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Journal articles on the topic 'Angiostrongylus cantonensis'

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Published: 4 June 2021
Last updated: 20 February 2023

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1

Ash, L. R. "Angiostrongylus cantonensis." Journal of Neurology, Neurosurgery & Psychiatry 55, no. 9 (September 1, 1992): 861. http://dx.doi.org/10.1136/jnnp.55.9.861.

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2

Pien, Francis D., and Brian C. Pien. "Angiostrongylus cantonensis eosinophilic meningitis." International Journal of Infectious Diseases 3, no. 3 (1999): 161–63. http://dx.doi.org/10.1016/s1201-9712(99)90039-5.

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3

Ansdell, Vernon, and Yupaporn Wattanagoon. "Angiostrongylus cantonensis in travelers." Current Opinion in Infectious Diseases 31, no. 5 (October 2018): 399–408. http://dx.doi.org/10.1097/qco.0000000000000481.

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4

Valentyne, Hayley, David M. Spratt, Mahdis Aghazadeh, Malcolm K. Jones, and Jan Šlapeta. "The mitochondrial genome of Angiostrongylus mackerrasae is distinct from A. cantonensis and A. malaysiensis." Parasitology 147, no. 6 (February 13, 2020): 681–88. http://dx.doi.org/10.1017/s0031182020000232.

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AbstractThe native rat lungworm (Angiostrongylus mackerrasae) and the invasive rat lungworm (Angiostrongylus cantonensis) occur in eastern Australia. The species identity of A. mackerrasae remained unquestioned until relatively recently, when compilation of mtDNA data indicated that A. mackerrasae sensu Aghazadeh et al. (2015b) clusters within A. cantonensis based on their mitochondrial genomes (mtDNA). To re-evaluate the species identity of A. mackerrasae, we sought material that would be morphologically conspecific with A. mackerrasae. We combined morphological and molecular approaches to confirm or refute the specific status of A. mackerrasae. Nematodes conspecific with A. mackerrasae from Rattus fuscipes and Rattus rattus were collected in Queensland, Australia. Morphologically identified A. mackerrasae voucher specimens were characterized using amplification of cox1 followed by the generation of reference complete mtDNA. The morphologically distinct A. cantonensis, A. mackerrasae and A. malaysiensis are genetically distinguishable forming a monophyletic mtDNA lineage. We conclude that A. mackerrasae sensu Aghazadeh et al. (2015b) is a misidentified specimen of A. cantonensis. The availability of the mtDNA genome of A. mackerrasae enables its unequivocal genetic identification and differentiation from other Angiostrongylus species.
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5

Maki, Jun, and Toshio Yanagisawa. "Demonstration of carboxyl and thiol protease activities in adult Schistosoma mansoni, Dirofilaria immitis, Angiostrongylus cantonensis and Ascaris suum." Journal of Helminthology 60, no. 1 (March 1986): 31–37. http://dx.doi.org/10.1017/s0022149x00008191.

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AbstractEvidence has been presented showing two kinds of acidic protease activities in adult Schistosoma mansoni, Dirofilaria immitis, Angiostrongylus cantonensis and Ascaris suum. A haemoglobinolytic activity without adding any SH-containing compounds was maximal at pH 3.5, 2.5, 30 and 3.5 in S. mansoni, D. immitis, Angiostrongylus cantonensis and Ascaris suum respectively. The inhibitor studies demonstrated that this activity is ascribable to carboxyl protease(s). In the presence of dithiothreitol, activity on Azocoll (azo-dye coupled hide powder) was maximal at pH 4.6, 4.6, 3.5 and 5.6 in S. mansoni, D. immitis, Angiostrongylus cantonensis and Ascaris suum respectively. The effects of inhibitors demonstrated that this activity belongs to the thiol protease class. The intraspecific distribution of the protease activities was studied in some of the nematodes from which the organs could be anatomically separated. The distribution patterns of the haemoglobinolytic and azocollytic activities were quite different in An. cantonensis and much the same in As. suum. Based on the present results, acidic haemoglobinolytic activities reported in adult S. mansoni by other authors are thought to be due to carboxyl and thiol protease(s) respectively.
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6

Eamsobhana, P., P. E. Lim, and H. S. Yong. "Phylogenetics and systematics of Angiostrongylus lungworms and related taxa (Nematoda: Metastrongyloidea) inferred from the nuclear small subunit (SSU) ribosomal DNA sequences." Journal of Helminthology 89, no. 3 (March 13, 2014): 317–25. http://dx.doi.org/10.1017/s0022149x14000108.

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AbstractThe Angiostrongylus lungworms are of public health and veterinary concern in many countries. At the family level, the Angiostrongylus lungworms have been included in the family Angiostrongylidae or the family Metastrongylidae. The present study was undertaken to determine the usefulness and suitability of the nuclear 18S (small subunit, SSU) rDNA sequences for differentiating various taxa of the genus Angiostrongylus, as well as to determine the systematics and phylogenetic relationship of Angiostrongylus species and other metastrongyloid taxa. This study revealed six 18S (SSU) haplotypes in A. cantonensis, indicating considerable genetic diversity. The uncorrected pairwise ‘p’ distances among A. cantonensis ranged from 0 to 0.86%. The 18S (SSU) rDNA sequences unequivocally distinguished the five Angiostrongylus species, confirmed the close relationship of A. cantonensis and A. malaysiensis and that of A. costaricensis and A. dujardini, and were consistent with the family status of Angiostrongylidae and Metastrongylidae. In all cases, the congeneric metastrongyloid species clustered together. There was no supporting evidence to include the genus Skrjabingylus as a member of Metastrongylidae. The genera Aelurostrongylus and Didelphostrongylus were not recovered with Angiostrongylus, indicating polyphyly of the Angiostrongylidae. Of the currently recognized families of Metastrongyloidea, only Crenosomatidae appeared to be monophyletic. In view of the unsettled questions regarding the phylogenetic relationships of various taxa of the metastrongyloid worms, further analyses using more markers and more taxa are warranted.
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7

Espírito-Santo, Maria Cristina Carvalho do, Pedro Luiz Silva Pinto, Dan Jesse Gonçalves da Mota, and Ronaldo César Borges Gryschek. "THE FIRST CASE OF Angiostrongylus cantonensis EOSINOPHILIC MENINGITIS DIAGNOSED IN THE CITY OF SÃO PAULO, BRAZIL." Revista do Instituto de Medicina Tropical de São Paulo 55, no. 2 (April 2013): 129–32. http://dx.doi.org/10.1590/s0036-46652013000200012.

