Dissertations / Theses on the topic 'Anti-infective agents'
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Osborne, Sadie D. "Synthesis of carbohydrate based anti-infective agents." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394179.
Full textAllcock, Robert William. "The synthesis and evaluation of some anti-infective agents." Thesis, Nottingham Trent University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341277.
Full textKanwar, Ankush. "Studies Aimed at the Synthesis of Anti-Infective Agents." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7176.
Full textAlamu, Josiah Olusegun Herwaldt Loreen A. "Evaluation of antimicrobial use in a pediatric intensive care unit." Iowa City : University of Iowa, 2009. http://ir.uiowa.edu/etd/277.
Full textPütsep, Katrin. "On the control of the microflora in the gastro intestinal tract : functional examples of antibacterial peptides from Helicobacter pylori and mouse small intestine /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4267-6/.
Full textGiraldi, Cátia. "Enterococcus isolados de alimentos: caracterização molecular e perfil de resistência a antimicrobianos." Universidade Tecnológica Federal do Paraná, 2014. http://repositorio.utfpr.edu.br/jspui/handle/1/1136.
Full textEnterococci are pathogens with considerable ability to express resistance to multiple antimicrobials and abundant representation in foods. This study aimed to carry out the isolation of strains of the genus Enterococcus in food, represented by chicken and pork (raw and processed), to analyze the profile of antimicrobial resistance by the disk diffusion method and by molecular techniques to identify species isolates and genes encoding resistance to vancomycin and tetracycline. 36 samples, totaling 54 strains belonging to the genus Enterococcus were analyzed. The species detected in most occurred in isolates from raw chicken meat (40 %) and raw pork (29%) was isolated in E. faecalis and processed meat products (100%) E. faecium. E. casseliflavus / E. flavencens had its isolation only in the processed product. The species E. gallinarum was confirmed between food samples surveyed. E. faecalis and E. faecium isolates from raw chicken meat isolated were significantly more resistant than the other samples, showing high percentage of resistance to: streptomycin, ciprofloxacin, norfloxacin, erythromycin, vancomycin and tetracycline. The isolated raw poultry and swine gene showed resistance to tetracycline and vancomycin. Therefore, it is suggested that food of animal origin may play an important role in the dissemination and transfer resistant enterococci and / or resistance genes to humans.
Kasanah, Noer. "Marine anti-infective agents : bioactivity, microbial production, biotransformation and biosynthetic study /." Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1850412761&SrchMode=1&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1279226241&clientId=22256.
Full textSherrill, Jennifer Lynne. "Surface modification of nylon 6,6 to form Light-Activated Antimicrobial Materials (LAAMS)." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/18964.
Full textEverett, Lucy Margaret. "The effects of antibiotic stress on the expression of virulence factors by strains of Staphylococcus aureus diplaying vancomycin-intermediate resistance." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272854.
Full textToft, Simonsen Henrik. "Ethnopharmacological and phytochemical investigation of Melicope species from Réunion Island /." Cph. : Department of Medicinal Chemistry, Royal Danish School of Pharmacy, 2002. http://www.dfh.dk/phd/defences/Henrik%20Toft%20Simonsen.html.
Full textTong, Carmen. "Screening for inhibitors of Staphylococcal Sortase A as novel anti-infective agents." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/53236/.
Full textKhara, Jasmeet. "De novo design of antimicrobial peptides for application as anti-infective agents." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/45283.
Full textSvinhufvud, Lillemor Borthen. "Selective modulation of the oropharyngeal microflora with topical administration of antimicrobial agents." Stockholm : Kongl Carolinska Medico Chirurgiska Institutet, 1987. http://catalog.hathitrust.org/api/volumes/oclc/16150025.html.
Full textMustafa, Manal. "Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-714-2.
Full textKhadambi, Tshiwela Norah. "Antimicrobial properties of phenolic compounds from sorghum." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-03022007-164705.
Full textMativandlela, Sannah Patience Nkam. "Evaluation of isolates and identified phenolics from pelargonium sidiodes against tuberculosis, other bacteria and fungi." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-02132006-113925.
Full textAli, Saleh A. "Antimicrobial and antioxidant activity of two desert truffles, Tirmania and Terfezia." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99316.
Full textPalenske, Nicole Marie Dzialowski Edward. "Effects of triclosan, triclocarban, and caffeine exposure on the development of amphibian larvae." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11016.
