we noticed that members of the UPA class of natural products contained some structural features that are also found in the RWXXW motif. These natural products were tested for activity against site-directed mutants of E. coli MraY. Results showed that Phe288 plays some role in the inhibition of MraY by pacidamycin. This work identifies a promising target for the development of novel antimicrobial agents that is located on the outer face of the cytoplasmic membrane.
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McCully, William Francis. "The antibacterial activity of tea infusions and their effect against the hospital pathogen clostridium difficile." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/52337/.

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Clostridium difficile is one of the UK’s most common hospital acquired infections and there is anecdotal evidence to suggest that the bacteria are sensitive to the antibacterial properties of tea. Surprisingly, little research has been undertaken to characterise the inhibitory activity of aqueous tea infusions that are representative of traditional drinking habits. The antibacterial properties of tea are thought to be due to a group of polyphenols called catechins. However, their contribution to the inhibitory activity of tea infusions and their mechanism of action is still subject to debate. An antimicrobial assay, developed using Staphylococcus aureus as a model organism, was used to determine the antibacterial activity of a range of tea infusions against 75 clinical isolates of C. difficile that represented all the major strain ribotypes over 11 years. Green teas demonstrated more potent antibacterial activity than black teas and their activity was positively correlated with antioxidant power, hydrogen peroxide production, and catechin content. Furthermore, the country of origin of the tea affected the catechin content and subsequent antimicrobial activity of the infusion. Detailed chemical analysis using high performance liquid chromatography and counter current chromatography suggests that the antibacterial activity of tea is probably the result of synergistic interactions between a number of catechins rather than the activity of an individual compound. With regards to the mode of action by which tea inhibits C. difficile, electron microscopy studies of the bacterium treated with green tea revealed distinct changes to the outer cell structures of the bacteria. These changes were indicative of cell membrane blebbing, thus supporting the theory that tea compounds interact with the bacterial membrane and/or cell wall. Overall, this investigation concluded that tea infusions have inhibitory activity against C. difficile in vitro and may be useful in the treatment or prevention of C. difficile infections in vivo.
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Hamilton, A. R. "The development and evaluation of antibacterial polymer-phyllosilicate composite systems for the treatment of infected wounds." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/7684/.

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Clays and clay minerals (phyllosilicates) have been used for millennia to treat a range of human maladies, such as infected wounds and diseases of the skin. The unique chemistry of phyllosilicates allows them to support the wound environment and encourage healing. Their physicochemical properties can also be utilised to develop modified drug-release formulations and also enables their incorporation into polymer matrices for the development of advanced wound care materials. By developing novel antibacterial phyllosilicate-polymer composite materials it should be possible to support wound healing, whilst simultaneously treating infections locally to avoid systemic adverse effects and prevent the development of antimicrobial resistance. In this research project the clay minerals kaolin (KN), refined montmorillonite (rMMT), montmorilonite K10 (MMTK10), Laponite® RD (LRD), and Laponite® XL21 (LXL21) were investigated for their differing structure and physicochemical properties. Their ability to adsorb and desorb the antibacterial agents tetracycline (TC), doxycycline (DC) and ciprofloxacin (CIP) was determined through a series of adsorption kinetics and isotherm studies. LRD and LXL21 were shown to have the highest drug-carrying capacity and were also able to relinquish this drug-load to inhibit the proliferation of key wound pathogens; Staphylococcus epidermidis, Propionibacterium acnes, and Pseudomonas aeruginosa. XRD and FTIR analyses demonstrated that these drug molecules could be adsorbed into the interlayer space and edge groups of the Laponite® particles. LXL21-CIP composites were successfully incorporated into alginate polymer matrices through interaction of the exposed edge-groups on LXL21 and the hydroxyl groups of the alginate to produce novel nanocomposite film and foam materials. Selection of candidate materials was initially undertaken qualitatively with the support of a tissue viability nurse at the Royal Liverpool and Broadgreen University Hospitals NHS Trust. Important properties for wound-dressings such as adsorptive capacity, water vapour transmission rate, and keratinocyte compatibility were measured quantitatively and compared to materials already used for wound care in the UK. Both the film and foam materials were shown to have properties that would be beneficial for wound healing and were also able to release CIP in a controlled manner with notable activity against S. epidermidis, P. acnes, and P. aeruginosa. The nanocomposite film formulation developed in this research project showed promise for future clinical applications and future work should be undertaken to further optimise their manufacture and fully characterise their ability to support the healing of infected wounds. Although the nanocomposite foams require further research, the work presented in this thesis suggests they could also be promising materials for wound care applications.
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chaudhary, Arpana S. "Inhibitors of SecA as Potential Antimicrobial Agents." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/chemistry_diss/77.

