Relevant bibliographies by topics / Anti adhesive agent

Academic literature on the topic 'Anti adhesive agent'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Anti adhesive agent"

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TAKEUCHI, Toshiya. "History and Future of Anti-Adhesive Agent." NIPPON GOMU KYOKAISHI 93, no. 6 (2020): 190–94. http://dx.doi.org/10.2324/gomu.93.190.

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Emanuele, R. Martin. "FLOCOR™: a new anti-adhesive, rheologic agent." Expert Opinion on Investigational Drugs 7, no. 7 (July 1998): 1193–200. http://dx.doi.org/10.1517/13543784.7.7.1193.

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Hassan, Nisreen, Mushir Ali, and Javed Ali. "Novel buccal adhesive system for anti-hypertensive agent Nimodipine." Pharmaceutical Development and Technology 15, no. 2 (November 13, 2009): 124–30. http://dx.doi.org/10.3109/10837450903055494.

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Gutsaeva, Diana R., James B. Parkerson, Shobha D. Yerigenahally, Jeffrey C. Kurz, Robert G. Schaub, Tohru Ikuta, and C. Alvin Head. "Inhibition of cell adhesion by anti–P-selectin aptamer: a new potential therapeutic agent for sickle cell disease." Blood 117, no. 2 (January 13, 2011): 727–35. http://dx.doi.org/10.1182/blood-2010-05-285718.

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Abstract Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti–P-selectin aptamer and examined its effects on cell adhesion using knockout-transgenic SCD model mice. Aptamers, single-stranded oligonucleotides that bind molecular targets with high affinity and specificity, are emerging as new therapeutics for cardiovascular and hematologic disorders. In vitro studies found that the anti–P-selectin aptamer exhibits high specificity to mouse P-selectin but not other selectins. SCD mice were injected with the anti–P-selectin aptamer, and cell adhesion was observed under hypoxia. The anti–P-selectin aptamer inhibited the adhesion of sickle RBCs and leukocytes to endothelial cells by 90% and 80%, respectively. The anti–P-selectin aptamer also increased microvascular flow velocities and reduced the leukocyte rolling flux. SCD mice treated with the anti–P-selectin aptamer demonstrated a reduced mortality rate associated with the experimental procedures compared with control mice. These results demonstrate that anti–P-selectin aptamer efficiently inhibits the adhesion of both sickle RBCs and leukocytes to endothelial cells in SCD model mice, suggesting a critical role for P-selectin in cell adhesion. Anti–P-selectin aptamer may be useful as a novel therapeutic agent for SCD.
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Zhong, Jian Hua, Zhi Hong Li, and Ling Yu Ouyang. "Study on the Anti-Oxidant Property of Copper Powder Coated Silane Coupling Agent in Isotropically Conductive Adhesives." Advanced Materials Research 139-141 (October 2010): 117–20. http://dx.doi.org/10.4028/www.scientific.net/amr.139-141.117.

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In this experiment, the micro copper powders with high temperature of oxidation resistance were prepared by coating with 2 wt.% of silane coupling agent(KH560) solution in order to protect them from oxidation in isotropically conductive adhesives, and X-ray diffraction analysis(XRD), thermo gravimetric analysis(TGA) and accelerated aging test were applied to analyze the anti-oxidant property of the samples before and after they were treated. Experimental results showed that the polymer of silane coupling agent on the surfaces of copper powders had high thermal stability exposed under high temperature and was very effective in preventing the copper powders from oxidation in isotropically conductive adhesives. Besides, the epoxy conductive adhesive sample with plated copper as electrically conductive fillers still had good conductive property even exposed at 160 degrees with its bulk resistivity was 8.75×10-3Ω•cm.
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KAWAHARA, Kazuki, Hiroya OKI, and Shota NAKAMURA. "Structural Study of Bacterial Pili for Development of the Anti-Adhesive Agent." Nihon Kessho Gakkaishi 62, no. 3 (August 31, 2020): 139–40. http://dx.doi.org/10.5940/jcrsj.62.139.

