Journal articles on the topic 'Antibacterial hydrogels'
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1
Li, Shuqiang, Shujun Dong, Weiguo Xu, Shicheng Tu, Lesan Yan, Changwen Zhao, Jianxun Ding, and Xuesi Chen. "Antibacterial Hydrogels." Advanced Science 5, no. 5 (February 22, 2018): 1700527. http://dx.doi.org/10.1002/advs.201700527.
2
Peng, Tai, Qi Shi, Manlong Chen, Wenyi Yu, and Tingting Yang. "Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review." Journal of Functional Biomaterials 14, no. 5 (April 25, 2023): 243. http://dx.doi.org/10.3390/jfb14050243.
Abstract:
Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.
3
Rao, Kummara Madhusudana, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi, and Sung Soo Han. "Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels." Pharmaceutics 14, no. 5 (May 10, 2022): 1028. http://dx.doi.org/10.3390/pharmaceutics14051028.
Abstract:
In this work, fungal mushroom-derived carboxymethyl chitosan-polydopamine hydrogels (FCMCS-PDA) with multifunctionality (tissue adhesive, hemostasis, self-healing, and antibacterial properties) were developed for wound dressing applications. The hydrogel is obtained through dynamic Schiff base cross-linking and hydrogen bonds between FCMCS-PDA and covalently cross-linked polyacrylamide (PAM) networks. The FCMCS-PDA-PAM hydrogels have a good swelling ratio, biodegradable properties, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were formed along with FCMCS fibers in the hydrogel networks, which has a high impact on the biological performance of hydrogels. The maximum adhesion strength of the hydrogel to porcine skin was achieved at about 29.6 ± 2.9 kPa. The hydrogel had good self-healing and recoverable properties. The PDA-containing hydrogels show good antibacterial properties on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. Moreover, the adhesive hydrogels depicted good viability and attachment of skin fibroblasts and keratinocyte cells. Importantly, FCMCS and PDA combined resulted in fast blood coagulation within 60 s. Hence, the adhesive hydrogel with multifunctionality has excellent potential as a wound dressing material for infected wounds.
4
He, Weizhong, Yajuan Zhu, Yan Chen, Qi Shen, Zhenyu Hua, Xian Wang, and Peng Xue. "Inhibitory Effect and Mechanism of Chitosan–Ag Complex Hydrogel on Fungal Disease in Grape." Molecules 27, no. 5 (March 4, 2022): 1688. http://dx.doi.org/10.3390/molecules27051688.
Abstract:
Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface. The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields. However, there have been few reports on its application for controlling postharvest diseases in fruit. In this study, the Chitosan–silver (CS–Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape. The prepared hydrogels were stable for a long period at room temperature. The structure and surface morphology of CS–Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD. The inhibitory effects of CS–Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro. The remarkable antibacterial activity of CS–Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag. Preservation tests showed that the CS–Ag hydrogel had positive fresh-keeping effect. This revealed that CS–Ag hydrogels can play a critical role in controlling fungal disease in grapes.
5
Wei, Lai, Jianying Tan, Li Li, Huanran Wang, Sainan Liu, Junying Chen, Yajun Weng, and Tao Liu. "Chitosan/Alginate Hydrogel Dressing Loaded FGF/VE-Cadherin to Accelerate Full-Thickness Skin Regeneration and More Normal Skin Repairs." International Journal of Molecular Sciences 23, no. 3 (January 23, 2022): 1249. http://dx.doi.org/10.3390/ijms23031249.
Abstract:
The process of full-thickness skin regeneration is complex and has many parameters involved, which makes it difficult to use a single dressing to meet the various requirements of the complete regeneration at the same time. Therefore, developing hydrogel dressings with multifunction, including tunable rheological properties and aperture, hemostatic, antibacterial and super cytocompatibility, is a desirable candidate in wound healing. In this study, a series of complex hydrogels were developed via the hydrogen bond and covalent bond between chitosan (CS) and alginate (SA). These hydrogels exhibited suitable pore size and tunable rheological properties for cell adhesion. Chitosan endowed hemostatic, antibacterial properties and great cytocompatibility and thus solved two primary problems in the early stage of the wound healing process. Moreover, the sustained cytocompatibility of the hydrogels was further investigated after adding FGF and VE-cadherin via the co-culture of L929 and EC for 12 days. The confocal 3D fluorescent images showed that the cells were spherical and tended to form multicellular spheroids, which distributed in about 40–60 μm thick hydrogels. Furthermore, the hydrogel dressings significantly accelerate defected skin turn to normal skin with proper epithelial thickness and new blood vessels and hair follicles through the histological analysis of in vivo wound healing. The findings mentioned above demonstrated that the CS/SA hydrogels with growth factors have great potential as multifunctional hydrogel dressings for full-thickness skin regeneration incorporated with hemostatic, antibacterial, sustained cytocompatibility for 3D cell culture and normal skin repairing.
6
Xu, Weiguo, Shujun Dong, Yuping Han, Shuqiang Li, and Yang Liu. "Hydrogels as Antibacterial Biomaterials." Current Pharmaceutical Design 24, no. 8 (May 14, 2018): 843–54. http://dx.doi.org/10.2174/1381612824666180213122953.
Abstract:
Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.
7
Chen, Zhuoyue, Min Mo, Fanfan Fu, Luoran Shang, Huan Wang, Cihui Liu, and Yuanjin Zhao. "Antibacterial Structural Color Hydrogels." ACS Applied Materials & Interfaces 9, no. 44 (October 24, 2017): 38901–7. http://dx.doi.org/10.1021/acsami.7b11258.
8
Sun, Ying, Jiayi Wang, Duanxin Li, and Feng Cheng. "The Recent Progress of the Cellulose-Based Antibacterial Hydrogel." Gels 10, no. 2 (January 29, 2024): 109. http://dx.doi.org/10.3390/gels10020109.
Abstract:
Cellulose-based antibacterial hydrogel has good biocompatibility, antibacterial performance, biodegradability, and other characteristics. It can be very compatible with human tissues and degradation, while its good water absorption and moisturizing properties can effectively absorb wound exudates, keep the wound moist, and promote wound healing. In this paper, the structural properties, and physical and chemical cross-linking preparation methods of cellulose-based antibacterial hydrogels were discussed in detail, and the application of cellulose-based hydrogels in the antibacterial field was deeply studied. In general, cellulose-based antibacterial hydrogels, as a new type of biomaterial, have shown good potential in antimicrobial properties and have been widely used. However, there are still some challenges, such as optimizing the preparation process and performance parameters, improving the antibacterial and physical properties, broadening the application range, and evaluating safety. However, with the deepening of research and technological progress, it is believed that cellulose-based antibacterial hydrogels will be applied and developed in more fields in the future.
9
Li, Rongkai, Qinbing Qi, Chunhua Wang, Guige Hou, and Chengbo Li. "Self-Healing Hydrogels Fabricated by Introducing Antibacterial Long-Chain Alkyl Quaternary Ammonium Salt into Marine-Derived Polysaccharides for Wound Healing." Polymers 15, no. 6 (March 15, 2023): 1467. http://dx.doi.org/10.3390/polym15061467.
Abstract:
The development of hydrogels as wound dressings has gained considerable attention due to their promising ability to promote wound healing. However, in many cases of clinical relevance, repeated bacterial infection, which might obstruct wound healing, usually occurs due to the lack of antibacterial properties of these hydrogels. In this study, we fabricated a new class of self-healing hydrogel with enhanced antibacterial properties based on dodecyl quaternary ammonium salt (Q12)-modified carboxymethyl chitosan (Q12-CMC), aldehyde group- modified sodium alginate (ASA), Fe3+ via Schiff bases and coordination bonds (QAF hydrogels). The dynamic Schiff bases and coordination interactions conferred excellent self-healing abilities to the hydrogels, while the incorporation of dodecyl quaternary ammonium salt gave the hydrogels superior antibacterial properties. Additionally, the hydrogels displayed ideal hemocompatibility and cytocompatibility, crucial for wound healing. Our full-thickness skin wound studies demonstrated that QAF hydrogels could result in rapid wound healing with reduced inflammatory response, increased collagen disposition and improved vascularization. We anticipate that the proposed hydrogels, possessing both antibacterial and self-healing properties, will emerge as a highly desirable material for skin wound repair.
