Dissertations / Theses on the topic 'Angiogenesis'
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PARMA, LAURA. "INTRAPLAQUE ANGIOGENESIS AND THERAPEUTIC TARGETING OF ANGIOGENESIS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/777113.
Full textSmall, Gary R. "Glucocorticoids and angiogenesis." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29367.
Full textCunha, Filipa. "Controlling angiogenesis electrically?" Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232613.
Full textJärvenpää, J. (Jouko). "Placental angiogenesis and angiogenesis related risk factors in severe pre-eclampsia." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288760.
Full textSköldenberg, Erik. "Angiogenesis in childhood malignancies." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3481.
Full textAngiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors.
In 33 patients with Wilms’ tumor, tumor capillaries were quantified, expression of angiogenic growth factors in tumor tissue investigated, and concentrations of angiogenic growth factors in serum measured. Reference values for angiogenic growth factors were obtained in 80 healthy adults (fibroblast growth factor 2 [FGF-2], vascular endothelial growth factor A [VEGF-A]) and 94 healthy children (angiogenin [ANG], epidermal growth factor [EGF], FGF-2, hepatocyte growth factor [HGF], tumor necrosis factor alpha [TNFA] and VEGF-A) aged 0.5-18 years. These reference values were compared with values in sera taken at diagnosis in 268 children with tumors and leukemias. CNB specimens were evaluated in 25 children with renal tumors.
A large number of capillaries was an independent prognostic factor for a poor outcome in Wilms’ tumor. Angiogenic growth factors were expressed in Wilms’ tumor tissue, and elevated concentrations of HGF and VEGF-A were found in both benign and malignant tumors. HGF was increased in leukemia, and TNFA was increased in leukemia, lymphoma and neuroblastoma. CNB, which proved to be a safe procedure, had a sensitivity of 76%.
These studies have demonstrated that quantification of capillaries is a prognostic factor in Wilms’ tumor and that HGF, TNFA and VEGF-A are frequently elevated in sera from children with cancer. Quantification of capillaries in tumor tissue and of circulating angiogenic growth factors would therefore seem to be of clinical relevance in managing children with cancer.
Mellberg, Sofie. "Molecular Regulation of Angiogenesis." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9418.
Full textZetterberg, Eva. "Angiogenesis in myeloproliferative disorders /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-383-3/.
Full textSköldenberg, Erik. "Angiogenesis in childhood malignancies /." Uppsala : Institutionen för kirurgiska vetenskaper, Uppsala universitet, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3481.
Full textO'Brien, Timothy Stephen. "Angiogenesis in bladder cancer." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388846.
Full textChan, Hock Yee. "Studies on tumour angiogenesis." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299162.
Full textPeirsis, Pages Maria. "Anti-Angiogenesis in neuroblastoma." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529877.
Full textPatel, Neel. "Radionuclide imaging of angiogenesis." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600030.
Full textFox, Stephen B. "Angiogenesis in human cancer." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:da4c4e35-7203-4efe-8716-109b5b1c4941.
Full textScott, A. "Modulators of retinal angiogenesis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1427875/.
Full textTrouillon, Raphael. "Electrochemical biosensors and angiogenesis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6120.
Full textElstow, S. F. "The angiogenesis factors of the eye and their relationship to tumour derived angiogenesis factors." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355902.
Full textJackson, Shaun William. "Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/9506.
Full textAngiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and promote metastasis, prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo.
Vitaliti, Alessandra. "Inhibition of tumor induced angiogenesis /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13409.
Full textDixelius, Johan. "Endothelial differentiation and angiogenesis regulation." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3009.
Full textAngiogenesis can be defined as the formation of new blood vessels from pre-existing ones. Angiogenesis is required for development and maintenance of our vascular system and thus of fundamental importance to our existence. The endothelial cells that line the inside of the vessels de-differentiate, migrate, proliferate and re-differentiate during angiogenesis. Angiogenesis is tightly regulated, controlled by several angiogenic factors of various classes that promote angiogenesis but also by anti-angiogenic factors that counteract the effect of the pro-angiogenic factors. We have examined three factors involved in angiogenesis regulation, Vascular endotelial growth factor (VEGFR) -3, the matrix protein laminin-1 and the collagen XVIII derived fragment endostatin.
Five tyrosine phosphorylation sites in the cytoplasmic tail of VEGFR-3 were identified by phosphopeptide mapping (PPM). The data was confirmed by PPM using point-mutated receptors generated by site-directed mutagenesis.
Laminin-1 was found to promote angiogenesis in the chicken chorioallantoic membrane assay and in a synergistic fashion together with suboptimal levels of fibroblast growth factor 2 (FGF-2) in embryoid bodies. Laminin-1 also promoted endothelial tubular morphogenesis in vitro, and upregulated the expression of the endothelial differentiation marker Jagged-1.
