To see the other types of publications on this topic, follow the link: Anhedonia.
Journal articles on the topic 'Anhedonia'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Anhedonia.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Mazo, G. E., and A. O. Kibitov. "Anhedonia as a basic syndrome and a target for treatment for depressive disorder." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 3 (October 6, 2019): 10–18. http://dx.doi.org/10.31363/2313-7053-2019-3-10-18.
Full textAbstract:
The article presents an analytical review aimed at determining the effect of anhedonia on the course and therapeutic prognosis of depression. Currently, there is no specific pharmacological approach to the treatment of anhedonia in depression.It is clear all antidepressants that affect the symptoms of depression in general act to a certain extent on anhedonia. Modern views on the biological mechanisms involved in the formation of anhedonia are described, on the basis of which a search for drugs with anti-anhedonic activity is possible. Vortioxetine can be considered as an antidepressant with a specific anti-anhedonic effect.
2
De Fruyt, Jürgen, Bernard Sabbe, and Koen Demyttenaere. "Anhedonia in Depressive Disorder: A Narrative Review." Psychopathology 53, no. 5-6 (2020): 274–81. http://dx.doi.org/10.1159/000508773.
Full textAbstract:
Since the introduction of DSM-III anhedonia has become a core depressive criterion and is defined as the loss of interest or pleasure. Although the origin of the word goes back to the end of the 19th century and numerous anhedonic symptoms are described in classic texts on depression, this centrality in the diagnosis of depression is only recent. Anhedonia is best described as a symptom complex with unclear boundaries cutting across the tripartite model of the mind (affect, volition, and cognition). Popular concepts of anhedonia pertain to the pleasure cycle and positive affectivity. These concepts partially overlap and are often mixed up, but clearly stem from different theoretical backgrounds: the affective science of reward processing versus more general, dimensional modelling of affect. The former concept seems more suitable to understand anhedonic emotions, the latter more suitable to understand anhedonic mood or trait. This narrative review covers the history of “anhedonia,” the different anhedonic phenomena, and psychopathological concepts. An attempt is made to go beyond a merely descriptive psychopathology. Neurobiological and psychological insights shed a light on how symptoms are made and interconnected; these insights possibly call for a new psychopathological language.
3
Mendelevich, Vladimir D. "Understanding of anhedonia: from traditional to phenomenological analysis of the phenomena." Neurology Bulletin LIII, no. 3 (December 4, 2021): 44–50. http://dx.doi.org/10.17816/nb78185.
Full textAbstract:
The article is written in the form of a survey lecture highlighting the modern views of scientists on the phenomenon of anhedonia. A comparative analysis of the traditional psychiatric view of anhedonia with the phenomenological one is carried out. The specificity of anhedonia as a psychopathological symptom and as a psychological phenomenon is shown, as well as the features of the manifestation of anhedonia in neurological diseases. For practicing psychiatrists, the aspect of differentiation of anhedonia may be important, allowing one to choose the most adequate ways of correcting it between psychotherapeutic interventions, prescribing antidepressants with a proven anti-anhedonic effect or atypical antipsychotics.
4
Hein, Matthieu, François-Xavier Dekeuleneer, Olivier Hennebert, Dephine Skrjanc, Emilie Oudart, Anaïs Mungo, Marianne Rotsaert, and Gwenolé Loas. "Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression." International Journal of Environmental Research and Public Health 19, no. 23 (December 2, 2022): 16147. http://dx.doi.org/10.3390/ijerph192316147.
Full textAbstract:
The aim of the study was to explore in depression the relationship between recent suicidal ideation and the different anhedonias taking into account the severity of depression. Recent studies have suggested that recent change of anhedonia and not state or trait anhedonia is associated with recent suicidal ideations even when the level of depression is controlled. Three samples were used (74 severe major depressives, 43 outpatients with somatic disorders presenting mild or moderate depression and 36 mild or moderate depressives hospitalized in the intensive coronary unit). Recent change of anhedonia was rated by the anhedonia subscale of the Beck Depression Inventory (BDI-II), state anhedonia by the Snaith–Hamilton Pleasure Scale (SHAPS), trait anhedonia by the TEPS (Temporal Experience of Pleasure Scale), musical anhedonia by the BMRQ (Barcelona Music Reward Questionnaire), social recent change of anhedonia by the SLIPS (Specific Loss of Interest and Pleasure Scale), the severity of depression by the BDI-II and the distinction between melancholic and non-melancholic was found using a subscale of the BDI-II. Bivariate and multivariate regression analyses were performed in each sample. In severe major depressives and, notably, in melancholia, recent suicidal ideation was associated with trait anhedonia; however, in mild or moderate depression, recent suicidal ideation was associated with recent change of anhedonia. Musical anhedonia and social recent change of anhedonia were not associated with recent suicidal ideation. Trait anhedonia could be, in severe depression, a strong predictor of recent suicidal ideation.
5
Hyldelund, Nikoline Bach, Derek Victor Byrne, Raymond C. K. Chan, and Barbara Vad Andersen. "The Relationship between Social Anhedonia and Perceived Pleasure from Food—An Exploratory Investigation on a Consumer Segment with Depression and Anxiety." Foods 11, no. 22 (November 16, 2022): 3659. http://dx.doi.org/10.3390/foods11223659.
Full textAbstract:
Anhedonia, the diminished ability to experience pleasure, is a key symptom of a range of mental and neurobiological disorders and is associated with altered eating behavior. This research study investigated the concept of anhedonia in relation to mental disorders and the perception of pleasure from food to better understand the link between anhedonia and eating behavior. A consumer survey (n = 1051), including the Food Pleasure Scale, the Chapman Revised Social Anhedonia Scale, the Patient Health Questionnaire, and the Generalized Anxiety Disorder scale, was conducted to explore the perception of pleasure from food among people with anhedonic traits. Comparative analyses were performed between people with symptoms of depression and/or anxiety and people with no symptoms of these conditions. A segmentation analysis was furthermore performed based on three levels of anhedonia: Low, Intermediate and High anhedonia. Thus, insights into how food choice and eating habits may be affected by different levels of anhedonia are provided for the first time. Our findings showed that the ‘Low anhedonia’ segment found pleasure in all aspects of food pleasure, except for the aspect ‘eating alone’. ‘Eating alone’ was, however, appreciated by the ‘Intermediate anhedonia’ and ‘High anhedonia’ segments. Both the ‘Intermediate anhedonia’ and ‘High anhedonia’ segments proved that their perceptions of food pleasure in general were affected by anhedonia, wherein the more complex aspects in particular, such as ‘product information’ and ‘physical sensation’, proved to be unrelated to food pleasure. For the ‘High anhedonia’ segment, the sensory modalities of food were also negatively associated with food pleasure, indicating that at this level of anhedonia the food itself is causing aversive sensations and expectations. Thus, valuable insights into the food pleasure profiles of people with different levels of anhedonia have been found for future research in the fields of mental illness, (food) anhedonia, and consumer behaviors.
6
Nizet, Laurie, Xavier Montana, Jean-Pol Lanquart, and Gwenolé Loas. "Research into an Association between Anhedonia and Decreased REM Latency in Moderately to Severely Depressed Patients." Sleep Disorders 2018 (July 2, 2018): 1–6. http://dx.doi.org/10.1155/2018/1636574.
Full textAbstract:
Anhedonia stands as a core symptom and potential trait marker of major depressive disorder (MDD). The importance of rapid eye movement sleep latency (REML) as a biological marker of depression has previously and repeatedly been studied. The aim of this paper is to analyse the relationship between anhedonia and REML in moderately to severely depressed patients. The shortened Beck Depression Inventory (BDI-13) was chosen to assess depressive symptoms and, among them, more particularly, anhedonic symptoms. Two-way ANCOVA was used for statistical analyses. A significant association between anhedonic symptoms and REML was found when the number of sleep cycles (NCy) and the severity of depression were added as covariates. Our findings suggest that REML may be a useful variable to differentiate some diagnostic subtypes of depression related to anhedonia.
7
Minichino, A., M. Jackson, P. Burnet, and B. Lennox. "The gut-microbiome-endocannabinoid axis and anhedonia/amotivation: A mediation analysis in a general population cohort." European Psychiatry 64, S1 (April 2021): S131. http://dx.doi.org/10.1192/j.eurpsy.2021.365.
Full textAbstract:
IntroductionGeneral-population studies investigating the biological correlates of anhedonia/amotivation might be informative for treatment breakthroughs for a number of clinical conditions. Reduced gut-microbial diversity might lead to an anhedonic/amotivational syndrome (“sickness behaviour”). However, how gut-microbial diversity contribute to this clinical phenotype is a key gap in knowledge. We hypothesised the endocannabinoid system would be at play.ObjectivesWe tested the hypothesis that the endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivationMethodsSecondary data analysis on 786 volunteer twins (TwinsUK). Measures of gut-microbiome, faecal endocannabinoid metabolites, and anhedonia/amotivation were collected over five years. To test our hypothesis we used a multilevel mediation model using alpha diversity as predictor, faecal levels of the endocannabinoid palmitoylethanolamide (PEA) as mediator, and anhedonia/amotivation as outcome. Analyses were adjusted for obesity, diet, antidepressants, and sociodemographic covariates.ResultsMean age was 65.2±7.6; 27% were obese and 4.7% were on antidepressants. Alpha diversity was significantly associated with anhedonia/amotivation (β=-0.37; 95%CI: -0.71 to -0.03; P=0.03). Faecal PEA levels mediated this association: the indirect effect was significant (β=-0.13; 95%CI: -0.24 to -0.01; P=0.03), as was the total effect (β=-0.38; 95%CI: -0.72 to -0.04; P=0.03). The direct effect of alpha diversity on anhedonia/amotivation was attenuated fullyConclusionsWe provided the first evidence showing that the association between gut-microbial features and anhedonia/amotivation is mediated by the endocannabinoid system. These findings shed light on a new therapeutic target in an area of unmet clinical need.DisclosureNo significant relationships.
