Journal articles on the topic 'And Josephine H'

Review of: Digital Innovations and the Production of Local Content in Community Radio: Changing Practices in the UK, Josephine F. Coleman (2021) Oxon: Routledge Focus, 134 pp., ISBN 978-0-36750-702-2, h/bk, £35.99

ABSTRACT This article investigates the public activism of TheWoman’s Era newspaper (1894–97), which was one of the first African American feminist periodicals to derive national circulation in the United States in the latter half of the nineteenth century. Considering TheWoman’s Era’s coverage of activist efforts to build African American public reading rooms and libraries, this article suggests that African American feminist writers and editors, such as Florida R. Ridley and Josephine St. Pierre Ruffin, sought to revise the concept of the public sphere by broadening who had access to public space and altering how blackness was represented within these spaces. This article draws from archival work derived from Emory University’s Emory Women Writers Resource Project in collaboration with the Lewis H. Beck Center at Woodruff Library and the Virtual Library Project, which offers transcribed reproductions of TheWoman’s Era and includes downloadable images of individual pages and advertisements. Given the scope of such research, which attempts to read African American women’s public writing through a rhetorical and close-textual lens, Emory University’s digital archives provide a valuable frame of reference for charting the currency of specific terms, such as “public space,” “public interest,” “public opinion,” and “public good.” The goal of this project is to offer a discursive interpretation of how appeals to “the public” as both a material and a conceptual space denoting citizen rights and resources was used and deployed by African American feminist activists for the purposes of uplifting minority communities and developing African American women’s voices.

Species of the Habenaria josephi group in the Pan-Himalaya region are revised, based on their morphological characters and results of previous molecular phylogenetics. Eight distinctive species are recognised; key to the species, taxonomic descriptions, illustrations and distribution maps are provided. Habenaria josephi is re-instated, based on morphological and molecular evidence; H. wolongensis is synonymised with H. aitchisonii, a neotype for H. tibetica and the lectotypes for H. balfouriana, H. fargesii, H. glaucifolia and H. clarkei are designated.

A new species of Orchidaceae, Habenaria tiechangensis, from Yunnan province is described and illustrated based on morphological characters and molecular phylogenetic analysis. The results indicated that it belongs to H. josephi group and is similar to H. diplonema but differs from the latter by having short and lanceolate lateral lobes of lip and a pair of distinctive horn-like stigmas.

Abstract Introduction: There is a critical need to incorporate molecular assessments of minimal residual disease (MRD) during neoadjuvant immunotherapy, in order to identify individuals at high risk for disease recurrence based on analyses of circulating cell-free tumor DNA (ctDNA) landscapes. Here we employed longitudinal liquid biopsies to dynamically assess clinical outcomes with neoadjuvant immuno-chemoradiotherapy in patients with esophageal/gastroesophageal junction (E/GEJ) cancer. Methods: We utilized targeted error-correction sequencing to perform high-depth ctDNA next-generation sequencing for 141 serial plasma and 32 matched white blood cell (WBC) DNA samples from 32 patients with operable stage II/III E/GEJ cancer that received neoadjuvant immune checkpoint blockade (ICB) with chemoradiotherapy prior to surgery (NCT03044613). ctDNA analyses were performed at baseline, post-ICB induction, after completion of chemoradiotherapy (pre-op), and post-operatively (post-op). Using a tumor-agnostic WBC DNA-informed panel NGS approach we determined the cellular origin of plasma variants, filtering out germline and clonal hematopoiesis (CH) variants and evaluated ctDNA clonal dynamics over time. Molecular MRD was evaluated post-ICB, pre-op and post-op and correlated with recurrence-free (RFS) and overall survival (OS). Results: Twenty out of 32 patients had detectable ctDNA at any timepoint. Of the 12 patients with undetectable ctDNA, 9 had only CH- and/or germline-derived variants, while 3 patients had no detectable variants of any origin. ctDNA clearance post-ICB was correlated with tumor regression >80% at the time of resection (Fischer’s exact p=0.04). The subset of patients that did not attain complete pathologic response was heterogeneous with respect to ctDNA dynamics; such that ctDNA clearance pre-op identified patients with longer OS despite residual tumor of >0% at the time of resection (log rank p=0.06). Patients with undetectable ctDNA or ctDNA clearance pre-op had a longer RFS (log rank p=0.007) and OS (log rank p=0.03). Molecular MRD was associated with RFS and OS such that patients with ctDNA clearance post-op had longer RFS (log-rank p=0.007) and OS (log-rank p=0.017). Conclusion: ctDNA clearance post-ICB, pre-op and post-op reflects differential clinical outcomes for patients with E/GEJ cancer receiving neoadjuvant immuno-chemoradiotherapy. Understanding ctDNA dynamics and their relationship with pathological response and long-term outcomes can help identify patients at higher risk for recurrence and open a therapeutic window for future intervention. Citation Format: Blair V. Landon, Ronan J. Kelly, Ali H. Zaidi, Archana Balan, Jenna V. Canzoniero, Gavin Pereira, Zineb Belcaid, Russell K. Hales, K Ranh Voong, Richard J. Battafarano, Blair A. Jobe, Stephen C. Yang, Stephen Broderick, Jinny Ha, Kellie N. Smith, Elizabeth Thompson, Fyza Y. Shaikh, James R. White, Cynthia L. Sears, Eun J. Shin, Ali I. Amjad, Benny Weksler, Josephine L. Feliciano, Chen Hu, Vincent K. Lam, Valsamo Anagnostou. Circulating cell-free tumor DNA dynamics capture minimal residual disease with neoadjuvant immune checkpoint blockade plus chemoradiotherapy for patients with operable esophageal/gastroesophageal junction cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3374.

Abstract Background: Over the past decade, there have been notable changes in the definition of risk estimation in patients with early-stage breast cancer (EBC). Specifically, within the timeframe of 2000 to 2017, following Estrogen Receptor (ER) positive and HER2-negative EBC cases were classified as low risk according to the University Hospitals of Leuven (UHL) criteria of that time: if ER H-score was >200: all patients with tumors N0 and Grade (G) 1, ≤pT2; or G2-3 pT1a-b; in patients ≥40 years with tumors N0 and G2 pT1c-2 or G3 pT1c; in patients ≥ 55 years with tumors N0 G3 pT2 or N1 any Grade, pT≤2. For lower H-scores, other criteria applied. However, despite undergoing endocrine therapy, a subset of these patients with clinically low-risk tumors unexpectedly experienced metastasis within five years of initial diagnosis. This unforeseen outcome may indicate potential undertreatment, as these patients did not receive adjuvant chemotherapy. We have conducted a case-cohort study of those patients with early relapse and performed the current clinical risk assessment methods and genomic risk analyses. Methods: In this study, we included patients with ER-pos, HER2-neg early-stage breast cancer diagnosed between 1-1-2000 and 31-12-2017, who were classified as low-risk tumors by UHL guidelines at that time, who were older than 35 but younger than 71 years, had an unilateral, unifocal breast tumor with tumor size up to 5 cm. These patients did not receive adjuvant chemotherapy. We selected the patients that experienced early distant recurrence, defined as distant recurrence (DR) within 5 years after the initial diagnosis. To ensure comparability for the analyses they were matched to controls for grade, menopausal status, tumor size, lymphovascular invasion, progesterone receptor status, and the year of diagnosis. For each patient, we have calculated the clinical risk score according to the criteria outlined by Mymammaprint.com, based on the modified Adjuvant Online tool used in the MINDACT trial. For the analysis, formalin-fixed paraffin-embedded (FFPE) breast tumor tissue samples were subjected to in-house validated targeted RNA-based Mammaprint(MP) analysis by NGS (MP Agendia). Results: Of the 3190 patients with EBC at UHL during the study period, 2476 patients were considered for this analysis and fitted the clinical low-risk criteria defined low-risk at UHL. Among those, only 42 or 1.7% of the eligible cohort had developed metastasis within 5 years. Tissue for MP analysis was available for 35 of these cases and for their matched control. Due to technical failure, the 1:1 matching was lost and MP results were known for 28 cases and 27 controls. The patient and tumor characteristics of both groups were comparable. In this UHL clinical low-risk group, 21/28 (75%) cases would be identified as clinical high-risk by MyMammaprint.com and 18/27 (67%) controls. We identified 13 patients (46.43%) with high genomic risk within the group with DR and 9 (33.33%) within the control group. There was no statistically significant difference (p=0.412) in the proportion of genomically high-risk patients within the group with DR compared to the control group. Conclusions: In a database of patients with EBC of whom 98% did not develop metastasis within 5 years, we observed in a small series of chemotherapy naïve patients with early DR and UHL-defined clinical low-risk tumors, that nearly half had a genomically high risk of distant metastasis. Albeit numerically higher than the matched-control group, this observation was not significant and would warrant a larger sample size and power to confirm these results. Table. Genomic versus Clinical Risk by MyMammaprint.com Citation Format: Josephine Van Cauwenberge, Hava Izci, Hans Wildiers, Sileny Han, Christine Desmedt, Giuseppe Floris, Sara Vander Borght, Ann Smeets, Ines Nevelsteen, Isabelle Vanden Bempt, Patrick Neven. Genomic risk analyses in patients with clinical low risk ER-positive HER2-negative early breast cancer developing an early metastatic event [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-01-14.

