Dissertations / Theses on the topic 'Anni '70'
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Tartari, Francesca <1993>. "L'Horror giapponese dagli anni '50 agli anni '70 e il suo revival." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16042.
Full textMirolla, Chiara <1989>. "I rapporti tra Fiat e Cina dall'inizio degli anni '70 alla fine degli anni '80." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/3514.
Full textBaraldi, Matteo <1971>. "L'industria delle ombre: la short story fantastica nell'Australia degli anni '70." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/563/1/baraldi.pdf.
Full textBaraldi, Matteo <1971>. "L'industria delle ombre: la short story fantastica nell'Australia degli anni '70." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/563/.
Full textAntelmi, Giulia <1988>. "La politica estera americana nel golfo dagli anni 70 ai 90." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/4285.
Full textZocche, Nicola. "Il cinema di piombo : L`eredità degli anni di piombo nel cinema italiano dagli anni `70 ad oggi." Thesis, Umeå universitet, Institutionen för språkstudier, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136851.
Full textRuffino, Enrico <1992>. "Affrontare la realtà. Un percorso nella cultura e nelle biografie tra gli anni ’70 e gli anni ’80." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/12248.
Full textRuffino, Enrico <1992>. "Affrontare la realtà. Un percorso nella cultura e nelle biografie tra gli anni ’70 e gli anni ’80." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/12249.
Full textAmbrogio, Sofia <1991>. "Uno studioso nella Cina degli anni '70 I viaggi di Vincenzo Tusa." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15280.
Full textRolfin, Alessandra <1988>. ""Donna. Avanguardia femminista negli anni '70": radici artistiche di una mostra fotografica contemporanea." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/2945.
Full textCampagna, Elisa <1993>. "Gennadij Ajgi: la produzione degli anni '60-'70 nel panorama della neoavanguardia moscovita." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/12736.
Full textZanin, Manfredi <1993>. "I "triumviri monetales" degli anni 150-70 a.C. ca. Prospettive di una ricerca prosopografica." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/11542.
Full textMILANESI, SILVIA. "IL GRUPPO LOMBARDO DELL'UNIONE CRISTIANA IMPRENDITORI DIRIGENTI (UCID), DALLA FONDAZIONE (1945) AI PRIMI ANNI '70." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/61870.
Full textThe Gruppo Lombardo had been founded in Milan on 11th May 1945 by a group of people belonging to the Italian Catholic Action or to other Catholic bodies and that were, at the same time, important Lombard entrepreneurs, managers or bankers. The Association’s main aim was to spread among its members the knowledge of the principles of the Catholic social doctrine and to encourage their use in everyday working life. The Gruppo Lombardo was studied from its foundation up to the late 1960s/early 1970s. More precisely, because of the importance given by the Association to training and education, we focused on its initiatives in these fields; moreover, we examined also the case of the Segretariato UCID di Servizio sociale and of social workers belonging to this office but working for Giovanni Bassetti S. p. A.
MILANESI, SILVIA. "IL GRUPPO LOMBARDO DELL'UNIONE CRISTIANA IMPRENDITORI DIRIGENTI (UCID), DALLA FONDAZIONE (1945) AI PRIMI ANNI '70." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/61870.
Full textThe Gruppo Lombardo had been founded in Milan on 11th May 1945 by a group of people belonging to the Italian Catholic Action or to other Catholic bodies and that were, at the same time, important Lombard entrepreneurs, managers or bankers. The Association’s main aim was to spread among its members the knowledge of the principles of the Catholic social doctrine and to encourage their use in everyday working life. The Gruppo Lombardo was studied from its foundation up to the late 1960s/early 1970s. More precisely, because of the importance given by the Association to training and education, we focused on its initiatives in these fields; moreover, we examined also the case of the Segretariato UCID di Servizio sociale and of social workers belonging to this office but working for Giovanni Bassetti S. p. A.
Parisini, Roberto <1961>. "La città e i consumi. Consumi e trasformazioni urbane a Bologna tra anni '50 e '70." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4738/1/parisini_roberto_tesi.pdf.
