Relevant bibliographies by topics / Andrographis paniculata

Academic literature on the topic 'Andrographis paniculata'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Andrographis paniculata"

Dewi, Indri Kusuma, Titik Lestari, and Siti Nur Rofi'ah. "Formulation and Physical Test of Ethanolic Extract Sambiloto Leaves (Andrographis paniculata) Ointment." Sains Medika 6, no. 2 (January 4, 2016): 56. http://dx.doi.org/10.26532/sainsmed.v6i2.603.

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Introduction: Andrographis paniculata had known contained active substance such as andrographolida, atsiri oil, flavonoid, tannin, alkaloid, and saponin which functions as antibacterial, antitoxic, analgesic, and anti-pyretic. Based on its antibacterial properties, an ointment form of Andrographis paniculata leaf is then formulated, for practical usage. Ointment formula is semi solid for topical use in the skin or mucosal membranes. Objectives: to know the result of ointment physical test of etanolic extract Andrographis paniculata leaf. Methods: physical tests contain organoleptic test, pH, homogenity, adhesion test and dispersive test. Results: Ointment shaped semi solid, blacky green and special smell of Andrographis paniculata, pH 6, homogenity test obtained homogenous results, adhesion test was 82 second and dispersive test was 5.6 cm. Conclusion: the result of physical tests of etanolic Andrographis paniculata leaf extract ointment appropriate with quality standard.

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Agrawal, Dr R. C., and Prachi Pandey. "SCREENING OF Andrographis Paniculata EXTRACT FOR ANTIOXIDANT AND GENOTOXIC ACTIVITIES." International Journal of Research -GRANTHAALAYAH 7, no. 6 (June 30, 2019): 132–42. http://dx.doi.org/10.29121/granthaalayah.v7.i6.2019.780.

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Andrographis paniculata is an important medicinal plant which has been used to treat various ailments. The present study was undertaken to analyze the phytochemical compounds and evaluated the antioxidant and genotoxic potential of Andrographis paniculata leaves and whole plant extracts. Phytochemical compounds analyzed by qualitative and quantitative analysis of methanol extracts of the leaves and whole plant extracts which showed the presence of Alkaloids, Carbohydrate, Resins, Saponins, Flavonoid, Steroids, Glycosides and Tannin. Quantitative analysis were also conducted to determine the amount of Alkaloids, Flavonoids, Saponins and Tannin by HPTLC Finger printing methods in A. paniculata ( A.P.) leaves and whole plant .The Antioxidant activity of A. paniculata Methanolic extract was evaluated by Fenton methods which showed the dose dependent Inhibition of TBARS formation. The Genotoxicity was evaluated by Micronucleus Assay. The dose dependent prevention of bone marrow micronucleus formation by Andrographis paniculata leaves and whole plant extracts was observed. Therefore, Andrographis paniculata leaves and whole plant extract caused antioxidant and genotoxic potential.

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Sahu, Madhavi, and S. Prakash Rao. "Review Literature: Andrographis paniculata." Research Journal of Pharmacology and Pharmacodynamics 10, no. 4 (2018): 166. http://dx.doi.org/10.5958/2321-5836.2018.00031.9.

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Sadhana H M, Suresh Joghee, and Hamsalakshmi. "Andrographis Paniculata – A Review." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (September 25, 2020): 5395–400. http://dx.doi.org/10.26452/ijrps.v11i4.3162.

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Andrographis paniculata (AP) is commonly known as creat or green chiretta belongs to the family Acanthaceae. It is also known as Kalmegh and popularly called as King of bitters. It was widely used in the traditional system of medicines such as Siddha system, Ayurvedic system and Chinese medicine for the regular treatment of a common cold. Some of the reported health benefits are Antidiabetic, Antipyretic, Hepatoprotective, Antioxidant, Antimalarial, Anti-cancer, Antityphoid, Anti-diarrhoea, antioedema, etc. Whole plant possesses medicinal property and leaves are explicitly used for therapeutic care. The plant contains four major diterpenoids such as andrographolide, neoandrographolide,14-deoxyandrographolide, 14-deoxy-11,12-didehydroandrographolide and also includes other phytoconstituents such as flavonoidssesquiterpene lactones, etc. Andrographolide is found as major constituent in the leaves and reported for a wide variety of pharmacological activities. The purpose of this review is to brief the plant's literature survey via internet sources such as google scholar and PubMed providing a medium to explain the plant's ethnobotany information on conventional usage, essential chemical constituents and selected plant pharmacology activities are obtained from existing research articles to frame the review. The present analysis also illustrates the pharmacological and phytochemical characteristics of Andrographis paniculata from which researchers may get benefited for further qualitative research.