10
Yu, Jie, Fangli Ran, Chenyu Li, Zhenxin Hao, Haodong He, Lin Dai, Jingfeng Wang, and Wenjuan Yang. "A Lignin Silver Nanoparticles/Polyvinyl Alcohol/Sodium Alginate Hybrid Hydrogel with Potent Mechanical Properties and Antibacterial Activity." Gels 10, no. 4 (April 1, 2024): 240. http://dx.doi.org/10.3390/gels10040240.
Abstract:
Antibacterial hydrogels have attracted significant attention due to their diverse applications, efficient antimicrobial properties, and adaptability to various environments and requirements. However, their relatively fragile structure, coupled with the potential for environmental toxicity when exposed to their surroundings for extended periods, may significantly limit their practical application potential. In this work, a composite hydrogel was synthesized with outstanding mechanical features and antibacterial capability. The hydrogel was developed through the combination of the eco-friendly and enduring antibacterial agent, lignin silver nanoparticles (Lig-Ag NPs), with polyvinyl alcohol (PVA) and sodium alginate (SA), in varying proportions. The successful synthesis of the hydrogel and the dispersed distribution of Lig-Ag NPs within the hydrogel were confirmed by various analytical techniques, including field emission scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), mercury intrusion porosimetry (MIP), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The formation of multiple hydrogen bonds between Lig-Ag NPs and the composites contributed to a more stable and dense network structure of the hydrogel, consequently enhancing its mechanical properties. Rheological tests revealed that the hydrogel exhibited an elastic response and demonstrated outstanding self-recovery properties. Significantly, the antibacterial hydrogel demonstrated effectiveness against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), achieving a <5% survival of bacteria within 12 h. This study presented a green and straightforward synthetic strategy for the application of antibacterial composite hydrogels in various fields.
11
Zeng, Mingzhu, Zhimao Huang, Xiao Cen, Yinyu Zhao, Fei Xu, Jiru Miao, Quan Zhang, and Rong Wang. "Biomimetic Gradient Hydrogels with High Toughness and Antibacterial Properties." Gels 10, no. 1 (December 21, 2023): 6. http://dx.doi.org/10.3390/gels10010006.
Abstract:
Traditional hydrogels, as wound dressings, usually exhibit poor mechanical strength and slow drug release performance in clinical biomedical applications. Although various strategies have been investigated to address the above issues, it remains a challenge to develop a simple method for preparing hydrogels with both toughness and controlled drug release performance. In this study, a tannic acid-reinforced poly (sulfobetaine methacrylate) (TAPS) hydrogel was fabricated via free radical polymerization, and the TAPS hydrogel was subjected to a simple electrophoresis process to obtain the hydrogels with a gradient distribution of copper ions. These gradient hydrogels showed tunable mechanical properties by changing the electrophoresis time. When the electrophoresis time reached 15 min, the hydrogel had a tensile strength of 368.14 kPa, a tensile modulus of 16.17 kPa, and a compressive strength of 42.77 MPa. It could be loaded at 50% compressive strain and then unloaded for up to 70 cycles and maintained a constant compressive stress of 1.50 MPa. The controlled release of copper from different sides of the gradient hydrogels was observed. After 6 h of incubation, the hydrogel exhibited a strong bactericidal effect on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, with low toxicity to NIH/3T3 fibroblasts. The high toughness, controlled release of copper, and enhanced antimicrobial properties of the gradient hydrogels make them excellent candidates for wound dressings in biomedical applications.
12
Hong, Zhiwu, Lei Wu, Zherui Zhang, Jinpeng Zhang, Huajian Ren, Gefei Wang, Xiuwen Wu, Guosheng Gu, and Jianan Ren. "Self-Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing." Journal of Healthcare Engineering 2023 (February 9, 2023): 1–10. http://dx.doi.org/10.1155/2023/7109766.
Abstract:
Wound healing due to skin defects is a growing clinical concern. Especially when infection occurs, it not only leads to impair healing of the wound but even leads to the occurrence of death. In this study, a self-healing supramolecular hydrogel with antibacterial abilities was developed for wound healing. The supramolecular hydrogels inherited excellent self-healing and mechanical properties are produced by the polymerization of N-acryloyl glycinamide monomers which carries a lot of amides. In addition, excellent antibacterial properties are obtained by integrating silver nanoparticles (Ag NPs) into the hydrogels. The resultant hydrogel has a demonstrated ability in superior mechanical properties, including stretchability and self-healing. Also, the good biocompatibility and antibacterial ability have been proven in hydrogels. Besides, the prepared hydrogels were employed as wound dressings to treat skin wounds of animals. It was found that the hydrogels could significantly promote wound repair, including relieving inflammation, promoting collagen deposition, and enhancing angiogenesis. Therefore, such self-healing supramolecular hydrogels with composite functional nanomaterials are expected to be used as new wound dressings in the field of healthcare.
13
Michalicha, Anna, Anna Tomaszewska, Vladyslav Vivcharenko, Barbara Budzyńska, Magdalena Kulpa-Greszta, Dominika Fila, Robert Pązik, and Anna Belcarz. "Poly(levodopa)-Functionalized Polysaccharide Hydrogel Enriched in Fe3O4 Particles for Multiple-Purpose Biomedical Applications." International Journal of Molecular Sciences 24, no. 9 (April 28, 2023): 8002. http://dx.doi.org/10.3390/ijms24098002.
Abstract:
In recent years, there has been a significant increase in interest in the use of curdlan, a naturally derived polymer, for medical applications. However, it is relatively inactive, and additives increasing its biomedical potential are required; for example, antibacterial compounds, magnetic particles, or hemostatic agents. The stability of such complex constructs may be increased by additional functional networks, for instance, polycatecholamines. The article presents the production and characterization of functional hydrogels based on curdlan enriched with Fe3O4 nanoparticles (NPs) or Fe3O4–based heterostructures and poly(L-DOPA) (PLD). Some of the prepared modified hydrogels were nontoxic, relatively hemocompatible, and showed high antibacterial potential and the ability to convert energy with heat generation. Therefore, the proposed hydrogels may have potential applications in temperature-controlled regenerative processes as well as in oncology therapies as a matrix of increased functionality for multiple medical purposes. The presence of PLD in the curdlan hydrogel network reduced the release of the NPs but slightly increased the hydrogel’s hemolytic properties. This should be taken into account during the selection of the final hydrogel application.
14
Zhu, Jie, Hua Han, Ting-Ting Ye, Fa-Xue Li, Xue-Li Wang, Jian-Yong Yu, and De-Qun Wu. "Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application." Molecules 23, no. 12 (December 19, 2018): 3383. http://dx.doi.org/10.3390/molecules23123383.
Abstract:
The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application.
15
Gopal, Rathosivan, Alex Zhen Kai Lo, Masuriani Masrol, Chian-Hui Lai, Norhidayu Muhamad Zain, and Syafiqah Saidin. "Susceptibility of Stingless Bee, Giant Bee and Asian Bee Honeys Incorporated Cellulose Hydrogels in Treating Wound Infection." Malaysian Journal of Fundamental and Applied Sciences 17, no. 3 (June 29, 2021): 242–52. http://dx.doi.org/10.11113/mjfas.v17n3.2049.
Abstract:
Wound healing and wound management are among challenging clinical problems, despite the advancement in medical technology and research. Honey is one of the natural products, synthesized by honey bees that exhibits great antibacterial and medicinal properties. Incorporation of honey into modern dressing materials such as cellulose hydrogel is beneficial to anticipate cell proliferation while preventing infection in a wound region. This study reports the fabrication of honey cellulose hydrogels for reliable alternative treatment of wound infection. The cellulose hydrogels were incorporated with three types of mainland Southeast Asia honeys of stingless bee, giant bee and Asian bee, independently. Each hydrogel was subjected to ATR-FTIR analysis for the determination of chemical composition. The antibacterial properties of honey hydrogels were evaluated through zone inhibition and colony count tests against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The cytocompatibility of the honey hydrogels was then evaluated through MTT assay and cell scratch assay with human skin fibroblast cells. The composition of honey and cellulose hydrogel were verified with the appearances of fingerprint bandwidth and identical peaks of both compounds, respectively. The giant bee honey hydrogels produced the highest bacterial retardation through both antibacterial tests. The stingless bee honey hydrogels projected susceptibility towards E. coli while the Asian bee honey hydrogels projected susceptibility towards S. aureus. Among these three variations of honey hydrogels, the in-vitro cytocompatibility analyses testified the greatest cell viability and cell migration on the stingless bee honey hydrogels compared to the Asian bee honey hydrogels, giant bee honey hydrogels and control hydrogels. The findings support the potential of honey hydrogels as a reliable alternative treatment for wound infection.
