Relevant bibliographies by topics / Antibacterial hydrogels

Academic literature on the topic 'Antibacterial hydrogels'

Author: Grafiati
Published: 7 July 2024
Last updated: 7 July 2024

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Journal articles on the topic "Antibacterial hydrogels":

1

Li, Shuqiang, Shujun Dong, Weiguo Xu, Shicheng Tu, Lesan Yan, Changwen Zhao, Jianxun Ding, and Xuesi Chen. "Antibacterial Hydrogels." Advanced Science 5, no. 5 (February 22, 2018): 1700527. http://dx.doi.org/10.1002/advs.201700527.

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2

Peng, Tai, Qi Shi, Manlong Chen, Wenyi Yu, and Tingting Yang. "Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review." Journal of Functional Biomaterials 14, no. 5 (April 25, 2023): 243. http://dx.doi.org/10.3390/jfb14050243.

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Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.
3

Rao, Kummara Madhusudana, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi, and Sung Soo Han. "Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels." Pharmaceutics 14, no. 5 (May 10, 2022): 1028. http://dx.doi.org/10.3390/pharmaceutics14051028.

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In this work, fungal mushroom-derived carboxymethyl chitosan-polydopamine hydrogels (FCMCS-PDA) with multifunctionality (tissue adhesive, hemostasis, self-healing, and antibacterial properties) were developed for wound dressing applications. The hydrogel is obtained through dynamic Schiff base cross-linking and hydrogen bonds between FCMCS-PDA and covalently cross-linked polyacrylamide (PAM) networks. The FCMCS-PDA-PAM hydrogels have a good swelling ratio, biodegradable properties, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were formed along with FCMCS fibers in the hydrogel networks, which has a high impact on the biological performance of hydrogels. The maximum adhesion strength of the hydrogel to porcine skin was achieved at about 29.6 ± 2.9 kPa. The hydrogel had good self-healing and recoverable properties. The PDA-containing hydrogels show good antibacterial properties on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. Moreover, the adhesive hydrogels depicted good viability and attachment of skin fibroblasts and keratinocyte cells. Importantly, FCMCS and PDA combined resulted in fast blood coagulation within 60 s. Hence, the adhesive hydrogel with multifunctionality has excellent potential as a wound dressing material for infected wounds.
4

He, Weizhong, Yajuan Zhu, Yan Chen, Qi Shen, Zhenyu Hua, Xian Wang, and Peng Xue. "Inhibitory Effect and Mechanism of Chitosan–Ag Complex Hydrogel on Fungal Disease in Grape." Molecules 27, no. 5 (March 4, 2022): 1688. http://dx.doi.org/10.3390/molecules27051688.

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Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface. The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields. However, there have been few reports on its application for controlling postharvest diseases in fruit. In this study, the Chitosan–silver (CS–Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape. The prepared hydrogels were stable for a long period at room temperature. The structure and surface morphology of CS–Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD. The inhibitory effects of CS–Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro. The remarkable antibacterial activity of CS–Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag. Preservation tests showed that the CS–Ag hydrogel had positive fresh-keeping effect. This revealed that CS–Ag hydrogels can play a critical role in controlling fungal disease in grapes.
5

Wei, Lai, Jianying Tan, Li Li, Huanran Wang, Sainan Liu, Junying Chen, Yajun Weng, and Tao Liu. "Chitosan/Alginate Hydrogel Dressing Loaded FGF/VE-Cadherin to Accelerate Full-Thickness Skin Regeneration and More Normal Skin Repairs." International Journal of Molecular Sciences 23, no. 3 (January 23, 2022): 1249. http://dx.doi.org/10.3390/ijms23031249.

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The process of full-thickness skin regeneration is complex and has many parameters involved, which makes it difficult to use a single dressing to meet the various requirements of the complete regeneration at the same time. Therefore, developing hydrogel dressings with multifunction, including tunable rheological properties and aperture, hemostatic, antibacterial and super cytocompatibility, is a desirable candidate in wound healing. In this study, a series of complex hydrogels were developed via the hydrogen bond and covalent bond between chitosan (CS) and alginate (SA). These hydrogels exhibited suitable pore size and tunable rheological properties for cell adhesion. Chitosan endowed hemostatic, antibacterial properties and great cytocompatibility and thus solved two primary problems in the early stage of the wound healing process. Moreover, the sustained cytocompatibility of the hydrogels was further investigated after adding FGF and VE-cadherin via the co-culture of L929 and EC for 12 days. The confocal 3D fluorescent images showed that the cells were spherical and tended to form multicellular spheroids, which distributed in about 40–60 μm thick hydrogels. Furthermore, the hydrogel dressings significantly accelerate defected skin turn to normal skin with proper epithelial thickness and new blood vessels and hair follicles through the histological analysis of in vivo wound healing. The findings mentioned above demonstrated that the CS/SA hydrogels with growth factors have great potential as multifunctional hydrogel dressings for full-thickness skin regeneration incorporated with hemostatic, antibacterial, sustained cytocompatibility for 3D cell culture and normal skin repairing.
6

Xu, Weiguo, Shujun Dong, Yuping Han, Shuqiang Li, and Yang Liu. "Hydrogels as Antibacterial Biomaterials." Current Pharmaceutical Design 24, no. 8 (May 14, 2018): 843–54. http://dx.doi.org/10.2174/1381612824666180213122953.