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Allegrone, Gianna, Chiara Ceresa, Maurizio Rinaldi, and Letizia Fracchia. "Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm." Pharmaceutics 13, no. 8 (July 29, 2021): 1172. http://dx.doi.org/10.3390/pharmaceutics13081172.

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A major challenge in the biomedical field is the creation of materials and coating strategies that effectively limit the onset of biofilm-associated infections on medical devices. Biosurfactants are well known and appreciated for their antimicrobial/anti-adhesive/anti-biofilm properties, low toxicity, and biocompatibility. In this study, the rhamnolipid produced by Pseudomonas aeruginosa 89 (R89BS) was characterized by HPLC-MS/MS and its ability to modify cell surface hydrophobicity and membrane permeability as well as its antimicrobial, anti-adhesive, and anti-biofilm activity against Staphylococcus aureus were compared to two commonly used surfactants of synthetic origin: Tween® 80 and TritonTM X-100. The R89BS crude extract showed a grade of purity of 91.4% and was composed by 70.6% of mono-rhamnolipids and 20.8% of di-rhamnolipids. The biological activities of R89BS towards S. aureus were higher than those of the two synthetic surfactants. In particular, the anti-adhesive and anti-biofilm properties of R89BS and of its purified mono- and di-congeners were similar. R89BS inhibition of S. aureus adhesion and biofilm formation was ~97% and 85%, respectively, and resulted in an increased inhibition of about 33% after 6 h and of about 39% after 72 h when compared to their chemical counterparts. These results suggest a possible applicability of R89BS as a protective coating agent to limit implant colonization.
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Kharouf, Naji, Ammar Eid, Louis Hardan, Rim Bourgi, Youri Arntz, Hamdi Jmal, Federico Foschi, et al. "Antibacterial and Bonding Properties of Universal Adhesive Dental Polymers Doped with Pyrogallol." Polymers 13, no. 10 (May 11, 2021): 1538. http://dx.doi.org/10.3390/polym13101538.

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This study investigated the antibacterial activity, bond strength to dentin (SBS), and ultra-morphology of the polymer–dentin interface of experimental adhesive systems doped with pyrogallol (PY), which is a ubiquitous phenolic moiety that is present in flavonoids and polyphenols. A universal adhesive containing 4-META and 10-MDP was used in this study. PY behaves as an antioxidant and anti-cancerogenic agent and it was incorporated into the adhesive at different concentrations (0.5 and 1 wt.%). The antibacterial activity and SBS were analyzed and the results were statistically analyzed. The ultra-morphology of the polymer–dentin interface was assessed using scanning electron microscopy (SEM). At 24 h, a lower antibacterial activity was observed for the control adhesive compared to those with 0.5% and 1% PY. No difference was seen in SBS between the three groups at 24 h. After 6 months, the SBS of the 0.5% PY adhesive was significantly lower than the other tested adhesives. The specimens created with 1% PY adhesive presented a higher bond strength at six months compared with that found at 24 h. No morphological differences were found at the polymer–dentin interfaces of the tested adhesives. Pyrogallol may be incorporated into modern universal adhesive systems to preserve the polymer–dentin bonding interface and confer a certain degree of antibacterial activity.
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Kim, Kwang-Il, Ha-Na Na, Yoshihiro Ito, and Tae-Il Son. "Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent." Macromolecular Research 19, no. 3 (March 2011): 216–20. http://dx.doi.org/10.1007/s13233-011-0303-4.

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Zhang, De Cheng, Dong Yu Xu, and Xin Cheng. "Research on High Performance Sulfoaluminate Cement Underwater Non-Dispersed Concrete." Advanced Materials Research 306-307 (August 2011): 956–60. http://dx.doi.org/10.4028/www.scientific.net/amr.306-307.956.

