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1

Hennemuth, Anja, Leonid Goubergrits, Matthias Ivantsits, and Jan-Martin Kuhnigk, eds. Cerebral Aneurysm Detection. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-72862-5.

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2

Conan, Doyle A. Complete Sherlock Holmes & other detective stories. London: HarperCollins Publishers, 1994.

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3

Goobie, Beth. Before wings. London: Faber, 2008.

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4

Conan, Doyle A. A study in scarlet: The hound of the Baskervilles. London: Reader's Digest, 1991.

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5

Conan, Doyle A. A study in scarlet: The hound of the Baskervilles. London: Reader's Digest Association, 1991.

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6

Conan, Doyle A. A study in scarlet: The hound of the Baskervilles. London: Reader's Digest Association, 1993.

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7

Conan, Doyle A. A Study in Scarlet | The Hound of the Baskervilles. Pleasantville, N.Y., USA: Reader's Digest Association, 1986.

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8

Conan, Doyle A. Sherlock Holmes: The complete illustrated novels. London: Chancellor Press, 2001.

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9

Klinger, Leslie S., ed. Sherlock Holmes anotado: Las Novelas. Spain: Akal, 2009.

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10

Conan, Doyle A. Sherlock Holmes: The novels. London, England: Prion, 2008.

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11

Conan, Doyle A. The complete Sherlock Holmes long stories: A Study in scarlet ; The Sign of four ; The Hound of the Baskervilles ; The Valley of fear. London: Guild Publishing, 1988.

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12

Conan, Doyle A. Sherlock Holmes four great novels. London: Magpie, 1995.

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13

Conan, Doyle A. Sherlock Holmes: The Complete Illustrated Novels. London: Chancellor Press, 1989.

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14

Conan, Doyle A. The Sherlock Holmes Novels. New York: Quality Paperback Book Club, 2006.

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15

Conan, Doyle A. The new annotated Sherlock Holmes: The novels. New York: W. W. Norton, 2006.

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16

Conan, Doyle A. Tales of Sherlock Holmes. Toronto, Canada: CIHM, 1995.

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17

Conan, Doyle A. The best of Sherlock Holmes. London: J.M. Dent, 1992.

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18

Conan, Doyle A. Eine Studie in Scharlachrot. Frankfurt am Main: Insel, 2007.

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19

Conan, Doyle A. A Study in Scarlet. London, England: Penguin Books, 1988.

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20

Ivantsits, Matthias. Cerebral Aneurysm Detection: First Challenge, CADA 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 8, 2020, Proceedings. Springer International Publishing AG, 2021.

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21

de Graaf, Michiel A., Arthur JHA Scholte, Lucia Kroft, and Jeroen J. Bax. Computed tomography angiography and other applications of computed tomography. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0022.

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Patients presenting with acute chest pain constitute a common and important diagnostic challenge. This has increased interest in using computed tomography for non-invasive visualization of coronary artery disease in patients presenting with acute chest pain to the emergency department; particularly the subset of patients who are suspected of having an acute coronary syndrome, but without typical electrocardiographic changes and with normal troponin levels at presentation. As a result of rapid developments in coronary computed tomography angiography technology, high diagnostic accuracies for excluding coronary artery disease can be obtained. It has been shown that these patients can be discharged safely. The accuracy for detecting a significant coronary artery stenosis is also high, but the presence of coronary artery atherosclerosis or stenosis does not imply necessarily that the cause of the chest pain is related to coronary artery disease. Moreover, the non-invasive detection of coronary artery disease by computed tomography has been shown to be related with an increased use of subsequent invasive coronary angiography and revascularization, and further studies are needed to define which patients benefit from invasive evaluation following coronary computed tomography angiography. Conversely, the implementation of coronary computed tomography angiography can significantly reduce the length of hospital stay, with a significant cost reduction. Additionally, computed tomography is an excellent modality in patients whose symptoms suggest other causes of acute chest pain such as aortic aneurysm, aortic dissection, or pulmonary embolism. Furthermore, the acquisition of the coronary arteries, thoracic aorta, and pulmonary arteries in a single computed tomography examination is feasible, allowing ‘triple rule-out’ (exclusion of aortic dissection, pulmonary embolism, and coronary artery disease). Finally, other applications, such as the evaluation of coronary artery plaque composition, myocardial function and perfusion, or fractional flow reserve, are currently being developed and may also become valuable in the setting of acute chest pain in the future.
22

de Graaf, Michiel A., Arthur JHA Scholte, Lucia Kroft, and Jeroen J. Bax. Computed tomography angiography and other applications of computed tomography. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0022_update_001.