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Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.
7

Chen, Zhuoyue, Min Mo, Fanfan Fu, Luoran Shang, Huan Wang, Cihui Liu, and Yuanjin Zhao. "Antibacterial Structural Color Hydrogels." ACS Applied Materials & Interfaces 9, no. 44 (October 24, 2017): 38901–7. http://dx.doi.org/10.1021/acsami.7b11258.

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Sun, Ying, Jiayi Wang, Duanxin Li, and Feng Cheng. "The Recent Progress of the Cellulose-Based Antibacterial Hydrogel." Gels 10, no. 2 (January 29, 2024): 109. http://dx.doi.org/10.3390/gels10020109.

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Cellulose-based antibacterial hydrogel has good biocompatibility, antibacterial performance, biodegradability, and other characteristics. It can be very compatible with human tissues and degradation, while its good water absorption and moisturizing properties can effectively absorb wound exudates, keep the wound moist, and promote wound healing. In this paper, the structural properties, and physical and chemical cross-linking preparation methods of cellulose-based antibacterial hydrogels were discussed in detail, and the application of cellulose-based hydrogels in the antibacterial field was deeply studied. In general, cellulose-based antibacterial hydrogels, as a new type of biomaterial, have shown good potential in antimicrobial properties and have been widely used. However, there are still some challenges, such as optimizing the preparation process and performance parameters, improving the antibacterial and physical properties, broadening the application range, and evaluating safety. However, with the deepening of research and technological progress, it is believed that cellulose-based antibacterial hydrogels will be applied and developed in more fields in the future.
9

Li, Rongkai, Qinbing Qi, Chunhua Wang, Guige Hou, and Chengbo Li. "Self-Healing Hydrogels Fabricated by Introducing Antibacterial Long-Chain Alkyl Quaternary Ammonium Salt into Marine-Derived Polysaccharides for Wound Healing." Polymers 15, no. 6 (March 15, 2023): 1467. http://dx.doi.org/10.3390/polym15061467.

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The development of hydrogels as wound dressings has gained considerable attention due to their promising ability to promote wound healing. However, in many cases of clinical relevance, repeated bacterial infection, which might obstruct wound healing, usually occurs due to the lack of antibacterial properties of these hydrogels. In this study, we fabricated a new class of self-healing hydrogel with enhanced antibacterial properties based on dodecyl quaternary ammonium salt (Q12)-modified carboxymethyl chitosan (Q12-CMC), aldehyde group- modified sodium alginate (ASA), Fe3+ via Schiff bases and coordination bonds (QAF hydrogels). The dynamic Schiff bases and coordination interactions conferred excellent self-healing abilities to the hydrogels, while the incorporation of dodecyl quaternary ammonium salt gave the hydrogels superior antibacterial properties. Additionally, the hydrogels displayed ideal hemocompatibility and cytocompatibility, crucial for wound healing. Our full-thickness skin wound studies demonstrated that QAF hydrogels could result in rapid wound healing with reduced inflammatory response, increased collagen disposition and improved vascularization. We anticipate that the proposed hydrogels, possessing both antibacterial and self-healing properties, will emerge as a highly desirable material for skin wound repair.
10

Yu, Jie, Fangli Ran, Chenyu Li, Zhenxin Hao, Haodong He, Lin Dai, Jingfeng Wang, and Wenjuan Yang. "A Lignin Silver Nanoparticles/Polyvinyl Alcohol/Sodium Alginate Hybrid Hydrogel with Potent Mechanical Properties and Antibacterial Activity." Gels 10, no. 4 (April 1, 2024): 240. http://dx.doi.org/10.3390/gels10040240.

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Antibacterial hydrogels have attracted significant attention due to their diverse applications, efficient antimicrobial properties, and adaptability to various environments and requirements. However, their relatively fragile structure, coupled with the potential for environmental toxicity when exposed to their surroundings for extended periods, may significantly limit their practical application potential. In this work, a composite hydrogel was synthesized with outstanding mechanical features and antibacterial capability. The hydrogel was developed through the combination of the eco-friendly and enduring antibacterial agent, lignin silver nanoparticles (Lig-Ag NPs), with polyvinyl alcohol (PVA) and sodium alginate (SA), in varying proportions. The successful synthesis of the hydrogel and the dispersed distribution of Lig-Ag NPs within the hydrogel were confirmed by various analytical techniques, including field emission scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), mercury intrusion porosimetry (MIP), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The formation of multiple hydrogen bonds between Lig-Ag NPs and the composites contributed to a more stable and dense network structure of the hydrogel, consequently enhancing its mechanical properties. Rheological tests revealed that the hydrogel exhibited an elastic response and demonstrated outstanding self-recovery properties. Significantly, the antibacterial hydrogel demonstrated effectiveness against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), achieving a <5% survival of bacteria within 12 h. This study presented a green and straightforward synthetic strategy for the application of antibacterial composite hydrogels in various fields.
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Journal articles Dissertations / Theses