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Sulfoaluminate cement, non-ionic polyacrylamide and sulfamate high-effective water reducing agent were used as main raw materials to fabricate concrete. The adhesive performance of high performance sulfoaluminate cement underwater non-dispersed concrete and its influence on water quality in surrounding water areas were studied. The compressive strength ratio of concrete cast in water and in air was also determined. The results show that mortar and concrete using non-ionic polyacrylamide as adhesion agent has many advantages such as superior underwater anti-washout properties, little pollution to water quality in the surrounding water areas and obvious early strength. Furthermore, the compressive strength ratio of concrete cast in water and in air is also up to the required standard.
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Dissertations / Theses on the topic "Anti adhesive agent"

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Rodrigues, Roberta Bento. "Avaliação in vitro da ação anti-bacteriana de um adesivo auto-condicionante acrescido de clorexidina." Universidade Estadual do Oeste do Paraná, 2016. http://tede.unioeste.br/handle/tede/3830.

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Adhesive technology has been developed quickly since its introduction about fifty years ago. Its goal is to produce a close contact within enamel and dentin. Failures in this process could result in microleakage, and allow the infiltration of bacteria, fluids and ions. Recent studies have been shown the use of chlorhexidine associated with adhesive systems can be able to inhibit the bacteria action. The aim of this study was to evaluate the addiction of different percentages of chlorhexidine to a self-etch adhesive. The solution of digluconate chlorhexidine was increased to the primer of the two pass self-etch adhesive to create a 0,5%, 1,0% and 2,0% chlorhexidine primer solution and after they were distributed in four groups (G1, G2, G3 and G4). Saliva samples (N=10) were used to test bacteria activity. They were spread in a blood medium with filter paper disks containing the different treatments. After the incubation, the inhibitions halos formation were evaluated. This study demonstrated that, in vitro, the addition of different percentages of chlorhexidine digluconate to the self-etch adhesive induced inhibited halos at bacteria of saliva samples, independent from their concentration.
A tecnologia adesiva vem se desenvolvendo rapidamente desde que foi introduzida há mais de 50 anos. Seu principal objetivo é alcançar um íntimo contato entre a estrutura dental e o material restaurador e fornecer adequada adesão entre o esmalte e a dentina. Falhas nesse processo adesivo podem resultar em microinfiltração marginal com passagem de bactérias, fluidos ou íons entre a parede cavitária e o material restaurador. Recentes estudos têm demonstrado que a utilização da clorexidina associada ao sistema adesivo pode ser capaz de inibir a ação das bactérias. O objetivo do presente estudo foi avaliar o efeito antibacteriano de um sistema adesivo auto-condicionante de dois passos associado a diferentes concentrações de solução de digluconato de clorexidina. A solução de digluconato de clorexidina a 20% foi adicionada ao primer do sistema adesivo nas concentrações de 0,5, 1,0 e 2,0% e distribuídas em quatro grupos (G1, G2, G3 e G4). Para o teste de atividade antibacteriana foram utilizadas amostras de saliva (N=10) semeadas em meio de ágar sangue e discos de papel filtro contendo os diferentes grupos. Após incubação, as amostras foram inspecionadas quanto à formação de halo de inibição dos microrganismos através da utilização do paquímetro digital de precisão(0,0001mm) (Mitutoyou Sul Americana Ltda/ Starret Tools®). Este trabalho demonstrou que, in vitro, a adição de diferentes concentrações de digluconato de clorexidina ao sistema adesivo produziu halo de inibição dos microrganismos presentes nas amostras de saliva, independente da concentração utilizada.
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Dagia, Nilesh M. "Transcription Inhibitors as Anti-Adhesion Agents." Ohio University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1089820343.

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Vrlinič, Tjaša. "Development of new anti-bioadhesive surfaces for specific neurodegenerative agents." Phd thesis, Université du Maine, 2011. http://tel.archives-ouvertes.fr/tel-00603911.