16
Zheng, Jing Jing, and Xiao Liang Gui. "Swelling and Antibacterial Properties of Chitosan/Poly(vinyl alcohol) Hybrid Hydrogels." Applied Mechanics and Materials 672-674 (October 2014): 737–40. http://dx.doi.org/10.4028/www.scientific.net/amm.672-674.737.
Abstract:
Chitosan (CTS) was added into poly (vinyl alcohol) (PVA) hydrogels to get their antibacterial properties. A series of CTS/PVA hybrid hydrogels were prepared by freezing/thawing method. The swelling properties of all hybrid hydrogels are better than those of the original PVA hydrogel. The CTS/PVA hybrid hydrogels show excellent antimicrobial performance towards Escherichia colis.
17
Feyissa, Zerihun, Gemechu Deressa Edossa, Tariku Bayisa Bedasa, and Leta Guta Inki. "Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties." International Journal of Polymer Science 2023 (April 18, 2023): 1–18. http://dx.doi.org/10.1155/2023/1205092.
Abstract:
This research focused on preparing hydrogels with controlled drug release properties to control gastrointestinal tract bacterial infection. Chitosan (CS) and polyvinylpyrrolidone (PVP) were used as the base polymers, with the CS component crosslinked by glutaraldehyde for hydrogel preparation using the solution casting technique. The effect of varying glutaraldehyde content in the hydrogels was characterized by the extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4; the development of porosity; and gel fraction. Functional groups and covalent and hydrogen bonds formed, thermal stability, phase structure, and morphology were characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The results show that the components in the hydrogels have good compatibility and formed honeycomb-like structures. In vitro studies confirmed that the hydrogels have good biodegradability at pH 7.4. Based on these properties, a CS/PVP hydrogel of the ratio of 60 : 40 crosslinked with 600 μL glutaraldehyde was selected for the in-situ loading of 200 mg of the drug metronidazole (MTZ). The hydrogel was characterized for cumulative drug release in the simulated physiological fluids and drug release kinetics using different models and for its antibacterial activity. The best-fit Korsmeyer–Peppas model suggests that MTZ release followed diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This hydrogel displays enhanced antimicrobial activity against Staphylococcus aureus, and Escherichia coli showed substantial inhibition zones indicating the produced CS/PVP hydrogels are promising candidates for controlled drug release applications.
18
Nguyen, Tan Dat, Thanh Truc Nguyen, Khanh Loan Ly, Anh Hien Tran, Thi Thanh Ngoc Nguyen, Minh Thuy Vo, Hieu Minh Ho, et al. "In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications." International Journal of Polymer Science 2019 (March 21, 2019): 1–10. http://dx.doi.org/10.1155/2019/7382717.
Abstract:
Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.
19
Abdollahi, Zahra, Ehsan Nazarzadeh Zare, Fatemeh Salimi, Iran Goudarzi, Franklin R. Tay, and Pooyan Makvandi. "Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo." International Journal of Molecular Sciences 22, no. 5 (March 3, 2021): 2531. http://dx.doi.org/10.3390/ijms22052531.
Abstract:
In this study, nanocomposite hydrogels composed of sodium carboxymethylated starch (CMS)-containing CuO nanoparticles (CMS@CuO) were synthesized and used as experimental wound healing materials. The hydrogels were fabricated by a solution-casting technique using citric acid as a crosslinking agent. They were characterized by Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and thermogravimetric analysis (TGA) to evaluate their physicochemical properties. In addition, swelling, antibacterial activities, antioxidant activities, cytotoxicity, and in vivo wound healing were investigated to evaluate the wound healing potential of the CMS@CuO nanocomposite hydrogels. Growth inhibition of the Gram-positive and Gram-negative pathogens, antioxidant activity, and swelling were observed in the CMS@CuO nanocomposite hydrogels containing 2 wt.% and 4 wt.% CuO nanoparticles. The hydrogel containing 2 wt.% CuO nanoparticles displayed low toxicity to human fibroblasts and exhibited good biocompatibility. Wounds created in rats and treated with the CMS@2%CuO nanocomposite hydrogel healed within 13 days, whereas wounds were still present when treated for the same time-period with CMS only. The impact of antibacterial and antioxidant activities on accelerating wound healing could be ascribed to the antibacterial and antioxidant activities of the nanocomposite hydrogel. Incorporation of CuO nanoparticles in the hydrogel improved its antibacterial properties, antioxidant activity, and degree of swelling. The present nanocomposite hydrogel has the potential to be used clinically as a novel wound healing material.
20
Zhou, Chao, Mengdi Sun, Danni Wang, Mingmei Yang, Jia Ling Celestine Loh, Yawen Xu, and Ruzhi Zhang. "In Vitro Antibacterial and Anti-Inflammatory Properties of Imidazolium Poly(ionic liquids) Microspheres Loaded in GelMA-PEG Hydrogels." Gels 10, no. 4 (April 20, 2024): 278. http://dx.doi.org/10.3390/gels10040278.
Abstract:
Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy of natural agents, and the potential cytotoxicity associated with metal antibacterial nanoparticles in hydrogels hindered their broader clinical application. In this study, we successfully developed imidazolium poly(ionic liquids) (PILs) polymer microspheres (APMs) through emulsion polymerization. These APMs exhibited notable antibacterial effectiveness and demonstrated minimal cell toxicity. Subsequently, we integrated the APMs into a gelatin methacryloyl (GelMA)—polyethylene glycol (PEG) hydrogel. This composite hydrogel not only showcased strong antibacterial and anti-inflammatory properties but also facilitated the migration of human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) and promoted osteogenic differentiation in vitro.
21
Virych, Pavlo, Oksana Nadtoka, Nataliya Kutsevol, Bohdan Krysa, and Vasyl Krysa. "Antibacterial Polyacrylamide and Dextran-Graft-Polyacrylamide Hydrogels for the Treatment of Open Wounds." Galician Medical Journal 29, no. 3 (September 1, 2022): E202235. http://dx.doi.org/10.21802/gmj.2022.3.5.
Abstract:
Background. Open wound treatment requires a use of bandage material to prevent the development of pathogenic microflora and to provide the necessary conditions for tissue regeneration.
The aim of the study was to compare the effectiveness of polyacrylamide (PAA) and dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (AgNPs), antibiotics, and photosensitizers for the treatment of bacterial infection of open wounds.
Materials and Methods. PAA and D-PAA hydrogels with AgNPs, methylene blue (0.001%) without (MB) and with red light irradiation (660 nm) (MB+L), chlorhexidine (0.05%) and cefuroxime (0.1%) were used. There were tested in vitro and in vivo (a rat model) antibacterial activities against wild-type Staphylococcus aureus, Escherichia coli, antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains obtained from the wound. Clinical investigations were performed in patients with chronic venous ulcers of the lower extremities with no response to traditional treatments.
Results. S. aureus, E. coli, and K. pneumoniae strains were sensitive to PAA and D-PAA hydrogels with AgNPs, chlorhexidine, and cefuroxime. Antibiotic-resistant E. coli was not inhibited by the hydrogels with cefuroxime. This strain was less sensitive to chlorhexidine and MB+L. There were no differences between unloaded PAA and D-PAA hydrogels; the antibacterial properties of the dressing were determined by an antibacterial component loaded into the hydrogel. The use of unloaded D-PAA hydrogels in vivo helped reduce the size of the wound by 28.6% and 42.8% three and five days after wound modeling, respectively. Similar results were obtained for D-PAA hydrogels loaded with cefuroxime, chlorhexidine, and MB+L. D-PAA hydrogel with AgNPs reduced wound size by 50% and 62.5% three and five days after wound induction, respectively, demonstrated greater antibacterial activity and was selected for clinical investigations. In a patient, 14 days after bandage application, the fibrin membrane disappeared, the ulcers were covered with pink granulations, marginal epithelialization appeared.