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Introduction:Angiostrongylus cantonensis is a natural parasite found in lung arteries of rats, which in humans may cause eosinophilic meningitis. Objective: To report the first case of eosinophilic meningitis caused by Angiostrongylus cantonensis in the city of São Paulo, Brazil. Case report: A male patient, 11 years old, living in the southern area of São Paulo, was admitted to the Pediatric Emergency Department with ongoing headaches for three days, but no fever or any other complaint. The presence of snails and rodents was reported in the peridomicile. The child was awake, lucid, oriented; muscular strength preserved, isochoric, photo reagent pupils and terminal nuchal rigidity - Glasgow Coma Scale (GCS) = 15. The laboratory tests showed a mild leukocytosis with 1736 eosinophils/mm3 and the CSF analysis disclosed 160 leukocytes/mm3 with 36% of eosinophils. The bacterial culture was negative. Computed Cerebral Tomography showed no alterations. The RT-PCR assay for detecting Angiostrongylus cantonensis larvae and DNA was negative. ELISA antibodies for IgG anti-A. cantonensis was negative in serum and undetermined in CSF and samples collected five days after the onset of symptoms. Seroconversion was observed in the sample collected 135 days later. Conclusion: the epidemiological and clinical data, the CSF alterations with eosinophilia and the seroconversion strongly suggest Angiostrongylus cantonensis eosinophilic meningitis.
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8

AGHAZADEH, MAHDIS, MARINA C. HARVIE, HELEN C. OWEN, CAROLINA VERÍSSIMO, KIERAN V. ALAND, SIMON A. REID, REBECCA J. TRAUB, DONALD P. McMANUS, JAMES S. McCARTHY, and MALCOLM K. JONES. "Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection." Parasitology 143, no. 10 (June 9, 2016): 1243–51. http://dx.doi.org/10.1017/s003118201600069x.

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SUMMARYThis study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot.
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9

Ramos-Robledo, Alejandro, Christian Meijides-Mejías, Rolando Zamora-Fung, and Alberto Juan Dorta-Contreras. "Meningoencefalitis eosinofílica por Angiostrongylus cantonensis." Archivos de Neurociencias 25, no. 2 (August 3, 2020): 45–56. http://dx.doi.org/10.31157/an.v25i2.237.

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Angiostrongylus cantonensis (A. cantonensis) es un helminto que constituye la principal causa de meningoencefalitis eosinofílica en el mundo y endémica en muchas partes del mundo. El objetivo de este trabajo es revisar la literatura publicada sobre el tema sobre el diagnóstico y tratamiento de la enfermedad que ocasiona, la fisiopatología de la enfermedad, casos interesantes y las particularidades de esta donde no existan hábitos de ingerir caracoles crudos y no existan otras etiologías. Se revisaron 37 artículos sobre la enfermedad en revistas nacionales e internacionales de acceso abierto que abarca la base de datos Scopus en el período de 1957 a octubre de 2019. Se confirma que la liberación de sustancias tóxicas, por lisis masiva de las larvas del parásito, produce el proceso inflamatorio en el sistema nervioso central y de esta manera se instaura finalmente la meningoencefalitis eosinofílica. Las manifestaciones clínicas más comunes de la enfermedad incluyen cefalea intensa, rigidez de nuca, náuseas, vómitos y parestesias. La fiebre se presenta en aproximadamente en la tercera parte de los enfermos. Los síntomas y los signos son a menudo leves o moderados, pero pueden llegar el coma. El diagnóstico está basado en los factores epidemiológicos, cuadro clínico presentado, así como los hallazgos positivos de los métodos diagnósticos inmunológicos y por PCR y los reibergramas como auxiliares. El tratamiento presenta alternativas al tratamiento sintomático con la talidomida y albendazol y la terapéutica combinada Interleucina-12 (IL-12) /Albendazol ensayada hasta ahora en ratas.
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10

Ramos-Robledo, Alejandro, Christian Meijides-Mejías, Rolando Zamora-Fung, and Alberto Juan Dorta-Contreras. "Meningoencefalitis eosinofílica por Angiostrongylus cantonensis." Archivos de Neurociencias 25, no. 2 (August 3, 2020): 45–56. http://dx.doi.org/10.31157/archneurosciencesmex.v25i2.237.

