Journal articles: 'Anti adhesive agent'

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TAKEUCHI, Toshiya. "History and Future of Anti-Adhesive Agent." NIPPON GOMU KYOKAISHI 93, no. 6 (2020): 190–94. http://dx.doi.org/10.2324/gomu.93.190.

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Emanuele, R. Martin. "FLOCOR™: a new anti-adhesive, rheologic agent." Expert Opinion on Investigational Drugs 7, no. 7 (July 1998): 1193–200. http://dx.doi.org/10.1517/13543784.7.7.1193.

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Hassan, Nisreen, Mushir Ali, and Javed Ali. "Novel buccal adhesive system for anti-hypertensive agent Nimodipine." Pharmaceutical Development and Technology 15, no. 2 (November 13, 2009): 124–30. http://dx.doi.org/10.3109/10837450903055494.

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Gutsaeva, Diana R., James B. Parkerson, Shobha D. Yerigenahally, Jeffrey C. Kurz, Robert G. Schaub, Tohru Ikuta, and C. Alvin Head. "Inhibition of cell adhesion by anti–P-selectin aptamer: a new potential therapeutic agent for sickle cell disease." Blood 117, no. 2 (January 13, 2011): 727–35. http://dx.doi.org/10.1182/blood-2010-05-285718.

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Abstract Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti–P-selectin aptamer and examined its effects on cell adhesion using knockout-transgenic SCD model mice. Aptamers, single-stranded oligonucleotides that bind molecular targets with high affinity and specificity, are emerging as new therapeutics for cardiovascular and hematologic disorders. In vitro studies found that the anti–P-selectin aptamer exhibits high specificity to mouse P-selectin but not other selectins. SCD mice were injected with the anti–P-selectin aptamer, and cell adhesion was observed under hypoxia. The anti–P-selectin aptamer inhibited the adhesion of sickle RBCs and leukocytes to endothelial cells by 90% and 80%, respectively. The anti–P-selectin aptamer also increased microvascular flow velocities and reduced the leukocyte rolling flux. SCD mice treated with the anti–P-selectin aptamer demonstrated a reduced mortality rate associated with the experimental procedures compared with control mice. These results demonstrate that anti–P-selectin aptamer efficiently inhibits the adhesion of both sickle RBCs and leukocytes to endothelial cells in SCD model mice, suggesting a critical role for P-selectin in cell adhesion. Anti–P-selectin aptamer may be useful as a novel therapeutic agent for SCD.

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Zhong, Jian Hua, Zhi Hong Li, and Ling Yu Ouyang. "Study on the Anti-Oxidant Property of Copper Powder Coated Silane Coupling Agent in Isotropically Conductive Adhesives." Advanced Materials Research 139-141 (October 2010): 117–20. http://dx.doi.org/10.4028/www.scientific.net/amr.139-141.117.

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In this experiment, the micro copper powders with high temperature of oxidation resistance were prepared by coating with 2 wt.% of silane coupling agent(KH560) solution in order to protect them from oxidation in isotropically conductive adhesives, and X-ray diffraction analysis(XRD), thermo gravimetric analysis(TGA) and accelerated aging test were applied to analyze the anti-oxidant property of the samples before and after they were treated. Experimental results showed that the polymer of silane coupling agent on the surfaces of copper powders had high thermal stability exposed under high temperature and was very effective in preventing the copper powders from oxidation in isotropically conductive adhesives. Besides, the epoxy conductive adhesive sample with plated copper as electrically conductive fillers still had good conductive property even exposed at 160 degrees with its bulk resistivity was 8.75×10-3Ω•cm.

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KAWAHARA, Kazuki, Hiroya OKI, and Shota NAKAMURA. "Structural Study of Bacterial Pili for Development of the Anti-Adhesive Agent." Nihon Kessho Gakkaishi 62, no. 3 (August 31, 2020): 139–40. http://dx.doi.org/10.5940/jcrsj.62.139.

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Allegrone, Gianna, Chiara Ceresa, Maurizio Rinaldi, and Letizia Fracchia. "Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm." Pharmaceutics 13, no. 8 (July 29, 2021): 1172. http://dx.doi.org/10.3390/pharmaceutics13081172.

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A major challenge in the biomedical field is the creation of materials and coating strategies that effectively limit the onset of biofilm-associated infections on medical devices. Biosurfactants are well known and appreciated for their antimicrobial/anti-adhesive/anti-biofilm properties, low toxicity, and biocompatibility. In this study, the rhamnolipid produced by Pseudomonas aeruginosa 89 (R89BS) was characterized by HPLC-MS/MS and its ability to modify cell surface hydrophobicity and membrane permeability as well as its antimicrobial, anti-adhesive, and anti-biofilm activity against Staphylococcus aureus were compared to two commonly used surfactants of synthetic origin: Tween® 80 and TritonTM X-100. The R89BS crude extract showed a grade of purity of 91.4% and was composed by 70.6% of mono-rhamnolipids and 20.8% of di-rhamnolipids. The biological activities of R89BS towards S. aureus were higher than those of the two synthetic surfactants. In particular, the anti-adhesive and anti-biofilm properties of R89BS and of its purified mono- and di-congeners were similar. R89BS inhibition of S. aureus adhesion and biofilm formation was ~97% and 85%, respectively, and resulted in an increased inhibition of about 33% after 6 h and of about 39% after 72 h when compared to their chemical counterparts. These results suggest a possible applicability of R89BS as a protective coating agent to limit implant colonization.

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Kharouf, Naji, Ammar Eid, Louis Hardan, Rim Bourgi, Youri Arntz, Hamdi Jmal, Federico Foschi, et al. "Antibacterial and Bonding Properties of Universal Adhesive Dental Polymers Doped with Pyrogallol." Polymers 13, no. 10 (May 11, 2021): 1538. http://dx.doi.org/10.3390/polym13101538.

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This study investigated the antibacterial activity, bond strength to dentin (SBS), and ultra-morphology of the polymer–dentin interface of experimental adhesive systems doped with pyrogallol (PY), which is a ubiquitous phenolic moiety that is present in flavonoids and polyphenols. A universal adhesive containing 4-META and 10-MDP was used in this study. PY behaves as an antioxidant and anti-cancerogenic agent and it was incorporated into the adhesive at different concentrations (0.5 and 1 wt.%). The antibacterial activity and SBS were analyzed and the results were statistically analyzed. The ultra-morphology of the polymer–dentin interface was assessed using scanning electron microscopy (SEM). At 24 h, a lower antibacterial activity was observed for the control adhesive compared to those with 0.5% and 1% PY. No difference was seen in SBS between the three groups at 24 h. After 6 months, the SBS of the 0.5% PY adhesive was significantly lower than the other tested adhesives. The specimens created with 1% PY adhesive presented a higher bond strength at six months compared with that found at 24 h. No morphological differences were found at the polymer–dentin interfaces of the tested adhesives. Pyrogallol may be incorporated into modern universal adhesive systems to preserve the polymer–dentin bonding interface and confer a certain degree of antibacterial activity.

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Kim, Kwang-Il, Ha-Na Na, Yoshihiro Ito, and Tae-Il Son. "Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent." Macromolecular Research 19, no. 3 (March 2011): 216–20. http://dx.doi.org/10.1007/s13233-011-0303-4.

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Zhang, De Cheng, Dong Yu Xu, and Xin Cheng. "Research on High Performance Sulfoaluminate Cement Underwater Non-Dispersed Concrete." Advanced Materials Research 306-307 (August 2011): 956–60. http://dx.doi.org/10.4028/www.scientific.net/amr.306-307.956.