Conclusions. PAA and D-PAA hydrogels can be loaded with the antibacterial compounds of various types. The type of polymer does not affect the antibacterial properties of the final hydrogels. The hydrogels with chlorhexidine and MB+L can be potentially used to treat bacterial contamination of wounds and ulcers. Nevertheless, their disadvantage is the inability to absorb or precipitate tissue breakdown products that interfere with normal regeneration and inflammation. D-PAA/AgNPs are the best option for treating ulcers due to the ability to control the properties of the hydrogels and nanoparticles, as well as multiple mechanisms of antibacterial action.
22
Yu, Ya-Chu, Ming-Hsien Hu, Hui-Zhong Zhuang, Thi Ha My Phan, Yi-Sheng Jiang, and Jeng-Shiung Jan. "Antibacterial Gelatin Composite Hydrogels Comprised of In Situ Formed Zinc Oxide Nanoparticles." Polymers 15, no. 19 (October 3, 2023): 3978. http://dx.doi.org/10.3390/polym15193978.
Abstract:
We report the feasibility of using gelatin hydrogel networks as the host for the in situ, environmentally friendly formation of well-dispersed zinc oxide nanoparticles (ZnONPs) and the evaluation of the antibacterial activity of the as-prepared composite hydrogels. The resulting composite hydrogels displayed remarkable biocompatibility and antibacterial activity as compared to those in previous studies, primarily attributed to the uniform distribution of the ZnONPs with sizes smaller than 15 nm within the hydrogel network. In addition, the composite hydrogels exhibited better thermal stability and mechanical properties as well as lower swelling ratios compared to the unloaded counterpart, which could be attributed to the non-covalent interactions between the in situ formed ZnONPs and polypeptide chains. The presence of ZnONPs contributed to the disruption of bacterial cell membranes, the alteration of DNA molecules, and the subsequent release of reactive oxygen species within the bacterial cells. This chain of events culminated in bacterial cell lysis and DNA fragmentation. This research underscores the potential benefits of incorporating antibacterial agents into hydrogels and highlights the significance of preparing antimicrobial agents within gel networks.
23
Wang, Yangyang, and Yansong Wang. "A Composited Povidone-Iodine Silk Fibroin Hydrogel for Wound Infection." Journal of Biomaterials and Tissue Engineering 9, no. 6 (June 1, 2019): 719–30. http://dx.doi.org/10.1166/jbt.2019.2055.
Abstract:
Wound infections have historically been an important global health concern which seriously affects human life and health. Reducing the number of bacteria at the site of the wound is essential to prevent wound infection and promote wound healing. Povidone-iodine (PVP-I) is widely used as an antiseptic providing useful properties for local anti-infective treatment in skin, mucous membranes, and wounds. In this study, we synthesized a new PVP-I/silk fibroin (SF) hydrogel through a simple preparation method, and to study the physicochemical properties, antibacterial properties and biocompatibility of the composited hydrogel. Compared with the pure SF hydrogel, the composition of PVP-I with SF hydrogels endowed the hydrogel new physicochemical characteristics especially enhanced hydrogel's structural stability and a sustained-release effect of iodine. Moreover, such composited hydrogels showed better antibacterial properties when the content of the compound PVP-I reached a certain degree. In vivo, the results indicate that the composited hydrogel displayed a good histocompatibility and biodegradability. All these results demonstrated that the composited povidone-iodine silk hydrogel can be fabricated as an anti-infective biomaterials with great potential using in wound infection.
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Abd El-Hady, M. M., and S. El-Sayed Saeed. "Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel." Polymers 12, no. 11 (October 23, 2020): 2451. http://dx.doi.org/10.3390/polym12112451.
Abstract:
A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.
25
Chelu, Mariana, Adina Magdalena Musuc, Ludmila Aricov, Emma Adriana Ozon, Andreea Iosageanu, Laura M. Stefan, Ana-Maria Prelipcean, Monica Popa, and Jose Calderon Moreno. "Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications." International Journal of Molecular Sciences 24, no. 4 (February 15, 2023): 3893. http://dx.doi.org/10.3390/ijms24043893.
Abstract:
The present research aims to describe a new methodology to obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. The properties of two hydrogels (differing in Aloe vera concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the Aloe vera based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of Aloe vera based hydrogels was evaluated both on Gram-positive, Staphylococcus aureus and on Gram-negative, Pseudomonas aeruginosa strains. The obtained novel green Aloe vera based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this Aloe vera based hydrogel may be suitable for wound healing applications.
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Madivoli, Edwin Shigwenya, Justine Veronique Schwarte, Patrick Gachoki Kareru, Anthony Ngure Gachanja, and Katharina M. Fromm. "Stimuli-Responsive and Antibacterial Cellulose-Chitosan Hydrogels Containing Polydiacetylene Nanosheets." Polymers 15, no. 5 (February 21, 2023): 1062. http://dx.doi.org/10.3390/polym15051062.
Abstract:
Herein, we report a stimuli-responsive hydrogel with inhibitory activity against Escherichia coli prepared by chemical crosslinking of carboxymethyl chitosan (CMCs) and hydroxyethyl cellulose (HEC). The hydrogels were prepared by esterification of chitosan (Cs) with monochloroacetic acid to produce CMCs which were then chemically crosslinked to HEC using citric acid as the crosslinking agent. To impart a stimuli responsiveness property to the hydrogels, polydiacetylene-zinc oxide (PDA-ZnO) nanosheets were synthesized in situ during the crosslinking reaction followed by photopolymerization of the resultant composite. To achieve this, ZnO was anchored on carboxylic groups in 10,12-pentacosadiynoic acid (PCDA) layers to restrict the movement of the alkyl portion of PCDA during crosslinking CMCs and HEC hydrogels. This was followed by irradiating the composite with UV radiation to photopolymerize the PCDA to PDA within the hydrogel matrix so as to impart thermal and pH responsiveness to the hydrogel. From the results obtained, the prepared hydrogel had a pH-dependent swelling capacity as it absorbed more water in acidic media as compared to basic media. The incorporation of PDA-ZnO resulted in a thermochromic composite responsive to pH evidenced by a visible colour transition from pale purple to pale pink. Upon swelling, PDA-ZnO-CMCs-HEC hydrogels had significant inhibitory activity against E. coli attributed to the slow release of the ZnO nanoparticles as compared to CMCs-HEC hydrogels. In conclusion, the developed hydrogel was found to have stimuli-responsive properties and inhibitory activity against E. coli attributed to zinc nanoparticles.
27
Ciolacu, Diana Elena, Raluca Nicu, Dana Mihaela Suflet, Daniela Rusu, Raluca Nicoleta Darie-Nita, Natalia Simionescu, Georgeta Cazacu, and Florin Ciolacu. "Multifunctional Hydrogels Based on Cellulose and Modified Lignin for Advanced Wounds Management." Pharmaceutics 15, no. 11 (November 4, 2023): 2588. http://dx.doi.org/10.3390/pharmaceutics15112588.
Abstract:
Considering the complex process of wound healing, it is expected that an optimal wound dressing should be able to overcome the multiple obstacles that can be encountered in the wound healing process. An ideal dressing should be biocompatible, biodegradable and able to maintain moisture, as well as allow the removal of exudate, have antibacterial properties, protect the wound from pathogens and promote wound healing. Starting from this desideratum, we intended to design a multifunctional hydrogel that would present good biocompatibility, the ability to provide a favorable environment for wound healing, antibacterial properties, and also, the capacity to release drugs in a controlled manner. In the preparation of hydrogels, two natural polymers were used, cellulose (C) and chemically modified lignin (LE), which were chemically cross-linked in the presence of epichlorohydrin. The structural and morphological characterization of CLE hydrogels was performed by ATR-FTIR spectroscopy and scanning electron microscopy (SEM), respectively. In addition, the degree of swelling of CLE hydrogels, the incorporation/release kinetics of procaine hydrochloride (PrHy), and their cytotoxicity and antibacterial properties were investigated. The rheological characterization, mechanical properties and mucoadhesion assessment completed the study of CLE hydrogels. The obtained results show that CLE hydrogels have an increased degree of swelling compared to cellulose-based hydrogel, a better capacity to encapsulate PrHy and to control the release of the drug, as well as antibacterial properties and improved mucoadhesion. All these characteristics highlight that the addition of LE to the cellulose matrix has a positive impact on the properties of CLE hydrogels, confirming that these hydrogels can be considered as potential candidates for applications as oral wound dressings.