Full textThe first chapter of this work deals with the actions carried on by local Administrators and a governmental board, the Chamber of Commerce, in order to understand the real characteristics of the local situation from an economic and social point of view and evaluate the perception and meaning of consumption and of urban areas involved. The most original aspect pointed out by the Administrators (eminent scholars such as Ardigo', Zangheri and Bellettini) is the great cultural and political homogeneity of the social scene. Despite the massive immigration, proportionally second most important only after Milan, but mainly coming from the same province or, at most, from the region and with similar social and development experience. Starting from this homogeneity (second chapter) the Boards of Bologna tried to manage the town transformation and the increase of consumption s, which sometimes seemed to be distorted and excessive. Working on the big crisis of 1963-1965 and 1873-1977, local administrators tried to obtain their legitimization grounded on consumption, aware of the new trend arriving, but deeply concerned to limit the breaking effects on the local fabric and to address the gaining efforts of “Bolognesi” by a governance fed by city planning. Delays, common claims, law and burocratic obstacles made this way really hard and not linear up to the '80s, when the trend changed. The third chapter visualizes the map of the expansion of commercial areas during the most important boom phases, by using GIS.
Parisini, Roberto <1961>. "La città e i consumi. Consumi e trasformazioni urbane a Bologna tra anni '50 e '70." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4738/.
Full textThe first chapter of this work deals with the actions carried on by local Administrators and a governmental board, the Chamber of Commerce, in order to understand the real characteristics of the local situation from an economic and social point of view and evaluate the perception and meaning of consumption and of urban areas involved. The most original aspect pointed out by the Administrators (eminent scholars such as Ardigo', Zangheri and Bellettini) is the great cultural and political homogeneity of the social scene. Despite the massive immigration, proportionally second most important only after Milan, but mainly coming from the same province or, at most, from the region and with similar social and development experience. Starting from this homogeneity (second chapter) the Boards of Bologna tried to manage the town transformation and the increase of consumption s, which sometimes seemed to be distorted and excessive. Working on the big crisis of 1963-1965 and 1873-1977, local administrators tried to obtain their legitimization grounded on consumption, aware of the new trend arriving, but deeply concerned to limit the breaking effects on the local fabric and to address the gaining efforts of “Bolognesi” by a governance fed by city planning. Delays, common claims, law and burocratic obstacles made this way really hard and not linear up to the '80s, when the trend changed. The third chapter visualizes the map of the expansion of commercial areas during the most important boom phases, by using GIS.
Garbari, Silvia <1972>. "Cappuccetto rosso si è persa. Giovani e politica a Borgo Valsugana alla fine degli anni '70." Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/7463.
Full textFabris, Andrea Angelo <1996>. "L'analisi della crisi energetica degli anni ''70 a confronto con la crisi in corso nell'ultimo triennio (2020-2022)." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21910.
Full textTonolo, Chiara <1994>. "Non per amore, ma per denaro. La questione del lavoro domestico in Italia dagli anni ’70 alla pandemia del 2020." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19599.
Full textTurrini, Veronica <1997>. "Amin Faqiri e la letteratura regionale in Iran fra gli anni 1960-70. Tre racconti dal volume Dehkade-ye pormalāl: traduzione e analisi." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21333.
Full textCoco, Agnese <1997>. "L’animazione come strumento di propaganda e di critica sociale, con un focus specifico sulla retorica politica dell’animazione sovietica negli anni ’60 e ‘70." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21455.
Full textFOIS, SARA. "Sistemi di appropriazione e approcci alla riqualificazione delle megastrutture per l'edilizia residenziale pubblica negli anni 60-70. Il caso del quartiere Sant’Elia a Cagliari." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266548.
Full textGENTILE, FRANCESCA. "COMUNITA' ESTETICHE E COMUNITA' ETICHE IL TEATRO DI GRUPPO IN ITALIA IL CASO DEL TEATRO DEL MAGOPOVERO (1971-1989)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2008. http://hdl.handle.net/10280/264.
Full textThe research goes trough the Italian scene in - between the 70's and the 80's, in particular it focuses on the group's theatre: teams who experimented deeply a community action with a theatre instrument. The study takes as example the “Teatro del Magopovero”, now “Casa degli Alfieri”, one of the most interesting theatre groups of Piedmont, as a significant occurrence of the artistic and social phenomena of the theatre of the last century which aims to the ensemble . This group was founded in the 70's as a community-based theatre: it's an interesting instance of group /team working and social action. The evolution of the team building of this group shows the changes in the Italian history and stresses out how the strong ethic goal of this groups has been able to change in a aesthetic element, keeping high attention to the cultural and social network with the community in their performances.