8
Dubal, Stéphanie, and Roland Jouvent. "Time-on-task effect in trait anhedonia." European Psychiatry 19, no. 5 (August 2004): 285–91. http://dx.doi.org/10.1016/j.eurpsy.2004.04.007.
Full textAbstract:
AbstractThe capacity to sustain attention was explored in a sample of anhedonic subjects according to the Chapman physical anhedonia scale. Sustained attention was determined by studying task-induced changes over the duration of the Eriksen response competition task [Percept. Psychophys. 16 (1974) 143]. Anhedonic subjects had longer reaction times (RTs), but missed no more targets than control subjects. Anhedonic subject RTs got longer with time-on-task (TOT) and displayed greater intra-subject variability. These results confirm those of a previous study indicating that anhedonic subjects may have developed a more conservative response strategy [Psychophysiology 37 (2000) 711] and suggest that this strategy may result in a more rapid decrease in energetical resources. Moreover, the greater intra-subject variability demonstrates the importance of assessing performance over time and its relationship to the variability of responses in the cognitive performance of anhedonic subjects.
9
French, Claudia, and David Schuldberg. "Anhedonia and the Intentional Communication of Emotion." Perceptual and Motor Skills 79, no. 3 (December 1994): 1075–88. http://dx.doi.org/10.2466/pms.1994.79.3.1075.
Full textAbstract:
This study evaluated the accuracy and expressiveness of emotional communication by college students identified as anhedonic or control ( ns = 24), based on their scores on the Physical Anhedonia Scale, using an emotional communication task and self-report indices of emotional expressiveness and self-monitoring. As expected, the anhedonic group reported significantly less emotional expressiveness in real-life social situations. However, contrary to the hypotheses, they did not differ from controls on measures from a laboratory communication task or on self-monitoring.
10
Von Duering, F. "Anhedonic brain while attending sexual and emotional pictures." European Psychiatry 33, S1 (March 2016): S161. http://dx.doi.org/10.1016/j.eurpsy.2016.01.316.
Full textAbstract:
Anhedonia is defined as the inability to gain pleasure from normally pleasurable experiences and reduced sexual desire. Rees et al. (2007) showed that limbic and paralimbic areas are responsible for sexual arousal and that anhedonia is associated with frontolimbic inhibition. In major depression, reduced ventral striatum and increased ventral prefrontal cortex areas was associated with anhedonia(Gorwood, 2009). Walter et al. (2009) indicated that there is a deviation in the neuronal activation pattern of the pregenual anterior cingulate cortex in anhedonic depression which is related to a glutamergic deficit. Glutamate was suggested to play a relevant role in reward system (Birgner et al., 2005). ACC is a key involved in affective state and glutamate mediates ACC activation to sexual attraction(Wu et al., 2009). Thus, a glutamatergic deficit might be related to reduced hedonic effect specific to major depression. Using an attention modulation of emotional and sexual pictures, we investigate the role of anhedonia on the ventral and dorsal systems in healthy volunteers and patients with major depression. They undergo an expectancy task in a 7 T scanner and passively view sexual and emotional photographs and are asked to expect either high salient pictures or high erotic pictures. Half of these pictures are announced by an expectancy cue, whereas the other half are preceded by a fixation cross. Snaith-Hamilton-Pleasure-Scale and Hamilton Depression Rating Scale are employed to assess anhedonia and depressive symptom severity. Brain metabolites in the dorsal and pgACC are measured using MRS. We will show how anhedonia modulates the neural response to sexual arousal.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
11
Sipos-Lascu, Diana, Ștefan-Cristian Vesa, and Lăcrămioara Perju-Dumbravă. "Apathy and Anhedonia: Clinical and Neurophysiological Assessment of a Romanian Cohort." Brain Sciences 11, no. 6 (May 31, 2021): 729. http://dx.doi.org/10.3390/brainsci11060729.
Full textAbstract:
Background: Patients with Parkinson’s disease (PD) often have, besides the characteristic motor manifestations, a wide variety of non-motor symptoms. These include apathy and anhedonia, common issues in PD, which can be quantified with the help of evaluation scales recommended by the literature. There are sensory non-motor manifestations of PD, some of which are easy to detect through electrophysiological studies. Our aim was to investigate the possible association of apathy and anhedonia with the severity of the motor status in a sample of PD patients in Romania. We also examined the prevalence of latency changes in the P100 wave of visual evoked potentials (VEPs) and how they correlated with motor status, apathy, and anhedonia in PD patients. Methods: Thirty-four patients with PD participated in this study. All were assessed for motor status using the Unified Parkinson’s Disease Rating Scale (UPDRS) and were rated on the Hoehn and Yahr scales. The presence and severity of apathy and anhedonia were assessed using the Apathy Evaluation Scale (AES), the Dimensional Apathy Scale (DAS), the Lille Apathy Rating Scale (LARS), and the Snaith–Hamilton Pleasure Scale (SHAPS). The latency of the P100 wave of the VEP was measured in all the patients. Results: Apathy and anhedonia were common among the patients with PD (35% and 58.8%, respectively). The presence of apathy/anhedonia was correlated with the severity of motor symptoms, as assessed using the UPDRS scale (p < 0.001), and with the stage of the disease according to the Hoehn and Yahr scale (p < 0.001). A prolonged latency of the P100 wave of the VEP was observed among apathetic (p < 0.001)/anhedonic (p < 0.01) patients and those with increased disease severity (p < 0.001). Conclusion: Apathy and anhedonia are common in PD and may correlate with the severity of motor symptoms. There may be visual impairment in these patients, evidenced by a prolonged P100 latency, which correlates with the severity of disease. Significance: Scales for assessing apathy and anhedonia, as well as measuring VEP latency, could be useful in assessing the severity of disease.
12
Stefaniak, Aleksandra, Magdalena Berek-Zamorska, Claudia Zeidler, Sonja Ständer, and Jacek C. Szepietowski. "Chronic Itch Affects Patients’ Ability to Experience Pleasure: Anhedonia in Itchy Disorders." Acta Dermato-Venereologica 104 (August 23, 2024): adv35420. http://dx.doi.org/10.2340/actadv.v104.35420.
Full textAbstract:
Anhedonia, the reduced ability to experience pleasure, is a prevalent symptom in various psychiatric disorders, but has not been investigated in dermatological conditions, particularly those characterized by chronic itch. This study aimed to examine the prevalence and clinical correlates of anhedonia in patients with chronic itch. A cross-sectional study was conducted in 137 patients with chronic itch, classified according to the International Forum for the Study of Itch (IFSI) classification. Anhedonia was assessed using the Snaith–Hamilton Pleasure Scale (SHAPS) and Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS). Itch severity, quality of life, and psychological distress were assessed using the Visual Analogue Scale (VAS), Verbal Rating Scale (VRS), ItchyQoL, and Hospital Anxiety and Depression Scale (HADS), respectively. The mean SHAPS score was 1.0 ± 1.7 points, and the mean ACIPS total score was 76.9 ± 16.2 points. In the study sample, 13.1% of patients were identified as anhedonic, with a higher prevalence observed in those with severe and very severe itch. Anhedonia was significantly correlated with itch severity (R = 0.2, p=0.02 for 24 h VASmean and SHAPS; R = 0.2, p = 0.01 for 24 h VASmax and SHAPS), anxiety symptoms (R = 0.3, p < 0.001 for SHAPS and HADS-anxiety), depression symptoms (R = 0.4, p < 0.001 for SHAPS and HADS-depression), and impairment in quality of life (R = 0.2, p = 0.014 for SHAPS and ItchyQoL). Anhedonia is a significant and prevalent aspect of psychological distress in patients with chronic itch. Addressing this symptom may not only improve patients’ overall mental health but also enhance the effectiveness of treatments for chronic itch. Future research is needed to elucidate further the mechanisms underlying the relationship between anhedonia and chronic itch and to develop targeted interventions for this population.
13
Popov, M. M., S. A. Sorokin, and P. S. Kananovich. "Сognitive Functioning in Patients with the Phenomenon of Anhedonia in the Framework of Affective Pathology and Schizophrenia Spectrum Disorders." Psikhiatriya 21, no. 3 (June 19, 2023): 45–53. http://dx.doi.org/10.30629/2618-6667-2023-21-3-45-53.