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KUROYANAGI, MASANORI, MAKOTO SATO, AKIRA UENO, and KOUZABURO NISHI. "Flavonoids from Andrographis paniculata." CHEMICAL & PHARMACEUTICAL BULLETIN 35, no. 11 (1987): 4429–35. http://dx.doi.org/10.1248/cpb.35.4429.

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Fitriani, Nyayu, Kamalia Layal, and Kamila Kamila. "Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Andrographis Paniculata dan Vernonia Amygdalina." Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan 7, no. 2 (March 2, 2017): 104. http://dx.doi.org/10.32502/sm.v7i2.1371.

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Diabetes mellitus merupakan sekelompok penyakit metabolik yang ditandai dengan hiperglikemia kronik yang diakibatkan oleh defek pada sekresi insulin, aksi insulin atau keduanya. Daun Andrographis paniculata dan Vernonia amygdalina merupakan tanaman yang dapat digunakan sebagai pengendali kadar gula dalam darah. Penelitian ini bertujuan untuk mengetahui efektivitas kombinasi ekstrak kedua daun dibandingkan dengan acarbose dalam menurunkan kadar gula darah postprandial tikus diabetes. Penelitian ini adalah penelitian eksperimental, dengan pre dan post test control group design. Tikus diinduksi dengan aloksan kemudian diobati dengan kombinasi ekstrak dengan dosis yang berbeda selama 7 hari. Sebanyak 25 ekor tikus dibagi dalam 5 kelompok, yaitu kelompok yang diberikan aquadest (kontrol negatif); acarbose 75mg/kgBB (kontrol positif), kombinasi ekstrak etanol daun Andrographis paniculata 500mg/kgBB dan daun Vernonia amygdalina 100mg/kgBB; kombinasi ekstrak etanol daun Andrographis paniculata 1000mg/kgBB dan daun Vernonia amygdalina 200mg/kgBB; dan kombinasi ekstrak etanol daun Andrographis paniculata 2000mg/kgBB dan daun Vernonia amygdalina 400mg/kgBB. Analisis data kadar gula darah tikus menggunakan uji T- berpasangan dan PostHoc. Hasil penelitian didapatkan bahwa tidak terdapat perbedaan bermakna antara semua kombinasi ekstrak daun Andrographis paniculata dan daun Vernonia amygdalina dengan acarbose dalam menurunkan kadar gula darah postprandial tikus wistar yang diinduksi aloksan (p>0,05). Dari penelitian ini dapat disimpulkan bahwa kombinasi ekstrak etanol daun Andrographis paniculata dan daun Vernonia amygdalina efektif dalam menurunkan kadar gula darah postprandial tikus diabetes.

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Oseni, B. A., C. P. Azubuike, and O. O. Okubanjo. "DNA Barcode Authentication and Improvement of Andrographolide Yield in Andrographis paniculata Plant." Nigerian Journal of Pharmaceutical Research 16, no. 2 (January 19, 2021): 117–25. http://dx.doi.org/10.4314/njpr.v16i2.3.

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Background: Andrographolide, the major bioactive compound responsible for most pharmacological activities such as anticancer, antimicrobial activity exhibited by the Andrographis paniculata plant is present in small quantities. In addition, the genus Andrographis has about 28 species most of which possess no medicinal value. The deoxyribonucleic acid (DNA) barcode is utilized in species identification and plant authentication.Objectives: This study aimed at authenticating Andrographis paniculata using DNA barcodes and improving the yield of andrographolide via enzymatic treatment.Materials and Method: The DNA of Andrographis plant was obtained using the Qiagen kit. The psbA-trnH and rbcL DNA barcode regions were amplified using polymerase chain reaction (PCR). Presence of amplified regions was confirmed using gel electrophoresis and the amplicons were sequenced. A blast N search was performed on the sequenced DNA. The constituents of A. paniculata dried leaves was extracted using methanol, followed by treatment with and without β glucosidase. The extract obtained was dried and partitioned using ethyl acetate. The ethyl acetate fraction was concentrated and dissolved in methanol. Andrographolide content was determined using high performance liquid chromatography (HPLC).Results: The psbA-trnH and rbcL DNA regions were successfully amplified having 358 and 604 bp respectively. The DNA barcode sequences obtained were identical to the psbA-trnH (97%) and rbcL (99%) genes of A. paniculata voucher MICET P00101. The mean andrographolide yield was 9.4±0.11mg/g and 8.9±0.13mg/g dry weight for the treatment and control groups respectively; statistical analysis at p = 0.05 shows a significant difference.Conclusion: The Andrographis plant used in this study was confirmed to be Andrographis paniculata, enzymatic treatment increased andrographolide yield from the plant. Keywords: Andrographis paniculata, andrographolide, authentication, DNA barcodes, β-glucosidase.