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Sulfoaluminate cement, non-ionic polyacrylamide and sulfamate high-effective water reducing agent were used as main raw materials to fabricate concrete. The adhesive performance of high performance sulfoaluminate cement underwater non-dispersed concrete and its influence on water quality in surrounding water areas were studied. The compressive strength ratio of concrete cast in water and in air was also determined. The results show that mortar and concrete using non-ionic polyacrylamide as adhesion agent has many advantages such as superior underwater anti-washout properties, little pollution to water quality in the surrounding water areas and obvious early strength. Furthermore, the compressive strength ratio of concrete cast in water and in air is also up to the required standard.

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Park, Jeong Woo, Koang Hum Bak, Tae Koo Cho, Hyoung-Joon Chun, and Je Il Ryu. "Effects of a Temperature-Sensitive, Anti-Adhesive Agent on the Reduction of Adhesion in a Rabbit Laminectomy Model." Journal of Korean Neurosurgical Society 59, no. 3 (2016): 250. http://dx.doi.org/10.3340/jkns.2016.59.3.250.

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Zhang, Guohong, Jianhui Qiu, Jingzhuo Zhao, Dingbang Wei, and Hui Wang. "Development of Interfacial Adhesive Property by Novel Anti-Stripping Composite between Acidic Aggregate and Asphalt." Polymers 12, no. 2 (February 19, 2020): 473. http://dx.doi.org/10.3390/polym12020473.

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Studies on control of and preventive measures against asphalt pavement moisture damage have important economic and social significance due to the multiple damage and repair of pavements, the reasons for which include the poor interfacial adhesive ability between acidic aggregates and asphalts. Anti-stripping agent is used in order to improve the poor adhesion, and decomposition temperature is regarded as being important for lots of anti-stripping products, because they always decompose and lose their abilities under the high temperature in the mixing plant before application to the pavement. A novel anti-stripping composite, montmorillonoid/Polyamide (OMMT/PAR), which possesses excellent thermal stability performance and is effective in preventing moisture damage, especially for acidic aggregates, was prepared. Moreover, the modification mechanisms and pavement properties were also investigated with reference to the composites. The results show that OMMT/PAR was prepared successfully, improving the interfacial adhesion between the acidic aggregate and the modified asphalt. Due to the nanostructure of OMMT/PAR, the thermal stability was enhanced dramatically and the interfacial adhesion properties were also improved. Furthermore, asphalts modified with OMMT/PAR and their mixtures showed excellent properties. Finally, the moisture damage process and the mechanisms by which OMMT/PAR improves the interfacial adhesion properties are explained through adhesion mechanism analyses.

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Dinarvand, Peyman, and Alireza R. Rezaie. "Intraperitoneal Administration Of Activated Protein C Prevents Post-Surgical Adhesion Band Formation." Blood 122, no. 21 (November 15, 2013): 3581. http://dx.doi.org/10.1182/blood.v122.21.3581.3581.

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Abstract Postoperative intraperitoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain and female infertility. Adhesion bands are induced by inflammatory responses elicited by injury following surgery. The objective of this study was to evaluate the effectiveness of activated protein C (APC), a natural anticoagulant and antiinflammatory serine protease in plasma, in preventing post-surgical intraperitoneal adhesion band formation. The protective effects of APC and the FDA approved agent, sodium hyaluronate/carboxymethylcellulose (HA/CMC, also called Seprafilm), were compared by administering the two drugs intraperitoneally into 30 male C57bl/6 mice. After 7 days, the pathological adhesion grades were scored by two scaling systems and the peritoneal fluid concentration of tissue plasminogen activator (tPA) as well as the concentrations of the proinflammatory cytokines, IL-1, IL-6, TNF-α, IFN-γ and TGF-β were evaluated. The inflammation scores of mice in all groups were also measured based on histological data obtained from peritoneal tissues. Relative to the HA/CMC group, intraperitoneal administration of APC led to a significantly higher reduction of adhesion band formation. Moreover, a markedly lower inflammation score was obtained in the adhesive tissues of the APC-treated group which correlated with significantly reduced peritoneal concentrations of IL-6, TNF-α, IFN-γ and TGF-β and elevated concentration of tPA in this group. These results suggest that in comparison to the FDA approved agent, Seprafilm, APC exhibits a markedly higher efficacy in preventing postoperative adhesion band formation. Thus, APC holds the potential to be therapeutically used as a novel anti-adhesive agent. Disclosures: No relevant conflicts of interest to declare.

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Labena, A., M. A. Hegazy, Radwa M. Sami, and Wael N. Hozzein. "Multiple Applications of a Novel Cationic Gemini Surfactant: Anti-Microbial, Anti-Biofilm, Biocide, Salinity Corrosion Inhibitor, and Biofilm Dispersion (Part II)." Molecules 25, no. 6 (March 16, 2020): 1348. http://dx.doi.org/10.3390/molecules25061348.

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The Egyptian petroleum industries are incurring severe problems with corrosion, particularly corrosion that is induced by sulfidogenic microbial activities in harsh salinity environments despite extensively using biocides and metal corrosion inhibitors. Therefore, in this study, a synthesized cationic gemini surfactant (SCGS) was tested as a broad-spectrum antimicrobial, anti-bacterial, anti-candida, anti-fungal, anti-biofilm (anti-adhesive), and bio-dispersion agent. The SCGS was evaluated as a biocide against environmental sulfidogenic-bacteria and as a corrosion inhibitor for a high salinity cultivated medium. The SCGS displayed wide spectrum antimicrobial activity with minimum bactericidal/fungicidal inhibitory concentrations. The SCGS demonstrated anti-bacterial, anti-biofilm, and bio-dispersion activity. The SCGS exhibited bactericidal activity against environmental sulfidogenic bacteria and the highest corrosion inhibition efficiency of 93.8% at 5 mM. Additionally, the SCGS demonstrated bio-dispersion activity against the environmental sulfidogenic bacteria at 5.49% salinity. In conclusion, this study provides a novel synthesized cationic surfactant with many applications in the oil and gas industry: as broad-spectrum antimicrobial and anti-biofilm agents, corrosion inhibition for high salinity, biocides for environmentally sulfidogenic bacteria, and as bio-dispersion agents.

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HICKEY, Michael J. "Role of inducible nitric oxide synthase in the regulation of leucocyte recruitment." Clinical Science 100, no. 1 (December 8, 2000): 1–12. http://dx.doi.org/10.1042/cs1000001.

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Constitutively produced nitric oxide released by endothelial cells has been shown to act as an endogenous agent which inhibits the rolling and adhesion of leucocytes in the microcirculation. However, during various types of inflammation, expression of the inducible form of nitric oxide synthase (iNOS) can dramatically increase the amount of nitric oxide present in tissues. Furthermore, as iNOS can be expressed by a wide variety of cell types, the distribution of nitric oxide is likely to be altered relative to that in unstimulated tissue. Under these conditions, it is less well understood whether iNOS-derived nitric oxide retains the anti-adhesive capabilities of constitutively produced nitric oxide. This review summarizes work done to examine this issue. Three main approaches have been used. In vitro studies have examined the role of iNOS in adhesive interactions between stimulated endothelial cells and leucocytes, providing evidence of an anti-adhesive effect of iNOS. In addition, the role of iNOS has been examined in vivo in animal models of inflammation using pharmacological iNOS inhibitors. These experiments were extended by the advent of the iNOS-deficient (iNOS-/-) mouse. Intravital microscopy studies of these mice have indicated that, under conditions of low-dose endotoxaemia, iNOS-derived nitric oxide can inhibit leucocyte rolling and adhesion. The potential mechanisms for these effects are discussed. In contrast, several other studies have observed either no effect or an enhancing effect of iNOS on inflammatory leucocyte recruitment. Taken together, these studies suggest that the importance of iNOS in modulating leucocyte recruitment can vary according to the type of inflammatory response.