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Protein translocation is essential for bacterial survival and the most important translocation mechanism in bacteria is the secretion (Sec) pathway. Thus targeting Sec pathway is a promising strategy for developing novel antibacterial therapeutics. We report the design, syntheses, mechanistic studies and structure-activity relationship studies using HQSAR and 3-D QSAR Topomer CoMFA analyses of 4-oxo-5-cyano thiouracil derivatives. In summary, introduction of polar group such as –N3 and linker groups such as –CH2-O- enhanced the potency as well as logP and logS several fold. We also report the discovery, optimization and structure-activity relationship study of 1,2,4-triazole containing pyrimidines as novel, highly potent antimicrobial agents. A number of inhibitors have been found to inhibit microbial growth at high nanomolar concentrations.
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Tshanga, Siphokazi Sisanda. "Antibacterial activity of liposome encapsulated cyclo(TYR-PRO)." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1450.

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Cyclic dipeptides (CDPs) are amino acid-based compounds, some of which possess antibacterial activity. The encapsulation of certain drugs into liposomes has been found to improve their activity in terms of bioavailability and duration of action. Liposomes are small vesicles that are under investigation as drug carriers for the delivery of therapeutic agents. A number of liposome formulations are currently under clinical trial review, whilst some have already been approved for clinical use. The aim of this study was to optimize a liposomal cyclo(Tyr-Pro) formulation and to assess its antibacterial activity against various Gram-positive and Gram-negative bacteria. Response surface methodology (RSM) using the central composite design (CCD) model was used to optimize liposomal formulations of cyclo(Tyr-Pro) for each of the four bacteria, namely Bacillus cereus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Percent drug encapsulated and bacterial inhibition were investigated with respect to two independent variables, i.e. lipid composition and cholesterol content. Design Expert 8 was used for the purpose of finding the combination of independent variables that would yield an optimal formulation for each bacterium. The model selected by the software failed to adequately correlate the predicted models to the experimental data. The in vitro experiments showed that the antibacterial activity of liposome-encapsulated cyclo(Tyr-Pro) was superior to that of its free counterpart. Binding maximum or Bmax for the encapsulated compound at concentrations as low as 0.412 mg/ml, was significantly higher than that obtained for free cyclo(Tyr-Pro) which was tested at a concentration of 20 mg/ml. Furthermore, encapsulation of cyclo(Tyr-Pro) into a liposome formulation enhanced its potency. This was evident in the lower IC50 values for the liposomal compound when compared to free cyclo(Tyr-Pro).
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Meng, Fan Cheng. "Chemical constituents from the rhizome of coptis chinensis and their antibacterial activities." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953272.

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Konan, N'Zi André. "Estudo farmacognóstico e toxicológico de Anacardium occidentale Linn. (Anacardiaceae) Clone CCP-76." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-01082017-145620/.

