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Journal articles on the topic 'Antemortem records'
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Thampan, Niveditha, R. Janani, R. Ramya, R. Bharanidharan, ARamesh Kumar, and K. Rajkumar. "Antemortem dental records versus individual identification." Journal of Forensic Dental Sciences 10, no. 3 (2018): 158. http://dx.doi.org/10.4103/jfo.jfds_13_18.
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Srivastava, Chhavi, M. K. Sunil, Upender Malik, and Surangama Lehri. "Dental Records- The X-factor for Forensic Odontologists." Journal of Indo Pacific Academy of Forensic Odontology. 10, no. 01 (May 25, 2020): 1–4. http://dx.doi.org/10.53275/inapfo.2231-1092-2231-15721011.
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Clinical record keeping is the core component of good and quality practice. Dental records provide characteristic features of an individual and thus aids in forensic investigations. A thorough habit of maintaining dental records, also gives an edge in the legal matters such as personal identification by antemortem records, age estimation, insurance etc.Therefore, this article gives an overview about the dental records and their role in forensic investigations.
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Richmond, Raymond, and Iain A. Pretty. "Antemortem Records of Forensic Significance Among Edentulous Individuals." Journal of Forensic Sciences 52, no. 2 (March 2007): 423–27. http://dx.doi.org/10.1111/j.1556-4029.2006.00378.x.
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Thorn, Jennifer L., Kevin B. Gilchrist, Richard E. Sobonya, Nand K. Gaur, Peter N. Lipke, and Stephen A. Klotz. "Postmortem candidaemia: marker of disseminated disease." Journal of Clinical Pathology 63, no. 4 (November 25, 2009): 337–40. http://dx.doi.org/10.1136/jcp.2009.070607.
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AimThe significance of finding Candida species in heart blood cultures obtained at postmortem examination has never been studied. This article describes the findings of autopsy patients with postmortem candidaemia and it compares them with findings in autopsy patients with antemortem candidaemia.Method23 patients with Candida species isolated from heart blood at autopsy were identified over a 10-year period. These patients were compared with 10 autopsy patients found during the same time period with antemortem blood cultures isolating Candida species, but not positive postmortem heart blood cultures. Antemortem and postmortem records were reviewed.ResultsAll 23 patients with Candida species isolated from postmortem blood culture had one or more antemortem risk factors for disseminated candidiasis, such as positive antemortem blood cultures, isolation of Candida from sterile internal sites, neutropenia, recent abdominal surgery, broad-spectrum antibiotic administration or the use of central venous catheters or other invasive devices. Eight patients showed histological proof of invasive candidiasis in addition to the positive heart blood cultures. This group did not differ with respect to risk factors from 10 autopsy patients with disseminated candidiasis and antemortem blood cultures with Candida species. However, all the patients with antemortem candidaemia had histological evidence of disseminated candidiasis at autopsy.ConclusionCandidaemia, when documented by heart blood culture performed at autopsy or by antemortem blood culture, is an insensitive, but highly specific, indicator of disseminated candidiasis.
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Delattre, Veronique F. "Antemortem Dental Records: Attitudes and Practices of Forensic Dentists." Journal of Forensic Sciences 52, no. 2 (March 2007): 420–22. http://dx.doi.org/10.1111/j.1556-4029.2006.00379.x.
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Singh, Rishabh Kumar, Sunil Duchania, and Mukta Rani. "Sternal foramen- Incidence and medico-legal importance." IP International Journal of Forensic Medicine and Toxicological Sciences 6, no. 4 (January 15, 2022): 137–40. http://dx.doi.org/10.18231/j.ijfmts.2021.029.
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Sternum foramen may be misinterpreted as acquired lesions such as gunshot wound, fracture, lytic lesions, etc. Sternal foramen leaves the lung, heart and large vessels unprotected while performing invasive procedures such as bone marrow aspiration, acupuncture leading to life-threatening complications such as pneumothorax and cardiac tamponade. From a medicolegal perspective, identifying the morphological anomalies or variations of xiphoid process aid in the individualization process by serving as points of similarity when their occurrence has been recorded antemortem. In addition, their antemortem records in the form of previous x rays make important data for skeletonized remains to be identified.The present study was carried using sternal bones removed during autopsy on a total of 350 cases above the age of 30 years and has established aincidence of 6.57% for sternal foramen.Forensic pathologists should be meticulous enough to rule out errors in determining the nature and cause of death in worrying cases as sternal foramen is highly likely to be confused with gun-shot wounds or traumatic antemortem injury.
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Knivsberg, Ina C., Simen E. Kopperud, Mai-Britt Bjørk, Gerald Torgersen, Katarzyna Skramstad, and Sigrid I. Kvaal. "Digitalised exercise material in forensic odontology." International Journal of Legal Medicine 136, no. 1 (November 20, 2021): 381–90. http://dx.doi.org/10.1007/s00414-021-02740-7.
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Abstract Introduction This paper presents digital educational material in forensic odontology, including dental identification after multiple fatalities and dental age estimation from different age groups. Material and method Electronic patient records consisting of intraoral scans of the dentition, digital radiographs, photographs and written dental records were collected. Exercises in age estimations contained digital radiographs and photographs of ground tooth sections, with digital measuring tools and tables according to age groups. The teaching material was organised as a module in an electronic Learning Management System with external links to all relevant teaching material. Results For the identification exercises, intraoral scans and the latest digital radiographs simulated the postmortem examination of the deceased. For comparison, all other radiographs, photographs and dental records were available as antemortem material. The exercise was to match postmortem findings with the antemortem records using the Interpol standard and reconciliation. Age assessment of children used designated tables to grade tooth development on digital radiographs. For adults, non-destructive methods, digital radiographs, photographs and measuring tools were used. Discussion The teaching concept was hybrid, but it can easily be adapted as a fully digital exercise. The instructions and written material can be translated into different languages. The level of difficulty in the exercises can be adjusted according to the participant’s level of knowledge. Conclusion The educational material embraces the new possibilities for digitalisation and intraoral scanning. This might be a valuable tool for motivating and engaging the students in their participation and understanding of the subject.
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Scott, Audrey L., Derek Congram, David Sweet, Stephen Fonseca, and Mark Skinner. "Anthropological and Radiographic Comparison of Antemortem Surgical Records for Identification of Skeletal Remains." Journal of Forensic Sciences 55, no. 1 (January 2010): 241–44. http://dx.doi.org/10.1111/j.1556-4029.2009.01203.x.
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de Cosmo, Sergio, and Joseph A. Barbera. "Rapid Disaster Victim Identification in Mass Fatality Incidents: Decision-Support Tool to Facilitate Human Remains Identification." Disaster Medicine and Public Health Preparedness 6, no. 3 (October 2012): 277–90. http://dx.doi.org/10.1001/dmp.2012.44.
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ABSTRACTObjectives:A quantitative decision-support tool (DST), using a combination of selected human physical attributes as identification elements, was developed to facilitate body identification in mass fatality incidents, particularly in settings with limited availability of technological resources and forensic expertise.Methods:To construct the DST, the external biological attributes of interest were first selected. A process was then developed to guide collection of the selected categories of attributes and record them into objective antemortem (AM) and postmortem (PM) records. Finally, a framework for assessing the similarity between confronting PM-AM attribute records was established. The DST evaluates the similarities between each set of like attributes in the AM and PM records being compared. It then computes an overall similarity score for each evaluated AM record that was compared to a selected PM record. The AM record with the highest score represents the highest probable match, with the PM file selected for the comparison.Results:Multiple simulations across a range of mass fatality situations demonstrated the effectiveness of the DST in the experimental setting.Conclusions:The developed DST may provide authorities with a method for expediting body identification without completely eliminating any missing person file from consideration. Under specific circumstances, this method may reduce the need for technologically sophisticated forensic identification techniques (eg, dental records, fingerprints, and DNA). At a minimum, it should facilitate the efficiency of the current technological matching process.(Disaster Med Public Health Preparedness. 2012;6:277–290)
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Blau, Soren, Anthony Hill, Christopher A. Briggs, and Stephen M. Cordner. "Missing Persons-Missing Data: The Need to Collect Antemortem Dental Records of Missing Persons." Journal of Forensic Sciences 51, no. 2 (March 2006): 386–89. http://dx.doi.org/10.1111/j.1556-4029.2006.00051.x.
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Sallis, Claire, and Scheila Mânica. "Comparative dental analysis: should dentists release dental records?" Dental Update 48, no. 2 (February 2, 2021): 148–51. http://dx.doi.org/10.12968/denu.2021.48.2.148.
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Comparative dental analysis is the main role of a UK forensic dentist. It is undertaken to determine whether postmortem findings are in agreement with the provided antemortem data for an individual, in order to achieve a positive identification. It requires dentists to maintain accurate dental records and, when a confirmatory identification is required, to breach their confidentiality obligations to their patients. Several different dental records can prove helpful during the process, which are outlined in a novel checklist designed to guide both practitioners and law enforcement officers. It is supported by the UK Missing Persons Unit and the British Association of Forensic Odontology (BAFO) and is available to download in a PDF format from dentalidrecordchecklist.com. CPD/Clinical Relevance: All dental practitioners should be aware of forensic dentistry as a specialism and how they may be required to help during a human identification. Understanding the principles of comparative dental analysis should be attained, thus recognizing the importance of releasing dental records, preventing delays and uncertainty around breaching confidentiality obligations.
