Relevant bibliographies by topics / Anti-biofilm agents

Academic literature on the topic 'Anti-biofilm agents'

Author: Grafiati
Published: 10 December 2022
Last updated: 9 March 2023

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Journal articles on the topic "Anti-biofilm agents"

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Săndulescu, Oana. "Managing sticky situations – anti-biofilm agents." GERMS 6, no. 2 (June 1, 2016): 49. http://dx.doi.org/10.11599/germs.2016.1088.

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S. R., Mahipriyaa, Baby Roselin R, Arjun K., Nithyanth M., and Sankar V. "A REVIEW ON NATURAL ANTI BIOFILM AGENTS FOR WOUND BIOFILM." INDIAN DRUGS 58, no. 10 (December 16, 2021): 7–18. http://dx.doi.org/10.53879/id.58.10.12525.

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A biofilm may be a consortium of micro-organisms in which the cells of microbes attach to each other on a living or non-living surface inside a self-produced matrix of extracellular polymeric substances. The bacterial or fungal colonies invade the surface of the wounds, thereby delaying the healing cascade. The resistance is partially due to low metabolic rate of these colonies, which directly impacts the action of oral or parenteral antibiotics. Hence, there is an urgent need to develop antibacterial agents to regulate the biofilm growth and development. The last few decades have witnessed wide research studies attempting to investigate the anti-biofilm effects of natural products. This review will summarize the wound infections associated with biofilm, mechanisms of bacterial resistance due to biofilm and recent studies on discovery of natural products with their mechanisms for inhibiting various bacterial biofilms that can be a promising candidate which could provide novel strategies for biofilm-associated infections.
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Brackman, Gilles, and Tom Coenye. "Quorum Sensing Inhibitors as Anti-Biofilm Agents." Current Pharmaceutical Design 21, no. 1 (November 18, 2014): 5–11. http://dx.doi.org/10.2174/1381612820666140905114627.

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Al-Adham, I. S. I., N. D. Al-Hmoud, E. Khalil, M. Kierans, and P. J. Collier. "Microemulsions are highly effective anti-biofilm agents." Letters in Applied Microbiology 36, no. 2 (February 2003): 97–100. http://dx.doi.org/10.1046/j.1472-765x.2003.01266.x.

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Jang, Yun Su, and Tímea Mosolygó. "Inhibition of Bacterial Biofilm Formation by Phytotherapeutics with Focus on Overcoming Antimicrobial Resistance." Current Pharmaceutical Design 26, no. 24 (July 21, 2020): 2807–16. http://dx.doi.org/10.2174/1381612826666200212121710.

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: Bacteria within biofilms are more resistant to antibiotics and chemical agents than planktonic bacteria in suspension. Treatment of biofilm-associated infections inevitably involves high dosages and prolonged courses of antimicrobial agents; therefore, there is a potential risk of the development of antimicrobial resistance (AMR). Due to the high prevalence of AMR and its association with biofilm formation, investigation of more effective anti-biofilm agents is required. : From ancient times, herbs and spices have been used to preserve foods, and their antimicrobial, anti-biofilm and anti-quorum sensing properties are well known. Moreover, phytochemicals exert their anti-biofilm properties at sub-inhibitory concentrations without providing the opportunity for the emergence of resistant bacteria or harming the host microbiota. : With increasing scientific attention to natural phytotherapeutic agents, numerous experimental investigations have been conducted in recent years. The present paper aims to review the articles published in the last decade in order to summarize a) our current understanding of AMR in correlation with biofilm formation and b) the evidence of phytotherapeutic agents against bacterial biofilms and their mechanisms of action. The main focus has been put on herbal anti-biofilm compounds tested to date in association with Staphylococcus aureus, Pseudomonas aeruginosa and food-borne pathogens (Salmonella spp., Campylobacter spp., Listeria monocytogenes and Escherichia coli).
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Asma, Syeda Tasmia, Kálmán Imre, Adriana Morar, Viorel Herman, Ulas Acaroz, Hamid Mukhtar, Damla Arslan-Acaroz, Syed Rizwan Ali Shah, and Robin Gerlach. "An Overview of Biofilm Formation–Combating Strategies and Mechanisms of Action of Antibiofilm Agents." Life 12, no. 8 (July 23, 2022): 1110. http://dx.doi.org/10.3390/life12081110.

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Biofilm formation on surfaces via microbial colonization causes infections and has become a major health issue globally. The biofilm lifestyle provides resistance to environmental stresses and antimicrobial therapies. Biofilms can cause several chronic conditions, and effective treatment has become a challenge due to increased antimicrobial resistance. Antibiotics available for treating biofilm-associated infections are generally not very effective and require high doses that may cause toxicity in the host. Therefore, it is essential to study and develop efficient anti-biofilm strategies that can significantly reduce the rate of biofilm-associated healthcare problems. In this context, some effective combating strategies with potential anti-biofilm agents, including plant extracts, peptides, enzymes, lantibiotics, chelating agents, biosurfactants, polysaccharides, organic, inorganic, and metal nanoparticles, etc., have been reviewed to overcome biofilm-associated healthcare problems. From their extensive literature survey, it can be concluded that these molecules with considerable structural alterations might be applied to the treatment of biofilm-associated infections, by evaluating their significant delivery to the target site of the host. To design effective anti-biofilm molecules, it must be assured that the minimum inhibitory concentrations of these anti-biofilm compounds can eradicate biofilm-associated infections without causing toxic effects at a significant rate.
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Wang, Kai-Ling, Zheng-Rong Dou, Gao-Fen Gong, Hai-Feng Li, Bei Jiang, and Ying Xu. "Anti-Larval and Anti-Algal Natural Products from Marine Microorganisms as Sources of Anti-Biofilm Agents." Marine Drugs 20, no. 2 (January 21, 2022): 90. http://dx.doi.org/10.3390/md20020090.