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Angiostrongylus cantonensis (A. cantonensis) es un helminto que constituye la principal causa de meningoencefalitis eosinofílica en el mundo y endémica en muchas partes del mundo. El objetivo de este trabajo es revisar la literatura publicada sobre el tema sobre el diagnóstico y tratamiento de la enfermedad que ocasiona, la fisiopatología de la enfermedad, casos interesantes y las particularidades de esta donde no existan hábitos de ingerir caracoles crudos y no existan otras etiologías. Se revisaron 37 artículos sobre la enfermedad en revistas nacionales e internacionales de acceso abierto que abarca la base de datos Scopus en el período de 1957 a octubre de 2019. Se confirma que la liberación de sustancias tóxicas, por lisis masiva de las larvas del parásito, produce el proceso inflamatorio en el sistema nervioso central y de esta manera se instaura finalmente la meningoencefalitis eosinofílica. Las manifestaciones clínicas más comunes de la enfermedad incluyen cefalea intensa, rigidez de nuca, náuseas, vómitos y parestesias. La fiebre se presenta en aproximadamente en la tercera parte de los enfermos. Los síntomas y los signos son a menudo leves o moderados, pero pueden llegar el coma. El diagnóstico está basado en los factores epidemiológicos, cuadro clínico presentado, así como los hallazgos positivos de los métodos diagnósticos inmunológicos y por PCR y los reibergramas como auxiliares. El tratamiento presenta alternativas al tratamiento sintomático con la talidomida y albendazol y la terapéutica combinada Interleucina-12 (IL-12) /Albendazol ensayada hasta ahora en ratas.
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11

Pansini, M., and L. Winter. "Eosinophile Meningoenzephalitis durch Angiostrongylus cantonensis." Radiologie up2date 10, no. 01 (March 2010): 7–10. http://dx.doi.org/10.1055/s-0029-1243912.

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12

Alicata, JosephE. "ANGIOSTRONGYLUS CANTONENSIS AND EOSINOPHILIC MENINGITIS." Lancet 332, no. 8624 (December 1988): 1367–68. http://dx.doi.org/10.1016/s0140-6736(88)90905-1.

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13

Wang, Q. P., Z. D. Wu, J. Wei, R. L. Owen, and Z. R. Lun. "Human Angiostrongylus cantonensis: an update." European Journal of Clinical Microbiology & Infectious Diseases 31, no. 4 (July 5, 2011): 389–95. http://dx.doi.org/10.1007/s10096-011-1328-5.

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14

Aishwarya, Ankita, UmaSharan Tiwari, Shashi Gandhi, and Priya Sisodia. "Angiostrongylus cantonensis in anterior chamber." Indian Journal of Ophthalmology 67, no. 1 (2019): 158. http://dx.doi.org/10.4103/ijo.ijo_843_18.

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15

Stokes, Vicki L., David M. Spratt, Peter B. Banks, Roger P. Pech, and Richard L. Williams. "Occurrence of Angiostrongylus species (Nematoda) in populations of Rattus rattus and Rattus fuscipes in coastal forests of south-eastern Australia." Australian Journal of Zoology 55, no. 3 (2007): 177. http://dx.doi.org/10.1071/zo06061.

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The distributions of the introduced nematode parasite, Angiostrongylus cantonensis, and the native Angiostrongylus mackerrasae in Australia are poorly understood. We sampled rodents and/or their faeces, and intermediate gastropod hosts for the presence of Angiostrongylus species in coastal forests surrounding Jervis Bay in south-eastern Australia. We found A. cantonensis in populations of introduced Rattus rattus in forests to the north of Jervis Bay, and A. mackerrasae in native Rattus fuscipes in forests to the south of Jervis Bay. The apparent geographical separation of these lungworm species may be a consequence of host specificity and negative associations between R. rattus and R. fuscipes that results from interspecific competition. A. cantonensis was regularly found in R. rattus or their faeces across 9 of 12 study sites north of Jervis Bay, and three species of snail common to the area were suitable intermediate hosts. This has potential negative implications for native wildlife and human visitors to these forests, because A. cantonensis infection causes zoonotic disease (neuro-angiostrongyliasis) in humans and a wide range of bird and mammal hosts. Management of pest rodents in the study area is warranted.
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16

Vitta, A., W. Polsut, C. Fukruksa, T. Yimthin, A. Thanwisai, and P. Dekumyoy. "Levels of infection with the lungworm Angiostrongylus cantonensis in terrestrial snails from Thailand, with Cryptozona siamensis as a new intermediate host." Journal of Helminthology 90, no. 6 (January 15, 2016): 737–41. http://dx.doi.org/10.1017/s0022149x15001042.

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AbstractAngiostrongylus cantonensis is primarily considered an emerging infectious agent of eosinophilic meningitis or meningoencephalitis with a worldwide distribution. Rodents and snails are important invasive hosts for transmission and expansion of A. cantonensis. The objective of this study was to investigate infection levels of A. cantonensis in snails, the most important natural intermediate host. Our study location was Mueang Kamphaeng Phet district, Kamphaeng Phet Province, and was undertaken between October and December 2012. A total of 2228 freshwater and terrestrial snails were collected, comprising 1119 Filopaludina spp., 409 Pomacea caniculata, 275 Achatina fulica and 425 Cryptozona siamensis. Angiostrongylus larvae were isolated by artificial digestion methods following Baermann's techniques. A low prevalence and intensity of A. cantonensis were observed in A. fulica, while higher numbers were found in C. siamensis. None of the Filopaludina spp. and Pomacea caniculata were infected with A. cantonensis. Molecular characterization was performed by analysing the 264 bp of cytochrome c oxidase subunit I (COI). Three COI sequences of Angiostrongylus were identical to A. cantonensis with 91–99% identity. Cryptozona siamensis has not previously been recorded as an intermediate host for A. cantonensis in Thailand. The infection of A. cantonensis identified in the natural intermediate hosts is new and important information to assist in the prevention and control of human angiostrongyliasis.
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17

Qvarnstrom, Yvonne, Ana Cristina Aramburu da Silva, John L. Teem, Robert Hollingsworth, Henry Bishop, Carlos Graeff-Teixeira, and Alexandre J. da Silva. "Improved Molecular Detection of Angiostrongylus cantonensis in Mollusks and Other Environmental Samples with a Species-Specific Internal Transcribed Spacer 1-Based TaqMan Assay." Applied and Environmental Microbiology 76, no. 15 (June 11, 2010): 5287–89. http://dx.doi.org/10.1128/aem.00546-10.