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Patients presenting with acute chest pain constitute a common and important diagnostic challenge. This has increased interest in using computed tomography for non-invasive visualization of coronary artery disease in patients presenting with acute chest pain to the emergency department; particularly the subset of patients who are suspected of having an acute coronary syndrome, but without typical electrocardiographic changes and with normal troponin levels at presentation. As a result of rapid developments in coronary computed tomography angiography technology, high diagnostic accuracies for excluding coronary artery disease can be obtained. It has been shown that these patients can be discharged safely. The accuracy for detecting a significant coronary artery stenosis is also high, but the presence of coronary artery atherosclerosis or stenosis does not imply necessarily that the cause of the chest pain is related to coronary artery disease. Moreover, the non-invasive detection of coronary artery disease by computed tomography has been shown to be related with an increased use of subsequent invasive coronary angiography and revascularization, and further studies are needed to define which patients benefit from invasive evaluation following coronary computed tomography angiography. Conversely, the implementation of coronary computed tomography angiography can significantly reduce the length of hospital stay, with a significant cost reduction. Additionally, computed tomography is an excellent modality in patients whose symptoms suggest other causes of acute chest pain such as aortic aneurysm, aortic dissection, or pulmonary embolism. Furthermore, the acquisition of the coronary arteries, thoracic aorta, and pulmonary arteries in a single computed tomography examination is feasible, allowing ‘triple rule-out’ (exclusion of aortic dissection, pulmonary embolism, and coronary artery disease). Finally, other applications, such as the evaluation of coronary artery plaque composition, myocardial function and perfusion, or fractional flow reserve, are currently being developed and may also become valuable in the setting of acute chest pain in the future.
23

de Graaf, Michiel A., Arthur JHA Scholte, Lucia Kroft, and Jeroen J. Bax. Computed tomography angiography and other applications of computed tomography. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199687039.003.0022_update_002.

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Patients presenting with acute chest pain constitute a common and important diagnostic challenge. This has increased interest in using computed tomography for non-invasive visualization of coronary artery disease in patients presenting with acute chest pain to the emergency department; particularly the subset of patients who are suspected of having an acute coronary syndrome, but without typical electrocardiographic changes and with normal troponin levels at presentation. As a result of rapid developments in coronary computed tomography angiography technology, high diagnostic accuracies for excluding coronary artery disease can be obtained. It has been shown that these patients can be discharged safely. The accuracy for detecting a significant coronary artery stenosis is also high, but the presence of coronary artery atherosclerosis or stenosis does not imply necessarily that the cause of the chest pain is related to coronary artery disease. Moreover, the non-invasive detection of coronary artery disease by computed tomography has been shown to be related with an increased use of subsequent invasive coronary angiography and revascularization, and further studies are needed to define which patients benefit from invasive evaluation following coronary computed tomography angiography. Conversely, the implementation of coronary computed tomography angiography can significantly reduce the length of hospital stay, with a significant cost reduction. Additionally, computed tomography is an excellent modality in patients whose symptoms suggest other causes of acute chest pain such as aortic aneurysm, aortic dissection, or pulmonary embolism. Furthermore, the acquisition of the coronary arteries, thoracic aorta, and pulmonary arteries in a single computed tomography examination is feasible, allowing ‘triple rule-out’ (exclusion of aortic dissection, pulmonary embolism, and coronary artery disease). Finally, other applications, such as the evaluation of coronary artery plaque composition, myocardial function and perfusion, or fractional flow reserve, are currently being developed and may also become valuable in the setting of acute chest pain in the future.
24

de Graaf, Michiel A., Arthur JHA Scholte, Lucia Kroft, and Jeroen J. Bax. Computed tomography angiography and other applications of computed tomography. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0022_update_003.