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Os extratos totais, assim como os compostos fenólicos isolados de diferentes partes de Anacardium occidentale conhecido popularmente no Brasil como cajueiro mostraram atividades antiúlcera e antibacteriana. O objetivo deste trabalho foi a verificação destas atividades nas folhas, estudo farmacobotânico, químico e toxicológico. Para a analise anatômica foram utilizados cortes do terço mediano inferior da lâmina fotiar. Nesta, as epidermes em vista frontal apresentam cutícula estriada, na face abaxial, a epiderme é constituída de células de formato poligonal, com paredes bem justapostas. Na face adaxial, as células são de paredes espessas, ligeiramente onduladas. A mesma é constituída de estômatos de tipo anomocítico e de tricomas glandulares de forma ovóide. O mesófilo é constituído de duas camadas de parênquima paliçádico, espessas, de forma quase regular e de parênquima lacunoso com células de forma irregular, envolvendo os feixes vasculares de nervuras secundarias. Extensões de fibras são observadas no mesófilo. A nervura mediana possui um colênquima desenvolvido e ductos são encontrados no floema assim como no parênquima medular. Drusas são encontradas no parênquima lacunoso assim como no parênquima fundamental e no colênquima. A partir da triagem fitoquímica, da cromatografia em camada delgada, cromatografia liquida de alta eficiência e cromatografia liquida acoplada a espectrometria de massa, verificou-se a presença nas folhas de cajueiro de compostos polifenólicos, particularmente de heterosídeos flavonóidicos. As estruturas de flavonóide que parecem ser mais evidentes, de acordo com a cromatografia liquida acoplada a massa, são principalmente os heterosídeos da quercetina. O extrato etanol 70% liofilizado das folhas do cajueiro foi submetido ao modelo agudo da úlcera gástrica em ratos e a ensaio antibacteriano, ensaiando as linhagens de Staphylococcus aureus ATCC 25923, Escheríchía coli ATCC 35218 e ATCC 25922, Pseudomonas aerugínosa ATCC 27853 e de Campylobacter coli. Na úlcera aguda, a área relativa de lesão ulcerativa foi diminuída de 98% na dose 400mg/kg, em relação ao controle. A partir de um estudo de doses crescentes sobre a inibição de úlcera, a DE50 foi calculada como 150 mg/kg e as doses de extrato maiores ou iguais a 100 mg/kg exibiram uma inibição de lesão ulcerativa melhor que o lansoprazol 30mg. A fração metanólica, que inibiu as ulcerações de 88,20%, deve conter alguns dos princípios ativos da atividade antiúlcera. Quanto ao teste antimicrobiano, foram obtidas concentrações inibitória mínima e bactericida mínima, iguais a 320 µg/mL, particularmente com a linhagem Staphylococcus aureus, a partir do extrato bruto e da sua fração rica em flavonóides. A partir de ensaio de toxicidade aguda em camundongos e ratos, a DL50 do extrato bruto foi considerada superior a 2000 mg/kg. Foi feito um estudo de toxicidade de administração reiterada em 30 e 90 dias. Baseados em analises bioquímicas para avaliação da função renal e da função hepato-biliar, os parâmetros uréia, creatinina, transaminases, proteína total, albumina, colesterol e cálcio tendem a comprovar que o produto é bem tolerado pelo organismo dos ratos. Este fato é também confirmado pelo estudo hematológico e pela histopatologia, não ocorrendo alterações, após administração subaguda do extrato em ratos. O potencial mutagênico foi avaliado através do teste de Ames e do teste do micronúcleo de medula óssea em camundongo. Foi obtido indício de indução de \"frameshift\" e substituição de pares de bases. Na dose de 2000mg/kg, o extrato de cajueiro parece induzir danos nos cromossomos porém, o fenômeno parece ser extremamente inferior (p<0,001) ao efeito clastogênico induzido pela ciclofosfamida, utilizada como agente mutagênico de referência.
Crude extracts as well as phenolics isolated from the bark or the fruit of Anacardium occidentale popularly known as cajueiro in Brazil, showed antiulcer and antibacterial effects. The aim of this work was to verify those effects in the leaf, botanical, chemical and toxicological studies. Ultrastructure of the leaf was carried on. Cross-sections from the third inferior part of the leaf blade were used. Cashew leaf contains uniseriate epidermis with a sub-eperdimic layer, anomocytic stomata and glandular ovoid trichomes on the inferior surface. The mesophyll exhibits two cell layers of palisadic parenchyma and a lacunose parenchyma containing vascular bundles of the secondary nervures. The median nervure contains a developed collenchyma. Several druses of calcium oxalate are present in the fundamental parenchyma, lacunose parenchyma and in the collenchyma. Resin ducts are also observed in the phloem as well as in the medullar parenchyma. Extensions of sclerenchymatous fibres are observed in the mesophyll. By phytochemical analyses using TLC, HPLC-DAD and positive ions LC-ESIMS, we verified the presence of polyphenols in cashew leaves particularly heterosids of flavonoids. From LC-ESI-MS, evident structures of flavonoids seemed to be heterosids of quercetin. Ethanol 70% extract of cashew leaves was used for antiulcer and antibacterial essays. With extract dose 400mg/kg, ulcer lesions induced by HCL/ethanol 60% in rats, decreased about 98%. By a dose-response effect study, ED50 was evaluated about 150 mg/kg. Extract doses higher than 100mg/kg showed potential of lesion inhibition superior to lansoprazol 30mg. Extract methanolic fraction that gave 88,20% of ulcer inhibition likely contains the principie active of the antiulcer effect. Using bacterial strains, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218 and ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and a clinical isolate Campylobacter coli, for antibacterial essay, the ethanolic extract and one fraction rich in flavonoids were only active in S. aureus with MIC and MBC equal to 320 µg/mL. Acute, 30-day and 90-day subacute toxicity studies were carried out. Crude extract DL50 was superior to 2000mg/kg. Based on biochemical analyses for the evaluation of renal and hepato-biliary functions, level of urea, creatinine, transaminases, total protein, albumin, bilirubin, cholesterol and calcium proved that the extract is biologically tolerated by rat organismo This result was also confirmed by studies in hematology and histopathology. Genotoxity was accessed by Ames test in Salmonella typhimurium strains TA97, TA98, TA100, TA102 and bone marrow micronucleus test in mice. The extract exhibited sign of frameshift and base pairs substitution. Extract dose 2000mglkg seemed to induce damage in the chromosomes however; the activity was extremely inferior to the c1astogenic effect induced by ciclophosphamide.
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Davison, Candace. "The effect of synthetically-derived xanthone compounds on the suppression of the progression of breast cancer and the associated complications." Thesis, Nelson Mandela University, 2017. http://hdl.handle.net/10948/13889.

