Journal articles on the topic 'Analogue Design Processes'
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1
Stopa, Lusia, and David M. Clark. "SOCIAL PHOBIA: COMMENTS ON THE VIABILITY AND VALIDITY OF AN ANALOGUE RESEARCH STRATEGY AND BRITISH NORMS FOR THE FEAR OF NEGATIVE EVALUATION QUESTIONNAIRE." Behavioural and Cognitive Psychotherapy 29, no. 4 (October 2001): 423–30. http://dx.doi.org/10.1017/s1352465801004039.
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This paper discusses the viability of an analogue research design for studying key processes in social phobia by comparing individuals who score high and low on the Fear of Negative Evaluation Scale (FNE: Watson & Friend, 1969). Research indicates remarkable consistency in the processes that distinguish patients with social phobia from controls and high FNE volunteers from low FNE volunteers. Unfortunately, all existing FNE norms are based on North American populations. The present paper presents British student norms and suggests possible cut-off points for defining groups for analogue research. Advantages of the analogue strategy include rapid piloting of new paradigms and the use of more complex experimental designs that require substantial sample sizes. Limitations of analogue research are also highlighted.
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Matthews, Linda, and Samantha Donnelly. "Analogue x digital: Parallel techniques for design learning." Drawing: Research, Theory, Practice 4, no. 2 (November 1, 2019): 225–44. http://dx.doi.org/10.1386/drtp_00004_1.
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Abstract With urban space under the ubiquitous scrutiny of digital visioning technologies, the city is now imaged by means of a pixel grid containing ephemeral, qualitative data presented as colour, brightness and shape. Unlike traditional analogue pictorial representational modes, the digital image is a highly transformable mechanism with an unstable distribution of data across its pixel array. As a consequence, representation in the form of spatial abstraction demands not only a new approach to the learning and implementation of traditional disciplinary drawing practice, but a rethinking of the alignment and cooperative nature of analogue and digital drawing models when applied to effective design development. In a pedagogical context, the transition of spatial representation between analogue and digital modes has profound implications for how the student connects seminal drawing and design processes to both the sensorial realm and the physical experience of lived space. This paper therefore explores the enhancement of tertiary learning in digital and abstract literacy through new drawing techniques. Underpinned by a new relationship between representation and envisioned physical space, the techniques are applied within learning environments in parallel with existing analogue pictorial procedures. By building curriculum for foundational students that provides a framework of linked spatial experiences aligned across analogue and digital domains and coupled with tasks focused on the development of conceptual thinking, it proposes increased student success in future studios and professional practice.
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Didmanidze, Otari, Nikolay Pulyaev, Sergey Devyanin, and Dzhabir Asadov. "Digital analogue of an agricultural tractor." MATEC Web of Conferences 341 (2021): 00058. http://dx.doi.org/10.1051/matecconf/202134100058.
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Today the trend in the digitalisation of all economic spheres is particularly noticeable. Agriculture is no exception here. According to forecasts, the agribusiness transition to Industry-4.0 will increase the yield by 10 %. One of the digital design and modeling technologies is the use of digital analogues of objects or processes. This technology can be applied to an agricultural tractor or other power device. Using this approach will allow you to plan the annual load of machines, taking into account their maintenance condition, efficiency of use, etc. Also such a system will allow to choose the optimal operating modes of agricultural machinery, which in turn will increase its capacity, yield and reduce losses.
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Ivanova, Tatyana N., Aleksandr I. Korshunov, Jozef Peterka, Ivan A. Ratnikov, and Peter Pokorny. "The Possibility of Modeling Parts in Production Technology." Multidisciplinary Aspects of Production Engineering 3, no. 1 (September 1, 2020): 359–73. http://dx.doi.org/10.2478/mape-2020-0031.
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AbstractThe object of the research is a part “Flange half of differential case”, which has complex shape of a housing. The subjects of the research are the processes of selection of analogue material, workpiece production method, and justification of the structural and technological parameters of a part, taking into account 3D-modeling of the structure, deformations, displacements, stresses, and safety factor. The selection of analogue material is connected with suspension of production of open-hearth steel grade Mst.6 GOST 380-50. The objectives of the work include juxtaposition of computer models of deformations, displacements, stresses, safety factors of the part made of different analogue materials; comparison of models according workpiece production methods with consideration of material utilization ratio, structural and technological features of resulting workpieces. For modelling we have chosen the several types of materials. Research on modelling processes was fulfilled by means of software of Kompasv17, Solid Works, Solid works simulation. Volumetric models of parts and workpieces for all studied materials have been created taking into account the deformations, displacements, stresses, and safety factor. There results of modelling of “Flange half of differential case” allowed us to make recommendations for production conditions. These recommendations include the use of steel 45 GOST 1050-2013 as analogue material, hot forging of a workpiece on a horizontal forging machine, creating of design and technological documentation for the manufacture of the part.
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Davis, Mark I., and David M. Clark. "PREDICTORS OF ANALOGUE POST-TRAUMATIC INTRUSIVE COGNITIONS." Behavioural and Cognitive Psychotherapy 26, no. 4 (November 1998): 303–14. http://dx.doi.org/10.1017/s1352465898264022.
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Previous research on vulnerability to Post-Traumatic Stress Disorder (PTSD) has been restricted by the absence of prospective studies that measure individual differences prior to traumatization. This study investigated the predictors of analogue post-traumatic intrusive cognitions using a fully prospective design. Non-patient participants completed a range of predictor measures before being exposed to a film about a traumatic fire. Film-induced changes in negative mood were also assessed. Subsequent intrusions were measured both within the experimental session and for a further seven days. The hypothesized predictors were: neuroticism, trait anxiety, extraversion, depression, a general tendency to suppress unpleasant thoughts, beliefs about being “at risk” from fire, mental imagery, self-rated proneness to intrusions and negative mood changes. The results showed that intrusions were predicted by film-induced increases in negative mood, thought suppression tendencies, beliefs about vulnerability to fire and self-rated proneness to intrusive cognitions. The findings are discussed in relation to the literature on thought suppression and cognitive processes in PTSD.
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Wang, Yujia, Chengwei Sun, Fengyuan Gan, Hongyun Li, Qihuang Gong, and Jianjun Chen. "Sharp phase variations from the plasmon mode causing the Rabi-analogue splitting." Nanophotonics 6, no. 5 (June 24, 2017): 1101–7. http://dx.doi.org/10.1515/nanoph-2016-0163.
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AbstractThe Rabi-analogue splitting in nanostructures resulting from the strong coupling of different resonant modes is of importance for lasing, sensing, switching, modulating, and quantum information processes. To give a clearer physical picture, the phase analysis instead of the strong coupling is provided to explain the Rabi-analogue splitting in the Fabry-Pérot (FP) cavity, of which one end mirror is a metallic nanohole array and the other is a thin metal film. The phase analysis is based on an analytic model of the FP cavity, in which the reflectance and the reflection phase of the end mirrors are dependent on the wavelength. It is found that the Rabi-analogue splitting originates from the sharp phase variation brought by the plasmon mode in the FP cavity. In the experiment, the Rabi-analogue splitting is realized in the plasmonic-photonic coupling system, and this splitting can be continually tuned by changing the length of the FP cavity. These experimental results agree well with the analytic and simulation data, strongly verifying the phase analysis based on the analytic model. The phase analysis presents a clear picture to understand the working mechanism of the Rabi-analogue splitting; thus, it may facilitate the design of the plasmonic-photonic and plasmonic-plasmonic coupling systems.
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Sartori, Julian, Ujjwal Pal, and Amaresh Chakrabarti. "A methodology for supporting “transfer” in biomimetic design." Artificial Intelligence for Engineering Design, Analysis and Manufacturing 24, no. 4 (October 25, 2010): 483–506. http://dx.doi.org/10.1017/s0890060410000351.