GENTILE, FRANCESCA. "COMUNITA' ESTETICHE E COMUNITA' ETICHE IL TEATRO DI GRUPPO IN ITALIA IL CASO DEL TEATRO DEL MAGOPOVERO (1971-1989)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2008. http://hdl.handle.net/10280/264.
Full textThe research goes trough the Italian scene in - between the 70's and the 80's, in particular it focuses on the group's theatre: teams who experimented deeply a community action with a theatre instrument. The study takes as example the “Teatro del Magopovero”, now “Casa degli Alfieri”, one of the most interesting theatre groups of Piedmont, as a significant occurrence of the artistic and social phenomena of the theatre of the last century which aims to the ensemble . This group was founded in the 70's as a community-based theatre: it's an interesting instance of group /team working and social action. The evolution of the team building of this group shows the changes in the Italian history and stresses out how the strong ethic goal of this groups has been able to change in a aesthetic element, keeping high attention to the cultural and social network with the community in their performances.
Wiley, James A. "Monoclonal anti-idiotypes induce neutralizing antibodies to enterovirus-70 conformational epitopes." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7649.
Full textWeber, Malte. "Cloning and characterisation of anti-Scl-70 autoantibodies for the diagnosis of systemic sclerosis." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13054.
Full textSystemic sclerosis (SSc) is a rare autoimmune disease characterised by inflammation and fibrosis of many organs. One of three major autoantibodies is the anti-Scl-70 autoantibody that recognises the nuclear enzyme topoisomerase I (topo I). This autoantibody is diagnostic and clinical significance because it is present in up to 30% of SSc patients and it's appearance is linked to pulmonary fibrosis. One part of the diagnosis of SSc is made by autoantibody assays for which anti-Scl-70 reference sera are used as internal standards. These reference sera are available only in small quantities and are of highly variable autoantibody content which makes them unsuitable for international use. In order to guarantee international assay comparability it is necessary to develop standards of well-defined specificity and standard composition. With the aim of generating such a standard for anti-Scl-70 antibody assays, we first attempted to provide high quality antigen for antibody isolation by stably expressing human topo I in CHO and 293 cells. Subsequently, we developed a new strategy for successful isolation of antibody fragments (scFv) from small patient blood samples by combining human B cell culture and phage display. We isolated 5 scFvs that are highly specific for topo I. These scFvs are heterogeneous in terms of sequence diversity, affinities, and antigen recognition. Our findings underline that the process of autoantibody generation in SSc is highly complex and that antigen source and quality determines the efficiency of autoantibody detection. In addition, the suitability as standard of two of these scFvs converted into full length antibodies was assessed. These full-length antibodies did not retain antigen specificity and could not been used as a standard for the diagnostic of SSc. However, the identified scFvs might be used as a standard in form of a scFv-Fc fusion
Naslet, Véronique. "Les anticorps anti-DNA-topoisomérase I ou anti-Scl-70 : étude par immunoblot, comparaison de quatre méthodes de détection, à propos de 42 cas." Paris 5, 1994. http://www.theses.fr/1994PA05P222.
Full textOliveira, Rodrigo Carvalho de. "Imunopatogenia do lúpus eritematoso sistêmico na bahia: envolvimento de autoanticorpos e prolactina." Universidade Federal da Bahia, 2015. http://repositorio.ufba.br/ri/handle/ri/22991.