Endostatin was shown to affect endothelial FGF-2-induced cell survival and morphogenesis. This was a result of direct binding to endothelial cells and induction of tyrosine phosphorylation of many proteins including the adaptor protein Shb. The apoptotic and morphogenic responses induced by endostatin was shown to be dependent on Shb. Further, endostatin inhibited endothelial migration and affected molecules implicated in migration. In particular, FGF-2 induced actin reorganization, and β-catenin regulation was modulated by endostatin.
Wahlquist, Hanna. "Hypoxia and Angiogenesis in IUGR." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9316.
Full textBACKGROUND: Intrauterine growth restriction (IUGR) is a condition where the infant fails to reach its genetic growth potential due to numerous factors. IUGR foetuses are associated with high perinatal mortality and morbidity. This study investigated if hypoxia might be involved during gestation, and whether if hypoxia may have an impact on the development of the placenta, through regulation of various angiogenic factors, such as HIF-1_, VEGF, PIGF, VEGFR-1 and CD31. METHOD: Each sample of placental tissue was stained by immunohistochemisty for HIF-1_, VEGF, PIGF, VEGFR-1 and CD31. The intensity of staining was graded and the difference between the normal term placentas and the IUGR term placentas were evaluated. RESULTS: HIF-1_ was found to be upregulated in the normal term placental tissue, and VEGFR-1 was found to be upregulated in the IUGR term placental tissue. The other antibodies did not show any significant difference and PIGF failed to show any positive staining. CONCLUSIONS: Further studies on hypoxia in IUGR would be beneficial.
Barendsz-Janson, A. F. "Predictive models of tumor angiogenesis." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8524.
Full textHellebrekers, Debby Maria Elisabeth Ida. "Epigenetic regulation of tumor angiogenesis." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=5612.
Full textBråkenhielm, Ebba. "Angiogenesis in obesity and cancer /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-578-6/.
Full textZhang, Li Lyna. "Mechanistic studies of endometrial angiogenesis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339028.
Full textMavrou, Athina. "Targeting angiogenesis in prostate cancer." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654119.
Full textBourghardt, Peebo Beatrice. "Angiogenesis from a new perspective." Doctoral thesis, Linköpings universitet, Oftalmiatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73137.
Full textBainbridge, James William Braithwaite. "Gene therapy for ocular angiogenesis." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409631.
Full textAhmed, Shahzada Khuram. "Angiogenesis in the nasal mucosa." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4032/.
Full textFerguson, Mary L. "Angiogenesis in human lung tumours." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:865de25c-1ac3-4a30-85fa-a9fc677bfcc2.
Full textChen, Wei. "Modelling of tumour-induced angiogenesis." Thesis, Northumbria University, 2015. http://nrl.northumbria.ac.uk/30235/.
Full textDennie, Joëlle 1970. "NMR imaging of tumor angiogenesis." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43595.
Full textIncludes bibliographical references (leaves 66-69).
Cancer remains a major medical problem accounting for over 500,000 deaths in the US annually. A common feature of most human tumors is their ability to induce the proliferation of new blood vessels, i.e. angiogenesis. Considerable evidence now exists which demonstrates that these tumor vessels are associated with a distinct range of morphological and physiological properties which are not present in normal tissue vasculature. Several studies now document that in a wide variety of tumor models, average tumor vessels have diameters two times those of normal tissue vessels. NMR techniques based on magnetic susceptibility mechanisms are sensitive to varying sizes of blood vessels. By using gradient echo (GE) and spin echo (SE) pulse sequences and different concentrations of an exogenous contrast agent, it is possible to determine the signal contribution from small versus large vessels by examining the change in T2 and T2* rates ([delta]R2 and [delta]R2*), i.e. the ratio of [delta]R2* to [delta]R2 increases with vessel size. This ratio provides an index for the average size of vessels within a voxel. The central goal of this research was to utilize such a tool in order to obtain a regional picture of the tumor vascular bed. Rats, inoculated with C6 glial cells, underwent an MR imaging series nineteen days after implantation, which comprised conventional SE and GE images prior to and following serial injections of an equilibrium iron oxide contrast agent (MION). Regions within the tumor and in the contralateral normal gray matter were identified. The change in the T2 rate and T2* rate ([delta]R2 and [delta]R2*) were calculated for each region. Since susceptibility contrast mechanisms designed to study the distribution of vessel sizes rely entirely on the compartmentalization of the contrast agent within the vasculature, the first set of experiments was designed to demonstrate the stability of MION to remain within the vasculature, despite the disruption in the blood brain barrier. The second experiments measured [delta]R2 and [delta]R2* as a function of contrast agent concentration and TE. The MR measurements were compared with predicted values of [delta]R2 and [delta]R2* made from histological assessment of vessel sizes and theoretical Monte Carlo simulation results. The steady state measurements of [delta]R2 and [delta]R2* in the first experiments demonstrated that once the maximum contrast agent concentration had been reached, the values of [delta]R2 and [delta]R2* remained stable over 90 minutes, suggesting that MION remains within the vasculature. In the second experiments, significant differences were observed between the tumor and contralateral deep gray matter. Specifically, the ratio of ([delta] R2*/ ([delta]R2 was greater in the tumor than the normal brain, by a factor of 1.9 ± 0.2. From histologic sections and numerical simulations, the corresponding ratio was predicted to be 1.9 ± 0.1. These ratios are suggestive of a greater relative density of large vs small vessels. Maps of the ratio [delta]R2*/[delta]R2 were also produced on a pixel by pixel basis. Regions of high intensity on these maps (indicating a higher ratio of [delta]R2*/[delta]R2) corresponded well with the location of the tumor as determined using conventional images.