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Bacteria growing inside biofilms are more resistant to hostile environments, conventional antibiotics, and mechanical stresses than their planktonic counterparts. It is estimated that more than 80% of microbial infections in human patients are biofilm-based, and biofouling induced by the biofilms of some bacteria causes serious ecological and economic problems throughout the world. Therefore, exploring highly effective anti-biofilm compounds has become an urgent demand for the medical and marine industries. Marine microorganisms, a well-documented and prolific source of natural products, provide an array of structurally distinct secondary metabolites with diverse biological activities. However, up to date, only a handful of anti-biofilm natural products derived from marine microorganisms have been reported. Meanwhile, it is worth noting that some promising antifouling (AF) compounds from marine microbes, particularly those that inhibit settlement of fouling invertebrate larvae and algal spores, can be considered as potential anti-biofilm agents owing to the well-known knowledge of the correlations between biofilm formation and the biofouling process of fouling organisms. In this review, a total of 112 anti-biofilm, anti-larval, and anti-algal natural products from marine microbes and 26 of their synthetic analogues are highlighted from 2000 to 2021. These compounds are introduced based on their microbial origins, and then categorized into the following different structural groups: fatty acids, butenolides, terpenoids, steroids, phenols, phenyl ethers, polyketides, alkaloids, flavonoids, amines, nucleosides, and peptides. The preliminary structure-activity relationships (SAR) of some important compounds are also briefly discussed. Finally, current challenges and future research perspectives are proposed based on opinions from many previous reviews.
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Raja Yahya, Mohd Fakharul Zaman. "Anti-biofilm Potential and Mode of Action of Malaysian Plant Species: A Review." Science Letters 14, no. 2 (June 1, 2020): 34. http://dx.doi.org/10.24191/sl.v14i2.9541.

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Biofilm is a microbial community that attaches to a surface and is enclosed in extracellular polymeric substance (EPS) matrix. Formation of biofilm often develops resistance towards a wide spectrum of antimicrobial agents. Since the biofilm-mediated diseases are commonly difficult to treat, there is a need to find new anti-biofilm agent. The studies on anti-biofilm activities of plant species have received a great deal of attention over the last few decades. In Malaysia, plant species have been used as alternatives to the conventional antimicrobial therapy. Several Malaysian plant species are known to control biofilm infection by inhibition of quorum sensing pathway, disruption of EPS matrix, alteration of cell permeability and reduction in cell surface hydrophobicity. This review demonstrates that Malaysian plant species may become excellent therapeutic agents in combating the biofilm infection.
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Abedon, Stephen. "Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria." Pharmaceuticals 8, no. 3 (September 9, 2015): 559–89. http://dx.doi.org/10.3390/ph8030559.

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Kaplan, Jeffrey B. "Therapeutic Potential of Biofilm-Dispersing Enzymes." International Journal of Artificial Organs 32, no. 9 (September 2009): 545–54. http://dx.doi.org/10.1177/039139880903200903.

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Surface-attached colonies of bacteria known as biofilms play a major role in the pathogenesis of medical device infections. Biofilm colonies are notorious for their resistance to antibiotics and host defenses, which makes most device infections difficult or impossible to eradicate. Bacterial cells in a biofilm are held together by an extracellular polymeric matrix that is synthesized by the bacteria themselves. Enzymes that degrade biofilm matrix polymers have been shown to inhibit bio film formation, detach established bio film colonies, and render biofilm cells sensitive to killing by antimicrobial agents. This review discusses the potential use of biofilm matrix-degrading enzymes as anti-biofilm agents for the treatment and prevention of device infections. Two enzymes, deoxyribonuclease I and the glycoside hydrolase dispersin B, will be reviewed in detail. In vitro and in vivo studies demonstrating the anti-biofilm activities of these two enzymes will be summarized, and the therapeutic potential and possible drawbacks of using these enzymes as clinical agents will be discussed.
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Dissertations / Theses on the topic "Anti-biofilm agents"

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Huang, Regina. "Red-emitting carbon dots and their biological application as antifungal/anti-biofilm agent." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/745.