Dissertations / Theses on the topic "Antibacterial hydrogels":

1

Kloxin, April Morris. "Synthesis and Characterization of Antibacterial Poly(ethylene glycol) Hydrogels." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-08152004-202806/.

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Poly(ethylene glycol) (PEG) hydrogels containing tertiary amines were synthesized by thermally-initiated free-radical copolymerization of poly(ethylene glycol) methacrylate (PEGMA), poly(ethylene glycol) dimethacrylate (PEGDMA), and 2-dimethylaminoethyl methacrylate (DMAEMA). The mass fraction of each monomer was varied from 0 to ~1 to determine the composition for optimum mechanical properties and maximum tertiary amine content. Dry films were characterized by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), elemental analysis, dynamical mechanical analysis (DMA), tensile testing, swelling, and differential scanning calorimetry (DSC). The film composition with highest strength, elasticity, swelling, and amine content was found to be 30 wt% PEGDMA due to limited polymerization of DMAEMA with PEGDMA. Films composed of 10 wt% PEGDMA were subsequently quaternized with alkyl bromides of varying chain length (C8, C12, and C16) to impart antibacterial properties to the network. Quaternized films were characterized by elemental analysis, swelling, DSC, and a surface antimicrobial assay. The minimum quaternized DMAEMA concentration for antimicrobial activity was 22 wt% quaternized with C8Br and 30 wt% quaternized with C12Br and C16Br. The most potent alkyl bromide was C8Br followed by C12Br and C16Br. These quaternized PEG-co-poly(DMAEMA) hydrogels show promise as antibacterial materials for biomedical applications.
2

Mobley, Emily B. "Antibacterial Coatings Derived from Novel Chemically Responsive Vesicles." DigitalCommons@CalPoly, 2020. https://digitalcommons.calpoly.edu/theses/2200.

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In order for a drug, or any material used for the purpose of eliciting a change in an organisms’ physical or chemical state, to be effective it must reach the intended target intact and for a sustained rate over time. Drug delivery systems encapsulate a drug to protect it from degradation, prevent side reactions, increase solubility, improve accumulation rates at target sites, and release drugs at a controlled rate. Controlled and sustained release of drugs is achieved by degradation of the carrier triggered by breaking dynamic chemical bonds caused by changes in the chemical environment such as pH or redox conditions. Slow, first order kinetic release of drugs increase therapeutic efficacy while also reducing side effects and other cytotoxicity issues. Up and coming drug delivery systems include hydrogels and nanocarriers such as vesicles. Hydrogel drug delivery systems are unique three-dimensional networks of crosslinked hydrophilic polymers that contain anywhere from 50-90 wt% of water. Drugs can be loaded via encapsulation during the gelation process or may be covalently bound to the polymer backbone before gelation. Amphiphilic molecules or polymers that self-assemble in aqueous solutions to form supramolecular nanostructures, such as vesicles, can encapsulate hydrophilic drugs in the aqueous interior or hydrophobic drugs in the lipophilic bilayer membrane. This study seeks to embed vesicles into a hydrogel to create a hybrid drug delivery system which may be applied as a coating to medical devices to prevent bacterial adhesion and growth, injected directly to a target site, or as an additive for wound dressings. This hybrid system mitigates burst release from the hydrogel, as well as stabilizes the vesicles to afford a longer shelf life. Vesicles are prepared from a novel supramolecular amphiphile composed of thio-alkyl modified��-cyclodextrin as a macrocyclic host, and an adamantyl-dithiopropionic acid modified poly(ethylene glycol) as a linear guest. This host-guest system forms inclusion complexes that self-assemble to bilayered vesicles, which may encapsulate a payload, in aqueous solutions. These vesicles serve as three-dimensional multivalent junctions to form a hydrogel, which may encapsulate a second payload, through a dynamic disulfide exchange crosslinking reaction. This novel drug delivery system will be capable of dual and selective release of two different encapsulated payloads. A pH sensitive acid labile bond embedded in the crosslinker will cleave under acidic conditions to release the payload enclosed in the hydrogel matrix, while a disulfide bond embedded in the supramolecular amphiphile of the free vesicle can be cleaved in the presence of naturally occurring antioxidant glutathione, GSH, to release the second payload. It has been discovered that vesicles efficaciously form, can encapsulate a payload, and are stable for several weeks, up to a month. Vesicle stability is examined in the presence of both intracellular and extracellular concentrations of GSH, and it is found that vesicles are more stable in extracellular concentrations of GSH. Crosslinking of vesicles is attempted at several molecular weights of linear thiol terminated poly(ethylene glycol) crosslinker, concentrations ratios of crosslinker: vesicle, pHs, and temperatures. It can be concluded that the crosslinking density with the linear crosslinker is not high enough to form a hydrogel. Future studies will include 4-arm crosslinkers which are predicted to increase the number of crosslinking points and hence the crosslinking density.
3