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O lúpus eritematoso sistêmico (LES) é uma doença reumática autoimune que pode acometer uma em cada 1.700 mulheres brasileiras. Trata-se de doença cuja etiologia se fundamenta na associação da predisposição genética dos pacientes com fatores ambientais e hormonais, perda da tolerância imunológica e propagação da autorreatividade inata e adaptativa, resultando em manifestações clínicas complexas e multivariadas. Diversos aspectos associados com a atividade do LES, especialmente a doença renal presente em importante proporção dos pacientes, têm sido objeto de intensa investigação. Entre estes, a participação de autoanticorpos e a contribuição de componentes bioativos como citocinas e hormônios na nefrite lúpica ocupam posição de destaque. Objetivo: No presente estudo foi investigada a participação dos anticorpos anti-dsDNA totais e de alta avidez, antinucleossomo (ANuA) e hiperprolactinemia na atividade do LES e nas suas manifestações clínicas com destaque para Artropatia de Jaccoud, usando como população alvo mulheres lúpicas residentes na Bahia. Material e Métodos: Cento e quarenta e duas mulheres portadoras de LES foram investigadas para a prevalência e níveis de anticorpos anti-dsDNA totais, anticorpos anti-dsDNA de alta avidez e ANuA, além de hiperprolactinemia. Adicionalmente, foram testadas as correlações dos níveis destes componentes com a atividade da doença e suas associações com as manifestações clínicas mais prevalentes nestas pacientes. Autoanticorpos antinucleares foram determinados por testes de imunofluorescência indireta e ELISA. Níveis séricos de prolactina e citocinas foram determinados por imunoensaios de captura de antígeno, enquanto os níveis de C3 e C4 foram determinados por imunonefelometria. Os níveis de creatinina e proteinúria foram medidos por métodos colorimétricos e a atividade lúpica avaliada com o protocolo SLEDAI-2K. Testes de estatística univariada foram usados nas análises dos resultados. Resultados: Os níveis de anticorpos anti-dsDNA de alta avidez e de anti-dsDNA totais se correlacionaram diretamente com os níveis de anticorpos antinucleossomo, sendo esta correlação mais forte com os primeiros. Correlações significativas entre os níveis de C3, C4, VHS, proteinúria e SLEDAI foram observadas com os níveis de anticorpos anti-dsDNA de alta avidez e, exceto proteinúria, com os níveis de ANuA. Os níveis de anticorpos anti-dsDNA totais se correlacionaram apenas com os níveis de C3 e SLEDAI, porém de forma menos significativa que os anticorpos anti-dsDNA de alta avidez e ANuA. Pacientes com artropatia de Jaccoud apresentaram níveis mais altos de anticorpos antidsDNA totais e IL-6. Hiperprolactinemia leve a moderada foi encontrada em 19,7% das pacientes, observando-se níveis séricos de prolactina mais altos nas pacientes com comprometimento renal, além de existir correlação entre os níveis séricos deste hormônio com os níveis de creatinina sérica e proteinúria. Adicionalmente, existiu uma aparente supressão da produção de anticorpos anti-RNP- 70 em pacientes lúpicas hiperprolactinêmicas com fenômeno de Raynaud. Conclusões: Anticorpos anti-dsDNA constituem-se em importantes biomarcadores de doença ativa em pacientes portadoras de LES residentes na Bahia, podendo complementar o diagnóstico da artropatia de Jaccoud nestas pacientes, além de sugerir a presença de comprometimento renal quando são de alta avidez e detectados conjuntamente com proteinúria e baixos níveis de C3. Por outro lado, a presença de uma hiperprolactinemia leve a moderada pode ser verificada nestas mulheres, cujo envolvimento na doença renal lúpica foi demonstrado neste estudo, além de inibir a produção de anticorpos anti- RNP-70.