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Carbon dots (CD) have emerged as the new eye-catching theranostic nanomaterials due to their distinctive features, including tunable emission, facile surface modification, high biocompatibility and low cytotoxicity. These distinguishing features allow full customizations of CD according to the needs of various studies. Of note, they have been widely employed as nano-vehicles with live-tracking systems in many biological applications to deliver medicine with low bioavailability to targeted sites. Candida albicans, a commonly seen commensal fungus accounts for life-threatening infections in humans, is the leading cause of oral candidiasis. Yet, the efficacy of the "gold standard" Amphotericin B (AmB) has been limited due to poor water solubility and dose-dependent cytotoxicity. In addition, the interactions of CD with Candida cells/biofilms and human epithelial tissues have not been fully investigated, and very limited studies have been done on CD-based antifungal drugs delivery for topical administration. Herein, AmB-conjugated guanylated CD (CD-Gu + -AmB) tackling oral fungal infections were synthesized and possessed potent antifungal/anti-biofilm effects against C. albicans. Moreover, CD-Gu + -AmB exhibit low cytotoxicity to primary human oral keratinocytes and can selectively accumulate in the cell nuclei. Above all, the first evidence of studying the penetration and exfoliation profiles of CD in a three- dimensional organotypic human oral epithelial tissue model was provided, and the accumulation of CD-Gu + -AmB in the epithelial tissue can form a 'shielding' layer on oral epithelia against C. albicans. This study demonstrates that CD-Gu + -AmB may serve as a promising antifungal agent for tackling C. albicans and Candida-induced oral candidiasis through fast epithelial penetration, extra-/intra-cellular embedding and gradual exfoliation
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Verderosa, Anthony Daniel. "Nitroxide functionalised antibiotics for the eradication of bacterial biofilms." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/135167/1/Anthony_Verderosa_Thesis.pdf.

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Bacterial biofilms are a leading cause of life-threatening and device-related infections worldwide. Biofilm related infections are notoriously difficult to treat as they are highly tolerant to conventional antibiotics. This project has designed and synthesised a new class of antibiotics to circumvent biofilm tolerance and shown that the prepared compounds could eradicate several medically important pathogens (P. aeruginosa, E. coli, and S. aureus). Importantly, as these compounds are hybrids of drugs that are already used clinically as stand-alone therapies, they demonstrate great potential to be translated into therapies in the near future.
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Padhee, Shruti. "Insights into [aacute]-AA peptides and ã-AA peptides as broad spectrum antimicrobial peptidomimetics and as anti-biofilm agents." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5091.

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The emergent resistance of bacteria against the conventional antibiotics has motivated the search for novel antimicrobial agents. Nature abounds with a number of antimicrobial peptides that are a part of our innate immune system and protect us against a variety of pathogenic bacteria. While they are broad-spectrum in their activity and show less drug-resistance induction, their intrinsic metabolic stability limits their potential therapeutic applications. Herein we describe the development of novel broad-spectrum bioactive antimicrobial peptidomimetics AA-peptides. AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two types of AApeptides are discussed in this dissertation "[aacute]-AApeptides" and " ã-AApeptides" The therapeutic potential of these AApeptides were accessed by conducting antibacterial assays against a series of both gram-positive, gram-negative bacteria and fungi. These oligomers were characterized using MALDI-TOF and Circular Dichroism spectroscopy (CD). Their invitro toxicity was evaluated against human erythrocytes .We attempted to study their mechanism of action via membrane depolarization assay. We have successfully identified them as antimicrobial agents, pro-inflammatory immune response suppressing agents and as anti-biofilm agents.
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Leite, Vanessa Maria Fagundes. "Estudo in vitro e in vivo de dentifrícios experimentais à base de Ricinus communis (éster do ácido ricinoléico), Triclosan e Cloramina-T para higiene de próteses totais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/58/58131/tde-23062015-093426/.

