Journal articles: 'ANP'

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Daniels, Lowri. "ANP News: ANP annual conference." Nurse Prescribing 9, no. 10 (October 2011): 480. http://dx.doi.org/10.12968/npre.2011.9.10.480.

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Daniels, Lowri. "ANP News: ANP annual conference." Nurse Prescribing 9, no. 8 (August 2011): 375. http://dx.doi.org/10.12968/npre.2011.9.8.375.

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Mu, Enrique. "The AHP/ANP Conference Community." International Journal of the Analytic Hierarchy Process 11, no. 3 (December 16, 2019): 300. http://dx.doi.org/10.13033/ijahp.v11i3.730.

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As IJAHP editor-in-chief, I have the unique opportunity of getting to know AHP/ANP scholars and practitioners from all over the world. While my initial acquaintance is usually through this journal, it is often followed by personal interactions in diverse academic meetings in our discipline.

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Weidemann, K., A. Montkowski, M. Kellner, and K. Jahn. "Evaluation of the anxiolytic profile of atrial natriuretic peptides (ANP) via ANP-A, ANP-B or ANP-C receptors." Emerging Therapeutic Targets 2, no. 1 (July 1998): 57–59. http://dx.doi.org/10.1517/14728222.2.1.57.

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Xu, Jicang, Linlin Li, and Ming Ren. "A Hybrid ANP Method for Evaluation of Government Data Sustainability." Sustainability 14, no. 2 (January 13, 2022): 884. http://dx.doi.org/10.3390/su14020884.

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The evaluation of government data sustainability is a multicriteria decision making problem. The analytic network process (ANP) is among the most popular methods in determining the weights of criteria, and its limitation is the un-convergence problem. This paper proposes a hybrid ANP (H-ANP) method, which aims to improve the ANP by combining the weights obtained from the analytic hierarchy process (AHP). The proposed method is proved to be convergent since the network of the H-ANP is strongly connected. According to the simulation experiments, H-ANP is more robust than ANP under different settings of parameters. It also shows a higher Kendall cor-relationship and lower MSE with respect to AHP, compared with the existing method (e.g., the averagely connected ANP method). An empirical example is also provided, which uses H-ANP to evaluate the government data sustainability of a city.

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Deliva, Robin Donna, and Uwe Ackermann. "Atrial natriuretic peptide and mechanisms of cardiovascular control. Role of serotonergic receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 3 (March 1, 1998): R711—R717. http://dx.doi.org/10.1152/ajpregu.1998.274.3.r711.

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Atrial natriuretic peptide (ANP) inhibits renal sympathetic nerve activity (RSNA), provided the vagi are intact. Afferents from chemosensitive cardiopulmonary receptors are specifically required. Such receptors produce the Bezold-Jarisch reflex, are prominent on the ventricular epicardium, and are richly supplied with 5-hydroxytryptamine type 3 (5-HT3) receptors. We tested the hypothesis that epicardial 5-HT3-sensitive neurons mediate depressor effects of ANP. Through a special catheter, anesthetized, sinoaortically denervated rats received pericardial test injections of ANP (28-amino acid rat ANP; 100 and 1,000 ng) in the presence or absence of 5-HT3 antagonist (Ondansetron, 20 μg/kg; n = 9). In other groups we observed the effects of systemic ANP while blocking either epicardial or systemic 5-HT3 receptors. Arterial blood pressure (ABP), heart rate, and RSNA were recorded continuously. Intravenous ANP (100 or 200 ng) decreased ABP and RSNA significantly. In contrast, intrapericardial ANP (100 or 1,000 ng) caused no significant fall in ABP or RSNA. Both intravenous and pericardial Ondansetron reduced the effects of intravenous ANP significantly, but the intravenous antagonism was significantly greater. We conclude that epicardial chemosensitive afferents are not sensitive to ANP and that sympathoinhibitory effects of ANP arise from a 5-HT3 agonist that cannot be produced when ANP is confined to the pericardial space.

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Huston, Jared, Jason Fritz, and Robert Gersch. "Cholinergic regulation of atrial natriuretic peptide in spleen during sepsis (110.4)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 110.4. http://dx.doi.org/10.4049/jimmunol.186.supp.110.4.

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Abstract Introduction: Cardiac atrial natriuretic peptide (ANP) regulates blood volume and pressure. ANP is also produced in spleen and reduces pro-inflammatory cytokine production in macrophages. The cholinergic anti-inflammatory pathway targets spleen to inhibit pro-inflammatory cytokines and organ damage in sepsis. We hypothesized that cholinergic regulation of systemic inflammation requires modulation of splenic ANP. Methods: Male 8-12 wk old BALB/c mice received LPS (15 mg/kg, i.p.), and were euthanized after 60 m. Nicotine (2 mg/kg, i.p.) or vehicle was given 1-2 h before LPS. TNF and ANP were measured using ELISA. Other mice received cecal ligation and puncture +/-splenectomy, and were euthanized at 24 h. One-way ANOVA or the Student’s t test was used to compare experimental groups. P-values < 0.05 are significant. Results: Nicotine significantly reduces systemic and splenic TNF. Nicotine significantly reduces systemic ANP and significantly increases splenic ANP. Nicotine fails to regulate TNF or ANP after splenectomy. Splenectomy significantly reduces systemic TNF and ANP (p < 0.07). Splenectomy significantly improves survival and decreases ANP after CLP. Conclusions: Cholinergic stimulation requires spleen to modulate systemic pro-inflammatory cytokines and ANP. Cholinergic stimulation increases splenic ANP and decreases systemic ANP. The cholinergic anti-inflammatory pathway may regulate systemic inflammation by limiting ANP release and enhancing splenic ANP signaling.

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Daniels, Lowri. "ANP News." Nurse Prescribing 9, no. 12 (December 2011): 596. http://dx.doi.org/10.12968/npre.2011.9.12.596.