Full textAbstract:
Background: anhedonia is a transdiagnostic psychopathological phenomenon, which is assessed as “core” for several diseases at once — first of all schizophrenic and affective spectrum disorders. The problem of clinical features differentiation and identification of anhedonia’s neurobiological mechanisms in the structure of the affective and schizophrenic spectrum disorders is still topical and far from being resolved.The aim of the study: to compare the relationship between the features of neurocognitive functioning and the manifestations of anhedonia among patients with disorders of the schizophrenic and affective spectra.Patients: the sample consisted of 40 patients including 17 patients with schizophrenic spectrum disorders (ICD-10 diagnosis codes F20.01, F20.02, F21.3, F21.4, F25.0, F25.1) and 23 patients with affective disorders (ICD-10 diagnosis code F33, F31).Methods: clinical, psychometric, experimental psychological and statistical.Results: patients with schizophrenia spectrum disorders show lower scores on pleasure anticipation ability and ability to experience pleasure in the social sphere. The affective spectrum group showed a correlation between anticipatory anhedonia and phonetic verbal fluency (r = –0.487; p < 0.01). There was also a correlation between immediate pleasure experience and errors in the Rey figure test (r = –0.349; p < 0.05). Social anhedonia in these patients was associated with phonetic verbal fluency productivity (r = –0.509; p < 0.01) and performance in visual fluency productivity (r = –0.473; p < 0.01). Patients with schizophrenia spectrum disorders had a correlation between anticipatory anhedonia and the Color-Word Interference Test (r = –0.329; p < 0.05) and the Rey Complex Figure Test (r = –0.307; p < 0.05). Consummatory anhedonia was correlated with verbal fluency test (r = –0.511; p < 0.01) and the Rey Complex Figure Test (r = –0.417; p < 0.01). Social anhedonia was correlated with Color-Word Interference Test (r = –0.656; p < 0.01), verbal fluency (r = –0.523; p < 0.01), and story description (r = –0.421; p < 0.01).Conclusion: manifestations of different parameters of anhedonia demonstrate the differences in schizophrenia and affective spectrum disorders. Patients with schizophrenia spectrum disorders have greater difficulties in anticipating pleasure and experiencing pleasure in the social sphere. The ability to anticipate pleasure may be associated with executive function, while the ability to experience pleasure immediately may be associated with memory function. Social anhedonia affects a wide range of cognitive functions.
14
Kaplan, Margaret. "Anhedonia." New England Review 42, no. 4 (2021): 104. http://dx.doi.org/10.1353/ner.2021.0108.
Full text
15
Slesinger, Warren. "Anhedonia." Iowa Review 22, no. 1 (January 1992): 119. http://dx.doi.org/10.17077/0021-065x.4110.
Full text
16
England, Eugene. "Anhedonia." Dialogue: A Journal of Mormon Thought 33, no. 3 (October 1, 2000): viii—ix. http://dx.doi.org/10.2307/45226707.
Full text
17
Corral-Frías, N. S., Y. S. Nikolova, L. J. Michalski, D. A. A. Baranger, A. R. Hariri, and R. Bogdan. "Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology." Psychological Medicine 45, no. 12 (April 8, 2015): 2605–17. http://dx.doi.org/10.1017/s0033291715000525.
Full textAbstract:
BackgroundEarly life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping.MethodBlood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia.ResultsAnalyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping.ConclusionsThese findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.
18
Song, Xin, and Iris Vilares. "Assessing the relationship between the human learned helplessness depression model and anhedonia." PLOS ONE 16, no. 3 (March 30, 2021): e0249056. http://dx.doi.org/10.1371/journal.pone.0249056.
Full textAbstract:
The learned helplessness (LH) model is one of the most commonly used acute stress models to explain depression and it has shown good face and predictive validity. However, despite being able to induce depressed-like behaviors and corresponding psychophysiological changes, there is little evidence showing that the LH paradigm can produce anhedonia, a core symptom seen in all forms of depression in humans. So far a couple of studies showed that rodents bred for helplessness develop anhedonic-like behaviors in response to stress; yet, to the best of our knowledge, no similar human research has tried to investigate the direct relationship between the LH model and anhedonia. In the present study, we use a modified version of the original LH task to experimentally and temporarily induce learned helplessness in college students and then examine if the human LH paradigm induces anhedonia. We aim to 1: address the ill-defined connection between the LH model and anhedonia, and 2: directly assess helplessness in humans as opposed to the majority of non-human animal subjects used in the helplessness literature. We believe that our study will fill an important gap in the learned helplessness model literature, and will advance our understanding of the relationship between depression and perceived control, as well as place limitations to what can and cannot be inferred from non-human animal data in this topic.
19
Mao, Ye, Yongkang Xu, and Xia Yuan. "Validity of chronic restraint stress for modeling anhedonic-like behavior in rodents: a systematic review and meta-analysis." Journal of International Medical Research 50, no. 2 (February 2022): 030006052210758. http://dx.doi.org/10.1177/03000605221075816.
Full textAbstract:
Background Chronic restraint stress (CRS) is widely used to recapitulate depression phenotypes in rodents but is frequently criticized for a perceived lack of efficacy. The aim of this study was to evaluate anhedonic-like behavior in the CRS model in rodents by performing a meta-analysis of studies that included sucrose preference tests. Methods This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. We comprehensively searched for eligible studies published before June 2021 in the PubMed, Embase, Medline, and Web of Science databases. We chose sucrose preference ratio as the indicative measure of anhedonia because it is a core symptom of depression in humans. Results Our pooled analysis included 34 articles with 57 studies and seven rodent species/strains and demonstrated decreased sucrose preference in the stress group compared with controls. The duration of CRS differentially affected the validity of anhedonic-like behavior in the models. Rats exhibited greater susceptibility to restraint stress than mice, demonstrating inter-species variability. Conclusions Our meta-analysis of studies that used the CRS paradigm to evaluate anhedonic-like behavior in rodents was focused on a core symptom of depression (anhedonia) as the main endpoint of the model and identified species-dependent susceptibility to restraint stress.
20
Su, Yun-Ai, and Tianmei Si. "Progress and challenges in research of the mechanisms of anhedonia in major depressive disorder." General Psychiatry 35, no. 1 (February 2022): e100724. http://dx.doi.org/10.1136/gpsych-2021-100724.
Full textAbstract:
There is an increasing heavy disease burden of major depressive disorder (MDD) globally. Both high diagnostic heterogeneity and complicated pathological mechanisms of MDD pose significant challenges. There is much evidence to support anhedonia as a core feature of MDD. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, anhedonia is further emphasised as a key item in the diagnosis of major depression with melancholic features. Anhedonia is a multifaceted symptom that includes deficits in various aspects of reward processing, such as anticipatory anhedonia, consummatory anhedonia, and decision-making anhedonia. Anhedonia is expected to become an important clinicopathological sign for predicting the treatment outcome of MDD and assisting clinical decision making. However, the precise neurobiological mechanisms of anhedonia in MDD are not clearly understood. In this paper, we reviewed (1) the current understanding of the link between anhedonia and MDD; (2) the biological basis of the pathological mechanism of anhedonia in MDD; and (3) challenges in research on the pathological mechanisms of anhedonia in MDD. A more in-depth understanding of anhedonia associated with MDD will improve the diagnosis, prediction, and treatment of patients with MDD in the future.
21
Siwek, Marcin, Adrian A. Chrobak, Zbigniew Sołtys, Dominika Dudek, and Anna J. Krupa. "Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample." Brain Sciences 14, no. 9 (August 31, 2024): 890. http://dx.doi.org/10.3390/brainsci14090890.
Full textAbstract:
Anhedonia constitutes a core symptom of major depressive disorder (MDD) mediating the ultimate goal of MDD treatment: functional remission. Anhedonia is also present in other clinical populations, including patients with chronic pain. Recent data links anhedonia to insulin resistance (IR). Some researchers have underlined a different dimension of anhedonia as a temperament/personality trait. The objective of this post-hoc analysis was to explore the links between anhedonia (main outcome) and (1) IR, (2) temperamental, personality, and schizotypy traits (exposures). The study population included patients with MDD, fibromyalgia, and healthy controls. Participants were split into groups: (1) insulin resistant (IR[+] n = 69, HOMA-IR ≥ 2.1) and (2) insulin sensitive (IR[−] n = 69, HOMA-IR < 2.1). Anhedonia was significantly higher in the IR[+] group than the IR[−] group. IR was a predictor of higher anhedonia levels. IR[+] vs. IR[−] participants showed higher levels of anxiety and lower levels of hyperthymic affective temperaments, as well as conscientiousness and emotional stability personality traits. Depressive, irritable, and anxious temperaments, cognitive disorganization, and introvertive anhedonia positively predicted anhedonia, while hyperthymic temperament, conscientiousness, extraversion, and emotional stability traits negatively predicted anhedonia. IR partially mediated the relationship between depressive temperament and anhedonia. In sum, IR, affective temperaments, and personality traits are predictors of anhedonia.
22
Holm, Sara E., Alexander Schmidt, and Christoph J. Ploner. "Musical Anhedonia." Zeitschrift für Neuropsychologie 31, no. 2 (June 1, 2020): 62–68. http://dx.doi.org/10.1024/1016-264x/a000292.
Full textAbstract:
Abstract. Some people, although they are perfectly healthy and happy, cannot enjoy music. These individuals have musical anhedonia, a condition which can be congenital or may occur after focal brain damage. To date, only a few cases of acquired musical anhedonia have been reported in the literature with lesions of the temporo-parietal cortex being particularly important. Even less literature exists on congenital musical anhedonia, in which impaired connectivity of temporal brain regions with the Nucleus accumbens is implicated. Nonetheless, there is no precise information on the prevalence, causes or exact localization of both congenital and acquired musical anhedonia. However, the frequent involvement of temporo-parietal brain regions in neurological disorders such as stroke suggest the possibility of a high prevalence of this disorder, which leads to a considerable reduction in the quality of life.