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AbstractBiomimetics involves transfer from one or more biological examples to a technical system. This study addresses four questions. What are the essential steps in a biomimetic process? What is transferred? How can the transferred knowledge be structured in a way useful for biologists and engineers? Which guidelines can be given to support transfer in biomimetic design processes? In order to identify the essential steps involved in carrying out biomimetics, several procedures found in the literature were summarized, and four essential steps that are common across these procedures were identified. For identification of mechanisms for transfer, 20 biomimetic examples were collected and modeled according to a model of causality called the SAPPhIRE model. These examples were then analyzed for identifying the underlying similarity between each biological and corresponding analogue technical system. Based on the SAPPhIRE model, four levels of abstraction at which transfer takes place were identified. Taking into account similarity, the biomimetic examples were assigned to the appropriate levels of abstraction of transfer. Based on the essential steps and the levels of transfer, guidelines for supporting transfer in biomimetic design were proposed and evaluated using design experiments. The 20 biological and analogue technical systems that were analyzed were similar in the physical effects used and at the most abstract levels of description of their functionality, but they were the least similar at the lowest levels of abstraction: the parts involved. Transfer most often was carried out at the physical effect level of abstraction. Compared to a generic set of guidelines based on the literature, the proposed guidelines improved design performance by about 60%. Further, the SAPPhIRE model turned out to be a useful representation for modeling complex biological systems and their functionality. Databases of biological systems, which are structured using the SAPPhIRE model, have the potential to aid biomimetic concept generation.
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Mirkovic, Dejan, and Predrag Petkovic. "Design automation of ΔΣ switched capacitor modulators using spice and MATLAB." Serbian Journal of Electrical Engineering 11, no. 1 (2014): 47–59. http://dx.doi.org/10.2298/sjee131017005m.
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Concerning the fact that the design of contemporary integrated circuits (IC) is practically impossible without using sophisticated Electronic Design Automation (EDA) software, this paper gives some interesting thoughts and considerations about that issue. As technology processes advances on year basis consequently EDA industry is forced to follow this trend as well. This, on the other hand, requires IC designer to frequently and efficiently accommodate to new working environments. Authors of this paper suggest a method for high level circuit analysis that is based on using common (open source or low cost) circuit simulators but precise and fast enough to meet requirements imposed by demanding mixed-signal blocks. The paper demonstrates the proposed EDA procedure on an example of second order ?? modulator design. It illustrates considerable simulation time saving which is more than welcome in a world of analogue and mixed-signal design.
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Aminah, Siti, Asep Deni Mulyadi, and Yuliadi Erdani. "The Wireless Acquisition Data System Simulator Design on Automatic Weather Monitoring Station." MOTIVECTION : Journal of Mechanical, Electrical and Industrial Engineering 1, no. 3 (September 1, 2019): 51–62. http://dx.doi.org/10.46574/motivection.v1i3.33.
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The Wireless Acquisition Data System Simulator Design on Automatic Weather Monitoring Station is means of collecting, monitoring, and controlling some long distance subsystems. Automatic weather monitoring station is device for receiving data by a censor in use to gauge some weather parameters. In this Research we develop an automatic weather monitoring station design simulator by creating a subsystem in the form of prototype, using Digital Pin and Analog Pin from the microcontroller. Sensor characteristics are considered to measure several weather parameters. The principles of a system function are it will have to collect data from some subsystems to accommodate in a database, able to control and deliver instructions to the subsystem. The communication system makes the use of radio frequency by means of Frequency Shift Keying (FSK) method through Handy Talky (HT), picked out because advantages of lower power consumptions and long range of transmission. Additional advantages are, although catastrophes, data communication using HT allows to keep fast transmission. The transmission of data using HT media require a signal converter by which HT is operated by analogue signal (sound), while censor and microcontroller by digital signal and, therefore, Modulation and Demodulation techniques are necessary. The Modulation functions to convert digital signal into analogue, and just the opposite to the Demodulation, the Modulation and Demodulation processes is using IC TCM3105. The results of the trial suggest that system design has proper functions, the communication process in this system is two-ways communication, the process was fast working in either transmitter mode or receiver mode.
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Giannouli, Vassiliki, Nikolaos Lougiakis, Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, David A. Horne, Sangkil Nam, Katerina Gioti, and Roxane Tenta. "Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity." Medicinal Chemistry 16, no. 2 (February 20, 2020): 176–91. http://dx.doi.org/10.2174/1573406415666190222130225.
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Background: Purine isosteres are often endowed with interesting pharmacological properties, due to their involvement in cellular processes replacing the natural purines. Among these compounds, pyrazolopyridines are under active investigation for potential anticancer properties. Objective: Based on previously discovered substituted pyrazolopyridines with promising antiproliferative activity, we designed and synthesized new, suitably substituted analogues aiming to investigate their potential activity and contribute to SAR studies of this class of bioactive compounds. Methods: The new compounds were synthesized using suitably substituted 2-amino-4-picolines, which upon ring-closure provided substituted pyrazolo[3,4-c] pyridine-5-carbonitriles that served as key intermediates for the preparation of the target 3,5,7 trisubstituted derivatives. The antiproliferative activity of 31 new target derivatives was evaluated against three cancer cell lines (MIA PaCa-2, PC-3 and SCOV3), whereas cell-cycle perturbations of exponentially growing PC-3 cells, using three selected derivatives were also performed. Results: Eight compounds displayed IC50 values in the low μM range, allowing the extraction of interesting SAR’s. Two of the most potent compounds against all cell lines share a common pattern, by accumulating cells at the G0/G1 phase. From this project, a new carboxamidine-substituted hit has emerged. Conclusion: Among the new compounds, those possessing the 3-phenylpyrazolo[3,4-c]pyridine scaffold, proved to be worth investigating and the majority of them showed strong cytotoxic activity against all cell lines, with IC50 values ranging from 0.87-4.3 µM. A carboxamidine analogue that resulted from the synthetic procedure, proved to be highly active against the cancer cells and could be considered as a useful lead for further optimization.
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Stokes, M. Dale, Grant Deane, Douglas B. Collins, Christopher Cappa, Timothy Bertram, Abigail Dommer, Steven Schill, Sara Forestieri, and Mathew Survilo. "A miniature Marine Aerosol Reference Tank (miniMART) as a compact breaking wave analogue." Atmospheric Measurement Techniques 9, no. 9 (September 1, 2016): 4257–67. http://dx.doi.org/10.5194/amt-9-4257-2016.
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Abstract. In order to understand the processes governing the production of marine aerosols, repeatable, controlled methods for their generation are required. A new system, the miniature Marine Aerosol Reference Tank (miniMART), has been designed after the success of the original MART system, to approximate a small oceanic spilling breaker by producing an evolving bubble plume and surface foam patch. The smaller tank utilizes an intermittently plunging jet of water produced by a rotating water wheel, into an approximately 6 L reservoir to simulate bubble plume and foam formation and generate aerosols. This system produces bubble plumes characteristic of small whitecaps without the large external pump inherent in the original MART design. Without the pump it is possible to easily culture delicate planktonic and microbial communities in the bulk water during experiments while continuously producing aerosols for study. However, due to the reduced volume and smaller plunging jet, the absolute numbers of particles generated are approximately an order of magnitude less than in the original MART design.
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Hautopp, Heidi, and Mie Buhl. "Drawing as an Academic Dialogue Tool for Developing Digital Learning Designs in Higher Education." Electronic Journal of e-Learning 19, no. 5 (November 9, 2021): pp321–335. http://dx.doi.org/10.34190/ejel.19.5.2466.
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This paper reports on how drawing as an academic dialogue tool was explored as a crucial actor for driving design processes among humanistic master’s students targeting their digital learning designs for online and blended learning contexts. The paper builds on a previous study that investigated students’ use of self-produced visualisations during the digital design process. Although the study did not deal with visualisation and students were not trained to draw, the participants made extensive but unacknowledged use of visualisations. In the present study, a new group of students from the same master’s programme were taught how to draw as a central component of the design process in order to investigate how this might expand their use of visual facilitation and drawing techniques to drive collaborative processes, design decisions and theoretical reflections. As design practices enter new interdisciplinary domains, in this case digital learning design, the aim was to explore how humanistic students can act as digital designers by adapting different design approaches and visual methods in particular. Likewise, the study offers an investigation of how students perceive these ways of working in an academic context. The empirical data, including teaching observations, students’ visual productions and interviews with 27 students from nine groups after completing the course, were drawn primarily from an explorative case study in which master’s students developed digital learning designs to solve a problem framed by an external stakeholder. Students’ ways of producing visualisations in the different phases of their design process were analysed in terms of four design genres (explorative, investigative, explanatory and persuasive). The sociomaterial analysis traced how drawings and drawing activities unfolded during collaborative group processes which supported the development of digital learning designs. The findings confirmed the potential of drawing as a means for developing ideas, collaborating in different design phases and presenting and discussing design ideas with peers, target groups and external stakeholders. Furthermore, the findings revealed that drawing activities became a significant pedagogical consideration in the students’ digital learning design and data collection process, where students balanced the interplay between initial analogue drawings and digital prototyping, testing their design concepts with target groups. The findings also showed that students perceived drawing and visual facilitation as practical tools but lacked an academic terminology for articulating these processes. The study suggests a need for substantial change to fully acknowledge the potential of drawing as an academic dialogue tool on the level with academic reading and writing when developing digital artefacts.