Abstract Background: Preclinical and clinical data indicate that neoadjuvant chemoradiotherapy (CRT) may prime an anti-tumor immunological response in esophageal cancer driven by intratumoral CD8+ T cells and PD-L1 expression. LAG-3 is also highly expressed in esophagogastric cancers. The microbiome, a novel and potentially modifiable, biomarker of IO response, has not yet been examined in the neoadjuvant setting in esophageal cancer and is the goal of our study. Methods: Fecal samples were collected from patients with stage II/III esophageal or gastroesophageal junction carcinoma eligible for curative resection treated with the standard of care regimen of carboplatin paclitaxel (50mg/m2), radiation 50.4 Gy in 28 fractions and an Ivor-Lewis esophagectomy 6-10 weeks after last CRT and immunotherapy (IO) dose. Patients on arm A (n=11) received 2 cycles of induction with nivolumab plus 3 additional cycles on week 1, 3 and 5 of CRT. Patients on arm B (n=8) received nivolumab plus relatlimab on the same schedule (Clinical trial: NCT03044613). We examined longitudinal fecal samples from n=19 patients across both arms (n=90 samples) using 16S rRNA amplicon sequencing. Patients were classified based on pathological response: complete response (CR) and grades 1, 2, and 3 (G1, G2, G3) with increasing residual tumor visible in the resected specimen. Sequencing data was trimmed and filtered for contaminants, followed by high-resolution taxonomic assignment and normalization of reads across all samples. Analysis was performed using multiple metrics for alpha diversity and beta-diversity, with principal coordinates analysis/PERMANOVA, and pathway analysis using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Results: Patients with improved response in the neoadjuvant setting (CR/G1 vs G2/G3) grouped in distinct clusters using Bray-Curtis (p < 0.001). Patients with CR had higher alpha diversity, using both measures of richness and evenness, compared to patients with a G3 responses (p < 0.03). Specifically, family Bacteroidaceae and genus Bacteroides were enriched in patients with CR vs G3 (p < 0.02). At the species level, B. finegoldii, B. ovatus, and B. uniformis were enriched in patients with CR vs G3 (p < 0.02). In contrast, genus Klebsiella and Clostridium termitidis were enriched in patients with a poor response, G3 (p <0.001, both). Pathway analysis found two metabolic pathways enriched in patients with CR: secondary bile acid biosynthesis (p=0.005) and lysine biosynthesis (p=0.02). Conclusions: Patients with operable esophageal cancer and improved responses to combined CRT and IO had distinct microbiome profiles enriched in multiple Bacteroides species. Further analyses and validation efforts are underway to confirm metabolomic pathways. Citation Format: Fyza Y. Shaikh, James R. White, Ronan J. Kelly, Ali H. Zaidi, Jenna V. Canzoniero, Josephine L. Feliciano, Russell K. Hales, K Ranh Voong, Richard J. Battafarano, Blair A. Jobe, Stephen C. Yang, Stephen Broderick, Jinny Ha, Kellie N. Smith, Elizabeth Thompson, Eun J. Shin, Ali I. Amjad, Patrizia Guerrieri, Benny Weksler, Chen Hu, Valsamo Anagnostou, Vincent K. Lam, Cynthia L. Sears. Patients with operable esophageal cancer and improved responses to combined chemoradiotherapy and immunotherapy display distinct microbiome profiles enriched in multiple Bacteroides species [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1973.

The aim of this study was to determine the effect of kemuning leaves (Murraya paniculata (L.) Jack) extract supplementation of the drinking water on performance and physical quality of egg. Twenty-four weeks old of malon hybrid quails which amounts to 240 birds were allocated in a Completely Randomized Design with four treatments and two replications. The treatments were namely P0 = control (without kemuning leaves extrct), and added kemuning leaves extract into drinking water (4 consecutive days per weeks) with dose of 3% (P1), 5% (P2) and 7% (P3). The commercial diet used in this study contained 20.01 % of crude protein. The results showed that supplementation of 3% and 7% of kemuning leaves extract into drinking water had no significant difference on performance and physical quality of egg. It was concluded that the dose of 5% kemuning leaf extract addition into total drinking water tends to produce the highest egg production (85%). Key words: Murraya paniculata (L.) Jack, performance malon quail, egg physical quality DAFTAR PUSTAKA Andari, A, Anisa EN, Wulandari RF & Suci DM. 2018. Efek suplementasi jamu rempah pada puyuh (Coturnix coturnix japonica) terhadap performa dan kadar kolesterol telur. Jurnal Ilmu Nutrisi dan Teknologi Pakan 16 (2): 34-41 Adfa, M.2007. Isolasi senyawa flavonoid aktif berkhasiat sitotoksik dari daun kemuning (Murraya paniculata L.Jack). Jurnal Gradien 3(2): 262-266 Halimah, H, Suci, DM &Wijayanti I.2019. Studi potensi penggunaan daun mengkudu (Morinda citrifolia L.) sebagi bahan antibakteri Escherichia coli dan Salmonella typhimurium. Jurnal Ilmu Pertanian Indonesia 24 (1): 56-64 Hanusova E, Hrnčár C, Hanus A, & Oravcová M. 2016. Egg traits in Japanese quail. Acta Fytotechnica et Zootechnica 19 (Special Issue) : 62-67 Hilmi,M, Sumiati & Astuti DA. 2015. Egg production and physical quality in Coturnix-coturnix Japonica fed diet containing piperine as phytogenic feed additive. Media Peternakan 38 (3): 150-155 Hrnčár C, Hanusová E, Hanus A & Bujko J. 2014. Effect of genotype on egg quality characteristic of Japanese quail (Coturnix Japonica). Slovak Journal of Animal Science 47(1): 6-11. Iskender H, Yenice G, Dokumacioglu E, Kaynar O, Hayirli A, & Kaya A. 2016. The effect of dietary flavonoid supplementation on the antioxidant status of laying hens. Brazilian Journal of Poultry Science. 18 (4): 663-668 Nowaczewski S, Kontecka H, Rosiñski A, & Koronowsk SBP. 2010. Egg quality of Japanese quail depends on layer age and storage time. Folia biologica (Kraków) 58(3-4): 201-207 Nugroho, AE, Riyanto S, Sukari MA, Maeyama K. 2010. Efek senyawa flavonoid dari kemuning (Murraya paniculata [L.] Jack terhadap pelepasan histamin dari kultur sel mast. Majalah Obat Tradisional 15 (1): 34-40 Parubak A S, 2013. Senyawa flavonoid yang bersifat antibakteri dari Akway (Drimys becariana Gibbs). Chemistry Progress 6 (1): 34-37 Prajonggo TS, DjatmikoW & Soemarno. 1983. Pengaruh Sauropus androgynus L. Merr terhadap gambaran hisotologi kelenjar susu mencit betina yang menyusui. Prosiding Kongres Nasional XI FSI. Jakarta (ID): Hlm 735-739. Saerang LP, Josephine, Yuwanta T & Nasroedin. 2000. Pengaruh minyak nabati dan lemak hewani dalam ransum puyuh petelur terhadap performa daya tetas, kadar kolesterol dan plasma darah. Buletin Peternakan 22(2):96-101 Setyaningrum S & Siregar DJS. 2015. Efektivitas minuman herbal terhadap pertumbuhan puyuh. Surya Agritama. 4:1:109-117 Siregar B. 2008. Pengaruh penambahan tepung daun singkong (Manihot utilisima crantz) dalam pakan terhadap performans produksi telur puyuh (Cortunix-cortunix japonica) petelur. Jurnal Ilmiah Ilmu-Ilmu Peternakan 11(1):28-33. Song KT, Choi SH, & Oh HR. 2000. A comparison og egg quality of pheasant, chukar, quail, and guinea fowl. Asian Australasian Journal Animal Science 13 (70): 986-990 Stojčić MD, Milošević N, Perić L, Jajić I, & Tolimir N. 2012. Egg Quality of Japanese quail in Serbia. Biotechnology in Animal Husbandry 28(3): 425-431 Subekti, S. 2007. Senyawa fitosterol dalam daun katuk (Sauropus androgynous L. Merr) dan pengaruhnya pada fungsi reproduksi puyuh. [disertasi]. Sekolah Pascasarjana: Institut Pertanian Bogor Sultana F, Islam MS & Howlider MAR. 2007. Effect of dietary Calcium sources and levels on egg production and egg shell quality of Japanese quail. International Journal of Poultry Science 6 (2): 131-136 Zainuddin D & Wibawan IWT. 2007. Biosekuriti dan Manajemen Penanganan Penyakit Ayam Lokal. Dwiyanto K, Prijono ST, editor. Bogor (ID): Pusat Penelitian Biologi LIPI. Zita L, Ledvinka Z & Klesalova L. 2013. The effect of the age of Japanese quails on certain egg quality traits and their relationships. Veterinarski Archive 83 (2) : 223-232. Yilmaz, A, Tepeli C & Çağlayan T. 2011. External and internal quality characteristics in Japanese quails of different plumage color lines. Journal of Food Agriculture and Environment 9 (2): 375-379 Yuhernita & Juniarti. 2011. Analisis senyawa metabolit sekunder dari ekstrak methanol daun Surian yang berpotensi sebagai antioksidan. Makara Sains 15(1): 48-52