by Joëlle Dennie.
S.M.
Parsonson, Louis. "Modelling angiogenesis in three dimensions." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/29075/.
Full textYi, Ming. "Extracellular matrix proteins and angiogenesis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3091204.
Full textÅkerman, Maria E. "Targeting and inhibiting tumor angiogenesis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3166405.
Full textZhao, Yang. "Novel Regulators of Tumour Angiogenesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15496.
Full textTwomey, Catherine T. "Novel cytoskeletal regulators of angiogenesis." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742988.
Full textAxelsson, Hans. "Prostaglandins and angiogenesis in experimental cancer /." Göteborg : Department of Surgery, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, 2010. http://hdl.handle.net/2077/21933.
Full textCabrerizo, Granados David 1993. "Endothelial Snail1 in angiogenesis and tumorigenesis." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670305.
Full textSnail1 es un factor de transcripción con gran relevancia en el desarrollo tumoral, siendo necesario para la transición epitelio-mesénquima y la activación de fibroblastos asociados al cáncer (CAF). En esta tesis, hemos reportado la expresión de Snail1 en células endoteliales de tumor, jugando un papel fundamental en angiogénesis, promoviendo su migración, invasión y tubulogenesis in vitro. Estas funciones están asociadas a la inducción de Snail1 por FGF2 y VEGF-A, que generan un cambio en el perfil de expresión génica en las células endoteliales y modulan su estado de activación. La depleción específica de Snail1 en el endotelio de ratones adultos no supone un cambio fenotípico evidente; sin embargo, sí controla la angiogénesis y la morfología de los vasos en ensayos de plugs de Matrigel. Además, la eliminación específica de Snail1 en el endotelio del modelo murino de tumores de mama espontáneos MMTV-PyMT provoca el retraso en la iniciación de tumores, siendo éstos menos avanzados y con una morfología papilar. Estos efectos in vivo están asociados a la incapacidad de las células endoteliales sin Snail1 de promover una activación completa de fibroblastos in vitro e in vivo, debido a una señalización reducida de las vías de FGF2 y CXCL12; ni de generar una angiogénesis completa in vivo, con neovasos más anchos y menos invasivos. Cambios similares en la aparición de tumores y en su morfología se observaron en ratones MMTV-PyMT pretratados con el antiangiógenico bevacizumab. En muestras humanas de cáncer de mama pudimos recapitular la mayoría de los descubrimientos de los modelos animales usados. En resumen, estos hallazgos establecen un nuevo papel para Snail1 en las células endoteliales, no solo en angiogénesis, sino también en la aparición tumoral, el desarrollo y el fenotipo del tumor.
Powolny, Anna Aleksandra. "Diet, nutrition and prostate cancer angiogenesis." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1148992965.
Full textMurohara, Toyoaki. "Angiogenesis and vasculogenesis for therapeutic neovascularization." Nagoya University School of Medicine, 2003. http://hdl.handle.net/2237/5392.
Full textMarsh, Howard Piers. "Genetic polymorphisms in bladder cancer angiogenesis." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428513.
Full textSutton, Christopher Derek. "Angiogenesis in resected colorectal liver metastases." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29870.
Full textLichtenbeld, Hera Henrica Corine. "Tumor angiogenesis: an in vitro study." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6017.
Full textBeijnum, Judith Rosina van. "Gene expression profiling of tumor angiogenesis." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 2006. http://arno.unimaas.nl/show.cgi?fid=7710.
Full textLevchenko, Tetyana. "The role of angiomotin in angiogenesis /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-761-4/.
Full textVeitonmäki, Niina. "Angiostatic mechanisms of endogenous angiogenesis inhibitors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-555-7/.
Full textHillen, Femke. "Tumor cell plasticity: vascularisation beyond angiogenesis." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=9514.
Full textSluimer, Judith Christina. "Hypoxia, HIF and angiogenesis in atherosclerosis." Maastricht : Maastricht : Universitaire pers Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=10707.
Full textFawcett, Jonathan. "Molecular aspects of angiogenesis and metastasis." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386753.
Full textDuncan, Timothy Jake. "Immunoediting and angiogenesis in ovarian cancer." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11326/.
Full text