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Breast cancer is the most frequently diagnosed cancer in women worldwide.A treatment regime, both effective and safe and can only be achieved once more effective chemotherapeutic agents are discovered or identified. These “drugs” must selectively induce cell death such as apoptosis or necroptosis in the cancer cells. Apoptotic cell death allows a cell to “commit suicide” in genetically- controlled or programmed mechanism(s). The microenvironment of the tumour is important since a nurturing malignant environment is required for tumour maintenance, progression and ultimately the development of metastasis. Due to the correlation of the tumour microenvironment to aggressive tumour progression, emphasis should be placed on the constituents of the tumour’s microenvironment. In recent years, the understanding of intracellular pathways in cancer cells has increased rapidly, contributing to the development of drugs with more specific targets such as growth factors, signalling molecules, cell adhesion proteins, proteases, cell-cycle proteins, modulators of apoptosis and molecules that promote angiogenesis and metastasis. The main aim of this study was thus to identify a few potential or active compounds from a library of synthetically-derived compounds as possible alternative breast cancer treatment candidates.
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Sagbo, Idowu Jonas. "Phytochemical analysis and antibacterial properties of aqueous and ethanol extracts of Brachylaena elliptica (Thurb.) dc. and Brachylaena ilicifolia (Lam.) Phill & Schweick." Thesis, University of Fort Hare, 2015. http://hdl.handle.net/10353/d1021289.