Loth, Capucine. "Exploring hydrogels based on the self-assembly of a Fmoc-based tripeptide : physicochemical characterization and antibacterial properties." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAE002.

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Les hydrogels sont des réseaux 3D retenant de grandes quantités d'eau. Biocompatibles, ils sont utilisés pour la délivrance de médicaments. Dans le but de développer des hydrogels antibactériens, cette thèse présente deux études basées sur l'utilisation d'un tripeptide phosphorylé protégé par un fluorénylméthoxycarbonyle (Fmoc), qui peut s'auto-assembler en hydrogel. Dans la première étude, différentes conditions de préparation (pH, sel, présence de polysaccharide) ont été étudiées pour former un hydrogel autocicatrisant et antibactérien libérant un antibiotique, le florfénicol. Dans la seconde étude, des stratégies de synthèse peptidiques et de phosphoramidites en phase solide ont été combinées pour ajouter le florfénicol au phosphate de tyrosine protégé par le Fmoc via un phosphodiester, clivable par des nucléases produites par des bactéries. Des résultats encourageants ont montré la formation du composé ciblé, ouvrant la voie au design d'un peptide antibactérien auto-défensif
Hydrogels are 3D networks of fibers that retain large amounts of water when swollen. Due to their biocompatibility, they are increasingly used for drug delivery. To develop antibacterial peptide-based hydrogels, this dissertation presents two studies based on the use of a fluorenylmethoxycarbonyl (Fmoc)-protected phosphorylated tripeptide that can self-assemble into a hydrogel. In the first study, different preparation conditions (pH, salt, presence of polysaccharide) were investigated to obtain a self-healing and antibacterial hydrogel capable of releasing an antibiotic, florfenicol. In the second study, a solid-phase peptide and phosphoramidite synthesis strategies were combined to add florfenicol to the Fmoc-protected tyrosine phosphate via a phosphodiester, which can be cleaved by nucleases produced by bacteria. Encouraging results showed the formation of the targeted compound, paving the way for the design of a self-defensive antibacterial peptide
4

Salick, Daphne Ann. "Cytocompatibility, antibacterial activity and biodegradability of self-assembling beta-hairpin peptide-based hydrogels for tissue regenerative applications." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 209 p, 2009. http://proquest.umi.com/pqdweb?did=1674096141&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Belda, Marín Cristina. "Silk bionanocomposites : design, characterization and potential applications." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2570.

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Les « bionanocomposites » à base de soie sont des matériaux qui suscitent un intérêt croissant dans de nombreuses applications, et en particulier dans le domaine biomédical, de par leur capacité à combiner les propriétés de la fibroïne (biodégradabilité, biocompatibilité et propriétés mécaniques intéressantes) et celles des nanoparticules (NP). L’objectif de ce travail est de (i) développer une méthode efficace, et « facile » à mettre en oeuvre, permettant l’élaboration de plusieurs types de bionanocomposites de soie ; (ii) fournir une caractérisation approfondie pour une meilleure compréhension de l’interface soie/NP ; et (iii) présenter des applications pertinentes en relation avec les propriétés spécifiques de ces bionanocomposites. Pour ce faire, les NP, d’or (Au NP), d’argent (Ag NP) et d’oxyde de fer (IONP) ont été utilisées en raison de leurs propriétés bien connues. L’élaboration de bionanocomposites à base de soie, tels que les tissus électrofilées, hydrogels, aérogels, éponges et structures imprimés en 3D est décrite. Une caractérisation approfondie, y compris des mesures in situ (pendant la formation du gel) et des analyses ex situ (une fois le gel formé), des hydrogels de soie montre qu’aucune différence significative n’est observée dans la structure de l’hydrogel, alors que la biocompatibilité des matériaux est préservée. Enfin, une application potentielle pour chaque « bionanocomposite » est présentée. Dans une perspective biomédicale, les hydrogels soie-Ag NP montrent une activité antibactérienne significative. Les hydrogels soie-IONP, implantés dans le cerveau d’un rat et suivis par imagerie de résonance magnétique (IRM), montrent l’induction d’une procédure de régénération du cerveau pendant au moins 3 mois. Dans une perspective liée à la dépollution, les hydrogels soie-Au NP montrent des performances remarquables dans la catalyse de la réaction de réduction du bleu de méthylène par le borohydrure de sodium
Silk-based bionancompoistes have attracted a growing interest in numerous applications, particularly in the biomedical field, owing to their ability to combine the specific properties of silk fibroin (biodegradability, biocompatibility and interesting mechanical properties) and nanoparticles (NPs). This work aims to (i) develop a straightforward, yet efficient, methodology to design various silk bionanocomposite materials; (ii) provide an in-depth characterization regarding the silk/NPs interface and (iii) provide potential applications which are relevant for the use of these bionanocompoistes. To this end, gold (Au NPs), silver (Ag NPs) and iron oxide (IONPs) NPs are used as model nanomaterials due to their well-known properties. The successful design of silk bionancocomposite electrospun mats, hydrogels, cryogels, sponges and 3D printed structures is described. An in-depth characterization, including in situ (during hydrogel formation) and ex situ (once hydrogel is formed), of silk hydrogel bionanocomposites do not reveal any noticeable structural changes of silk hydrogels, while their biocompatibility is not impacted by the incorporation of NPs. Finally, a potential application for each bionanocomposite is presented. In a biomedical perspective, silk-Ag NPs hydrogels bionanocomposites show significant antibacterial activity. Silk-IONPs hydrogel bionanocomposites are implanted into rat’s brain allowing a good monitoring of the implant by magnetic resonance imaging and inducing a brain regeneration process up to 3 months. In depollution perspective, silk-Au NPs hydrogel bionanocomposites show remarkable ability to adsorb and catalyze the reduction of methylene blue dye by sodium borohydride
6