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Ain, Noor ul, Nusrat Bano, Anwar Ejaz Beg, Kamran Hameed, Talha Bin Fayyaz, and Rafia Sadaf. "HEMATOLOGICAL TOXICITY IN RATS;." Professional Medical Journal 24, no. 02 (February 14, 2017): 342–46. http://dx.doi.org/10.29309/tpmj/2017.24.02.525.

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Objectives: Oxaliplatin causes hematological toxicities in clinical setting whichlimits its efficacy. The aim of this study is to investigate the therapeutic effects of Andrographispaniculata against hematological toxicity caused by oxaliplatin. Study design: Experimentalanimal study. Period: Study takes 8 month from March 2015 to Oct 2015. Setting: Dow universityanimal house. Method: Wistar albino male rats, divided into 3 equals groups (n=6): GroupN* was a control group (0.9% normal saline), Group NP0 was Oxaliplatin treated group andGroup NP1 was prophylactically treated with Andrographis paniculata followed by Oxaliplatinin order to assess the protective effects of Andrographis paniculata against the hematologictoxicity caused by Oxaliplatin. Results: Prophylactic treatment with Andrographis paniculata(NP1) significantly increases the levels of platelets and neutrophile count compared with thestandard (NP0) (p<0.01) and increases the RBCs count and levels of hemoglobin comparedwith the standard (NP0). Conclusion: Prophylactic treatment with Andrographis paniculata(NP1) was effective in reducing risk of thrombocytopenia, anemia and neutropenia associatedwith Oxaliplatin.

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Roy, Anitha. "Molecular docking analysis of compounds from Andrographis paniculata with EGFR." Bioinformation 17, no. 1 (January 31, 2021): 23–28. http://dx.doi.org/10.6026/97320630017023.

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EGFR is linked with oral cancer. Therefore, it is of interest document the molecular docking analysis of compounds from Andrographis paniculata with EGFR. We report the binding features of five compounds 14- acetylandrographolide, andrograpanin, andrographolide, isoandrographolide and neoandrographolide from Andrographis paniculata with EGFR for further consideration.

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Sharma, Kriti, and Ekta S. Chauhan. "Comparative Study of Nutritional and Phytochemical Attributes of Andrographis paniculata, Bryophyllum pinnatum and Clitoria ternatea for Nutraceutical Applications." Current Nutrition & Food Science 15, no. 6 (September 18, 2019): 600–607. http://dx.doi.org/10.2174/1573401314666181024144113.

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Background:Andrographis paniculata, Bryophyllum pinnatum and Clitoria ternatea are the nutritionally adequate herbs that are easily accessible and low cost. The presence of phytochemicals makes them helpful in the management of various diseases specifically being diabetes, anemia and hypertension leading to prevention of heart diseases.Objective:Current investigation is aimed to determine the nutritional and phytochemical composition of leaves of Andrographis paniculata, Bryophyllum pinnatum and Clitoria ternatea.Methods:All the experiments were done according to standard procedures of the Association of Analytical Communities (AOAC).Results:Leaves of Clitoria ternatea were recorded to have a maximum concentration of vitamin C, compared to Andrographis paniculata and Bryophyllum pinnatum. Simultaneously, carbohydrate content was also recorded to be maximum and found significantly higher (p<0.05) as compared to Andrographis paniculata and Bryophyllum pinnatum. Leaves of Andrographis paniculata were found to have maximum contents of ash, manganese, calcium, sodium and iron which were also significantly higher (P<0.05) as compared to Bryophyllum pinnatum and Clitoria ternatea. Levels of potassium, magnesium and phosphorus were recorded maximum in Bryophyllum pinnatum among the three herbs studied. Levels of alkaloids, flavonoids and tannins were recorded to be significantly elevated (P<0.05) in Clitoria ternatea among studied herbs. Meanwhile, saponins and phenolic compounds were found to be maximum in leaves of Bryophyllum pinnatum and they were significantly elevated (P<0.05) as compared to Andrographis paniculata and Clitoria ternatea.Conclusion:Nutrients and phytoconstituents help to maintain nutritional status as well as prevent various disorders. Therefore, they should be included as a dietary supplement.