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Maldonado, Miguel Paredes. "Knowledge by other means: machinic duration and anexactitude in data-driven urban drawing." Architectural Research Quarterly 24, no. 2 (June 2020): 141–54. http://dx.doi.org/10.1017/s1359135520000160.
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Half a decade past the consolidation of the first ‘digital turn’ in architecture, contemporary designers seem to have decidedly embraced the unprecedented power of machinic thinking, subsequently adopting its embedded logical processes. We may, however, pose a critical question in the context of this ‘second computational turn’ : Are there any non-computable elements of thought in the development of spatialised digital intelligence? As a partial response, this paper unpacks a series of productive relationships intersecting urban drawing and the passing of time in the context of a data-driven design environment. This enquiry looks into the processes carried out by a custom-built robotic drawing machine, tracing dynamic vector data streams collated from fieldwork developed via GPS tracking of individual urban displacements in Cagliari, Sardinia during April 2017. Its machinic drawing protocol re-enacts this continuous, heterogeneous, collectively constructed urban landscape as it slowly remaps its territorial occupation into the target surface of the paper.The hybrid digital-analogue apparatus draws from a long historical lineage of vector-based machinic systems designed for architectural drafting. Situating themselves between the human hand and the surface of the paper, those machines acted as carriers of embodied spatial knowledge that could be selectively actualised into specific design processes and materialisations. Deploying a range of intertwined digital and analogue media, this machinic environment is used to articulate a data-based urban drawing research practice and a subsequent ‘anexact’ drawing research methodology that further elaborates on the durational and multiplicitous aspects of the data-based drawings. This body of work is also reflected on as a visual research methodology, which taps into Bernard Cache's interest in architectural computation as a way to pursue philosophical knowledge ‘by other means’ and into Gilbert Simondon's notion of the ‘technical ensemble’ – emphasising the productive forms of indetermination emerging from its internal informational transfers.
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Klein, Tobias. "Augmented Fauna and Glass Mutations: A Dialogue Between Material and Technique in Glassblowing and 3D Printing." Leonardo 51, no. 4 (August 2018): 336–42. http://dx.doi.org/10.1162/leon_a_01640.
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3D printing allows unprecedented freedom in the design and manufacturing of even the most geometric complex forms—seemingly through a simple click of a button. In comparison, the making of glass is an analogue craftsmanship, coordinating an intricate interplay of individual tools and personal skills, giving shape to a material during the short time of its temperature-based plasticity. The two artworks discussed in this article, Augmented Fauna and Glass Mutations, were created during the artist’s residence at the Pilchuck Glass School and articulate a synthesis between digital workflows and traditional craft processes to establish a digital craftsmanship.
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Hasmar, Wanti, and Indah Permata Sari. "EFEKTIFITAS CHIN TUCK EXERCISE TERHADAP PENINGKATAN AKTIFITAS FUNGSIONAL CERVICAL PADA PEMBATIK." Quality : Jurnal Kesehatan 16, no. 2 (November 29, 2022): 96–101. http://dx.doi.org/10.36082/qjk.v16i2.829.
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Nyeri leher merupakan masalah yang umum ditemukan dua dari tiga orang akan mengalaminya selama hidup, 10% dari semua orang akan mengalami nyeri leher dalam satu bulan. Cedera/proses penyakit pada struktur leher akan menghasilkan spasme otot dan hilangnya fungsi gerak. Chin tuck exercise merupakan salah satu bentuk latihan penguatan yang digunakan untuk otot deep flexor cervical yang terdiri dari otot longus capitis, longus coli. Latihan strengthening berguna untuk meningkatkan fungsi dan kenerja otot. Tujuan penelitian ini adalah untuk mengetahui efektivitas pemberian chin tuck exercise terhadap nyeri dan peningkatan aktifitas fungsional cervical pada pembatik di seberang Kota Jambi. Jenis penelitian yang digunakan adalah eksperimental dengan rancangan pre test dan post test group design. Alat ukur yang digunakan adalah VAS (Visual Analogue Scale) dan Neck Disability Index Qustionnare (NDI). Hasil penelitian terapi Chin Tuck Exercise mempunyai nilai p=0,038 (p<0,05) artinya ada pengaruh yang bermakna terapi Chin Tuck Exercise terhadap peningkatan aktifitas fungsional pada pembatik. Kesimpulan: chin tuck exercise efektif terhadap peningkatan peningkatan aktifitas fungsional pada pembatik.
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Johansson, Michael. "Conversation China." International Journal of Art, Culture and Design Technologies 4, no. 2 (July 2014): 17–31. http://dx.doi.org/10.4018/ijacdt.2014070102.
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This article will present and discuss the design thinking, methods, processes and some examples of work that demonstrates how, together with different co-creators, one sets up a work practice using digital 3d objects and images. That in different ways and formats helps us to explore how a database, a set of rules can be used in a dialogue with artistic work practice and how such a process can be used to create images and animation in a variety of design and art projects. The main example is a project called Conversation China that still is in its making, here one works with rather complex processes, involving several digital analogue techniques as the basis for creating the images for a 150 pieces porcelain dinner set. The author's interest in this work is how the intention of the artist or designer is transferred and later embedded in the procedural or algorithmic process and how this intent is organized and set up to secure an desired outcome, mixing the possibilities of the digital media object with manual editing and artistic craftsmanship. What this article tries to put forward is how we designed and set up environments for working with non linear and procedural media, their different expressions and forms by using explorable prototypes and design thinking?
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Ingrassia, Marco. "Participatory design games for citizenship education A public space approach with children." Sociology and Social Work Review 6, no. 2 (December 29, 2022): 128–37. http://dx.doi.org/10.58179/sswr6211.
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Citizenship education plays a key role in urban societies, as it supports the construction of inclusive, sustainable and healthy communities, promoting values of responsibility, activism, inclusivity, diversity, collaboration. Civic and Citizenship courses in schools’ curricula worldwide gives positive results, but critical barriers can be noted, including: the difficulty for children to understand complex theoretical and abstract notions. Some scholars suggest that education is more effective when democratic processes are experienced by children through decision-making, including through the use of games. Participatory design strategies for the public space, together with placemaking actions, have been promoted since the 1970s to engage adults in decision making processes, with the objective of collecting proposals on urban transformation, strengthening communities, educating to citizenship, with values of inclusivity, diversity, sustainability, activating the citizen agency by encouraging activism. Participatory design strategies can benefit from the use of gamification strategies and serious game approaches to achieve audience development, engagement and conflict resolution. This research appraises the possibility to use participatory design games, focused on the public space, as tools for citizenship education of children (aged 5-12). Three case studies developed in Spain and Italy are presented, based on the use of digital and analogue interfaces. Case studies are assessed and compared on their capacity to stimulate interest in children through time, foster interaction and active collaboration between peers, educate to conflict resolution, Educate to inclusivity and diversity, promote behavioural change towards sustainability, collect Data on desires in relation to the public space. Results suggest that participatory design games focused are successful as educational tools, regardless of the real implementation of the design solutions.
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Stanculescu, Marilena, Mihai Iordache, Dragos Niculae Niculae, Lavinia Iordache, and Victor Bucata. "S Parameter Computation and Their Use for Electromagnetic Energy Wireless Transmission." INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 15, no. 9 (June 22, 2016): 7097–109. http://dx.doi.org/10.24297/ijct.v15i9.654.
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This paper present the correct way of defining S parameters, based on linear electrical circuits, and the practical use of these parameters in obtaining efficient processes for transmitting the information and of the electromagnetic energy wireless transfer from emitter-receiver signal transmission point of view. Here are presented, also, two procedures for calculating these parameters, one based on modified nodal analyses, the second one based on state equations method. S parameters generation algorithm has the same structure for both computation procedures. The computation procedures for S parameters use the most advanced analogue circuit simulation programs, such as: Cadence, Advances Design System, Ansoft Extractor Q3D, Feko, ECAP, SYSEG etc. Finally, there are presented a few illustrative examples that certify the validity of the used computation procedures.
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Sichani, Anna-Maria, and David Hendy. "Connected Histories of the BBC: Opening up the BBC Oral History Archive to the Digital Domain." Journal on Computing and Cultural Heritage 15, no. 1 (February 28, 2022): 1–16. http://dx.doi.org/10.1145/3480954.