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Ces travaux de recherche s'inscrivent dans le cadre du développement de nouvelles surfaces biocompatibles capables de contrôler l'adhésion d'agents pathogènes responsables de maladies neurodégénératives telles que les maladies de Creutzfeld Jacob, Alzheimer, Parkinson et Lewis. Deux axes de recherche ont été privilégiés. Notre approche se focalise en amont des dosages sur l'amélioration des procédures de stockage des prélèvements biologiques réalisés dans des tubes de type Eppendorf. Ces tubes en polypropylène induisent une perte du matériel génétique de plus de 70% accentuant la faible concentration en agent pathogène pour la détection immunoenzymatique. Dans le but de réduire les phénomènes indésirables d'adhésion des agents pathogènes à la surface des supports de stockage, deux voies de traitement ont été envisagées dans ce travail de thèse. La première consiste à modifier la surface du tube Eppendorf en une étape par décharge plasma fluoré, la seconde à créer de nouvelles surfaces hydrophiles en deux étapes couplant la technique des plasmas froids au greffage de polymères, les agents pathogènes pouvant être hydrophiles ou hydrophobes. Avec cette dernière technique, une voie originale a été abordée de part l'utilisation de solutions de greffage complexes composées à la fois de polymères et de molécules tensioactives. Les surfaces ainsi obtenues présentent une nano-structuration. Toutes les étapes de modification de la surface interne des tubes de stockage ont été caractérisées. Ces surfaces sont alors décrites selon leur caractère hydrophile ou hydrophobe grâce à la détermination des énergies de surface polaire et apolaire, selon leur charge de surface obtenue par mesure du potentiel d'écoulement, selon leur composition chimique déterminée par spectroscopie à photoélectrons X (XPS) et enfin selon leur topographie et leur rugosité relevées par microscopie à force atomique (AFM). Les interactions entre les groupements fonctionnels ainsi obtenus à la surface des tubes de stockage après les divers traitements et les protéines antigéniques considérées ont été interprétées en se référant aux différents modèles de l'adhésion pour des gammes de pH proches des protocoles biologiques usuels. Afin de s'assurer que ces nouvelles surfaces permettent bien une diminution de l'adhésion des agents infectieux sur la paroi interne des tubes de polypropylène, des analyses immunoenzymatiques ont été réalisées au sein des centres hospitaliers participant au projet STREP NEUROSCREEN n° LSHB-CT 2006-03 7719 (CRPP de Liège et CHU de Lyon). Ces analyses ont permis de montrer que la modification des surfaces entraîne une diminution de l'absorption des agents pathogènes jusqu'à 100% permettant ainsi une meilleure détection.
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Grimes, Kimberly D. "Design, synthesis, and evaluation of small molecules in the discovery of novel antimicrobial agents." View the abstract Download the full-text PDF version (on campus access only), 2008. http://etd.utmem.edu/ABSTRACTS/2008-021-GrimesK-index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2008.
Title from title page screen (viewed on September 4, 2008). Research advisor: Richard E. Lee, Ph.D. Document formatted into pages (xiii, 124 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 109-124).
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Jensen, Heidi Dorte. "Cranberry juice and urinary tract infections /." Copenhagen : Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut : Department of Medicinal Chemistry, The Danish University of Pharmaceutical Science, 2004. http://www.dfh.dk/phd/defences/HeidiDorteJensen.htm.

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PERALTA, Sonia Luque. "Incorporação do óleo essencial de Butia capitata como antibacteriano em um adesivo experimental." Universidade Federal de Pelotas, 2011. http://repositorio.ufpel.edu.br/handle/ri/2230.