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Dissertations / Theses on the topic "Andrographis paniculata"

Xu, Youhong. "Adaptive immune response-modifying and antimicrobial properties of Andrographis paniculata and andrographolide." University of Southern Queensland, Faculty of Sciences, 2009. http://eprints.usq.edu.au/archive/00005134/.

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Andrographis paniculata (AP) is a traditional herbal medicine which is widely used for the treatment of many diseases in Asia. Recently, various biological activities of AP extract or andrographolide (AND), such as immunostimulatory activity, anti-inflammatoryeffect, cytokine induction or deduction, a potential cancer therapeutic agent and T cell activation suppression, have been reported. However the potential ofAP extract or AND to stimulate the specific or adaptive immune response using microbial vaccines has not been determined. In this project, AND has been purifiedfrom AP and its identity confirmed by the melting point, colour test, TLC, UV absorption spectrum, ESI-MS and H-NMR. An aqueous and two ethanolic extracts ofAndrographis paniculata and AND, an active principle of Andrographis paniculata, were investigated for their antimicrobial activity against nine bacterial species in vitro using the disc diffusion method. It was discovered that neither the aqueous extract nor AND were bacteriostatic or bactericidal against S. typhimurium, E. coli, S. sonnei, S. aureus, P. aeruginosa, S. pneumoniae, S. pyogenes, L. pneumophila or B. pertussisbut the two ethanolic extracts of AP were bacteriostatic against L. pneumophila and B. pertussis. It was also observed that the ethanol extract of AP and AND stimulatedboth antibody and cell-mediated immunity (CMI) responses to a killed S. typhimurium vaccine. Mice were vaccinated with either one dose or two doses of killed S. typhimurium vaccine. They were fed two different quantities of an ethanol extract of AP or AND for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both the extract and AND significantly increased the IgG antibody titres against S. typhimurium, with theincrease in antibody titres being statistically significant in the two dose vaccine group. Although not statistically significant, there was also a substantial increase in the IgG antibody titres in the one dose vaccine group. Splenocyte cultures from mice fromboth the immunisation groups treated with the extract or AND stimulated with the S. typhimurium lysate showed a significant increase in the production of IFN-γ in both14 and 28 day AP extract or AND treatment groups. The increase indicates the induction of a cell-mediated immune response. To confirm the immunomodulatory potential of AP extract and determine the immunomodulatory potential of AND, experiments were conducted using mouse salmonellosis as a model system. Mice were vaccinated with two doses of killed S. typhimurium vaccine by intraperitoneal(i/p) route and orally dosed with AP extract at 25 mg/kg bodyweight or AND at 4 mg/kg bodyweight for total 28 days, followed by oral challenge with virulent S. typhimurium. Both AP extract and AND substantially increased the survival rate by 50% after mice were challenged with 10 fold of a sublethal dose (1.5x10 6 cfu) of virulent S. typhimurium. They also promoted clearance of S. typhimurium from challenged mice by days 8 or 12 post-challenge with 1.5x10 cfu virulent S. typhimurium respectively. Sera IgG, IgA antibody titres against S. typhimurium and IFN-γ or IL-2 were detected after the mice were challenged by the oral route with a sublethal dose (1.5x10 cfu) of virulent S. typhimurium for 12 days. It was thus concluded that both Andrographis paniculata and AND not only elicited both humoral and cell-mediated immune responses in the mouse model, but also increasedthe protective efficacy against salmonellosis on mice vaccinated with inactivated S. typhimurium. Therefore the ability of Andrographis paniculata and AND to promoteacquired immunity, particularly in inducing CMI may be important in protection against intracellular pathogen infection.

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Wongkittipong, Rutchadaporn. "Development of andrographolide extraction process from andrographis paniculata nees in a pulsed column." Toulouse, INPT, 2004. http://www.theses.fr/2004INPT002G.