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Daniels, Lowri. "ANP News." Nurse Prescribing 9, no. 6 (June 2011): 271. http://dx.doi.org/10.12968/npre.2011.9.6.271.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 10 (October 2012): 514. http://dx.doi.org/10.12968/npre.2012.10.10.514.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 12 (December 2012): 621. http://dx.doi.org/10.12968/npre.2012.10.12.621.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 2 (February 2012): 64. http://dx.doi.org/10.12968/npre.2012.10.2.64.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 4 (April 2012): 166. http://dx.doi.org/10.12968/npre.2012.10.4.166.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 6 (June 2012): 273. http://dx.doi.org/10.12968/npre.2012.10.6.273.

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Daniels, Lowri. "ANP News." Nurse Prescribing 10, no. 8 (August 2012): 376. http://dx.doi.org/10.12968/npre.2012.10.8.376.

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Daniels, Lowri. "ANP News." Nurse Prescribing 11, no. 2 (February 2013): 99. http://dx.doi.org/10.12968/npre.2013.11.2.99.

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Daniels, Lowri. "ANP News." Nurse Prescribing 11, no. 4 (April 2013): 205. http://dx.doi.org/10.12968/npre.2013.11.4.205.

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Daniels, Lowri. "ANP News." Nurse Prescribing 11, no. 6 (June 2013): 274. http://dx.doi.org/10.12968/npre.2013.11.6.274.

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Huda, Nurul, Desti Anggraini, Khalifah Muhamad Ali, Nova Rini, and Yosi Mardoni. "KOMPARASI AHP DAN ANP PENENTUAN SOLUSI PENGELOLAAN ZAKAT (KASUS DKI DAN SULSEL)." EKUITAS (Jurnal Ekonomi dan Keuangan) 17, no. 3 (September 24, 2018): 357–75. http://dx.doi.org/10.24034/j25485024.y2013.v17.i3.345.

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Artikel ini bertujuan untuk memetakan prioritas masalah dan solusi dalam pengelolaan zakat dengan membandingkan metode AHP dan ANP. Hasil penelitian memperlihatkan tiga macam prioritas masalah dan solusi pengelolaan zakat yang dibagi berdasarkan stakeholder zakat yaitu regulator, organisasi pengelola zakat (OPZ), serta muzaki dan mustahik zakat. Berdasarkan Metode AHP prioritas masalah pada OPZ sedangkan ANP adalah regulator. Prioritas masalah regulator adalah zakat belum menjadi obligatory system. Prioritas masalah OPZ yaitu rendahnya sinergi antara stakeholder zakat. Prioritas masalah mustahik/muzaki yaitu rendahnya pengetahuan muzaki. Baik metode AHP maupun ANP menghasilkan skor prioritas pemecahan masalah yang sama, yaitu OPZ. Prioritas solusi regulator adalah standarisasi dan akreditasi OPZ. Prioritas solusi OPZ menurut metode AHP dan ANP adalah peningkatan transparansi dan akuntabilitas. Metode AHP dan ANP mengalami perbedaan dalam penentuan prioritas solusi muzaki/mustahik, dimana AHP mengang- gap bahwa prioritas solusi muzaki/mustahik adalah meningkatkan kemudahan layanan, sementara pada metode ANP adalah peningkatan sosialisasi dan edukasi zakat. Meskipun menggunakan dua metode yang berbeda, ternyata hasil prioritas antara AHP dan ANP memiliki banyak kesamaan hasil (priorities). Hal ini kemungkinan dipengaruhi oleh adanya kemiripan jaringan model dalam hubungan (connections) antar simpul (node) yang telah terbentuk di dalam software superdecisions.

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Milkova, Maria, Olga Andreichikova, and Alexander Andreichikov. "AT THE JUNCTION OF MATHEMATICS AND PSYCHOLOGY: COGNITIVE ORIENTATION OF THE AHP/ANP AND NEW PERSPECTIVES OF STRUCTURING COMPLEXITY." International Journal of the Analytic Hierarchy Process 11, no. 1 (March 31, 2019): 110–26. http://dx.doi.org/10.13033/ijahp.v11i1.611.

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This paper aims to draw attention to the interdisciplinary research of the AHP/ANP methodology by emphasizing how it can be studied from a cognitive perspective. We provide an overview of the main cognitive approaches in decision-making, and consider different heuristics that lie at the basis of pairwise comparisons. We emphasize that the AHP/ANP must be considered at the junction of mathematics and psychology, and for further development of the methodology, we should examine the AHP/ANP from the cognitive point of view. We review the recent experimental studies of the AHP/ANP that test human behavior in real decision problems. We also discuss the future applicability of the AHP/ANP methodology in the Experience Age - the age of not only digital information and knowledge, but also behavior. This article is just a small step on the way to discovering the cognitive aspects and future extensions of decision making with the AHP/ANP.

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Huda, Nurul, Desti Anggraini, Khalifah Muhamad Ali, Nova Rini, and Yosi Mardoni. "KOMPARASI AHP DAN ANP PENENTUAN SOLUSI PENGELOLAAN ZAKAT (KASUS DKI DAN SULSEL)." EKUITAS (Jurnal Ekonomi dan Keuangan) 17, no. 3 (February 7, 2017): 357. http://dx.doi.org/10.24034/j25485024.y2013.v17.i3.2257.

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This article aims to map the priority problems and solutions in the management of zakat by comparing methods of AHP and ANP. The results showed three kinds of priority issues and solutions zakat management are shared by stakeholder’s charity regulators, zakat organization (OPZ), as well as muzakis and mustahik charity. Based on the method of AHP priority issue on OPZ while the ANP is the regulator. Priority issues regulators are not yet become obligatory zakat system. OPZ is a low priority issue synergies between stakeholders charity. Priority issues mustahik /muzakis ie lack of knowledge muzakis. Both AHP and ANP generate priority scores solving the same problem, namely OPZ. Priority regulator solution are standardization and accreditation OPZ. Priority OPZ solution according to the method of AHP and ANP are increased transparency and accountability. AHP and ANP to experience the difference in the prioritization of solutions muzakis/mustahik , which assume that the priority solution AHP muzakis/mustahik is to improve the ease of service, while the ANP method is to increase socialization and education charity. Although using two different methods, the result of priority between AHP and ANP has many similarities results (priorities). It is likely influenced by the similarity in network models of relationships (connections) between nodes that have formed in the software superdecisions.