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Foram avaliados dentifrícios experimentais à base de Ricinus communis (DR), Triclosan (DT) e Cloramina-T (DC) para higiene de próteses totais, tendo como controle dentifrício sem agente antimicrobiano (DB) e água. Para análise in vitro foram realizados ensaios físico-químicos (medida da densidade, pH, consistência e características reológicas); ensaio de abrasividade, avaliada em 30 espécimes de resina acrílica antes e após a escovação artificial e análise microbiológica com a formação de biofilme multiespécies (S. mutans, C. albicans e C. glabrata) sobre espécimes em resina acrílica. Estes, após contaminação, foram escovados por 60s com DR, DT, DC e DB e água (n=10). Foram empregados controles positivo (contaminado e não escovado) e negativo (sem contaminação). Para análise in vivo, seguiu-se o modelo \"crossover\" com \"washout\" de 7 dias. Os voluntários escovaram suas próteses superiores 3 vezes ao dia por 07 dias. A capacidade de remoção do biofilme foi avaliada empregando evidenciação, fotografia e quantificação com software Image Tool 3.0. Na avaliação antimicrobiana, o biofilme foi desprendido da prótese por escovação com solução salina e a suspensão resultante, semeada em meios de cultura específicos para Candida spp, S. mutans, S. aureus e bactérias Gram-negativas. As espécies de Candida foram identificadas pelo meio de cultura Chromagar e pela PCR (Polymerase Chain Reaction). Na avaliação dos dentifrícios pelos participantes foi aplicado questionário. Os resultados das características organolépticas e físico-químicas foram informados em tabelas autoexplicativas. Os dados de rugosidade foram analisados por ANOVA e os dados da ação antimicrobiana in vitro, pelo teste de Kruskal-Wallis. Para os dados das variáveis clínicas (in vivo), empregou-se teste de Friedman e o teste de Cochran. Os testes estatísticos foram realizados com p<0,05. Os dentifrícios não apresentaram diferença quanto à abrasividade (DB=0,264±0,098; DR=0,236±0,236; DT=0,265±0,116; DC=0,203±0,105), porém promoveram aumento da rugosidade comparando à água (0,027±0,004). Frente às espécies de Candida, in vitro, o DT foi o mais eficaz (p=0,00; m=1,30) seguido do DC (m=2,6), DB (m=3,26) e DR (m=3,59). Para o S. mutans houve diferença entre a água (m=3,86) e os dentifrícios (p=0,001), porém não entre estes (DB: m=0; DR: m=2,3 e DC: m=0). DT inibiu o crescimento de S. mutans. Quanto à capacidade de remoção do biofilme, não houve diferença entre os dentifrícios (p=0,055; DB: m=7,39; DR: m=7,94; DT: m=10,16; DC: m=8,14), porém houve redução do biofilme comparando ao Baseline (m=16,53). Os dentifrícios não apresentaram diferença antimicrobiana, in vivo, contra Candida spp. (p=0,495), S. mutans (p=0,497), S. aureus (p=0,845) e bactérias Gram-negativas (p=0,425). Na identificação das espécies de Candida pelo Chromagar não houve diferença quanto ao seu aparecimento independente do dentifrício (p=0,466). O resultado pela PCR foi semelhante à identificação convencional e as espécies de C. albicans, C. tropicalis e C. glabrata foram mais prevalentes, respectivamente. Na avaliação dos dentifrícios pelos participantes não houve diferença (p>0,05) entre eles para nenhuma questão. Os dentifrícios apresentaram resultados satisfatórios, apresentando potencial para uso clínico e controle do biofilme de próteses totais.
This study evaluated experimental dentifrices based on Ricinus communis (DR), Triclosan (DT) and Cloramina-T (DC) for complete denture cleaning. To in vitro analysis were performed physicochemical tests (measurement of density, pH, consistency and rheological characteristics); abrasiveness test evaluated in 30 acrylic resin specimens before and after artificial brushing and microbiological analysis with multi-species biofilm formation (Streptococcus mutans, C. albicans and C. glabrata) on the specimens of acrylic resin. This specimens were manually brushed for 60 seconds with DR, DT, DC and DB and water (n = 10). Positive controls were used (contaminated and not brushed) and negative (no contamination). To in vivo analysis the study followed the crossover model with washout of 7 days. The volunteers brushed their upper dentures 3 times daily for 07 days. The removal of biofilm capacity was evaluated employing evidenciation, photography and quantification with Image Tool 3.0 software. For the evaluation of antimicrobial activity, the biofilm was removed from the denture by brushing with saline solution and the suspension was seeded in culture media specific for Candida spp, S. mutans, S. aureus and Gram-negative bacteria. The Candida species were identified by culture medium Chromagar and PCR method (Polymerase Chain Reaction). One questionnaire was used for the dentifrices evaluation by the participants. The results of physicochemical characteristics were informed in self-explanatory tables. The roughness data were analyzed by ANOVA and antimicrobial activity in vitro data by the Kruskal-Wallis test. To the data of the clinical variables (in vivo) was used Friedman test and Cochran test. Statistical tests were performed with p<0.05. The dentifrices showed no difference in the abrasiveness (DB=0.264 ± 0.098, DR=0.236 ± 0.236, DT=0.265 ± 0.116, DC=0.203 ± 0.105), but promoted increased roughness when compared to water (0.027 ± 0.004). To Candida species, in vitro, the DT was the most effective (p=0.00, m=1.30) followed by DC (m=2.6), DB (m=3.26) and DR (m=3.59). To S. mutans there was difference between the water (m=3.86) and dentifrices (p=0.001), but these did not showed difference from each other (DB: m=0; DR: m=2.3 and DC: m=0). DT inhibited the growth of S. mutans. There was no difference among the dentifrices for biofilm removal (p=0.055; DB: m=7.39; DR: m=7.94; DT: m=10.16; DC: m=8.14), but the biofilm decreased when compared to Baseline (m=16.53). The dentifrices showed no difference antimicrobial, in vivo, against Candida spp. (p=0.495), S. mutans (p=0.497), S. aureus (p=0.845) and Gram-negative bacteria (p=0.425). In the identification of Candida species by Chromagar there was no difference in the appearance of their independent dentifrices (p=0.466). The result by PCR was similar conventional identification, and the species of C. albicans, C. tropicalis and C. glabrata were more prevalent, respectively. In the evaluation of dentifrices by the participants there was no difference (p>0.05) among them to any question. The dentifrices showed satisfactory results with potential for its specificity.
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DE, ARPAN. "Streptococcus mutans X-prolyl dipeptidyl peptidase as a target against biofilm formation unravelled by antihuman DPP IV drugs: a new paradigm for the synthesis of innovative anti-caries agents." Doctoral thesis, Università degli Studi di Camerino, 2015. http://hdl.handle.net/11581/401720.