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This article describes the computational and data-related challenges of the “Connected Histories of the BBC” project, an interdisciplinary project aiming to bring into the public realm some of the hidden treasures of the BBC's own Oral History Archive through the creation of an openly accessible, fully searchable and interconnected digital catalogue of this archive. This project stands as an interesting case study on the tensions between “computational” and “archival”, by critically designing and employing computational approaches for an historical, complex Oral History collection of scattered analogue records of various forms with an archival pre-history. From data acquisition, modeling, structuring and enhancement, metadata, data analysis procedures, to web design and legal issues, this paper discusses the various computational challenges, processes and decisions made during this project, while showcasing the principles of (re)usability, accessibility, and collaboration throughout its course.
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Dollery, Brian E., and Andrew C. Worthington. "The Evaluation of Public Policy: Normative Economic Theories of Government Failure." Journal of Interdisciplinary Economics 7, no. 1 (January 1996): 27–39. http://dx.doi.org/10.1177/02601079x9600700103.
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Conventional economic analysis of public policy has been traditionally conducted in the conceptual context of the theory of market failure. The resultant analytical framework enabled analysts to assess the economic efficiency of market outcomes, and prescribe appropriate government intervention where necessary. No corresponding theoretical structure existed to facilitate an equivalent investigation into the economic efficiency of nonmarket outcomes. However, quite distinct from public choice theory, a normative theory of government failure has emerged to form a conceptual analogue to the market failure paradigm. At present this embryonic theory of government failure has three strands: Wolf’s theory of nonmarket failure, Le Grand’s theory of government failure, and Vining and Weimer’s theory of government production failure. The present paper evaluates the extent to which this seminal literature can assist in the design of rational public policy processes.
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Theophanidis, Philippe, and Ghislain Thibault. "Media hysteresis." Alphaville: Journal of Film and Screen Media, no. 12 (February 10, 2017): 8–23. http://dx.doi.org/10.33178/alpha.12.01.
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For media scholars, locating the old in the new helps to debunk the inflation around the “newness” of contemporary media. Several approaches have been put to work in the exploration of these multiple temporalities within media: remediation, media revival, residual media, media archeology. In this article, we explore another temporal concept—hysteresis—as a way to think through the folding of time within and across media. The first part of the article presents a theoretical overview of the concept of hysteresis, from the field of experimental sciences in the late nineteenth century to Marx, Bourdieu, Baudrillard and others in the social sciences. In the second part, we introduce the concept of “media hysteresis” and illustrate it with two examples: the design of the keypad by Bell System’s push-button phones and the QWERTY keyboard. In the third and final part, we weave the concept of media hysteresis through a discussion of some of the major changes in cinema. More specifically, we examine how the aesthetic of the analogue persists in digital media and how media hysteresis can be useful to apprehend the celluloid revival. Our main argument throughout the article is the need for a theory of asynchronous simultaneity to analyse persistence and continuity across technological changes.
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BINNS, M. D., F. J. CLOUGH, and S. C. J. GARTH. "AN ARCHITECTURE FOR FULLY INTEGRATED LARGE SCALE NEURAL NETWORKS." International Journal of Neural Systems 04, no. 04 (December 1993): 327–32. http://dx.doi.org/10.1142/s0129065793000262.
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To apply neural networks to many engineering applications, large networks will be required. Such networks are difficult to build using standard crystalline silicon technology due to limitations in both the fabrication and packaging processes. An architecture is proposed where amorphous silicon photoresistors are used to store the synaptic weights. A single plate of amorphous silicon is able to contain up to 100 million photoresistors, exploiting readily available fabrication technology. Using an external light source, each photoresistor can be individually adjusted allowing them to be configured as programmable fixed-value resistors. The processing compatibility of polysilicon and amorphous silicon allows the same glass substrate to be used for large-area integration of the photosensors, the analogue neural network and the neurons. The integration of the photosensors and the rest of the network may be used to alleviate the interface problem at the inputs resulting in a design with a very simple architecture that is both elegant and simple to fabricate. This paper describes such a design in which amorphous silicon technology is applied to neural network hardware.
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Nannipieri, Pietro, Stefano Di Matteo, Luca Baldanzi, Luca Crocetti, Jacopo Belli, Luca Fanucci, and Sergio Saponara. "True Random Number Generator Based on Fibonacci-Galois Ring Oscillators for FPGA." Applied Sciences 11, no. 8 (April 7, 2021): 3330. http://dx.doi.org/10.3390/app11083330.
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Random numbers are widely employed in cryptography and security applications. If the generation process is weak, the whole chain of security can be compromised: these weaknesses could be exploited by an attacker to retrieve the information, breaking even the most robust implementation of a cipher. Due to their intrinsic close relationship with analogue parameters of the circuit, True Random Number Generators are usually tailored on specific silicon technology and are not easily scalable on programmable hardware, without affecting their entropy. On the other hand, programmable hardware and programmable System on Chip are gaining large adoption rate, also in security critical application, where high quality random number generation is mandatory. The work presented herein describes the design and the validation of a digital True Random Number Generator for cryptographically secure applications on Field Programmable Gate Array. After a preliminary study of literature and standards specifying requirements for random number generation, the design flow is illustrated, from specifications definition to the synthesis phase. Several solutions have been studied to assess their performances on a Field Programmable Gate Array device, with the aim to select the highest performance architecture. The proposed designs have been tested and validated, employing official test suites released by NIST standardization body, assessing the independence from the place and route and the randomness degree of the generated output. An architecture derived from the Fibonacci-Galois Ring Oscillator has been selected and synthesized on Intel Stratix IV, supporting throughput up to 400 Mbps. The achieved entropy in the best configuration is greater than 0.995.
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Vychaktami, Kharissa Kemala, Rahmi Amtha, Indrayadi Gunardi, and Rosnah Binti Zain. "The effect of herbal medicine in reducing the severity of oral lichen planus: A systematic review and meta-analysis." Dental Journal (Majalah Kedokteran Gigi) 55, no. 3 (September 1, 2022): 165–73. http://dx.doi.org/10.20473/j.djmkg.v55.i3.p165-173.
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Background: Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disease of unknown aetiology. The reported use of herbal medicines may promote the healing of OLP lesions. Purpose: We aim to determine the effectiveness of herbal medicine to reduce the clinical and pain severity of OLP. Methods: PubMed, Cochrane Library and Wiley Online Library were reviewed according to the inclusion criteria. Risk of bias was performed for the randomised control trial (RCT) and cohort studies to assess the effectiveness of herbal medicines for OLP treatment. Outcomes were recorded based on pain severity and the quality of life of patients with OLP. The mean difference and effect size of studies were pooled. Reviews: Out of 1,034 papers, six publications were selected and reviewed. The most common types of OLP lesions were erosive and atrophic and were mainly found at the buccal site. OLP was common in the range of 27–74 years, especially in females. The herbal medicines used in the publication were curcumin, lycopene, purslane, aloe vera and quercetin. Improvement in quality of life or OLP severity was recorded in the intervention group treated with purslane, curcumin and lycopene (P<0.05) but not in the control group. The total effect of herbal medicine in reducing pain severity (measured with the Visual Analogue Scale [VAS]) in OLP patients was not significant (mean difference 0.13; 95% CI -0.202 to 0.463; p=0.442). Conclusions: Herbal medicine cannot be used as a single regime to reduce pain severity. Further research is recommended to evaluate cohort design studies to observe the prolonged effect of herbal medicine in OLP lesions. PROSPERO registration number: CRD42021262282 (2021)
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Velbitsky, Igor. "Programming without Programming Languages (New Graphic Poliglot Сoncept)." Application and Theory of Computer Technology 2, no. 2 (February 28, 2017): 26. http://dx.doi.org/10.22496/atct20170124135.
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For the first time since 1947 it is proposed to use a simpler and mathematically more rigorous concept of programming with the graphs loaded only through horizontal arcs with characters, functions and expressions of elementary mathematics. Such graph is a polyglot, it has ISO 8631/1989 standard, and is the only one that can be used effectively throughout the life cycle of program design and use. Conventional programming languages are not needed. The new concept has 100+ times better characteristics with regard to visualization, simplicity, and compactness, as well as the speed of entering into the computer. Processes of error-free design of algorithms, programs, and data structures, evidence of their correctness, self-documenting and documenting of motivation of decisions made are significantly simplified, improved and accelerated. The resulting programs are more effective on the memory footprint and execution time. The larger and the more complex is the program project, the greater is the effect of applying the new concept. The new concept is so simple that it makes it possible to program for ANYONE, not just for programmers. We do not know analogue of the new concept. This article describes the history of developing and proving the new concept, its description, advantages, implemented graphical programming environment, and perspectives for its application.