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Ackermann, Uwe, and Newsha Azizi. "Increased central AT1-receptor activation, not systemic vasopressin, sustains hypertension in ANP knockout mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 278, no. 6 (June 1, 2000): R1441—R1445. http://dx.doi.org/10.1152/ajpregu.2000.278.6.r1441.

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We tested the hypothesis that hypertension in atrial natriuretic peptide (ANP) knockout mice is caused in part by disinhibition of angiotensin II-mediated vasopressin release. Inactin-anesthetized F2 homozygous ANP gene-disrupted mice (−/−) and wild-type (+/+) littermates were surgically prepared for carotid arterial blood pressure measurement (ABP) and background intravenous injection of physiological saline or vasopressin V1-receptor antagonist (Manning compound, 10 ng/g body wt) and subsequent intracerebroventricular (left lateral ventricle) injection of saline (5 μl) or ANP (0.5 μg) or angiotensin II AT1-receptor antagonist losartan (10 μg). Only (−/−) showed significant decrease in ABP after intracerebroventricular ANP or losartan. Both showed significant hypotension after intravenous V1 antagonist, but there was no difference between their responses. We conclude that 1) vasopressin contributes equally to ABP maintenance in ANP-disrupted mice and wild-type controls; 2) permanently elevated ABP in ANP knockouts is associated with increased central nervous angiotensin II AT1-receptor activation; 3) disinhibition of central nervous angiotensin II AT1receptors in ANP-deficient animals does not lead to a significant increase in the importance of vasopressin as a mechanism for blood pressure maintenance.

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Momoh, J. A., and Jizhong Zhu. "Optimal generation scheduling based on AHP/ANP." IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics) 33, no. 3 (June 2003): 531–35. http://dx.doi.org/10.1109/tsmcb.2003.811122.

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Ackermann, Uwe, and Robin Donna Deliva. "Reduced baroreceptor sensitivity during hypotension in ANP-knockout mice." Canadian Journal of Physiology and Pharmacology 79, no. 3 (March 1, 2001): 201–5. http://dx.doi.org/10.1139/y00-121.

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We studied baroreflex gain in inactin-anesthetized mice that had been genetically modified to be depleted of atrial natriuretic peptide (ANP -/-). Wild-type mice (ANP +/+) served as controls. ANP -/- mice had a significantly higher basal arterial blood pressure (ABP) than ANP +/+ mice [112 ± 7 vs. 80 ± 5 mmHg (mean ± SEM)]. Their basal heart rates were not different (491 ± 13 vs. 446 ± 19 bpm). A third group, composed of ANP +/+ mice only, was rendered acutely hypertensive by an intravenous infusion of arginine vasopressin acetate (0.3 pg bolus followed by 0.3 pg/h) so as to serve as a control for the elevated ABP in the ANP -/- mice. Transient changes in ABP were caused by bolus injections of oxymetazoline hydrochloride (1.5-3 ng) or sodium nitroprusside (20-100 ng). Baroreflex gain was calculated as the ratio of the peak heart rate change that followed the peak change in mean ABP resulting from injection of oxymetazoline or nitroprusside. There were no significant differences among the groups in their responses to transient hypertension. On the other hand, the ANP -/- mice showed a significantly depressed tachycardic response to transient hypotension when compared with the other two groups. We conclude that the ANP -/- mice are unable to increase efferent sympathetic nervous activity adequately above the high basal activity that is a feature of this animal model.Key words: atrial natriuretic peptides, knockouts, arterial blood pressure.

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You, Hui, and Suzanne G. Laychock. "Long-term treatment with atrial natriuretic peptide inhibits ATP production and insulin secretion in rat pancreatic islets." American Journal of Physiology-Endocrinology and Metabolism 300, no. 3 (March 2011): E435—E444. http://dx.doi.org/10.1152/ajpendo.00398.2010.

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Atrial natriuretic peptide (ANP) levels correlate with hyperglycemia in diabetes mellitus, but ANP effects on pancreatic islet β-cell insulin secretion are controversial. ANP was investigated for short- and long-term effects on insulin secretion and mechanisms regulating secretion in isolated rat pancreatic islets. A 3-h incubation with ANP did not affect basal or glucose-stimulated islet insulin secretion. However, 7-day culture of islets with 5.5 mM glucose and ANP (1 nM - 1 μM) markedly inhibited subsequent glucose (11 mM)-stimulated insulin secretion; total islet insulin content was not affected. Following ANP removal for 24 h, the islet insulin-secretory response to glucose was restored. The insulin-secretory response to other insulin secretagogues, including α-ketoisocaproic acid, forskolin, potassium chloride, and ionomycin were also markedly inhibited by chronic exposure to ANP. However, the combination of potassium chloride and α-ketoisocaproic acid was sufficient to overcome the inhibitory effects of ANP on insulin secretion. The glucose-stimulated increases in islet ATP levels and the ATP/ADP ratio were completely inhibited in ANP 7-day-treated islets vs. control; removal of ANP for 24 h partially restored the glucose response. ANP did not affect islet glycolysis. ANP significantly increased levels of islet activated hormone-sensitive lipase and the expression of uncoupling protein-2 and peroxisome proliferator-activated receptor-δ and -α. Although islet ANP-binding natriuretic peptide receptor-A levels were reduced to 60% of control after 7-day culture with ANP, the ANP-stimulated cGMP levels remained similar to control islet levels. Thus, long-term exposure to ANP inhibits glucose-stimulated insulin secretion and ATP generation in isolated islets.

