Dissertations / Theses on the topic 'Androgens'
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Van, Oeveren Margaret Ann. "Interpersonal functional flexibility : an antecedent of authoritative parenting?" Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28305.
Full textArts, Faculty of
Social Work, School of
Graduate
Sharp, Danae Maree. "Androgens induce gender- & dose- specific effects on atherogenesis." Connect to full text, 2008. http://hdl.handle.net/2123/4158.
Full textSubmitted in fulfilment of the requirements for the degree of Master of Science in Medicine to the Discipline of Medicine, Faculty of Medicine. Degree awarded 2009; thesis submitted 2008. Title from title screen (viewed Apr. 14, 2008) Includes bibliography. Also available in print form.
Suri, Narinder K. "Androgens and the endometrium." Thesis, University of Nottingham, 1988. http://eprints.nottingham.ac.uk/13915/.
Full textTyndall, Victoria. "Androgens and the ovary." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5591.
Full textCloke, Brianna. "The role of Androgens and the Androgen receptor in human endometrial stromal cell decidualization." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510758.
Full textZahaf, Amina. "Rôle inattendu de la signalisation des androgènes dans le système nerveux central démyélinisé de la souris femelle : Identification de spécificités liées au sexe de l'animal." Thesis, université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL046.
Full textMultiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). The pathology is characterized by successive inflammatory insults, which are related to the dysregulation of the immune system and target the cells synthesizing myelin in the CNS, the oligodendrocytes. These insults are followed by steps of remission corresponding to the spontaneous regeneration of myelin, also called remyelination. However, when the disease progress, remyelination fails namely due to a lesion environment becoming inappropriate. The pathology characterized as chronic and neurodegenerative concerns 3 women for 1 men and is currently considered as the first cause of non traumatic disabilities in the young adults. During the last decades, a substantial number of molecules targeting the immune system has been identified in order to reduce the frequency and severity of the insults. These molecules are efficient on the relapsing-remitting form of the disease, but they become inefficient with disease progression. The current therapeutic challenge is the identification of molecules also able to boost the regeneration of myelin. The role of the male sexual hormones or androgens in models of CNS demyelination has been thoroughly investigated in males, which led to show their immunomodulatory, pro-myelinating and neuroprotective properties. Since females also produce androgens - though at a much lower level than males - the objective of my PhD project was to delineate the contribution of androgens to the protective and regenerative processes involved in the context of CNS demyelination in female mice. In immune (EAE) and non-immune (LPC) models of CNS demyelination, the effects of androgens have been analyzed via immunostaining experiments, visualization of myelin and axon ultrastructure, fluorescence-activated sorting of peripheral immune cells present in the lymphoid organs or infiltrated in the CNS. The data indicate major remyelinating, anti-inflammatory and neuroprotective activities of androgens in females as previously observed in males with however some specificities. Moreover, transcriptomic analysis of the spinal cord from EAE animals led us to identify profiles of deregulated genes tightly correlated with the histological and functional data. Altogether these results suggest that the administration of appropriate doses of androgens would deserve to be further considered in female patients presenting with multiple sclerosis
Shiwlochan, Amrita G. "Prenatal androgens and visceral fat." Honors in the Major Thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1327.
Full textBachelors
Sciences
Anthropology
Pettiford, Jasmine. "Effect of garlic-deriveds-allylmercaptocysteine on androgen receptor expression in androgen-independent prostate cancer." Thesis, Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41005545.
Full textSantana, Luís Carlos Leal. "Impacto de andrógenos sobre a proliferação e atividade de fibroblastos e células epiteliais em cultura celular /." Araraquara, 2016. http://hdl.handle.net/11449/138766.