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Machado, Juliana de Carvalho [UNESP]. "Efeito da combinação de antibióticos e sinvastatina sobre microrganismos de interesse endodôntico e na expressão de marcadores odontoblásticos." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138844.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Terapias biológicas tem buscado novas substâncias/protocolos que promovam a eliminação microbiana e induzam ou estimulem a regeneração pulpar e o desenvolvimento completo radicular de dentes permanentes jovens com processos patológicos pulpares. Os objetivos do estudo foram avaliar a a tividade antimicrobiana/antibiofilme de algumas combinações de antibióticos sobre microrganismos de interesse endodôntico e analisar o efeito da combinação de antibióticos com melhor ação antimicrobiana associada à sinvastatina na expressão de marcadores odontoblásticos em células da polpa dental humana (CPDH). A atividade antimicrobiana dos seguintes antibióticos : Metronidazol (ME), Ciprofloxacina (CI), Minociclina (MI), Doxicilina (DO) e Fosfomicina (FO), isolados ou em combinação dupla (ME+CI, ME+MI, ME+DO, ME+FO, CI+MI, CI+DO, CI+FO, DO+FO, MI+FO) ou tripla (ME+CI+MI, ME+CI+FO, ME+MI+FO, ME+CI+DO, ME+DO+FO, CI+DO+FO, CI+MI+FO) foram testados contra Streptococcus mutans, Enterococcus faecalis, Actinomyces israelii e Candida albicans em condições planctônicas. Biofilmes mono-espécie de E. faecalis e biofilmes em dual-espécies de E. faecalis and C. albicans foram preparados em blocos de dentina para testar a atividade antibiofilme das combinações de antibióticos com os melhores resultados microbiológicos. O efeito antibiofilme das combinações antibióticas sobre biofilme de E. faecalis dentro dos túbulos dentinários foi também avaliada por microscopia confocal. Culturas de CPDH foram expostas à combinação antibiótica com melhor resultado microbiológico e sinvastatina e determinada a viabilidade celular, atividade da fosfatase alcalina (ALP), deposição de nódulos de mineralização e expressão de DSPP (sialofosfoproteína dentinária), importante marcador odontoblástico de mineralização denti nária. Os dados foram 9 analisados estatisticamente, considerando p<0,05 . Todas as combinações de antibióticos reduziram o crescimento bacteriano, exceto por CI+DO e DO+FO para A. Israelii. ME+CI+MI e ME+MI+FO inibiram significantemente o crescimento de A. israelii e E. faecalis, e ME+MI+FO eliminou S. mutans. ME+MI+FO e ME+CI+FO tiveram o melhor efeito contra biofilme de E. faecalis, em mono ou dual-espécies e dentro dos túbulos dentinários. CI e ME+CI+FO afetaram a viabilidade das células pulpares, em 1 e 7 dias. A atividade de ALP aumentou com a presença de sinvastatina para todos os grupos, exceto para CI e ME+CI+FO. Grupos contendo sinvastatina mostram maior deposição de nódulos de mineralização e expressão de DSPP que os grupos sem sinvastatina. Pode-se concluir que a combinação de antibióticos tripla ME+CI+FO teve efeito marcante contra os microrganismos endodônticos, em condições planctônicas e em biofilme. A sinvastatina estimulou a expressão de marcadores odontoblásti cos de mineralização dentinária pelas HDPC; entretanto, seu efeito foi reduzido pela presença da CI.
Biological therapies have searching for substances/protocols, which promote microbial elimination and induce or stimulate pulp regeneration and completion of apical root development in young permanent teeth with pulp pathological processes . The objectives of this study were to evaluate the antimicrobial /anti-biofilm activity of some antibiotics combinations on endodontic microorganisms and the effect of the combination of antibiotics with the best antimicrobial action associated with simvastatin on expression of odontoblast markers by human dental pulp cells (HDPC). The antimicrobial activity of the following antibiotics : Metronidazole (ME), Ciprofloxacin (CI), Minocycline (MI), Doxycycline (DO) and Fosfomycin (FO), either alone or in double (ME+CI, ME+MI, ME+DO, ME+FO, CI+MI, CI+DO, CI+FO, DO+FO, MI+FO) or triple combinations (ME+CI+MI, ME+CI+FO, ME+MI+FO, ME+CI+DO, ME+DO+FO, CI+DO+FO, CI+MI+FO) were tested against Streptococcus mutans, Enterococcus faecalis, Actinomyces israelii and Candida albicans in planktonic conditions. Mono-species biofilm of E. faecalis and dual-species biofilms of E. faecalis and C. albicans were prepared in dentin blocks to test the anti -biofilm activity of antibiotic combinations with the best microbiological results. Antibiofilm effect of antibiotic combination on E. faecalis biofilm inside dentin tubules was also evaluated by confocal microscopy. Cultures of HDPC were exposed to the antibiotic combination with the best antimicrobial effect and simvastatin and determined cell viability, alkaline phosphatase activity, deposition of mineralization nodules and expression of Dspp (dentin sialophosphoprotein), important odontoblast markers of dentin mineralization. Data were analyzed statistically, considering p<0.05. All antibiotic combinations reduced statistically the growth of bacteria tested, except by CI+DO and DO+FO for A. israelii. ME+CI+MI and ME+MI+FO inhibited significantly growth of A. 11 israelii and E. faecalis, and ME+MI+FO eliminated S. mutans. ME+MI+FO and ME+CI+FO had the best effect against E. faecalis biofilm, in mono and dual -species biofilms and inside dentin tubules, similar to CHX. CI and ME+CI+FO affected HDPC viability, 1 and 7 days. ALP activity increased with the presence of simvastatin for all groups, except by CI and ME+CI+FO. Groups containing simvastatin had higher mineralized nodule deposition and higher DSPP expression than groups without simvastatin. It can be concluded that triple antibiotic combination of ME+CI+FO ha d remarkable effect against endodontic microorganisms, in planktonic and biofilm conditions. Simvastatin stimulated the expression of odontoblast markers of dentin mineralization by HDPC; however, its effect was reduced i n the presence of CI.
FAPESP: 2014/00589-7
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LI, PETRI Giovanna. "SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS ANTICANCER AND ANTIBIOFILM AGENTS, AND PRECLINICAL INVESTIGATION OF ANTI-LDH-A COMPOUNDS AGAINST MALIGNANT MESOTHELIOMA." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395253.