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Chung, Pill Ku, Jae Chul Yoo, and Jeung Yeol Jeong. "Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study." Clinics in Shoulder and Elbow 20, no. 1 (March 31, 2017): 3–9. http://dx.doi.org/10.5397/cise.2017.20.1.3.

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Jang, Suk Yoon, Han Koo Kim, Woo Seob Kim, and Tae Hui Bae. "Correction of Cicatricial Upper Eyelid Ectropion Using a Dermofat Graft and an Anti-Adhesive Agent." Archives of Aesthetic Plastic Surgery 24, no. 1 (2018): 39. http://dx.doi.org/10.14730/aaps.2018.24.1.39.

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Kubes, Paul, Derrice Payne, and Richard C. Woodman. "Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation." American Journal of Physiology-Gastrointestinal and Liver Physiology 283, no. 1 (July 1, 2002): G139—G147. http://dx.doi.org/10.1152/ajpgi.00058.2002.

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Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia-reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti-selectin therapy (fucoidan) or anti-adhesion therapy with an antithrombin inhibitor (hirudin) was also used. Many neutrophils rolled and adhered in postsinusoidal vessels and sequestered in the sinusoids during I/R and local endotoxin superfusion. Although fucoidan blocked rolling in both forms of inflammation, leukocyte recruitment into sinusoids was only blocked in I/R. Adhesion was also inhibited in postischemic sinusoids with a second anti-adhesive agent (hirudin). Because liver I/R inevitably induces ischemia upstream in the intestine, anti-selectin therapy may prevent intestinal injury, which could prevent downstream liver inflammation. To test this hypothesis, we completely removed the intestine and rerouted blood flow from the superior mesenteric artery to the superior mesenteric vein. I/R was induced in the liver microcirculation, and many leukocytes rolled and adhered in postsinusoidal venules and adhered in sinusoids. Although fucoidan significantly reduced the rolling in postsinusoidal vessels, adhesion persisted in the sinusoids. Our data suggest that anti-adhesion therapy is effective in liver I/R in the sinusoids and postsinusoidal venules, perhaps in part due to its beneficial effect on the intestine.

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Soldatova, D. S., A. I. Bezhin, and T. A. Ishunina. "Effectiveness of a combined agent with hemostatic and anti-adhesive activity in liver surgery in an experiment." Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery 25, no. 4 (December 17, 2020): 126–35. http://dx.doi.org/10.16931/1995-5464.20204126-135.

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The aim of this study was to develop a hemostatic agent with anti-adhesive properties and to study its effect on liver morphology, metabolic activity and hepatocyte regeneration in experimental liver injury. Methods. In 60 rats following experimental resection liver injury, the time of bleeding and the volume of blood loss were determined. Histological preparations were used to study the size of hepatocytes and their nuclei, the content of glycogen (PAS-reaction), the number of binucleated hepatocytes and the expression of Ki-67. Results. Compared with the control, an agent based on 6% sodium carboxymethylcellulose gel and 5% aminocaproic acid effectively and reliably reduces the bleeding time by 72% (217.91 s), the volume of blood loss by 74.7% (372.85 mg) (p ≤ 0.01) and the degree of blood filling of the sinusoid liver capillaries. In addition, the use of the novel gel prevents the adhesion formation. It stimulates mitotic activity of hepatocytes, accompanied by an increase in the number of binucleated hepatocytes and Ki-67 expression. By the 14th day, this activity significantly decreases. Hypertrophy of hepatocytes and their nuclei is observed by the 7th and 14th days of the experiment. This indicates both an increase in the metabolic activity of hepatocytes and intracellular regeneration. The use of the hemostatic gel does not alter the glycogen-storing function of hepatocytes, which indicates the lack of pronounced hypoxia due to effective control of bleeding. Conclusion. The local hemostatic gel based on 6% sodium carboxymethylcellulose gel and 5% aminocaproic acid can be recommended for local bleeding control in liver injuries and surgery.

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Ying, Peng Zhan, Hong Fu, Liang Ju Jia, Lei Yu, and Dong Yong Chen. "The Effect of Nanometer Accessory Ingredient on the Function of Water Paint." Advanced Materials Research 92 (January 2010): 277–82. http://dx.doi.org/10.4028/www.scientific.net/amr.92.277.

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The addition of nanometer accessory ingredient in the paint to improve the function of the traditional paint has been the hot topic in the field of anticorrosive paint research. In this paper, three kinds of water nanometer accessory ingredients including anti-abrasive cleaner, hydrophobing agent and anti-aging agent has been added into the paint to combine the nanometer denaturizing paint. The functions of nanometer denaturizing paint such as shellac’s adhesive force, resistance to water, resistance to alkali , and hydrophobic property were measured to evaluate the effect of the accessory ingredint according to the related test standard. It was found that the type and the quantity of nanometer accessory ingredient can effectively modify the function of the water paint. Finally, the optimum parameters were obtained.

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Oh, Chung Hee, Joo Han Oh, Sae Hoon Kim, Jae Hwan Cho, Jong Pil Yoon, and Joon Yub Kim. "Effectiveness of Subacromial Anti-Adhesive Agent Injection after Arthroscopic Rotator Cuff Repair: Prospective Randomized Comparison Study." Clinics in Orthopedic Surgery 3, no. 1 (2011): 55. http://dx.doi.org/10.4055/cios.2011.3.1.55.

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Kim, Hyung-Kyu, Seok Mo Kim, Hojin Chang, Ki-Won Chun, Bup-Woo Kim, Yong Sang Lee, Hang-Seok Chang, and Cheong Soo Park. "Anti-adhesive Agent (Guardix-SG®) Does Not Influence the Drainage Volume after Thyroid Cancer Surgery." Korean Journal of Endocrine Surgery 13, no. 4 (2013): 251. http://dx.doi.org/10.16956/kjes.2013.13.4.251.

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Onat, Bora, Vural Bütün, Sreeparna Banerjee, and Irem Erel-Goktepe. "Bacterial anti-adhesive and pH-induced antibacterial agent releasing ultra-thin films of zwitterionic copolymer micelles." Acta Biomaterialia 40 (August 2016): 293–309. http://dx.doi.org/10.1016/j.actbio.2016.04.033.

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Mitsiades, Constantine S., Cecile Rouleau, Krishna Menon, Beverly Teicher, Massimo Iacobelli, Kenneth C. Anderson, and Paul G. Richardson. "Defibrotide (DF) Targets Tumor-Microenvironmental Interactions and Sensitizes Multiple Myeloma and Solid Tumor Cells to Cytotoxic Chemotherapeutics." Blood 104, no. 11 (November 16, 2004): 286. http://dx.doi.org/10.1182/blood.v104.11.286.286.