Full textResumo: Hormônios esteroides sexuais participam de diversos eventos celulares e moleculares, e exercem influência sobre o epitélio e tecido conjuntivo do periodonto. A testosterona (T), principal hormônio androgênico, pode ser convertida em estradiol (E2) pela ação da enzima aromatase, ou em di-hidrotestosterona (DHT) pela ação da enzima 5α-redutase. Para elucidar o impacto de andrógenos sobre as células que compõem os tecidos conjuntivo e epitelial, fibroblastos e queratinócitos foram avaliados em relação aos efeitos de diferentes concentrações de T e DHT, além da exposição ao anastrozol (ANA), flutamida (FLU), fulvestranto (FUL), e às associações farmacológicas T+ANA, T+FLU e T+FUL. Os resultados do presente estudo indicaram que, de modo geral, hormônios esteroides androgênicos exercem efeitos opostos sobre eventos celulares de fibroblastos gengivais humano e células epiteliais HaCaT em cultura celular. Enquanto a T e a DHT agem promovendo o aumento da proliferação e atividade de fibroblastos, a exposição de células HaCaT a estes mesmos andrógenos resulta em inibição ou exiguidade do crescimento celular, atividade metabólica ou a capacidade de repovoamento da área de arranhão in vitro. Além disso, o tratamento farmacológico com ANA, FLU, FUL, e suas respectivas associações à T, parece influenciar eventos celulares de fibroblastos gengivais humano e células epiteliais HaCaT in vitro.
Abstract: Sex steroid hormones take part in different cellular and molecular process and exert their functions on the epithelium and connective tissue of the periodontium. Testosterone (T), the main androgenic hormone can be converted to estradiol (E2) through the aromatase enzyme action, or into dihydrotestosterone (DHT) by 5α-reductase activity. To elucidate the impact of androgens on the cells that constitute the connective and epithelial tissues, fibroblasts and keratinocytes were evaluated under the effects of different concentrations of T and DHT, besides to be both exposed to anastrozole (ANA), flutamide (FLU), fulvestrant (FUL), and the pharmacological associations T+ANA, T+FLU and T+FUL. The results of this study indicated that, in general, androgenic steroid hormones exert opposite effects on cellular events of human gingival fibroblasts and epithelial cells. While androgens act stimulating gingival fibroblasts, in HaCaT cells androgens promotes a shortage or inhibition of cell growth and activity. Furthermore, pharmacological treatment with ANA, FLU, FUL, and their associations to T, appears to influence cellular events of human gingival fibroblasts and HaCaT cells in vitro.
Mestre
Xu, Huiping. "Electrophilic androgen receptor ligands as chemotherapeutic agents for prostate cancer." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1089126757.
Full textDocument formatted into pages; contains xxviii, 261 p. Includes bibliographical references (p. 141-149). Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 July 6.
Dockery, Frances. "Androgens and cardiovascular disease in men." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435055.
Full textDean, Afshan. "Androgens and the masculinisation programming window." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6516.
Full textKearbey, Jeffrey Dale. "Preclinical pharmacokinetics and skeletal pharmacology of a selective androgen receptor modulator." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085168433.
Full textDocument formatted into pages; contains xvii, 162 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 May 24.
Choi, Jaesung (Peter). "The role of androgens acting via androgen receptor in uterine development and PTEN deletion induced uterine cancer." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14437.
Full textYang, Chih-Cheng. "Strategies to overcome progression of androgen refractory prostate cancer targeting Bcl-xL and androgen receptor." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1165358220.
Full textSharp, Danae Maree. "ANDROGENS INDUCE GENDER- & DOSE- SPECIFIC EFFECTS ON ATHEROGENESIS." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/4158.
Full textSharp, Danae Maree. "ANDROGENS INDUCE GENDER- & DOSE- SPECIFIC EFFECTS ON ATHEROGENESIS." University of Sydney, 2009. http://hdl.handle.net/2123/4158.