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Chorell, Erik. "Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37161.

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New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. Pilicides are a class of compounds based on a ring-fused 2-pyridone scaffold that target bacterial virulence by blocking the chaperone/usher pathway in E. coli and thereby inhibit the assembly of pili. This thesis describes the design, synthesis, and biological evaluation of compounds based on the pilicide scaffold with the goal of improving the pilicides and expanding their utility. Synthetic pathways have been developed to enable the introduction of substituents at the C-2 position of the pilicide scaffold. Biological evaluation of these compounds demonstrated that some C-2 substituents give rise to significant increases in potency. X-ray crystallography was used to elucidate the structural basis of this improved biological activity. Furthermore, improved methods for the preparation of oxygen-analogues and C-7 substituted derivatives of the pilicide scaffold have been developed. These new methods were used in combination with existing strategies to decorate the pilicide scaffold as part of a multivariate design approach to improve the pilicides and generate structure activity relationships (SARs). Fluorescent pilicides were prepared using a strategy where selected substituents were replaced with fluorophores having similar physicochemical properties as the original substituents. Many of the synthesized fluorescent compounds displayed potent pilicide activities and can thus be used to study the complex interactions between pilicide and bacteria. For example, when E. coli was treated with fluorescent pilicides, it was found that the compounds were not uniformly distributed throughout the bacterial population, suggesting that the compounds are primarily associated to bacteria with specific properties. Finally, by studying compounds designed to inhibit the aggregation of Aβ, it was found that some compounds based on the pilicide scaffold inhibit the formation of the functional bacterial amyloid fibers known as curli; these compounds are referred to as 'curlicides'. Some of the curlicides also prevent the formation of pili and thus exhibit dual pilicide-curlicide activity. The potential utility of such 'dual-action' compounds was highlighted by a study of one of the more potent dual pilicide-curlicides in a murine UTI model were the compound was found to significantly attenuate virulence in vivo.
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SCIANO', Fabio. "Development of natural and synthetic compounds as kinase inhibitors targeting cancer cells and cancer stem cells." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580156.

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Gheffar, Chahrazed. "Nanoparticules de PLGA chargées en ciproflaxine : élaboration, caractérisation, activité antibactérienne en modes planctonique et biofilm." Rouen, 2016. http://www.theses.fr/2016ROUES009.