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Bennett, PF, KA Hahn, RL Toal, and AM Legendre. "Ultrasonographic and cytopathological diagnosis of exocrine pancreatic carcinoma in the dog and cat." Journal of the American Animal Hospital Association 37, no. 5 (September 1, 2001): 466–73. http://dx.doi.org/10.5326/15473317-37-5-466.
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This study describes the ultrasonographic and cytopathological characteristics of malignant neoplasms of the exocrine pancreas and their value in making an antemortem diagnosis. The medical records of eight dogs and five cats were reviewed. The clinical presentations were variable and at times mimicked pancreatitis. Overall, cytopathology of ultrasound or fluoroscopic-guided biopsies or fine-needle aspirates, or impressions from surgical biopsies were helpful in establishing the diagnosis in 10 of 12 animals where it was performed. Histopathology of ultrasound or fluoroscopic-guided biopsies provided a diagnosis in five of six cases where it was performed.
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Lanjewar, Dhaneshwar Namdeorao, Nikita Subhash Sheth, Sonali Dhaneshwar Lanjewar, and Ulhas Laxman Wagholikar. "Analysis of Causes of Death as Determined at Autopsy in a Single Institute, The Grant Medical College and Sir J. J. Hospital, Mumbai, India, Between 1884 and 1966: A Retrospective Analysis of 13 024 Autopsies in Adults." Archives of Pathology & Laboratory Medicine 144, no. 5 (July 31, 2019): 644–49. http://dx.doi.org/10.5858/arpa.2018-0229-hp.
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Context.— Grant Medical College and Sir J. J. Hospital, Mumbai (India), have a long tradition of clinical autopsies, wherein autopsy records have existed since 1884. The old autopsy records from 1884 to 1966 were discovered during a refurbishing drive of the pathology department in 2007. Objective.— To know the relative causes of deaths in Sir J. J. Hospital Mumbai from 1884 through 1966. To determine the rate of antemortem and postmortem discrepancies in the prehistology and posthistology era. Design.— The reports of clinical autopsies in the archives of the Department of Pathology from January 1884 to December 1966 were reviewed. Data such as sex, age, and clinical and autopsy diagnoses were collected, based on the autopsy records of 13 024 patients. Results.— Of 13 024 patients, 10 197 (78%) were male and 2827 (22%) were female. Most deaths (55%) involved individuals ages 21 to 40 years. Infections were the cause of death in 7281 of 13 024 patients (56%), followed by cardiovascular diseases in 2138 (16%) and neoplasms in 963 (7%). The overall disagreement between clinical diagnoses and postmortem findings was 4105 of 13 024 patients (31%). Discrepancy between antemortem and postmortem diagnoses in the prehistology era (before 1950) was found in 3053 of 8951 patients (34%), whereas in the posthistology era (after 1950), discrepancy was found in 1019 of 4073 patients (25%). Conclusions.— Historical collections provide baseline data against which modern observations can be compared. Such collections also offer a window on the past and often provide a less biased account of events. Historical collections of museum materials such as ours are valuable because they can serve as potential biorepository materials to facilitate future research. Apart from providing reliable data on the occurrence of diseases, the autopsy has an important role in providing information about conditions that are no longer prevalent. Medical institutes possessing old autopsy records, wet specimens, paraffin blocks, and slides should preserve such historical collections.
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Sohail, Aqib, Nighat Zahid, Aneela Amjad, Fareed Ud Din Chishti, Uzair Abu Bakar, and Fizzah Ali. "Receptiveness of Maintaining Dental Records for Forensic and Other Matters." Pakistan Journal of Medical and Health Sciences 15, no. 8 (August 26, 2021): 1988–92. http://dx.doi.org/10.53350/pjmhs211581988.
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Background: Dental records assume a significant part as these might be utilized in identification of dead or missing humans, as proof in court and in criminological dentistry as discoveries of posthumous assessments are contrasted with antemortem dental evidence that have been well-maintained. Aim: To evaluate the awareness regarding significance of dental records and receptiveness of the practitioner toward maintenance in proper pattern. Method: This cross sectional descriptive was carried out between September and December, 2019 at established dental institution of Lahore. A questionnaire containing 16 close ended question was formulated and distributed to all the participants. We seek approval from ethical committee of Lahore Medical & Dental College. Statistics was investigated through SPSS version 20; Pearson correlation coefficient was utilized. Results: A total of 350 dental practitioners took part in this study, statistics revealed that 68.3 % were familiar with importance of maintaining records. Though 96 % dental professionals record the full name, age and gender of patients, 94% explore medical history, 78% record various developmental dental anomalies and 39 % notice decayed, missed or filled teeth; but in general 55.4% percent maintain the patient-related correspondence. Amongst them 33.5% of dental professionals preserve the dental file, 40% percent conserve the radiographs, 29% photographs of the patients, and just 10% of the dentists preserve the casts. Duration of conserving dental records found inconstant; 40% sustain all the patient-related correspondence for a month or less, 21.20 % for a half year, 18.4 % for a year, 6.4% as long as 5 years and just 1 % for around 10 years. Conclusion: Information and receptiveness of maintaining records among the dental professionals of Lahore is inadequate, improvement can be accomplished by education and training. Keywords: dental records, identification, forensic dentistry, patient chart
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McDermott, Colin T., Charles J. Innis, Akinyi C. Nyaoke, Kathryn A. Tuxbury, Julie M. Cavin, E. Scott Weber, Deana Edmunds, et al. "Phaeohyphomycosis due to Exophiala in Aquarium-Housed Lumpfish (Cyclopterus lumpus): Clinical Diagnosis and Description." Pathogens 11, no. 12 (November 23, 2022): 1401. http://dx.doi.org/10.3390/pathogens11121401.
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Phaeohyphomycosis caused by Exophiala species represents an important disease of concern for farmed and aquarium-housed fish. The objective of this study was to summarize the clinical findings and diagnosis of Exophiala infections in aquarium-housed Cyclopterus lumpus. Clinical records and postmortem pathology reports were reviewed for 15 individuals from 5 public aquaria in the United States and Canada from 2007 to 2015. Fish most commonly presented with cutaneous ulcers and progressive clinical decline despite topical or systemic antifungal therapy. Antemortem fungal culture of cutaneous lesions resulted in colonial growth for 7/12 samples from 8 individuals. Amplification of the internal transcribed spacer region (ITS) of nuclear rDNA identified Exophiala angulospora or Exophiala aquamarina in four samples from three individuals. Postmortem histopathologic findings were consistent with phaeohyphomycosis, with lesions most commonly found in the integument (11/15), gill (9/15), or kidney (9/15) and evidence of fungal angioinvasion and dissemination. DNA extraction and subsequent ITS sequencing from formalin-fixed paraffin-embedded tissues of seven individuals identified E. angulospora, E. aquamarina, or Cyphellophora sp. in four individuals. Lesion description, distribution, and Exophiala spp. identifications were similar to those reported in farmed C. lumpus. Antemortem clinical and diagnostic findings of phaeohyphomycosis attributable to several species of Exophiala provide insight on the progression of Exophiala infections in lumpfish that may contribute to management of the species in public aquaria and under culture conditions.
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Spence, Michael W., Christine D. White, and Fred J. Longstaffe. "AN ARCHAEOLOGY OF CERRO PORTEZUELO BIOARCHAEOLOGY: BURIAL ANALYSIS AND THE (RE)EXCAVATION OF CONTEXTS FROM A 1950s PROJECT." Ancient Mesoamerica 24, no. 1 (2013): 185–99. http://dx.doi.org/10.1017/s0956536113000102.
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AbstractOnly about 19 of the 70 or so skeletons excavated at Cerro Portezuelo were brought back to UCLA, and adequate information is lacking for most of these. A detailed analysis of the excavation and curation records, as well as of the skeletons, was conducted in an attempt to identify their contexts and to evaluate their potential for contribution to our knowledge of the Cerro Portezuelo community. Although subadult dental health was good, adult levels of caries and antemortem loss were comparable to those of other Mesoamerican populations. Oxygen-isotope data suggest only limited long-distance immigration into the area. Further interpretation, however, is hampered by poor contextual data and the inability to assign most individuals to a specific period.
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Wadhwani, Surbhi, Pushparaja Shetty, and SV Sreelatha. "Maintenance of antemortem dental records in private dental clinics: Knowledge, attitude, and practice among the practitioners of Mangalore and surrounding areas." Journal of Forensic Dental Sciences 9, no. 2 (2017): 78. http://dx.doi.org/10.4103/jfo.jfds_64_15.
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Uretsky, Madeline, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Z. Mian, et al. "Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts." Neurology 98, no. 1 (November 24, 2021): e27-e39. http://dx.doi.org/10.1212/wnl.0000000000013012.