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Peters, J. W. B., M. C. A. van Dommelen, and R. Bakker. "M ANP-opleidingen." De Verpleegkundig Specialist 11, no. 3 (September 2016): 17–19. http://dx.doi.org/10.1007/s40884-016-0034-8.

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Roos, Martin. "ANP verhindert Metastasen." Im Focus Onkologie 18, no. 5 (May 2015): 8. http://dx.doi.org/10.1007/s15015-015-1765-6.

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Tan, A. C. I. T. L., T. T. van Loenhout, E. J. P. Lanfers, P. W. C. Kloppenborg, and Th J. Benraad. "ANP in AMI." American Heart Journal 117, no. 6 (June 1989): 1406–7. http://dx.doi.org/10.1016/0002-8703(89)90449-3.

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Tan, Adriaan C. I. T. L., Tom T. van Loenhout, Evert J. P. Lamfers, Leon H. R. Bouwels, Peter W. C. Kloppenborg, and Theo J. Benraad. "ANP after AMI." American Heart Journal 120, no. 6 (December 1990): 1484–85. http://dx.doi.org/10.1016/0002-8703(90)90281-2.

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Kirytopoulos, Konstantinos A., Dimitra Voulgaridou, and Elena Rokou. "ANP SOLVER: an alternative tool for implementing the ANP method." International Journal of Applied Decision Sciences 4, no. 1 (2011): 34. http://dx.doi.org/10.1504/ijads.2011.038090.

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Janeš, Aleksander, and Nina Begičević Ređep. "Differences in prioritization of the BSC’s strategic goals using AHP and ANP methods." Journal of information and organizational sciences 42, no. 2 (December 10, 2018): 193–217. http://dx.doi.org/10.31341/jios.42.2.3.

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The development and empirical verification of the balanced scorecard (BSC) model, using the multi-criteria decision-making methods (MCDM) called the analytic hierarchy process (AHP) and the analytic network process (ANP), are the key issues of the presented research. The paper presents the methodology of the prioritization of the BSC goals with the AHP and ANP methods. Even though the prioritization of the goals is possible with both, findings from the empirical analysis showed that the ANP is more complementary with the BSC because of the influences among the goals in the BSC. The ANP supports the modelling of those influences (through dependencies) and the AHP does not. The paper discusses special situations in prioritizing the BSC goals (understanding the ANP from the perspective of the user and the BSC with strategic goals that do not directly influence any other strategic goal) and proposes solutions. Therefore, it can be asserted that introducing the ANP to implement the BSC and vice versa, improved the decision-making approach and the quality of the obtained results. The research was based on a case study of modelling the BSC for Ydria Motors LL (YM), a manufacturing company.

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Huang, Jih-Jeng, and Masahiro Inuiguchi. "Diminishing Utility Decision Model for Weighting Criteria." International Journal of Information Technology & Decision Making 14, no. 06 (November 2015): 1263–84. http://dx.doi.org/10.1142/s0219622015500303.

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The analytic hierarchy/network process (analytic hierarchy process (AHP)/analytic network process (ANP)) became the most popular tool for weighting criteria in the field of multiple criteria analysis during the 1980s. However, these models often suffer from criticisms because of their theoretical and practical problems. In this paper, the diminishing utility decision model (DUDM) is proposed in order to retain the pros and avoid the cons of the AHP and ANP for weighting criteria. The DUDM integrates the AHP and the concept of diminishing marginal utility in order to model the main and interaction weights of criteria, respectively. From the results of the numerical examples, it can be seen that the proposed method can solve two major limitations of the ANP. First, the proposed method can significantly reduce the number of questions that are asked in the ANP. Second, the proposed method can ensure convergence in many situations and avoid the problem of the ANP with regard to the absorbing state.

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Setiawan, Arbi Juniar. "Rekayasa Perangkat Lunak Aplikasi Keputusan Multi Kriteria dengan Algoritma Analytic Network Process (ANP) Berbasis Android." Jurnal Sistem Informasi 14, no. 1 (April 30, 2018): 35–42. http://dx.doi.org/10.21609/jsi.v14i1.571.

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Pengambilan keputusan multi kriteria merupakan salah satu teknik dalam menentukan sebuah pilihan dari beberapa alternatif pilihan. Ada beberapa metode dalam mengambil keputusan, salah satunya yaitu ANP (Analytic Network Process). ANP merupakan pengembangan dari metode AHP (Analytic Hierarchy Process). AHP merupakan sebuah metode yang berbentuk hirarki dimana setiap kriteria yang ada akan dibandingkan terlebih dahulu yang akan menghasilkan sebuah matriks biasa. Sedangkan ANP merupakan sebuah metode jaringan yang membandingkan semua hal termasuk kriteria dan alternatif yang ada sehingga mendapatkan suatu super matriks yang sangat kompleks. Saat ini metode ANP tidak hanya dihitung tetapi sudah ada aplikasi penunjang salah satunya yaitu Super Decisions. Aplikasi tersebut bisa digunakan untuk menghasilkan suatu keputusan dengan metode ANP. Setiap aplikasi pasti memiliki kelebihan maupun kekurangan. Untuk itulah diperlukan adanya pengembangan aplikasi yang sudah ada sebelumnya agar muncul aplikasi baru yang lebih baik.

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Petrov, V., and P. Lijnen. "Regulation of human erythrocyte Na+/H+ exchange by soluble and particulate guanylate cyclase." American Journal of Physiology-Cell Physiology 271, no. 5 (November 1, 1996): C1556—C1564. http://dx.doi.org/10.1152/ajpcell.1996.271.5.c1556.