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Abstract Introduction: Defibrotide (DF) is a polydisperse oligonucleotide with anti-thrombotic, thrombolytic, anti-ischemic, and anti-adhesive properties, which selectively targets the microvasculature and has minimal hemorrhagic risk. DF is an effective treatment for veno-occlusive disease (VOD), an important regimen-related toxicity in stem cell transplantation characterized by endothelial cell injury. DF also augments stem cell mobilization by modulating adhesion in vivo. Because of its cytoprotective effect on the endothelium, we specifically investigated whether DF protects tumor cells from cytotoxic anti-tumor agents. Further, because of its broad anti-adhesive properties, we evaluated whether DF modulates the interaction of MM cells with bone marrow stromal cells (BMSCs), which confers growth, survival and drug resistance in the BM milieu. Methods: In vitro studies in isogenic dexamethasone (Dex)-sensitive and resistant MM cell lines (MM-1S and MM1R, respectively) showed that DF does not attenuate the sensitivity of MM cells to Dex, the proteasome inhibitor bortezomib (PS-341), melphalan (MEL), vinca alkaloids (vincristine, vinblastine), taxanes (paclitaxel) or platinum (cisplatin), but does decrease their sensitivity to doxorubicin. These selective effects in vitro of DF in protecting tumor cells against doxorubicin and modestly sensitizing MM cells to platinum was also confirmed in solid tumor breast (MCF-7) and colon (HT-29) carcinoma cell lines. Although DF had minimal in vitro inhibitory effect on MM or solid tumor cell growth in vitro, it showed in vivo activity as a single agent and enhanced the responsiveness of MM tumors to cytotoxic chemotherapeutics, such as MEL or cyclophosphamide, in human MM xenografts in SCID/NOD mice. The in vivo single-agent activity and chemosensitizing properties of DF, coupled with its lack of major in vitro activity, suggested that DF may not directly target tumor cells, but rather modulate tumor cell interaction with BMSCs. In an ex vivo model of co-culture of primary MM tumor cells with BMSCs (which protects MM cells against conventional chemotherapy), DF alone had a only modest effect on tumor cell viability, but it significantly enhanced MM cell sensitivity to cytotoxic chemotherapy (e.g. MEL), suggesting that a major component of the biological effects of DF may be attributable not to direct targeting of tumor cells, but to modulation of the interactions that tumor cells develop with the local stromal milieu. Conclusion: Our studies show that DF mediates in vivo anti-MM activity by abrogating interactions of MM cells with their BM milieu, thereby enhancing sensitivity and overcoming resistance to conventional chemotherapy. These data support future clinical trials of DF, in combination with both conventional and novel therapies, to improve patient outcome in MM.

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Kim, Jin Kyong, Cho Rok Lee, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Sung-Rae Cho, Seongmoon Jo, et al. "Efficacy and safety of temperature-sensitive acellular dermal matrix in prevention of postoperative adhesion after thyroidectomy: A randomized, multicenter, double-blind, non-inferiority study." PLOS ONE 17, no. 9 (September 19, 2022): e0273215. http://dx.doi.org/10.1371/journal.pone.0273215.

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Introduction MegaShield® is a newly developed temperature-sensitive anti-adhesive containing micronized acellular dermal matrix. The aim of this study was to investigate the efficacy and safety of MegaShield® compared with Guardix-SG® in the prevention of adhesions in patients undergoing bilateral total thyroidectomy. Method We conducted a multicenter trial between October 2018 and March 2020 in patients undergoing total thyroidectomy. The patients were randomly assigned to either the MegaShield® group or the Guardix-SG® group. The primary outcome was the esophageal movement using marshmallow six weeks after the surgery and the secondary outcome was the assessed adhesion score. The safety assessment was also evaluated. Results The study included 70 patients each in the MegaShield® and control (Guardix-SG®) groups. Baseline clinical characteristics, the mean score of marshmallow esophagography, and the sum of adhesion scores were not statistically different between the two groups. Inferiority test demonstrated that the efficacy of MegaShield® is not inferior to that of Guardix-SG®. There were no device-related complications in both groups. Conclusion The efficacy and safety of MegaShield® were not inferior than those of Guardix-SG®. MegaShield® demonstrated the potential of ADM as a potential future anti-adhesive agent. Trial registration The name of trial registry CRIS (Clinical Research Information Service) https://cris.nih.go.kr/cris/index.jsp. (The full trial protocol can be accessed) Registration number: KCT0003204.

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Li, J., B. Chen, N. Hong, S. Wu, and Y. Li. "Effect of Baicalein on Matrix Metalloproteinases and Durability of Resin-Dentin Bonding." Operative Dentistry 43, no. 4 (July 1, 2018): 426–36. http://dx.doi.org/10.2341/17-097-l.

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SUMMARY Objective: In an attempt to increase resin-dentin bonding quality, this study used baicalein as a preconditioner in an etch-and-rinse adhesive to evaluate its effect on matrix metalloproteinases (MMPs) and adhesive durability. Methods: As a MMP inhibitor and potential collagen cross-linking agent, baicalein was used as a preconditioner in an etch-and-rinse adhesive system. The degree of conversion was evaluated by Fourier-transform infrared spectroscopy. EnzChek gelatinase/collagenase assay kits were then used to detect the MMP inhibitory effect of different concentrations of baicalein (0.1, 0.5, 2.5, and 5.0 μg/mL) on dentin powders. During in vitro bonding procedures, flat dentin surfaces on sound third molars were preconditioned with 2.5 μg/mL baicalein after being acid-etched; this step was followed by continuation of adhesive processes and build-up of resin composite. After resin-dentin stick preparation, bonding strength, failure mode, and interface nanoleakage were respectively evaluated via microtensile testing, stereomicroscopy, and field emission scanning electron microscopy either immediately or after storage in artificial saliva for three or six months. Data were analyzed by two-way analysis of variance and Tukey test (α=0.05). Results: Baicalein at a concentration of 0-5.0 μg/mL did not influence the conversion of adhesives. However, it inhibited the activities of dentin-bond gelatinase and collagenase, especially at a concentration of 2.5 μg/mL, while effectively increasing microtensile bonding strength and decreasing nanoleakage in vitro, both immediately and after aging. Conclusions: Baicalein used as preconditioner in an etch-and-rinse adhesive system has an anti-MMP function and effectively improves resin-dentin bonding durability in vitro, which has potential value in clinical bonding procedures.

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Bang, Seokhwan, Young Hyo Choi, Seung-Ju Lee, and Sung-Hoo Hong. "Collagen Type-I Agent Reduced Postoperative Bowel Adhesions Following Laparoscopic and Robot-Assisted Radical Prostatectomy: A Prospective, Single-Blind Randomized Clinical Trial." Journal of Clinical Medicine 11, no. 17 (August 28, 2022): 5058. http://dx.doi.org/10.3390/jcm11175058.

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This study aimed to compare the anti-adhesive effect of collagen type-I (COL) agent and hyaluronic acid-carboxymethylcellulose (HA/CMC) following laparoscopic and robotic radical prostatectomies. This study was a randomized, controlled, single-blind, multicenter study using COL and HA/CMC in patients who underwent laparoscopic and robotic radical prostatectomies. All patients were randomly assigned to either the COL (n = 66) or HA/CMC (n = 65) group. Viscera slide ultrasound sonography was recorded on the day of surgery (V2) and 12 weeks later (V4). The primary end point was the difference in the excursion distance in the viscera slide ultrasonography between V2 and V4. A total of 131 patients participated in this study. The viscera slide distance in the test and control groups was 1.89 ± 0.49 cm and 1.80 ± 0.45 cm, respectively, at V2 (p = 0.275). The average distance of the viscera slide in the test and control group was 1.59 ± 0.49 cm and 1.64 ± 0.45 cm, respectively at V4 (p = 0.614). None of the patients showed significant adverse effects. This randomized study showed that the efficacy and stability of the gel-type COL anti-adhesion agent are not inferior to those of HA/CMC, of which the properties are established.