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L’adhésion de bactéries et par suite la formation de biofilms sur la surface de matériaux sont des problèmes récurrents qui peuvent avoir de graves conséquences aussi bien dans le domaine de la santé qu’au niveau industriel. L’éradication des biofilms demeure aujourd’hui un véritable défi et une stratégie proposée consiste en la vectorisation d’agents biocides à l’aide de nanoparticules polymères. La présente étude rapporte l’élaboration de nanoparticules (NPs) biodégradables et biocompatibles de poly(acide lactique-co-glycolique) (PLGA) par le procédé de nanoprécipitation. Les NPs ont aussi été pégylées afin de moduler leur interaction avec les milieux biologiques. Les particules ont été chargées en ciprofloxacine (CIP) avec un taux de charge d’environ 5 %, ce qui permet une libération progressive de la CIP sur 5-6 jours. Des essais microbiologiques ont été réalisés sur la bactérie Gram positif Staphylococcus aureus. Cette bactérie est l’une des principales causes d’infections chroniques et nosocomiales, impliquant le plus souvent des biofilms. Les NPs de PLGA nues et pégylées ont montré une activité antibactérienne en mode planctonique sur deux souches de S. Aureus (ATCC 29213 et 610520), sans doute liée à un effet de taille (échelle nanométrique). Ces NPs n’ont pas montré de cytotoxicité in vitro sur des cellules neuronales. Enfin, des études microbiologiques sur les NPs chargées en CIP ont été menées sur une souche de S. Aureus (ATCC 29213) en modes planctonique et biofilm. La CIP encapsulée reste efficace après séquestration et s’avère plus active pour éradiquer le biofilm que la CIP libre (diminution de la concentration minimale d’éradication du biofilm)
The adhesion of bacteria and hence formation of biofilms on the surface of materials are recurring problems that can have serious consequences at both public health and industrial level. The eradication of biofilms today remains a challenge and a proposed strategy is the vectorization of biocidal agents by using polymeric nanoparticles. This study reports the elaboration of biocompatible and biodegradable nanoparticles (NPs) based on poly(lactic-co-glycolic acid) (PLGA) by the nanoprecipitation method. The nanoparticles were also pegylated in order to modulate their interaction with the biological media. The particles were loaded with ciprofloxacin (CIP) with a drug content of about 5 %, which allows a gradual release of the CIP during 5-6 days. Microbiological tests were made against gram positive bacteria Staphylococcus aureus. This bacteria is one of the major causes of chronic and nosocomial infections, most often involving biofilms. The naked NPs and the pegylated ones exhibited an antibacterial activity on planktonic cells against two strains of S. Aureus (ATCC 29213 and 610520), probably related to a size effect (nanoscale). These NPs showed no cytotoxicity in vitro on neuronal cells. Finally, the antibacterial activity studies of NPs loaded with CIP were conducted against a S. Aureus (ATCC 29213) on planktonic cells and biofilm. Encapsulated CIP remains effective after sequestration and is more active to eradicate biofilm than free CIP (decrease of the minimum biofilm eradication concentration)
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Books on the topic "Anti-biofilm agents"

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Biofilm eradication and prevention: A pharmaceutical approach to medical device infections. Hoboken, N.J: Wiley, 2010.

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Shunmugaperumal, Tamilvanan. Biofilm eradication and prevention: A pharmaceutical approach to medical device infections. Hoboken, N.J: Wiley, 2010.

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Biofilm Control and Antimicrobial Agents. Apple Academic Press, Incorporated, 2014.

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Sayen, S. M. Abu. Biofilm Control and Antimicrobial Agents. Taylor & Francis Group, 2014.

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Sayen, S. M. Abu. Biofilm Control and Antimicrobial Agents. Taylor & Francis Group, 2021.

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Shunmugaperumal, Tamilvanan. Biofilm Eradication and Prevention. Wiley & Sons, Incorporated, John, 2010.

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Shunmugaperumal, Tamilvanan. Biofilm Eradication and Prevention: A Pharmaceutical Approach to Medical Device Infections. Wiley & Sons, Incorporated, John, 2011.

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Shunmugaperumal, Tamilvanan. Biofilm Eradication and Prevention: A Pharmaceutical Approach to Medical Device Infections. Wiley & Sons, Incorporated, John, 2010.

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Shunmugaperumal, Tamilvanan. Biofilm Eradication and Prevention: A Pharmaceutical Approach to Medical Device Infections. Wiley & Sons, Incorporated, John, 2010.

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Shunmugaperumal, Tamilvanan. Biofilm Eradication and Prevention: A Pharmaceutical Approach to Medical Device Infections. Wiley & Sons, Incorporated, John, 2010.

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Book chapters on the topic "Anti-biofilm agents"

1

Săndulescu, Oana, and Mihai Săndulescu. "Anti-biofilm Agents." In Biofilm, Pilonidal Cysts and Sinuses, 27–54. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/15695_2017_4.

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Ahmad, K., M. H. Baig, Fohad Mabood Husain, Iqbal Ahmad, M. E. Khan, M. Oves, Inho Choi, and Nasser Abdulatif Al-Shabib. "Anti-QS/Anti-Biofilm Agents in Controlling Bacterial Disease: Anin silicoApproach." In Biofilms in Plant and Soil Health, 497–511. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119246329.ch25.

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Ahmed, Salman, and Rabih O. Darouiche. "Anti-biofilm Agents in Control of Device-Related Infections." In Advances in Experimental Medicine and Biology, 137–46. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09782-4_9.

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Holmström, Carola, Peter Steinberg, and Staffan Kjelleberg. "Bioprospecting Novel Antifoulants and Anti-Biofilm Agents from Microbes." In Microbial Diversity and Bioprospecting, 405–12. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817770.ch36.

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Shahrour, Hawraa, Raquel Ferrer-Espada, Israa Dandache, Sergio Bárcena-Varela, Susana Sánchez-Gómez, Ali Chokr, and Guillermo Martinez-de-Tejada. "AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis." In Advances in Experimental Medicine and Biology, 257–79. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3588-4_14.

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Sandala, Jenna, and John S. Gunn. "In Vitro Evaluation of Anti-biofilm Agents Against Salmonella enterica." In Methods in Molecular Biology, 127–39. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0791-6_12.