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Saretta, Erika, Pierluigi Bonomo, Willy Maeder, Van Khai Nguyen, and Francesco Frontini. "Digitalization as a driver for supporting PV deployment and cost reduction." EPJ Photovoltaics 13 (2022): 1. http://dx.doi.org/10.1051/epjpv/2021013.
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Digitalization is providing advantages to all sectors around the world and it can be of relevance also for the photovoltaic (PV) sector. As an example, the current value chain of the European PV sector is often characterized by analogue and fragmented processes that should be overcame to support greater PV deployment. The adoption of a more open and collaborative digital-based approach characterized by data-sharing among different stakeholders and more integrated information thread from the design till O&M can provide direct benefits in optimizing the PV process, increasing performances, and reducing of costs. Therefore, a novel PV Information Management (PIM) approach has been drawn within the European H2020 project “SuperPV”. In accordance with PIM objectives, a workflow for seamlessly transferring data along main PV work-stages has been developed, as well as new digital features to specifically address collaborative approach in the PV sector such as: (i) advanced functionalities introduced in the existing BIMSolar® software for improving the simultaneous design, performance simulation and cost assessment of medium and large PV systems, (ii) a proof-of-concept for aggregating all relevant information into a Digital Twin platform aimed at setting the ground for post-construction management and lifecycle assessment of the whole PV system.
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Xie, Ziyi, Junsong Peng, Mariia Sorokina, and Heping Zeng. "Design of Mode-Locked Fibre Laser with Non-Linear Power and Spectrum Width Transfer Functions with a Power Threshold." Applied Sciences 12, no. 20 (October 13, 2022): 10318. http://dx.doi.org/10.3390/app122010318.
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There is a growing demand for higher computational speed and energy efficiency of machine learning approaches and, in particular, neural networks. Optical implementation of neural networks can address this challenge. Compared to other neuromorphic platforms, fibre-based technologies can unlock a wide bandwidth window and offer flexibility in dimensionality and complexity. Moreover, fibre represents a well-studied, low-cost and low-loss material, widely used for signal processing and transmission. At the same time, mode-locked fibre lasers offer flexibility and control, while the mode-locking effect can be crucial for unlocking ultra-short timescales and providing ultra-fast processing. Here, we propose a mode-locked fibre laser with a non-linear power threshold in both power and spectrum. The advantage of the proposed system is a spectrum width two-branch function dependent on the input signal power. The effect is caused by a transition between two operating regimes and is governed by the input signal power. The proposed design enables receiving a non-linear transfer function in amplitude with a power threshold as an optical analogue of biological neurons with the additional advantage of a non-linear two-branch transfer function in spectrum width. The latter property is similar to the frequency-varied response dependent on stimulus properties in biological neurons. Thus, our work opens new avenues in research into novel types of artificial neurons with a frequency spectrum width variable response and, consequently, spiking neural networks and neural-rate-based coding with potential applications in optical communications and networks with flexible bandwidth, such as 5G and emerging 6G.
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Tambo, Torben, and Jacob Filtenborg. "Digital services governance: IT4IT™ for management of technology." Journal of Manufacturing Technology Management 30, no. 8 (December 9, 2019): 1230–49. http://dx.doi.org/10.1108/jmtm-01-2018-0028.
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Purpose The purpose of this paper is to present, analyse and demonstrate the impact and potentials of a pragmatically derived information technology (IT) governance framework, IT4IT™, for the discipline of management of technology (MoT) especially within the IT industry. Design/methodology/approach This paper is based on an extensive literature study working with the limitations of the relatively recent publication of IT4IT™ and the normative character of IT4IT™. A mixed-method case study is presented based on an IT service provider organisation. Both a qualitative method and a systems and design oriented method are being used. Findings IT4IT™ can provide value and a clearer understanding of the service delivery framework if the technological core of the focal organisation is adapted to a value stream thinking. This suggests a more operational character of all IT processes and analogue to general MoT frameworks and corporate governance models. Research limitations/implications Given the recent publication of the IT4IT™ framework, this study is primarily ex ante and suggests further full-scale ex post research in the future. Practical implications Validation and successful implementation of the IT4IT™ framework will give companies better opportunities for safe and controlled value creation using IT. Control connects with risk reduction and less risk can encourage innovation and “tame” development complexity. Using value streams will align IT better with manufacturing and services. Originality/value Companies are striving to seek governance and risk minimisation in IT development and operations. This paper is discussing the applicability of the IT4IT™ framework for finding a better understanding of the value creation and value proposition delivered by introducing controlled processes minimising risk.
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Gliga, Laura-Elena, Bogdan-Cezar Iacob, Sanda-Nastasia Moldovean, David A. Spivak, Andreea Elena Bodoki, Ede Bodoki, and Radu Oprean. "Analytical Perspectives in the Study of Polyvalent Interactions of Free and Surface-Bound Oligonucleotides and Their Implications in Affinity Biosensing." International Journal of Molecular Sciences 24, no. 1 (December 22, 2022): 175. http://dx.doi.org/10.3390/ijms24010175.
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The high affinity and/or selectivity of oligonucleotide-mediated binding offers a myriad of therapeutical and analytical applications, whose rational design implies an accurate knowledge of the involved molecular mechanisms, concurring equilibrium processes and key affinity parameters. Oligonucleotide-functionalized gold surfaces or nanostructures are regularly employed analytical platforms for the development of label-free optical or electrochemical biosensors, and recently, novel detection platform designs have been increasingly considering the synergistic effect of polyvalent binding, involving the simultaneous interaction of two or several oligonucleotide strands. Considering the general lack of studies involving ternary single-stranded DNA (ssDNA) interactions, a complementary analytical workflow involving capillary gel electrophoretic (CGE) mobility shift assay, microcalorimetry and computational modeling has been deployed for the characterization of a series of free and surface-bound binary and ternary oligonucleotide interactions. As a proof of concept, the DNA analogue of MicroRNA 21 (miR21), a well-known oncogenic short MicroRNA (miRNA) sequence, has been chosen as a target molecule, simulating limiting-case scenarios involved in dual molecular recognition models exploited in affinity (bio)sensing. Novel data for the characterization of oligonucleotide interacting modules is revealed, offering a fast and complete mapping of the specific or non-specific, often competing, binary and ternary order interactions in dynamic equilibria, occurring between various free and metal surface-bound oligonucleotides.
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Newman-Taylor, Katherine, Monica Sood, Angela C. Rowe, and Katherine B. Carnelley. "The Impact of Repeated Attachment Priming on Paranoia, Mood and Help-Seeking Intentions in an Analogue Sample." Brain Sciences 11, no. 10 (September 22, 2021): 1257. http://dx.doi.org/10.3390/brainsci11101257.
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Attachment security priming effects therapeutic change in people with depression and anxiety. Preliminary studies indicate that visualising secure attachment memories also reduces paranoia in non-clinical and clinical groups, probably due to a decrease in cognitive fusion. Benefits to clinical populations depend on the sustainability of these effects and the impact on help-seeking behaviours. The combination of paranoia and an insecure-avoidant attachment style is likely to be a particular barrier to help seeking. We used a longitudinal experimental design to test the impact of repeated attachment priming on paranoia, mood and help-seeking intentions and whether cognitive fusion mediates these effects. Seventy-nine people with high levels of non-clinical paranoia, aged 18–50 years (M = 20.53, SD = 4.57), were randomly assigned to a secure or insecure-avoidant priming condition. Participants rehearsed the visualisation prime on four consecutive days and were assessed on standardised measures of paranoia, positive and negative affect, help-seeking intentions and cognitive fusion. A series of mixed-model analyses of variance showed that security priming decreases paranoia, negative affect and cognitive fusion and increases positive affect and help seeking, compared to insecure-avoidant priming. Examining the impact of primed attachment (rather than measured attachment style) allows us to draw conclusions about the causal processes involved; mediation analyses showed indirect effects of the primes on paranoia and negative affect through cognitive fusion. With a growing understanding of (1) the impact of security priming on paranoia, affect and help-seeking behaviours, (2) causal mechanisms and (3) sustainability of effects, security priming may be developed into a viable intervention for clinical populations.