28
Thirupathi, Kokila, Chaitany Jayaprakash Raorane, Vanaraj Ramkumar, Selvakumari Ulagesan, Madhappan Santhamoorthy, Vinit Raj, Gopal Shankar Krishnakumar, Thi Tuong Vy Phan, and Seong-Cheol Kim. "Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications." Gels 9, no. 1 (December 30, 2022): 35. http://dx.doi.org/10.3390/gels9010035.
Abstract:
Chitosan is a prominent biopolymer in research for of its physicochemical properties and uses. Each year, the number of publications based on chitosan and its derivatives increases. Because of its comprehensive biological properties, including antibacterial, antioxidant, and tissue regeneration activities, chitosan and its derivatives can be used to prevent and treat soft tissue diseases. Furthermore, chitosan can be employed as a nanocarrier for therapeutic drug delivery. In this review, we will first discuss chitosan and chitosan-based hydrogel polymers. The structure, functionality, and physicochemical characteristics of chitosan-based hydrogels are addressed. Second, a variety of characterization approaches were used to analyze and validate the physicochemical characteristics of chitosan-based hydrogel materials. Finally, we discuss the antibacterial, antibiofilm, and antifungal uses of supramolecular chitosan-based hydrogels. This review study can be used as a base for future research into the production of various types of chitosan-based hydrogels in the antibacterial and antifungal fields.
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Fang, Xiuling, Cheng Wang, Shuwen Zhou, Pengfei Cui, Huaanzi Hu, Xinye Ni, Pengju Jiang, and Jianhao Wang. "Hydrogels for Antitumor and Antibacterial Therapy." Gels 8, no. 5 (May 19, 2022): 315. http://dx.doi.org/10.3390/gels8050315.
Abstract:
As a highly absorbent and hydrophobic material with a three-dimensional network structure, hydrogels are widely used in biomedical fields for their excellent biocompatibility, low immunogenicity, adjustable physicochemical properties, ability to encapsulate a variety of drugs, controllability, and degradability. Hydrogels can be used not only for wound dressings and tissue repair, but also as drug carriers for the treatment of tumors. As multifunctional hydrogels are the focus for many researchers, this review focuses on hydrogels for antitumor therapy, hydrogels for antibacterial therapy, and hydrogels for co-use in tumor therapy and bacterial infection. We highlighted the advantages and representative applications of hydrogels in these fields and also outlined the shortages and future orientations of this useful tool, which might give inspirations for future studies.
30
Wang, Zhijun, Lili Fu, Dongliang Liu, Dongxu Tang, Kun Liu, Lu Rao, Jinyu Yang, et al. "Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels." Gels 9, no. 7 (July 13, 2023): 571. http://dx.doi.org/10.3390/gels9070571.
Abstract:
Hydrogels are materials consisting of a network of hydrophilic polymers. Due to their good biocompatibility and hydrophilicity, they are widely used in biomedicine, food safety, environmental protection, agriculture, and other fields. This paper summarizes the typical complex materials of photocatalysts, photosensitizers, and hydrogels, as week as their antibacterial activities and the basic mechanisms of photothermal and photodynamic effects. In addition, the application of hydrogel-based photoresponsive materials in microbial inactivation is discussed, including the challenges faced in their application. The advantages of photosensitive antibacterial complex hydrogels are highlighted, and their application and research progress in various fields are introduced in detail.
31
Chen, Tai-Yu, Shih-Fu Ou, and Hsiu-Wen Chien. "Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels." Polymers 13, no. 11 (May 22, 2021): 1697. http://dx.doi.org/10.3390/polym13111697.
Abstract:
This study developed a tannic acid (TA)-supplemented 2-hydroxyethyl methacrylate-co-sulfobetaine methacrylate (HEMA-co-SBMA) nanocomposite hydrogel with mineralization and antibacterial functions. Initially, hybrid hydrogels were synthesized by incorporating SBMA into the HEMA network and the influence of SBMA on the chemical structure, water content, mechanical properties, and antibacterial characteristics of the hybrid HEMA/SBMA hydrogels was examined. Then, nanoclay (Laponite XLG) was introduced into the hybrid HEMA/SBMA hydrogels and the effects evaluated of the nanoclay on the chemical structure, water content, and mechanical properties of these supplemented hydrogels. The 50/50 hybrid HEMA/SBMA hydrogel with 30 mg/mL nanoclay showed outstanding mechanical properties (3 MPa) and water content (60%) compared to pure polyHEMA hydrogels. TA then went on to be incorporated into these hybrid nanocomposite hydrogels and its effects investigated on biomimetic mineralization. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) showed that bone-like spheroidal precipitates with a Ca/P ratio of 1.67% were observed after 28 days within these mineralized hydrogels. These mineralized hydrogels demonstrated an almost 1.5-fold increase in compressive moduli compared to the hydrogels without mineralization. These multifunctional hydrogels display good mechanical and biomimetic properties and may have applications in bone regeneration therapies.
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Jumat, Mohamad Amin, Nor Syahiran Zahidin, Mohd Amirul Aizat Zaini, Nurul Afiqah Fadzil, Hadi Nur, and Syafiqah Saidin. "INCORPORATION OF ACALYPHA INDICA EXTRACT IN POLYVINYL ALCOHOL HYDROGELS: PHYSICO-CHEMICAL, ANTIBACTERIAL AND CELL COMPATIBILITY ANALYSES." Jurnal Teknologi 83, no. 2 (February 2, 2021): 57–65. http://dx.doi.org/10.11113/jurnalteknologi.v83.14763.
Abstract:
Acalypha indica (A. indica) possesses antibacterial properties and has capability to accelerate wound healing due to its active therapeutic compounds of flavonoid and alkaloid. The incorporation of A. indica extracts in polymer hydrogels is useful for wound treatment, despite the advancement in synthetic medicines and drugs. In this study, polyvinyl alcohol (PVA) hydrogels with different concentrations of A. indica extract (0.5, 1.0, 1.5 and 2.0 mg) were fabricated. The ATR-FTIR spectra testified the presence of A. indica in the hydrogels. More enormous spotted agglomerations were visualized on the higher concentrations of A. indica hydrogels. The A. indica hydrogels became less moisture, more hydrophobic and has low water uptake ability compared to the control hydrogel (without A. indica). The antibacterial activities of the hydrogels against Escherichia coli and Staphylococcus aureus were acted in a dose-dependent manner where higher inhibition zones and higher bacterial retardations were recorded on the hydrogels with higher concentrations of A. indica. The incorporation of A. indica (1.0 - 1.5 mg/mL) has also induced cell viability, cell migration, and proliferation of the human skin fibroblasts. Therefore, optimization of the A. indica hydrogels is crucial in accommodating the bi-functional properties of antibacterial and biocompatibility for wound treatment.
33
Chen, Chun-Cheng, Jie-Mao Wang, Yun-Ru Huang, Yi-Hsuan Yu, Tzong-Ming Wu, and Shinn-Jyh Ding. "Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications." Pharmaceutics 15, no. 4 (March 29, 2023): 1090. http://dx.doi.org/10.3390/pharmaceutics15041090.