Smith, Samuel Lewis. "An EPR study of antibacterial systems containing hydrogen peroxide." Thesis, Cardiff University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422080.

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Unosson, Erik. "Antibacterial Strategies for Titanium Biomaterials." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-249181.

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Titanium and titanium based alloys are widely used in dentistry and orthopedics to replace hard tissue and to mend broken bones. It has become a material of choice due to its low density, high strength, good biocompatibility and its capacity to integrate closely with the bone. Today, modern materials and surgical techniques can enable patients to live longer, and aid in maintaining or regaining mobility for a more fulfilling life. There are, however, instances where implants fail, and one of the primary causes for implant failure is infection. This thesis deals with two possible ways of reducing or eliminating implant associated infections; TiO2 photocatalysis, where a surface can become antibacterial upon irradiation with UV light; and incorporation of silver, where a subsequent release of silver metal ions result in an antibacterial effect. For the TiO2 photocatalysis strategy, a simple and cost effective chemical oxidation technique, using hydrogen peroxide (H2O2) and water, was used to create an active TiO2 surface on titanium substrates. This surface was shown to effectively degrade an organic model substance (rhodamine B) by generating reactive oxygen species (ROS) under UV illumination. However, it was shown that Ti-peroxy radical species remaining in the surface after the H2O2-oxidation process, rather than generation of ROS from a heterogeneous photocatalytic process, was responsible for the effect. This discovery was further exploited in a TiO2/H2O2/UV system, which demonstrated synergy effects in both rhodamine B degradation tests and in antibacterial assays. For the silver ion release strategy, a combinatorial materials science approach was employed. Binary Ag-Ti oxide gradients were co-deposited in a reactive (O2) environment using a custom built physical vapor deposition system, and evaluated for antibacterial properties. The approach enabled synthesis and composition-structure-property evaluation unlikely to have been achieved by traditional means, and the gradient coatings demonstrated antibacterial properties against both S. aureus and S. epidermidis according to silver ion release. The release was shown to depend more on structural features, such as surface area, crystallinity and oxidation state, than on composition. Ag-Ti oxide gradients were also evaluated under UV illumination, as Ag deposits on crystalline TiO2 can enhance photocatalytic properties. In this work, however, the TiO2 was amorphous and UV illumination caused a slight reduction in the antibacterial effect of silver ions. This was attributed to a UV-induced SOS response in the S. epidermidis bacteria. The results of this thesis demonstrate that both TiO2 photocatalysis, or UV induced activation of Ti-peroxy radical species, as well as incorporation of silver are viable antibacterial strategies for titanium biomaterials. However, their clinical applications are still pending risk-benefit analyses of potential adverse host tissue responses.
8

GOLOB, SAMUEL. "INNOVATIVE ANTIBACTERIAL SYSTEMS FOR ORTHOPEDIC AND TRAUMATOLOGY APPLICATIONS." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2907984.

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Le infezioni ortopediche sono una problematica devastante che colpisce il 2% dei pazienti che si sottopongono ad interventi di sostituzione articolari. Il lavoro di ricerca di questo dottorato ha come scopo l'individuazione di sistemi tecnologicamente innovativi per la profilassi e la cura di tali infezioni.
9

Shi, Guoqiang. "Preparation and properties of polymeric bacteriostatic composite hydrogel." Магістерська робота, Kyiv National University of Technology and Design, 2021. https://er.knutd.edu.ua/handle/123456789/19545.