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Patients presenting with acute chest pain constitute a common and important diagnostic challenge. This has increased interest in using computed tomography for non-invasive visualization of coronary artery disease in patients presenting with acute chest pain to the emergency department; particularly the subset of patients who are suspected of having an acute coronary syndrome, but without typical electrocardiographic changes and with normal troponin levels at presentation. As a result of rapid developments in coronary computed tomography angiography technology, high diagnostic accuracies for excluding coronary artery disease can be obtained. It has been shown that these patients can be discharged safely. The accuracy for detecting a significant coronary artery stenosis is also high, but the presence of coronary artery atherosclerosis or stenosis does not imply necessarily that the cause of the chest pain is related to coronary artery disease. Moreover, the non-invasive detection of coronary artery disease by computed tomography has been shown to be related with an increased use of subsequent invasive coronary angiography and revascularization, and further studies are needed to define which patients benefit from invasive evaluation following coronary computed tomography angiography. Conversely, the implementation of coronary computed tomography angiography can significantly reduce the length of hospital stay, with a significant cost reduction. Additionally, computed tomography is an excellent modality in patients whose symptoms suggest other causes of acute chest pain such as aortic aneurysm, aortic dissection, or pulmonary embolism. Furthermore, the acquisition of the coronary arteries, thoracic aorta, and pulmonary arteries in a single computed tomography examination is feasible, allowing ‘triple rule-out’ (exclusion of aortic dissection, pulmonary embolism, and coronary artery disease). Finally, other applications, such as the evaluation of coronary artery plaque composition, myocardial function and perfusion, or fractional flow reserve, are currently being developed and may also become valuable in the setting of acute chest pain in the future.
25

Galiuto, L., R. Senior, and H. Becher. Contrast echocardiography. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0007.

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Contrast echocardiography is a non-invasive, well tolerated echocardiographic technique which employs ultrasound contrast agent in order to improve the quality of echocardiographic images, by enhancing blood flow signal.Clinical usefulness of this echocardiographic imaging modality resides in the possibility of providing better acoustic signal in cases of poor quality images, with additional important information related to assessment of myocardial perfusion. Indeed, about one-third of echocardiographic images are affected by poor quality due to high acoustic impedance of the chest wall of the patients secondary to obesity or pulmonary diseases, not allowing detection of left ventricular endocardial border. Moreover, in patients with low ejection fraction and apical left ventricular aneurysm, intraventricular thrombus could be undetectable with standard echocardiography. Furthermore, coronary microcirculation cannot be assessed by standard echocardiography. Contrast echocardiography can be performed in all such conditions to improve diagnostic power of echocardiography.The adjunctive role of contrast echocardiography is well defined in both rest and stress echocardiography in order to detect the endocardial border and intraventricular thrombi, to accurately measure ejection fraction, wall motion, and to assess myocardial perfusion.The purpose of this chapter is to explain basic principles, feasibility, safety, major clinical applications, current indications, and further developments of contrast echocardiography.
26

Rao, Chethan P. Venkatasubba, and Jose Ignacio Suarez. Management of non-traumatic subarachnoid haemorrhage in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0239.

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Non-traumatic subarachnoid haemorrhage (ntSAH) is a complex disease affecting multiple systems and the hospital course of affected patients can be variable. ntSAH is associated with high morbidity and mortality, with the causes of early deaths being either rebleeding or hydrocephalus. The risk of rebleeding is reduced by immediate control of arterial blood pressure and early securing of ruptured aneurysms by either endovascular coiling or surgical clipping. Ongoing management focuses on prevention, detection, and management of delayed neurological deficits. Current recommendations include prophylactic use of nimodipine, maintenance of hypertension and euvolaemia or hypervolaemia, and endovascular treatment of vasospasm that fails to respond to medical therapy. Systemic complications following ntSAH include myocardial injury, acute lung injury, venous and pulmonary thromboembolism, fluid and electrolyte abnormalities, and severe sepsis. Each of these complications should be treated on its merits. Due to the complexity of management patients with ntSAH should be treated in a critical care environment by a collaborative team of neurosurgeons, neuroradiologists, neurologists and intensivists.
27

Banerjee, Amitava, and Kaleab Asrress. Screening for cardiovascular disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0351.