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Background and ObjectivesLate neuropathologies of repetitive head impacts from contact sports can include chronic traumatic encephalopathy (CTE) and white matter degeneration. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) MRI scans are often viewed as microvascular disease from vascular risk, but might have unique underlying pathologies and risk factors in the setting of repetitive head impacts. We investigated the neuropathologic correlates of antemortem WMH in brain donors exposed to repetitive head impacts. The association between WMH and repetitive head impact exposure and informant-reported cognitive and daily function were tested.MethodsThis imaging–pathologic correlation study included symptomatic male decedents exposed to repetitive head impacts. Donors had antemortem FLAIR scans from medical records and were without evidence of CNS neoplasm, large vessel infarcts, hemorrhage, or encephalomalacia. WMH were quantified using log-transformed values for total lesion volume (TLV), calculated using the lesion prediction algorithm from the Lesion Segmentation Toolbox. Neuropathologic assessments included semiquantitative ratings of white matter rarefaction, cerebrovascular disease, hyperphosphorylated tau (p-tau) severity (CTE stage, dorsolateral frontal cortex), and β-amyloid (Aβ). Among football players, years of play was a proxy for repetitive head impact exposure. Retrospective informant-reported cognitive and daily function were assessed using the Cognitive Difficulties Scale (CDS) and Functional Activities Questionnaire (FAQ). Regression models controlled for demographics, diabetes, hypertension, and MRI resolution. Statistical significance was defined as p ≤ 0.05.ResultsThe sample included 75 donors: 67 football players and 8 nonfootball contact sport athletes or military veterans. Dementia was the most common MRI indication (64%). Fifty-three (70.7%) had CTE at autopsy. Log TLV was associated with white matter rarefaction (odds ratio [OR] 2.32, 95% confidence interval [CI] 1.03, 5.24; p = 0.04), arteriolosclerosis (OR 2.38, 95% CI 1.02, 5.52; p = 0.04), CTE stage (OR 2.58, 95% CI 1.17, 5.71; p = 0.02), and dorsolateral frontal p-tau severity (OR 3.03, 95% CI 1.32, 6.97; p = 0.01). There was no association with Aβ. More years of football play was associated with log TLV (unstandardized β 0.04, 95% CI 0.01, 0.06; p = 0.01). Greater log TLV correlated with higher FAQ (unstandardized β 4.94, 95% CI 0.42, 8.57; p = 0.03) and CDS scores (unstandardized β 15.35, 95% CI −0.27, 30.97; p = 0.05).DiscussionWMH might capture long-term white matter pathologies from repetitive head impacts, including those from white matter rarefaction and p-tau, in addition to microvascular disease. Prospective imaging–pathologic correlation studies are needed.Classification of EvidenceThis study provides Class IV evidence of associations between FLAIR white matter hyperintensities and neuropathologic changes (white matter rarefaction, arteriolosclerosis, p-tau accumulation), years of American football play, and reported cognitive symptoms in symptomatic brain donors exposed to repetitive head impacts.
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Chiricosta, Luigi, Simone D’Angiolini, Agnese Gugliandolo, and Emanuela Mazzon. "Artificial Intelligence Predictor for Alzheimer’s Disease Trained on Blood Transcriptome: The Role of Oxidative Stress." International Journal of Molecular Sciences 23, no. 9 (May 7, 2022): 5237. http://dx.doi.org/10.3390/ijms23095237.
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Alzheimer’s disease (AD) is an incurable neurodegenerative disease diagnosed by clinicians through healthcare records and neuroimaging techniques. These methods lack sensitivity and specificity, so new antemortem non-invasive strategies to diagnose AD are needed. Herein, we designed a machine learning predictor based on transcriptomic data obtained from the blood of AD patients and individuals without dementia (non-AD) through an 8 × 60 K microarray. The dataset was used to train different models with different hyperparameters. The support vector machines method allowed us to reach a Receiver Operating Characteristic score of 93% and an accuracy of 89%. High score levels were also achieved by the neural network and logistic regression methods. Furthermore, the Gene Ontology enrichment analysis of the features selected to train the model along with the genes differentially expressed between the non-AD and AD transcriptomic profiles shows the “mitochondrial translation” biological process to be the most interesting. In addition, inspection of the KEGG pathways suggests that the accumulation of β-amyloid triggers electron transport chain impairment, enhancement of reactive oxygen species and endoplasmic reticulum stress. Taken together, all these elements suggest that the oxidative stress induced by β-amyloid is a key feature trained by the model for the prediction of AD with high accuracy.
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Cheong, I., P. J. Flegg, R. P. Brettle, P. D. Welsby, S. M. Burns, B. Dhillon, C. L. S. Leen, and J. A. Gray. "Cytomegalovirus Disease in AIDS: The Edinburgh Experience." International Journal of STD & AIDS 3, no. 5 (September 1992): 324–28. http://dx.doi.org/10.1177/095646249200300504.
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Retrospective analysis of medical records of 557 HIV positive patients (including 113 with AIDS) revealed 17 patients with an antemortem clinical diagnosis of cytomegalovirus (CMV) disease. This group comprised 7 injection drug users (2 male and 5 female) and 10 homosexual men. Males were significantly older than females, and homosexual men were significantly older than drug users at the time of diagnosis of CMV. All 17 patients had evidence of retinitis, and 6 also had evidence of extraocular disease. CMV retinitis was the AIDS defining diagnosis in two patients, and the attack rate of CMV in all AIDS patients progressively increased with time, with a 3-year CMV-free survival of 57%. Fifteen patients with CMV disease had evidence of previous CMV infection (CMV IgG positive), with 7 also having a positive CMV IgM and 10 a positive viral culture. The mean CD4+ lymphocyte count at diagnosis of CMV was 17 cells/mm3, compared with 68 cells/mm3 at diagnosis of AIDS. Therapy was unsatisfactory, often being complicated by marrow suppression. Relapse occurred in 11 patients after initial improvement but despite this only 3 patients died with severe visual impairment. The mean survival after a diagnosis of CMV was 10.5 months. This study confirms that disease caused by CMV is usually a late manifestation of AIDS, and the increasing prevalence among patients with AIDS implies that, the longer the survival, the greater the risk of disease. Frequent fundoscopy in HIV positive patients is of paramount importance particularly in patients who have a CD4+ lymphocyte count of less than 100 cells/mm3.
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Putrino, Alessandra, Valerio Bruti, Marinelli Enrico, Ciallella Costantino, Barbato Ersilia, and Galluccio Gabriella. "Intraoral Scanners in Personal Identification of Corpses: Usefulness and Reliability of 3D Technologies in Modern Forensic Dentistry." Open Dentistry Journal 14, no. 1 (June 16, 2020): 255–66. http://dx.doi.org/10.2174/1874210602014010255.
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Aims: This study aims to verify the applicability of modern dental technologies and their related principles of use to the forensic sciences in the field of personal identification. Background: Personal identification has always had a major role in many legal and administrative actions regarding both living and death beings. The techniques used are much less advanced than the technologies potentially available. Objective: Modern technologies, available to the daily dental clinic practice, as intraoral scanners, combined in particular to the specialist skill in orthodontics, can help redefine the methods of personal identification according to the levels of accuracy, trueness and feasibility greater than those applied in traditional forensic dentistry. Methods: 23 corpses (12F;11M) have been selected for intraoral scanning with the Carestream 3500® digital device. The superimposition of initial and late digital models, digital models and radiographs (orthopantomography and full mouth periapical films) has been evaluated to verify the stability of some structures as palatal rugae after death and to assess intraoral scanning as a successful comparative method between antemortem and post-mortem records (digital models or radiographs). Obtained results were subjected to statistical analysis by the t-student test and X-square test with Yates correction (p<0.05). Results: After death, palatal rugae significatively change especially in mouths with restorations/prosthesis/missing teeth. The percentages of correct matching between scans and radiographs are very higher (up 90%; p<0.05). Conclusion: This study has been set up to study and develop new, reliable and fast methods of personal identification that can surpass many of the issues seen with the other techniques by a modern rugoscopy, a modern radiographic-digital comparison and virtual oral autopsy.
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Putrino, Alessandra, Valerio Bruti, Marinelli Enrico, Ciallella Costantino, Barbato Ersilia, and Galluccio Gabriella. "Intraoral Scanners in Personal Identification of Corpses: Usefulness and Reliability of 3D Technologies in Modern Forensic Dentistry." Open Dentistry Journal 14, no. 1 (June 16, 2020): 305–16. http://dx.doi.org/10.2174/1874210602014010305.
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Aims: This study aims to verify the applicability of modern dental technologies and their related principles of use to the forensic sciences in the field of personal identification. Background: Personal identification has always had a major role in many legal and administrative actions regarding both living and death beings. The techniques used are much less advanced than the technologies potentially available. Objective: Modern technologies, available to the daily dental clinic practice, as intraoral scanners, combined in particular to the specialist skill in orthodontics, can help redefine the methods of personal identification according to the levels of accuracy, trueness and feasibility greater than those applied in traditional forensic dentistry. Methods: 23 corpses (12F;11M) have been selected for intraoral scanning with the Carestream 3500® digital device. The superimposition of initial and late digital models, digital models and radiographs (orthopantomography and full mouth periapical films) has been evaluated to verify the stability of some structures as palatal rugae after death and to assess intraoral scanning as a successful comparative method between antemortem and post-mortem records (digital models or radiographs). Obtained results were subjected to statistical analysis by the t-student test and X-square test with Yates correction (p<0.05). Results: After death, palatal rugae significatively change especially in mouths with restorations/prosthesis/missing teeth. The percentages of correct matching between scans and radiographs are very higher (up 90%; p<0.05). Conclusion: This study has been set up to study and develop new, reliable and fast methods of personal identification that can surpass many of the issues seen with the other techniques by a modern rugoscopy, a modern radiographic-digital comparison and virtual oral autopsy.