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Ce travail traite d'extraction solide-liquide à partir de matière végétale. Les caractéristiques (densité, taille des particules, porosité et forme) de l'andrographis paniculata nees, plante traditionnelle de Thai͏̈lande, ont été obtenues. L'extraction de l'andrographolide est étudiée en premier lieu en réacteur Batch. L'influence des conditions de fonctionnement sur la cinétique d'extraction a été étudiée. Des rendements de 70% et 90% ont été atteints pour des temps de 20 et 60 mn respectivement. Un modèle de ransfert de matière basé sur le modèle dit à deux formes est proposé. Un premier essai d'extraction solide-liquide utilisant un système de pulsation pneumatique a été réalisé dans un processus continu afin d'éviter l'engorgement de la colonne. La combinaison du modèle de diffusion avec le temps de séjour moyen permet de concevoir le processus continu. Finalement, un extudeur bi-vis a été utilisé pour comparer le rendement d'extraction avec celui de l'expérience réalisée en mode batch.

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Tipakorn, Naiyana. "Effects of Andrographis paniculata (Burm.F.) Nees on performance, mortality and coccidiosis in broiler chickens." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964912708.

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Mussard, Eugénie. "Andrographis paniculata et ses diterpènes labdanes contre le stress oxydant et l'inflammation dans le vieillissement cutané." Thesis, Orléans, 2019. http://www.theses.fr/2019ORLE3040.

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Avec l'âge et l'exposition à des facteurs environnementaux tels que les rayons solaires, la peau subit une usure naturelle. Elle se caractérise par l’apparition de rides, d’une perte d'élasticité, d’un relâchement et d’un aspect rugueux. Ce projet vise à explorer de nouveaux agents actifs anti-âges issus de la plante Andrographis paniculata (AP). AP est une plante médicinale utilisée en Asie pour traiter les infections respiratoires et diverses maladies inflammatoires. Cette plante est riche en diterpènes labdanes, dont son principal agent bioactif est l’andrographolide. Un extrait méthanolique des feuilles d’AP, l'andrographolide, la neoandrographolide, la 14-deoxyandrographolide et la 14-deoxy-11,12-didehydroandrographolide ont été utilisés dans une culture primaire de fibroblastes dermiques (HDFa) et une lignée cellulaire de kératinocytes (HaCaT). Pour l'étude du stress oxydant, ces cellules traitées dans des conditions pro-oxydantes ont révélé l'activité antioxydante de l'extrait méthanolique et de la 14-deoxyandrographolide. Dans des conditions pro-inflammatoires, l'expression du TNF-α a été diminuée par l'andrographolide et par l'extrait méthanolique dans les HDFa et par l’extrait méthanolique dans les HaCaT. L'andrographolide et l'extrait méthanolique ont également diminué la sécrétion d'IL-6 dans la HDFa dans des conditions inflammatoires. Enfin, la 14-désoxyandrographolide a réduit la production de procollagène de type I dans les HDFa. Nos données confirment leur potentiel régénérateur contre les dommages cutanés causés par le stress oxydant et l'inflammation. D'autres recherches sont nécessaires afin d’explorer ses voies
With age and exposure to environmental factors such as sunlight, the skin suffers natural wear and tear. It is characterized by development of wrinkles, loss of elasticity, laxity, and rough-textured appearance. The present project aims to explore new anti-aging active agents from Andrographis paniculata (AP) plant. AP is a medicinal plant used in Asia to treat respiratory infections and various inflammatory diseases. It is enriched in labdane diterpenes, including andrographolide, as its main bioactive agent. A methanolic extract from AP leaves, andrographolide, neoandrographolide, 14-deoxyandrographolide, and 14-deoxy-11,12-didehydroandrographolide were used in a primary culture of dermal fibroblasts (HDFa) and a keratinocyte cell line (HaCaT). For the oxidative stress study, HDFa and HaCaT treated under pro-oxidant conditions revealed the antioxidant activity of methanolic extract and 14-deoxyandrographolide. Under pro-inflammatory conditions, TNF-α expression was decreased in HDFa with andrographolide and methanolic extract, and in HaCaT with methanolic extract only. Andrographolide and methanolic extract also decreased IL-6 secretion in HDFa under inflammatory conditions. Finally, 14-deoxyandrographolide reduced the production of type I procollagen in HDFa. Our data confirm the AP potential skin damage regeneration induced by oxidative stress and inflammation. Further research is required to explore its pathways

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Pekthong, Dumrongsak. "Evaluation de possibles Interactions Médicamenteuses : Effets d’extraits de Andrographis paniculata sur les enzymes du métabolisme hépatique chez le rat et chez l’Homme." Besançon, 2008. http://www.theses.fr/2008BESA0006.