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Guanylate cyclase activity in human erythrocytes is investigated by evaluating the intracellular guanosine 3',5'-cyclic monophosphate (cGMP) content in the presence of various agents that exert specific effects on soluble or particulate guanylate cyclase. The increase in the intraerythrocyte cGMP content by the soluble guanylate cyclase activators nitroprusside and NaNO2 suggests the presence of this enzyme in human erythrocytes. The effects of four different atrial natriuretic peptide (ANP) fragments on the intraerythrocyte cGMP content is also studied. ANP II and ANP III increase the intraerythrocyte cGMP content, whereas ANP I and des-Ser5,des-Ser6-ANP III are ineffective. Thus our data show that human erythrocytes possess particulate guanylate cyclase together with the soluble enzyme. The ANP fragments ANP II and ANP III also activate the erythrocyte Na+/H+ exchange. Nitroprusside, M & B 22948 (an inhibitor of cGMP phosphodiesterase), and the cGMP analogues dibutyryl cGMP and 8-bromoguanosine 3',5'-cyclic monophosphate also increase the erythrocyte Na+/H+ exchange rate. The latter data also suggest that the erythrocyte Na+/H+ exchange is regulated by cGMP.

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Feinberg, Bruce, Skyler Hime, Jeff Wojtynek, Igoni Dokubo, Ajeet Gajra, Yolaine Smith, and Jonathan Kish. "Physician treatment of metastatic triple-negative breast cancer in the immuno-oncology era: a discrete choice experiment." Future Oncology 16, no. 33 (November 2020): 2713–22. http://dx.doi.org/10.2217/fon-2020-0729.

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Aim: Guidelines list atezolizumab with nab-paclitaxel (ANP) as the preferred first-line (1L) therapy for metastatic triple-negative breast cancer (mTNBC) with PD-L1 expression ≥1%, but which clinical attributes impact ANP prescribing? Materials & methods: Medical oncologists participated in a discrete choice experiment (DCE) with four hypothetical mTNBC clinical scenarios to assess influences of: PD-L1 expression, menopausal status, prior adjuvant therapy and bulky liver metastases. Results: A total of 47% chose ANP in 1L irrespective of menopausal status, prior adjuvant therapy or tumor bulk. PD-L1 expression was the only attribute with a significant impact on ANP preference, with 69% choosing ANP for those with ≥1% expression versus only 26% for those with <1% (p < 0.00001). Conclusion: ANP choice for 1L mTNBC deviated from guidelines.

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Burgess, W. J., M. N. Perrott, and R. J. Balment. "Lack of effect of atrial natriuretic peptide and urodilatin on vasopressin-stimulated cyclic AMP production in microdissected rat inner medullary collecting ducts." Journal of Molecular Endocrinology 12, no. 2 (April 1994): 149–54. http://dx.doi.org/10.1677/jme.0.0120149.

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ABSTRACT It is unclear whether the diuretic effects of atrial natriuretic peptide (ANP) result, in part, from an inhibition of the renal actions of vasopressin. Moreover, accruing evidence suggests that the kidneys themselves may produce an ANP-like peptide, urodilatin, which shares many of the renal actions of ANP. The mechanism underlying the diuretic action of urodilatin has not yet been examined. Accordingly, we have investigated the potential modulatory actions of both ANP and urodilatin on vasopressin-stimulated cyclic AMP (cAMP) production in microdissected inner medullary collecting duct (IMCD) segments of rat kidney. ANP and urodilatin alone (at 10−8 or 10−6 m) had no demonstrable effect on cAMP accumulation in IMCD segments. Moreover, neither ANP nor urodilatin (each at 10−6 m) significantly altered either the profile or the absolute magnitude of the cAMP response stimulated by vasopressin. These findings indicate that neither ANP nor urodilatin interacts with the vasopressin-sensitive adenylate cyclase site in the rat IMCD to contribute to its diuretic actions.

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Ley, Arley, and Angelina Lina. "Designing Software Application Decision With Multi Criteria Android-based Analytic Network Process Algorithm." IAIC Transactions on Sustainable Digital Innovation (ITSDI) 2, no. 1 (October 23, 2020): 23–31. http://dx.doi.org/10.34306/itsdi.v2i1.349.

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Multi-criteria decision-making is one of the techniques in determining a choice of several alternative options. There are several methods in making decisions, one of which is ANP (Analytic Network Process). ANP is a development of AHP (Analytic Hierarchy Process) method. AHP is a hierarchical method in which any existing criteria will be compared first which will produce an ordinary matrix. While ANP is a network method that compares all things including criteria and alternatives that exist so as to obtain a super matrix is very complex. Currently ANP method is not only calculated but already there is software support one of them is Super Decisions. The software can be used to generate a decision by the ANP method. Every software must have advantages and disadvantages. That's why there is a need for software development that has been there before to appear new software better.

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Tan, Rui, You Mee Ahn, Hye Yoom Kim, Yun Jung Lee, Kyung Woo Cho, Dae Gill Kang, and Ho Sub Lee. "Atrial secretion of ANP is suppressed in renovascular hypertension: shifting of ANP secretion from atria to the left ventricle." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 3 (September 1, 2018): H590—H601. http://dx.doi.org/10.1152/ajpheart.00612.2017.

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In the present study, the change in secretion of atrial natriuretic peptide (ANP) from the atria was defined in hypertension accompanied by ventricular hypertrophy and increased synthesis of ANP. To identify the change of the secretion and mechanisms involved, experiments were performed in isolated perfused beating atria from sham-operated normotensive and renovascular hypertensive rats. Expression of ANP, natriuretic peptide receptor (NPR)-C, components of the renin-angiotensin system, and muscarinic signaling pathway was measured in cardiac tissues. Basal levels of ANP secretion and acetylcholine (ACh)- and stretch-induced activation of ANP secretion were suppressed in the atria from hypertensive compared with normotensive rats. ACh increased ANP secretion via M2 muscarinic ACh receptor-ACh-sensitive K+ channel signaling. In hypertensive rats, ANP concentration increased in the left ventricle but decreased in the right ventricle. The atrial concentration of ANP was not changed in hypertensive compared with normotensive rats. ANP mRNA expression was accentuated in the left ventricle but suppressed in the other cardiac chambers in the hearts of hypertensive rats. NPR-C expression was inversely related to ANP mRNA levels. Angiotensin II type 1 receptor (AT1R) expression was accentuated in the cardiac chambers from hypertensive rats compared with normotensive rats, whereas angiotensin II type 2 receptor, M2 muscarinic receptor, and Kir3.4 channels were suppressed. AT1R blockade with losartan reversed the change observed in hypertensive rats. The present findings indicate that renovascular hypertension shifts the major site of ANP secretion and synthesis from the atria to the left ventricle through modulation of the expression of ANP, NPR-C, AT1R, and the M2 muscarinic signaling pathway. NEW & NOTEWORTHY Renovascular hypertension suppresses the atrial secretion of ANP and shifts the major site of the regulation of ANP secretion and synthesis from atria to the hypertrophied left ventricle possibly via modulation of the expression of ANP, natriuretic peptide receptor-C, angiotensin II subtype 1 receptor, and M2 muscarinic signaling pathway.