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ABSTRACT Angiostrongylus cantonensis is the most common cause of human eosinophilic meningitis. Humans become infected by ingesting food items contaminated with third-stage larvae that develop in mollusks. We report the development of a real-time PCR assay for the species-specific identification of A. cantonensis in mollusk tissue.
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18

Cui, Yun, Ming Shen, and Shujing Meng. "Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis." Clinical Imaging 35, no. 3 (May 2011): 180–83. http://dx.doi.org/10.1016/j.clinimag.2010.05.004.

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19

Murugan, SBala. "Commentary: Angiostrongylus cantonensis in anterior chamber." Indian Journal of Ophthalmology 67, no. 1 (2019): 161. http://dx.doi.org/10.4103/ijo.ijo_1511_18.

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20

Panackel, C., Vishad, G. Cherian, K. Vijayakumar, and RN Sharma. "EOSINOPHILIC MENINGITIS DUE TO ANGIOSTRONGYLUS CANTONENSIS." Indian Journal of Medical Microbiology 24, no. 3 (July 2006): 220–21. http://dx.doi.org/10.1016/s0255-0857(21)02355-0.

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21

Purohit, A. K., I. Dinakar, C. Sundaram, and K. S. Ratnakar. "Angiostrongylus cantonensis abscess in the brain." Journal of Neurology, Neurosurgery & Psychiatry 54, no. 11 (November 1, 1991): 1015–16. http://dx.doi.org/10.1136/jnnp.54.11.1015-a.

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22

Noskin, G. A., M. B. McMenantin, and S. M. Grohmann. "Eosinophilic meningitis due to Angiostrongylus cantonensis." Neurology 42, no. 7 (July 1, 1992): 1423. http://dx.doi.org/10.1212/wnl.42.7.1423.

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23

HSU, WEN-YING, JIA-YUH CHEN, CHAO-TONG CHIEN, CHING-SHIANG CHI, and NIEN-TSU HAN. "Eosinophilic meningitis caused by Angiostrongylus cantonensis." Pediatric Infectious Disease Journal 9, no. 6 (June 1990): 443–45. http://dx.doi.org/10.1097/00006454-199006000-00016.

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24

Lv, Shan, Xiao-Nong Zhou, and Jason R. Andrews. "Eosinophilic Meningitis Caused by Angiostrongylus cantonensis." ACS Chemical Neuroscience 8, no. 9 (July 13, 2017): 1815–16. http://dx.doi.org/10.1021/acschemneuro.7b00233.

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25

Liu, I. Hsien, Yu-Mei Chung, Shih-Jen Chen, and Wen-Long Cho. "Necrotizing Retinitis Induced by Angiostrongylus cantonensis." American Journal of Ophthalmology 141, no. 3 (March 2006): 577–79. http://dx.doi.org/10.1016/j.ajo.2005.09.033.

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26

So, N. N. C., P. C. L. Wong, and R. C. Ko. "Angiostrongylus cantonensis: Characterization of Thymidylate Synthetase." Experimental Parasitology 79, no. 4 (December 1994): 526–35. http://dx.doi.org/10.1006/expr.1994.1113.

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27

Dusitsittipon, S., U. Thaenkham, D. Watthanakulpanich, P. Adisakwattana, and C. Komalamisra. "Genetic differences in the rat lungworm, Angiostrongylus cantonensis (Nematoda: Angiostrongylidae), in Thailand." Journal of Helminthology 89, no. 5 (June 16, 2014): 545–51. http://dx.doi.org/10.1017/s0022149x14000388.

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AbstractThis study surveyed the genetic differences among Angiostrongylus cantonensis (A. cantonensis) using the mitochondrial cytochrome b (cytb) gene. Partial cytb sequences were determined for 91 worms from eight locations in Thailand. Using morphological techniques, the nematodes were found to be A. cantonensis. Phylogenetic analysis found two main clades, which were subdivided into four subclades (clusters). Haplotype network analysis showed that 11 distinct cytb haplotypes were also present in four groups of A. cantonensis. There was no observable relationship between the genetic differentiation of gene flow and geographical distance. This low genetic variation and geographical distribution of A. cantonensis in each location indicates a founder effect, which may have resulted from multiple independent origins, and suggests that haplotypes migrated from endemic areas via human-related activities.
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28

Mahajan, R. K., and D. M. Renapurkar. "Cryopreservation of Angiostrongylus cantonensis third-stage larvae." Journal of Helminthology 67, no. 3 (September 1993): 233–37. http://dx.doi.org/10.1017/s0022149x00013171.

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AbstractAn optimum protocol for the cryopreservation of third-stage larvae (L3) of Angiostrongylus cantonensis was determined by: (i) use of different dimethyl sulphoxide (DMSO) concentrations; (ii) use of different FBS concentrations in RPMI-1640 medium; and (iii) variation in the thawing temperature. Studies showed that with Concentrations of DMSO at 4·8% and FBS at 40% and a thawing temperature of 43°C, L3 survival assessed by motility was highest at 56%. The infectivity of the cryopreserved L3 of A. cantonensis was 20% compared to controls obtained from slugs.
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29

Noda, Shinichi, Ryuichi Uchikawa, Seiken Matayoshi, Yohsuke Watanabe, and Atsuo Sato. "Observations on the transmission of Angiostrongylus cantonensis from snail to rodent." Journal of Helminthology 61, no. 3 (September 1987): 241–46. http://dx.doi.org/10.1017/s0022149x00010099.