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Resistance of human pathogenic bacterial strains results in selective pressure against known antibiotic. However, plant derived compounds that possess antibacterial potential are currently being investigated for treatment of wound infections in diabetic patients as they are inexpensive and non-toxic. Hence, this dissertation was designed to evaluate two medicinal plants (Brachylaena elliptica and Brachylaena ilicifolia) traditionally used in the treatment of various diseases such as diabetes, and its secondary complications in diabetic patients. The in vitro antioxidant activity of both plants were evaluated using DPPH (1, 1-diphenylhydrazl), ferric reducing power, ABTS (2, 2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid), NO (nitric oxide) and H2O2 (hydrogen peroxide) techniques. The antibacterial test and Minimum inhibitory concentration (MIC) was determined by agar dilution method against 5 bacteria strains (Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogene, Proteus vulgaris and Proteus mirabilis) infecting wounds in diabetic patients using amoxicillin and ciprofloxacin as positive control. The phytochemical analyses were assessed using standard published methods. Identification of bioactive components in essential oils of both plants were assessed using GCMS. The aqueous and ethanol extracts of both plants were also evaluated to identify bioactive components using LC-MS. The results of the phytochemical analysis revealed the presence of phenols, tannins, flavanoids, flavanols, proanthocyanidins, saponins and alkaloids in both plants. Both plants indicated strong antioxidant activities which might be due to the presence of bioactive compounds. The aqueous and ethanol leaf extracts of both plants demonstrated appreciable broad spectrum activities against these wound pathogens with MIC ranging between 5 and 0.3 mg/ml. The GC-MS analysis of the essential oils of both plants revealed the presence of monoterpenes, oxygenated sesquiterpenes, phenolics and esters. The LC-MS analysis of the aqueous and ethanol leaf extracts of both plants showed that both plants are rich in alkaloids, terpenes, terpenoids, monoterpernoids, and flavanoids. Conclusively, this study has partially justified the ethnomedicinal use of B. elliptica and B.licifolia leaves for the treatment of various diseases, including diabetes and wound infections caused by bacteria in diabetic patients. These may be attributed to the presence of antioxidant compound such as phenols, flavanoids, saponins, tannins, alkaloids and other phytochemical compounds.
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Books on the topic "Antibacterial therapeutics"

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Enzybiotics: Antibiotic enzymes as drugs and therapeutics. Hoboken, N.J: John Wiley & Sons, 2010.

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Kaushik, Purushottam. Haridra (Turmeric): Antibacterial potential. Varanasi: Chowkhamba Sanskrit Series Office, 2003.

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McDonald, Claire. Cecropins: A class of lytic peptides : promising antibacterial and antitumor activity. Seattle, Wash: Distributed by National Cancer Coalition, 1997.

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Ray, A. B. Medicinal properties of plants: Antifungal, antibacterial, and antiviral activities. Lucknow: International Book Distributing Co., 2004.

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W, Stille, ed. Antibiotics in the tropics: Antibacterial therapy with limited resources. Berlin: Springer-Verlag, 1988.

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Antibiotics basics for clinicians: Choosing the right antibacterial agent. Philadelphia: Lippincott Williams & Wilkins, 2007.

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Antibiotic basics for clinicians: The ABCs of choosing the right antibacterial agent. 2nd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2013.

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A, Kucers, ed. The use of antibiotics: A clinical review of antibacterial, antifungal, and antiviral drugs. 5th ed. Oxford: Butterworth-Heinemann, 1997.

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File, Thomas. New insights in the treatment of severe infections in the multiple-drug resistant situation: Proceedings of a satellite symposium to the 11th International Congress on Infectious Diseases, Cancun, Mexico, March 5, 2004. Basel, Switzerland: Karger, 2004.

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Lesch, John E. The first miracle drugs: How the sulfa drugs transformed medicine. New York, NY: Oxford University Press, 2005.