Full textVan, Eeden Nestor. "Synthesis of some potential antimicrobial carbocyclic compounds." Thesis, Cape Technikon, 1994. http://hdl.handle.net/20.500.11838/745.
Full textSome naturally occurring compounds containing the naphtho [2,3 - c] pyran ring system have been found to be useful antibiotic agents and thus the laboratory synthesis ofthese compounds and their derivatives are of importance in the medical field. Their antibiotic and even antineoplastic activities are attributed to their potential to act as alkylating agents, via a bioreductive process. This thesis deals with studies directed towards the synthesis of some benzo [c] pyrans as these compounds also possess the correct structural configuration to undergo the bioreductive process, and act as alkylating agents to cellular nucleic acids. Chapter Two describes the synthesis 00,4 dihydro - 1,3 - dimethyl- IH - benzo - [cl pyran - 5,8 - quinone (13) by employing a base induced cyclization with potassium tertiary butoxide. This compound was proven to be biologically active against both Gram positive and Gram negative organisms. (±) (1R, 3R, 4R) - 3,4 - Dihydro - 4 - hyroxy -1,3 - dimethyl- 1H - benzo [e] pyran - 5,8quinone (17) and its 4 S diastereomer (18) were synthesized with cerium (IV) ammonium nitrate as the cyclizing reagent. Antimicrobial evaluation ofcompound (17) displayed inhibitory activity against both Gram positive and Gram negative organism growth. This is discussed in Chapter Three. In Chapter Four, the synthesis ofthe benzo analogue ofthe naturally occurring naphthopyran antibiotic, hongconin, is discussed. The synthetic route used for this synthesis could well be applied to synthesise hongconin.
Amaral, Lílian Ferreira Barbosa 1978. "Avaliação da segurança e eficácia do extrato de Caryocar brasiliense obtido por CO2 supercrítico e sua aplicação como ativo para formulações antissépticas." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312995.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-26T03:28:14Z (GMT). No. of bitstreams: 1 Amaral_LilianFerreiraBarbosa_D.pdf: 2465793 bytes, checksum: e61ffae5669fa378935586624f7137b2 (MD5) Previous issue date: 2014
Resumo: As indústrias cosméticas e farmacêuticas têm um crescente interesse na substituição dos antimicrobianos sintéticos nos produtos dermatológicos, devido à resistência dos microrganismos aos antimicrobianos convencionais. O pequi (Caryocar brasiliense Camb) é uma frutífera nativa do Cerrado brasileiro utilizada na medicina popular, na indústria cosmética e na alimentação, com atividades leishmanicida e antimicrobiana descritas na literatura. O objetivo principal deste trabalho foi avaliar a segurança e a eficácia do extrato de Caryocar brasilense obtido por CO2 supercrítico visando sua aplicação cosmética. A concentração inibitória mínima (CIM) frente às bactérias Escherichia coli, Pseudomonas aeruginosa e Staphylococcus aureus foi determinada pelo método clássico de microdiluição em placas. O potencial antioxidante do extrato foi determinado por um método baseado na oxidação do 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). Para avaliação da citotoxicidade e fototoxicidade in vitro, foram utilizados métodos colorimétricos baseados na conversão do corante tetrazólio (XTT) e o método do vermelho neutro (3T3 NRU), respectivamente. Na avaliação do potencial de irritação ocular empregou-se o teste na membrana corioalantóide do ovo de galinha (HET-CAM). O Perfil fitoquímico do extrato foi analisado quanto à presença de alcalóides, saponinas, antraquinonas, esteróides, taninos, flavonóides e compostos fenólicos, de acordo com métodos colorimétricos padronizados. Os resultados obtidos indicam que o extrato de Caryocar brasilense obtido por CO2 supercrítico demonstra atividade antimicrobiana frente às bactérias testadas, além de potencial antioxidante comparado ao padrão testado. Adicionalmente, o extrato de Caryocar brasilense obtido por CO2 supercrítico não apresenta efeitos tóxicos, mostrando-se um extrato seguro. Estes resultados fornecem perspectivas de desenvolvimento de produtos para o cuidado pessoal, principalmente aqueles com atividade antisséptica e os que minimizam os danos causados pelos radicais livres