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Eto, Nozomi, Junichi Yamazoe, Akiko Tsuji, Naohisa Wada, and Noriaki Ikeda. "Development of an artificial intelligence-based algorithm to classify images acquired with an intraoral scanner of individual molar teeth into three categories." PLOS ONE 17, no. 1 (January 7, 2022): e0261870. http://dx.doi.org/10.1371/journal.pone.0261870.
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Background Forensic dentistry identifies deceased individuals by comparing postmortem dental charts, oral-cavity pictures and dental X-ray images with antemortem records. However, conventional forensic dentistry methods are time-consuming and thus unable to rapidly identify large numbers of victims following a large-scale disaster. Objective Our goal is to automate the dental filing process by using intraoral scanner images. In this study, we generated and evaluated an artificial intelligence-based algorithm that classified images of individual molar teeth into three categories: (1) full metallic crown (FMC); (2) partial metallic restoration (In); or (3) sound tooth, carious tooth or non-metallic restoration (CNMR). Methods A pre-trained model was created using oral-cavity pictures from patients. Then, the algorithm was generated through transfer learning and training with images acquired from cadavers by intraoral scanning. Cross-validation was performed to reduce bias. The ability of the model to classify molar teeth into the three categories (FMC, In or CNMR) was evaluated using four criteria: precision, recall, F-measure and overall accuracy. Results The average value (variance) was 0.952 (0.000140) for recall, 0.957 (0.0000614) for precision, 0.952 (0.000145) for F-measure, and 0.952 (0.000142) for overall accuracy when the algorithm was used to classify images of molar teeth acquired from cadavers by intraoral scanning. Conclusion We have created an artificial intelligence-based algorithm that analyzes images acquired with an intraoral scanner and classifies molar teeth into one of three types (FMC, In or CNMR) based on the presence/absence of metallic restorations. Furthermore, the accuracy of the algorithm reached about 95%. This algorithm was constructed as a first step toward the development of an automated system that generates dental charts from images acquired by an intraoral scanner. The availability of such a system would greatly increase the efficiency of personal identification in the event of a major disaster.
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Iwen, Peter C., Elizabeth C. Reed, James O. Armitage, Philip J. Bierman, Anne Kessinger, Julie M. Vose, Mark A. Arneson, Barbara A. Winfield, and Gail L. Woods. "Nosocomial Invasive Aspergillosis in Lymphoma Patients Treated with Bone Marrow or Peripheral Stem Cell Transplants." Infection Control & Hospital Epidemiology 14, no. 3 (March 1993): 131–39. http://dx.doi.org/10.1086/646698.
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AbstractObjectives:To determine the prevalence of aspergillosis in lymphoma patients housed in a protective environment while undergoing a bone marrow transplant or peripheral stem cell transplant and its relation to lymphoma type, type of transplant, period of neutropenia, method of diagnosis, species of Aspergillus, and the use of empiric amphotericin B.Design:Clinical, autopsy, and microbiology records were reviewed retrospectively to determine the presence or absence of invasive aspergillosis. All positive specimens underwent further review to determine parameters outlined above.Setting:The review took place at the University of Nebraska Medical Center with lymphoma patients housed in the oncology/hematology special care unit, which consists of 30 single-patient rooms under positive pressure with high-efficiency particulate air filtration.Patients:4 17 lymphoma patients admitted to the oncology/hematology special care unit who underwent 427 courses of high-dose chemotherapy with or without total body irradiation followed by a stem cell rescue.Results:Twenty-two cases (5.2%) of nosocomial invasive aspergillosis (14 caused by Aspergillus flavus, 2 by Aspergillus terreus, 2 by Aspergillus fumigatus, and 4 by characteristic histology) were diagnosed. The prevalence of disease according to transplant was 8.7% for allogeneic bone marrow transplant (2/23 treatments), 5.6% for autologous peripheral stem cell transplant (9/161), and 4.5% for autologous bone marrow transplant (11/243). Fifteen patients were presumptively diagnosed prior to death (68.2%) most commonly by histologic examination of skin biopsies. All 22 patients received amphotericin B therapy, 17 prior to aspergillosis diagnosis, and 7 (31.8%) survived. No patient with disseminated disease survived.Conclusions:Even when housing lymphoma patients undergoing myeloablative therapy in a protective environment containing high-efficiency particulate air filtration, there was a risk of developing aspergillosis. These data also showed that antemortem diagnosis with aggressive amphotericin B therapy was most effective in the management of infected lymphoma patients when engraftment occurred and the disease did not become disseminated.
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Bayer-Garner, Ilene B., Louis M. Fink, and Laura W. Lamps. "Pathologists in a Teaching Institution Assess the Value of the Autopsy." Archives of Pathology & Laboratory Medicine 126, no. 4 (April 1, 2002): 442–47. http://dx.doi.org/10.5858/2002-126-0442-piatia.
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Abstract Context.—With the advent of modern diagnostic technology, use of the autopsy as a means of assessing diagnostic accuracy has declined precipitously. Interestingly, during the same period, the rate of misdiagnosis found at autopsy has not changed. Objectives.—To ascertain why an autopsy was requested, whether or not questions asked by clinicians were specifically addressed, and what types of misdiagnoses were found. Design.—One hundred forty-two consecutive autopsy records from the University of Arkansas for Medical Sciences Hospital were reviewed. In the same period, 715 deaths occurred, giving an overall autopsy rate of 20.14%. Results.—Of the 125 autopsies in which the problem-oriented autopsy request was available for review, a reason for the autopsy was given in only 69 cases (55%). One hundred three clinical questions were asked, and of these, 81 were specifically addressed in the final anatomic diagnosis, 10 were addressed in some part of the autopsy report but not in the final anatomic diagnosis, 10 were not addressed at all, and 2 could not be answered by the autopsy. Sixty-one autopsies revealed 81 misdiagnoses: 47 class I (missed major diagnosis that, if detected before death, could have led to a change in management that might have resulted in cure or prolonged survival) and 34 class II misdiagnoses (missed major diagnosis in which antemortem detection would have not led to a change in management). Conclusions.—The autopsy continues to be a vital part of medical education and quality assurance. It is important for the clinician to provide a clinical summary and specific clinical questions to be addressed or to speak directly with the pathologist and for the pathologist to provide answers that are easily accessible within the autopsy report. In this way, a problem-oriented autopsy can be performed based on questions raised by the clinician and the pathologist as a result of the gross dissection and microscopic evaluation.
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Kumar, Surender, Sonali Singh, and Nitika Bhardwaj. "Diatomological mapping of water bodies of Delhi region for forensic consideration." Indian Journal of Forensic and Community Medicine 9, no. 4 (January 15, 2023): 173–77. http://dx.doi.org/10.18231/j.ijfcm.2022.036.
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Diatoms are photosynthetic algae; having a siliceous cell wall known as ‘frustule’. They are abundantly found in every aquatic and terrestrial environment including both fresh and marine water. They are cosmopolitan in nature as these microalgal species are also capable of growing on moist substrates like soil and bark of a plant. The growth of diatoms is very specific to the environmental conditions of a place due to which they are regarded as principal indicators of ecological status of the ecosystem. In forensics also, they play a crucial role in determining the mode and manner of death in cases of drowning. These small entities act as supportive evidence to detect the type of drowning; whether the death of a victim was due to antemortem or postmortem drowning. The diatomological mapping (D-mapping) of water bodies is an essential feature to generate a systematic record of diatom diversity present at a particular site of an aquatic body. The aim of our study is to conduct D-mapping of several regions of Delhi in order to generate a systematic record of diatoms present therein. The results of our study showed about 20 diatom species, some of them were commonly present at all sites, whereas few among them were site specific. The diatom database generated from D-mapping of water bodies can be used as a reference by the forensic pathologists while solving drowning cases, if any, from these aquatic bodies.
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Gilmore, Cassandra C. "A comparison of antemortem tooth loss in human hunter-gatherers and non-human catarrhines: Implications for the identification of behavioral evolution in the human fossil record." American Journal of Physical Anthropology 151, no. 2 (May 2, 2013): 252–64. http://dx.doi.org/10.1002/ajpa.22275.
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Dr. Gutta Mounika, Dr. Bonthagarla Krishna Sahi, Dr. A.D.N Deepika, Dr. Naidu Harika, and Dr. Avuluri Malyadri. "PALATAL RUGAE PATTERN IN GENDER IDENTIFICATION - A FORENSIC STUDY." International Journal of Forensic Odontology 7, no. 1 (July 13, 2022): 47–57. http://dx.doi.org/10.56501/intjforensicodontol.v7i1.175.