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ABSTRACTA survey of Angiostrongylus cantonensis was carried out to investigate the mode of transmission from molluse to rat in a fixed study area of Yoron Island from 1979 to 1982. Rattus rattus was found to be infected with a small number of worms in spite of heavy infection with third-stage larvae in Achatina fulica and an abundance of this snail in the area. Natural infection and/or susceptibility with A. cantonensis were confirmed in three small snail species. Bradybaena circulus, Fruticicola despecta and Luchuena reticulata. Young A. fulica was found to be infected with fewer third-stage larvae than mature A. fulica. It was concluded that molluscs which were infected with a small number of third-stage larvae of A. cantonensis play an important role in maintaining the life cycle of A. cantonensis. The percentage of rat stomachs containing molluse tissue was relatively low, and the incidence and infection was low in rats. Infection with A. cantonensis did not occur very often in R. rattus in nature.
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Lam, Ho Yin Pekkle, Ting-Ruei Liang, Shinn-Jong Jiang, and Shih-Yi Peng. "Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice." Biomolecules 10, no. 7 (July 5, 2020): 1001. http://dx.doi.org/10.3390/biom10071001.

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Currently, Angiostrongylus cantonensis infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms. Therefore, treatment usually involves co-administration of corticosteroids to limit the inflammatory reaction. Corticosteroids play a useful role in suppressing inflammation in the brain; however, long-term usage or high dosage may make it problematic.Schisandrin B, an active ingredient from Schisandra chinensis, has been shown to have anti-inflammatory effects on the brain. This study aimed to investigate the effects and potential of schisandrin B in combination with albendazole to treat Angiostrongylus-induced meningoencephalitis. Here, we show that albendazole-schisandrin B co-treatment suppressed neuroinflammation in Angiostrongylus-infected mice and increased the survival of the mice. Accordingly, albendazole-schisandrin B co-treatment significantly inhibited inflammasome activation, pyroptosis, and apoptosis. The sensorimotor functions of the mice were also repaired after albendazole-schisandrin B treatment. Immune response was shown to shift from Th2 to Th1, which reduces inflammation and enhances immunity against A. cantonensis. Collectively, our study showed that albendazole-schisandrin B co-therapy may be used as an encouraging treatment for Angiostrongylus-induced meningoencephalitis.
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Maki, Jun, and Toshio Yanagisawa. "Larvicidal effect of flubendazole on Angiostrongylus cantonensis in mice with various worm burdens." Journal of Helminthology 59, no. 4 (December 1985): 301–2. http://dx.doi.org/10.1017/s0022149x00025839.

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Song, S. L., H. S. Yong, and P. Eamsobhana. "Angiostrongylus mackerrasae and A. cantonensis (Nematoda: Metastrongyloidea) belong to same genetic lineage: evidence from mitochondrial protein-coding genes." Journal of Helminthology 92, no. 4 (July 11, 2017): 524–29. http://dx.doi.org/10.1017/s0022149x1700061x.

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AbstractAngiostrongylus mackerrasae is a parasitic nematode of rats found in Australia. When first reported, it was referred to as A. cantonensis. Recent molecular studies, including the mitochondrial genome, indicate that it is highly similar to A. cantonensis. These studies did not include A. malaysiensis, another member of the A. cantonensis species complex, for comparison. The present study examined the genetic distance and phylogenetic relationship between the component taxa (A. cantonensis, A. mackerrasae and A. malaysiensis) of the A. cantonensis species complex, based on the 12 protein-coding genes (PCGs) of their mitochondrial genome. Both the nucleotide and amino acid sequences were analysed. Angiostrongylus mackerrasae and A. cantonensis are members of the same genetic lineage and both are genetically distinct from A. malaysiensis. The genetic distance based on concatenated nucleotide sequences of 12 mt-PCGs between A. mackerrasae and A. cantonensis from Thailand is p = 1.73%, while that between the Thai and Chinese taxa of A. cantonensis is p = 3.52%; the genetic distance between A. mackerrasae and A. cantonensis from China is p = 3.70%. The results indicate that A. mackerrasae and A. cantonensis belong to the same genetic lineage, and that A. mackerrasae may be conspecific with A. cantonensis. It remains to be resolved whether A. mackerrasae is conspecific with A. cantonensis or undergoing incipient speciation.
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Phan, Hai Thanh, Kiem Hao Tran, and Huu Son Nguyen. "Eosinophilic Meningitis due to Angiostrongylus cantonensis in Children." Case Reports in Neurology 13, no. 1 (March 19, 2021): 184–89. http://dx.doi.org/10.1159/000512809.

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Meningoencephalitis is not a rare disease in children. However, eosinophilic meningitis due to <i>Angiostrongylus cantonensis</i> is unusual in the pediatric population. We describe the case of a 12-year-old girl from the central area of Vietnam with eosinophilic meningitis due to <i>A. cantonensis</i>. The patient lived in a rural area, where farming is widespread, and presented with fever and headache. Laboratory results showed peripheral eosinophilia, a cerebrospinal fluid white blood cell count of 730/mm<sup>3</sup> with 65% eosinophils. Cerebrospinal fluid ELISA was positive for <i>A. cantonensis</i>, and blood ELISA was positive for <i>A. cantonensis</i>. The presentation was consistent with a diagnosis of <i>A. cantonensis</i> eosinophilic meningitis. The patient recovered fully after administration of albendazole (200 mg/day for 2 weeks), as well as intravenous dexamethasone (0.6 mg/kg/day every 8 h) and mannitol (1.5 g/kg/day every 8 h) for the first 3 days, followed by 5 days of oral prednisolone (2 mg/kg/day).
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34

Qvarnstrom, Yvonne, James J. Sullivan, Henry S. Bishop, Robert Hollingsworth, and Alexandre J. da Silva. "PCR-Based Detection of Angiostrongylus cantonensis in Tissue and Mucus Secretions from Molluscan Hosts." Applied and Environmental Microbiology 73, no. 5 (December 28, 2006): 1415–19. http://dx.doi.org/10.1128/aem.01968-06.