23
Perez-Rincón, Héctor. "La anhedonia." Revista Latinoamericana de Psicopatologia Fundamental 17, no. 4 (December 2014): 827–30. http://dx.doi.org/10.1590/1415-4714.2014v17n4p827.1.
Full text
24
Robbins, T. W. "Illuminating anhedonia." Science 351, no. 6268 (December 31, 2015): 24–25. http://dx.doi.org/10.1126/science.aad9698.
Full text
25
Treadway, Michael T., and David H. Zald. "Parsing Anhedonia." Current Directions in Psychological Science 22, no. 3 (June 2013): 244–49. http://dx.doi.org/10.1177/0963721412474460.
Full text
26
Melnikov, M. Ye. "The Social Anhedonia: (f)MRI Studies." Успехи физиологических наук 54, no. 1 (January 1, 2023): 70–90. http://dx.doi.org/10.31857/s030117982301006x.
Full textAbstract:
Abstract—Anhedonia and, particularly, social anhedonia is an important psychiatric symptom playing a crucial role in the development of depression and schizophrenia. Social anhedonia in healthy people is related to changes in structure, activation, and connectivity of different regions in the prefrontal, temporal, parieto-temporal, and basal areas. In patients with schizophrenia the core fMRI correlates of social anhedonia are located in the temporal lobe. Studies in social anhedonia in depressions and other mental disorders are insufficient for drawing conclusions on this topic. Unlike physical anhedonia, social anhedonia demonstrates no specific link with the Nucleus accumbens volume or activation.
27
Van Roekel, Eeske, and Albertine J. Oldehinkel. "How Personalized Behavioral Activation Interventions Improve the Behaviors of Individuals with Anhedonia." Journal of Emotion and Psychopathology 1, no. 1 (December 31, 2023): 345–55. http://dx.doi.org/10.55913/joep.v1i1.56.
Full textAbstract:
Background. Interventions for anhedonia often focus on re-engagement in pleasurable activities. We aimed to examine how anhedonic individuals changed their lifestyle behavior (i.e., physical activity, time outside, worrying, and social activity) after a personalized lifestyle advice session, and how these changes in behavior where associated with improvement. Methods. Participants were 69 young adults with persistent anhedonia, who filled out 3 assessments per day about lifestyle behaviors and affect for 3 months. After an observation month, participants received personalized lifestyle advice. Results. Results showed that only changes in social interaction, physical activity, and worrying were associated with improvement in positive affect (PA) and pleasure. Further exploration of the reciprocal associations between behaviors and PA and pleasure showed that physical activity and worrying were reciprocally associated with PA or pleasure, indicating a positive feedback loop. Conclusions. Results indicate that momentary assessments are an effective tool to detect mechanisms of change in interventions.
28
Benson, Peter, Nicholas Kathios, and Psyche Loui. "Predictive coding in musical anhedonia: A study of groove." PLOS ONE 19, no. 4 (April 23, 2024): e0301478. http://dx.doi.org/10.1371/journal.pone.0301478.
Full textAbstract:
Groove, or the pleasurable urge to move to music, offers unique insight into the relationship between emotion and action. The predictive coding of music model posits that groove is linked to predictions of music formed over time, with stimuli of moderate complexity rated as most pleasurable and likely to engender movement. At the same time, listeners vary in the pleasure they derive from music listening: individuals with musical anhedonia report reduced pleasure during music listening despite no impairments in music perception and no general anhedonia. Little is known about musical anhedonics’ subjective experience of groove. Here we examined the relationship between groove and music reward sensitivity. Participants (n = 287) heard drum-breaks that varied in perceived complexity, and rated each for pleasure and wanting to move. Musical anhedonics (n = 13) had significantly lower ratings compared to controls (n = 13) matched on music perception abilities and general anhedonia. However, both groups demonstrated the classic inverted-U relationship between ratings of pleasure & move and stimulus complexity, with ratings peaking for intermediately complex stimuli. Across our entire sample, pleasure ratings were most strongly related with music reward sensitivity for highly complex stimuli (i.e., there was an interaction between music reward sensitivity and stimulus complexity). Finally, the sensorimotor subscale of music reward was uniquely associated with move, but not pleasure, ratings above and beyond the five other dimensions of musical reward. Results highlight the multidimensional nature of reward sensitivity and suggest that pleasure and wanting to move are driven by overlapping but separable mechanisms.
29
Hughes, John R., Elias M. Klemperer, and Catherine Peasley-Miklus. "Possible New Symptoms of Tobacco Withdrawal II: Anhedonia—A Systematic Review." Nicotine & Tobacco Research 22, no. 1 (August 23, 2018): 11–17. http://dx.doi.org/10.1093/ntr/nty171.
Full textAbstract:
Abstract Introduction When animals undergo nicotine deprivation, rewards become less rewarding (ie, anhedonia occurs). We searched for tests of whether anhedonia occurs in abstinent smokers. Methods The major inclusion criterion was a within-participants comparison of behavioral measures of reward sensitivity or self-reported anhedonia during smoking versus during abstinence among daily smokers. A computerized search of PubMed, PsychInfo, and Cochrane databases and other methods located 13 studies. All but one were laboratory studies. Results The number of studies and participants were small and the results mixed. In terms of anticipatory anhedonia (ie, wanting a reward), abstinence appeared to decrease willingness to work for immediately available rewards, but did not appear to influence how much adding rewards to a task increased responding. Abstinence also appeared to produce small increases in self-reported anticipatory anhedonia. In terms of consummatory anhedonia (ie, liking a reward), self-report measures found anhedonia decreased pleasure from rewards in some but not all tests. In terms of learning (ie, learning to choose a more frequent reward), abstinence did not reliably decrease allocating responding to high versus low frequency reward options. Conclusions Although results were mixed, abstinence appears to increase anticipatory anhedonia. It is unclear if abstinence increases consummatory or reward learning-based anhedonia. Further studies of anhedonia in clinical settings are needed (1) to estimate the reliability and clinical significance of anhedonia as a symptom of tobacco withdrawal, (2) to assess if effects represent withdrawal versus offset processes, and (3) to assess if anhedonia interferes with the ability to stop smoking. Implications Anticipatory anhedonia appears to be a symptom of tobacco withdrawal and should be added to tobacco withdrawal checklists and diagnostic criteria. Further study of consummatory and learning-based anhedonia is warranted.
30
Strekalova, Tatyana, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, and Raymond Cespuglio. "Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice." International Journal of Molecular Sciences 23, no. 4 (February 13, 2022): 2061. http://dx.doi.org/10.3390/ijms23042061.
Full textAbstract:
The phenomenon of individual variability in susceptibility/resilience to stress and depression, in which the hippocampus plays a pivotal role, is attracting increasing attention. We investigated the potential role of hippocampal cyclooxygenase-2 (COX-2), which regulates plasticity, neuroimmune function, and stress responses that are all linked to this risk dichotomy. We used a four-week-long chronic mild stress (CMS) paradigm, in which mice could be stratified according to their susceptibility/resilience to anhedonia, a key feature of depression, to investigate hippocampal expression of COX-2, a marker of microglial activation Iba-1, and the proliferation marker Ki67. Rat exposure, social defeat, restraints, and tail suspension were used as stressors. We compared the effects of treatment with either the selective COX-2 inhibitor celecoxib (30 mg/kg/day) or citalopram (15 mg/kg/day). For the celecoxib and vehicle-treated mice, the Porsolt test was used. Anhedonic (susceptible) but not non-anhedonic (resilient) animals exhibited elevated COX-2 mRNA levels, increased numbers of COX-2 and Iba-1-positive cells in the dentate gyrus and the CA1 area, and decreased numbers of Ki67-positive cells in the subgranular zone of the hippocampus. Drug treatment decreased the percentage of anhedonic mice, normalized swimming activity, reduced behavioral despair, and improved conditioned fear memory. Hippocampal over-expression of COX-2 is associated with susceptibility to stress-induced anhedonia, and its pharmacological inhibition with celecoxib has antidepressant effects that are similar in size to those of citalopram.
31
Darquennes, Gil, Benjamin Wacquier, Gwenolé Loas, and Matthieu Hein. "Suicidal Ideations in Major Depressed Subjects: Role of the Temporal Dynamics of Anhedonia." Brain Sciences 13, no. 7 (July 13, 2023): 1065. http://dx.doi.org/10.3390/brainsci13071065.
Full textAbstract:
Given the limited data available in the literature, the aim of this study was to investigate the potential role played by the temporal dynamics of anhedonia (lifelong anhedonia and recent changes in anhedonia) in the occurrence of suicidal ideations in major depressed subjects. The clinical data of 285 major depressed subjects recruited from the database of the Erasme Hospital Sleep Laboratory were analyzed. A score on item nine of the Beck Depression Inventory (BDI-II) ≥1 and/or an identification during the systematic psychiatric assessment were used to determine the presence of suicidal ideations. The association between anhedonia complaints (lifelong anhedonia and recent change in anhedonia) and suicidal ideations in major depressed subjects was assessed by logistic regression analyzes. The prevalence of suicidal ideations was 39.3% in our sample of major depressed subjects. After adjusting for the main confounding factors, multivariate logistic regression analysis demonstrated that unlike lifelong anhedonia, only recent changes in anhedonia were a risk factor for suicidal ideations in major depressed subjects. Given this potential involvement of the recent change in anhedonia in the occurrence of suicidal ideations in major depressed subjects, it seems essential to better identify and adequately manage this specific form of anhedonia in order to open new perspectives for the prevention of suicide in this particular sub-population.