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Background: Palatal rugae pattern is reasonably unique to an individual and remain stable throughout lifetime. It can serve as an important tool in forensic identification particularly when other regular methods of identification become difficult.Aim: To evaluate the palatal rugae pattern between both gender in terms of Number, Shapes and Length on right and left sides among different age groups.Materials and methods: Cross-sectional study comprising of 60 patients which were divided into four groups according to their age. Each of the four groups consisted of 15 participants of whom 30 were males and 30 were females. All the patients meeting the inclusion and exclusion criteria were randomly selected and alginate impressions of the hard palate were taken and casted by dental stone. The data were assessed based on the Thomas and Kotze classification (1983) and the rugae patterns were delineated using sharp graphite pencil under adequate light and were analysed macroscopically.Statistical analysis: The obtained values were analysed using Student’s t- test for evaluation of gender difference in rugae patterns and ANOVA was applied for determination of age groups using SPSS version 20.0 software.Results: Palatal rugae of right side showed higher prevalence and curved rugae in females than in males and the finding is statistically significant. The mean number of rugae showed a slight decreasing trend with increasing age with more curved rugae and size of the palatal rugae is slightly increased up till the middle age group, as growth ceases thereafter.Conclusion: The present study reveals significant gender and age difference in palatal rugae pattern. Thus, palatal rugae appear to possess features of an ideal forensic identification parameters such as uniqueness, postmortem resistance and stability, provided antemortem record exists.
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O'Rourke, Katherine I., John V. Duncan, James R. Logan, Anne K. Anderson, Dianne K. Norden, Elizabeth S. Williams, Bret A. Combs, Robert H. Stobart, Gary E. Moss, and Diane L. Sutton. "Active Surveillance for Scrapie by Third Eyelid Biopsy and Genetic Susceptibility Testing of Flocks of Sheep in Wyoming." Clinical and Vaccine Immunology 9, no. 5 (September 2002): 966–71. http://dx.doi.org/10.1128/cdli.9.5.966-971.2002.
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ABSTRACT Control of scrapie, an ovine transmissible spongiform encephalopathy or prion disorder, has been hampered by the lack of conventional antemortem diagnostic tests. Currently, scrapie is diagnosed by postmortem examination of the brain and lymphoid tissues for PrPSc, the protein marker for this group of disorders. For live, asymptomatic sheep, diagnosis using tonsil or third-eyelid lymphoid tissue biopsy and PrPSc assay has been described. To evaluate the feasibility and efficacy of third-eyelid testing for identification of infected flocks and individual infected sheep, 690 sheep from 22 flocks were sampled by third-eyelid lymphoid tissue biopsy and immunohistochemistry. Sheep were further evaluated for relative genetic susceptibility and potential contact exposure to scrapie. Third-eyelid testing yielded suitable samples for 80% of the sheep tested, with a mean of 18.1 lymphoid follicles (germinal centers) per histologic section. Three hundred eleven of the sheep were sampled through passive surveillance programs, in which only sheep with potential contact with an infected sheep at a lambing event were tested, regardless of their scrapie susceptibility genotype. In addition, 141 genetically susceptible sheep with no record of contact with an infected animal at a lambing event were sampled through a targeted active surveillance program. Ten PrPSc-positive sheep were identified through the passive surveillance program, and an additional three PrPSc-positive sheep, including two from flocks with no history of scrapie, were identified through the active surveillance program. All PrPSc-positive sheep had the highly susceptible PrP genotype. Third-eyelid testing is a useful adjunct to flock monitoring programs, slaughter surveillance, and mandatory disease reporting in a comprehensive scrapie eradication and research program.
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Prabhakar, Manoj, Preethi Murali, and B. Sivapathasundharam. "Covid 19 – A Forensic Odontologist Perspective." Journal of Forensic Dental Sciences, February 28, 2022, 117–19. http://dx.doi.org/10.18311/jfds/12/2/2020.614.
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Investigations related to forensic odontology involves handling of antemortem as well as postmortem dental records. In case of any identification process, forensic odontologists may end up in exposing these dental related records. Exposure to any biological remains, and its related surfaces or objects at the scene, during this pandemic situation, puts any forensic professional at risk towards COVID-19. A detailed description on the risk involved during dental identification and autopsy procedures, and the knowledge about the precautionary measures which have to be exercised, makes the forensic team to carry forth the work cautiously without any perplexity or doubt.
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Sato, Mitsuru, Yohan Kondo, Masashi Okamoto, and Naoya Takahashi. "Development of individual identification method using thoracic vertebral features as biometric fingerprints." Scientific Reports 12, no. 1 (September 29, 2022). http://dx.doi.org/10.1038/s41598-022-20748-w.
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AbstractIdentification of individuals is performed when a corpse is found after a natural disaster, incident, or accident. DNA and dental records are frequently used as biometric fingerprints; however, identification may be difficult in some cases due to decomposition or damage to the corpse. The present study aimed to develop an individual identification method using thoracic vertebral features as a biological fingerprint. In this method, the shortest diameter in height, width, and depth of the thoracic vertebrae in the postmortem image and a control antemortem were recorded and a database was compiled using this information. The Euclidean distance or the modified Hausdorff distance was calculated as the distance between two points on the three-dimensional feature space of these measurement data. The thoracic vertebrae T1-12 were measured and the pair with the smallest distance was considered to be from the same person. The accuracy of this method for identifying individuals was evaluated by matching images of 82 cases from a total of 702 antemortem images and showed a hit ratio of 100%. Therefore, this method may be used to identify individuals with high accuracy.
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Chandler, Susan, Stephen M. Sudi, Keané C. Bailie, and Manogari Chetty. "The challenge of unidentified decedents in Africa: The need for training and research in forensic odontology to strengthen a multidisciplinary approach." Frontiers in Oral Health 3 (September 26, 2022). http://dx.doi.org/10.3389/froh.2022.1017736.
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IntroductionThe management of unidentified decedents suspected to be undocumented migrants is a growing humanitarian crisis in Africa. Identification of the dead and the right of the family to know the fate of a decedent is a fundamental human right. Forensic odontology methods can provide helpful and assisting information in the identification even in challenging low-resource settings. South Africa and other countries that are part of significant migration routes face the problem of unidentified decedents.DiscussionThe fundamental application of forensic odontology relies on the availability of good antemortem dental records. The state of dental records was reported to be suboptimal in South Africa and other African countries. Incorporating forensic odontology into the undergraduate training in the 23 dental schools in Africa will increase the understanding of the value of maintaining accurate dental records and potentially facilitate collaboration with dentists and forensic odontologists in cases where dental features can be used for identification. South Africa offers postgraduate training in forensic odontology, and prospects for research in Africa need to be explored.ConclusionThe development of a forensic odontology career path and research prospects will provide African countries with the potential for building multidisciplinary teams to assist in solving the challenge of unidentified decedents.
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Noorsaeed, Ashwag Siddik, Ali Hussain Almohammedsaleh, Mustafa Mohammed Alhayek, Abdullah Abdulhameed Alnajar, Osama Nasser Kariri, Abdullah Ibrahim Mohammed Albakri, A. Alhashmy Alamer, Mohammad Kamel, D. Alharbi, Thamer Abdullah, Alshaheen, Eyad Tariq, and M. Aljanubi, Mohammed Omar. "Overview on Updates on Digital Dental Radiography." Journal of Pharmaceutical Research International, December 17, 2021, 23–28. http://dx.doi.org/10.9734/jpri/2021/v33i59b34347.
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Wilhelm Roentgen first discovered X-rays in 1895. Since its introduction in the mid-1980s, digital radiography has surpassed traditional screen-film radiography. Since 2000, more than 75 percent of medical clinics in the United States have migrated to digital radiography (DR). In fact, the US government has ordered that all medical records be converted to digital. Indirect, direct, or semi-direct digital radiography pictures are types of digital radiography currently available. Forensic radiology is a branch of medical imaging technology that helps clinicians. Radiology technology has evolved and grown tremendously in recent years. When comparing aggregated antemortem and postmortem information, radiographs are crucial. Adopting new technologies into a dental business demands a certain amount of bravery. After all, why alter things if your practise is running smoothly? To grasp the new equipment and procedures, the dentist and his or her staff will need further training. It's not always apparent how the new strategy will influence the practice's present logistics. These factors may cause the practitioner to be hesitant to alter present techniques. In this article we’ll reviewing digital dental radiography, and what are the advantages of going digital. And also what are the challenges that face us.
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Chahal, C. Anwar A., David J. Tester, Ahmed U. Fayyaz, Keerthi Jaliparthy, Nadeem A. Khan, Dongmei Lu, Mariha Khan, et al. "Confirmation of Cause of Death Via Comprehensive Autopsy and Whole Exome Molecular Sequencing in People With Epilepsy and Sudden Unexpected Death." Journal of the American Heart Association 10, no. 23 (December 7, 2021). http://dx.doi.org/10.1161/jaha.121.021170.
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Background Sudden cardiac arrest is the leading mode of death in the United States. Epilepsy affects 1% of Americans; yet epidemiological data show a prevalence of 4% in cases of sudden cardiac arrest. Sudden unexpected death in epilepsy (SUDEP) may share features with sudden cardiac arrest. The objective of this study was to report autopsy and genomic findings in a large cohort of SUDEP cases. Methods and Results Mayo Clinic Sudden Death Registry containing cases (ages 0–90 years) of sudden unexpected and unexplained deaths 1960 to present was queried. Exome sequencing performed on decedent cases. From 13 687 cases of sudden death, 656 (4.8%) had a history of seizures, including 368 confirmed by electroencephalography, 96 classified as SUDEP, 58 as non‐SUDEP, and 214 as unknown (insufficient records). Mean age of death in SUDEP was 37 (±19.7) years; 56 (58.3%) were male; 65% of deaths occurred at night; 54% were found in bed; and 80.6% were prone. Autopsies were obtained in 83 cases; bystander coronary artery disease was frequently reported as cause of death; nonspecific fibrosis was seen in 32.6% of cases, in structurally normal hearts. There were 4 cases of Dravet syndrome with pathogenic variants in SCN1A gene. Using whole exome sequencing in 11 cases, 18 ultrarare nonsynonymous variants were identified in 6 cases including CACNB2, RYR2, CLNB, CACNA1H, and CLCN2 . Conclusions This study examined one of the largest single‐center US series of SUDEP cases. Several cases were reclassified as SUDEP, 15% had an ECG when alive, and 11 (11.4%) had blood for whole exome sequencing analysis. The most frequent antemortem genetic finding was pathogenic variants in SCN1A ; postmortem whole exome sequencing identified 18 ultrarare variants.