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The aim of this study was to evaluate the antimicrobial effect and physical mechanical properties of a self-etching experimental adhesive after the incorporation of an essential oil obtained from Butiá´s seeds (Butia capitata). It was formulated a two-step self-etching adhesive system composed of dentin primer and bond (cover resin). The primer was prepared with fixed amounts of 2-Hidroxiethyl methacrylate (HEMA), phosphoric acid ester monomer and solvent. The cover resin (bond) was prepared with a homogeneous mixture of Biphenyl-A glicidil dimethacrylate (Bis-GMA), Triethyleneglycol dimethacrylate (TEGDMA), HEMA, photoinitiators as camphoroquinone (CQ) and Ethyl 4-dimethyl amine benzoate (EDMAB); and 1% Butia Capitata‟ seeds oil (butiá). Three adhesives have been tested as commercial references: Clearfil Protect Bond (CPB), Clearfil SE Bond (CSEB) and Adper SE Plus (AP), and two experimental adhesives: Control adhesive without oil (CA), and experimental adhesive containing butiá´s oil (EA). The antimicrobial effect of adhesives was evaluated by the methods of biofilm growth inhibition in a Streptococcus mutans monoculture assay and by the microcosm technique. The physical mechanical performance of these adhesives was evaluated by micro tensile bond strength (μTBS), degree of conversion (DC), and water sorption (WS) and solubility (SL). It also was evaluated the biocompatibility by the genotoxicity and cytotoxicity assays. The data were statistically analyzed by analysis of variance and complementary tests. In the assay of anti-S. mutans biofilm , AP showed the highest effect, followed by EA and CPB. In the microcosm assay, high viability was found in AC for total microorganisms, and minor viability was found in C, EA and CPB for total aciduric. While for total Lactobacillus most viability was found in C and AC, and for S. mutans , all groups had similar values. For the GC, WA, SL e μTBS tests EA was similar to CA, but after six months of aging the μTBS values were reduced for EA. Regarding the cytotoxicity the CPB primer and the AP bond were the most toxic, and regarding genotoxicity all groups have had similar results. According to results obtained, we can conclude that EA have similar immediate antimicrobial effect, physical-mechanical properties and toxicity to commercial adhesives, but after six months the microtensile strength was reduced, but similar to commercial references
O objetivo do presente estudo foi avaliar o efeito antimicrobiano e propriedades físico-mecânicas de um adesivo experimental após incorporação de um óleo essencial proveniente da semente de butiá (Butia capitata). Foi formulado um sistema adesivo autocondicionante experimental de dois passos composto por um primer dentinário e um bond (resina de cobertura). O primer foi preparado a partir de quantidades fixas de 2-Hidroxietil metacrilato (HEMA), monômero ácido fosforado e solvente. A resina de cobertura (bond) foi elaborada a partir da mistura homogênea de Bisfenol-A glicidil dimetacrilato (Bis-GMA), Trietilenoglicol dimetacrilato (TEGDMA), HEMA, iniciadores da polimerização como canforoquinona (CQ) e Etil 4-dimetil amino benzoato (EDMAB); e óleo de Butia capitata ( butiá ) 1%. Foram testados três adesivos como referência comercial: Clearfil Protect Bond (CPB), Clearfil SE Bond (CSEB), Adper SE Plus (AP), e dois adesivos experimentais: Adesivo controle sem óleo (AC) e Adesivo experimental contendo óleo de butia (EA). Foram avaliados o efeito antimicrobiano dos adesivos pelo ensaio de inibição da formação de biofilme em monocultura de S. mutans e pela técnica de microcosmos, assim como o desempenho físico-mecânico destes adesivos através dos ensaios de: resistência de união em dentina (μTBS), grau de conversão (DC) e sorção (WS) e solubilidade (SL). Também foi avaliada a biocompatibilidade por meio de ensaios de citotoxidade e genotoxidade. Os dados foram analisados estatisticamente por análises de variância e testes complementares. Na atividade anti-biofilme com monocultura de S. mutans, AP mostrou maior efeito seguido do EA e do CPB. No modelo de microcosmos, maior viabilidade foi encontrado em AC para microrganismos totais e menor viabilidade foi encontrada no C, EA e CPB para acidúricos totais. Já para lactobacilos totais, maior viabilidade foi encontrada no C e AC, e para S. mutans encontramos valores similares em todos os grupos. Para GC, WA, SL e μTBS, o EA foi similar ao AC, porém após 6 meses de envelhecimento os valores de μTBS diminuíram para o EA. Com relação à citotoxidade, o primer do CPB e o Bond do AP foram o mais tóxicos. Para genotoxidade, todos presentaram resultados similares. De acordo com os resultados obtidos, podemos concluir que: o EA teve efeito antimicrobiano, biocompatibilidade e propriedades físico-mecânicas imediatas similares aos comerciais, mas após 6 meses houve diminuição da resistência de união no entanto foi similar as referencias comerciais.
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Vediappan, Rajan Sundaresan. "Modifying Post-Surgical Wound Healing." Thesis, 2021. http://hdl.handle.net/2440/130740.