32
Young, Katherine S., Susan Y. Bookheimer, Robin Nusslock, Richard E. Zinbarg, Katherine S. F. Damme, Iris Ka-Yi Chat, Nicholas J. Kelley, et al. "Dysregulation of threat neurociruitry during fear extinction: the role of anhedonia." Neuropsychopharmacology 46, no. 9 (April 8, 2021): 1650–57. http://dx.doi.org/10.1038/s41386-021-01003-8.
Full textAbstract:
AbstractDimensional models of anxiety and depression highlight common and distinct symptom clusters that are thought to reflect disruptions in underlying functional processes. The current study investigated how functioning of threat neurocircuitry relates to symptom dimensions of anxiety and depression. Participants were aged 18–19 years (n = 229, 158 female) and were selected to ensure a range of scores on symptom measures. Symptom dimensions of “General Distress” (common to anxiety disorders and depression), “Fears” (more specific to anxiety disorders), and “Anhedonia-apprehension” (more specific to depression) were evaluated. Participants underwent functional magnetic resonance imaging during a Pavlovian fear conditioning paradigm. Multilevel modeling analyses estimated relationships between symptom dimensions and activation in threat neural circuitry. Exploratory whole brain analyses were also conducted. Threat-related neural activity was not associated with General Distress or Fears. Anhedonia-apprehension was associated with activation of bilateral amygdala, anterior insula and dACC during late extinction. We found no evidence to support an association between symptom dimensions of General Distress or Fears with threat circuitry activation in a large sample of young adults. We did, however, find that the symptom dimension of Anhedonia-apprehension was significantly associated with threat-related neural activation during fear extinction. This effect requires replication in future work but may reflect anhedonic impairments in learning when contingencies are altered, possibly linked to the rewarding relief of an unexpectedly absent threat.
33
Takigawa, Morikuni, Hiroshi Maeda, Kenichi Ueyama, Hidefumi Tominaga, and Kei Matsumoto. "A dual approach to self-stimulation and locomotor trace affected by chronic methamphetamine treatment for an animal model of schizophrenia." Canadian Journal of Physiology and Pharmacology 71, no. 5-6 (May 1, 1993): 321–25. http://dx.doi.org/10.1139/y93-050.
Full textAbstract:
The effect of long-term methamphetamine (MAP) treatment on intracranial self-stimulation of the lateral hypotholamus and locomotor traces was assessed. An attempt was made to provide a useful animal model for understanding anhedonia, stereotypy, and reoccurrence of liability, which are analogous to symptoms of schizophrenia. The frequency of intracranial self-stimulation (ICSS) as used as a measure of the animals' "hedonic–anhedonic" state. Following long-term MAP treatment (3 mg/kg), rats gradually showed stereotyped behavior, and became inactive and unresponsive to ICSS. These behavioral changes and decreased ICSS lasted several weeks after cessation of chronic MAP treatment and seemed to suggest post-MAP chronic psychosis and (or) anhedonia, two of the negative symptoms of schizophrenia. The traces of rat behavior affected by chronic MAP treatment were classified into three types, peripheral, mixed, and fixed, occurring in a dose-dependent manner. Reverse tolerance, similar to the reoccurrence of schizophrenic symptoms, was observed as a fixed stereotypy associated with loss of ICSS. These abnormal phenomena were suppressed by pretreatment with haloperidol. In the present study, the combination of ICSS and locomotor trace affected by chronic MAP treatment was proposed as an animal model of schizophrenia and as a useful technique for gauging the effect of neuroleptics.Key words: self-stimulation, anhedonia, stereotypy, reverse tolerance, animal disease model, schizophrenia, methamphetamine.
34
McIntyre, Roger S., Pierre Michel Llorca, Lauren C. Aronin, Jun Yu, Huy-Binh Nguyen, and Ken Kramer. "Impact of Cariprazine on Anhedonia Symptoms in Patients with Bipolar I Depression: Pooled Analysis of 3 Pivotal Clinical Trials." CNS Spectrums 29, no. 5 (October 2024): 488. https://doi.org/10.1017/s1092852924001421.
Full textAbstract:
PurposeAnhedonia characterizes major depressive episodes in bipolar depression and is associated with more severe illness/poor prognosis. These post hoc analyses assess effect of cariprazine 1.5 and 3 mg/d on anhedonia symptoms in patients with bipolar I depression.MethodsData were pooled from 3 randomized, double-blind, placebo-controlled bipolar I depression trials in cariprazine. Cariprazine 1.5 and 3 mg/d versus placebo were evaluated in patient subgroups stratified by median baseline MADRS anhedonia score (higher anhedonia=score ≥19; lower anhedonia=score <19). Outcomes included mean change from baseline to week 6 in MADRS total and anhedonia factor score (sum of apparent sadness, reported sadness, concentration, lassitude, and inability to feel items). The proportion of patients with week 6 anhedonia factor response (≥50% improvement from baseline) was also determined. Changes from baseline were analyzed using a mixed-effect model for repeated measures.ResultsThere were 760 patients in the higher anhedonia subgroup (placebo=249, cariprazine: 1.5 mg/d=261; 3 mg/d=250) and 623 patients in the lower anhedonia subgroup (placebo=211, cariprazine: 1.5 mg/d=200; 3 mg/d=212). Mean baseline MADRS total score was higher in the higher anhedonia subgroup (total=33.6) than in the lower anhedonia subgroup (total=27.6). Change from baseline to week 6 in MADRS total score was greater for both cariprazine doses versus placebo in the higher anhedonia subgroup (least squares mean difference [LSMD] and 95% confidence interval [CI]: 1.5 mg/d=-3.01 [-4.84, -1.19], P=.0012; 3 mg/d: -3.26 [-5.12, -1.40], P=.0006); in the lower anhedonia subgroup, cariprazine 1.5 mg/d was statistically significant versus placebo (-2.61 [-4.28, -0.93], P=.0024). In the higher anhedonia subgroup at week 6, change from baseline in anhedonia factor score was significant versus placebo for both cariprazine doses (1.5 mg/d=-1.97 [-3.13, -0.81], P=.0009; 3 mg/d=-2.07 [-3.26, -0.89], P=.0006); in the lower subgroup, the difference was significant versus placebo for cariprazine 1.5 mg/d (-1.70 [-2.77, -0.62], P=.0021). After adjusting for changes in other depressive symptoms, LSMDs versus placebo in the anhedonia factor score remained significant for cariprazine 1.5 mg/d (-1.21 [-2.05, -0.36], P=.0052) and 3 mg/d (-1.00 [-1.86, -0.14], P=.0233) in the higher anhedonia subgroup, and for 1.5 mg/d (-1.06 [-1.92, -0.19], P=.0164) in the lower subgroup. In the higher anhedonia subgroup, rates of anhedonia factor response were greater versus placebo (31.7%) for cariprazine 1.5 mg/d (44.8%, P=.0028) and 3 mg/d (45.6%, P=.0019); in the lower subgroup, response rates were 39.3% for placebo, 48.0% for 1.5 mg/d, and 46.7% for 3 mg/d. Adverse events in ≥5% cariprazine and twice placebo were nausea, akathisia, restlessness, and EPS.ImportanceThose with bipolar depression and anhedonia cariprazine demonstrated a potent antidepressant and antianhedonic effect in higher/lower anhedonia subgroups.FundingAbbVieThis data was previously presented at the European College of Neuropsychopharmacology (ECNP) Congress; Barcelona, Spain; October 7 – 10, 2023.
35
Petit, G., G. Deschietere, G. Loas, O. Luminet, and P. de Timary. "Link Between Anhedonia and Depression During Early Alcohol Abstinence: Gender Matters." Alcohol and Alcoholism 55, no. 1 (December 11, 2019): 71–77. http://dx.doi.org/10.1093/alcalc/agz090.
Full textAbstract:
Abstract Aims The aim of the present study was to evaluate the relation between anhedonia and depression in alcohol use disorders (AUD) during detoxification: Is trait anhedonia measured at the beginning of detoxification predictive of depressive symptoms observed at the end? Does state anhedonia recover during detoxification as depression does? Gender differences that have been previously observed for depression in AUD were also explored. Methods 81 AUD inpatients were tested at T1 (day 1) and T2 (day 14–18) of withdrawal with the trait Physical Anhedonia Scale, the state anhedonia Snaith–Hamilton Pleasure Scale, the Beck depression inventory and the Spielberger State Anxiety Inventory and compared to 34 control participants, matched for age and gender. Results AUD patients scored significantly higher than controls on depression, anxiety and state and trait anhedonia when they just entered the detoxification unit. Depression, anxiety and state anhedonia decreased between T1 and T2 in AUD patients. In women, state anhedonia at T1 was predictive of depressive symptoms at T2 over and above anxiety and depression at T1. Conclusion In AUD, state anhedonia recovers during detoxification, concurrently to other affective-related symptoms. However, in women, trait anhedonia predicts the level of depression at the end of detoxification, above and beyond anxiety. This finding stresses the importance of addressing anhedonia in the treatment of AUD and emphasizes the need for targeted interventions within clinical settings in this gender. Clinical consequences are discussed.