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The master's thesis is devoted to developing and preparing a composite hydrogel material that can meet the long-term antibacterial properties through a simple physical cross-linking method. The specific research content is as follows: Using PVA and PHMG as raw materials, without introducing initiator and cross-linking agent, through the freezing-thawing method, an antibacterial hydrogel material was prepared. By controlling the PHMG content, freezing time, the number of freeze-thaw cycles and other conditions, the performance of the hydrogel can be adjusted. The best formulation of the hydrogel is found through characterization methods such as light transmittance, swelling rate, dissolution rate, mechanical properties, biocompatibility, and in vitro antibacterial. Prove that the hydrogel has excellent performance-especially long-term antibacterial ability and safety.
Магістерська робота присвячена розробці та виготовленню композитного гідрогелевого матеріалу, який може мати довготривалі антибактеріальні властивості за допомогою простого фізичного методу поперечного зшивання. Зміст дослідження полягає в наступному. Використовуючи в якості сировини ПВА та ПГМГ, без введення ініціатора та зшиваючого агента методом заморожування-розморожування було виготовлено антибактеріальний гідрогелевий матеріал. Контролюючи вміст ПГМГ, час заморожування, кількість циклів заморожування-відтавання та інші умови, можна регулювати рівень характеристик гідрогелю. Найкращий склад гідрогелю знайдено шляхом дослідження таких характеристик, як світлопропускання, швидкість набухання, швидкість розчинення, механічні властивості, біосумісність та антибактеріальний ефект in vitro. Доведено, що гідрогель має чудові характеристики, особливо довгострокові антибактеріальні властивості та безпечність у застосуванні.
Магистерская работа посвящена разработке и изготовлению композитного гидрогелевого материала, который может обладать длительными антибактериальными свойствами с помощью простого физического метода поперечной сшивки. Содержание исследования состоит в следующем. Используя в качестве сырья ПВА и ПГМГ, без введения инициатора и сшивающего агента методом замораживания-размораживания был изготовлен антибактериальный гидрогелевый материал. Контролируя содержание ПГМГ, время замораживания, количество циклов замораживания-оттаивания и другие условия можно регулировать уровень характеристик гидрогеля. Лучший состав гидрогеля найден путем исследования таких характеристик, как светопропускание, скорость набухания, скорость растворения, механические свойства, биосовместимость и антибактериальный эффект in vitro. Доказано, что гидрогель обладает отличными характеристиками, особенно долгосрочными антибактериальными свойствами и безопасностью в применении.
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Deng, X., B. Huang, Q. Wang, W. Wu, Philip D. Coates, Farshid Sefat, C. Lu, W. Zhang, and X. Zhang. "A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing." ACS PUBLICATION, 2021. http://hdl.handle.net/10454/18387.

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Abstract:
Yes
Antibacterial hydrogels have been intensively studied due to their wide practical potential in wound healing. However, developing an antibacterial hydrogel that is able to integrate with exceptional mechanical properties, cell affinity, and adhesiveness will remain a major challenge. Herein, a novel hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate− dopamine (Alg-DA) chains to cross-link with the copolymer chains of acrylamide and acrylic acid (PAM) via triple dynamic noncovalent interactions, including coordination, electrostatic interaction, and hydrogen bonding. The cationized nanofibrillated cellulose (CATNFC), which was synthesized by the grafting of long-chain quaternary ammonium salts onto nanofibrillated cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine (Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both preventing bacterial infection and promoting tissue regeneration during wound healing processes.
This work was supported by the National Natural Science Foundation of China (32070826 and 51861165203), the Chinese Postdoctoral Science Foundation (2019M650239, 2020T130762), the Sichuan Science and Technology Program (2019YJ0125), the State Key Laboratory of Polymer Materials Engineering (sklpme2019-2-19), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2018jcyjAX0807), Chongqing Medical Joint Research Project of Chongqing Science and Technology Committee & Health Agency (2020GDRC017), and the RCUK China-UK Science Bridges Program through the Medical Research Council, and the Fundamental Research Funds for the Central Universities.
The full-text of this article will be released for public view at the end of the publisher embargo on 12 Feb 2022..
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Books on the topic "Antibacterial hydrogels":

1

Yazici, Hilal, and Thomas J. Webster. Biomedical Nanomaterials: From Design to Implementation. Institution of Engineering & Technology, 2016.

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Yazici, Hilal, and Thomas J. Webster. Biomedical Nanomaterials: From Design to Implementation. Institution of Engineering & Technology, 2016.

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Book chapters on the topic "Antibacterial hydrogels":

1

Chahardehi, Amir Modarresi, Mohammad Barati, Iman Zare, and Ebrahim Mostafavi. "Antibacterial and Antiviral Hydrogels." In ACS Symposium Series, 89–120. Washington, DC: American Chemical Society, 2024. http://dx.doi.org/10.1021/bk-2024-1472.ch003.