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Chua, Kui Hong, and kuihongchua@hotmail com. "Studies on Andrographis paniculata (Burm. f.) Nees (HDM 15) A Medicinal Native Plant of Brunei Darussalam." RMIT University. Health Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080703.112512.

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Ethno botanical surveys have revealed that Brunei Darussalam has a rich source of tropical medicinal plants. As 80% of the country's land is covered by tropical rainforest, Brunei Darussalam may have some medicinal plants with unique characteristics of secondary metabolites. Some plants such as Catharanthus roseus (L.) G. Don and Eurycoma longifolia Jack have long been used by the local communities to treat various disease conditions. However, no research has been done in terms of the constituents or biological activities of the Brunei Darussalam medicinal plants. We have investigated the genetic variability diversity and pharmacological actions of Andrographis paniculata (Burm.f.) Nees [1] also known as Daun Pahit or Chuan Xin Lian or King of Bitters by an interdisciplinary approach, involving DNA-based RAPD and RFLP analyses, HPLC-based chemical analysis as well as cell culture and tissue-based bioassays. We have demonstrated that Andrographis paniculata extr acts exhibited a range of actions including antioxidant, anti-allergies, anti-inflammatory and anti-cancer effects. Some of the pharmacological actions of Andrographis paniculata are co-related with their active constituents Andrographolide (A) and Dehydroandrographolide (D). The study is valued not only in obtaining experimental evidence for supporting traditional use of native medicinal plants but also in establishing a platform for studying other medicinal plants in Brunei Darussalam.

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Badhe, Pravin. "Characterisation of fractions from Andrographis paniculata and Silybum marianum plant extracts that protect human cells against DNA damage." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/14796.

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Plants have been utilized as a source of medicines since ancient times. They contain a vast range of secondary metabolites which play important roles in different diseases. The Scope of this study is to define the function of secondary metabolites from Andrographis paniculata (Kalmegh) and Silybum marianum (Milk Thistle) against DNA damage, which initiates many diseases. Sequential extraction of both plant materials was performed with different polarity solvents. Qualitative analysis was performed with Gas (GC) and High Performance Liquid Chromatography (HPLC). Primary extracts screening studies were performed against cytotoxicity, antioxidant and soluble collagen assays (Sircol dye). Further bioactivity was confirmed using the single-cell gel electrophoresis (Comet assay) to estimate levels of DNA damage. Fourier Transform Infrared analysis of bioactive extracts was performed to identify the functional groups present in them . Subsequently, bioactive extracts were further separated into acid, base, phenol and neutral fractions. These fractions and bioactive extracts were screened with the free radical assays to identify the scavenging activity. Chemical mapping of the bioactive fraction was performed with High Performance Liquid Chromatography (HPLC). Preparative-HPLC was performed to separate the compounds which were present in the bioactive fractions. MTT assay, Hydroxyl radical and nitric oxide radical scavenging activity assays were performed to screen the fractions and DNA protective activity of the bioactive fractions was confirmed with single-cell gel electrophoresis. These bioactive fractions were de-replicated with hyphenated techniques like LCMS and LCMS/MS to identify the molecular weight of the compounds and Quadrupole time-of-flight mass spectrometry was performed to identify the accurate mass of the compounds. Sequential extraction separates the non-polar and polar compounds present in the plant material. Qualitative analysis confirmed the presence of fatty acids in the non-polar extracts of both plants using GC and the presence of standard constituents in the polar extracts of both plants using HPLC. It also helps in chemical mapping of the extracts. Acetone, Methanol1 and Methanol2 extracts from either plant are non-cytotoxic. The high antioxidant activity is observed in methanol extracts from Andrographis paniculata and in acetone/methanol2 extracts from Silybum marianum. Extracts that protect against UVA and UVB damage also increased soluble collagen production in Human Dermal Fibroblast (HDF) in culture. Primary Screening helped to select six extracts out of twelve extracts for further analysis. Comet assay confirmed DNA protective activity in Methanol1 extract of Milk thistle and Acetone, Methanol2 extracts from Kalmegh. These three extracts were further fractionated into 38 fractions out of which three fractions that are F1, F13 and F31 fractions confirm the DNA protection activity. De-replication of the bioactive fractions was performed with LC-ESI-MS/MS which confirm twenty one compounds and accurate mass of fifteen compounds was determined using Q-tof mass spectrometry.

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Tonarová, Marta. "Analýza extraktu z listů Andrographis paniculata." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-379562.