IntroductionDo Not Attempt Resuscitation Orders(DNAR) and their contemporary counterparts are cornerstones of End of Life care and as such, of importance within medical education. Previous research indicates the need for a better understanding of patient and physicians perceptions of DNAR topics.Aims and methodsThe objective of the study was to explore medical students(MS) and non-medical students perspectives on DNAR discussions(DNARD), and explore any differences. This was a cross-sectional questionnaire study. MS and Education students(ES) were asked how they felt regarding DNARD taking place in 5 scenarios, a number of questions regarding previous experience, knowledge of DNARD, future preferences, and basic demographics.ResultsThe number of valid respondents was 601 (375[MS],226[ES]) representing a response rate of over 70%. There were statistically significant differences between MS and ES in the presented clinical scenarios and future preferences. Ranking of clinical scenarios, highest agreement to lowest, for DNARD to take place were: before surgery, when critically ill, at a GP appointment, on admission to hospital, at an outpatient appointment. Statistically significant demographic differences were also found: 93% of MS having heard of DNAR previously as compared to 59% of ES. Both groups held the view that a DNARD would be beneficial for them in the future but that they should have the final decision regarding DNAR.ConclusionMS and ES were found to hold differing views regarding DNARD in scenario preferences and personal future preferences. However, the majority of both groups felt that DNARD would be beneficial to them in the future.References. Mary Catherine Beach, R Sean Morrison. The Effect of Do-Not-Resuscitate Orders on Physician Decision-Making.Ethics, public policy, and medical economics2002;50:2057–206.. Cathy Charles, Tim Whelan, Amiram Gafni. 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Background. The article is devoted to studying of versatile aspects of life and work of the outstanding German pianist and composer Clara Josephine Wieck Schumann (1819–1896) on little-known in domestic musicology materials of the European scientific literature. The review of scientific sources also includes the rare works given personally to the author by the relative of Clara Schumann, Frau Hannelore Österschritt, which is the great-granddaughter of her step-brother on the mother’s side, W. Bargiel. The above large array of systematized chronological and literary sources gives an idea of the scale and aspects of studying such a scientific problem as the analysis of Clara Schumann’s creative heritage to date. It turns out that her phenomenon as a supernova on the German sky made Europeans see a woman in a different way – as a creator, a bright personality, a public figure, a successful performer. The purpose of the article is the description and systematization of European science sources, covering the figure of Clara Wieck Schumann. Research methodology are based on general scientific approaches necessary for the disclosure of the topic, including logical, historical, chronological, source-study methods needed to synthesize and systematize of scientific sources. Results. The figure of Сlara Wieck Schumann – an outstanding female composer, a successful concert pianist, a teacher, a wife, a mother and a Muse of two brilliant composers of Romanticism – was so bright that she was able to break the all previous ideas of that time about the role of a woman in society. This is evidenced by the impressive scale of the interest of researchers to her personality and creativity, the interest, which has not been extinguished in Europe for almost two centuries. Build on the literature of European scientists from different countries devoted to Clara Wieck Schumann, one can come to the conclusion that during her lifetime the work of this prominent woman was arousing the great interest of musicologists and critics (G. Schilling, F.-J. Fétis, H. Riemann), and her musical works were known and demanded. One of the most important issues that are considered in scholarly works is Clara’s personality as a representative of women who have broken the centuries-old ideas and foundations about the place of latter in society. Some of the authors (La Mara, Eva Weissweiler) tried to prove the secondary character of feminine creativity, based on cliché about that Clara Schumann herself was not always sure of the value of her musical compositions. Other researchers (F. Liszt, E. Wickop, C. Dahlhaus) argued that the work of Clara Schumann occupies a special, leading place among the history of well-known women-composers. After the death of the composer interest to her musical creativity began to fade away. Confirmation of this is almost complete absence of her works in concert programs of pianists, and even not a complete edition of the compositions of the musician. Despite this, during the twentieth century, Clara Schumann’s work continues to be carefully studied by the researchers of Germany (B. Litzmann, W. Kleefeld, K. Höcker, R. Hohenemser, A. Meurer, E. Wickop), France (R. Pitrou), England (P. Susskind, J. Chissell, N. Reich). During the last forty years, interest to Clara Wick Schumann’s creativity has grown substantially, possibly due to activation of the feminist movements in the world. Clara became one of the main objects of research about women who wrote and performed musical compositions. The culmination of this process can be called the emergence of the fundamental monograph by Janina Klassen “Clara Wieck-Schuman. Die Virtuosin als Komponistin” (1990), where the composer’s creative efforts are most fully analyzed, as well as valuable references to rare historical sources are given, including the letters from the Robert Schumann’s house in Zwickau, which have not yet been published. Conclusions. Thus, the presented large array of literary sources, being systematized by chronology and the subjects, gives an idea of the state of the studying and analysis of the cultural heritage of Clara Wieck Schumann today. The author hopes that the information collected will ease orientation in finding answers to questions arising to musicologists who explore her creativity. Summing up, we can present the generalized classification of the literature considered. So, Clara’s diaries including the records making by her father and relating to the early period of her creation, give the understanding of how the pianist’s outlook was formed. Estimative judgments about the value of composition as an important area of Clara’s creation should be sought in her epistolary heritage, in particular, in the correspondence with R. Schumann and J. Brahms. At the same place one should to look for the motives and emotional boundaries of her creativity. Answers the many questions that may arise to a performer who interprets of Clara Schumann’s music can be found in the fundamental biographical study by B. Litzmann and the articles by F. Liszt. A large layer of modern researches, which has been published since the 80s of the twentieth century, cannot be discounted as the authors rely on modern methods of analysis. Therefore, it is as if the resolved problems are being considered on a new level: from the research of forgotten pages of “XIX century women’s music” (J. Klassen), new data about Clara’s life outlook formation, and ending with issues of her music style. All these aspects give the opportunity to “collect” the creative and personal “portrait” of a genius woman of the nineteenth century.

This article documents 91 species-group names of Butterflies (Lepidoptera: Papilionoidea) for which either primary or secondary type material is present in the collections of the National Museums of Scotland, Edinburgh. The describers and the 76 nominal taxa they descibed are as follows: H. Druce (1846–1913) Euphaedra COOKSONI, Mycalesis HAROLDI; H.H. Druce (1869–1922) Cyclopides COOKSONI, Spindasis KALLIMON; H.J. Elwes (1846–1922) Parnassius delphius ssp. INFERNALIS; J.C. Fabricius (1745–1808) Papilio COCALIA (“neotype”), Papilio MARDANIA (“neotype”); H. Fruhstorfer (1866–1922) Parnassius mnemosyne ssp. MELAINA; D.R. Gifford (1918–1981) Leptomyrina HANDMANI, Alaena LAMBORNI, Deudorix (Virachola) MAGDA, Papilio ophidicephalus ssp. MKUWADZI; J.B. Godart (1775–1825) Idea AGELIA, Danais ALCATHOE, Cethosia ALIPHERA, Danais ALOPIA, Danais BAUDINIANA, Papilio BITIAS, Argynnis BRIAREA, Heliconia CLEOBAEA, Danais CLEOPHILE, Danais CLEOTHERA, Heliconia CYRBIA, Pieris DOXO, Pieris EPICHARIS, Pieris ERIPHIA, Heliconia ETHILLA, Heliconia EUCLEA, Papilio EURYMAS, Pieris GIDICA, Argynnis HEGEMONE, Satyrus HYSIUS, Papilio IMERIUS, Acraea JANISCA, Pieris JOSEPHINA, Vanessa LAODORA, Papilio LEUCASPIS, Papilio LYCORAEUS, Vanessa LYTREA, Heliconia MEGARA, Heliconia MELPHIS, Libythea MYRRHA, Acraea OZOMENE, Pieris PHISADIA, Papilio POLYMETUS, Danais PROTHOE, Argynnis PYGMAEA, Pieris PYRO, Pieris SALACIA, Acraea SERVONA, Papilio TEMENES, Papilio TEREAS, Libythea TERENA, Biblis THADANA, Argynnis THAROSSA, Papilio TRIOPAS, Pieris VENILIA, Vanessa VULCANIA, Acraea ZETHEA, Acraea ZIDORA, Acraea ZOSTERIA; C.W.N. Holmes (1916–2018) Bebearia paludicola ssp. BLANDI, Bebearia cocalioides ssp. HECQI, Bebearia orientis ssp. MALAWIENSIS, Bebearia PALUDICOLA; E.G. Honrath (1837–1893) Parnassius bremeri ssp. GRAESERI, Parnassius nordmanni var. MINIMA; W.J. Kaye (1875–1967) Hesperocharis LAMONTI; F. Moore (1830–1907) Neptis ADARA, Abisara ANGULATA, Lebadea ATTENUATA, Ixias CITRINA, Euploea LIMBORGII, Papilio ONPAPE, Cirrhochroa SURYA; W.F.H. Rosenberg & G. Talbot (1914) Dismorphia orise ssp. DENIGRATA. The secondary type material (number of species in brackets) originates from H. Carcasson (1), M. Cock (1), J. B. Godart (7), W. J. Kaye (1), O. Kudrna (3) and M. B. Usher (2).