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“Surgery is a profession defined by its authority to cure by means of bodily invasion. The brutality and risks of opening a living person's body have long been apparent, the benefits only slowly and haltingly worked out”, says Atul Rawande on reviewing 200 yrs. of Surgery as a specialty in NEJM. My research focuses on working out these benefits, specifically looking at reduction of scar tissue formation in ENT, Abdominal & Spine surgery. Scar tissue formation is an outcome of healing process that can be excessive due to inflammation or infection and thereby has the ability to curtail the benefits or warrant revision surgery. Multiple strategies have been tested and employed thus far and none have given favourable results without causing additional harm or economic burden in health care costs. I propose to use a hydrogel synthesized by combining Chitosan and Dextran aldehyde -Chitin is an exoskeleton extracted polymer and Dextran Aldehyde a sugar, with added noveldrugs Deferiprone and Gallium Protoporphyrin providing additional anti scaring and antibiotic properties which could potentially augment the healing properties of the gel. I have conducted 3 types of studies. There are 2 animal studies and a Phase 1 Human clinical trial. The animal studies are an abdominal surgery rat model and a spine surgery sheep model. These studies show the safety and efficacy of this chitogel-drug combination at various dosages and illustrate the healing benefits of gel-drug combination.
Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2021
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Joone, Gisela Käthe. "Die immuunmodulerende eienskappe van oksihumaat : 'n in vivo en in vitro ondersoek (Afrikaans)." Thesis, 2004. http://hdl.handle.net/2263/26739.

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Books on the topic "Anti adhesive agent"

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Kahane, Itzahak. Toward Anti-Adhesion Therapy for Microbial Diseases. Springer, 2011.

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Ofek, Itzhak, and Itzahak Kahane. Toward Anti-Adhesion Therapy for Microbial Diseases. Springer London, Limited, 2012.

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Itzhak, Kahane, Ofek Itzhak, and Bat-Sheva Seminar Toward Anti-Adhesion Therapy of Microbial Diseases (1996 : Zikhron Ya'akov, Israel), eds. Toward anti-adhesion therapy for microbial diseases. New York: Plenum Press, 1996.

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(Editor), N. Bazan, Jack H. Botting (Editor), and Sir John R. Vane (Editor), eds. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules. Springer, 1996.

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Bazan, N., Jack H. Botting, and Sir John R. Vane. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules Proceedings of a Conference Held on April 15-16, 1996, in New Orleans, USA, Supported by an Educational Grant from Boehringer Ingelheim. Springer London, Limited, 2012.

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Bazan, N., Jack H. Botting, and Sir John R. Vane. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules Proceedings of a Conference Held on April 15-16, 1996, in New Orleans, USA, Supported by an Educational Grant from Boehringer Ingelheim. Springer, 2012.

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G, Bazán Nicolás, Botting Jack H, and Vane John R, eds. New targets in inflammation: Inhibitors of COX-2 or adhesion molecules : proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim. Dordrecht: Kluwer Academic Publishers, 1996.