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Screening involves testing asymptomatic individuals who have risk factors, or individuals who are in the early stages of a disease, in order to decide whether further investigation, clinical intervention, or treatment is warranted. Therefore, screening is classically a primary prevention strategy which aims to capture disease early in its course, but it can also involve secondary prevention in individuals with established disease. In the words of Geoffrey Rose, screening is a ‘population’ strategy. Examples of screening programmes are blood pressure monitoring in primary care to screen for hypertension, and ultrasound examination to screen for abdominal aortic aneurysm. The effectiveness and feasibility of screening are influenced by several factors. First, the diagnostic accuracy of the screening test in question is crucial. For example, exercise ECG testing, although widely used, is not recommended in investigation of chest pain in current National Institute for Health and Care Excellence guidelines, due to its low sensitivity and specificity in the detection of coronary artery disease. Moreover, exercise ECG testing has even lower diagnostic accuracy in asymptomatic patients with coronary artery disease. Second, physical and financial resources influence the decision to screen. For example, the cost and the effectiveness of CT coronary angiography and other new imaging modalities to assess coronary vasculature must be weighed against the cost of existing investigations (e.g. coronary angiography) and the need for new equipment and staff training and recruitment. Finally, the safety of the investigation is an important factor, and patient preferences and physician preferences should be taken into consideration. However, while non-invasive screening examinations are preferable from the point of view of patients and clinicians, sometimes invasive screening tests may be required at a later stage in order to give a definitive diagnosis (e.g. pressure wire studies to measure fractional flow reserve in a coronary artery). The WHO’s principles of screening, first formulated in 1968, are still very relevant today. Decision analysis has led to ‘pathways’ which guide investigation and treatment within screening programmes. There is increasing recognition that there are shared risk factors and shared preventive and treatment strategies for vascular disease, regardless of arterial territory. The concept of ‘vascular medicine’ has gained credence, leading to opportunistic screening in other vascular territories if an individual presents with disease in one territory. For example, post-myocardial infarction patients have higher incidence of cerebrovascular and peripheral arterial disease, so carotid duplex scanning and measurement of the ankle–brachial pressure index may be valid screening approaches for arterial disease in other territories.
28

Conan, Doyle A. Study in Scarlet Illustrated: Fiction, Mystery and Detective. Independently Published, 2021.

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29

Conan, Doyle A. Complete Detective Stories of Conan Doyle (Collins Classics). Collins, 1994.

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30

A Study in Scarlet / The Hound of the Baskervilles. London: Reader's Digest Association Limited, 1990.

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31

Conan, Doyle A. The New Annotated Sherlock Holmes, Volume 3: The Novels (A Study in Scarlet, The Sign of Four, The Hound of the Baskervilles, The Valley of Fear) (non-slipcased edition). W. W. Norton, 2007.

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32

Hutchinson, George, Doyle A. Conan, and Sidney Paget. Complete Illustrated Novels of Sherlock Holmes: A Study in Scarlet, the Sign of the Four, the Hound of the Baskervilles and the Valley of Fear (Enga. Engage Books, 2011.

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33

Sir Arthur Conan Doyle The Complete Sherlock Holmes. Collector's Library, 2011.

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34

Conan, Doyle A. Sherlock Holmes Novels. Bounty Books, 2006.

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35

Conan, Doyle A. Sherlock Holmes: The Four Long Stories (Twelve-Point Series). North Books, 1998.

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36

Conan, Doyle A. Sherlock Holmes: The Complete Illustrated Novels. Chancellor Press, 2002.

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37

Conan, Doyle A. Sherlock Holmes: The Ultimate Collection. Lulu.com, 2016.

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38

Conan, Doyle A. The Complete Long Stories of Shelock Holmes. Jaico Publishing House, 2005.

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39

Hutchinson, George, Doyle A. Conan, and Sidney Paget. Complete Illustrated Novels of Sherlock Holmes: A Study in Scarlet, the Sign of the Four, the Hound of the Baskervilles and the Valley of Fear (Enga. Engage Books, 2012.

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40

Conan, Doyle A. Sherlock Holmes: The Four Long Stories. North Books, 1995.

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41

Paget, Sidney. Complete Illustrated Novels of Sherlock Holmes: With 37 Short Stories. AD Classic, 2014.

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42

Conan, Doyle A. The Complete Sherlock Holmes Novels - Unabridged - A Study in Scarlet, the Sign of the Four, the Hound of the Baskervilles, the Valley of Fear. Benediction Classics, 2012.

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43

Publications, World, and Doyle A. Conan. Sherlock Holmes: Four Great Novels (Works). World Publications (MA), 1998.

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44

Conan, Doyle A. Sherlock Holmes: The Complete Illustrated Novels. Chancellor Press, 2004.

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45

Sherlock Holmes: The Long Stories. Leicester: Galley Press, 1987.

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46

Paget, Sidney. Complete Illustrated Novels of Sherlock Holmes: With 37 Short Stories. AD Classic, 2014.

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47

The Complete Sherlock Holmes Long Stories. London: Guild Publishing, 1989.

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48

Sherlock Holmes: Tutti i romanzi. Torino, Italy: Einaudi, 2009.

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49

A Study In Scarlet. Viking, 2011.

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50

Conan, Doyle A. Conan Doyle's Stories for Boys. Kessinger Publishing, 2005.

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