The Czech national awakening is habitually linked with Herder’s influence as a Romantic and anti-Enlightenment happening. This study argues the opposite. It contradicts, at least in the Czech case, the idea, originally articulated by Hans Kohn, that European nationalism, particularly in the center and the east of the continent, was an expression of a particularist self-assertion, verging on (or passing into) xenophobia, and defying the rationalistic and cosmopolitan outlook of the Enlightenment. The objective of this study is, fi rst, to show that the pace-setters of the Czech national awakening functioned within the realistic rationalist Enlightenment, rather than within the emotional self-centeredness, growing out of the Romanticist ethos. They drew on other than the Herderian sources, primarily on the Josephist Enlightenment, and the subsequent liberal Catholicism, epitomized by Karl H. Seibt and Bernard Bolzano. The assumptions to the contrary were based on (1) the allegedly anti-national character of the Enlightenment; (2) a distaste for liberal Catholicism by both the offi cial Rome and the secularists; (3) an assumption of the obvious superiority of German culture; and (4) a confusion with the Slovak national romanticism.

The tribe Hygrotini Portevin, 1929 is currently composed of four genera, Heroceras Guignot, 1950, Herophydrus Sharp, 1880, Hygrotus Stephens, 1828 (with two subgenera, Coelambus Thomson, 1860, and Hygrotus s. str.), and Hyphoporus Sharp, 1880. A recent molecular phylogeny of the tribe with ca. 45% of the 137 described species of Hygrotini, including the type species of all genus-level taxa, revealed extended para- or polyphyly of the current genera and subgenera (Villastrigo et al., Zoologica Scripta, in press), for which reason a new classification of the tribe Hygrotini is proposed. Within Hygrotini only two genera are recognised: Clemnius n. gen. (with two subgenera: Clemnius s. str. with type species Hyphydrus decoratus Gyllenhal, 1810, and Cyclopius n. subgen. with type species Hydroporus acaroides LeConte, 1855) and Hygrotus (with four subgenera: Coelambus, Hygrotus s. str., Hyphoporus n. stat. and Leptolambus n. subgen. with type species Dytiscus impressopunctatus Schaller, 1783). Two genera are synonymised under Hygrotus s. str., Herophydrus n. syn. and Heroceras n. syn. The following 67 new combinations, for species thus far treated under the genera Heroceras, Herophydrus, Hygrotus and Hyphoporus, result from the new classification: Clemnius (s. str.) berneri (Young & Wolfe, 1984) n. comb., Clemnius (s. str.) decoratus (Gyllenhal, 1810) n. comb., Clemnius (s. str.) hydropicus (LeConte, 1852) n. comb., Clemnius (s. str.) laccophilinus (LeConte, 1878) n. comb., Clemnius (s. str.) sylvanus (Fall, 1917) n. comb., Clemnius (Cyclopius) acaroides (LeConte, 1855) n. comb., Clemnius (Cyclopius) farctus (LeConte, 1855) n. comb., Clemnius (Cyclopius) marginipennis (Blatchley, 1912) n. comb., Hygrotus (s. str.) assimilis (Régimbart, 1895) n. comb., H. (s. str.) bilardoi (Biström & Nilsson, 2002) n. comb., H. (s. str.) capensis (Régimbart, 1895) n. comb., H. (s. str.) confusus (Régimbart, 1895) n. comb., H. (s. str.) descarpentriesi (Peschet, 1923) n. comb., H. (s. str.) discrepatus (Guignot, 1954) n. comb., H. (s. str.) endroedyi (Biström & Nilsson, 2002) n. comb., H. (s. str.) gigantoides (Biström & Nilsson, 2002) n. comb., H. (s. str.) gigas (Régimbart, 1895) n. comb., H. (s. str.) goldschmidti (Pederzani & Rocchi, 2009) n. comb., H. (s. str.) gschwendtneri (Omer-Cooper, 1957) n. comb., H. (s. str.) hyphoporoides (Régimbart, 1895) n. comb., H. (s. str.) ignoratus (Gschwendtner, 1933) n. comb., H. (s. str.) inquinatus (Boheman, 1848) n. comb., H. (s. str.) janssensi (Guignot, 1952) n. comb., H. (s. str.) kalaharii (Gschwendtner, 1935) n. comb., H. (s. str.) morandi (Guignot, 1952) n. comb., H. (s. str.) muticus (Sharp, 1882) n. comb., H. (s. str.) natator (Biström & Nilsson, 2002) n. comb., H. (s. str.) nigrescens (Biström & Nilsson, 2002) n. comb., H. (s. str.) nodieri (Régimbart, 1895) n. comb., H. (s. str.) obscurus (Sharp, 1882) n. comb., H. (s. str.) obsoletus (Régimbart, 1895) n. comb., H. (s. str.) ovalis (Gschwendtner, 1932) n. comb., H. (s. str.) pallidus (Omer-Cooper, 1931) n. comb., H. (s. str.) pauliani (Guignot, 1950) n. comb., H. (s. str.) quadrilineatus (Régimbart, 1895) n. comb., H. (s. str.) reticulatus (Pederzani & Rocchi, 2009) n. comb., H. (s. str.) ritsemae (Régimbart, 1889) n. comb., H. (s. str.) rohani (Peschet, 1924) n. comb., H. (s. str.) rufus (Clark, 1863) n. comb., H. (s. str.) sjostedti (Régimbart, 1908) n. comb., H. (s. str.) spadiceus (Sharp, 1882) n. comb., H. (s. str.) sudanensis (Guignot, 1952) n. comb., H. (s. str.) travniceki (Šťastný, 2012) n. comb., H. (s. str.) tribolus (Guignot, 1953) n. comb., H. (s. str.) variabilis secundus (Régimbart, 1906) n. comb., H. (s. str.) variabilis variabilis (Guignot, 1954) n. comb., H. (s. str.) verticalis (Sharp, 1882) n. comb., H. (s. str.) vittatus (Régimbart, 1895) n. comb., H. (s. str.) wewalkai (Biström & Nilsson, 2002) n. comb., Hygrotus (Hyphoporus) anitae (Vazirani, 1969) n. comb., H. (Hyphoporus) aper (Sharp, 1882) n. comb., H. (Hyphoporus) bengalensis (Severin, 1890) n. comb., H. (Hyphoporus) bertrandi (Vazirani, 1969) n. comb., H. (Hyphoporus) caliginosus (Régimbart, 1899) n. comb., H. (Hyphoporus) dehraduni (Vazirani, 1969) n. comb., H. (Hyphoporus) elevatus (Sharp, 1882) n. comb., H. (Hyphoporus) geetae (Vazirani, 1969) n. comb., H. (Hyphoporus) josephi (Vazirani, 1969) n. comb., H. (Hyphoporus) kempi (Gschwendtner, 1936) n. comb., H. (Hyphoporus) montanus (Régimbart, 1899) n. comb., H. (Hyphoporus) nilghiricus (Régimbart, 1903) n. comb., H. (Hyphoporus) oudomxai (Brancucci & Biström, 2013) n. comb., H. (Hyphoporus) pacistanus (Guignot, 1959) n. comb., H. (Hyphoporus) pugnator (Sharp, 1890) n. comb., H. (Hyphoporus) severini (Régimbart, 1892) n. comb., H. (Hyphoporus) subaequalis (Vazirani, 1969) n. comb., H. (Hyphoporus) tonkinensis (Régimbart, 1899) n. comb.

The purpose of the article is to analyze B. Bolzano’s doctrine of the highest moral law. To achieve this goal, the following tasks are solved: the variants of justification of the supreme moral law proposed by Bolzano are investigated; the context in which Bolzano’s ethical views were formed is clarified; finally, the Bolzano’s doctrine is compared with Kant’s theory of the categorical imperative. The methods of rational reconstruction and historical-philosophical comparisons are used. The article consists of six sections. The first section talks about the role that the doctrine of the highest moral principle played in the philosophy of Bolzano. In the second section, two possible formulations of the supreme moral law are proposed and two variants of the justification of these formulations found in the works of Bolzano are examined — “subjective” and “objective” justification. The third section clarifies the context: it talks about the influence of Bohemian Josephism on the philosophy of Bolzano, two ethical teachings are considered separately: the practical ethics of K. H. Seibt and the moral theology of A. Zippe. The fourth section deals with Bolzano’s criticism of some aspects of the ethical teachings of the Enlightenment: Bolzano believed that hedonism could not be the cornerstone of the doctrine of morals, and he found the moral theologians’ conception of the status of practical truths incorrect. The fifth section gives the assessment that Bolzano gave to Kant’s ethics, and also analyzes separately the reasons why Bolzano criticized Kant’s formulations of the categorical imperative. Finally, the sixth section clarifies some of the theses of the ethical theory of Bolzano, and also shows that the Bolzanian version of utilitarianism is able to cope with some of the problems of Kantian ethics.