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Book chapters on the topic "Anti adhesive agent"

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Roy, R. "Dendritic and Hyperbranched Glycoconjugates as Biomedical Anti-Adhesion Agents." In Dendrimers and Other Dendritic Polymers, 359–85. Chichester, UK: John Wiley & Sons, Ltd, 2002. http://dx.doi.org/10.1002/0470845821.ch15.

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Schulte, H. G., and R. Höfer. "Uses of anti-foaming agents in paints and surface coatings." In Surfactants in Polymers, Coatings, Inks and Adhesives, 93–119. Blackwell, 2020. http://dx.doi.org/10.1201/9780367812416-4.

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Conference papers on the topic "Anti adhesive agent"

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Miftahurrahmah, Marpaung Willy, Tan Reza Ade, Anati Purwakanthi, and Indah Esa. "The Effects of Human Albumin, Normal Saline and Jambi’s Honey as Anti-Adhesive Agent in Laparotomized Rats." In The 3rd Green Development International Conference (GDIC 2020). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/aer.k.210825.050.

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Sun, Xiaohong, Chibuike Udenigwe, and Songyuan Zhang. "Egg White Ovomucin-derived Glycopeptides as Anti-adhesive Agents Against helicobacter Pylori Infection." In Virtual 2021 AOCS Annual Meeting & Expo. American Oil Chemists’ Society (AOCS), 2021. http://dx.doi.org/10.21748/am21.376.

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Fujimori, T., T. Saeki, K. Harada, M. Sato, and N. Ohshima. "ANTI-THROMBOTIC EFFECTS OF E-5510 IN EXPERIMENTAL THROMBOSIS MODELS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643429.

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A new agent developed in our laboratory, 4-cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid (E-5510), suppressed various human platelet functions in vitro. The compound also showed quite potent ex vivo anti-platelet effects in many experimentalanimals. It is well known that anti-platelet effects are not always parallel to anti-thrombotic effects. Thus, in order to predict the efficacy of E-5510 in thrombotic disorders, the anti-thrombotic effects were examined in 3 different animal models of thrombosis.(1) Anti-thrombotic effect in an extracorporeal shunt model Two hrs after oral administration of the drug to guinea pigs,an extracorporeal shunt between the right carotid artery and the left jugular vein was performed. The thrombus formation on a silk thread inserted in the shunt tube was quantitated by measuring the time from the onset of circulation to the stenosis of blood flow. E-5510 dose-dependently inhibited thrombus formation, the minimum effective dose being 0.03 mg/kg.(2) Effect on microthrombus formation in mesenteric arteriole In order to evaluate the effect on intravascular platelet thrombus formation, thrombosis was induced in vivo in mesenteric arteriole in guinea pigs with filtered light from a mercury lamp and an intravenous fluorescent dye in an intravital microscope system (M. Sato and N. Ohshima, Thromb. Res.,35, 319, 1984). The thrombus formation was quantitated by measuring the time taken for circulating platelets to begin to adhere to vessel wall and the time taken for blood flow to stop completely due to fully developed thrombus. Both the time required for platelet adhesion to vessel wall and for platelet thrombus formation were significantly prolonged after oral administration of E-5510.(3) Effect on pulmonary thromboembolism Acute pulmonary thromboembolism was induced in mice by a bolus intravenous injection of arachidonic acid, and mortality was determined 3 min later. E-5510 dose-dependently reduced pulmonary thromboembolic mortality, and its ED50 was 0.11 mg/kg. The results described above indicate thatE-5510 may have beneficial effects in clinical treatments of thrombotic disease.
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Liu, Xiaowen, Tianyu Cai, Wanjing Ding, Chong Zhang, Yuchen Zhao, Hong Zhu, Yanfei Shao, Qiaojun He, and Bo Yang. "Abstract 3598: Targeting b1 integrin, celastrol as a potent anti-metastatic agent, inhibits cell-ECM adhesion, partially via the p38 MAPK pathway." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3598.

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