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Sebbag, Lionel, Sara M. Thomasy, Adriana Leland, Madison Mukai, Soohyun Kim, and David J. Maggs. "Altered Corneal Innervation and Ocular Surface Homeostasis in FHV-1-Exposed Cats: A Preliminary Study Suggesting Metaherpetic Disease." Frontiers in Veterinary Science 7 (January 26, 2021). http://dx.doi.org/10.3389/fvets.2020.580414.
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Metaherpetic disease is recognized in humans affected by herpes simplex virus-1 but is not reported in cats affected by feline herpesvirus-1 (FHV-1) despite the high prevalence of herpetic disease in this species and strong similarities in viral biology between alphaherpesviruses of humans and cats. This preliminary work evaluated cats naïve to FHV-1 (n = 9 cats, 18 eyes; control population) and cats naturally exposed to FHV-1 (n = 4 cats, 7 eyes), as confirmed by serologic testing and review of medical records. Antemortem assessment included clinical scoring, blink rate, corneal aesthesiometry, tear film breakup time (TFBUT), and Schirmer tear test-1 (STT-1) with or without the nasolacrimal reflex. Post-mortem assessment involved confocal microscopy of the corneas and evaluation of corneal nerves with ImageJ. Groups were compared with Student's t-tests and results are presented as mean ± standard deviation. Compared to control, herpetic cats had significantly higher (P ≤ 0.010) clinical scores (0.2 ± 0.4 vs. 4.6 ± 2.8) and response to nasolacrimal stimulation (7.8 ± 10.8% vs. 104.8 ± 151.1%), significantly lower (P < 0.001) corneal sensitivity (2.9 ± 0.6 cm vs. 1.4 ± 0.9 cm), STT-1 (20.8 ± 2.6 mm/min vs. 10.6 ± 6.0 mm/min), TFBUT (12.1 ± 2.0 s vs. 7.1 ± 2.9 s), and non-significantly lower blink rate (3.0 ± 1.5 blinks/min vs. 2.7 ± 0.5 blinks/min; P = 0.751). All parameters evaluated for corneal nerves (e.g., nerve fiber length, branching, occupancy) were notably but not significantly lower in herpetic vs. control cats (P ≥ 0.268). In sum, cats exposed to FHV-1 had signs suggestive of corneal hypoesthesia and quantitative/qualitative tear film deficiencies when compared to cats naïve to the virus. It is possible these are signs of metaherpetic disease as reported in other species.
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Ozawa, Sarah M., Jennifer E. Graham, David Sanchez-Migallon Guzman, Samuel M. Tucker, Olivia A. Petritz, Patrick Sullivan, James B. Robertson, and Michelle G. Hawkins. "Clinicopathological findings in and prognostic factors for domestic rabbits with liver lobe torsion: 82 cases (2010–2020)." Journal of the American Veterinary Medical Association, June 22, 2022, 1–9. http://dx.doi.org/10.2460/javma.22.03.0154.
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Abstract OBJECTIVE To document clinicopathologic findings in domestic rabbits with liver lobe torsion and identify prognostic factors. ANIMALS 82 rabbits. PROCEDURE Medical records of 4 institutions were reviewed to identify rabbits with an antemortem diagnosis of liver lobe torsion that were examined between 2010 and 2020. RESULTS The prevalence of liver lobe torsion was 0.7% (82/11,402). In all 82 rabbits, the diagnosis was made by means of abdominal ultrasonography. Fifty (60.1%) rabbits underwent liver lobectomy, 23 (28%) received medical treatment alone, and 9 (10.9%) were euthanized or died on presentation. Overall, 32 (39%) rabbits died within 7 days of initial presentation and 50 (61%) survived. Seven-day survival rate did not differ significantly between medical treatment alone and surgical treatment. However, median survival time following medical treatment (530 days) was shorter than that following surgical treatment (1,452 days). Six of 14 rabbits had evidence of systemic inflammatory disease on necropsy. Rabbits with right liver lobe torsion were less likely to survive for 7 days than were those with caudate torsions (P = 0.046; OR, 3.27; 95% CI, 1.04 to 11.3). Rabbits with moderate to severe anemia were less likely to survive for 7 days than were rabbits that were not anemic or had mild anemia (P = 0.006; OR, 4.41; 95% CI, 1.55 to 12.51). Other factors associated with a decreased 7-day survival rate were high heart rate at admission (P = 0.013) and additional days without defecation after admission (P < 0.001). Use of tramadol was associated with an increased survival rate (P = 0.018). CLINICAL RELEVANCE The prognosis for rabbits with liver lobe torsions was more guarded than previously described. Rabbits that underwent liver lobectomy had a longer median survival time than did rabbits that only received medical treatment.
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Story, Melinda R., Yvette S. Nout-Lomas, Tawfik A. Aboellail, Kurt T. Selberg, Myra F. Barrett, C. Wayne Mcllwraith, and Kevin K. Haussler. "Dangerous Behavior and Intractable Axial Skeletal Pain in Performance Horses: A Possible Role for Ganglioneuritis (14 Cases; 2014–2019)." Frontiers in Veterinary Science 8 (December 10, 2021). http://dx.doi.org/10.3389/fvets.2021.734218.
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Introduction: Dangerous behavior is considered an undesired trait, often attributed to poor training or bad-tempered horses. Unfortunately, horses with progressive signs of dangerous behavior are often euthanized due to concerns for rider safety and limitations in performance. However, this dangerous behavior may actually originate from chronic axial skeleton pain. This case series describes the medical histories and clinical presentations of horses presented for performance limitations and dangerous behavior judged to be related to intractable axial skeleton pain.Material and Methods: Fourteen horses that developed severe performance limitations resulting in euthanasia were included. A complete spinal examination and behavioral responses, gait and neurologic evaluations, diagnostic imaging, gross pathologic and histopathologic examinations of the axial skeleton were performed on all horses. A tentative diagnosis of the affected spinal region was formulated using medical records, owner and trainer complaints, and antemortem examination findings. The selected spinal regions were further examined with gross and histopathologic evaluations of the associated osseous, soft tissue and neural tissues.Results: Ten horses showed severe behavioral responses during the myofascial and mobilization examinations. Based on an aggregate evaluation, the cervicothoracic and lumbosacral regions were the most common regions believed to be the primary area of concern. All horses had moderate to severe ganglionitis present at multiple vertebral levels. Subdural and epidural hemorrhage or hematomas were a common finding (71%) in the cervicothoracic and lumbosacral regions.Discussion: In this case series, neuropathic (i.e., structural) pain was judged to be the underlying cause of dangerous behavior. The dorsal root ganglia (DRG) serve an important role in relaying peripheral sensory information to the central nervous system and ganglionitis has been associated with neuropathic pain syndromes. This series highlights the need for more in-depth understanding of pain behavior and its clinical presentation and progression in chronic or severely affected horses. Limitations of the study are the lack of age-matched control DRG and the incomplete collection of DRG from every vertebral level of interest.
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Khant, Kyaw, Mojtaba Mirzaei, Golsa Joodi, Brittany M. Bogle, Jessica P. Flowers, Samip M. Patel, Feng-Chang Lin, and Ross J. Simpson. "Abstract P028: High Framingham General Cardiovascular Disease Risk Scores in Victims of Out of Hospital Sudden Death." Circulation 137, suppl_1 (March 20, 2018). http://dx.doi.org/10.1161/circ.137.suppl_1.p028.
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Introduction: Individuals with a history of cardiovascular disease (CVD) have a high risk of out-of-hospital sudden unexpected death (OHSUD). However, most OHSUDs occur in victims without a prior history of CVD. Information on CVD risk in these victims is scarce. Hypothesis: We hypothesized that OHSUD victims who had no prior diagnosis of CVD have higher 10-year CVD risk compared to a matched living control population. Methods: OHSUD cases were adjudicated from all emergency medical service attended out-of-hospital deaths aged 30-64 in Wake County, NC between 2013-2015. Age group and gender-matched controls were randomly selected from Wake County residents who visited a local healthcare facility over the same period (~3:1 match ratio). We obtained two years of medical records prior to death (cases) or last visit (controls). After excluding individuals with a history of CVD, we calculated the 10-year risk of CVD for each subject using the published general CVD algorithms by D'Agostino et al. Risk was classified into low (<6%), moderate (6%-20%), and high (>20%). Results: Among subjects without CVD, we included 106 cases and 414 controls who had sufficient data for calculating Framingham risk score. Gender distribution was similar in both case and control groups. The average 10-year risk of CVD was higher for OHSUDs than controls (29% vs. 16%, p=<0.0001). Similar results were found in both men (34% vs. 19%, p=<0.0001) and women (11% vs. 7.3%, p=0.0005). A larger proportion of OHSUDs were considered “high risk” compared to controls (57% (60 of 106) vs. 28% (114 of 414), p=<0.001). This finding remained significant when stratified by gender (Figure). Conclusion: The majority of out of hospital sudden death victims without known CVD are at high risk of cardiovascular disease. This finding bolsters the essential role of office-based risk assessment tools in identifying high risk patients antemortem. Targeted interventions for intensive CVD risk reduction may lead to a decrease in sudden deaths.