Abstract:
The thermoresponsive drug-loaded hydrogels have attracted widespread interest in the field of medical applications due to their ease of delivery to structurally complex tissue defects. However, drug-resistant infections remain a challenge, which has prompted the development of new non-antibiotic hydrogels. To this end, we prepared chitosan-methacrylate (CTSMA)/gelatin (GEL) thermoresponsive hydrogels and added natural phenolic compounds, including tannic acid, gallic acid, and pyrogallol, to improve the efficacy of hydrogels. This hybrid hydrogel imparted initial crosslinking at physiological temperature, followed by photocuring to further provide a mechanically robust structure. Rheological analysis, tensile strength, antibacterial activity against E. coli, S. aureus, P. gingivalis, and S. mutans, and L929 cytotoxicity were evaluated. The experimental results showed that the hybrid hydrogel with CTSMA/GEL ratio of 5/1 and tannic acid additive had a promising gelation temperature of about 37 °C. The presence of phenolic compounds not only significantly (p < 0.05) enhanced cell viability, but also increased the tensile strength of CTSMA/GEL hybrid hydrogels. Moreover, the hydrogel containing tannic acid revealed potent antibacterial efficacy against four microorganisms. It was concluded that the hybrid hydrogel containing tannic acid could be a potential composite material for medical applications.
34
Bao, Yunhui, Jian He, Ke Song, Jie Guo, Xianwu Zhou, and Shima Liu. "Functionalization and Antibacterial Applications of Cellulose-Based Composite Hydrogels." Polymers 14, no. 4 (February 16, 2022): 769. http://dx.doi.org/10.3390/polym14040769.
Abstract:
Pathogens, especially drug-resistant pathogens caused by the abuse of antibiotics, have become a major threat to human health and public health safety. The exploitation and application of new antibacterial agents is extremely urgent. As a natural biopolymer, cellulose has recently attracted much attention due to its excellent hydrophilicity, economy, biocompatibility, and biodegradability. In particular, the preparation of cellulose-based hydrogels with excellent structure and properties from cellulose and its derivatives has received increasing attention thanks to the existence of abundant hydrophilic functional groups (such as hydroxyl, carboxy, and aldehyde groups) within cellulose and its derivatives. The cellulose-based hydrogels have broad application prospects in antibacterial-related biomedical fields. The latest advances of preparation and antibacterial application of cellulose-based hydrogels has been reviewed, with a focus on the antibacterial applications of composite hydrogels formed from cellulose and metal nanoparticles; metal oxide nanoparticles; antibiotics; polymers; and plant extracts. In addition, the antibacterial mechanism and antibacterial characteristics of different cellulose-based antibacterial hydrogels were also summarized. Furthermore, the prospects and challenges of cellulose-based antibacterial hydrogels in biomedical applications were also discussed.
35
Micic, Maja, Simonida Tomic, Jovanka Filipovic, and Edin Suljovrujic. "Silver(I)-complexes with an itaconic acid-based hydrogel." Chemical Industry 63, no. 3 (2009): 137–42. http://dx.doi.org/10.2298/hemind0903137m.
Abstract:
Silver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)- -P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pure P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA- -based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.
36
Shahi, Sina, Mohammad J. Zohuriaan-Mehr, and Hossein Omidian. "Antibacterial superabsorbing hydrogels with high saline-swelling properties without gel blockage: Toward ideal superabsorbents for hygienic applications." Journal of Bioactive and Compatible Polymers 32, no. 2 (July 27, 2016): 128–45. http://dx.doi.org/10.1177/0883911516658782.
Abstract:
Superabsorbent polymer hydrogels with antibacterial activity were prepared by an ion exchange reaction as a feasible approach to induce high saline absorption without gel blockage. Hydroethanolic solutions of cetyltrimethylammonium bromide were used to modify surface particles of cross-linked sodium acrylate- co-acrylic acid copolymers which already synthesized under defined conditions. Fourier transform infrared spectroscopy was employed to study the structural characteristic of the finished products. The influence of cetyltrimethylammonium bromide on free (in water) and loaded (in saline) swelling capacity as well as antibacterial activity of superabsorbent polymer hydrogels against Staphylococcus aureus was investigated. Modified samples displayed an improved free and loaded swelling in water and saline, as well as no gel-blocking. These improvements were found to be affected by the reaction time, cetyltrimethylammonium bromide concentration, and water percentage in the solvent mixture. The results from energy dispersive X-ray analysis showed that cetyltrimethylammonium bromide was distributed uniformly in the superabsorbent polymer hydrogel particle surface. Moreover, the modified superabsorbent polymer hydrogels showed high antibacterial activity against S. aureus. Both bacteriostatic and bactericide effects were observed depending on the reaction conditions. Overall, several improvements were concurrently achieved via a single cost-effective post-treatment on the superabsorbent polymer hydrogel particles. Therefore, the results can effectively be used in designing larger scale production of antibacterial superabsorbent polymer hydrogels with desirable swelling properties in hygiene applications.
37
Rao, Kummara Madhusudana, Uluvangada Thammaiah Uthappa, Hyeon Jin Kim, and Sung Soo Han. "Tissue Adhesive, Biocompatible, Antioxidant, and Antibacterial Hydrogels Based on Tannic Acid and Fungal-Derived Carboxymethyl Chitosan for Wound-Dressing Applications." Gels 9, no. 5 (April 22, 2023): 354. http://dx.doi.org/10.3390/gels9050354.
Abstract:
This study aimed to develop hydrogels for tissue adhesion that are biocompatible, antioxidant, and antibacterial. We achieved this by using tannic acid (TA) and fungal-derived carboxymethyl chitosan (FCMCS) incorporated in a polyacrylamide (PAM) network using free-radical polymerization. The concentration of TA greatly influenced the physicochemical and biological properties of the hydrogels. Scanning electron microscopy showed that the nanoporous structure of the FCMCS hydrogel was retained with the addition of TA, resulting in a nanoporous surface structure. Equilibrium-swelling experiments revealed that increasing the concentration of TA significantly improved water uptake capacity. Antioxidant radical-scavenging assays and porcine skin adhesion tests confirmed the excellent adhesive properties of the hydrogels, with adhesion strengths of up to 39.8 ± 1.2 kPa for 1.0TA-FCMCS due to the presence of abundant phenolic groups on TA. The hydrogels were also found to be biocompatible with skin fibroblast cells. Furthermore, the presence of TA significantly enhanced the antibacterial properties of the hydrogels against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Therefore, the developed drug-free antibacterial and tissue-adhesive hydrogels can potentially be used as wound dressings for infected wounds.
38
Parın, Fatma Nur. "SYNTHESIS OF ANTIBACTERIAL PVA-AAM PICKERING EMULSION HYDROGELS (PEHs) FOR MEDICAL APPLICATIONS." Mühendislik Bilimleri ve Tasarım Dergisi 12, no. 2 (June 30, 2024): 384–91. http://dx.doi.org/10.21923/jesd.1234473.
Abstract:
Citronella essential oil (CEO) has antibacterial characteristics that can be used in medical applications. Polyvinyl alcohol/acrylamide (PVA/AAm) hydrogels including CEO were stabilized utilizing beta-cyclodextrin (β-CD) carbonhydrate-based material. In this context, PVA polymer, and AAm monomer were used as matrix (water phase) whereas CEO and (oil phase) and carbohydrate-based β-cyclodextrin (β-CD) were used in the emulsion system as an active agent and an emulsifier, respectively. The β-CD/CEO inclusion complexes were introduced to PVA/AAm hydrogels in different ratios (1:0.25, 1:0.5, and 1:1% w/v), and to obtain Pickering hydrogels by combining UV and freeze-thawing and anneal-swelling methods, respectively. The influence of different β-CD/CEO ratios on the morphological, physical, hydrophilicity and antibacterial efficiency of PVA/AAm was studied, as well. Although the amount of CEO increased, the hydrophilicity of hydrogels increased, while the swelling properties of hydrogels decreased. Moreover, the hydrogel with the highest amount of CEO showed the highest value of antibacterial activity against both Escherichia coli and Staphylococcus aureus bacteria. The resulting Pickering hydrogels (PEHs) can be a potential use as tissue expander for many medical field.
39
Carreño, Gustavo, Adolfo Marican, Sekar Vijayakumar, Oscar Valdés, Gustavo Cabrera-Barjas, Johanna Castaño, and Esteban F. Durán-Lara. "Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths." Pharmaceutics 12, no. 10 (October 17, 2020): 982. http://dx.doi.org/10.3390/pharmaceutics12100982.