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Book chapters on the topic "Antibacterial therapeutics"

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Bala, Jyoti, Anupam J. Das, and Ajeet Kaushik. "Antibacterial Hydrogels and Their Implications." In Intelligent Hydrogels in Diagnostics and Therapeutics, 123–34. First edition. | Boca Raton, FL : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781003036050-9.

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Bakker-Woudenberg, Irma A. J. M., Gerrit Storm, and Martin C. Woodle. "Antibacterial Therapy with Sterically Stabilized Liposome Formulations." In Long Circulating Liposomes: Old Drugs, New Therapeutics, 177–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-22115-0_12.

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Arshad, Farwa, Md Palashuddin Sk, and Manab Deb Adhikari. "Metallic Nanoparticles and Their Composites as Alternative Antibacterial Therapeutics." In Alternatives to Antibiotics, 329–53. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1854-4_13.

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Puri, Madhu, Trinad Chakraborty, and Helena Pillich. "Autophagy: A Potential Antibacterial Therapeutic Target." In Infectious Diseases and Your Health, 203–14. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1577-0_10.

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Dams, Dorien, and Yves Briers. "Enzybiotics: Enzyme-Based Antibacterials as Therapeutics." In Advances in Experimental Medicine and Biology, 233–53. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-7709-9_11.

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Kastarnova, Elena, Vladimir Orobets, Valeria Shakhova, Ivan Kireev, Olga Sevostyanova, and Elena Grudeva. "Clinical and Therapeutic Effectiveness of Nanoscale Antibacterial Drugs for Veterinary Use." In Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East (AFE-2021), 212–21. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-91405-9_23.

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Vicari, F., P. Franck, M. C. Conroy, L. Marchal, A. Lozniewski, M. Joubert-Collin, S. Forestier, B. Foliguet, P. Nabet, and M. Weber. "Antibacterial Properties of Some Metal Salts and Lansoprazole against Helicobacter pylori Using MIC Determination, Electron Microscopy and Flow Cytometry Analysis." In Therapeutic Uses of Trace Elements, 253–57. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0167-5_44.

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Pradeepkumar, P. I., and Claudia Höbartner. "RNA-Cleaving DNA Enzymes and Their Potential Therapeutic Applications as Antibacterial and Antiviral Agents." In From Nucleic Acids Sequences to Molecular Medicine, 371–410. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_15.

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Rao, G. S. "Therapeutic Rationalization of Antibacterial Drug Doses in Aquaculture by Using Pharmacokinetic (PK)–Pharmacodynamic (PD) Indices to Contain the Antimicrobial Resistance." In Handbook on Antimicrobial Resistance, 1–15. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-9723-4_34-1.

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Rao, G. S. "Therapeutic Rationalization of Antibacterial Drug Doses in Aquaculture by Using Pharmacokinetic (PK)–Pharmacodynamic (PD) Indices to Contain the Antimicrobial Resistance." In Handbook on Antimicrobial Resistance, 727–41. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9279-7_34.

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Conference papers on the topic "Antibacterial therapeutics"

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Tavares, Tânia D., Joana C. Antunes, Jorge Padrão, Ana I. Ribeiro, Andrea Zille, M. Teresa P. Amorim, Fernando Ferreira, and Helena P. Felgueiras. "Antibacterial Activity of Specialized Biomolecules." In 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecbm2020-08819.

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Cuando-Espitia, Natanael, Crysthal Alvarez, Valeria Garcia, and Guillermo Aguilar. "Antibacterial studies of ZnO nanoparticle coatings on nanocrystalline YSZ irradiated with femtosecond laser light." In Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018, edited by Brian J. F. Wong, Justus F. Ilgner, and Max J. Witjes. SPIE, 2018. http://dx.doi.org/10.1117/12.2289412.

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Antunes, Joana C., Natália C. Homem, Marta A. Teixeira, M. Teresa P. Amorim, Helena P. Felgueiras, and Tânia Tavares. "Antibacterial activity of marine-derived chitosan and plant-derived cajeput oil as loaded blended films in <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em>-enriched settings." In 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecbm2020-08580.