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Bala, Jyoti, Anupam J. Das, and Ajeet Kaushik. "Antibacterial Hydrogels and Their Implications." In Intelligent Hydrogels in Diagnostics and Therapeutics, 123–34. First edition. | Boca Raton, FL : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781003036050-9.

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Nadtoka, O., P. Virych, O. Krupka, V. Smokal, O. Kharchenko, S. Nadtoka, V. Pavlenko, and N. Kutsevol. "Hybrid Hydrogels with Biologically Active Dyes and Their Antibacterial Efficacy." In Springer Proceedings in Physics, 323–36. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74800-5_23.

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Mišković-Stanković, Vesna, and Teodor Atanackovic. "Hydrogels Aimed for Wound Dressings and Soft Tissue Implants." In Novel Antibacterial Biomaterials for Medical Applications and Modeling of Drug Release Process, 4–123. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781032668895-2.

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Malhotra, Kamal, and Yashveer Singh. "Antibacterial Polymeric and Peptide Gels/Hydrogels to Prevent Biomaterial-Related Infections." In Racing for the Surface, 543–81. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-34475-7_23.

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Çatiker, E., T. Filik, and E. Çil. "Antibacterial Activity of Hyperbranched Poly(Acrylic Acid-Co-3-Hydroxypropionate) Hydrogels." In Science and Technology of Polymers and Advanced Materials, 395–402. Includes bibliographical references and index.: Apple Academic Press, 2019. http://dx.doi.org/10.1201/9780429425301-28.

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Reiter, Bruno. "The Lactoperoxidase-Thiocyanate-Hydrogen Peroxide Antibacterium System." In Novartis Foundation Symposia, 285–94. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470715413.ch16.

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Tajik, Faezeh, Niloofar Eslahi, and Aboosaeed Rashidi. "Fabrication of Antibacterial PVP/Keratin Hydrogel Embedded with Lavender Extract." In Eco-friendly and Smart Polymer Systems, 294–96. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45085-4_70.

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Yan, Jun, Yifan Cui, Dehong Cheng, Jiarui Cao, Qianxi Zhou, Yanhua Lu, and Hong Li. "Swelling Behavior and Antibacterial Property of Sericin/NIPAAm/AgNPs Semi-IPN Hydrogel." In Lecture Notes in Electrical Engineering, 1935–41. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5959-4_235.

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Rauf, Abdur, Shehla Khan, Zubair Ahmad, and Hassan A. Hemeg. "Chapter 5 Hydrogel in wound dressing and burn dressing products with antibacterial potential." In Hydrogels, 67–78. De Gruyter, 2024. http://dx.doi.org/10.1515/9783111334080-005.

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Conference papers on the topic "Antibacterial hydrogels":

1

Aykaç, Ahmet, and İzel Ok. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.046.

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Hydrogels are biocompatible and swollen materials that have been used as a wound dressing for years. Among them, chitosan-based hydrogels have become popular in the wound healing process owing to their low toxic, biocompatible, biodegradable, antibacterial properties. Chitosan (CS) has been used either as a pure form or incorporated with polymers or nanoparticles to increase antimicrobial activity and stability. In this context, zinc oxide nanoparticles (ZnO NPs) have been used to enhance antibacterial activity and mesoporous silica nanoparticles (MSN) have been employed to develop mechanical strength and control of drug release time. In this study, we report the synthesis and fully characterizations of ZnO NPs, MSN and the hydrogel by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR). We have also prepared and characterized chitosan-based hydrogels functionalized by MSNs and ZnO NPs.
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Pholpabu, Pitirat, Pattira Somharnwong, Nattathida Huaybun, Chanatip Cherdbaramee, Vichapas Boonpasart, Lakkhanabut Komchum, and Achiya Phuengsap. "Controlled Release of Dual Antibacterial Drug from Composite Hydrogels." In 2019 12th Biomedical Engineering International Conference (BMEiCON). IEEE, 2019. http://dx.doi.org/10.1109/bmeicon47515.2019.8990291.

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Saeednia, L., A. Usta, and R. Asmatulu. "Preparation and Characterization of Drug-Loaded Thermosensitive Hydrogels." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-66489.