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Okfalisa, Okfalisa, Hidayati Rusnedy, Dwi Utari Iswavigra, B. Pranggono, Elin Haerani Haerani, and Saktioto Saktioto. "DECISION SUPPORT SYSTEM FOR SMARTPHONE RECOMMENDATION: THE COMPARISON OF FUZZY AHP AND FUZZY ANP IN MULTI-ATTRIBUTE DECISION MAKING." SINERGI 25, no. 1 (November 11, 2020): 101. http://dx.doi.org/10.22441/sinergi.2021.1.013.

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Previous researches outlined the advantages of the Analytical Hierarchy Process (AHP) and Analytic Network Process (ANP) methods in solving Multi-Attribute Decision Making (MADM) problems. The advancement of the above methods was continually developed as an effort to cover up various weaknesses. Mainly related to the consistency and linguistic variables in translating the expert opinions. Thus, it initialized the emergence of Fuzzy AHP (F-AHP) and Fuzzy ANP (F-ANP). Due to the restricted operation of these algorithms in smartphone selection, this research attempted to investigate the effectiveness of both methods in providing the analysis of criteria weight, the final recommendation weight, the product recommendation weight, and the execution time in DSS-SmartPhoneRec application development. A survey of one hundred respondents of University students identified the dominant criteria in selecting the smartphone, namely price, Random Access Memory (RAM), processor, internal memory, and camera. Hence, five alternative products were then chosen as the appropriate smartphones’ recommendations based on the respondent’s preferences. As an automatic tool, a DSS-SmartPhoneRec application was built to analyze and compare between F-AHP and F-ANP methods in resolving the smartphone selection cases. It revealed that the level of consistency of criteria weight, the final weight of recommendation, and the weight that the product-based F-ANP was 40% greater than F-AHP. In terms of execution time, F-AHP had a shorter time than F-ANP. Meanwhile, the comparison of products recommendation from DSS-SmartPhoneRec and a manual test showed that F-ANP was 16% more in line with the respondents’ predilection. In a nutshell, the DSS-SmartPhoneRec administered the devote smartphone recommendations based on the user’s expectation. The comparison analysis furnished a learning outcome for the users in determining the appropriate MADM method tailored to the type of cases.

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Sun, Chun Ling, and Ran Bi. "An ANP Approach to Talent Management Evaluation Indices System." Key Engineering Materials 439-440 (June 2010): 1259–64. http://dx.doi.org/10.4028/www.scientific.net/kem.439-440.1259.

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Talent management has been regarded as a key component to organizations’ success recently. With the scope of this paper, talent management performance evaluation indices system was constructed. Analytic network process (ANP) has been adopted to model a multi-criteria talent management performance evaluation feedback system. Theoretical foundations and application processes of ANP were discussed and dependence and feedback among indices were analyzed. The result of ANP model for the indices system was obtained with Super Decisions software solution. ANP can solve problems with dependent indices effectively rather than analytic hierarchy process (AHP).

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Frajewicki, Victor, Luna Kahana, Haya Yechieli, Vera Brod, Ricardo Kohan, and Haim Bitterman. "Effects of severe hemorrhage on plasma ANP and glomerular ANP receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 5 (November 1, 1997): R1623—R1630. http://dx.doi.org/10.1152/ajpregu.1997.273.5.r1623.

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Atrial natriuretic peptide (ANP) plays an important role in blood volume and electrolyte homeostasis in normovolemia and in hypervolemic states. The currently available information on the effects of hypovolemia on plasma ANP is contradictory. Moreover, possible regulation of ANP receptors during severe hemorrhagic hypovolemia has not been investigated. This study evaluated the effects of severe hemorrhage on plasma ANP and on the regulation of glomerular ANP receptor subtypes in anesthetized rats. Constant rate bleeding of 50% of total blood volume within 2 h induced a reproducible shock state characterized by marked decreases in blood pressure, heart rate, and hematocrit and an increase in plasma renin activity and aldosterone. Hemorrhaged rats exhibited a gradual significant increase in plasma ANP from 39.3 ± 2.9 to 114.7 ± 20.0 pmol/l 1 h after the bleeding ( P< 0.001 from the initial value and P< 0.02 from the final value of sham-shock rats). Hemorrhage induced a significant decrease in total glomerular ANP binding sites (172 ± 25 vs. 363 ± 39 fmol/mg protein in hemorrhaged and sham-shock rats, respectively, P < 0.05). This decrease was mainly due to a significant decrease in ANPC receptors (132 ± 22 vs. 312 ± 40 fmol/mg protein in hemorrhaged and sham-shock rats, respectively, P < 0.05). Hemorrhage did not change glomerular ANPAreceptor density. No significant differences in the affinity of the glomerular receptor subtypes for ANP were detected. Our data indicate that plasma ANP increases after prolonged severe hemorrhage. It is suggested that downregulation of renal ANPC receptors leads to reduced clearance of ANP and contributes to elevation of its plasma level after severe hemorrhage.