Full textCardiovascular disease (CVD) is the major cause of morbidity and mortality in developed countries. Men have a higher incidence and an earlier onset of CVD than age-matched women. It has been shown that young women have lower CVD incidence than young men and the increase in CVD rates in older (post-menopausal) women when estrogen levels decline suggests that estrogens are cardioprotective. This theory has been extensively investigated demonstrating a favourable reduction in LDL, reducing expression of cell adhesion molecules and promoting vasodilatation by inducing nitric oxide (NO) production in endothelial cells. However, not many studies have explored the alternate theory that male sex hormones, androgens (T & DHT), may promote CVD. Investigators examining male androgens in vivo have shown inconsistent results, with both adverse and protective effects on atherosclerosis formation. This study aimed to elucidate the role of androgens and their effects on the formation and progression of atherosclerotic plaque in males and females. Chapter 3 describes the establishment of the en face Oil Red O for quantitating atherosclerotic plaque. The Oil Red O technique was employed to compare the reliability and the consistency of the plaque area to the already established H&E staining method. This chapter focuses on the en face Oil Red O staining technique to see if the new method could give a faster, more efficient and reliable alternative to the very labour intensive H&E staining. From this study the en face Oil Red O staining technique was a more time and labour efficient method that is a reliable method to the already establish H&E staining when investigating atherosclerotic plaque levels. Chapter 4 examines the effect of exogenously administered male sex hormones, testosterone (T) and dihydrotestosterone (DHT), on atherosclerosis in male and female ApoE-/- mice. The aim of this experiment was to examine if the androgens had a dose- and or gender- specific effect on the plaque formation in the animals. The experimental design involved the use of three different doses of high (1cm implant), medium (0.5 cm implant) and low (0.25 cm implant) T or DHT and the mice were treated for a period of 16-weeks. The results showed that T had gender- and dose- specific effects. Briefly, there was no effect of T treatment on plaque formation in females. However, in males, the high dose of T decreased plaque but at the low dose T had the opposite effect by increasing plaque levels. The DHT results differed to the T results indicating different pathways of action. DHT treatment in the females demonstrated atheroprotective effects at the high and medium dose. The males had no effect at the high dose of DHT but the low dose was atherogenic. Chapter 5 aimed to explore the effect of DHT treatment in cells involved in early atherogenic processes using male and female HUVEC and MDM and to ascertain if AR cofactors are hormonal regulated. The results showed that there was no hormonal regulation in the MDM by DHT. Alternatively, in HUVEC there was a significant up-regulation of ARA24, ARA54, ARA160 and SRC-1 mRNA levels with DHT treatment and a down-regulation of p300 and NCoR1 mRNA levels. In particular, this chapter also investigated protein expression of the cofactor SRC-1 in HUVEC, which was increased in males with DHT treatment. SRC-1 protein levels were also examined with in vivo studies. Different doses of T and DHT were administered to male and female ApoE-/- mice. The 0.5 cm and 1 cm dose of T in the male showed an increase in the SRC-1 protein level and DHT, at the 0.25 cm and 0.5 cm implant increased SRC-1 protein levels. SRC-1 levels in female animals did not change with any dose of DHT, whereas the 0.25 cm T showed an increase in SRC-1 and 0.5 cm T implant decreased SRC-1 protein levels. This study demonstrates that AR cofactors can be hormonally regulated by androgens at the mRNA and protein level. Overall, male sex hormones have an effect on atherosclerosis formation. Androgens have important gender- and dose- specific effects on plaque formation, and can hormonally regulate AR cofactors at the mRNA and protein level. The results of this thesis have produced more questions than it has answered. This study requires further investigation into the benefits and consequences of using androgens, examining the underlying molecular pathways that may be involved with the AR cofactors and the use of exogenous androgen treatment for both men and women.
McFadden, Michael Patrick. "Effects of prenatal androgen exposure on postnatal growth, estrous cyclicity and behavior in female beef cattle." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/43050.
Full textMaster of Science
Gao, Wenqing. "Pharmacology of selective androgen receptor modulators (SARMS)." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085757928.
Full textDocument formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 May 28.
Simitsidellis, Ioannis. "Identifying the role of androgens in endometrial function." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25773.
Full textJimenez, Esbal. "Effects of Androgens on Reproduction in Female Pigs." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1206382656.