Abstract: The cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials in dermatological products due to increased microbial resistance to conventional antimicrobial agents. Caryocar brasiliense Camb (pequi) is a typical Brazilian Cerrado fruit tree. Its fruit is used as a vitamin source for culinary purposes and as a source of oil for the manufacture of cosmetics. Leishmanicidal and antimicrobial activities have been reported previously. This study was designed to evaluate the safety and efficacy of C. brasiliense extract obtained by supercritical CO2 extraction. The minimum inhibitory concentrations (MICs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were determined by the classical microdilution method. Antiseptic activity against these organisms was evaluated by the plate diffusion method. The antioxidant potential of the extract was evaluated using a method based on the oxidation of 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). In vitro cytotoxicity and phototoxicity of C. brasiliense supercritical CO2 extracts were assessed using a tetrazolium-based colorimetric assay (XTT) and Neutral Red methods; eye irritation potential was assessed using the Hen's Egg Test ¿ Chorioallantoic Membrane (HET-CAM) Test Method. The extract¿s chemical profile was analyzed for the presence of alkaloids, saponins, anthraquinones, steroids, tannins, flavonoids, and phenolic compounds according to standard colorimetric methods. The C. brasiliense supercritical CO2 extract exhibits antimicrobial activity against all bacteria tested. It also possesses antioxidant activity, when compared to a vitamin E standard. We also found that the C. brasiliense (pequi) extract obtained by supercritical CO2 extraction did not present cytotoxic and phototoxic hazards This finding suggests that C. brasiliense supercritical may be useful for the development of cosmetic and/or pharmaceutical products, primarily for antiseptic skin products that inactivate, reduce, prevent, or arrest the growth of microorganisms with the inherent intent to mitigate or prevent disease as well as products that minimize damage caused by free radicals
Doutorado
Ciencias Biomedicas
Doutora em Ciências Médicas
Samosorn, Siritron. "Development of berberine-based derivatives as novel antimicrobial agents." Access electronically, 2005. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20050819.161843/index.html.
Full textHevener, Kirk Edward. "Structure- and ligand-based design of novel antimicrobial agents." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-052-Hevener-index.htm.
Full textTitle from title page screen (viewed on February 2, 2009). Research advisor: Richard E. Lee, Ph.D. Document formatted into pages (xviii, 238 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 167-186).
Wilson, Jason B. "Synthesis and evaluation of tetramic acids as antimicrobial agents." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-055-Wilson-Index.htm.
Full textTitle from title page screen (viewed on February 27, 2009). Research advisor: Richard E. Lee, Ph.D. Document formatted into pages (viii, 40 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 36-40).
Dorrington, Tarquin. "Recombinant antimicrobials for feed based delivery in aquaculture /." View online ; access limited to URI, 2005. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3188058.
Full text張麗 and Li Zhang. "Interactions of Bismuth complexes with biomolecules: insight into the mechanism of action of Bismuthantimicrobial agents." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3124631X.
Full textTohidi, Fatemeh. "Environmental occurrence of triclosan in wastewater and transformation fate and development of a method of derivatization of PFOS." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/285.
Full textPadua, Roberto R. "Purification and characterization of an antimicrobial compound secreted by a soil bacterium /." Abstract Full Text (HTML) Full Text (PDF), 2008. http://eprints.ccsu.edu/archive/00000530/02/1979FT.htm.
Full textThesis advisor: Michael A. Davis. "... in partial fulfillment of the requirements for the degree of Master of Arts in Biomolecular Sciences." Includes bibliographical references (leaves 36-39). Also available via the World Wide Web.
Gedikoglu, Ayca Clarke Andrew Douglas. "Effect of antimicrobial agents on physical, chemical and microbiological characteristics of ready-to-eat bologna." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/5777.
Full textTsoi, Hoi-wah. "Effect of antibiotics on the immune response induced by live-attenuated Salmonella typhi /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2121315X.
Full textWicht, Merrill Margaret. "Oleanolic acid: its isolation and derivatisation to potential antimicrobial compounds." Thesis, Cape Peninsula University of Technology, 2007. http://hdl.handle.net/20.500.11838/738.
Full textAn increasing number of natural products possessing the oleanolic acid moiety have been shown to demonstrate a wide spectrum of biological activity. This thesis deals with the extraction and isolation of oleanolic acid from Syzigium aromaticum and the examination of its stereochemistry and crystal structure by X-ray diffraction. The synthetic routes used for converting functional groups on the oleanolic acid molecule to afford derivatives are described in Chapter 5. Oleanolic acid and its derivatives were evaluated for antimicrobial activity. Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt chemosensitivity were used. Acceptable results were obtained from the last method and these were used to arrive at conclusions regarding this study.
Lindbäck, Emma. "Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-688-3/.