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Dalgaard, C. V., B. L. Hansen, E. M. Jacobsen, A. Kjerrumgaard, J. Tfelt-Hansen, P. E. Weeke, B. G. Winkel, A. H. Christensen, and H. Bundgaard. "Diagnostic findings in relatives to victims of sudden unexplained death or non-autopsied possible sudden cardiac death." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.3632.
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Abstract Introduction Sudden cardiac death (SCD) may be caused by several inherited cardiac diseases and screening and treatment of relatives may be lifesaving. Sudden unexplained death (SUD) victims have been autopsied, whereas non-autopsied possible SCD (pSCD) victims are only filtered on manner of death and medical records. Screening of relatives may identify an inherited cardiac disease. Purpose To assess the diagnostic yield at initial evaluation and during follow-up of relatives to SUD and pSCD victims. Furthermore, to evaluate the outcome in the relatives. Methods We retrospectively included first-degree relatives to SUD and pSCD victims referred to our tertiary center from 2005 to 2018. Probands with known antemortem inherited cardiac disease were excluded. Data from systematic screening and routine follow-up of the relatives were registered. Results We included 371 first-degree relatives from 187 families: 276 SUD relatives (age at initial evaluation 35±17 years, 54% men;) and 95 pSCD relatives (age at initial evaluation 40±15 years, 51% men). The diagnostic yield among SUD families was 18%, among pSCD families 13% (p>0.05 between groups). The diagnoses in SUD families were mainly channelopathies (68%), whereas the pSCD families were diagnosed with cardiomyopathies, channelopathies, and premature ischemic heart disease (Figure 1). The vast majority of diagnosed families (93%) were diagnosed at the initial evaluation and only two families were diagnosed during the mean follow-up of 5.4 years. During follow-up, 57 (15%) relatives had a cardiac-related hospitalization, 12 (3%) relatives had a cardiac device implanted, three (1%) relatives died of non-cardiac causes, and one (0.5%) relative had a myocardial infarction. There was no significant difference in cardiac event rates between the SUD and pSCD groups (all p>0.05). Conclusion One in 6–7 families with SUD or pSCD victims obtained a diagnosis based on screening of relatives; we mainly diagnosed channelopathies in SUD families and a broader spectrum of inherited cardiac disease in the pSCD families. The majority of affected relatives was diagnosed at the initial evaluation and clinical follow-up may not be warranted in all relatives with normal findings at initial screening. Figure 1. Family diagnoses in categories, n (%) Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): The Capital Regions Research Foundation and The A.P. Moeller Foundation.
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Nuzzolese, E. "Electronic health record and blockchain architecture: forensic chain hypothesis for human identification." Egyptian Journal of Forensic Sciences 10, no. 1 (October 6, 2020). http://dx.doi.org/10.1186/s41935-020-00209-z.
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Abstract Background Forensic dental identification relies on the collection and comparison of antemortem and postmortem dental data and dental evidence. There are software solutions capable of archiving postmortem (PM) and antemortem (AM) data, with search and comparative tools which are user-centric and do not allow open search options and data mining of all dental related data, except through the use of coded data. This reduces interoperability and raises dental data incompatibility challenges. Blockchain technology could help introduce a trusted, secure, and holistic ecosystem in the electronic health record (EHR) system with a forensic interface accessed by experts in forensic pathology and forensic odontology for the purpose of identifying human remains and retrieve identifying data of compatible missing persons from the health and dental electronic record system, with the further advantage of protecting data breaches, redundancies, inconsistencies, and errors. Blockchain technology, and a forensic chain, can enhance forensic data management and human identification process by managing the missing person lists, create AM data repositories as shared data with the EHRs of living individuals, create PM data repositories of recovered from identifying autopsies unidentified persons, and support the preliminary comparison of compatible biological profiles during the final reconciliation phase. Conclusion In this hypothesis, author investigates possible applications of blockchain technology as a holistic technical and interoperability solution for managing both health/dental data for a medical as forensic human identification use.
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Dutta, Megha, Baishali Ghosh, Anannya Biswas, and Danie Kingsley. "Forensic odontology." International journal of health sciences, July 2, 2022, 6420–31. http://dx.doi.org/10.53730/ijhs.v6ns5.10130.
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The idea of using dental evidence in forensic investigations has aroused so much interest in the past that forensic odontology has even been suggested as one way to identify specific criminal cases. Forensic odontology plays an important role in situations where routine diagnostic procedures, such as finger printing and visual acuity, can be performed, in cases of decomposed, burnt or skeletal bodies. The lack of proper dental record and lack of the current practice of maintaining dental record, insufficient training in the field of dentistry for oral pathologist, lack of standard techniques, and lack of antemortem data are some serious problems faced in this field. This review articles deals with providing some solutions to the problems and assess the awareness regarding the dental record maintenance among dentists and create a national database for odontology.
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Aggarwal, Bindu, Rakesh K. Gorea, Abhinav Gorea, and Arshdeep Gorea. "Occipitalization and its clinical relevance: A case report." International Journal of Ethics, Trauma & Victimology, OF (December 18, 2016). http://dx.doi.org/10.18099/ijetv.v0iof.6851.
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Occipitalization of the atlas or atlanto-occipital fusion is one of the osseous anomalies of the craniovertebral junction. This fusion may be partial or complete and can be due to failure in segmentation and separation of the most caudal occipital sclerotome and the first cervical sclerotome.We present a case report of complete occipitalization of the atlas which was observed during undergraduate teaching at Luxmi Bai Dental College, Patiala. Such an anomaly is of interest to anatomists, physicians, radiologists and neurologists as it can cause a variety of neurological symptoms. Occipitalization can cause sudden death and an antemortem record of such an anomaly can help in identification of the deceased. Hence, occipitalization can be of interest to the forensic investigators in establishing the identity of the deceased.
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Aggarwal, Bindu, Rakesh K. Gorea, Abhinav Gorea, and Arshdeep Gorea. "Occipitalization and its clinical relevance: A case report." International Journal of Ethics, Trauma & Victimology 2, no. 02 (December 28, 2016). http://dx.doi.org/10.18099/ijetv.v2i02.6860.
Full textAbstract:
Occipitalization of the atlas or atlanto-occipital fusion is one of the osseous anomalies of the craniovertebral junction. This fusion may be partial or complete and can be due to failure in segmentation and separation of the most caudal occipital sclerotome and the first cervical sclerotome.We present a case report of complete occipitalization of the atlas which was observed during undergraduate teaching at Luxmi Bai Dental College, Patiala. Such an anomaly is of interest to anatomists, physicians, radiologists and neurologists as it can cause a variety of neurological symptoms. Occipitalization can cause sudden death and an antemortem record of such an anomaly can help in identification of the deceased. Hence, occipitalization can be of interest to the forensic investigators in establishing the identity of the deceased.
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Adebayo, Joyce, Victor Ojo, Gabriel Ogundipe, and Patrick Mboya Nguku. "Evaluation of Animal Rabies Surveillance System, Ekiti State, Nigeria, 2012-2017." Online Journal of Public Health Informatics 11, no. 1 (May 30, 2019). http://dx.doi.org/10.5210/ojphi.v11i1.9784.