Abstract:
A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.
40
Yahya, Esam, and Muhanad Abdullah Abdulsamad. "In-vitro Antibacterial Activity of Carbopol-Essential Oils hydrogels." Journal of Applied Science & Process Engineering 7, no. 2 (October 30, 2020): 564–71. http://dx.doi.org/10.33736/jaspe.2547.2020.
Abstract:
Background and Objectives: The main purpose of the drug therapy of any disease is to maintain the desired therapeutic concen-tration of the drug for the entire duration of the treatment. The aim of this study is to formulate mixed essential oils loaded hydrogel, and evaluate its antibacterial activity against some pathogens. Materials and Methods: Different hydrogels were formulated by using different concentration of essential oils. Antibacterial evaluation was done using disk diffusion method. Screening for antibacterial activity of essential oils were studied prior to hydrogel formulation to compare the changes in activity after incorporation in the hydrogel. Results: Clove oil exhibited the strongest activity towards all the tested pathogens, compared to other tested essential oils (clove > cinnamon > tea tree > rosemary). The formulation containing mixed essential oils showed the best results, with synergistic effect against all tested pathogens. Hydrogels were further subjected to evaluation of physical properties like color, clarity, pH, viscosity and animal skin irritation study. The zone of inhibition of the final formulation containing only 3% from the selected three essential oils was between 18‐23 mm for S. aureus, 17‐20mm for E. coli, and 14‐18mm for P. aeruginosa. The hydrogels were non-irritant, stable, and free of any microbes at room temperature. Conclusion: Activity of essential oils was much affected by incorporation in hydrogel. The loaded hydrogel showed better antimicrobial activity against all the microorganisms used in the study, despite the need for clinical studies to determine of the effectiveness and potential toxic effects in-vivo.
41
Cao, Mengjiao, Chengcheng Liu, Mengxin Li, Xu Zhang, Li Peng, Lijia Liu, Jinfeng Liao, and Jing Yang. "Recent Research on Hybrid Hydrogels for Infection Treatment and Bone Repair." Gels 8, no. 5 (May 16, 2022): 306. http://dx.doi.org/10.3390/gels8050306.
Abstract:
The repair of infected bone defects (IBDs) is still a great challenge in clinic. A successful treatment for IBDs should simultaneously resolve both infection control and bone defect repair. Hydrogels are water-swollen hydrophilic materials that maintain a distinct three-dimensional structure, helping load various antibacterial drugs and biomolecules. Hybrid hydrogels may potentially possess antibacterial ability and osteogenic activity. This review summarizes the recent progress of different kinds of antibacterial agents (including inorganic, organic, and natural) encapsulated in hydrogels. Several representative hydrogels of each category and their antibacterial mechanism and effect on bone repair are presented. Moreover, the advantages and disadvantages of antibacterial agent hybrid hydrogels are discussed. The challenge and future research directions are further prospected.
42
Yuan, Xiangnan, Jun Zhang, Jiayin Shi, Wenfu Liu, Andreii S. Kritchenkov, Sandra Van Vlierberghe, Lu Wang, Wanjun Liu, and Jing Gao. "Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties." Polymers 16, no. 10 (May 9, 2024): 1346. http://dx.doi.org/10.3390/polym16101346.
Abstract:
Antibacterial hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process. However, it remains a challenge to fabricate hydrogel wound dressings that simultaneously exhibit excellent mechanical and photothermal antibacterial properties. Here we report the development of polydopamine-functionalized graphene oxide (rGO@PDA)/calcium alginate (CA)/Polypyrrole (PPy) cotton fabric-reinforced hydrogels (abbreviated as rGO@PDA/CA/PPy FHs) for tackling bacterial infections. The mechanical properties of hydrogels were greatly enhanced by cotton fabric reinforcement and an interpenetrating structure, while excellent broad-spectrum photothermal antibacterial properties based on the photothermal effect were obtained by incorporating PPy and rGO@PDA. Results indicated that rGO@PDA/CA/PPy FHs exhibited superior tensile strength in both the warp (289 ± 62.1 N) and weft directions (142 ± 23.0 N), similarly to cotton fabric. By incorporating PPy and rGO@PDA, the swelling ratio was significantly decreased from 673.5% to 236.6%, while photothermal conversion performance was significantly enhanced with a temperature elevated to 45.0 °C. Due to the synergistic photothermal properties of rGO@PDA and PPy, rGO@PDA/CA/PPy FHs exhibited excellent bacteria-eliminating efficiency for S. aureus (0.57%) and E. coli (3.58%) after exposure to NIR for 20 min. We believe that the design of fabric-reinforced hydrogels could serve as a guideline for developing hydrogel wound dressings with improved mechanical properties and broad-spectrum photothermal antibacterial properties for infected-wound treatment.
43
Zhao, Che, Chengju Sheng, and Chao Zhou. "Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels." Gels 8, no. 1 (January 12, 2022): 52. http://dx.doi.org/10.3390/gels8010052.
Abstract:
Traditional antibacterial hydrogels have a broad-spectrum bactericidal effect and are widely used as wound dressings. However, the biological toxicity and drug resistance of these antibacterial hydrogels cannot meet the requirements of long-term clinical application. Imidazolium poly(ionic liquids) (PILs) are polymeric antibacterial agents exhibiting strong antibacterial properties, as they contain a strong positive charge. In this study, two imidazolium PILs, namely poly(N-butylimidazolium propiolic acid sodium) (PBP) and poly(N-(3,6-dioxaoctane) imidazolium propiolic acid sodium) (PDP), as high efficiency antibacterial agents, were synthesized by polycondensation reaction. Then, the PILs were compounded with polyethylene glycol (PEG) by a thiol-yne click reaction to prepare injectable antibacterial hydrogels. An in vitro assay showed that the injectable antibacterial hydrogels could not only quickly kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), but also had low toxicity for human skin fibroblasts cells (HSFs) and human umbilical vein endothelial cells (HUVECs), respectively. Additionally, the lipopolysaccharide (LPS) inflammation model revealed that the injectable antibacterial hydrogels also had anti-inflammatory effects, which would be advantageous to accelerate wound healing.
44
Sheng, Chengju, Xuemei Tan, Qing Huang, Kewen Li, Chao Zhou, and Mingming Guo. "Antibacterial and Angiogenic Poly(Ionic Liquid) Hydrogels." Gels 8, no. 8 (July 28, 2022): 476. http://dx.doi.org/10.3390/gels8080476.
Abstract:
Wounds, particularly under low-hydration conditions, require more time to repair successfully. Therefore, there is an urgent need to develop wound dressings that can accelerate wound healing. Hydrogels, which can maintain a moist environment around the wound and allow gas to pass through the material, act as antibacterial hydrogels as dressings and have great application value in the treatment of wounds. In addition, wound dressings (hydrogels) containing antibacterial capacity have lasting antibacterial effects and reduce damage to cells. In this work, we firstly synthesized two antibacterial agents: imidazolium poly(ionic liquids) containing sulfhydryl (Imidazole-SH) and ε-Poly(lysine) containing SH (EPL-SH). Then, lysine as a cross-linking agent, by “thiol-ene” click reaction, was mixed with Deferoxamine (DFO) to prepare the antibacterial hydrogels. The in vitro assays showed that the hydrogels could effectively kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In addition, it also could reduce the inflammatory response produced by Lipopolysaccharide (LPS). More importantly, according to the transwell and angiogenesis assays, DFO-incorporated hydrogels promoted the migration and vascular repair of human umbilical vein endothelial cells (HUVECs). All the results revealed that the hydrogels provided new strategies for wound dressings.
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Fathil, Mohammad Aqil M., and Haliza Katas. "Antibacterial, Anti-Biofilm and Pro-Migratory Effects of Double Layered Hydrogels Packaged with Lactoferrin-DsiRNA-Silver Nanoparticles for Chronic Wound Therapy." Pharmaceutics 15, no. 3 (March 19, 2023): 991. http://dx.doi.org/10.3390/pharmaceutics15030991.