36
Garland, Eric L., Martin Trøstheim, Marie Eikemo, Gernot Ernst, and Siri Leknes. "Anhedonia in chronic pain and prescription opioid misuse." Psychological Medicine 50, no. 12 (August 19, 2019): 1977–88. http://dx.doi.org/10.1017/s0033291719002010.
Full textAbstract:
AbstractBackgroundBoth acute and chronic pain can disrupt reward processing. Moreover, prolonged prescription opioid use and depressed mood are common in chronic pain samples. Despite the prevalence of these risk factors for anhedonia, little is known about anhedonia in chronic pain populations.MethodsWe conducted a large-scale, systematic study of anhedonia in chronic pain, focusing on its relationship with opioid use/misuse, pain severity, and depression. Chronic pain patients across four distinct samples (N = 488) completed the Snaith–Hamilton Pleasure Scale (SHAPS), measures of opioid use, pain severity and depression, as well as the Current Opioid Misuse Measure (COMM). We used a meta-analytic approach to determine reference levels of anhedonia in healthy samples spanning a variety of countries and diverse age groups, extracting SHAPS scores from 58 published studies totaling 2664 psychiatrically healthy participants.ResultsCompared to healthy samples, chronic pain patients showed higher levels of anhedonia, with ~25% of patients scoring above the standard anhedonia cut-off. This difference was not primarily driven by depression levels, which explained less than 25% of variance in anhedonia scores. Neither opioid use duration, dose, nor pain severity alone was significantly associated with anhedonia. Yet, there was a clear effect of opioid misuse, with opioid misusers (COMM ⩾13) reporting greater anhedonia than non-misusers. Opioid misuse remained a significant predictor of anhedonia even after controlling for pain severity, depression and opioid dose.ConclusionsStudy results suggest that both chronic pain and opioid misuse contribute to anhedonia, which may, in turn, drive further pain and misuse.
37
Han, Jing, Liu-hong Zhang, Cai-yi Zhang, Liuna Bi, Lin-lin Wang, and Yan-xiu Cai. "Adolescent’s anhedonia and association with childhood trauma among Chinese adolescents: a cross-sectional study." BMJ Open 13, no. 10 (October 2023): e071521. http://dx.doi.org/10.1136/bmjopen-2022-071521.
Full textAbstract:
ObjectivesTo estimate the level of anhedonia among adolescents and explore the association between anhedonia and childhood trauma (CT).DesignA stratified random cluster sample of adolescents participated in a survey, which included three questionnaires: Snaith-Pamilton Pleasure Scale, Childhood Trauma Questionnaire and Patient Health Questionnaire-9.SettingThe study was conducted in 60 classes in 10 primary, middle and high schools in five economically developed cities along the Southeast Coast of China from April to October 2022.ParticipantsOne thousand seven hundred and forty-five adolescents with ages ranging from 9 to 18 years participated in the study.Primary and secondary outcomesThe primary outcome was the level of anhedonia, CT and depression among adolescents. The association between anhedonia and CT was determined.ResultsThe mean scores of anhedonia, CT and depression were 24.88 (6.18), 36.75 (8.87) and 4.46 (5.36), respectively. Anhedonia scores of boys (24.24±6.12) and girls (25.62±6.16) were different (t=−4.69, p<0.01). After controlling for sex, age, the presence of siblings and depression, CT was associated with adolescent anhedonia. Emotional abuse (β=0.14), emotional neglect (β=0.15) and physical neglect (β=0.10) positively predicted adolescent anhedonia (p<0.01), whereas physical abuse negatively predicted adolescent anhedonia (β=−0.07, p<0.01). Sex had a moderating effect on the relationship between adolescent anhedonia and emotional neglect during childhood, and the negative effect of emotional neglect on adolescent anhedonia in girls was greater than in boys.ConclusionsCT, including emotional abuse, physical abuse, emotional neglect, and physical neglect, was an independent predictor of adolescents’ ability to experience pleasure in daily life. Therefore, awareness of CT should be promoted. Emotional neglect had a more severe effect on anhedonia among girls than among boys, suggesting that emotional neglect should be paid much attention among girls
38
Strekalova, Tatyana, Evgeniy Svirin, Anna Gorlova, Elizaveta Sheveleva, Alisa Burova, Adel Khairetdinova, Kseniia Sitdikova, et al. "Resilience and Vulnerability to Stress-Induced Anhedonia: Unveiling Brain Gene Expression and Mitochondrial Dynamics in a Mouse Chronic Stress Depression Model." Biomolecules 13, no. 12 (December 12, 2023): 1782. http://dx.doi.org/10.3390/biom13121782.
Full textAbstract:
The role of altered brain mitochondrial regulation in psychiatric pathologies, including Major Depressive Disorder (MDD), has attracted increasing attention. Aberrant mitochondrial functions were suggested to underlie distinct inter-individual vulnerability to stress-related MDD syndrome. In this context, insulin receptor sensitizers (IRSs) that regulate brain metabolism have become a focus of recent research, as their use in pre-clinical studies can help to elucidate the role of mitochondrial dynamics in this disorder and contribute to the development of new antidepressant treatment. Here, following 2-week chronic mild stress (CMS) using predation, social defeat, and restraint, MDD-related behaviour and brain molecular markers have been investigated along with the hippocampus-dependent performance and emotionality in mice that received the IRS dicholine succinate (DS). In a sucrose test, mice were studied for the key feature of MDD, a decreased sensitivity to reward, called anhedonia. Based on this test, animals were assigned to anhedonic and resilient-to-stress-induced-anhedonia groups, using a previously established criterion of a decrease in sucrose preference below 65%. Such assignment was based on the fact that none of control, non-stressed animals displayed sucrose preference that would be smaller than this value. DS-treated stressed mice displayed ameliorated behaviours in a battery of assays: sucrose preference, coat state, the Y-maze, the marble test, tail suspension, and nest building. CMS-vulnerable mice exhibited overexpression of the inflammatory markers Il-1β, tnf, and Cox-1, as well as 5-htt and 5-ht2a-R, in various brain regions. The alterations in hippocampal gene expression were the closest to clinical findings and were studied further. DS-treated, stressed mice showed normalised hippocampal expression of the plasticity markers Camk4, Camk2, Pka, Adcy1, Creb-ar, Nmda-2r-ar, and Nmda-2r-s. DS-treated and non-treated stressed mice who were resilient or vulnerable to anhedonia were compared for hippocampal mitochondrial pathway regulation using Illumina profiling. Resilient mice revealed overexpression of the mitochondrial complexes NADH dehydrogenase, succinate dehydrogenase, cytochrome bc1, cytochrome c oxidase, F-type and V-type ATPases, and inorganic pyrophosphatase, which were decreased in anhedonic mice. DS partially normalised the expression of both ATPases. We conclude that hippocampal reduction in ATP synthesis is associated with anhedonia and pro-inflammatory brain changes that are ameliorated by DS.
39
Langvik, Eva, and Sigrun Borgen Austad. "Psychometric Properties of the Snaith–Hamilton Pleasure Scale and a Facet-Level Analysis of the Relationship Between Anhedonia and Extraversion in a Nonclinical Sample." Psychological Reports 122, no. 1 (February 28, 2018): 360–75. http://dx.doi.org/10.1177/0033294118756336.
Full textAbstract:
The aim of this study is to investigate the psychometric properties of the Snaith–Hamilton Pleasure Scale (SHAPS) and look at facets of extraversion as predictors of anhedonia. SHAPS is hypothesized to be multidimensional, stable over time in a nonclinical sample, and related to extraversion on both dimension and facet level. Data collection was conducted at baseline ( N = 362) and at a 10-week follow-up ( N = 94). The structural properties of SHAPS were analyzed using principal component analysis and confirmatory factor analysis. Multiple regression explored facets of extraversion as predictors of anhedonia. The results show that SHAPS is stable across time ( r = .71, p < .001), with high internal consistency (α = .89). In the principal component analysis, a two-factor model emerged (Social and Physical anhedonia). The confirmatory factor analysis indicated that the two-factor model consisting of Physical anhedonia (α = .81) and Social anhedonia (α = .87) had a better fit than the one-factor model. Higher scores on Gregariousness and Positive emotions at baseline predicted higher scores on the SHAPS total and Social and Physical anhedonia ( p < .05). Lower scores on Assertiveness predicted higher scores on Social anhedonia ( p < .05). These results support the view of anhedonia as a multidimensional concept that should be regarded as a trait, rather than a state or mere bypassing symptom. The relationship between anhedonia and extroversion is best understood by applying a multidimensional approach to anhedonia and by focusing on the facet level of extroversion.
40
Frey, Anna-Lena, Mehmet Siyabend Kaya, Irina Adeniyi, and Ciara McCabe. "Anhedonia in Relation to Reward and Effort Learning in Young People with Depression Symptoms." Brain Sciences 13, no. 2 (February 17, 2023): 341. http://dx.doi.org/10.3390/brainsci13020341.