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1 CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL BOTANY AND ECOLOGY Analysis of Andrographis leaves extract. Marta Tonarová, 2010 Abstract: The analysis of the extract of leaves Andrographis paniculata (Acanthaceae) was accomplished. The commercial ethanol extract with the contents of andrographolides not higher than 10 % represented the tested material. In case of using the standard andrographolide, the thin layer chromatography has proved its very low amount in the extract only, in spite of the fact that studying literature consideres its contents as majority. The identity of the standard was verified by mesuring its NMR spectrums, which refers to the informations in the studying literature. Contents of andrographolides was fixed by the high performance liquid chromatography extanded to the standard, with using of isocratic elution and spectrophotometric detection by the wave lenght 223 nm. Total contents of the andrographolides in the extract was 12,23 % and consequently it refers to the production protocol. The main component in the contents of the extract was isolated by using preparative TLC. On the basis of fixing the NMR spectrums and their confrontation with the studying literature it was determined as 14-deoxy-11,12-didehydroandrographolide.

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Chuang, Yalu, and 莊雅如. "Investigation of Effects of Andrographis paniculata." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/80377516070003898914.

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Yang, Shu-Fang, and 楊淑雱. "Role of Andrographis paniculata Extract in Neuroprotection." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/30755644843011053902.

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碩士
中華醫事科技大學
生物醫學研究所
100
Andrographis paniculata Nees., Family Acanthaceae, is a traditional folk medicinal plants, widely used in various applications, and has been used as antiinflammatory, antibacterial, antipyretic and immune promoting traditional therapeutic drugs. Excessive reactive oxygen radicals produced by oxidative stress make the brain hurt easily. It has been known that oxidative stress could easily lead to the generation of neurodegenerative diseases and the extract of Andrographis paniculata is a good antioxidant. Therefore, we used the human neuroblastoma IMR-32 cells treated with hydrogen peroxide and ethanol oxidation to investigate whether Andrographis paniculata extract has antioxidant neuroprotective effects. Under the cellular experimental conditions, the use of hydrogen peroxide and ethanol can induce cell death. To study the protective effects of Andrographis paniculata extract, we treated cells with hydrogen peroxide/ethanol and various concentrations of Andrographis paniculata extract (25, 50, 100, 200 μg/ml) for 24 hours and found the extract can protect cells from death. We studied whether the cell death via apoptosis using ApoGlowTM assay kit and found that hydrogen peroxide/ethanol induces apoptosis and Andrographis paniculata extract decreases the adverse effects. Integrated our experimental results, Chinese herbal medicine Andrographis paniculata extract protects nerve cells against oxidative stress injury. Maybe it can be used for prevention or treatment of neurodegenerative diseases in the future.

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Books on the topic "Andrographis paniculata"

Barilla, Jean. Andrographis Paniculata: Can herbs fight common ailments, cancer, and chronic viral infections? Keats Pub, 1999.

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Book chapters on the topic "Andrographis paniculata"

Sastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Andrographis paniculata (Green chirayta, Kalmegh)." In Encyclopedia of Plant Viruses and Viroids, 130–31. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_51.

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Tang, Weici, and Gerhard Eisenbrand. "Andrographis paniculata (Burm. f.) Nees." In Chinese Drugs of Plant Origin, 97–103. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-73739-8_14.

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Akbar, Shahid. "Andrographis paniculata (Burm. f.) Nees. (Acanthaceae)." In Handbook of 200 Medicinal Plants, 267–83. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-16807-0_26.

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Kunwar, Ripu M., Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Andrographis paniculata (Burm. F.) Wall. Acanthaceae." In Ethnobotany of the Himalayas, 1–4. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45597-2_22-1.

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Kunwar, Ripu M., Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Andrographis paniculata (Burm. f.) Wall. Acanthaceae." In Ethnobotany of the Himalayas, 235–38. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57408-6_22.

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Murthy, Hosakatte Niranjana, So Young Park, and Kee Yoeup Paek. "Domestication of Andrographis paniculata (King of Bitters)." In Sustainable Development and Biodiversity, 55–68. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74779-4_3.

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Parveen, Rabea, Bushra Parveen, Abida Parveen, and Sayeed Ahmad. "Andrographis paniculata: From Traditional to Nano Drug for Cancer Therapy." In Nanomaterials and Plant Potential, 317–45. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05569-1_13.

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Singh, P., M. M. Srivastava, D. K. Hazra, and L. D. Khemani. "Andrographolide: A Renoprotective Diterpene from Andrographis Paniculata (Burm. f.) Nees." In Chemistry of Phytopotentials: Health, Energy and Environmental Perspectives, 33–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23394-4_7.