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Wei, Jin Yu, Xin Li, and Ran Bi. "Using ANP to Do the Information Personnel Evaluation." Key Engineering Materials 439-440 (June 2010): 749–53. http://dx.doi.org/10.4028/www.scientific.net/kem.439-440.749.

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Information technology develops faster and faster, while the information talent have become more important than ever. The Analytic Network Process (ANP) was used in the paper for evaluation of the information personnel. ANP is a feedback and interdependence process developed on the basis of AHP and the SD software was used to calculate the ANP model. Evaluation results obtained in the paper can give suggestions to decision makers.

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Simanjorang, Alboin, Ahmad Perwira Mulia, and Ridwan Anas. "Prioritas Penanganan Jalan Nasional Menggunakan Metode AHP dan ANP: Ruas Jalan Batas Kota Rantau Prapat- Aek Nabara." Jurnal Health Sains 3, no. 2 (February 25, 2022): 297–313. http://dx.doi.org/10.46799/jsa.v3i2.386.

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Prioritas penanganan jalan didasarkan pada pertimbangan yang kompleks dengan mengakomodasi aspek yang bersifat teknis dan nonteknis. Pendekatan yang dapat mengakomodasi aspek yang bersifat multikriteria adalah Analytic Hierarchy Process (AHP) dan Analytic Network Process (ANP). AHP merupakan pendekatan yang bersifat preferrence dengan model yang berbentuk hirarki, sedangkan ANP merupakan pendekatan yang bersifat influence dengan model yang berbentuk jaringan. Tujuan dari penelitian ini adalah menentukan prioritas penanganan ruas jalan Batas Kota Rantau Prapat – Aek Nabara – Sp. Kota Pinang – Bts. Propinsi Riau dengan menggunakan metode AHP dan ANP menggunakan 4 (empat) kriteria. Data hasil analisis menunjukkan bahwa dari 4 (empat) kriteria yang diambil dalam penelitian ini dengan mengunakan metode AHP yakni faktor kondisi jalan (0,523) merupakan kriteria yang paling dominan, diikuti faktor biaya (0,261), faktor lalu lintas (0,141) dan kebijakan (0,075). Selanjutnya untuk memperoleh bobot akhir yang lebih objektif dilakukan analisis dengan metode ANP karena memungkinkan dilakukan feedback terhadap elemen dan klasternya sendiri yakni faktor kondisi jalan (0,4138) merupakan kriteria yang paling dominan, diikuti faktor biaya (0,2566), faktor lalu lintas (0,1846) dan kebijakan (0,1450). Berdasarkan hasil analisis dalam penentuan urutan prioritas dengan metode AHP, maka dapat diurutkan prioritas penanganan jalan nasional yaitu Ruas Batas Kota Rantau Prapat – Aek Nabara menjadi prioritas pertama kemudian diikuti Ruas Sp. Kota Pinang – Bts. Provinsi Riau dan Ruas Aek Nabara – Sp. Kota Pinang. Selanjutnya untuk mendapatkan hasil yang lebih stabil dan lebih akurat dalam penentuan urutan prioritas digunakan metode ANP dan didapatkan hasil yaitu Ruas Batas Kota Rantau Prapat-Aek Nabara menjadi prioritas pertama kemudian diikuti Ruas Sp. Kota Pinang-Bts. Provinsi Riau dan Ruas Aek Nabara-Sp. Kota Pinang. Perolehan urutan prioritas penanganan jalan dengan metode AHP pada penelitian ini sama hasilnya dengan menggunakan metode ANP.

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Hempel, Albrecht, Thomas Noll, Christoph Bach, Hans Michael Piper, Roland Willenbrock, Klaus Höhnel, Hermann Haller, and Friedrich C. Luft. "Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 5 (November 1, 1998): H1818—H1825. http://dx.doi.org/10.1152/ajpheart.1998.275.5.h1818.

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The atrial natriuretic peptide (ANP)-C receptor is generally believed to clear ANP; however, the ANP-C receptor may serve to reduce cAMP by inhibiting adenylate cyclase. ANP decreases endothelial permeability in coronary endothelial cell monolayers. We tested the hypothesis that part of this effect might be mediated by the ANP-C receptor. We used an endothelial cell monolayer from rat coronary endothelium and measured albumin flux. We applied either ANP or a ring-deleted ANP (C-ANP), which only stimulates the ANP-C receptor. ANP and C-ANP both decreased permeability from 100 pM to 100 nM by 60 and 30%, respectively. ANP increased endothelial cGMP contents 5.5-fold, whereas C-ANP had no effect. ANP reduced endothelial cAMP contents by 75%, which was only partly blocked by pertussis toxin. C-ANP also reduced cAMP; however, this effect was completely blocked by pertussis toxin. Protein kinase G inhibition blocked the ANP-mediated decrease in permeability by 50%. In contrast, pretreatment with pertussis toxin, in the face of protein kinase G inhibition, blocked the effect completely. C-ANP decreased permeability by half the amount of ANP. This C-ANP effect was completely blocked by pertussis toxin but not by protein kinase G inhibition. Isoproterenol (10 μM) increased permeability by almost 50%, which was completely blocked by ANP but only partially blocked by C-ANP. The C-ANP effect was blocked completely by pertussis toxin. Isoproterenol increased cAMP threefold, which was abolished by ANP. C-ANP reduced the isoproterenol-induced increase in cAMP by 50%. Isoproterenol had no effect on cGMP. We conclude that agonist binding to the ANP-C receptor inhibits cAMP production via a Giprotein-coupled signaling system. This inhibition may contribute to the decreased endothelial permeability evoked by ANP in this system.

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Sabrane, Karim, Markus-N. Kruse, Alexandra Gazinski, and Michaela Kuhn. "Chronic Endothelium-Dependent Regulation of Arterial Blood Pressure by Atrial Natriuretic Peptide: Role of Nitric Oxide and Endothelin-1." Endocrinology 150, no. 5 (January 29, 2009): 2382–87. http://dx.doi.org/10.1210/en.2008-1360.