Full textMcBride, Kent Alexander. "An in vitro assessment of an engineered cationic antimicrobial peptide (eCAP) against planktonic strains of E. faecalis." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5241.
Full textTitle from document title page. Document formatted into pages; contains viii, 33 p. : col. ill. Vita. Includes abstract. Includes bibliographical references (p. 26-31).
Riesbeck, Kristian. "Effects of fluoroquinolones on the immune system." Malmö : Dept. of Medical Microbiology, Lund University, Malmö General Hospital, 1994. http://books.google.com/books?id=-hRtAAAAMAAJ.
Full textWahyuono, Subagus. "Potential anti-infective agents isolated from Artemisia pacifica Nutt and Guardiola platyphylla Gray (fam. Asteraceae)." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185386.
Full textChia, Brian Cheng San. "Amphibian antimicrobial peptides : their structures and mechanisms of action : a thesis presented for the degree of Doctor of Philosophy." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phc532.pdf.
Full textDudley, Dawn M. "HIV-1 Env impacting HIV-1 fitness, entry inhibitor drug sensitivity, and in vivo selection of a resistant virus to the microbicide PSC-Rantes /." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1186757280.
Full text[School of Medicine] Department of Molecular Biology and Microbiology. Includes bibliographical references. Available online via OhioLINK's ETD Center.
Neetoo, Swaleha Hudaa. "Effectiveness of antimicrobial packaging in controlling the growth of Listeria monocytogenes on cold-smoked salmon." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 131 p, 2007. http://proquest.umi.com/pqdweb?did=1338870431&sid=10&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textJalal, Shah. "Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4447-4/.
Full textHo, Wing-yin Queenie, and 何穎賢. "Antimicrobial use & resistance in China: implications for public health in Hong Kong : an exploratoryanalysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46937092.
Full textAnyaogu, Kelechi C. "Stabilized metal nanoparticle-polymer composites preparation, characterization and potential applications /." Bowling Green, Ohio : Bowling Green State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1222126708.
Full textLiu, Meilin. "Effects of the antimicrobial agent Triclosan on bacterial resistance to disinfection in wastewater treatment processes." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5996.
Full textTitle from document title page. Document formatted into pages; contains viii, 55 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 52-55).
Martini, Nataly Dominica. "The isolation and characterisation of antibacterial compounds from Combretum erythrophyllum (Burch.) Sond." Diss., Pretoria : [s.n.], 2001. http://upetd.up.ac.za/thesis/available/etd-07092002-153815/.
Full textBarreto, Michael. "Antimicrobial activity of macroalgae from Kwazulu-Natal, South Africa, and the isolation of a bioactive compound from Osmundaria serrata (Rhodophyta)." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-09052005-095635/.
Full textWicht, Merril Margaret. "Oleanic acid: its isolation and derivatisation to potential antimicrobial compounds." Thesis, Cape Peninsula University of Technology, 2007. http://hdl.handle.net/20.500.11838/732.
Full textAn increasing number of natural products possessing the oleanolic acid moiety have been shown to demonstrate a wide spectrum of biological activity. This thesis deals with the extraction and isolation of oleanolic acid from Syzigium aromaticum and the examination of its stereochemistry and crystal structure by X-ray diffraction. The synthetic routes used for converting functional groups on the oleanolic acid molecule to afford derivatives are described in Chapter 5. Oleanolic acid and its derivatives were evaluated for antimicrobial activity. Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt chemosensitivity were used. Acceptable results were obtained from the last method and these were used to arrive at conclusions regarding this study.
Yang, Nan, and 楊楠. "Bismuth based agents and their interactions with the SARS helicase andits metal binding domain." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634504.
Full textOh, Herin. "Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-498-4.
Full textSingh, G. "Antibacterial activity testing of cotton medical textiles sonochemically impregnated with metal oxide nanoparticles." Thesis, Coventry University, 2014. http://curve.coventry.ac.uk/open/items/edeb833b-a792-49eb-bc22-bafbd374bb22/1.
Full textYang, Nan. "Bismuth based agents and their interactions with the SARS helicase and its metal binding domain." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634504.
Full textBernier, Bethany A. "Antimicrobial Effects of Blueberry Products Against Escherichia Coli O157:H7 in Liquid Medium and in Ground Beef." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/BernierBA2005.pdf.
Full textAltunakar, Bilge. "Food preservation by pulsed electric fields and selected antimicrobials." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Dissertations/Fall2007/b_altunakar_120507.pdf.
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