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Mishra, Manasi, Vigyasa Singh, Meenakshi B. Tellis, Rakesh S. Joshi, and Shailja Singh. "Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases." Pharmaceuticals 14, no. 1 (December 23, 2020): 7. http://dx.doi.org/10.3390/ph14010007.
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Clan C1A or ‘papain superfamily’ cysteine proteases are key players in many important physiological processes and diseases in most living systems. Novel approaches towards the development of their inhibitors can open new avenues in translational medicine. Here, we report a novel design of a re-engineered chimera inhibitor Mco-cysteine protease inhibitor (CPI) to inhibit the activity of C1A cysteine proteases. This was accomplished by grafting the cystatin first hairpin loop conserved motif (QVVAG) onto loop 1 of the ultrastable cyclic peptide scaffold McoTI-II. The recombinantly expressed Mco-CPI protein was able to bind with micromolar affinity to papain and showed remarkable thermostability owing to the formation of multi-disulphide bonds. Using an in silico approach based on homology modelling, protein–protein docking, the calculation of the free-energy of binding, the mechanism of inhibition of Mco-CPI against representative C1A cysteine proteases (papain and cathepsin L) was validated. Furthermore, molecular dynamics simulation of the Mco-CPI–papain complex validated the interaction as stable. To conclude, in this McoTI-II analogue, the specificity had been successfully redirected towards C1A cysteine proteases while retaining the moderate affinity. The outcomes of this study pave the way for further modifications of the Mco-CPI design for realizing its full potential in therapeutics. This study also demonstrates the relevance of ultrastable peptide-based scaffolds for the development of novel inhibitors via grafting.
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Wąsowicz, Magdalena. "Figuracja cyfrowa a model figura-tło w projektowaniu współczesnej architektury mieszkaniowej." Środowisko Mieszkaniowe, no. 39 (October 31, 2022): 33–41. http://dx.doi.org/10.4467/25438700sm.22.011.16589.
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Niniejszy artykuł przedstawia zagadnienie możliwych kierunków ewolucji konceptów kreacji warunków postrzegania architektury. W artykule postawiono pytanie o kierunki zmian postrzegania środowiska mieszkaniowego przyszłości w kontekście zmniejszającego się udziału architekta w procesie projektowym na rzecz zautomatyzowanych procesów cyfrowych. Studia tego tematu przeprowadzono metodą analityczną jakościową oraz metodą badań bibliograficznych. Do analizy projektów i ich szerokiego kontekstu zastosowany został aparat pojęciowy zapożyczony z psychologii postaci w architekturze. Pozwala on wskazać podobieństwa i różnice w projektowaniu opartym na decyzji projektanta, parametrycznym i generowanym przez sztuczną inteligencję na podstawie figuracji będącej jego rezultatem. Dotychczas w literaturze nie przeprowadzono szczegółowej analizy narzędzi cyfrowych służących wspomaganiu projektowania w kontekście aspektu postrzeżeniowego odbiorcy. Digital figuration versus analogue figure-ground model in contemporary residential architecture design This article presents the issue of possible directions of evolution of the concepts of creation of conditions of perception of architecture. The paper asks the question about the directions of changes in the perception of the residential environment of the future in the context of decreasing participation of the architect in the design process in favor of automated digital processes. The study of this topic was carried out using a qualitative analytical method and a bibliographic research method. A conceptual apparatus borrowed from the psychology of characters in architecture was used to analyze the projects and their broad context. It allows indicating the similarities and differences in design based on the designer’s decision, parametric, and generated by artificial intelligence on the basis of the resulting figuration. So far, no detailed analysis of digital tools for design support has been performed in the literature in the context of the perceptual aspect of the viewer.
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Rani, Nishu, Mayur Agarwal, Pawan Kumar, and Pankaj Kumar. "Speed Control of Single Phase Induction Motor by Using Wireless Technology." International Journal of Advance Research and Innovation 3, no. 2 (2015): 101–5. http://dx.doi.org/10.51976/ijari.321523.
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Single phase induction motors are widely used in home appliances and Industrial control because of their low cost and rugged construction. Many industrial processes require variable speed drives for various applications. Many applications need variable speed operation and one of them is a simple fan load. The RF generator which generates the analog output signal for the corresponding button pressed using PCB. This analogue output is fed to the RF Transmitter and sent through the antenna. At the other end, the RF Receiver picks up the signal and feeds it to the signal decoder, there the decoding takes place and this decoding data is given to the Micro controller 89S51. The software in the Micro controller receives the signal and accordingly drives the TRIAC Circuit, which in turn is connected to load serially which is used to generate the PWM pulses for speed control of the single phase induction motor. The main aim of the this paper is to design an real time electronic control system that can be used to control the speed of motors kept at remote locations using an embedded technology.
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SEREDA, Vladyslav A., Maya V. AMBROZHEVICH, and Aleksey V. KORNEV. "Method of Compact Ground Launching Devices Shape Formation for Unmanned Aerial Vehicles." Problems of Mechatronics Armament Aviation Safety Engineering 13, no. 1 (March 31, 2022): 9–26. http://dx.doi.org/10.5604/01.3001.0015.8101.
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The purpose of this paper is to develop a method for forming the shape of compact ground launching devices (GLDs) unmanned aerial vehicles (UAVs), which includes three stages. Firstly, the choice on the basis of the theory of dimension and similarity of the closest analogue of the design object based on world experience gained in this field. Secondly, the creation of a comprehensive model of the working process of GLD and a universal method for its numerical implementation. Thirdly, the solution to the problem of optimizing the dynamic characteristics of GLD. At the described stages of the formation of the shape of an GLD UAV, a statistical analysis of the technical perfection of known analogues of UAV launch systems, methods of the theory of similarity and dimension in mechanics, methods of numerical simulation of the working process, and also methods of conditional parametric optimization are used. The undoubted importance of the problem of the equivalent development of the components of the UAS, consisting of an aircraft and a launch system (catapult). The traditionally non-priority status of GLD in the general cycle of the complex design program is also known. A systematic solution to this problem lies in the mainstream of creating common approaches, one of which is contained in this article. The proposed method of forming the appearance of compact GLDs UAV can be extended to a wide class of starting systems containing a thermal expansion machine and a mechanical component. In the presented form, the method is not applicable to systems of air, aerodrome and manual launch of UAVs. A method has been developed for the formation of the shape of GLD based on the energy relations of the criterion type between useful functions and the corresponding costs, with subsequent verification numerical studies of the launch processes based on specially created technology of a computational experiment, as well as optimization of the dynamic characteristics of GLD. The method of forming the shape of compact GLD is universally applicable to any type of catapults, regardless of the type of transmission and drive, since many particular forms of organization of the working process are generalized using the criteria of energy perfection, a comprehensive physical and mathematical model and normalization of the starting overload.
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Sharp, H., K. Themelis, M. Amato, A. Barritt, K. Davies, N. Harrison, H. Critchley, S. Garfinkel, and J. Eccles. "The role of interoception in the mechanism of pain and fatigue in fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)." European Psychiatry 64, S1 (April 2021): S139. http://dx.doi.org/10.1192/j.eurpsy.2021.382.
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IntroductionPain, fatigue and anxiety are common features of fibromyalgia and ME/CFS and significantly impact quality of life. Aetiology is poorly defined but dysfunctional inflammatory, autonomic and interoceptive (sensing of internal bodily signals) processes are implicated.ObjectivesTo investigate how altered interoception relates to baseline expression of pain, fatigue and anxiety symptoms in fibromyalgia and ME/CFS and in response to an inflammatory challenge.MethodsSixty-five patients with fibromyalgia and/or ME/CFS diagnosis and 26 matched controls underwent baseline assessment: pressure-pain thresholds and self-report questionnaires assessing pain, fatigue and anxiety severity. Participants received injections of typhoid (inflammatory challenge) or saline (placebo) in a randomised, double-blind, crossover design, before completing heartbeat tracking tasks. Three interoception dimensions were examined: subjective sensibility, objective accuracy and metacognitive awareness. Interoceptive trait prediction error was calculated as discrepancy between accuracy and sensibility.ResultsPatients with fibromyalgia and ME/CFS had significantly higher interoceptive sensibility and trait prediction error, despite no differences in interoceptive accuracy. Interoceptive sensibility and trait prediction error correlated with all self-report pain, fatigue and anxiety measures, and with lower pain thresholds. Anxiety mediated the positive-predictive relationships between pain (Visual Analogue Scale and Widespread Pain Index), fatigue impact and interoceptive sensibility. After inflammatory challenge, metacognitive awareness correlated with baseline self-reported symptom measures and lower pain thresholds.ConclusionsThis is the first study investigating interoceptive dimensions in patients with fibromyalgia and ME/CFS, which were found to be dysregulated and differentially influenced by inflammatory mechanisms. Interoceptive processes may represent a new potential target for diagnostic and therapeutic investigation in these poorly understood conditions.DisclosureNo significant relationships.