Full textBerg, Melanie Dawn. "Yolk androgens and development in American kestrel nestlings." [Boise, Idaho] : Boise State University, 2009. http://scholarworks.boisestate.edu/td/11/.
Full textLesmana, Brian. "The Role of Androgens in Burn Wound Healing." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21115.
Full textPincott, Cynthia. "Observations on the association of androgen-receptor complexes with the nuclear matrix of human genital skin fibroblasts." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63847.
Full textSperry, Todd Samuel. "Studies on the biochemical characteristics of two distinct nuclear androgen receptors in Atlantic croaker, Micropogonias undulatus /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Full textKhoo, Sue-Anne. "Effects of intermittent androgen suppression therapy on cognitive functioning and quality of life in men with metastatic prostate cancer /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16253.pdf.
Full textScott, Hayley M. "The role of androgens in testicular development and dysgenesis." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2687.
Full textDobson, Katharine Rebecca. "Studies into the effects of androgens on bone formation." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301007.
Full textHuaikai, Sai. "The Role of Androgens in Burn Injury Wound Healing." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23771.
Full textCaldwell, Aimee Sarah Lee. "Unravelling The Role Of Androgens In Polycystic Ovary Syndrome." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18129.
Full textKamal, A. M. "Endometrial cancer : involvement of androgens and metastasis inducing proteins." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004396/.
Full textChong, Jessica. "The role of androgens in the female genital tract." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21137.
Full textThe view of androgens as a chiefly male- associated hormone is long outdated, and there is an increasing wealth of evidence for the role of androgens in women. Androgens, in addition to estrogen and other hormones, play several various and critical roles in females, particularly in the development and function of the female genital tract. Countless, targeted studies have been conducted in efforts to elucidate how androgens affect the development and function of the female genitalia, most notably in regards to the vagina, uterus, and ovaries. However, though the significance of female androgens is relatively well established, knowledge on this subject is still developing and somewhat fragmented. The objective of this review is to present a comprehensive view of the role of androgens in the development and function of the female genital tract, summarize new studies, and integrate the most current information in order to gain a broadened and enhanced understanding of the importance and implications of androgens in females.
2031-01-01
Mason, Rachel Ann. "Effects of estrogens and androgens on bone cell metabolism /." Title page, table of contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm411.pdf.
Full textLindström, Sara. "Genetic variation and prostate cancer : population-based association studies in Sweden /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1329.
Full textČeponis, Jonas. "Jaunų ir vidutinio amžiaus vyrų reprodukcinės sveikatos ryšys su antropometrija, metaboline bei psichologine būkle." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140714_134831-56285.
Full textAssociations between androgens and various metabolic factors, as well as cardiovascular morbidity shown in recent epidemiological studies sparked interest in new aspects of male reproductive health. Reference values for normal androgen levels in Lithuanian population have not yet been established and no relationship studies on reproductive health and anthropometric, as well as metabolic parameters have been performed. Unequivocal information on associations among the aforementioned factors is lacking globally, especially those performed in homogenous populations. More information on androgen associations with cognitive function, emotional state and evaluation of quality of life is required. Most of the studies on effectiveness of testosterone replacement therapy were of short duration and mostly focused on structural, rather than functional parameters. The purpose of the study was to describe associations between reproductive health and anthropometric, metabolic, as well as psychological parameters in young and middle-aged men. This is the largest androgen association analysis in Lithuanian population. This work seeks for systematic responses to questions of interest: to establish reference values for normal and optimal androgen levels, to evaluate their relationship with anthropometric and metabolic factors in populations that are homogenous by age, and to assess the functional changes that long-term optimal testosterone replacement therapy may induce in patients with... [to full text]
Coss, Christopher C. "Selective Androgen Receptor Modulator (SARM) Action: Androgen Therapy Revisited." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1227282252.
Full textYu, Frank Hong. "The effects of hydroxyflutamide on action and production of androgens in rats induced to superovulate." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29409.
Full textMedicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate
Elhaji, Youssef A. "Androgen receptor mutation in breast cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0002/MQ44162.pdf.