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease that affect one in 1,700 Brazilian women. This disease is associated with a genetic predisposition of the patients and has the contribution of hormonal and environmental factors. Lupus' patients have a loss of immune tolerance, resulting in uncontrolled autoimmune reactivity and complex and multivariate clinical manifestations. Various aspects associated with the activity of SLE, especially kidney disease, have been the subject of intense investigation. Among these, the participation of autoantibodies and the contribution of bioactive components such as cytokines and hormones occupy a prominent position in these studies. Objective: The present study investigated in SLE women who lived in Bahia (Brazil), the participation of total and high avidity dsDNA, antinucleosome antibodies (ANuA) and hyperprolactinemia in the activity of this disease and its clinical manifestations, especially arthropathy of Jaccoud. Material and Methods: One hundred and forty-two women with SLE were investigated for the presence of hyperprolactinemia and prevalence and levels of total and high avidity anti-dsDNA antibodies and ANuA. Correlations among these components with biomarkers of lupus activity and their associations with the most prevalent clinical manifestations in the patients were also tested. Indirect fluorescent antibody test and ELISA determined antinuclear autoantibodies. Capture immunoassays measured prolactin and cytokine levels while C3 and C4 levels were determined by immunonephelometric tests. Creatinine levels and proteinuria were measured by colorimetric methods and lupus activity assessed with the SLEDAI-2K protocol. Descriptive statistical tests were used in the analyses of the results. Results: The levels of both high avidity and total anti-ds DNA antibodies correlated directly with the levels of antinucleosome antibodies, but this correlation was stronger with dsDNA antibodies of high avidity. Significant correlations among the levels of C3, C4, ESR, proteinuria and SLEDAI were observed with the levels of anti-dsDNA antibodies of high avidity and, except proteinuria, with ANuA levels. The levels of total anti-dsDNA antibodies correlated only with levels of C3 and SLEDAI, but these correlations were lesser than those of high avidity dsDNA antibodies and ANuA. Patients with Jaccoud arthropathy presented higher levels of dsDNA antibodies and IL-6, whereas mild to moderate hyperprolactinemia was found in 19.7% of the lupus patients. Higher serum levels of prolactin were demonstrated in patients with kidney disease, as well as there was a correlation between the levels of this hormone with their serum levels of creatinine and urine protein. In addition, hyperprolactinemia seems to inhibit the production of anti-RNP-70 autoantibodies. CONCLUSIONS: Antibodies to dsDNA are important biomarkers of active disease in SLE patients from Bahia and the increase in dsDNA antibody levels can complement the diagnosis of Jaccoud’s arthropathy. In addition, high avidity dsDNA autoantibodies are a good laboratory evidence of renal impairment in lupus patients when they are detected together with proteinuria and low levels of C3. On the other hand, the presence of a mild to moderate hyperprolactinaemia can be seen in lupus women whose involvement in lupus kidney disease and inhibition of the production of RNP-70 autoantibodies was demonstrated in this study.
Perissinotto, Silvia <1990>. "Il task-based approach nasce negli anni '80 del secolo scorso e negli anni ha trovato ampio riscontro a livello mondiale. E' attualmente uno degli approcci maggiormente utilizzati nel campo dell'insegnamento linguistico grazie alla sua natura comunicativa; trova infatti le sue radici nel Communicative Language Teaching degli anni '70 con il quale condivide la forte contrapposizione per gli approcci basati sull'esposizione di rigide regole grammaticali. L'biettivo comunicativo che ci si pone nella progettazione dei task è strettamente legato all'autenticità delle attività, ovvero la loro concretezza e capacità di riprodurre situazioni di vita reale. L'approccio per task è fonte di ricerca in quanto dimostra essere particolarmente proficuo nelle classi di L2 e LS: i maggiori effetti sono riscontrabili sul miglioramento delle abilità comunicative dei discenti. Se da una parte la letteratura sul task-based approach è molto ampia e in fase di continua sperimentazione, un aspetto più ristretto che è stato considerato in misura minore è la sua efficacia all'interno di classi di principianti (basic user, secondo il quadro comune europeo di riferimento per la conoscenza delle lingue: livelli A1 e A2). Pochi ricercatori hanno finora investigato gli effetti dell'utilizzo di task su questo campo di discenti e i principali risultati ottenuti sono legati alle abilità di comprensione. Operando con apprendenti la competenza linguistica è ai primi stadi di sviluppo l'applicazione di attività di comprensione risulta limitante: è a questo proposito che l'orientamento suggerito dai ricercatori è quello di impiegare dapprima dei task che favoriscano la comprensione linguistica per poi passare ad attività di produzione. Gli effetti dei task di comprensione sono ancora una questione in fase di ricerca." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/12962.
Full textLONARDELLI, LUIGIA. "Operare e documentare: l'Associazione Incontri Internazionali d'Arte, Roma 1970-1981." Doctoral thesis, 2012. http://hdl.handle.net/2158/871538.
Full textFONTANA, CHIARA. "Un’analisi linguistica, retorica e metrica dell’opera sperimentale di Naǧīb Surūr: La “seconda nahḍa” degli anni ’60 e ’70 e l’evoluzione del testo in ʻāmmiyya e fuṣḥā." Doctoral thesis, 2018. http://hdl.handle.net/11573/1063151.
Full textGrizoste, Weberson Fernandes. "Reflexos anti-épicos de Virgílio no indianismo de Gonçalves Dias." Master's thesis, 2009. http://hdl.handle.net/10316/13351.