Full textAbstract:
Anhedonia, a central depression symptom, is associated with impairments in reward processing. However, it is not well understood which sub-components of reward processing (anticipation, motivation, consummation, and learning) are impaired in association with anhedonia in depression. In particular, it is unclear how learning about different rewards and the effort needed to obtain them might be associated with anhedonia and depression symptoms. Therefore, we examined learning in young people (N = 132, mean age 20, range 17–25 yrs.) with a range of depression and anhedonia symptoms using a probabilistic instrumental learning task. The task required participants to learn which options to choose to maximize their reward outcomes across three conditions (chocolate taste, puppy images, or money) and to minimize the physical effort required to obtain the rewards. Additionally, we collected questionnaire measures of anticipatory and consummatory anhedonia, as well as subjective reports of “liking”, “wanting” and “willingness to exert effort” for the rewards used in the task. We found that as anticipatory anhedonia increased, subjective liking and wanting of rewards decreased. Moreover, higher anticipatory anhedonia was significantly associated with lower reward learning accuracy, and participants demonstrated significantly higher reward learning than effort learning accuracy. To our knowledge, this is the first study observing an association of anhedonia with reward liking, wanting, and learning when reward and effort learning are measured simultaneously. Our findings suggest an impaired ability to learn from rewarding outcomes could contribute to anhedonia in young people. Future longitudinal research is needed to confirm this and reveal the specific aspects of reward learning that predict anhedonia. These aspects could then be targeted by novel anhedonia interventions.
41
Berenbaum, Howard, Rebecca Snowhite, and Thomas F. Oltmanns. "Anhedonia and emotional responses to affect evoking stimuli." Psychological Medicine 17, no. 3 (August 1987): 677–84. http://dx.doi.org/10.1017/s0033291700025915.
Full textAbstract:
SynopsisThe purpose of the present study was to determine whether individuals with unusually high scores on the Scale for Physical Anhedonia (Chapmanet al.1976) would differ from average scorers in their emotional responses to affect-evoking stimuli. Ten male and ten female anhedonics, well as ten male and ten female control subjects, were each shown brief filmclips that were expected to elicit emotional responses. The subjects' facial expressions were videotaped while they watched the filmclips, and they also completed adjective checklists describing how they felt while watching them. The anhedonics and nonanhedonics did not differ in their self-reports of emotional experience, nor did they differ in their facial expressions of emotion while viewing the filmclips. Compared to men, women reported experiencing more emotion, and their facial expressions also indicated greater responsiveness.
42
Grippo, Angela J., Claudia M. Santos, Ralph F. Johnson, Terry G. Beltz, James B. Martins, Robert B. Felder, and Alan Kim Johnson. "Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 2 (February 2004): H619—H626. http://dx.doi.org/10.1152/ajpheart.00450.2003.
Full textAbstract:
Depression is an important public health problem and is considered to be an independent risk factor for coronary artery disease. The pathophysiological mechanisms that link depression with adverse cardiovascular events (e.g., myocardial ischemia, myocardial infarction, and sudden death) are not well established. It is possible that an increased susceptibility to life-threatening cardiac arrhythmias in depressed patients influences the risk of morbidity and mortality in coronary artery disease. This idea was tested with the use of an experimental model of depression that was developed to induce anhedonia, the reduced responsiveness to pleasurable stimuli observed in human depressed patients. Rats exposed to 4 wk of chronic mild stress (e.g., paired housing, strobe light, and white noise) displayed anhedonia, which was operationally defined by the reduced intake of a palatable sucrose solution relative to an established baseline and to control animals. Furthermore, compared with control rats, the anhedonic rats showed increased basal heart rate and decreased heart rate variability. In response to an intravenously infused chemical challenge, aconitine, anhedonic rats exhibited an increased vulnerability to ventricular arrhythmias, as indicated by a reduced threshold for premature ventricular complexes, salvos, and ventricular tachycardia. These findings suggest that the presence of depressive symptoms is associated with a lower threshold for ventricular arrhythmias, which may contribute to the increased risk for adverse cardiovascular events in patients with depression.
43
McIntyre, Roger S., Vladimir Maletic, Prakash Masand, Andrea C. Wilson, Jun Yu, Kenneth Kramer, Julie L. Adams, and Majid Kerolous. "Effect of Adjunctive Cariprazine on Symptoms of Anhedonia in Patients with Major Depressive Disorder." CNS Spectrums 29, no. 5 (October 2024): 498. https://doi.org/10.1017/s1092852924001597.
Full textAbstract:
PurposeAnhedonia, a multidimensional domain including the reduced ability to experience pleasure, is a core diagnostic symptom of major depressive disorder (MDD) and a common residual symptom. In patients with MDD, anhedonia has been associated with poor treatment outcomes, suicide and reduced functioning and quality of life. This post-hoc analysis of data from a phase 3 trial (NCT03738215) evaluated the efficacy of adjunctive cariprazine (CAR) treatment on anhedonia symptoms in patients with MDD.MethodsPatients with MDD and inadequate response to ongoing antidepressant therapy (ADT) were randomized to CAR 1.5 mg/d + ADT, CAR 3 mg/d + ADT, or placebo + ADT for 6 weeks of double-blind treatment. Post hoc analyses evaluated the change from baseline to Week 6 in Montgomery–Åsberg Depression Rating Scale (MADRS) total score, MADRS anhedonia subscale score (items: 1 [apparent sadness], 2 [reported sadness], 6 [concentration difficulties], 7 [lassitude], and 8 [inability to feel]), and MADRS anhedonia item 8 in the overall modified intent-to-treat (mITT) population and in subgroups of patients with baseline MADRS anhedonia item 8 score of ≥4 or baseline anhedonia subscale score of ≥18. Least square (LS) mean change from baseline to Week 6 was analyzed using a mixed-effects model for repeated measures.ResultsThere were 751 patients in the mITT population (CAR + ADT: 1.5 mg/d=250, 3 mg/d=252; placebo + ADT=249). At baseline, 508 (67.6%) patients had MADRS anhedonia item 8 scores ≥4, and 584 (77.8%) had MADRS anhedonia subscale scores ≥18. In the overall mITT population, LS mean change from baseline to Week 6 in anhedonia subscale score was significantly greater for CAR 1.5 mg/d + ADT (-8.4) and CAR 3 mg/d + ADT (-7.9) than for placebo + ADT (-6.8; both P<.05). The LS mean change from baseline in MADRS individual item 8 was also significantly greater for CAR 1.5 mg/d + ADT (-1.7) vs placebo + ADT (-1.3; P=.0085). In both subgroups of patients with baseline anhedonia, CAR 1.5 mg/d + ADT was associated with significantly greater reduction in MADRS total score, MADRS anhedonia subscale score, and MADRS item 8 score compared with placebo + ADT (all P<.05). In the CAR 3 mg/d + ADT group, significantly greater reductions vs placebo + ADT were observed for MADRS total score and MADRS anhedonia subscale score in the subgroup of patients with baseline anhedonia subscale scores ≥18 (both P<.05).ImportanceAdjunctive treatment with CAR was associated with a reduction in symptoms of anhedonia relative to adjunctive placebo in patients with MDD and inadequate response to ADT alone. In subgroups of patients with moderate-to-severe anhedonia at baseline, CAR + ADT demonstrated greater improvements than placebo + ADT in overall depressive symptoms and symptoms of anhedonia. These results suggest that adjunctive CAR treatment may be effective for improving symptoms of anhedonia in patients with MDD who have symptoms of anhedonia.FundingAbbVie
44
Martínez-Molina, Noelia, Ernest Mas-Herrero, Antoni Rodríguez-Fornells, Robert J. Zatorre, and Josep Marco-Pallarés. "Neural correlates of specific musical anhedonia." Proceedings of the National Academy of Sciences 113, no. 46 (October 31, 2016): E7337—E7345. http://dx.doi.org/10.1073/pnas.1611211113.
Full textAbstract:
Although music is ubiquitous in human societies, there are some people for whom music holds no reward value despite normal perceptual ability and preserved reward-related responses in other domains. The study of these individuals with specific musical anhedonia may be crucial to understand better the neural correlates underlying musical reward. Previous neuroimaging studies have shown that musically induced pleasure may arise from the interaction between auditory cortical networks and mesolimbic reward networks. If such interaction is critical for music-induced pleasure to emerge, then those individuals who do not experience it should show alterations in the cortical-mesolimbic response. In the current study, we addressed this question using fMRI in three groups of 15 participants, each with different sensitivity to music reward. We demonstrate that the music anhedonic participants showed selective reduction of activity for music in the nucleus accumbens (NAcc), but normal activation levels for a monetary gambling task. Furthermore, this group also exhibited decreased functional connectivity between the right auditory cortex and ventral striatum (including the NAcc). In contrast, individuals with greater than average response to music showed enhanced connectivity between these structures. Thus, our results suggest that specific musical anhedonia may be associated with a reduction in the interplay between the auditory cortex and the subcortical reward network, indicating a pivotal role of this interaction for the enjoyment of music.
45
Lubman, Dan I., Joshua BB Garfield, Stella M. Gwini, Ali Cheetham, Sue M. Cotton, Murat Yücel, and Nicholas B. Allen. "Dynamic associations between opioid use and anhedonia: A longitudinal study in opioid dependence." Journal of Psychopharmacology 32, no. 9 (August 21, 2018): 957–64. http://dx.doi.org/10.1177/0269881118791741.