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Menstrual Patterns and Problems among adolescent girls in rural areas. International Journal of Biomedical and Advance Research. 2013; 4(8):551–

BackgroundWhile protection against pertussis following maternal tetanus-diphtheria-and-acellular-pertussis (Tdap) vaccination has been demonstrated in term-born infants from healthy mothers[1], no evidence is available on Tdap vaccination in combination with immune-modulating therapy during pregnancy.ObjectivesIn this pilot-study, we explored whether treatment with Tumor Necrosis Factor alpha inhibitors (TNFis) in pregnant patients with rheumatic disease interferes with Tdap vaccine responses and/or affects maternal IgG antibody concentrations against the relevant antigens in the newborns.MethodsPatients included by a rheumatologist during pregnancy received a Tdap vaccination in their late-second or early-third trimester. Blood samples were drawn during the first trimester, three months after delivery and from the umbilical cord. IgG antibody levels against Tdap-included antigens were measured using a bead-based multiplex immunoassay. Findings on patients exposed to TNFis were compared with those from TNFi-unexposed patients and with data from a historical comparator study among healthy Tdap vaccinated mother-infant-pairs (n=53). [2]Results66 patients (46 exposed and 20 unexposed to TNFIs) were enrolled. No differences in IgG antibody levels against Tdap-included antigens were observed between TNFi-exposed and unexposed patients before and after Tdap vaccination (Figure 1). In cord sera however, antibody levels against pertussis toxin were significantly lower after TNFi-treatment (35.94IU/mL, 95%CI 20.68-62.45) compared with no TNFis (94.61IU/mL, 95%CI 48.89-183.07) and with cord blood from the comparison cohort of healthy women-infant-pairs (125.12IU/mL, 95%CI 90.75-172.50). We observed similar differences for filamentous hemagglutinin, pertactin, tetanus toxoid, and diphtheria toxoid.ConclusionThese preliminary data indicate no reduced IgG antibody response upon maternal Tdap vaccination in pregnant women following immune-modulating treatment, although our findings suggest that TNFis during pregnancy induce lower maternal antibody levels against Tdap-included antigens in newborns.References[1] Byrne L, Campbell H, Andrews N, Ribeiro S, Amirthalingam G. Hospitalisation of preterm infants with pertussis in the context of a maternal vaccination programme in England. Arch Dis Child. 2018;103(3):224-9.[2] Barug D, Pronk I, van Houten MA, Versteegh FGA, Knol MJ, van de Kassteele J, et al. Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial. Lancet Infect Dis. 2019;19(4):392-401.Figure 1.Anti-Pertussis toxin (anti-PT IgG) concentrations (IU/mL) before and after vaccination and in cord sera, represented for women exposed or unexposed to TNFis, or healthy pregnant women, including their offspring. X-axis: type and time-point of blood sample draw. Y-axis: IgG antibody concentration against pertussis toxin (IU/mL). Significance *p<0.05, **p<0.01, ***p<0.001.Acknowledgements:NIL.Disclosure of InterestsNafise Ghalandari Grant/research support from: Financial support for printing PhD book from UCB Pharma., Employee of: From June 2022 till February 2023 worked as a medical science liaison (MSL) at UCB Pharma., Maarten Immink: None declared, Esther Röder: None declared, Patricia Bruijning-Verhagen: None declared, Hieronymus TW Smeele: None declared, Hubertina Johanna Maria Josephina Crijns: None declared, Nicoline van der Maas: None declared, Mireille Bekker: None declared, Lieke Sanders: None declared, Radboud Dolhain Speakers bureau: from AbbVie, AstraZeneca, Eli Lily, Galapagos, Novartis, Roche, UCB., Grant/research support from: an unrestricted grant from Galapagos, UCB Pharma B.V.

https://doi.org/10.14814/phy2.15627 The above article, published online on 10 March 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Josephine C. Adams, The Physiological Society and American Physiological Society, and John Wiley and Sons Ltd. The retraction has been agreed at the authors' request. Since publication, the authors have identified that the calculation of microcirculatory resistance does not require a correction factor. This invalidates several figures in the paper and the overall conclusions. The editors have no ethical concerns about the paper. The authors have prepared a Letter to the Editor (10.14814/phy2.15807) explaining, in detail, the error and their decision to retract the paper.

Habenaria qinghaiensis, a new species of Orchidaceae from Qinghai Province, is described and illustrated. Molecular phylogenetic analysis based on nuclear ITS (nrITS) and two plastid (matK and rbcL) DNA markers indicates that H. qinghaiensis belongs to H. josephi group (sect. Diphyllae s.l.). It is morphologically similar to H. josephi and H. tibetica, but differs from the former by having petals shallowly 2-lobed at base, lateral lobes of lip 1.8–2.2 cm long, lip with cushion-like appendage at entrance of spur, and from the latter by having almost glabrous bracts, petals and ovary, lip with cushion-like appendage at entrance of spur, and three stigmas.

The structure of the cumacean assemblages from the southern margin of the Cap Ferret Canyon was studied at 13 stations ranging from 346 to 1099 m depth with a modified Macer-GIROQ suprabenthic sledge (four superimposed nets; 0.5 mm mesh size). A total of 1885 specimens were collected and classified into 5 families and 42 species. The total abundances fluctuated between 2.8 ind./100 m2 (station TS04; 484-485 m) and 55.8 ind./100 m2 (station TS08; 714-708 m). The highest values of species richness and diversity were recorded at station TS13 (1097-1099 m): S=25 species; H’(log2)=4.05. The near-bottom vertical distribution of the cumacean fauna showed the same pattern at all stations: at least 60% of the individu­als were sampled by the lower net of the sledge and a drastic abundance decrease occurred between the two lowermost water layers sampled by the sledge. The multivariate analysis carried out on abundance data discriminated three main groups of stations distributed across depth (TS09 excluded): group Ia (346-485 m) characterized by the dominance of Nannastacidae (57.2%) at family level and Campylaspis sulcata, Leptostylis macrura at species level; group Ib (522-714 m) characterized by the dominance of Nannastacidae (66.1%) at family level and Campylaspis squamifera, C. laevigata and Leptostylis ma­crura at species level; and group II (790-1099 m) characterized by the dominance of Diastylidae (40.3%) at family level and Makrokylindrus (Adiastylis) josephinae, Leucon (Epileucon) pusillus and Diastyloides serratus at species level. According to this analysis, the main faunal change occurs between group I and II between 714 and 790 m, in relation to changes in the texture of surficial sediments. Although bathyal cumacean assemblages appear to be less abundant than those studied on continental shelves, they are significantly more diverse. However, such results could be in part related to the use of different sampling methods.