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Kuzina, Ju, M. Arnoldov, Yu Orlov, and A. Sorokin. "THERMOPHYSICAL INVESTIGATIONS: FROM THE FIRST TO STAND LARGE-SCALE NUCLEAR ENERGY." PROBLEMS OF ATOMIC SCIENCE AND TECHNOLOGY. SERIES: NUCLEAR AND REACTOR CONSTANTS 2021, no. 2 (June 26, 2021): 236–55. http://dx.doi.org/10.55176/2414-1038-2021-2-236-255.
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The article presents the main research results of thermal physicists of the IPPE from its inception to the present time. Research results in the areas of heat and mass transfer and hydrodynamics of coolants (liquid metals, water), physical chemistry and technology of liquid metal coolants for nuclear power plants for various purposes (nuclear power plants, nuclear submarines, space nuclear power plants), development codes, innovative projects, non-nuclear technologies for the use of liquid metals, heat pipes, analysis and generalization of thermophysical data are considered in the article. As a result of a large complex of experimental and computational studies, the fundamental physicochemical and thermohydraulic regularities of the coolant - impurities - structural materials - protective gas have been studied, scientific foundations have been created for the use of liquid metal coolants in nuclear power. Studies have been carried out to substantiate the technical and economic characteristics of nuclear fuel for operating, under construction and future NPPs of VVER RP, design solutions for passive safety, technical solutions and hydrogen safety devices, heat removal from the reactor through a steam generator and PHRS in case of beyond design basis accidents. As well as design solutions and safety for NPP designs with BN-1200 reactor with sodium coolant, BREST-OD-300 reactor with lead coolant, SVBR-100 reactor with lead-bismuth alloy, MBIR research reactor. The results of these studies made it possible, together with institutes and design organizations, to scientifically substantiate thermal-hydraulic parameters and highly efficient technological processes, develop and practically implement devices and systems that ensure the successful operation of fundamentally new nuclear power plants cooled by water and liquid metals, with original scientific and technical solutions that had no analogue in world practice. R&D works were carried out to substantiate the innovative project VVER with supercritical pressure, the concept of an electro-nuclear subcritical blanket based on the modular principle of constructing an core with liquid-salt melts of fissile materials, studies of thermal hydraulics, mass transfer of high-temperature sodium and the development of a combined coolant purification system to justify the BN-HT reactor with temperature sodium ~900 °C for hydrogen production. The directions of investigations at the present stage are discussed.
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Tard, Cédric, Stacey Borg, Shirley Fairhurst, Christopher Pickett, and Stephen Best. "Electronic Communication between Dithiolato-Bridged Diiron Carbonyl and S-Bridged Redox-Active Centres." Inorganics 7, no. 3 (March 8, 2019): 37. http://dx.doi.org/10.3390/inorganics7030037.
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The catalytic potential of linked redox centres is exemplified by the catalytic site of [FeFe]-hydrogenases, which feature a diiron subsite linked by a cysteinyl S atom to a 4Fe4S cube. The investigation of systems possessing similarly-linked redox sites is important because it provides a context for understanding the biological system and the rational design of abiological catalysts. The structural, electrochemical and spectroscopic properties of Fe2(CO)5(CH3C(CH2S)2CH2SPhNO2, I-bzNO2 and the aniline analogue, I-bzNH2, are described and IR spectroelectrochemical studies have allowed investigation of the reduction products and their reactions with CO and protons. These measurements have allowed identification of the nitrobenzenyl radical anion, quantification of the shifts of the (CO) bands on ligand-based reduction compared with NO2/NH2 exchange and protonation of the pendent ligand. The strength of thioether coordination is related to the electronic effects, where competitive binding studies with CO show that CO/thioether exchange can be initiated by redox processes of the pendent ligand. Stoichiometric multi electron/proton transfer reactions of I-bzNO2 localised on nitrobenzene reductions occur at mild potentials and a metal-centred reduction in the presence of protons does not lead to significant electrocatalytic proton reduction.
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Meier, Chris. "Nucleoside diphosphate and triphosphate prodrugs – An unsolvable task?" Antiviral Chemistry and Chemotherapy 25, no. 3 (November 3, 2017): 69–82. http://dx.doi.org/10.1177/2040206617738656.
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In this review, our recent advances in the development of nucleoside di- and nucleoside triphosphate prodrugs is summarized. Previously, we had developed a successful membrane-permeable pronucleotide system for the intracellular delivery of nucleoside monophosphates as well, the so-called cycloSal-approach. In contrast to that work in which the delivery is initiated by a chemically driven hydrolysis reaction, for the di- and triphosphate delivery, an enzymatic trigger mechanism involving (carboxy)esterases had to be used. The other features of the new pronucleotide approaches are: (i) lipophilic modification was restricted to the terminal phosphate group leaving charges at the internal phosphate moieties and (ii) appropriate lipophilicity is introduced by long aliphatic residues within the bipartite prodrug moiety. The conceptional design of the di- and triphosphate prodrug systems will be described and the chemical synthesis, the hydrolysis properties, a structure–activity relationship and antiviral activity data will be discussed as well. The advantage of these new approaches is that all phosphorylation steps from the nucleoside analogue into the bioactive nucleoside triphosphate form can be bypassed in the case of the triphosphate prodrugs. Moreover, enzymatic processes like the deamination of nucleosides or nucleoside monophosphates which lead to catabolic clearance of the potential antivirally active compound can be avoided by the delivery of the higher phosphorylated nucleotides.
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Chernov, Igor, Аnton Kushtym, Volodymyr Tatarinov, and Dmytro Kutniy. "Manufacturing Features and Characteristics of Uranium Dioxide Pellets for Subcritical Assembly Fuel Rods." 3, no. 3 (September 2, 2022): 59–66. http://dx.doi.org/10.26565/2312-4334-2022-3-08.
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The influence of technological processes and manufacturing of uranium dioxide fuel pellets for fuel elements for experimental fuel assembly (FA-X) which was designed as an alternative fuel for the nuclear research installation (NRI) "Neutron Source Controlled by Electron Accelerator" were investigated. Unlike standard production processes of UO2 pellets, the special feature fabrication process of this nuclear fuel type is production of uranium dioxide powder with enrichment of 4.4 %wt. of 235U achieved by mixing of two batches of powders with different uranium contents: 0.4 %wt. 235U and 19.7%wt. 235U, as well as ensuring the required tolerance of fuel pellets without the use of machining operations. A set of design and process documentation were developed in the R&D Center at NSC KIPT. Experimental stack of fuel pellets, fuel elements and a pilot fuel assembly FA-X were fabricated and designed to be compatible and interchangeable with VVR-M2 fuel assembly adopted as a standard assembly for the first fuel loading at the "Neutron Source Driven by an Electron Accelerator" FA. As opposition to the variant of VVR-M2 fuel assembly which consisted of three fuel rods of tubular shape with dispersion composition UO2‑Al, FA-X accommodates six fuel rods of pin-type with UO2 pellet which located in the zirconium cladding (E110) as the closest analogue of fuel rods of VVER-1000 power reactor. Inside cladding locate a 500 mm high fuel stack which is secured against displacement by a spacer. In the basic variant of FA-X the fuel pellets are made of UO2 with 235U enrichment near 4.4 %wt.
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Gahi, Narcisse Zegbé, Kouassi Dongo, Aimé Koudou, and Mathieu Badolo. "Innovative approach to build a “no regret” framework for reinforcing agricultural water resilience under climate risks and change in Burkina Faso." International Journal of Climate Change Strategies and Management 9, no. 1 (January 9, 2017): 68–86. http://dx.doi.org/10.1108/ijccsm-11-2015-0154.