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Birtane, Hatice, and Aslı Beyler Çiğil. "Edible film production with aloe vera extract and its printability." In 11th International Symposium on Graphic Engineering and Design. University of Novi Sad, Faculty of technical sciences, Department of graphic engineering and design, 2022. http://dx.doi.org/10.24867/grid-2022-p47.

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The main concern with protecting fruits and vegetables from bacterial infection and growth is ensuring product quality and safety. Hydroxyethyl cellulose, with –OH in the natural cellulose molecule substituted by a hydroxyethyl group, has been widely used in oil exploitation, coating, medicine, food and polymerization process. It is nontoxic and low-cost. Aloe vera is a well-known herbal plant that is used for its therapeutic properties. The gel extracted from Aloe vera plants contains a variety of biologically active compounds, phenolic contents, and minerals. In this study, the edible films containing different proportions of aloe vera and hydroxyl ethyl cellulose were prepared. The structural and antibacterial properties of the obtained edible films were examined. The obtained films were printed with inkjet. Color and adhesion properties of printed samples were determined and it was observed that the edible films showed antibacterial properties.
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Masruri, Masruri, Muchammad Abdi Baihaqi, Slamet Riyanto, and Arie Srihardyastutie. "Improving antibacterial activity of Spathodea campanulata Beauv’s water extract with copper nanoparticle on Staphylococcus aureus." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978088.

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Setyawati, Amri, Tutik Dwi Wahyuningsih, and Bambang Purwono. "Synthesis and characterization of novel benzohydrazide as potential antibacterial agents from natural product vanillin and wintergreen oil." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978194.

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Fauzi’ah, Lina, and Tutik Dwi Wahyuningsih. "Synthesis of 1-phenyl-3-(4’-nitrophenyl)-5-(3’,4’-dimethoxy-6’-nitrophenyl)-2-pyrazoline and its antibacterial activity." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978124.

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Fitri, Noor, Ifat Fatimah, Lutfi Chabib, and Febi Indah Fajarwati. "Formulation of antiacne serum based on lime peel essential oil and in vitro antibacterial activity test against Propionibacterium acnes." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978196.

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Lapitsky, Yakov, Sabrina Alam, Udaka de Silva, Jennifer Brown, Carolina Mather, and Youngwoo Seo. "Surfactant-loaded Polyelectrolyte/multivalent Ion Coacervates for the Multi-month Release of Antibacterial and Therapeutic Payloads." In Virtual 2021 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2021. http://dx.doi.org/10.21748/am21.267.

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Chairunnisa, Hady Anshory Tamhid, and Arde Toga Nugraha. "Gas chromatography – Mass spectrometry analysis and antibacterial activity of Cinnamomum burmanii essential oil to Staphylococcus aureus and Escherichia coli by gaseous contact." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978146.

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Reports on the topic "Antibacterial therapeutics"

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Cabrera, Anahi Maldonado, Blayra Maldonado Cabrera, Dalia Isabel Sánchez Machado, and Jaime López Cervantes. Wound healing therapeutic effect of chitosan nanofibers: a systematic review and meta- analysis of animal studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0121.

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Review question / Objective: Review question: Does chitosan base nanofibers has significant wound healing therapeutics effects in animal models? A preclinical systematic review of intervention will be carried out to evaluate the therapeutic effects of chitosan nanofibers on animal skin lesions. The PICO (Population, Intervention, Comparator, Outcome) scheme will be used: Intervention: full-thickness skin lesions, and the application of chitosan nanofibers as treatment for animal skin lesions. Regardless of the concentration of chitosan or other added compounds used. Comparison: No intervention, topical placebo agents and standard skin lesions treatments will be included. Outcome: wound healing area, wound closure, type of wound closure (first, second or third intention), healing time, infectious processes (antibacterial/antifungal properties), blood loss (hemostatic properties) and adverse effects.
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