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ObjectiveThe objectives of this study are to evaluate the current animal rabies surveillance system in the state and suggest recommendations.IntroductionRabies is a zoonotic, neglected viral disease. Every 10 minutes, the world loses a life, especially children, to dog-mediated rabies. Yet it is 100% preventable. Africa, including Nigeria, has major share of the disease. Eradication of human rabies relies majorly on control of rabies in animals and this cannot be achieved without good surveillance system of the disease in animal, especially dogs. There is little or no information as to whether the surveillance system in Nigeria is effective.MethodsWe reviewed the medical records of all rabies cases reported in the 10 government and 5 registered private veterinary health facilities in the 16 LGAs of the state. We extracted 44 cases of rabies in all, between review period of 2012-2017. We also interviewed 25 key stakeholders in the system using Key Informant Interview (KII) and questionnaires. We followed the steps stated in CDC guideline for evaluation of public health surveillance system to assess the key attributes and components of the system, and analysed the data using Microsoft Excel.ResultsTwo (20%) of the government and only one in five private veterinary health facilities had records on rabies cases. All reported cases of suspected rabies involved dog bites. The confirmatory status of 32 (72.7%) of the suspected cases were unknown. Six (37.5%) LGAs did not have access to any veterinary health facility. Average of 1 technical staff per veterinary facility was seen. Overall, the system was useful and flexible. It was fairly simple, acceptable and representative. Both sensitivity and predictive Value Positive (PVP) were less than 1% while the timeliness, data quality and stability were poorConclusionsThe surveillance system was performing below optimal level. There is need for improvement in the animal rabies surveillance system to achieve elimination of human rabies in Nigeria.ReferencesAdedeji, A. O., Okonko, I. O., Eyarefe, O. D., Adedeji, O. B., Babalola, E. T., and Ojezele, M. O. (2010). An overview of rabies - History , epidemiology , control and possible elimination. African Journal of Microbiology Research, 4(22), 2327–2338.Aliyu, T. (2010). Prevalence of Rabies Virus Antigens in Apparently Healthy Dogs in Yola , Nigeria. Researcher, 2(2), 1–14.Ameh, V. O., Dzikwi, A. A., and Umoh, J. U. (2014). Assessment of Knowledge , Attitude and Practice of Dog Owners to Canine Rabies in Wukari Metropolis , Taraba State Nigeria. Global Journal of Health Science, 6(5), 226–240.Burgos-Cáceres, S., and Sigfrido. (2011). Canine Rabies: A Looming Threat to Public Health. Animals, 1(4), 326–342.Dutta, J. K., and Dutta, T. K. (1994). Rabies in endemic countries. BMJ (Clinical Research Ed.), 308(6927), 488–9.Ehimiyein, A. M., and Ehimiyein, I. O. (2014). Rabies– Its Previous and Current Trend as an Endemic Disease of Humans and Mammals in Nigeria. Journal of Experimental Biology and Agricultural Science, 2(2320), 137–149.El-moamly, A. (2014). Immunochromatographic Techniques : Benefits for the Diagnosis of Parasitic Infections. Austin Chromatography, 1(4), 1–8.Fekadu, M. (1993). Canine rabies. Journal of Veterinary Research, 60, 421–427.Kasempimolporn, S., Saengseesom, W., Huadsakul, S., Boonchang, S., and Sitprija, V. (2011). Evaluation of a rapid immunochromatographic test strip for detection of Rabies virus in dog saliva samples. Journal of Veterinary Diagnostic Investigation, 23(6), 1197-1201.Muriuki J, Thaiyah A, Mbugua S, Kitaa J and Kirui. G. (2016). Knowledge,Attitude and Practices on Rabies and Socio-economic Value of Dog Keeping in isumu and Siaya countries, Kenya. International Jornal of Veterinary Science, 5(1), 29–33.National Population Commission. (2009). 2006 population and housing census of the Federal Republic of Nigeria. Official Gazette of the Federal Republic of Nigeria, 96(2), 1.Ogunkoya, A. ., Aina, O. ., Adebayo, O. ., Oluwagbenga, A. ., Tirmidhi, A. ., Audu, S. and Garba, A. (2012). Rabies Antigen Spread Amongst Apparently Healthy Dogs in Nigeria : A Review. Rita Brazil, 8(October), 74.OIE: World Organization for Animal Health. (2012). OIE Global Conference on Rabies Control: OIE - World Organisation for Animal Health. on-rabies-control/OIE: World Organization for Animal Health. (2014). Dog vaccination: the key to end dog-transmitted human rabies : OIE - World Organisation for Animal Health.Otolorin, G. R., Umoh, J. U., Dzikwi, A. A., and Anglais, A. E. (2014). Prevalence of Rabies Antigen in Brain Tissue of Dogs Slaughtered for Human Consumption and Evaluation of Vaccination of Dogs Against Rabies in Aba , Abia State Nigeria. World J Public Health Sciences, 3(1), 5–10.Panda, S., Mitra, J., Chowdhury, S., and Sarkar, S. N. (2016). Detection Of Rabies Viral Antigen In Cattle By Rapid Immunochromtographic Diagnostic Test. Explor Anim Medical Res, 6(1), 119–122.Sharma, P., Singh, C. K., and Narang, D. (2015). Comparison of immunochromatographic diagnostic test with heminested r everse transcriptase polymerase chain reaction for detection of rabies virus from brain samples of various species. Veterinary World, 8(2), 135–138.Singh, C K; Kaw, A; Bansal, K; Dandale, M and Pranoti, S. (2012). Approaches for antemortem diagnosis of rabies 1. CIBTech Journal of Biotechnology, 1(1), 1–16.Takayama, N. (2008). Rabies: A preventable but incurable disease. Journal of Infection and Chemotherapy, 14(1), 8–14.Wang, H., Feng, N., Yang, S., Wang, C., Wang, T., Gao, Y. and Xia, X. (2010). A rapid immunochromatographic test strip for detecting rabies virus antibody. Journal of Virological Methods, 170(1–2), 80–5.WHO. (2016). WHO | Rabies. WHO.Wu, X., Hu, R., Zhang, Y., Dong, G. and Rupprecht, C. E. (2009). Reemerging rabies and lack of systemic surveillance in People’s Republic of China. Emerging Infectious Diseases, 15(8), 1159–64.
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Tremblay, Kenneth, and Scott Burnett. "Test of Dental Ablation Scoring Criteria." Bioarchaeology International, January 25, 2023. http://dx.doi.org/10.5744/bi.2022.0020.
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Intentionally modified teeth provide a durable record of past identities, but their identification in archaeological samples has been inconsistent. This study assesses common diagnostic criteria for identifying intentional dental ablation by testing for false-positive cases of ablation in a control group of non-human primates where no true cases of dental ablation are expected. The primary author observed the dentition of 849 non-human primates from the National Museum of Natural History’s Division of Mammals, including great apes, lesser apes, and relatively large-bodied, Old-World monkeys. A smaller sample was selected for further study based on antemortem tooth absence and collection history. Seven different methodologies using combinations of six diagnostic criteria for the identification of dental ablation were chosen from a sample of published studies. To determine which criteria combinations may have falsely identified dental ablation in these specimens were, the non-human primate control group was analyzed based on anterior tooth loss, lack of disease, symmetry of loss, full healing of the alveolus, lack of evidence for trauma, and normal tooth spacing. All scoring methodologies produced false-positive results, many diverging significantly from expected results. Dental ablation was falsely identified in 2–17% of the non-human primate control group, with the highest false-positive rates when symmetry or normal spacing were not included as discriminating criteria. This work demonstrates the necessity for thorough and descriptive methodologies for replicability to be possible. It also highlights the importance of symmetry and tooth spacing as diagnostic criteria to avoid false positives. Dientes con modificaciones intencionales dan un registro duradero de identidades pasadas, pero su identificación en especímenes arqueológicos ha sido inconsistente. Esta investigación evalúa los criterios de diagnóstico comunes para identificar la ablación dental intencional por medio de la prueba de casos de falsos positivos de ablación en un grupo de control de primates no humanos, donde no se esperan casos verdaderos de ablación dental. El autor principal observó la dentición de 849 primates no humanos de la División de Mamíferos del Museo Nacional de Historia Natural, incluso los grandes simios, los simios menores y los monos del Viejo Mundo de cuerpo relativamente grande. Se seleccionó una muestra para un análisis más profundo basado en la ausencia de dientes antemortem y la historia del espécimen. De una muestra de once investigaciones publicada, se eligieron siete metodologías diferentes que utilizan combinaciones de seis criterios de diagnóstico para la identificación de la ablación dental. Para determinar qué combinaciones de criterios pueden haber identificado falsamente la ablación dental en estos especímenes si fueran humanos, se analizó el grupo de control de primates no humanos en función de la pérdida de dientes anteriores, la falta de enfermedad, la simetría de la ausencia de dientes, la curación completa del hueso alveolar, la falta de evidencia para traumatismos y el espacio normal entre los dientes. Todos los métodos de análisis produjeron resultados falsos positivos, muchos de los Dientes con modificaciones intencionales dan un registro duradero de identidades pasadas, pero su identificación en especímenes arqueológicos ha sido inconsistente. Esta investigación evalúa los criterios de diagnóstico comunes para identificar la ablación dental intencional por medio de la prueba de casos de falsos positivos de ablación en un grupo de control de primates no humanos, donde no se esperan casos verdaderos de ablación dental. El autor principal observó la dentición de 849 primates no humanos de la División de Mamíferos del Museo Nacional de Historia Natural, incluso los grandes simios, los simios menores y los monos del Viejo Mundo de cuerpo relativamente grande. Se seleccionó una muestra para un análisis más profundo basado en la ausencia de dientes antemortem y la historia del espécimen. De una muestra de once investigaciones publicada, se eligieron siete metodologías diferentes que utilizan combinaciones de seis criterios de diagnóstico para la identificación de la ablación dental. Para determinar qué combinaciones de criterios pueden haber identificado falsamente la ablación dental en estos especímenes si fueran humanos, se analizó el grupo de control de primates no humanos en función de la pérdida de dientes anteriores, la falta de enfermedad, la simetría de la ausencia de dientes, la curación completa del hueso alveolar, la falta de evidencia para traumatismos y el espacio normal entre los dientes. Todos los métodos de análisis produjeron resultados falsos positivos, muchos de los 2–17% del grupo de control de primates no humanos, con las tasas más altas de falsos positivos cuando la simetría o el espacio normal no se incluyeron como criterios de discriminación. Este trabajo demuestra la necesidad de metodologías exhaustivas y descriptivas para la replicabilidad. También ilumina la importancia de la simetría y el espacio entre dientes como criterios diagnósticos para evitar falsos positivos.