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Hydrogels are the promising classes of polymeric drug delivery systems with the controlled release rates. Among them, injectable thermosensitive hydrogels with transition temperature around the body temperature have been wildly considered. Chitosan is one of the most abundant natural polymers, and its biocompatibility and biodegradability makes it a favorable thermosensitive hydrogel that has been attracted much attention in biomedical field worldwide. In this work, a thermosensitive and injectable hydrogel was prepared using chitosan and β-glycerophosphate (β-GP) incorporated with an antibacterial drug (gentamycin). This drug loaded hydrogel is liquid at room temperature, and becomes more solidified gel when heated to the body temperature. Adding β-GP into chitosan and drug molecules and heating the overall solution makes the whole homogenous liquid into gel through a 3D network formation. The gelation time was found to be a function of temperature and concentration of β-GP. This thermosensitive chitosan based hydrogel system was characterized using FTIR and visual observation to determine the chemical structure and morphology. The results confirmed that chitosan/(β-GP) hydrogels could be a promising controlled-release drug delivery system for many deadly diseases.
4

Vasile, Georgiana, Andreea Țigău, Alina Popescu, Rodica Roxana Constantinescu, and Laura Chirilă. "Hydrogels-Based Textile Materials for Treatment of First-Degree Burn Injuries." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.28.

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Hydrogels based on collagen and xanthan have found various applications as drug delivery carriers. The main strategy is to combine the traditional perspective of using essential oils with polymeric hydrogels in order to develop a potential dressing that provides wound healing for first-degree burn injuries. In this regard, the present study is aimed to develop textile materials with potential for use in the treatment of first-degree burn injuries by approaching the hydrogels based on xanthan gum and collagen as polymeric matrix loaded with essential oils (cinnamon essential oil, tea tree essential oil), propolis (hydroglyceric extract or with content of colloidal silver) and drugs (chlorhexidine, ciprofloxacin). A total of six experimental variants of hydrogels were synthesized and then were applied by padding method on a plain weave textile structure from 100% cotton. The functionalized textile materials were characterized by morphological and antibacterial point of view. The textile materials treated materials with all synthesized hydrogels based on xanthan and collagen as polymeric matrices have antibacterial activity against S. aureus and E. coli test strains, the highest inhibition zone was provided by the samples loaded with ciprofloxacin (MUP3 and MUP4 code).
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Țigău, Andreea, Georgiana Vasile, Alina Popescu, Rodica Roxana Constantinescu, and Laura Chirilă. "Hydrogel Dressings with Antimicrobial and Healing Properties." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.25.

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The current study aimed to develop hydrogels as delivery systems based on a mixture of biodegradable and biocompatible polymers (i.e., gelatin and collagen) for encapsulating different active principles (i.e., chamomile and plantain tincture, aloe vera and propolis) to obtain dressings for treating first-degree burns injuries. The synthesized hydrogels were then immobilized on a textile material made from 100% cotton fibers. The functionalized textile materials were analyzed in terms of physical-mechanical characteristics, water absorbency and antibacterial activity. SEM analysis was used to investigate the morphology of the cotton fibers after the functionalized treatment. The antibacterial activity of the treated samples was qualitatively assessed through the Agar diffusion method by using cultures in a liquid medium of S. aureus and E. coli test strains. The obtained overall results indicated that incorporating of these active principles into the polymeric hydrogels can significantly enhance the potential efficiency of the fabrics as dressings with antimicrobial and healing accelerating properties and can be an appropriate option for treating first-degree burns injuries.
6

Nadtoka, Oksana, Tetiana Bezugla, Antonina Naumenko, Pavlo Virych, and Nataliya Kutsevol. "Silver Nanoparticles-based Hydrogel for Potential Antibacterial Applications." In 2019 IEEE 8th International Conference on Advanced Optoelectronics and Lasers (CAOL). IEEE, 2019. http://dx.doi.org/10.1109/caol46282.2019.9019520.

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7

Yiamsawas, D., K. Boonpavanitchakul, R. Sangsirimongkolying, and W. Kangwansupamonkon. "Polyacrylic acid based hydrogel-silver nanoparticles for antibacterial applications." In 2008 International Conference on Nanoscience and Nanotechnology (ICONN). IEEE, 2008. http://dx.doi.org/10.1109/iconn.2008.4639253.

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8

Chasanah, Uswatun, A. B. Apriliyanto, D. Anggara, Ayu Kusumawardani, and Dian Ermawati. "Characterization and Antibacterial Activity of Dayak Onion (Eleutherine palmifolia) Hydrogel in Vitro." In The Health Science International Conference. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009126201640170.

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Saputra, Asep Handaya, and Inne Puspita Sari. "Development of CMC-based antibacterial hydrogel from water hyacinth with silver nanoparticle addition." In SolarPACES 2017: International Conference on Concentrating Solar Power and Chemical Energy Systems. Author(s), 2018. http://dx.doi.org/10.1063/1.5064316.

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Aljeboree, Aseel M., Zainab D. Alhattab, Sarah A. Hamood, Saif Yaseen Hasan, and Ayad F. Alkaim. "Enhanced Pollutant Adsorption and Antibacterial Activity of a Hydrogel Nanocomposite Incorporating Titanium Dioxide Nanoparticles." In RAiSE-2023. Basel Switzerland: MDPI, 2024. http://dx.doi.org/10.3390/engproc2023059189.

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