Full textO objetivo deste trabalho é analisar o conceito anti-épico no indianismo de Gonçalves Dias. Partiremos da premissa já desenvolvida em torno da obra Eneida de Virgílio, que, para muitos autores, embora pretendesse o poeta compor um poema de vida, acabou por compor um poema cheio de sofrimentos e de morte. A contradição que submergiu Virgílio também a ela sucumbira Gonçalves, embora o poeta quisesse fazer de seu indianismo uma celebração da vida, sua nostalgia ganha um pessimismo bastante peculiar, porque ao relembrar um tempo em que os nativos viviam felizes coloca em pauta o triste destino que os aguardava, e que Gonçalves tenta fugir, mas se torna inevitável. Este pessimismo encontra-se na própria autodenominação do poeta: cantor de um povo extinto e humilde cantor
Sharma, Umender K. "Mechanism Of Interaction Of Escherichia Coli σ70 With Anti-Sigma Factors." Thesis, 2007. http://hdl.handle.net/2005/578.
Full textLin, Chia-Yi, and 林佳儀. "Analysis of Anti-Heat Shock Protein 60, -70 and -90 Autoantibodies in Patients with Manic Episode." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/09865207747787304007.
Full text台北醫學院
細胞及分子生物研究所
90
A close interaction between the central nervous system and the immune system have evidenced in many documents, in which we have paid attention to the study of immunological abnormalities both in psychological stress and patients with psychotic disorder. More specifically, an autoimmune mechanism was suggested as one of the possible factors in the pathogenesis of schizophrenia. The aim of this study was to investigate the presence of antibodies that react with heat shock proteins (Hsps) in sera from patient with mania. The sera were tested for antibodies binding to cell extracts of U-373MG glioblastoma cell line using western blot analysis. Hsps are intracellular proteins in most cells which are thought to serve protective functions against infection and cellular stress. In some instances, Hsps may be aberrantly expressed on target tissues interaction with the immune system might potentially result in autoimmune disease, as suggested in juvenile diabetes mellitus or rheumatoid arthritis. In the part of autoantibodies against Hsp90, we observed that un-medicated acute patients were significantly higher compared with remission patients. Sera anti-Hsp90 autoantibodies in medicated acute patients were significantly lower compared with un-medication acute patients. Sera anti-Hsp 70 and 90 autoantibodies in medicated acute patients were significantly lower compared with normal controls. In addition, there was no significant difference on autoantibodies against Hsp60 between patients and normal controls . We suggested that a presence of abnormal immune reactivity involving Hsp90 in patients with manic acute episode, and it may implicate in pathogenesis in acute episode with this disease.
Chen, Pin-Jun, and 陳品君. "The Study of the in Vitro Antioxidant and Anti-Inflammatory Activities of the Water and 70% Ethanol Extracts of Phyllanthus Emblica L." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/09008929189167765612.
Full text嘉南藥理大學
保健營養系
103
Abstract The objectives of this study were to investigate the in vitro antioxidative and antiinflammatory activities of the 70% ethanol and water extracts of the Phyllanthus Emblica L. The amount of the polyphenol and flavone of the 70% ethanol and water extracts of the Phyllanthus Emblica L. determined in this study were 178.2 ± 0.66 Gallic acid Equivalent/g (GAE/g), 116.73 ± 2.26 GAE/g, 12.30 ± 1.30 Quecetin Equivalent/g (QE/g) and 8.05 ± 1.07 QE/g. The results from this experiment of Trolox Equivalent Antioxidant Capacity (TEAC), Reducing Power, and Scavenging effect of DPPH radicals show that 70% ethanol extracts of the Phyllanthus Emblica L. work better than the water extracts of the Phyllanthus Emblica L. Both of the 70% ethanol and water extracts of the Phyllanthus Emblica L. show low chelating abilities on ferrous ions. The amount of interleukin-6 (IL-6) produced by RAW264.7 cells treated with lipopolysaccharides (LPS) were significantly decreased (70%, and 60%) by the 70% ethanol and water extracts of the Phyllanthus Emblica L. at the concentration of 100 μg/mL. Moreover, the amount of the interleukin-12 (IL-12) produced by RAW264.7 cells treated with LPS were significantly increased (20%) by the 70% ethanol and water extracts of the Phyllanthus Emblica L. at the concentration of 800 μg/mL. There were no obvious effects on the production of tumor necrosis factor alpha (TNF-α) by the extracts of the Phyllanthus Emblica L. The amounts of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) produced by RAW264.7 cells treated with LPS were significantly decreased by the 70% ethanol and water extracts of the Phyllanthus Emblica L. at the concentration of 200 μg/mL and 100 μg/mL. Based on these information the 70% ethanol extracts of the Phyllanthus Emblica L. has a better antioxidative activities than the water extracts of the Phyllanthus Emblica L. Both of the 70% ethanol and water extracts of the Phyllanthus Emblica L. show antiinflammatory effects on the LPS treated RAW264.7 cells .