IntroductionThree broad stages of Australia’s arts and culture sectors may be discerned with reference to the Northern Hemisphere. The first is in Australia’s early years where artists travelled to the metropoles of Europe to learn from acknowledged masters, to view the great works and to become part of a broader cultural scene. The second is where Australian art was promoted internationally, which to some extent began in the 1960s with exhibitions such as the 1961 ‘Survey of recent Australian painting’ at the Whitechapel gallery. The third relates to the strong promotion and push to display and sell Indigenous art, which has been a key area of focus since the 1970s.The Allure of the NorthFor a long time Australasian artists have mostly travelled to Britain (Britain) or Europe (Cooper; Frost; Inkson and Carr), be they writers, painters or musicians for example. Hecq (36) provides a useful overview of the various periods of expatriation from Australia, referring to the first significant phase at the end of the twentieth century when many painters left “to complete their atelier instruction in Paris and London”. Many writers also left for the north during this time, with a number of women travelling overseas on account of “intellectual pressures as well as intellectual isolation”(Hecq 36). Among these, Miles Franklin left Australia in “an open act of rebellion against the repressive environment of her family and colonial culture” (37). There also existed “a belief that ‘there’ is better than ‘here’” (de Groen vii) as well as a “search for the ideal” (viii). World War I led to stronger Anglo-Australian relations hence an increase in expatriation to Europe and Britain as well as longer-term sojourns. These increased further in the wake of World War II. Hecq describes how for many artists, there was significant discontent with Australian provincialism and narrow-mindedness, as well as a desire for wider audiences and international recognition. Further, Hecq describes how Europe became something of a “dreamland”, with numerous artists influenced by their childhood readings about this part of the world and a sense of the imaginary or the “other”. This sense of a dream is described beautifully by McAuliffe (56), who refers to the 1898 painting by A.J. Daplyn as a “melancholic diagram of the nineteenth-century Australian artist’s world, tempering the shimmering allure of those northern lights with the shadowy, somnolent isolation of the south”.Figure 1: The Australian Artist’s Dream of Europe; A.J. Daplyn, 1898 (oil on canvas; courtesy artnet.com)In ‘Some Other Dream’, de Groen presents a series of interviews with expatriate Australian artists and writers as an insight into what drove each to look north and to leave Australia, either temporarily or permanently. Here are a few examples:Janet Alderson: “I desperately wanted to see what was going on” (2)Robert Jacks: “the dream of something else. New York is a dream for lots of people” (21)Bruce Latimer: “I’d always been interested in America, New York in particular” (34)Jeffrey Smart: “Australia seemed to be very dull and isolated, and Italy seemed to be thrilling and modern” (50)Clement Meadmore: “I never had much to do with what was happening in Melbourne: I was never accepted there” (66)Stelarc: “I was interested in traditional Japanese art and the philosophy of Zen” (80)Robert Hughes: “I’d written everything that I’d wanted to write about Australian art and this really dread prospect was looming up of staying in Australia for the rest of one’s life” (128)Max Hutchison: “I quickly realised that Melbourne was a non-art consuming city” (158)John Stringer: “I was not getting the latitude that I wanted at the National Gallery [in Australia] … the prospects of doing other good shows seemed rather slim” (178)As the testimony here suggests, the allure of the north ranges from dissatisfaction with the south to the attraction of various parts of the world in the north.More recently, McAuliffe describes a shift in the impact of the overseas experience for many artists. Describing them as business travellers, he refers to the fact that artists today travel to meet international art dealers and to participate in exhibitions, art fairs and the like. Further, he argues that the risk today lies in “disorientation and distraction rather than provincial timidity” (McAuliffe 56). That is, given the ease and relatively cheap costs of international travel, McAuliffe argues that the challenge is in adapting to constantly changing circumstances, rather than what are now arguably dated concepts of cultural cringe or tyranny of distance. Further, given the combination of “cultural nationalism, social cosmopolitanism and information technology”, McAuliffe (58) argues that the need to expatriate is no longer a requirement for success.Australian Art Struggles InternationallyThe struggles for Australian art as a sector to succeed internationally, particularly in Britain, Europe and the US, are well documented (Frost; Robertson). This is largely due to Australia’s limited history of white settlement and established canon of great art works, the fact that power and position remain strong hence the dominance of Europe and North America in the creative arts field (Bourdieu), as well as Australia’s geographical isolation from the major art centres of the world, with Heartney (63) describing the “persistent sense of isolation of the Australian art world”. While Australia has had considerable success internationally in terms of its popular music (e.g. INXS, Kylie Minogue, The Seekers) and high-profile Hollywood actors (e.g. Geoffrey Rush, Hugh Jackman, Nicole Kidman), the visual arts in particular have struggled (O’Sullivan), including the Indigenous visual arts subsector (Stone). One of the constant criticisms in the visual art world is that Australian art is too focussed on place (e.g. the Australian outback) and not global art movements and trends (Robertson). While on the one hand he argues that Australian visual artists have made some inroads and successes in the international market, McAuliffe (63) tempers this with the following observation:Australian artists don’t operate at the white-hot heart of the international art market: there are no astronomical prices and hotly contested bidding wars. International museums acquire Australian art only rarely, and many an international survey exhibition goes by with no Australian representation.The Push to Sell Australian Cultural Product in the NorthWriting in the mid-nineties at the time of the release of the national cultural policy Creative Nation, the then prime minister Paul Keating identified a need for Australia as a nation to become more competitive internationally in terms of cultural exports. This is a theme that continues today. Recent decades have seen several attempts to promote Australian visual art overseas and in particular Indigenous art; this has come with mixed success. However, there have been misconceptions in the past and hence numerous challenges associated with promoting and selling Aboriginal art in international markets (Wright). One of the problems is that a lot of Europeans “have often seen bad examples of Aboriginal Art” (Anonymous 69) and it is typically the art work which travels north, less so the Indigenous artists who create them and who can talk to them and engage with audiences. At the same time, the Indigenous art sector remains a major contributor to the Australian art economy (Australia Council). While there are some examples of successful Australian art managers operating galleries overseas in such places as London and in the US (Anonymous-b), these are limited and many have had to struggle to gain recognition for their artists’ works.Throsby refers to the well-established fact that the international art market predominantly resides in the US and in Europe (including Britain). Further, Throsby (64) argues that breaking into this market “is a daunting task requiring resources, perseverance, a quality product, and a good deal of luck”. Referring specifically to Indigenous Australian art, Throsby (65) reveals how leading European fairs such as those at Basel and Cologne, displaying breath-taking ignorance if not outright stupidity, have vetoed Aboriginal works on the grounds that they are folk art. This saga continues to the present day, and it still remains to be seen whether these fairs will eventually wake up to themselves.It is also presented in an issue of Artlink that the “challenge is to convince European buyers of the value of Australian art, even though the work is comparatively inexpensive” (Anonymous 69). Is the Rite of Passage Relevant in the 21st Century?Some authors challenge the notion that the rite of passage to the northern hemisphere is a requirement for success for an Australian artist (Frost). This challenge is worthy of unpacking in the second decade of the twenty-first century, and particularly so in what is being termed the Asian century (Bice and Sullivan; Wesley). Firstly, Australia is far closer to Asia than it is to Europe and North America. Secondly, the Asian population is expected to continue to experience rapid economic and population growth, for example the rise of the middle class in China, potentially representing new markets for the consumption of creative