Full textSöderström, Torbjörn. "Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-12-9/.
Full textStubbs, Andrew Peter. "Sex steroids in human hepatocellular carcinoma : metabolism, receptor expression and binding protein modulation." Thesis, King's College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299135.
Full textMakieva, Sofia. "Investigating the role of androgens in myometrial biology during pregnancy." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15950.
Full textQureshi, Asjid Iqbal. "The role of androgens in prenatal folliculogenesis in polycystic ovaries." Thesis, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428952.
Full textSwales, A. "The effect of oestrogens and androgens on mammalian oocyte maturation." Thesis, University of Edinburgh, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662647.
Full textSirab, Nanour. "Interaction entre la voie Hedgehog et les hormones stéroïdiennes dans les cellules normales et cancéreuses de la prostate." Thesis, Paris Est, 2010. http://www.theses.fr/2010PEST0050.
Full textProstate cancer (PCa) is the most frequent male malignancy and the second most common cause of cancer-related death in men. This cancer is androgen sensitive in its development and progression to metastatic disease. Despite this, increasing evidence suggest that androgens alone are not able to induce PCa and estrogen signaling has a key role in prostate cancer progression. Hedgehog (Hh) pathway activation is important in the growth and development of various carcinomas including PCa. A better understanding of Hh pathway regulating mechanisms in PCa is important in order to identify new therapeutic strategies for this pathology. In this study we investigate the interaction between Hh pathway and steroid hormones in prostate cells. We showed: i) Hh pathway activation by the estrogen (estrone sulfate E1S), attenuated by the anti-estrogen (ICI) and by the Hh pathway inhibitor (KAAD-cyclopamine) ii) Hh pathway negative regulation by the androgen (dihydrotestostérone (DHT)) and the estrogen (17β-estradiol (E2)). Moreover, we showed that Hh pathway inhibition is androgen receptor (AR) dependent. However, E1S effect on this pathway might be estrogen receptor (ER) dependent. Finally, our results suggest that targeting AR signaling by cyclopamine derivatives could be promising therapeutic alternative in prostate cancer, which needs a further investigation
Vingren, Jakob L. "Effect of Chronic Alcohol Abuse and Resistance Training on the Skeletal Muscle Androgen Receptor Concentration of Rats." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4540/.
Full textGannon, Anne-Louise. "Determining the role of androgen receptor and glucocorticoid receptor in the rodent adrenal cortex through conditional gene targeting." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31072.
Full textWainwright, Steven R. "Androgens and neuroplasticity : contributions to the pathogenesis and treatment of depression." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55848.
Full textMedicine, Faculty of
Graduate
Galioto, Rebecca. "The effects of androgens on lymphocyte infiltration into the porcine endometrium." Connect to resource, 2007. http://hdl.handle.net/1811/28350.
Full textTitle from first page of PDF file. Document formatted into pages: contains 10 p.; also includes graphics. Includes bibliographical references (p. 10). Available online via Ohio State University's Knowledge Bank.
Gonçalo, Aires de Oliveira. "Social modulation of androgens in humans : Psychological mechanisms and adaptative function." Doctoral thesis, ISPA - Instituto Universitário das Ciências Psicológicas, Sociais e da Vida, 2015. http://hdl.handle.net/10400.12/4319.