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Rajput, Akanksha, Kailash T. Bhamare, Adhip Mukhopadhyay, Amber Rastogi, Sakshi, and Manoj Kumar. "Efficacy of Anti-Biofilm Agents in Targeting ESKAPE Pathogens with a Focus on Antibiotic Drug Resistance." In ACS Symposium Series, 177–99. Washington, DC: American Chemical Society, 2020. http://dx.doi.org/10.1021/bk-2020-1374.ch010.

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Lahiri, Dibyajit, Moupriya Nag, Bandita Dutta, Sudipta Dash, Shreyasi Ghosh, and Rina Rani Ray. "Synergistic Effect of Quercetin with Allicin from the Ethanolic Extract of Allium cepa as a Potent AntiQuorum Sensing and Anti-Biofilm Agent Against Oral Biofilm." In Lecture Notes in Bioengineering, 69–81. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7409-2_7.

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Riool, Martijn, and Sebastian A. J. Zaat. "Biomaterial-Associated Infection: Pathogenesis and Prevention." In Urinary Stents, 245–57. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04484-7_20.

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AbstractThe use of medical devices, such as urinary stents, catheters, artificial heart valves, prosthetic joints and other implants, collectively often referred to as “biomaterials” has increased dramatically over the past century, and has become a major part of modern medicine and our daily life. With the aging society, the higher demand on these devices to restore function and quality of life, combined with the ever improving technology within the medical field, the problem of biomaterial-associated infection (BAI) is expected to increase.The most common causative microorganisms in BAI are Staphylococcus aureus, a major pathogen in wound infections, and Staphylococcus epidermidis, the harmless skin commensal. Depending on the type of device and location of application, other pathogens such as coagulase-negative staphylococci, enterococci, streptococci, Propionibacterium acnes and yeast can also cause BAI.Prevention of BAI is a challenging problem, in particular due to the increased risk of resistance development associated with current antibiotic-based strategies. Here we showed the evidence of biofilms as a source for peri-implant tissue colonization, clearly showing the importance of preventive measures to be able to act both against implant and tissue colonization. Subsequently, we described different strategies to prevent BAI and other difficult-to-treat biofilm infections. We conclude that future research should focus on the development of combination devices with both anti-fouling or contact-killing capacities—to protect the implant—and controlled release of an antimicrobial agent to protect the surrounding tissue.
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Duah Boakye, Yaw, Newman Osafo, Cynthia Amaning Danquah, Francis Adu, and Christian Agyare. "Antimicrobial Agents: Antibacterial Agents, Anti-biofilm Agents, Antibacterial Natural Compounds, and Antibacterial Chemicals." In Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.82560.

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Reports on the topic "Anti-biofilm agents"

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed at detecting BCAs and associated biologically-active compounds, which included: (A) isolation of multidrug-resistant desert soil bacteria and root-associated bacteria from medicinal plants; (B) invitro screening of bacterial isolates against known plant, animal and human pathogens; (C) nextgeneration sequencing of isolates that displayed antagonistic activity against at least one of the model pathogens and (D) in-planta screening of promising BCAs in a model bean-Sclerotiumrolfsii system. The BCA genome data were examined for presence of: i) secondary metabolite encoding genes potentially linked to the anti-pathogenic activity of the isolates; and ii) rhizosphere competence-associated genes, associated with the capacity of microorganisms to successfully inhabit plant roots, and a prerequisite for the success of a soil amended BCA. Altogether, 56 phylogenetically-diverse isolates with bioactivity against bacterial, oomycete and fungal plant pathogens were identified. These strains were sent to Auburn University where bioassays against a panel of animal and human pathogens (including multi-drug resistant pathogenic strains such as A. baumannii 3806) were conducted. Nineteen isolates that showed substantial antagonistic activity against at least one of the screened pathogens were sequenced, assembled and subjected to bioinformatics analyses aimed at identifying secondary metabolite-encoding and rhizosphere competence-associated genes. The genome size of the bacteria ranged from 3.77 to 9.85 Mbp. All of the genomes were characterized by a plethora of secondary metabolite encoding genes including non-ribosomal peptide synthase, polyketidesynthases, lantipeptides, bacteriocins, terpenes and siderophores. While some of these genes were highly similar to documented genes, many were unique and therefore may encode for novel antagonistic compounds. Comparative genomic analysis of root-associated isolates with similar strains not isolated from root environments revealed genes encoding for several rhizospherecompetence- associated traits including urea utilization, chitin degradation, plant cell polymerdegradation, biofilm formation, mechanisms for iron, phosphorus and sulfur acquisition and antibiotic resistance. Our labs are currently writing a continuation of this feasibility study that proposes a unique pipeline for the detection of BCAs and biopesticides that can be used against phytopathogens. It will combine i) metabolomic screening of strains from our collection that contain unique secondary metabolite-encoding genes, in order to isolate novel antimicrobial compounds; ii) model plant-based experiments to assess the antagonistic capacities of selected BCAs toward selected phytopathogens; and iii) an innovative next-generation-sequencing based method to monitor the relative abundance and distribution of selected BCAs in field experiments in order to assess their persistence in natural agro-environments. We believe that this integrated approach will enable development of novel strains and compounds that can be used in large-scale operations.
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