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ABSTRACT Angiostrongylus cantonensis is a common cause of human eosinophilic meningitis. Recent outbreaks of this infection have shown that there is a need to determine the distribution of this nematode in the environment in order to control transmission. A. cantonensis is generally identified morphologically in the molluscan intermediate host by microscopic examination, which can be labor-intensive. The aim of this study was to develop a PCR-based method to detect A. cantonensis directly from molluscan tissue. A total of 34 Parmarion cf. martensi (Simroth) semislugs, 25 of which were naturally infected with A. cantonensis, were used to develop this assay. Tissue pieces (approximately 25 mg) were digested with pepsin-HCl to recover third-stage larvae for morphological identification or were used for DNA extraction. PCR primers were designed to amplify 1,134 bp from the Angiostrongylus 18S rRNA gene, and the amplicons produced were sequenced for identification at the species level. Both microscopy and the PCR-DNA sequencing analysis indicated that the same 25 semislugs were positive for A. cantonensis, showing that the two methods were equally sensitive and specific for this application. However, morphological detection requires access to living mollusks, whereas molecular analysis can also be performed with frozen tissue. The PCR-DNA sequencing method was further evaluated using tissue from Veronicella cubensis (Pfeiffer) slugs and mucus secretions from infected P. martensi. To our knowledge, this is the first use of a PCR-based method to confirm the presence of A. cantonensis in mollusks collected in the environment.
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Al Hammoud, Roukaya, Stacy L. Nayes, James R. Murphy, Gloria P. Heresi, Ian J. Butler, and Norma Pérez. "Angiostrongylus cantonensis Meningitis and Myelitis, Texas, USA." Emerging Infectious Diseases 23, no. 6 (June 2017): 1037–38. http://dx.doi.org/10.3201/eid2306.161683.

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Diao, Zongli, Chenghong Yin, and Erhu Jin. "Myelitis Caused by Infection of Angiostrongylus cantonensis." American Journal of Tropical Medicine and Hygiene 83, no. 6 (December 6, 2010): 1176–77. http://dx.doi.org/10.4269/ajtmh.2010.10-0418.

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37

Casadevall, M., E. Aslangul, A. Datry, T. A. Szwebel, L. Gagliardi, M. Cornet, and C. Le Jeunne. "Méningite à éosinophiles liée à Angiostrongylus cantonensis." La Revue de Médecine Interne 30 (December 2009): S435—S436. http://dx.doi.org/10.1016/j.revmed.2009.10.306.

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Joshua, George W. P., Ray Y. Chuang, Soo C. Cheng, Shu F. Lin, Rocky S. Tuan, and Ching C. Wang. "The spliced leader gene of Angiostrongylus cantonensis." Molecular and Biochemical Parasitology 46, no. 2 (June 1991): 209–17. http://dx.doi.org/10.1016/0166-6851(91)90045-8.

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Lee, J. D., J. J. Wang, J. H. Chang, L. Y. Chung, E. R. Chen, and C. M. Yen. "Role of T cell subpopulations in mice infected with Angiostrongylus cantonensis." Journal of Helminthology 70, no. 3 (September 1996): 211–14. http://dx.doi.org/10.1017/s0022149x0001542x.

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AbstractWhen C57BL/6 mice were infected with Angiostrongylus cantonensis, the percentage of T helper (CD4+) cells and T supressor (CD8+) cells in peripheral blood increased weekly until the third and seventh week respectively, and then gradually decreased. C57BL/6 mice were depleted of CD4+ and CD8+ T cells by in vivo injection of anti-CD4 and anti-CD8 monoclonal antibodies, respectively, and then infected with A. cantonensis. There were significantly more and less worms recovered in the mice depleted of CD4+ and CD8+ T cells respectively than in undepleted mice. Discrete subpopulations of T cells from mice exposed to A. cantonensis for 3 weeks or 7 weeks were adoptively transferred to syngeneic recipients which were then given a challenge infection. Protection was mediated by a CD4+ T cell population present in mice after 3 weeks of infection but was not demonstrable with cells taken 7 weeks after infection. When CD4+ T cells obtained from 3-week infected mice were mixed with 5% CD8+ T cells obtained from mice infected for 7 weeks, no significant transfer of resistance was observed. Thus, immune responses to A. cantonensis in mice were regulated by discrete subpopulations of T lymphocytes.
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Wang, Lian-Chen, David Chao, and Eng-Rin Chen. "Experimental infection routes of Angiostrongylus cantonensis in mice." Journal of Helminthology 65, no. 4 (December 1991): 296–300. http://dx.doi.org/10.1017/s0022149x00010890.

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ABSTRACTStomach intubation is the most common method used in the experimental infection of animals with Angiostrongylus cantonensis. In order to compare the effectiveness of other possible transmission methods, groups of BALB/c mice were given infective third-stage larvae of A. cantonensis by different routes including intraperitoneal or subcutaneous injections, and penetration of anal mucosa, vaginal mucosa, conjunctival mucosa, lacerated skin, unabraded skin, foot pad and tail skin, while stomach intubation was used as control. Recovery of fifth-stage larvae was higher in mice inoculated with third-stage larvae subcutaneously. Successful infections were established through all experimental transmission routes except tail skin penetration. This study suggests that oral infection may not be the only route for the transmission of human angiostrongyliasis, and subcutaneous infection may be a better method for experimental infection.
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Solórzano Alava, Luis, Yolanda Narváez, Francisco Sánchez Amador, and Julio Ortiz. "Alteraciones histopatológicas y microorganismos hallados en Rattus norvegicus infectadas con Angiostrongylus cantonensis." Revista de Investigaciones Veterinarias del Perú 29, no. 2 (May 31, 2018): 472. http://dx.doi.org/10.15381/rivep.v29i2.14500.