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Liu, Jie, Jiawen Sun, Jizhou Duan, Xucheng Dong, Xinping Wang, Chao Liu, and Baorong Hou. "Capsaicin-Modified Fluorosilicone Based Acrylate Coating for Marine Anti-Biofouling." Coatings 12, no. 7 (July 14, 2022): 988. http://dx.doi.org/10.3390/coatings12070988.

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Capsaicin has been extensively studied for its excellent antifouling activity and very low environmental toxicity. However, mixing natural capsaicin with coatings can cause rapid capsaicin leakage, severely shortening its antifouling cycle. In this study, we describe the preparation and performance of a new capsaicin-modified marine antifouling organofluorosilicone, which is based on silicone and fluorine acrylate monomers covalently bound to an organic antimicrobial monomer, HMBA (N-(4-hydroxy-3-methoxybenzyl)-acrylamide) on a polymer network. The chemical grafting of HMBA into the polymer has improved the problem of short antifouling life of the coating due to antifouling agent leakage and the environmental pollution caused by the leakage. The study focused on the synthesis of pristine acrylate monomers with organic bioactive groups prepared from vanillin amine salts and their co-polymerization in the presence of distal acrylate oligomers. The resulting cross-linked films were characterized using infrared spectroscopy, contact angle, and adhesion analyses. The results indicate that the materials had good adhesion, low surface energy, and were resistant to prolonged immersion in water. The polyacrylate coating synthesized from acrylate exhibited antibacterial and anti-algae activity. Biological tests on the marine microorganisms, Pseudomonas species, Shewanella species, and Navicula incerta, revealed a 97%, 98%, and 99% reduction compared to the blank control group, respectively, indicating that the coating has strong anti-adhesive ability. This work is expected to develop a promising material for marine antifouling.

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Nimittrakoolchai, O., and Sitthisuntorn Supothina. "Nanocrystalline TiO₂ Coated-Fabric for UV Shielding and Anti-Bacterial Functions." Materials Science Forum 569 (January 2008): 21–24. http://dx.doi.org/10.4028/www.scientific.net/msf.569.21.

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Due to excellent photocatalytic and optical properties of titanium dioxide (TiO2), it has been applied in several products such as food packaging plastics, materials for vehicles or for buildings and sunscreen-protecting cosmetics. In this present work, the synthesized as well as commercial TiO2 was coated onto a household curtain fabric for anti-microbial and ultraviolet (UV) shielding functions. The coating was performed by inducing the deposition of TiO2 layer from the Ti precursor onto the fabric surface pre-treated with silane adhesive agent so as to improve the adhesion. Ag nanoparticles were also incorporated in some samples to further improve the antibacterial function. Anti-bacterial activities of the coated fabric were evaluated by standard qualitative test (the Kirby-Bauer test (AATCC 147)). Efficiency for UV shielding was evaluated by measuring a UV-Vis reflection of the coated fabrics both before and after subjecting to several washing cycles. The result showed that the TiO2-coated fabrics developed had potential as antibacterial and UV shielding for the curtain industry.

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Daneial, Betty, Jacob Paul Vazhappilly Joseph, and Guruprasad Ramakrishna. "Molecular dynamics simulation analysis of Focal Adhesive Kinase (FAK) docked with solanesol as an anti-cancer agent." Bioinformation 13, no. 09 (September 30, 2017): 274–83. http://dx.doi.org/10.6026/97320630013274.

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Cha, Soo Min, and Hyun Dae Shin. "Effects of a Temperature-sensitive, Anti-adhesive Agent on the Clinical Outcome of Carpal Tunnel Release Surgery." Archives of Hand and Microsurgery 23, no. 2 (2018): 126. http://dx.doi.org/10.12790/ahm.2018.23.2.126.

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Yu, Young-Dong, Dong-Sik Kim, Sung-Won Jung, Jae-Hyun Han, and Sung-Ock Suh. "Influence of anti-adhesive agent on incidence of bile leakage after liver resection: A prospective cohort study." International Journal of Surgery 31 (July 2016): 40–46. http://dx.doi.org/10.1016/j.ijsu.2016.05.062.

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Soldatova, Darya S., Aleksandr I. Begin, and Tatyana A. Ishunina. "Efficacy of the New Hemostatic Composite Based on Sodium Gel Carboxymethylcellulose and Aminocaproic Acid: Experimental Application after Partial Splenectomy in Rats." Journal of Experimental and Clinical Surgery 13, no. 4 (December 13, 2020): 319–25. http://dx.doi.org/10.18499/2070-478x-2020-13-4-319-325.

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Backgraund. Spleen surgery is mainly aimed to achieve effective hemostasis. The increasing popularity of topical hemostatic drugs is limited by their common side effect associated with the development of adhesions.The aim of study was to develop a new hemostatic drug with anti-adhesion activity. To achieve this, the authors have investigated 6% sodium carboxymethylcellulose gel with the addition of 5% aminocaproic acid. Materials and methods. The efficacy of the sample was studied experimentally in laboratory animals (rats, n = 87). The time of bleeding arrest, the amount of blood loss, the severity of the adhesion process, morphological and histological changes in tissues in the area of material implantation were assessed.Results. The study results evidenced that the new hemostatic drug reduced bleeding time by 68% (222.27 sec) and blood loss by 69% (285.6 mg) (p 0.01) after partial splenectomy, and prevented the development of adhesive process compared to the results obtained in the animals of the control group. On the 3rd day of the experiment application of the sample demonstrated that adhesions were completely absent, the coefficient of the severity of the adhesive process was 0 points; on the 7th and 14th days it was minimal - 0.481 and 0.486 points, respectively (p 0.05). A morphological study showed that the use of the new composite reduced the white pulp immunological reactivity associated with postoperative inflammatory processes, which is manifested by smaller lymphoid follicles and lower CD4 + T-lymphocytes expression.Conclusions. Thus, 6% sodium carboxymethylcellulose gel with the addition of 5% aminocaproic acid is an effective combined hemostatic and anti-adhesion agent that can be effectively applied in spleen surgery.

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Kuo, Yu-Ju, Ching-Hu Chung, and Tur-Fu Huang. "From Discovery of Snake Venom Disintegrins to A Safer Therapeutic Antithrombotic Agent." Toxins 11, no. 7 (June 26, 2019): 372. http://dx.doi.org/10.3390/toxins11070372.

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Snake venoms affect blood coagulation and platelet function in diverse ways. Some venom components inhibit platelet function, while other components induce platelet aggregation. Among the platelet aggregation inhibitors, disintegrins have been recognized as unique and potentially valuable tools for examining cell–matrix and cell–cell interactions and for the development of antithrombotic and antiangiogenic agents according to their anti-adhesive and anti-migration effect on tumor cells and antiangiogenesis activities. Disintegrins represent a family of low molecular weight, cysteine-rich, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing polypeptides, which inhibit fibrinogen binding to integrin αIIbβ3 (i.e., platelet glycoprotein IIb/IIIa), as well as ligand binding to integrins αvβ3, and α5β1 expressed on cells (i.e., fibroblasts, tumor cells, and endothelial cells). This review focuses on the current efforts attained from studies using disintegrins as a tool in the field of arterial thrombosis, angiogenesis, inflammation, and tumor metastasis, and briefly describes their potential therapeutic applications and side effects in integrin-related diseases. Additionally, novel R(K)GD-containing disintegrin TMV-7 mutants are being designed as safer antithrombotics without causing thrombocytopenia and bleeding.