product. Lee and Lim refer to the rapid economic modernisation and growth in East Asia (Japan to Singapore). Hence, given the struggles that are often experienced by Australian artists and dealers in attempting to break into the art markets of Europe and North America, it may be more constructive to look towards Asia as an alternative north and place for Australian creative product. Fourthly, many Asian countries are investing heavily in their creative industries and creative economy (Kim and Kim; Kong), hence representing an opportune time for Australian creative practitioners to explore new connections and partnerships.In the first half of the twentieth century, Australians felt compelled to travel north to Europe, especially, if they wanted to engage with the great art teachers, galleries and art works. Today, with the impact of technology, engaging with the art world can be achieved much more readily and quickly, through “increasingly transnational forms of cultural production, distribution and consumption” (Rowe et al. 8). This recent wave of technological development has been significant (Guerra and Kagan), in relation to online communication (e.g. skype, email), social media (e.g. Facebook, Twitter) as well as content available on the Web for both informal and formal learning purposes. Artists anywhere in the world can now connect online while also engaging with what is an increasing field of virtual museums and galleries. For example, the Tate Gallery in London has over 70,000 artworks in its online art database which includes significant commentary on each work. While online engagement does not necessarily enable an individual to have the lived experience of a gallery walk-through or to be an audience member at a live performance in an outstanding international venue, online technologies have made it much easier for developing artists to engage from anywhere in the world. This certainly makes the ‘tyranny of distance’ factor relevant to Australia somewhat more manageable.There is also a developing field of research citing the importance of emerging artists displaying enterprising and/or entrepreneurial skills (Bridgstock), in the context of a rapidly changing global arts sector. This broadly refers to the need for artists to have business skills, to be able to seek out and identify opportunities, as well as manage multiple projects and/or various streams of income in what is a very different career type and pathway (Beckman; Bridgstock and Cunningham; Hennekam and Bennett). These opportunity seeking skills and agentic qualities have also been cited as critical in relation to the fact that there is not only a major oversupply of artistic labour globally (Menger), but there is a growing stream of entrants to the global higher education tertiary arts sector that shows no signs of subsiding (Daniel). Concluding RemarksAustralia’s history features a strong relationship with and influences from the north, and in particular from Britain, Europe and North America. This remains the case today, with much of Australian society based on inherited models from Britain, be this in the art world or in such areas as the law and education. As well as a range of cultural and sentimental links with this north, Australia is sometimes considered to be a satellite of European civilisation in the Asia-Pacific region. It is therefore explicable why artists might continue this longstanding relationship with this particular north.In our interesting and complex present of the early twenty-first century, Australia is hampered by the lack of any national cultural policy as well as recent significant cuts to arts funding at the national and state levels (Caust). Nevertheless, there are opportunities to be further explored in relation to the changing patterns of production and consumption of creative content, the impact of new and next technologies, as well as the rise of Asia in the Asian Century. The broad field of the arts and artists is a rich area for ongoing research and inquiry and ultimately, Australia’s links to the north including the concept of the rite of passage deserves ongoing consideration.ReferencesAnonymous a. "Outposts: The Case of the Unofficial Attache." Artlink 18.4 (1998): 69–71.Anonymous b. "Who’s Selling What to Whom: Australian Dealers Taking Australian Art Overseas." Artlink 18. 4 (1998): 66–68.Australia Council for the Arts. Arts Nation: An Overview of Australian Arts. 2015. <http://www.australiacouncil.gov.au/workspace/uploads/files/arts-nation-final-27-feb-54f5f492882da.pdf>.Beckman, Gary D. "'Adventuring' Arts Entrepreneurship Curricula in Higher Education: An Examination of Present Efforts, Obstacles, and Best Practices." The Journal of Arts Management, Law, and Society 37.2 (2007): 87–112.Bice, Sara, and Helen Sullivan. "Abbott Government May Have New Rhetoric, But It’s Still the ‘Asian Century’." The Conversation 2013. <https://theconversation.com/abbott-government-may-have-new-rhetoric-but-its-still-the-asian-century-19769>.Bourdieu, Pierre. Distinction: A Social Critique of the Judgement of Taste. Routledge & Kegan Paul, 1984.Bridgstock, Ruth. "Not a Dirty Word: Arts Entrepreneurship and Higher Education." Arts and Humanities in Higher Education 12.2–3 (2013,): 122–137. doi:10.1177/1474022212465725.———, and Stuart Cunningham. "Creative Labour and Graduate Outcomes: Implications for Higher Education and Cultural Policy." International Journal of Cultural Policy 22.1 (2015): 10–26. doi:10.1080/10286632.2015.1101086.Britain, Ian. Once an Australian: Journeys with Barry Humphries, Clive James, Germaine Greer and Robert Hughes. Oxford: Oxford UP, 1997.Caust, Josephine. "Cultural Wars in an Australian Context: Challenges in Developing a National Cultural Policy." International Journal of Cultural Policy 21.2 (2015): 168–182. doi:10.1080/10286632.2014.890607.Cooper, Roslyn Pesman. "Some Australian Italies." Westerly 39.4 (1994): 95–104.Daniel, Ryan, and Robert Johnstone. "Becoming an Artist: Exploring the Motivations of Undergraduate Students at a Regional Australian University". Studies in Higher Education 42.6 (2017): 1015-1032.De Groen, Geoffrey. Some Other Dream: The Artist the Artworld & the Expatriate. Hale & Iremonger, 1984.Frost, Andrew. "Do Young Australian Artists Really Need to Go Overseas to Mature?" The Guardian, 9 Oct. 2013. <https://www.theguardian.com/culture/australia-culture-blog/2013/oct/09/1https://www.theguardian.com/culture/australia-culture-blog/2013/oct/09/1, July 20, 2016>.Guerra, Paula, and Sacha Kagan, eds. Arts and Creativity: Working on Identity and Difference. Porto: University of Porto, 2016.Heartney, Eleanor. "Identity and Locale: Four Australian Artists." Art in America 97.5 (2009): 63–68.Hecq, Dominique. "'Flying Up for Air: Australian Artists in Exile'." Commonwealth (Dijon) 22.2 (2000): 35–45.Hennekam, Sophie, and Dawn Bennett. "Involuntary Career Transition and Identity within the Artist Population." Personnel Review 45.6 (2016): 1114–1131.Inkson, Kerr, and Stuart C. Carr. "International Talent Flow and Careers: An Australasian Perspective." Australian Journal of Career Development 13.3 (2004): 23–28.Keating, P.J. "Exports from a Creative Nation." Media International Australia 76.1 (1995): 4–6.Kim, Jeong-Gon, and Eunji Kim. "Creative Industries Internationalization Strategies of Selected Countries and Their Policy Implications." KIEP Research Paper. World Economic Update-14–26 (2014). <https://ssrn.com/abstract=2488416>.Kong, Lily. "From Cultural Industries to Creative Industries and Back? Towards Clarifying Theory and Rethinking Policy." Inter-Asia Cultural Studies 15.4 (2014): 593–607.Lee, H., and Lorraine Lim. Cultural Policies in East Asia: Dynamics between the State, Arts and Creative Industries. Springer, 2014.McAuliffe, Chris. "Living the Dream: The Contemporary Australian Artist Abroad." Meanjin 71.3 (2012): 56–61.Menger, Pierre-Michel. "Artistic Labor Markets and Careers." Annual Review of Sociology 25.1 (1999): 541–574.O’Sullivan, Jane. "Why Australian Artists Find It So Hard to Get International Recognition." AFR Magazine, 2016.Robertson, Kate. "Yes, Capon, Australian Artists Have Always Thought about Place." The Conversation, 2014. <https://theconversation.com/yes-capon-australian-artists-have-always-thought-about-place-31690>.Rowe, David, et al. "Transforming Cultures? From Creative Nation to Creative Australia." Media International Australia 158.1 (2016): 6–16. doi:10.1177/1329878X16629544.Stone, Deborah. "Presenters Reject Indigenous Arts." ArtsHub, 2016. <http://www.artshub.com.au/news-article/news/audience-development/deborah-stone/presenters-reject-indigenous-arts-252075?utm_source=ArtsHub+Australia&utm_campaign=7349a419f3-UA-828966-1&utm_medium=email&utm_term=0_2a8ea75e81-7349a419f3-302288158>.Throsby, David. "Get Out There and Sell: The Visual Arts Export Strategy, Past, Present and Future." Artlink 18.4 (1998): 64–65.Wesley, Michael. "In Australia's Third Century after European Settlement, We Must Rethink Our Responses to a New World." The Conversation, 2015. <https://theconversation.com/in-australias-third-century-after-european-settlement-we-must-rethink-our-responses-to-a-new-world-46671>.Wright, Felicity. "Passion, Rich Collectors and the Export Dollar: The Selling of Aboriginal Art Overseas." Artlink 18.4 (1998): 16.