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Las ratas (Rattus sp) son los hospederos definitivos del nematodo Angiostrongylus cantonensis. El objetivo de este estudio fue identificar los órganos afectados por la presencia de A. cantonensis (adultos) y el tipo de daño causado, así como establecer la presencia de microorganismos (bacterias y hongos) que podrían encontrarse en dichas lesiones. El estudio se realizó en 2014-2016 con 65 especímenes (60 infectadas en el laboratorio, que presentaron la larva L1 en sus deposiciones y 5 no infectadas como grupo control). Las muestras de tejido pulmonar y cardiaco fueron obtenidas en diferentes días pos-infección (dpi), teñidas con Gram y sembradas en agar sangre de caballo, agar MacConkey, medio Tioglicolato y, medio Cistina Tripteína Agar (CTA). Se observaron alteraciones macro y microscópicas en tejido pulmonar y cardiaco, así como microorganismos en lesiones pulmonares tanto en el Gram como en los cultivos bacteriológicos. Se observó tejido pulmonar endurecido, células polinucleares, pus, cambios de color en el pericardio y alteraciones en el peso de los órganos. En conclusión, las ratas infectadas con Angiostrongylus cantonensis presentaron diversas alteraciones histológicas en sus órganos internos, con relación al grupo control, así como bacterias que podrían complicar el cuadro clínico.
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42

M Spratt, David. "Neuroangiostrongyliasis: disease in wildlife and humans." Microbiology Australia 26, no. 2 (2005): 63. http://dx.doi.org/10.1071/ma05063.

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Angiostrongyliasis is a neurological disease caused by the rat lungworm, Angiostrongylus cantonensis, one of the most catholic nematode parasites of vertebrates. Infection has occurred accidentally in humans, a broad spectrum of eutherian and marsupial mammals, and recently in birds.
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Jarvi, Susan Irene, Stefano Quarta, Praphathip Eamsobhana, Kathleen Howe, Steven Jacquier, Robert McHugh, Kuikei Kramer, and McKayla Meyers. "Human exposure to Angiostrongylus cantonensis on east Hawaii Island." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 57.16. http://dx.doi.org/10.4049/jimmunol.198.supp.57.16.

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Abstract A study was completed to quantify exposure to Angiostrongylus cantonensis among 435 human volunteers from east Hawaii Island. Volunteers completed a questionnaire and provided blood samples (at Puna Community Medical Center and Clinical Labs of Hawaii). Serum was screened by indirect ELISA using crude antigen isolated from adult A. cantonensis harvested from wild Hawaiian rats, and 28% tested positive. Of volunteers who defined themselves as definitively diagnosed by a clinician (n = 15), 67% were positive by ELISA and reported being infected in 2004 and later. Of those self-reported as previously infected with A. cantonensis (n=105), 31% were positive; those who self-reported as uninfected (n=315), 25% tested positive by ELISA. All ELISA positives were further tested by ELISA dot-blot using the more definitive 31 kDa protein isolated from Thailand adult female A. cantonensis as antigen. Of the 186 tested by ELISA dot-blot, 30% were positive. Of the 15 definitively diagnosed, 47% were positive and reported being infected in 2007 and later, however antibodies were also detected in a volunteer infected in 1981, which may have been due to a more recent re-exposure. Of those self-reported as previously infected (n=45), 29% were positive and those who self-reported as uninfected (n=126), 29% were positive. The sensitivity of the ELISA dot-blot as compared with ELISA was 100%, but the specificity was only 25% due to the high number of false positives by crude antigen ELISA. No samples were dot blot positive and ELISA negative, thus the ELISA test appears to be an effective initial screening method and the ELISA dot-blot appears to have good efficacy as a diagnostic. Human exposure to A. cantonensis in east Hawaii is higher than previously thought.
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Solórzano-Alava, Luis, Francisco Sánchez-Amador, and Talia Valverde. "Angiostrongylus (Parastrongylus) cantonensis en huéspedes intermediarios y definitivos en Ecuador, 2014-2017." Biomédica 39, no. 2 (June 15, 2019): 370–84. http://dx.doi.org/10.7705/biomedica.v39i3.4387.

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Introducción. Angiostrongylus cantonensis es un serio problema de salud pública y está ampliamente distribuido en el país. Cuando el parásito infecta a los caracoles terrestres Achatina, se enquista en su interior y puede infectar accidentalmente a las personas y otros mamíferos.Objetivo. Establecer la distribución geográfica de A. cantonensis en huéspedes intermediarios (Achatina fulica) y definitivos (Rattus spp.) en Ecuador entre el 2014 y el 2017.Materiales y métodos. Se recolectaron 2.908 ejemplares de A. fulica en 16 provincias utilizando el método de captura por unidad de esfuerzo durante 30 minutos. Se capturaron 211 ejemplares de las especies huéspedes, de los cuales 20 eran Rattus rattus y 191 R. norvegicus. Los ejemplares fueron transportados para su análisis al Instituto Nacional de Salud Pública e Investigación en Guayaquil.En los tejidos del caracol se identificaron y se contabilizaron larvas L3 que luego se inocularon en ratas de laboratorio para reproducir el ciclo de vida. En los roedores se disecaron los cerebros, los corazones, las arterias pulmonares y los pulmones, y se identificaron los parásitos por morfología taxonómica.Resultados. De los caracoles recolectados se encontraron 441 positivos para A. cantonensis (15,2 %) y un total de 6.166 larvas L3. En los ejemplares Rattus spp. capturados (211), 77 (36,5 %) estaban infectados con A. cantonensis, con un total de 220 parásitos (larvas L4-L5 y adultos).Conclusiones. Se constató la presencia de A. cantonensis en varias provincias, lo que confirma el carácter endémico de esta zoonosis en el territorio nacional. La presencia de Rattus spp., huésped definitivo del parásito, y de huéspedes intermediarios, indica el potencial zoonótico de esta infección parasitaria.
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Busse, Jennifer, David Gottlieb, Krystal Ferreras, Jennifer Bain, and William Schechter. "Pharmacological Management of Severe Neuropathic Pain in a Case of Eosinophilic Meningitis Related to Angiostrongylus cantonensis." Case Reports in Anesthesiology 2018 (October 17, 2018): 1–4. http://dx.doi.org/10.1155/2018/5038272.