Full textEsta tese procura clarificar os processos subjacentes às discrepâncias entre a direcção da resposta de androgénios à competição encontrada em estudos empíricos e as predicções das teorias para a modulação social de androgénios. Sugerimos que estes resultados imprevistos podem resultar de interacções com variáveis cognitivas e elegemos especificamente a avaliação cognitiva como um forte candidato a moderador da resposta de testosterona (T) aos desafios sociais. Várias experiências foram realizadas para testar esta hipótese. No Capítulo II e III, testou-se o efeito da familiaridade do oponente e da avaliação do resultado da competição como ameaça/desafio, na resposta de T a uma competição contra um membro do mesmo sexo. Nas mulheres foi encontrado um maior aumento dos níveis de T quando eram derrotadas por um oponente não familiar e quando o resultado era avaliado como ameaçador. Este efeito de moderação não foi detectado para os homens. Continuou-se a investigação sobre os efeitos da familiaridade do oponente e avaliação de ameaça no Capítulo IV, mas com um ciclídeo. Num paradigma de repetidas invasões territoriais por machos estranhos e familiares, encontrou-se uma maior resposta de androgénios no macho residente para as intrusões realizadas por um estranho, comparada com as de um macho familiar. O efeito do componente de expectativas da avaliação cognitiva, na resposta de T à competição em mulheres, foi testado através da manipulação das expectativas dos participantes em relação ao resultado da competição antes da tarefa competitiva (Capítulo V). Os vencedores inesperados baixaram os níveis de T depois da competição, mostrando uma inversão da resposta predicta pelos modelos teóricos. No Capítulo VI, testou-se o efeito directo das alterações afectivas nos níveis de T usando excertos de filmes emocionais. Um decréscimo significativo de T foi observado nos participantes da condição de tristeza, numa direcção congruente com as predicções da literatura. Finalmente, no Capítulo VII, abordou-se a função adaptiva das mudanças de androgénios induzidas pela competição proposta pelos modelos teóricos. Especificamente, testou-se o efeito do resultado da competição e dos níveis pós-competitivos de T na capacidade do individuo detectar faces emocionais ameaçadoras. Os nossos resultados sugerem que os vencedores foram mais rápidos e melhores a discriminar faces de raiva do que os perdedores. A discriminação de raiva foi também melhorada quando os níveis de T pós-competição eram elevados. No geral, estes resultados apoiam a hipótese de uma moderação cognitiva da resposta de T em mulheres. As implicações destes resultados para as teorias de modulação social de andrógenios são discutidas numa perspectiva comparada e integrativa.
ABSTRACT : This thesis aims to clarify the processes underlying the discrepancies between the direction of the androgen response to competition found in empirical studies and predictions of the theories for the social modulation of androgens. We suggest that these unpredicted results could result from interactions with cognitive variables and specifically select appraisal as a strong candidate to moderate the testosterone (T) response to social challenges. Several experiments were conducted to test this hypothesis. On Chapter II and III, we have tested the effect of opponent familiarity and the evaluation of the competition outcome as a threat/challenge on the T response to a competition with a member of the same sex. We have found that women show greater increases in T levels when they were defeated by an unfamiliar opponent and evaluated the outcome as threat. This moderation effect was not detected for men. We have continued the research on the effects of opponent familiarity and threat assessment on Chapter IV, but this time using a cichlid fish. In a paradigm of repeated territorial intrusions by stranger and familiar males, the resident male’s androgen response was higher for the intrusions performed by a stranger compared to those performed by a familiar male. The effect of the expectations component of appraisal on the T response to competition in women was tested by manipulating the expectations of the participants on the outcome of the competition before the competitive task (Chapter V). We have found that the unexpected winners decreased their T levels, showing a reversal of response predicted by the theoretical models. On Chapter VI, we have tested the direct effect of affective changes on T levels using emotional film clips. T significantly decreased for those participants assigned to the sadness condition, a direction that is congruent with predictions of the literature. Finally, on Chapter VII, we have addressed the adaptive function of the androgen changes elicited by the competition, as proposed by the theoretical models. Specifically, we have tested the effect of the competition outcome and post-competition T levels on the individual’s capacity to detect threatening emotional faces. Our findings suggest that winners were faster and better in discriminating angry faces than losers. Anger discrimination was also enhanced when post-competition T levels were high. Together these findings support the hypothesis of a cognitive moderation of the T response to competition in women. Results are discussed in terms of their implication to the theories for the social modulation of androgens in a comparative and integrative perspective.
Huber, Dustin Michael. "ANDROGENS SUPPRESS OSTEOCLAST FORMATION INDUCED BY RANK LIGAND AND M-CSF." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin999020063.
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