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Mugaonkar, Mr Bajirao Anantrao. "Fenugreek Seed." International Journal for Research in Applied Science and Engineering Technology 9, no. 12 (December 31, 2021): 1841–49. http://dx.doi.org/10.22214/ijraset.2021.39611.

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Abstract: Fenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is anannual herb with white flowers and hard, yellowish brown and angular seeds,known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical. Keywords: Chemical composition, Fenugreek gum, Fenugreek, Health benefits

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Park, Cheon-Soo, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, et al. "A comparative study regarding the effect of an intraperitoneal anti-adhesive agent application in left-liver living donors." Korean Journal of Hepato-Biliary-Pancreatic Surgery 18, no. 1 (2014): 26. http://dx.doi.org/10.14701/kjhbps.2014.18.1.26.

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Palla, Viktoria–Varvara, Georgios Karaolanis, Ioannis Katafigiotis, Konstantinos Kontzoglou, and Ioannis Anastasiou. "GnRH Agonists: Are They Ready for Clinical Use as an Anti-adhesive Agent? A Review of the Literature." British Journal of Medicine and Medical Research 5, no. 6 (January 10, 2015): 724–33. http://dx.doi.org/10.9734/bjmmr/2015/13006.

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Gao, Shao Hong, Xian Fu Wei, and Bei Qing Huang. "Effect of Resin on the Property of the Fluorescent Inkjet Ink." Advanced Materials Research 287-290 (July 2011): 49–53. http://dx.doi.org/10.4028/www.scientific.net/amr.287-290.49.

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Digital printing ink imaging is one of main technical fields in digital printing technology development, fluorescence inkjet digital printing is provided with favorable anti-falsification, which is used widely in Securities anti-counterfeiting and labels anti-counterfeiting etc[1]. Printings coated with fluorescence inkjet ink that emits fluorescence under using short-wave ultraviolet light excitation get more favorable anti-falsification. Green fluorescent inkjet ink is composed of phosphor, resin, solvent, assistant agent etc, resin is main one of green fluorescent inkjet ink, which has a significant implication for its property. In order to discuss resins to green fluorescent inkjet ink properties, five samples of fluorescent inkjet ink are prepared, and test various performance parameters of ink samples, such as luminous intensity, surface tension, adhesive force, aridity, and so on. The study result indicated that resins have a great influence on luminous intensity, surface tension, aridity of fluorescence inkjet ink samples, surface tension and viscosity of resins immediately impact surface tension and viscosity of fluorescent inkjet ink.

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Haddaji, Najla, Karima Ncib, Wael Bahia, Mouna Ghorbel, Nadia Leban, Nouha Bouali, Olfa Bechambi, Ridha Mzoughi, and Abdelkarim Mahdhi. "Control of Multidrug-Resistant Pathogenic Staphylococci Associated with Vaginal Infection Using Biosurfactants Derived from Potential Probiotic Bacillus Strain." Fermentation 8, no. 1 (January 1, 2022): 19. http://dx.doi.org/10.3390/fermentation8010019.

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Biosurfactants exhibit antioxidant, antibacterial, antifungal, and antiviral activities. They can be used as therapeutic agents and in the fight against infectious diseases. Moreover, the anti-adhesive properties against several pathogens point to the possibility that they might serve as an anti-adhesive coating agent for medical inserts and prevent nosocomial infections, without using synthetic substances. In this study, the antimicrobial, antibiofilm, cell surface hydrophobicity, and antioxidative activities of biosurfactant extracted from Bacillus sp., against four pathogenic strains of Staphylococcus spp. associated with vaginal infection, were studied. Our results have shown that the tested biosurfactant possesses a promising antioxidant potential, and an antibacterial potency against multidrug clinical isolates of Staphylococcus, with an inhibitory diameter ranging between 27 and 37 mm, and a bacterial growth inhibition at an MIC of 1 mg/ mL, obtained. The BioSa3 was highly effective on the biofilm formation of different tested pathogenic strains. Following their treatment by BioSa3, a significant decrease in bacterial attachment (p < 0.05) was justified by the reduction in the optical (from 0.709 to 0.111) following their treatment by BioSa3. The antibiofilm effect can be attributed to its ability to alter the membrane physiology of the tested pathogens to cause a significant decrease (p < 0.05) of over 50% of the surface hydrophobicity. Based on the obtained result of the bioactivities in the current study, BioSa3 is a good candidate in new therapeutics to better control multidrug-resistant bacteria and overcome bacterial biofilm-associated infections by protecting surfaces from microbial contamination.

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Chałada, Ł., M. Adamiak, and A. Woźniak. "Evaluation of properties of anti-adhesive coatings on the surface of injection moulds made of Al alloys." Archives of Materials Science and Engineering 1-2, no. 97 (May 1, 2019): 5–11. http://dx.doi.org/10.5604/01.3001.0013.2865.

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Purpose: The aim of the research was to determine the most favourable fluoropolymer coatings, deposited on the surface of aluminium moulds, which will be used to share improvements in automotive sectors. Design/methodology/approach: The paper presents the results of the coatings thickness and surface roughness measurements, AFM analysis, contact angle measurements and surface free energy calculation, wear test and adhesion force measurement of three fluoropolymer coatings. Findings: On the basis of the investigation, it can be stated that the properties of the tested coating and their adhesion to the aluminium substrate are different. Based on the obtained results it can be concluded that the coating named Coat_134 was characterized by the optimum properties - well anti-adhesion properties and good mechanical properties. Research limitations/implications: Coating must be applied on the surface of injection tools, with complex shape and wide range of dimensions. Practical implications: Injection moulds for polyurethane foam, reduction of release agent consumption. Originality/value: The paper presents comparative research of fluoropolymer coatings in order to determinate adhesion to polyurethane foam with low density.

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Costa, Laís Maciel, Ariela Vilela Rizuto, Luciana Sarmento de Mendonça, Marianne de Vasconcelos Carvalho, Márcia Maria Fonseca da Silveira, and Ana Paula Veras Sobral. "Immunoxpression of MMPs -9, -13 and TIMP-3 after Using Etch-and-rinse Adhesive." Research, Society and Development 10, no. 9 (July 19, 2021): e14010917315. http://dx.doi.org/10.33448/rsd-v10i9.17315.

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The aim of the present study was to determine the expression of MMP-9, MMP-13 and TIMP-3 after using the XP Bond ™ (Dentsply) dentin-bonding agent on 21 human teeth. Class I deep cavities were prepared and restored. After 01, 07, 14, 21, 30, 90 and 120 days, the teeth were extracted and processed for an immunohistochemical assessment (n=3). Immunohistochemical staining was performed using the monoclonal antibody anti-MMP-9, and polyclonal antibodies anti-MMP-13 and anti-TIMP-3. The immunoreactivity of metalloproteinases 9 and 13 was considered intense and moderate in the first storage intervals, before decreasing over time. In contrast, the immunoreactivity of TIMP-3 was considered absent in dentin and weak in pulp in the first time intervals, and completely absent in the subsequent intervals. MMP-9 expression in dentin and in pulp was prevalent in the dentinal tubules and odontoblastic layer, respectively. MMP-13 expression in dentin and in pulp was predominant in the pre-dentine region and odontoblastic layer, respectively. TIMP-3 expression was absent in dentin and predominantly located in the odontoblastic layer for pulp. In conclusion, the expression patterns of MMP-9, MMP-13 and TIMP-3 altered in the different time intervals studied. The increased expression of TIMP-3 in the first time intervals could suggest a synchronous response to the increased expression of MMPs in the same periods. The results confirmed the low performance of TIMP-3 in the physiological processes of the pulp-dentin complex for the conditions and materials tested herein.