Full textAbstract:
Background: Anhedonia is a commonly reported symptom among substance-dependent populations that appears to diminish with sustained abstinence. However, previous research has not determined whether anhedonia is dynamically linked to changing patterns of drug use, nor whether it predicts subsequent drug use. Aims: We aimed to test whether changes in illicit opioid use would predict changes in anhedonia, and whether increases in anhedonia would predict further opioid use. Methods: We conducted a longitudinal, observational study, with a convenience sample of 121 participants with current or past-year Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition Text Revision (DSM-IV-TR) opioid dependence recruited from substance use treatment and related services and from pharmacies administering opioid substitution pharmacotherapy. Anhedonia was assessed with the Temporal Experience of Pleasure Scale and frequency of illicit opioid use was assessed using timeline follow-back interviews. Results: There was a significant within-subject effect (β=−0.015; 95% CI −0.02 to −0.01; p=0.001), indicating that participants’ Temporal Experience of Pleasure Scale scores typically declined (i.e. anhedonia increased) following a month with above-average opioid use and Temporal Experience of Pleasure Scale scores rose (i.e. anhedonia reduced) following a month with below-average opioid use. However, Temporal Experience of Pleasure Scale scores did not significantly predict opioid use in the subsequent month (β=−0.04, 95% CI −0.20 to 0.12; p=0.651). Conclusions: Changes in illicit opioid use predict self-reported anhedonia, suggesting a possible causal relationship whereby anhedonia is likely to worsen with frequent drug use and diminish with prolonged abstinence. However, anhedonia does not appear to drive further drug use.
46
Orlova, N., and M. Shkliar. "Anhedonia at Psychiatric In-patients." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70961-7.
Full textAbstract:
Objectives:Anhedonia - loss of the capacity to experience pleasure, the inability to gain pleasure from normally pleasurable experiences - is a core clinical feature of some psychiatric illnesses and very important symptom of many somatic disorders. Its classification and treatment are very actual problems of modern psychiatry.Methods:For assessment anhedonia level at psychiatry in-patients we used the “Scale for physical and social anhedonia” Chapman L&J.Results:279 psychiatry in-patients with mental illnesses (Schizophrenia, Mood disorders and etc.) (174 men, 105 women) with a mean age of 36, 42 (±0, 9) and 123 healthy controls (75 men, 48 women) with a mean age of 36, 49 (±1, 8) were examine by this scale. 50, 54 % cases (n=141) had anhedonia (p≤0, 05). At patients with diagnostic category 298 (DSM-IV-TR) anhedonia was in 67% cases (n=93), diagnostic category 296 (DSM-IV- TR) anhedonia was in 21% cases (n=31). Other diagnostic categories DSM-IV-TR were insignificant. At healthy controls anhedonia was in 21, 1% cases (n=26). The factor analysis was selected subtypes of anhedonia in mental illnesses. We studied the correlation of level anhedonia and prolactin level in blood at patients who had treatment by atypical antipsychotic. This correlation was significant (p≤0, 05).Conclusion:Results of analyze the modern literature and owner data may tell us about pathogenetics subtypes of anhedonia. There are: in depression, in schizophrenia and in hyperprolactinemia. This clinical classification may ability for effective treatment these patients.
47
Smith, Lucie, Esther Crawley, Madeleine Riley, Megan McManus, and Maria Elizabeth Loades. "Exploring anhedonia in adolescents with Chronic Fatigue Syndrome (CFS): A mixed-methods study." Clinical Child Psychology and Psychiatry 26, no. 3 (April 16, 2021): 855–69. http://dx.doi.org/10.1177/13591045211005515.
Full textAbstract:
Background: Chronic Fatigue Syndrome (CFS/ME) may get in the way of enjoying activities. A substantial minority of adolescents with CFS/ME are depressed. Anhedonia is a core symptom of depression. Anhedonia in adolescents with CFS/ME has not been previously investigated. Method: One hundred and sixty-four adolescents, age 12 to 18, with CFS/ME completed a diagnostic interview (K-SADS) and questionnaires (HADS, RCADS). We used a mixed-methods approach to explore the experience of anhedonia and examine how common it is, comparing those with clinically significant anhedonia to those without. Results: Forty-two percent of adolescents with CFS/ME reported subclinical or clinical levels of anhedonia. Fifteen percent had clinically significant anhedonia. Thematic analysis generated two themes: (1) stopping activities that they previously enjoyed and (2) CFS/ME obstructs enjoyment. Most (72%) of those who reported clinically significant anhedonia met the depression diagnostic criteria. Those who were depressed used more negative language to describe their experience of activities than in those who were not depressed, although the themes were broadly similar. Conclusions: Experiencing pleasure from activities may be affected in CFS/ME, particularly in those who are depressed. Anhedonia may get in the way of behavioural strategies used within CFS/ME treatments.
48
Liu, C. H., and E. Tronick. "Prevalence and predictors of maternal postpartum depressed mood and anhedonia by race and ethnicity." Epidemiology and Psychiatric Sciences 23, no. 2 (August 12, 2013): 201–9. http://dx.doi.org/10.1017/s2045796013000413.
Full textAbstract:
Aims.Depression requires the presence of either depressed mood or anhedonia, yet little research attention has been focused on distinguishing these two symptoms. This study aimed to obtain the prevalence rates of these two core depression symptoms and to explore the risk factors for each symptom by race/ethnicity.Methods.2423 White, African American, Hispanic and Asian/Pacific Islander (API) women from the Massachusetts area completed the Pregnancy Risk Assessment Monitoring System (PRAMS) from 2007 to 2008.Results.Socioeconomic variables (SES) accounted for increased rates in depressed mood and anhedonia among African Americans and Hispanics compared with Whites. API women were still 2.1 times more likely to report anhedonia after controlling for SES. Stressors were associated with depressed mood across groups and associated with anhedonia for Whites and Hispanics. Having a female infant was associated with depressed mood for APIs. Being non-US born was associated with anhedonia for Whites, APIs and African Americans, but not Hispanics.Conclusions.Prevalence rates for depressed mood and anhedonia differ across race/ethnic groups and risks associated with depressed mood and anhedonia depend on the race/ethnic group, suggesting the importance of distinguishing depressed mood from anhedonia in depression assessment and careful inquiry regarding symptom experiences with a diverse patient population.
49
Fan, Jie, Yan Han, Jie Xia, Xiang Wang, Qian Liu, Yao Liu, Jingjie Lu, Quanhao Yu, Yanjie Yang, and Xiongzhao Zhu. "Childhood Neglect rather than Abuse Is More Strongly Associated with Anhedonia across Major Depression and Obsessive-Compulsive Disorder Patients and University Students." Depression and Anxiety 2023 (October 20, 2023): 1–12. http://dx.doi.org/10.1155/2023/2429889.
Full textAbstract:
Background. According to the dimensional model of adversity, the deprivation and threat dimensions of CT influence distinct neural circuits and have different developmental outcomes. The present study compared neglect and abuse subtypes which are representative of deprivation and threat dimensions of CT prediction of anhedonia in MDD and OCD patients and university students. Methods. A total of 305 patients with MDD, 152 patients with OCD, and 2110 university students fulfilled the Childhood Trauma Questionnaire to identify neglect and abuse subtypes of CT. Different aspects of anhedonia were measured. Hierarchical linear regression analysis was conducted to identify subtypes of trauma as predictors of different aspects of anhedonia in MDD and OCD patients and university students, respectively. Results. Childhood neglect, not abuse, showed association with anticipatory and state anhedonia in OCD patients and anticipatory, consummatory, physical, and state anhedonia in MDD patients and university students. Both childhood neglect and abuse were associated with social anhedonia in university students, but the neglect type showed greater magnitude. In terms of more specific categories, emotional neglect was the type of CT demonstrating strongest magnitude of association with most of the anhedonia aspects. Conclusions. Findings revealed that deprivation, rather than threat, was the more influential adversity dimension for the individuals’ anhedonia presentations.
50
Wang, Zhao, Qi Li, Lu Nie, and Ya Zheng. "Neural dynamics of monetary and social reward processing in social anhedonia." Social Cognitive and Affective Neuroscience 15, no. 9 (September 2020): 991–1003. http://dx.doi.org/10.1093/scan/nsaa128.
Full textAbstract:
Abstract Being characterized by reduced pleasure from social interaction, social anhedonia constitutes a transdiagnostic marker for various psychiatric disorders. However, the neural portrait of social anhedonia remains elusive because of heterogeneities of reward type and reward dynamics in previous studies. The present event-related potential study investigated neural dynamics in response to monetary and social rewards in social anhedonia. Event-related potential responses were examined when a high social anhedonia (HSA, N = 23) group and a low social anhedonia (LSA, N = 26) group were anticipating and consuming social and monetary rewards. LSA but not HSA participants showed an increased stimulus-preceding negativity (anticipatory phase) and and increased reward positivity (consummatory phase) for monetary as compared with social rewards. This group difference could spring from an increased relevance of social rewards or a general decline in affective responding due to a potential association between social anhedonia and depression. Our findings provide preliminary evidence for neural aberrations of the reward system in social anhedonia, which is contingent upon reward type and reward dynamics.