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Angiostrongylus cantonensis, the rat lungworm, is the most common infectious cause of eosinophilic meningitis and can be fatal. The parasite can be found throughout Southeast Asia and Pacific Islands and the global distribution is expanding. We present the case of a fourteen-year-old female who had previously traveled to Hawaii and developed severe neuropathic pain related to A. cantonensis infection refractory to gabapentin and pregabalin monotherapy, who was eventually managed with an ultralow dose ketamine infusion, methadone, and serotonin-norepinephrine reuptake inhibitor.
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Dorta-Contreras, Alberto J., Barbara Padilla-Docal, Juan M. Moreira, Luiggi Martini Robles, Jenny Muzzio Aroca, Fernando Alarcón, and Raisa Bu-Coifiu- Fanego. "Neuroimmunological findings of Angiostrongylus cantonensis meningitis in ecuadorian patients." Arquivos de Neuro-Psiquiatria 69, no. 3 (June 2011): 466–69. http://dx.doi.org/10.1590/s0004-282x2011000400011.

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Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador. METHOD: Eight young adult patients from the two outbreaks were studied. IgA, IgM, IgG and albumin in cerebrospinal fluid and serum were quantified and plotted in cerebrospinal fluid/serum quotient diagrams (Reibergrams). The anamnesis on the patients included asking about any consumption of raw snails, symptoms and harm caused. RESULTS: Mean eosinophilia of 7.5% and 26% in serum and cerebrospinal fluid respectively was observed, as well as a moderate increase in total proteins. The most frequent pattern of intrathecal synthesis was observed in three classes of immunoglobulins. Intrathecal synthesis of IgM was observed in all cases two weeks after the first symptoms appeared. CONCLUSION: The intrathecal synthesis patterns of eosinophilic meningitis due to Angiostrongylus cantonensis, facilitated by cerebrospinal fluid analysis, were similar to those of previous cases from abroad.
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Varela-M, Rubén E., Jinney Stefany Arias, and Luz Elena Velásquez. "Standardization of a multiplex real-time PCR test for the identification of Angiostrongylus cantonensis, A. costaricensis and A. vasorum." Biomédica 38, no. 1 (March 15, 2018): 111. http://dx.doi.org/10.7705/biomedica.v38i0.3407.

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Introducción. En el mundo, las angiostrongilosis de mayor impacto en salud humana y animal son ocasionadas por Angiostrongylus cantonensis, A. costaricensis y A. vasorum. En las personas, las formas clínicas son la meningitis eosinofílica y la angiostrongilosis abdominal, y, en los mamíferos cánidos, el daño cardiopulmonar. Se las consideran enfermedades emergentes debido a la propagación mundial del caracol africano Lissachatina fulica, un huésped intermediario de los parásitos. Los escasos métodos de identificación de Angiostrongylus spp. no son muy específicos ni sensibles y son costosos. Se necesita urgentemente una herramienta diagnóstica asequible, sensible y específicapara el manejo de las angiostrongilosis humana y la animal.Objetivo. Desarrollar una prueba de PCR múltiple en tiempo real (qPCR) para identificar las tres especies patógenas de Angiostrongylus.Materiales y métodos. Mediante un análisis bioinformático se seleccionó una secuencia del genoma ITS-2 de Angiostrongylus para garantizar la especificidad del cebador y las sondas. El ADN de los parásitos adultos (control positivo) y de las larvas se extrajo con el estuche DNeasyBlood & Tissue®.Las reacciones de la PCR cuantitativa se ejecutaron en un termociclador Smartcycler Cepheid®, usando el estuche de mezcla maestra QuantiTect®. Como control negativo, se utilizó ADN humano, de otros parásitos y del caracol africano.Resultados. Los valores del ciclo umbral para los controles positivos de ADN fueron: 21 para Angiostrongylus cantonensis, 22 para A. costaricensis y 31 para A. vasorum. En los controles negativos, el ciclo umbral fue cero. La qPCR mostró una eficiencia de amplificación de 2 (100 %).Conclusiones. En el laboratorio se estandarizó una qPCR múltiple para tres especies clínicamente significativas de Angiostrongylus.
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Ying, Feng, Zheng Cunjing, Feng Feng, Wan Shuo, Zeng Xin, Xie Fukang, and Wu Zhongdao. "Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition." Mediators of Inflammation 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/3513651.

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Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during A. cantonensis infection. In addition, IL-17A-neutralizing antibody was applied to treat A. cantonensis-infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of A. cantonensis infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by A. cantonensis and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by A. cantonensis.
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Ooi, H. K., K. Ishii, J. Inohara, and M. Kamiya. "Effect of irradiation on the viability of Angiostrongylus cantonensis and A. costaricensis infective larvae." Journal of Helminthology 67, no. 3 (September 1993): 238–42. http://dx.doi.org/10.1017/s0022149x00013183.

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AbstractInfective larvae (third-stage larvae) of both Angiostrongylus cantonensis and A. costaricensis from their snail intermediate host were subjected to either X-ray or gamma-ray irradiation. The viability of the irradiated larvae was assayed by oral inoculation of the larvae into rodents (A. cantoflensis in mice and rats, A. costaricensis in mice only). From the results of worm recovery, the minimal dose of irradiation that inhibited the infectivity of the third-stage larvae of A. cantonensis and A. costaricensis was 2 and 4 kGy, respectively.
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Kim, D. Y., T. B. Stewart, R. W. Bauer, and M. Mitchell. "Parastrongylus (=Angiostrongylus) cantonensis Now Endemic in Louisiana Wildlife." Journal of Parasitology 88, no. 5 (October 2002): 1024. http://dx.doi.org/10.2307/3285552.

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