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Huang, Beili, Shanshan Jiang, Yunhe Diao, Xuying Liu, Wentao Liu, Jinzhou Chen, and Huige Yang. "Hydrogels as Durable Anti-Icing Coatings Inhibit and Delay Ice Nucleation." Molecules 25, no. 15 (July 25, 2020): 3378. http://dx.doi.org/10.3390/molecules25153378.

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The accumulation of ice on surfaces brings dangerous and costly problems to our daily life. Thus, it would be desirable to design anti-icing coatings for various surfaces. We report a durable anti-icing coating based on mussel-inspired chemistry, which is enabled via fabricating a liquid water layer, achieved by modifying solid substrates with the highly water absorbing property of sodium alginate. Dopamine, the main component of the mussel adhesive protein, is introduced to anchor the sodium alginate in order to render the coating applicable to all types of solid surfaces. Simultaneously, it serves as the cross-linking agent for sodium alginate; thus, the cross-linking degree of the coatings could be easily varied. The non-freezable and freezable water in the coatings with different cross-link degrees all remain liquid-like at subzero conditions and synergistically fulfill the aim of decreasing the temperature of ice nucleation. These anti-icing coatings display excellent stability even under harsh conditions. Furthermore, these coatings can be applied to almost all types of solid surfaces and have great promise in practical applications.

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Chauhan, Anil K., David G. Motto, Colin B. Lamb, Michael Dockal, Friedrich Scheiflinger, David Ginsburg, and Denisa D. Wagner. "The Metalloprotease ADAMTS13 Is a Natural Anti-Thrombotic." Blood 106, no. 11 (November 16, 2005): 409. http://dx.doi.org/10.1182/blood.v106.11.409.409.

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Abstract The metalloprotease ADAMTS13 cleaves highly adhesive ultra large von Willebrand factor (UL-VWF) multimers after their release from the endothelium. UL-VWF is stored in Weibel-Palade bodies of endothelial cells. ADAMTS13 deficiency is linked to a life threatening disorder, thrombotic thrombocytopenic purpura (TTP), which is characterized by VWF and platelet-rich thrombi in the microvasculature, and may lead to organ ischemia, neurological dysfunction and ultimately death. We previously confirmed in vivo that in Adamts13−/− mice and not in wild-type mice “strings of platelets” formed after endothelial activation. The VWF strings remain attached at one end to the endothelium and “waved” the other end in the blood stream. In addition, we showed prolonged adhesion of platelets to secreted VWF on endothelium of Adamts13−/− mice. The possible role of ADAMTS13 in platelet plug formation has not been addressed previously. We investigated thrombosis in venules and arterioles of Adamts13−/− mice by intravital microscopy. Mesenteric microvenules were stimulated with calcium ionophore A23187, a secretagouge of Weibel-Palade bodies. In the Adamts13−/− mice we observed spontaneous thrombus formation in the activated microvenules. Inhibitory antibody to plasma ADAMTS13 induced thrombi formation in the activated microvenules and prolonged adhesion of platelets to secreted VWF on endothelium of wild-type mice. In the ferric chloride arterial injury model we found that the number of fluorescent platelets deposited within 2–3 min on the sub-endothelium after injury was unexpectedly higher in Adamts13−/− mice as compared to Adamts13+/+ mice (P<0.05). In the Adamts13−/− mice, platelet plug grew faster as thrombi >30 um were seen at 6.6±0.9 min compared to 10.8±0.8 min in the Adamts13+/+ mice (P<0.005). The platelet plug reached occlusive size in 10.6±0.7 min in Adamts13−/− mice, whereas in the Adamts13+/+ mice all the vessels were still open at this time. In the Adamts13+/+, the mean vessel occlusion time was 16.7±1.2 min after injury (P<0.0005). Thus ADAMTS13, by cleaving VWF multimers, down regulates both platelet adhesion to exposed subendothelium and thrombus growth. Furthermore, we observed that recombinant human ADAMTS13 inhibited formation of VWF platelet strings in histamine-activated venules and promoted thrombi dissolution in the Adamts13−/− mice. Our findings reveal that ADAMTS13 has natural anti-thrombotic activity and recombinant ADAMTS13 could be used as an anti-thrombotic agent.

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Ren, Jingwen, Yan Qin, Zhengwei Peng, and Zhuangzhuang Li. "Influence of composite structure design on the ablation performance of ethylene propylene diene monomer composites." e-Polymers 21, no. 1 (January 1, 2021): 151–59. http://dx.doi.org/10.1515/epoly-2021-0015.

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Abstract By introducing functional fillers into the ethylene propylene diene monomer matrix, the anti-ablation, thermal insulation, and adhesive layer were prepared, respectively. We have studied the mechanical properties, ablation properties, thermal insulation properties, and bonding properties of different composite structures after design and analyzed the ceramic mechanism. The results showed that the content of ceramic fillers improved the thermal stability and ablation properties of anti-ablation layer composites. The formation of liquid structure can fill the hole defects and ablation pit. The foaming agent improved thermal insulation properties of the thermal insulation layer, and the strength of the bonding layer has been greatly improved. The design of the composite structure can not only reduce the density but also have an excellent thermal insulation effect. And as the thickness of the heat insulation layer increases, the heat blocking effect becomes more excellent.

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Akpinar, Edip. "Peer review report 1 on “Influence of anti-adhesive agent on incidence of bile leakage after liver resection - Cohort study”." International Journal of Surgery 25 (January 2016): 282. http://dx.doi.org/10.1016/j.ijsu.2016.07.047.

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Nagahara, Naoki, Yohko Akiyama, Masafumi Nakao, Mayumi Tada, Megumi Kitano, and Yasuyuki Ogawa. "Mucoadhesive Microspheres Containing Amoxicillin for Clearance of Helicobacter pylori." Antimicrobial Agents and Chemotherapy 42, no. 10 (October 1, 1998): 2492–94. http://dx.doi.org/10.1128/aac.42.10.2492.

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ABSTRACT In an effort to augment the anti-Helicobacter pylorieffect of amoxicillin, mucoadhesive microspheres, which have the ability to reside in the gastrointestinal tract for an extended period, were prepared. The microspheres contained the antimicrobial agent and an adhesive polymer (carboxyvinyl polymer) powder dispersed in waxy hydrogenated castor oil. The percentage of amoxicillin remaining in the stomach both 2 and 4 h after oral administration of the mucoadhesive microspheres to Mongolian gerbils under fed conditions was about three times higher than that after administration in the form of a 0.5% methylcellulose suspension. The in vivo clearance ofH. pylori following oral administration of the mucoadhesive microspheres and the 0.5% methylcellulose suspension to infected Mongolian gerbils was examined under fed conditions. The mucoadhesive microspheres and the 0.5% methylcellulose suspension both showed anti-H. pylori effects in this experimental model of infection, but the required dose of amoxicillin was effectively reduced by a factor of 10 when the mucoadhesive microspheres were used. In conclusion, the mucoadhesive microspheres more effectively cleared H. pylori from the gastrointestinal tract than the 0.5% methylcellulose suspension due to the prolonged gastrointestinal residence time resulting from mucoadhesion. A dosage form consisting of mucoadhesive microspheres containing an appropriate antimicrobial agent should be useful for the eradication of H. pylori.