徐志文. "Transcriptional regulation of heat shock protein 70 and anti-apoptotic mechanism of glucose regulated protein 78 in stressed non-small cell lung cancer H460 cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/64247072087233568802.
Full text國立清華大學
生命科學系
95
Heat shock proteins (HSPs) are a defined set of genes response to a variety of external stimuli and their products are mainly molecular chaperones that are crucially involved in the maintenance of the proper functions of a large range of intracellular proteins. The stress proteins are usually sub-classified a number of HSPs families according to their molecular weight. Among them, the HSP70s is one of the most important HSPs families and highly associated with tumor transformation because of its anti-apoptotic function. However, the detailed mechanisms of HSP70s in gene regulation and anti-apoptosis are not fully understood. First of all, we examined gene regulation of HSP70s in geldanamycin (GA, a potent anti-cancer drug)-treated human non-small cell lung cancer H460 cells. In this study, we showed that the HSP70-1/2 are the major inducible forms under GA treatment using LC-ESI-MS/MS and Northern blotting analysis. Transactivation of HSP70-1/2 was further determined by electrophoretic mobility-shift assay using heat shock element as a probe. The signaling pathway mediators involved in HSP70-1/2 transactivation were screened by the kinase inhibitor scanning technique. The protein kinase C (PKC)-specific inhibitor Ro-31-8425 and the Ca2+-dependent PKC inhibitor Gö-6976 diminished GA-induced HSP70-1/2, suggesting an involvement of the PKC in the process. Moreover, GA treatment causes a transient increase of intracellular Ca2+. Chelating intracellular Ca2+ with BAPTA-AM or depletion of intracellular Ca2+ store with A23187 or thapsigargin significantly decreased GA-transactivated HSP70-1/2 expression. Taken together, our results demonstrated that GA induces specific HSP70-1/2 isoforms expression in H460 cells through signaling pathway mediated by Ca2+ and PKC. On the other hand, the chaperone glucose-regulated protein 78 (GRP78), a member of HSP70s, protects cells from cytotoxicity induced by DNA damage or endoplasmic reticulum (ER) stress. In this study, we showed that GRP78 is a major inducible protein in H460 cells treated with ER stress inducers including A23187 and thapsigargin. 4-[2-aminoethyl]-benzenesulfonyl fluoride hydrochloride (AEBSF), an inhibitor of serine protease, diminished GRP78 induction, enhanced mitochondrial permeability and augmented apoptosis in H460 cells during ER stress. Simultaneously, AEBSF promoted Raf-1 degradation and decreased phosphorylation level of Raf-1 at Ser338 and/or Tyr340 during ER stress. His-tag affinity pull-down assay and subcellular fractionation results also demonstrated that GRP78 associateed and colocalized with Raf-1 on the outer membrane of mitochondria. Treatment of cells with ER stress inducers inactivated Bcl-XL/Bcl-2-associated death promoter (BAD) by phosphorylation at Ser75, which is a phosphorylation site by Raf-1. Nevertheless, AEBSF attenuated phosphorylation of BAD leading to cytochrome c release from mitochondria. Additionally, overexpression of GRP78 and/or Raf-1 protected cells from ER stress-induced apoptosis. These results indicate that GRP78 may chaperone Raf-1 to maintain mitochondrial permeability and thus protects cells from ER stress-induced apoptosis. Taken together, we discovered that molecular mechanisms of HSP70s in gene regulation and anti-apoptotic function. These findings might provide a possible pharmacological manipulation for cancer exposed to chemotherapy.