Abstract:
Antimicrobial resistance and biofilm formation in diabetic foot infections worsened during the COVID-19 pandemic, resulting in more severe infections and increased amputations. Therefore, this study aimed to develop a dressing that could effectively aid in the wound healing process and prevent bacterial infections by exerting both antibacterial and anti-biofilm effects. Silver nanoparticles (AgNPs) and lactoferrin (LTF) have been investigated as alternative antimicrobial and anti-biofilm agents, respectively, while dicer-substrate short interfering RNA (DsiRNA) has also been studied for its wound healing effect in diabetic wounds. In this study, AgNPs were complexed with LTF and DsiRNA via simple complexation before packaging in gelatin hydrogels. The formed hydrogels exhibited 1668% maximum swellability, with a 46.67 ± 10.33 µm average pore size. The hydrogels demonstrated positive antibacterial and anti-biofilm effects toward the selected Gram-positive and Gram-negative bacteria. The hydrogel containing AgLTF at 125 µg/mL was also non-cytotoxic on HaCaT cells for up to 72 h of incubation. The hydrogels containing DsiRNA and LTF demonstrated superior pro-migratory effects compared to the control group. In conclusion, the AgLTF-DsiRNA-loaded hydrogel possessed antibacterial, anti-biofilm, and pro-migratory activities. These findings provide a further understanding and knowledge on forming multipronged AgNPs consisting of DsiRNA and LTF for chronic wound therapy.
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Fullenkamp, Dominic E., José G. Rivera, Yong-kuan Gong, K. H. Aaron Lau, Lihong He, Rahul Varshney, and Phillip B. Messersmith. "Mussel-inspired silver-releasing antibacterial hydrogels." Biomaterials 33, no. 15 (May 2012): 3783–91. http://dx.doi.org/10.1016/j.biomaterials.2012.02.027.
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Nepomuceno, Fábio Gondim, Geceane Dias, Pascally Maria Aparecida Guerra de Araujo, Líbia de Souza Conrado Oliveira, Marcus Vinícius Lia Fook, and Ana Cristina Figueiredo de Melo Costa. "Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses." Research, Society and Development 11, no. 3 (March 7, 2022): e25911326646. http://dx.doi.org/10.33448/rsd-v11i3.26646.
Abstract:
Chitosan hydrogels stand out for being an adhesive matrix, which presents biocompatibility, antibacterial and osteogenic properties, biodegradability, non-toxicity, capable of retaining, releasing, and distributing therapeutic agents (drugs) at the application site. Therefore, new strategies in the field of orthopedics have focused, above all, on limiting the initial preoperative and postoperative microbial adhesion to implant surfaces, modifying these surfaces, protecting them from eventual adhesions or releasing the antimicrobial agent. The production of chitosan-based hydrogels has been achieved through physical and chemical cross-linking routes. In this context, this research aimed to develop an antibacterial hydrogel based on chitosan and vancomycin for application in total knee arthroplasty and to prevent bacterial infections. For that, three crosslinking procedures of chitosan with genipin were investigated to obtain the hydrogels and drug delivery. For this purpose, initially, the raw materials chitosan, genipin and vancomycin were characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), pHmetry (pH) and microbiological tests. From the chemical crosslinking procedures evaluated, the drug release was investigated, and the hydrogels were characterized by FTIR, pH, viscosity, microbiology, and cytotoxicity. A new H5Q1GV hydrogel was obtained with good antibacterial activity, potentiated by the acidity of its pH 5.7, which showed good drug release in the first 4 hours after implantation, homogeneous, with ideal viscosity and adhesion for application through syringes in prosthesis surgery. knee and with excellent biocompatibility.
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Singh, Vandana, Devika Srivastava, Prashant Pandey, Mukesh Kumar, Sachin Yadav, Dinesh Kumar, and R. Venkatesh Kumar. "Characterization, antibacterial and anticancer study of silk fibroin hydrogel." Journal of Drug Delivery and Therapeutics 13, no. 2 (February 15, 2023): 21–31. http://dx.doi.org/10.22270/jddt.v13i2.5733.
Abstract:
Purpose: Protein-based hydrogels such as silk fibroin hydrogel, are used in tissue engineering and regenerative medicine applications as they showed striking characteristics like biocompatibility and offered various benefits as biomaterials. The current study sought to prepare silk fibroin hydrogel and characterise it in order to assess its antibacterial and anticancer activity.
Methodology: Silk fibroin hydrogel was prepared and characterized by using different microscopy methods, namely Scanning Electron Microscopy (SEM), Phase Contrast Electron (PCM) microscopy, and foldscope analysis. Further, it was characterized through 1H-NMR analysis, Fourier Transform Infrared spectroscopy (FTIR) analysis, and swelling properties. A Current study also covers an antimicrobial and anticancer analysis of silk fibroin hydrogel by disk diffusion method and SRB (Sulforhodamine B) assay respectively.
Results: The antibacterial study confirmed that SF hydrogel has a moderate antibacterial activity for Streptococcus mutans, and Salmonella typhi. Additionally, the SRB assay test showed that silk fibroin hydrogels had moderate anticancer activity against the human lung cancer cell line (A549).
Conclusion: The current study unequivocally demonstrates that silk fibroin hydrogel has antibacterial and anti-cancerous properties, making it a suitable scaffold for future studies that seek to target a specific drug delivery site.
Keywords: Silk fibroin; Swelling behaviour; Anticancer; Drug carrier; Wound healing
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Han, Xiaoman, Guihua Meng, Qian Wang, Lin Cui, Hao Wang, Jianning Wu, Zhiyong Liu, and Xuhong Guo. "Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing." Journal of Biomaterials Applications 33, no. 7 (November 22, 2018): 915–23. http://dx.doi.org/10.1177/0885328218810552.
Abstract:
All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel. The two hydrogels are prepared by applying an enzyme-catalyzed crosslinking means in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structures were characterized through 1H-NMR and FT-IR. In conclusion, both PBS-PD and CSE-PD hydrogels exhibit superior tissue adhesion properties, and remarkable anti-infection quality. In addition, these two hydrogels manifest prominent hemostatic efficiency. The bio adhesion performance can achieve 30 kPa, meanwhile the CSE-PD hydrogels show good germicidal properties, and the antibacterial rate can reach 98%. The hydrogels could reduce blood loss without any obvious side effect, and present a new prospect in the field of hemostasis rapidly.
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Tavares, Lucas, Minchan Shim, Ruchi Patil Borole, Vijay Mohakar, Anton Sorkin, and Vladimir Reukov. "NANOCERIA INFUSED CHITOSAN-PVA HYDROGELS TO TREAT BURN WOUNDS." Biomedical Sciences Instrumentation 58, no. 3 (July 15, 2022): 208–12. http://dx.doi.org/10.34107/lwwj5713208.
Abstract:
Burn wounds are highly dangerous injuries with significant mortality rates. They are painful and increase the risk of bacterial infection. Burn wounds could also harm adjacent tissues by releasing dangerous compounds. Thus, their treatment should work quickly and effectively. Hydrogels are used as burn wound dressings that provide a suitable environment for regeneration. They closely imitate the structure of the skin’s extracellular matrix and have high water uptake properties, providing a moist environment for faster healing. Chitosan-PVA based hydrogels demonstrated antibacterial and healing effects on wounds. Nanoparticles of cerium oxide called nanoceria were shown to reduce local oxidative stress by decomposing reactive oxygen species. The goal of this study is to learn the effects of nanoceria infused chitosan-PVA hydrogels on wound regeneration. We characterized hydrogels with various chitosan-PVA ratios, crosslinked with tetraethyl orthosilicate. These trials improved the procedure for making hydrogels capable of maintaining a moist environment for better wound healing. Further experiments demonstrated the biocompatibility and antibacterial properties of the hydrogels crosslinked with glutaraldehyde, where 3T3 fibroblasts seeded on the hydrogels were shown to be viable and zone of inhibition tests performed with E. coli demonstrated the antibacterial capacity of the hydrogels. Future studies will determine the antioxidant capacity and further bioactive properties of the nanoceria infused hydrogel. Once the small-scale procedure is well established the proposed methods could be implemented in clinical applications to aid in burn wound recovery.