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Hao, Long, Ye Ming Zhang, Chao Yang, Hua Zhu, Xu Hui Mao, An Lin, and Fu Xing Gan. "Study on Electroless Ni-P Deposit on W-Cu Alloy and its Anti-Corrosion Mechanism." Key Engineering Materials 373-374 (March 2008): 240–43. http://dx.doi.org/10.4028/www.scientific.net/kem.373-374.240.

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With suitable pretreatment, a compact and even nickel-phosphorus alloy coating was obtained on W-Cu alloy by electroless deposition from solutions containing nickel sulphate as a source of nickel and sodium hypophosphite as the reducing agent and a source of phosphorus. The Ni-P coating was normally prepared from acidic baths at high temperature of the order of 90oC with the pH of 4.8 and it was smooth and uniform and exhibited high crystal refinement and high microhardness and superior corrosion resistance. The microhardness, adhesion and corrosion resistance mechanism of Ni-P deposit were studied. The microhardness of the Ni-P alloy deposit increases greatly by tempering at various temperatures. The Ni-P deposit has a strong adhesive force with W-Cu alloy substrate checked by thermal shock test and scribe test. The anti-corrosion ability of Ni-P coating and its anti-corrosion mechanism were measured using immersion experiment and potentiodynamic polarization techniques. The results showed that the corrosion resistance of Ni-P coating was higher than that of W-Cu alloy substrate in the 10vol.% sulfuric acid, monitoring sweat solution and 3.5wt.% sodium chloride solution. The anti-corrosion mechanism of electroless Ni-P coating immersed in 3.5wt.% sodium chloride solution was studied using potentiodynamic polarization techniques. The surface micromorphological morphology and structure of the Ni-P coating were investigated using Scanning Electronic Microscope (SEM) and X-ray Diffraction (XRD). The results indicated that the Ni-P alloy coating consisted of microcrystals and it was amorphous in structure, and the electrochemical measurement showed passive film formed on Ni-P coating during immersion test in the 3.5wt.% sodium chloride solution.

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Kvashnina, A. A., M. G. Melnychenko, and V. F. Rybalchenko. "Clinical effectiveness of sodium hyaluronate gel usage for prevention of postoperative adhesion in children." Modern pediatrics. Ukraine, no. 2(122) (March 30, 2022): 21–26. http://dx.doi.org/10.15574/sp.2022.122.21.

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It was considered expedient to study the effectiveness of intraoperative prevention of adhesion formation in children based on the results of our own experimental and clinical studies on the effectiveness of using an anti-adhesive gel based on cross-linked sodium hyaluronate. Purpose - to evaluate clinical efficacy and safety of cross-linked sodium hyaluronate gel (SHG) usage as a barrier agent for primary prevention of postoperative peritoneal adhesions formation in children. Materials and methods. This is a prospective, randomized, controlled, patient blinded observational study, which includes 62 children. All patients underwent laparotomy for appendicular peritonitis and were randomly divided into two equal groups. Patients from group A (n=31) received conventional surgical treatment, SHG was additionally applied in group B (n=31) before abdominal closure. Immediate and long-term effects of SHG usage were investigated to evaluate the influence on adhesions reformation. The average period of postoperative observation was 14.0±2.4 months. Results. SHG application was associated with no increase in complications rate: duration of postoperative ileus, need in nasogastric decompression, intensive care unit state, hospital state, the incidence of surgical site infection, and need for relaparotomy did not differ significantly between compared groups. The prevalence of peritoneal adhesions at the end of in-hospital treatment differs significantly between groups according to the ultrasound data (χ2=10.930; p=0.005). The incidence of small bowel obstruction (SBO) developed during the follow-up period in group A (16.1%) was significantly higher than in group B (3.23%) where the anti-adhesive gel was applied (χ2=4.026; p=0.045). Conclusions. Intraoperative use of SHG based on sodium hyaluronate allows reduction of postoperative adhesions formation in children without worsening the postoperative course. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: sodium hyaluronate, adhesions, small bowel obstruction.

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McDonald, Glenn A., Pradip Sarkar, Helmut Rennke, Elaine Unemori, Raghu Kalluri, and Vikas P. Sukhatme. "Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo." American Journal of Physiology-Renal Physiology 285, no. 1 (July 2003): F59—F67. http://dx.doi.org/10.1152/ajprenal.00157.2002.

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Fibronectin, a large adhesive glycoprotein, is a prominent constituent of the extracellular matrix. Abnormalities in fibronectin homeostasis occur in numerous disease states, ranging from primary fibrosing conditions to neoplastic transformation. We demonstrate that fibronectin is a target protein substrate for ubiquitin-dependent degradation. Coimmunoprecipitation experiments and confocal microscopy demonstrated ubiquitin-fibronectin interaction. In an in vitro model of renal fibrosis, relaxin, an insulin-like growth factor, increased ubiquitin-dependent fibronectin degradation. Relaxin also was evaluated in an anti-glomerular basement membrane model of renal fibrosis. Animals treated with relaxin experienced renoprotection, manifested by decreased serum creatinine and proteinuria. Histological evaluation of kidney sections from animals treated with relaxin showed decreased glomerulosclerosis and interstitial fibrosis. We conclude that relaxin might be developed as a useful agent for the treatment of renal fibrosis.

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Tsai, Cheng-Chih, Kuan-Jung Huang, and Pei-Pei Lin. "Lactobacillus spp. inhibits the growth of HCT-116 and reduces IL-8 secretion by Salmonella typhimurium-infected HCT-116 colorectal carcinoma cells." International Journal of Food Studies, no. 2 (October 18, 2022): 307–19. http://dx.doi.org/10.7455/ijfs/11.2.2022.a5.

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Salmonella typhimurium causes symptoms resembling typhoid fever and gastroenteritis in humans. Its toxicity is due to an outer membrane consisting largely of lipopolysaccharides (LPS) which is responsible for the host immune response. The aim of this study is to evaluate the antimicrobial, anti-apoptotic ability of Lactobacillus plantarum and reduce Salmonella-induced pro-inflammatory cytokine IL-8 secretion. Adhesive tests were performed using lactobacilli co-cultured with the colon cancer cell line HCT-116 for 2 hours. The strains displaying the highest adhesion were selected for downstream 3- (4, 5- Dimethylthiazol -2-yl) -2, 5- diphenyltetrazolium bromide (MTT) tests to assess cytotoxicity. The supernatants of Lactobacillus cultured with HCT-116 cells for 24 and 48 h to evaluate the inhibitory effect. To determine Interleukin 8 (IL-8) secretion in colon cancer induced by S. typhimurium, we stimulated HCT-116 cells with S. typhimurium and co-cultured with lactobacilli for 24 h. Lactobacilli had the most significant inhibitory effects on cell growth, and their inhibitory effects were time-dependent. Strain No. 03-03-026 caused cancer cell deoxyribonucleic acid (DNA) fragmentation, and the anti-apoptosis protein (B-cell lymphoma 2) was reduced in the HCT-116 cells as determined. IL-8 production in colon cancer cells was significantly reduced by these lactobacilli. Our results suggested that lactobacilli maybe effectively reduce the numbers of S. typhimurium, IL-8 levels and the anti-apoptotic phosphorylated-p38 mitogen-activated protein kinase and B-cell lymphoma 2 proteins. Lactobacillus can be added to the diet as a food additive to prevent colorectal cancer and used to be the prophylactic agent against S. typhimurium.

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Journal articles on the topic 'Anti adhesive agent'

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