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Panossian, Alexander, and Georg Wikman. "Efficacy of Andrographis paniculata in Upper Respiratory Tract Infectious Diseases and the Mechanism of Action." In Evidence and Rational Based Research on Chinese Drugs, 137–79. Vienna: Springer Vienna, 2012. http://dx.doi.org/10.1007/978-3-7091-0442-2_4.

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Sridharan, Badrinathan, and Meng-Jen Lee. "Andrographolide, a Diterpene from Andrographis paniculata, and its Influence on the Progression of Neurodegenerative Disorders." In Medicinal Herbs and Fungi, 79–112. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4141-8_3.

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Conference papers on the topic "Andrographis paniculata"

Sing, Dilip, Ranajoy Mallik, Sudarshana Ghosh Dastidar, Rajib Bandyopadhyay, Subhadip Banerjee, Shibu Narayan Jana, and Pulok K. Mukherjee. "Prediction of Andrographolide Content in Andrographis paniculata Using NIR Spectroscopy." In 2020 IEEE Applied Signal Processing Conference (ASPCON). IEEE, 2020. http://dx.doi.org/10.1109/aspcon49795.2020.9276668.

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"Analisa Potensi Ekstrak Etanol Andrographis paniculata, Nees sebagai Alternatif Antelmintik Fitofarmaka." In Teknologi Peternakan dan Veteriner Mendukung Kemandirian Pangan di Era Industri 4.0. Pusat Penelitian dan Pengembangan Peternakan, 2019. http://dx.doi.org/10.14334/pros.semnas.tpv-2019-p.435-443.

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Sumarmin, Ramadhan, Nadyatul Khaira Huda, and Yusni Atifah. "Effect of Bitter Extract (Andrographis paniculata Nees.) to Epididymal Mice Sperm Quality." In International Conference on Biology, Sciences and Education (ICoBioSE 2019). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/absr.k.200807.023.

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Arbianti, Rita, Veronica Dewi, Farisa Imansari, Heri Hermansyah, and Muhamad Sahlan. "Nano-preparation of Andrographis paniculata extract by casein micelle for antidiabetic agent." In BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the First International Symposium of Biomedical Engineering (ISBE 2016). Author(s), 2017. http://dx.doi.org/10.1063/1.4976779.

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Sukardiman, Rakhmawati, Alvi Prabowo, and Lusiana Arifianti. "Standardization Raw Material and Ethanolic Extract of Andrographidis Herba (Andrographis paniculata Nees) from District of Bogor and Tawangmangu." In Bromo Conference, Symposium on Natural Products and Biodiversity. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008361402840287.

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Sudarmi, Ms, Wiwik Darmini, and Ms Wartini. "Activity of Sambiloto Extract (Andrographis paniculata Ness) in Reducing Total Blood Cholesterol Levels Hypercholesterolemia Rats." In International Conference on Applied Science and Engineering (ICASE 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/icase-18.2018.33.

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"Inhibitory Activities of Methanol Extracts of Andrographis Paniculata and Ocimum Sanctum against Dengue-1 Virus." In International Conference on Biological, Environment and Food Engineering. International Institute of Chemical, Biological & Environmental Engineering, 2014. http://dx.doi.org/10.15242/iicbe.c814013.

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Fardiyah, Qonitah, Suprapto, and Fredy Kurniawan. "Fluorescence analysis of Andrographis paniculata L. ness medicinal plant extract as a potential protector of ultraviolet radiation." In THE 3RD INTERNATIONAL SEMINAR ON CHEMISTRY: Green Chemistry and its Role for Sustainability. Author(s), 2018. http://dx.doi.org/10.1063/1.5082422.

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Maylana, Rani, Wiwied Ekasari, Lusiana Arifianti, Hadi Poerwono, and Sukardiman. "Antidiabetic Activity of Diterpene Lactone Fraction of "Sambiloto" (Andrographis paniculata Nees.) on Mice (Mus musculus) Induced by Alloxan." In Bromo Conference, Symposium on Natural Products and Biodiversity. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008361202770280.

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Sahlan, Muhamad, Katerina Evelyn, Diah Kartika Pratami, and Kamarza Mulia. "In vitro release study of sambiloto (Andrographis paniculata) extract encapsulated by casein micelle as anti-diabetic herbal drug." In PROCEEDINGS OF THE 5TH INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY 2019. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5134606.

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