Introduction Within wellness circles, there has been growing concern over an increasing focus on Alternative Right (or Alt-right) conspiracy (see Aubry; Bloom and Moskalenko). Greene, referring to a definition provided by the Anti-Defamation League, defines the Alt-right as a loose political network characterised by its rejection of mainstream conservatism, embrace of white nationalism, and use of online platforms (33). The “wellness revolution”, on the other hand, which marked a split from the health care sector in which “thought leaders” replaced medical experts as authorities on health (Pilzer, qtd. in Kickbusch and Payne 275), combines New Age practices with ideological movements that emphasise the “interdependence of body, mind and spirit” (Voigt and Laing 32). It has been noted that there is overlap between the circulation of conspiracy theory and New Age mysticism (see Ward and Voas; Parmigiani). Influencers following the Paleo diet, or Palaeolithic diet, such as Australian celebrity chef and Paleo diet guru Pete Evans, have also come under fire for sharing conspiracy theories and pseudoscience (see Brennan). Johnson notes that the origins of the Paleo diet can be traced back to 1975, with the publication of Dr Walter Voegtlin’s book The Stone Age Diet. This text, however, has been largely disavowed by Paleo leaders due to Voegtlin’s “white supremacist, eugenicist, and generally unpalatable politics”. Nevertheless, it is interesting to consider how white nationalism and conspiracy theory may overlap within the wellness space. A specific example occurred in 2020, when Pete Evans shared an Alt-right conspiracy meme to his Facebook account. The ‘butterfly-caterpillar meme’ contained the image of a black sun, a symbol equated with the swastika (Goodrick-Clarke 3). Though Evans later commented that the sharing of the hate symbol was unintentional, and that he misunderstood the symbol, this case raised questions about the ability of wellness influencers to amplify white nationalist messaging. This essay is concerned with the question: what makes the wellness industry a target for the spreading of white nationalist ideas? It argues that the wellness industry and far-right ideology possess a pre-occupation with bodily purity which makes it more likely that white nationalist material carrying this message will be spread via wellness networks. Through a critical examination of the media surrounding Evans’s sharing of the butterfly-caterpillar meme, this case study will examine the ideological aspects of the Paleo diet and how they appeal to a white nationalist agenda. Focussing on the Australian context, this essay will theorise the spreadability of memes in relation to white nationalist symbolism. It contends that the Paleo diet positions foods that are not organic as impure, and holds a preference for positive messaging. Alt-right propaganda packaged in a positive and New Age frame poses a danger in that it can operate as a kind of contagion for high-profile networks, exponentially increasing its spreadability. This is of particular concern when it is considered that diet can have an impact on people’s actions outside of the online space: it impacts what people consume and do with their bodies, as evidenced by calls for eating disorders created by algorithmic repetition to be considered a ‘cyber-pathy’. This creates the conditions for the wellness industry to be targeted using memes as recruitment material for white nationalist groups. The Paleo Diet and the Sharing of a Neo-Nazi Meme Pete Evans is a famous Australian TV Chef from the hit series My Kitchen Rules, a show that ran from 2010-2020. The show followed pairs from different households as they cooked for Evans and his co-host Manu Feildel. During the show’s run, Evans also became known for spruiking the Paleo diet, producing several cookbooks and a documentary on the topic. According to Catie Gressier, who conducted a study of Paleo dieters in Melbourne, Paleo’s aim is “to eat only those foods available prior to the agricultural revolution: meat, fish, vegetables, nuts, seeds and a small amount of fruit” and that this framed as a more “authentic” diet (3). This is seen as an ideological diet as opposed to others which may consist of rules or eating restrictions. The Paleo diet stresses “real foods” or “organic foods as close to their real state as possible” (Ramachandran et al.). Studies find that the paleo diet can be very nutritious (Cambeses-Franco et al. 2021). However, it is important to note that the presence of multiple influencers and thought leaders in the field means that there can be several variations in the diet. This article will limit its examination to that of the diet promoted by Evans. A common rationale is that the human body is incompatible with certain mass-produced foods (like grains, pulses, and dairy products, sugar, salt, and modification practices (like food processing), and that these are the cause of many modern conditions (Cambeses-Franco et al. 2021). While growing concerns over unnatural additives in foods are warranted, it can be observed that in Evans’s case, the promotion of the Paleo diet increasingly blurred the line between pseudoscience and conspiracy. In his Paleo diet book for toddlers, Evans emphasised the importance of the ideological diet and suggested that parents feed their toddlers bone broth instead of breast milk, prompting a federal investigation by the health department (Brennan). This escalated in 2020 during the global pandemic. In January, Evans promoted the work of a prominent anti-vaccine advocate (Molloy). In April, his Biocharger device, which he claimed could cure coronavirus, earned him a hefty fine from the Therapeutic Goods Administration (White). In November, several months after My Kitchen Rules was cancelled, Evans posted an Alt-right political cartoon with the image of a black sun, a symbol equated with the swastika (Goodrick-Clarke 3), to his Facebook account (Gillespie). In later news reports, it was also pointed out that the black sun symbol was emblazoned on the backpack of the Christchurch shooter (see Sutton and Molloy) who had targeted two mosques in Christchurch, New Zealand, killing 51 people and injuring 40. Initially, when a user on Facebook pointed out that the meme contained a black sun, Evans responded “I was waiting for someone to see that” (Evans, qtd. in Gillespie). Evans eventually recanted the image, writing: sincere apologies to anyone who misinterpreted a previous post of a caterpillar and a butterfly having a chat over a drink and perceived that I was promoting hatred. I look forward to studying every symbol that have ever existed and research them thoroughly before posting. Hopefully this symbol ❤️ resonates deeply into the hearts of ALL! (Evans, qtd. in Gillespie). The post was later deleted. In December of 2020, Evans’s Facebook page of around 1.5 million followers was removed due to its sharing of conspiracy theories and misinformation about the coronavirus (Gillespie). However, it should be noted that the sharing of the caterpillar-butterfly meme was different from the previous instances of conspiracy sharing, in that Evans stated that it was unintentional, and it included imagery associated with neo-Nazi ideology (the black sun). Evans’s response implies that, while the values of the Paleo diet are framed in terms of positivity, the symbols in the butterfly-caterpillar meme are associated with “promoting hatred”. In this way, Evans frames racism as merely and simplistically an act of hatred, rather than engaging in the ways in which it reinforces a racial hierarchy and racially motivated violence. According to Hartzell (10), white nationalists tend to position themselves as superior to other races and see themselves as protectors of the “white race”. “White” in this context is of European descent (Geary, Schofield and Sutton). There are conspiracy theories associated with this belief, one of which is that their race is under threat of extinction because of immigration from ‘undesirable’ countries of origin. This can also be observed in the Alt-right, which is a white nationalist movement that was created and organised online. According to Berger, this movement “seeks to unify the activities of several different extremist movements or ideologies”. This is characterised by anti-immigrant sentiment, conspiracy theories, and support for former US President Donald Trump. It can be argued, in this case, that the symbol links to a larger conspiracy theory in which whiteness must be defended against some perceived threat. The meme implies that there is an ‘us’ versus ‘them’, or ‘good’ versus ‘evil’, and that some people are ‘in the know’ while others are not. Spreadable Memes An important aspect of this case study is that this instance of far-right recruitment used the form of a meme. Memes are highly spreadable, and they have very complex mechanisms for disseminating ideas and ideology. This can have a dramatic impact if that ideology is a harmful one, such a white supremacist symbol. While the digital meme, an image with a small amount of text, is common today, Richard Dawkins originally used the term meme to describe the ways in which units of culture can be spread from person to person (qtd. in Shifman 9). These can be anything from the lyrics of a song to a political idea. Jeff Hemsley and Robert Mason (qtd. in Shifman) see virality as a “process wherein a message is actively forwarded from one person to other, within and between multiple weakly linked personal networks, resulting in a rapid increase in the number of people who are exposed to the message” (55). This also links to Jenkins, Ford, and Green’s notions of spreadability (3-11), a natural selection process by which media content continues to exist through networked sharing, or disappears once it stops being shared. Evans’s response indicates that he merely shared the image. Despite the black sun imagery, a Make America Great Again (MAGA) hat is clearly present. A political presence, and one that is associated with white nationalism, is present despite Evans’s attempts to frame the meme in the language of innocence and positivity. This is not to say Evans is extremist or supports a white nationalist agenda. However, in much the same way that sharing of imagery may not necessarily indicate agreement with its ideological messaging, this framing creates a way in which wellness influencers may avoid criticism (Ma 1). Furthermore, the act of sharing the meme, regardless of intention, amplifies its message exponentially. The Paleo Diet, the Far Right and Purity This overlap between wellness and white nationalist ideology is not new. In Jules Evans’s exploration of why QAnon is popular with New Age and far-right followers, she points to the fact that many Nazi leaders – Hitler, Hess, Himmler – “were into alternative medicine, organic and vegetarian diets, homeopathy, anti-vaxxing, and natural healing”. Similarly, Bernhard Forchtner and Ana Tominc argue that a natural diet which focussed on food purity was favoured by the Nazis (421). In their examination of the German neo-Nazi YouTube channel Balaclava Küche they argue add that “present-day extreme right views on environment and diet are often close to positions found in contemporary Green movements and foodie magazines” (422). Like neo-Nazi preoccupations with food, the Paleo diet’s ideology has its basis in the concept of purity. Gressier found that the Paleo diet contains an “embedded moralism” that “filters into constructions of food as either pure or polluting” (1). This is supported by Ramachandran et al.’s study, which found that the diet “promoted ‘real food’ – or the shift to consuming organic whole foods that are as close to their natural state as possible, with an avoidance of processed foods”. This framing of the food as real creates a binary – if one is real, the other must not be. Another example can be seen in Pete Evans’s Webpage, which lists about 33 Paleo recipes. The Butter Chicken recipe states: the paleo way of life is not meant to be restrictive, as you can see from this lovely butter chicken recipe. All the nasties have been replaced with good-quality ingredients that make it as good, if not better, than the original. I prefer chicken thighs for their superior flavour and tenderness. The term “nasties” here can be seen to create a dichotomy between real and fake, the west and the east. We see these foods are associated with impurity, the foods that are not “real foods” are positioned as a threat. It can be seen as an orientalist approach, othering those not associated with the west. As can be observed in this Butter Chicken recipe that is “getting rid of the nasties”, it appropriates and ‘sanitises’ ingredients. In her article on the campaign to boycott Halal, Shakira Hussein points out that “ethnic food” presents as multiculturalism in the context of white chefs and homecooks, but the opposite is true if the roles are switched (91). Later in her essay “Halal Chops and Fascist Cupcakes”, she discusses the “weaponisation of food” and how specific white nationalist groups express disgust at the thought of consuming Muslim food. This ethnocentric framing of butter chicken projects a western superiority, replacing traditional ingredients with ‘familiar’ ingredients, making it more palatable to nationalistic tastes. Spreading Consumption I have established that the Paleo diet, with its emphasis on ‘real foods’, is deeply embedded with nationalist ideology. I have also discussed how this is highly spreadable in the form of a meme, particularly when it is framed in the language of positivity. Furthermore, I have argued that this is an attempt to escape criticism for promoting white nationalist values. I would like to turn now to how this spreadability through diet can have an impact on the physical actions of its followers through its digital communication. The Paleo diet, and how to go about following it as described by celebrity influencers, has an impact on what people do with their bodies. Hanganu-Bresch discusses the concept of orthorexia, a fixation with eating proper foods that operates as a cyber-pathy, a digitally propagated condition targeting media users. Like the ‘viral’ and ‘spreadable’ meme, this puritanical obsession with eating can also be considered both a spreadable condition and ideology. According to Hanganu-Bresch, orthorexia sees this diet as a way to overcome an illness or to improve general health, but this also begins to feel righteous and even holy or spiritual. This operates within the context of neoliberalism. Brice and Thorpe talk about women’s activewear worn in everyday settings, or ‘athleisure’, as a neoliberal uniform that says, ‘I’m taking control of my body and health’. To take this idea a step further, this uniform could be extended out into digital spaces as well in terms of what people post on their profiles and social media. This ideological aspect operates as not only a highly spreadable message, but one that is targeted at the overall health of its followers. It encourages not only the spreading of ideology, in this case, white nationalist ideology, but also the modification of food consumption. If this were then to be used as a vehicle to spread messages that encourage white nationalist ideology, it can be seen to be not only a kind of contagion but a powerful one at that. White nationalist iconography that is clearly associated with white supremacist propaganda has the potential to spread extremism. However, neoliberal principles of discipline and bodywork operate through “messages of empowerment, choice, and self-care” (Lavrence and Lozanski, qtd. in Brice and Thorpe). While racist extremism does not necessarily equate to neoliberal and ethnocentric values, a frame of growth, purity, and positivity create an overlap that allow extremist messaging to spread more easily through these networks. Conclusion The case of Pete Evans’s sharing of the butterfly-caterpillar meme exemplifies a concerning overlap between white nationalist discourse and wellness. Ideologically based diets that emphasise real foods, such as the Paleo diet, have a preoccupation with purity and consumption that appeals to white nationalism. They also share a tolerance for the promotion of conspiracy theory and tendency to create an ‘us’ versus ‘them’ dichotomy. Noting these points can provide insight into a potential targeting of the wellness industry to spread racist ideology. As research into spreadability shows, memes are extremely shareable, even if the user does not grasp the meaning behind the symbolism. This article has also extended the idea of the cyberpathy further, noting a weaponisation of the properties of the meme, for the purposes of radicalisation, and how these are accelerated by celebrity influence. This is more potent within the wellness industry when the message is packaged as a form of growth and positivity, which serve to deflect accusations of racism. Furthermore, when diet is combined with white nationalist ideology, it may operate like a contagion, creating the conditions for racism. Those exposed may not have the intention of sharing or spreading racist ideology, but its amplification contributes to the promotion of a racist agenda nevertheless. As such, further investigation into the far-right infiltration of the wellness industry would be beneficial as it could provide more insight into how wellness groups are targeted. 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