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Atrial natriuretic peptide (ANP), via its guanylyl cyclase (GC)-A receptor, plays a key role in the regulation of arterial blood pressure (ABP) and volume. Endothelial-restricted deletion of GC-A in mice [endothelial cell (EC) GC-A knockout (KO)] resulted in hypervolemic hypertension, demonstrating that the endothelium participates in the hypotensive and hypovolemic actions of ANP. Published studies showed that ANP modulates the release of the vasoactive factors nitric oxide (NO) and endothelin-1 (ET-1) from cultured endothelia. Based on these observations, we examined the role of these endothelial factors in ANP-dependent vasodilatation (studied in isolated arteries) and chronic regulation of ABP (measured in awake mice by tail-cuff plethysmography). ANP induced concentration-dependent vasorelaxations of aortic, carotid, and pulmonary arteries. These responses were not different between control and EC GC-A KO mice, and were significantly enhanced after inhibition of NO synthase [by N(G)-nitro-l-arginine-methyl ester]. Intravenous administration of N(G)-nitro-l-arginine-methyl ester to conscious mice significantly increased ABP. The extent of these hypertensive reactions was similar in EC GC-A KO mice and control littermates (increases in systolic blood pressure by ∼25 mm Hg). Conversely, antagonism of ET-1/endothelin-A receptors with BQ-123 reduced ABP significantly and comparably in both genotypes (by ∼11 mm Hg). Finally, the vascular and tissue expression levels of components of the NO system and of immunoreactive ET-1 were not different in control and EC GC-A KO mice. We conclude that the endothelium, but not modulation of endothelial NO or ET-1, participates in the chronic regulation of ABP by ANP.

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Houng, Aiilyan K., Rachel A. McNamee, Attila Kerner, Pallavi Sharma, Almois Mohamad, Jonathan Tronolone, and Guy L. Reed. "Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 3 (March 2009): H655—H661. http://dx.doi.org/10.1152/ajpheart.00684.2008.

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Acute coronary artery occlusion triggers the release of atrial natriuretic peptide (ANP) from the heart. ANP affects vasodilation, natriuresis, and inflammation, but the integrated biological effects of ANP on myocardial infarction are unknown. To elucidate these effects, the left anterior coronary artery was ligated in anesthetized, ANP-deficient (ANP−/−) and congenic wild-type (ANP+/+) mice. The survival of ANP−/− mice was markedly better (56%) at 30 days postinfarction than the survival of ANP+/+ mice (20%, P < 0.01). Surviving mice were comparable initially, but ANP−/− mice developed more cardiac hypertrophy ( P < 0.001) and had lower contractility indexes 30 days after infarction ( P < 0.05). An analysis 24 h after coronary occlusion showed that ANP−/− mice had smaller infarcts than ANP+/+ mice (62.6 ± 12.1 vs. 100.8 ± 3.8%, P < 0.001) adjusted for comparable areas at risk for ischemia. The administration of ANP to ANP−/− mice via osmotic minipumps significantly enlarged infarct size to levels comparable with those observed in ANP+/+ mice ( P < 0.05). There was no difference in neutrophil migration into the noninfarcted myocardium of ANP−/− mice undergoing actual versus sham-operated coronary occlusion. By comparison, after coronary occlusion, the neutrophil infiltration into the myocardium was enhanced in ANP+/+ ( P < 0.0005) and ANP−/− mice administered ANP ( P < 0.0005). The expression of P-selectin, a molecule that mediates neutrophil adhesion, was significantly greater after coronary occlusion in the vasculature of ANP+/+ or ANP−/− mice treated with ANP than in ANP−/− mice ( P < 0.002). Taken together, these results indicate that ANP increases P-selectin, neutrophil infiltration, infarct size, and mortality following experimental coronary occlusion.

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St-Louis, Jean, and Ernesto L. Schiffrin. "Vasorelaxant effects of and receptors for atrial natriuretic peptides in the mesenteric artery and aorta of the rat." Canadian Journal of Physiology and Pharmacology 66, no. 7 (July 1, 1988): 951–56. http://dx.doi.org/10.1139/y88-155.

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Vasorelaxant effects of different atrial natriuretic peptides (ANP) were measured on rat aortic strips and mesenteric artery rings. These results were compared with the potency of the same peptides to displace 125I-labelled ANP (101–126) on membrane preparations of aorta and of mesenteric vascular bed. In aortic strips and mesenteric artery rings precontracted with phenylephrine (3 × 10−8 and 10−6 M, respectively), the order of potency of ANP was as follows: ANP (99–126) > ANP (101–126) > ANP (103–126) = ANP(103–125) [Formula: see text] ANP (103–123). In the displacement binding assays, the order of potency of ANP peptides was similar to that of the relaxation experiments: ANP (99–126) = ANP (101–126) > ANP (103–126) = ANP (103–125) [Formula: see text] ANP (103–123). When the vessels were precontracted by a smaller concentration of phenylephrine (10−7 M in mesenteric artery and 10−8 M in aorta), the IC50 of ANP (101–126) was significantly lower than when the higher concentration of phenylephrine was used. These results show that ANP receptors in the mesenteric artery and in the aorta have similar structural requirements, according to the order of potency of different length ANP, both for binding and myotropic responses.

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Zevenbergen, Bendert. "Geen nieuws: ANP verkocht." Advocatenblad 101, no. 6 (July 2021): 42. http://dx.doi.org/10.5553/ab/0165-13312021101006013.

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Rabenschlag, Franziska. "Advanced Nursing Practice (ANP)." Pflege 22, no. 03 (2009): 0233–34. http://dx.doi.org/10.1024/1012-5302.22.3.233.

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Bouteille, François, and Wolf-Dieter Krebs. "L'intégration de Framatome ANP." Revue Générale Nucléaire, no. 3 (May 2001): 24–29. http://dx.doi.org/10.1051/rgn/20013024.

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Journal articles on the topic 'ANP'

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