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Purpose This paper aims to propose, for the very first time in Burkina Faso, a “no regret” reference tool to improve policies and processes which could strengthen agricultural water resilience under climate risks and change for sustained food security. Such a framework consists of five pillars derived from the agricultural water vulnerability analysis. Design/methodology/approach The method combined a new designed tool “ClimProspect”, adapted to the Sahelian climatic context, participatory and analogue approaches. Findings Innovative “no regret” framework to overcome current and future climate risks on agricultural water requirements has been built. Research limitations/implications The paper proposes a new way to assess vulnerability and build resilience for a given system and brings climate and disaster risks together. In fact, in the country, disaster and climate risks are closely associated. Practical implications The proposed measures will reinforce water security under climate variability and change and disaster risks, boost the farmers’ participation in water governance and secure the adaptation investment for the long term. Social implications Implementing the proposed measures should provide farmers with agricultural water needs at any time over the year, having access to social protection and sustainably increase their food security. Originality/value Method used explicitly allows for paying attention, at the same time, to climate variability and change, disaster risks and social issues. The “no regret” framework is a practical secured tool for policy makers and planners, and it gives them a new way to secure sustainable water requirements.
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Yaroshchuk, Liudmyla, and Yevheniia Tiurina. "Modeling and control of oils and greases adsorptive purification in the changing raw materials mode." Proceedings of the NTUU “Igor Sikorsky KPI”. Series: Chemical engineering, ecology and resource saving, no. 3 (September 30, 2022): 56–68. http://dx.doi.org/10.20535/2617-9741.3.2022.265361.
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The development of the production sphere and transport determines the need for industrial and transport oils and greases regeneration. A feature of production processes for purification waste is the significant unstable properties of raw materials that come in for purification.
An urgent task is to create control systems for the purification of these substances when they arrive with significantly different properties.
The purpose of the study is to improve efficiency of automation systems of adsorption purification by determining relationship between properties of each new batch of raw materials and necessary conditions for its purification.
Analysis of the adsorption purification technology, typical solutions of control systems and raw materials properties made it possible to justify the need to create a special mathematical support for control of the changing raw materials stage.
A control method aimed at achieving this goal is proposed, which is based on the use of a database. The method involves following stages: searching in the database of substances-analogs for new raw materials; statistical studies of the regime parameters array found for analogues; making decisions on correcting tasks for controllers; parameters adaptation specifically to new raw materials; entering facts about properties of new raw materials and relevant parameters into the database.
Statistical studies involve the description of substances properties and the purification process in several forms (types of models) and a gradual change of forms depending on the database capacity. The article provides an example of the algorithm implementation using MS Access.
The results are obtained on the basis of methods of system analysis, statistical studies, control systems design and databases.
The scientific novelty of obtained results is as follows: in singling out the arrival of new raw materials as a separate operation mode of the control object; in the method of forming tasks for controllers using database of analogue raw materials; in the application of various forms of connection between the properties of substances and mode parameters depending on the database capacity.
The obtained results make it possible to increase efficiency of the control systems of waste regeneration productions by reducing time and increasing the accuracy of determining necessary conditions for the processing of various contaminated raw materials.
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Rosca, Adrian Sorin, Nicolae Craciunoiu, Ionut Daniel Geonea, and Leonard Ciurezu Gherghe. "Experimental measurement of the cutting forces and wear of the drill in processing X17CrNi16-2 martensitic stainless steel." Mechanical Sciences 12, no. 1 (March 4, 2021): 269–87. http://dx.doi.org/10.5194/ms-12-269-2021.
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Abstract. For the optimum setup of an industrial manufacturing process, it can be important to know the drilling forces and moments. In many cases, theoretical estimates are not accurate enough, especially when dealing with new materials, and experimental measurements are mandatory. This paper presents the design of a dynamometer comprising a one-spoked wheel elastic component to measure the drilling thrust force and the drilling moment. A finite element analysis was made, using Ansys software, to find the most favorable position for the strain gauges. One set of strain gauges was bonded to spokes to determine the torque, and a second set was bonded to the other two spokes to quantify the axial thrust force. After dynamometer manufacturing, a calibration operation is achieved, and tests are performed by measuring the drilling forces, thrust, and torque on American Iron and Steel Institute (AISI) 1020 steel. The analogue signals from the gauges were recorded using a computer with a data acquisition device. Tool wear is studied, and the results are presented in the paper. A good agreement between results from the literature and computations demonstrates the efficiency and accuracy of this measuring instrument.
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Singh, Swati, Veda P. Pandey, Kusum Yadav, Anurag Yadav, and U. N. Dwivedi. "Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases." Current Protein & Peptide Science 21, no. 11 (December 31, 2020): 1103–42. http://dx.doi.org/10.2174/1389203721666200918152511.
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: Topoisomerases are reported to resolve the topological problems of DNA during several cellular processes, such as DNA replication, transcription, recombination, and chromatin remodeling. Two types of topoisomerases (Topo I and II) accomplish their designated tasks by introducing single- or double-strand breaks within the duplex DNA molecules, and thus maintain the proper structural conditions of DNA to release the topological torsions, which is generated by unwinding of DNA to access coded information, in the course of replication, transcription, and other processes. Both the topoisomerases have been looked at as crucial targets against various types of cancers such as lung, melanoma, breast, and prostate cancers. Conceptually, targeting topoisomerases will disrupt both DNA replication and transcription, thereby leading to inhibition of cell division and consequently stopping the growth of actively dividing cancerous cells. Since the discovery of camptothecin (an alkaloid) as an inhibitor of Topo I in 1958, a number of derivatives of camptothecin were developed as potent inhibitors of Topo I. Two such derivatives of camptothecin, namely, topotecan and irinotecan, have been commonly used as US Food and Drug Administration (FDA) approved drugs against Topo I. Similarly, the first Topo II inhibitor, namely, etoposide, an analogue of podophyllotoxin, was developed in 1966 and got FDA approval as an anti-cancer drug in 1983. Subsequently, several other inhibitors of Topo II, such as doxorubicin, mitoxantrone, and teniposide, were developed. These drugs have been reported to cause accumulation of cytotoxic non-reversible DNA double-strand breaks (cleavable complex). Thus, the present review describes the anticancer potential of plant-derived secondary metabolites belonging to alkaloids, flavonoids and terpenoids directed against topoisomerases. Furthermore, in view of the recent advances made in the field of computer-aided drug design, the present review also discusses the use of computational approaches such as ADMET, molecular docking, molecular dynamics simulation and QSAR to assess and predict the safety, efficacy, potency and identification of these potent anti-cancerous therapeutic molecules.
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Armstrong, Elizabeth, Juli Coffin, Deborah Hersh, Judith M. Katzenellenbogen, Sandra Thompson, Leon Flicker, Meaghan McAllister, et al. "Healing Right Way: study protocol for a stepped wedge cluster randomised controlled trial to enhance rehabilitation services and improve quality of life in Aboriginal Australians after brain injury." BMJ Open 11, no. 9 (September 2021): e045898. http://dx.doi.org/10.1136/bmjopen-2020-045898.
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IntroductionDespite higher incidence of brain injury among Aboriginal compared with non-Aboriginal Australians, suboptimal engagement exists between rehabilitation services and Aboriginal brain injury survivors. Aboriginal patients often feel culturally insecure in hospital and navigation of services post discharge is complex. Health professionals report feeling ill-equipped working with Aboriginal patients. This study will test the impact of a research-informed culturally secure intervention model for Aboriginal people with brain injury.Methods and analysisDesign: Stepped wedge cluster randomised control trial design; intervention sequentially introduced at four pairs of healthcare sites across Western Australia at 26-week intervals.Recruitment: Aboriginal participants aged ≥18 years within 4 weeks of an acute stroke or traumatic brain injury.Intervention: (1) Cultural security training for hospital staff and (2) local, trial-specific, Aboriginal Brain Injury Coordinators supporting participants.Primary outcome: Quality-of-life using EuroQOL-5D-3L (European Quality of Life scale, five dimensions, three severity levels) Visual Analogue Scale score at 26 weeks post injury. Recruitment of 312 participants is estimated to detect a difference of 15 points with 80% power at the 5% significance level. A linear mixed model will be used to assess the between-condition difference.Secondary outcome measures: Modified Rankin Scale, Functional Independence Measure, Modified Caregiver Strain Index, Hospital Anxiety and Depression Scale at 12 and 26 weeks post injury, rehabilitation occasions of service received, hospital compliance with minimum care processes by 26 weeks post injury, acceptability of Intervention Package, feasibility of Aboriginal Brain Injury Coordinator role.Evaluations: An economic evaluation will determine the potential cost-effectiveness of the intervention. Process evaluation will document fidelity to study processes and capture changing contexts including barriers to intervention implementation and acceptability/feasibility of the intervention through participant questionnaires at 12 and 26 weeks.Ethics and disseminationThe study has approvals from Aboriginal, university and health services human research ethics committees. Findings will be disseminated through stakeholder reports, participant workshops, peer-reviewed journal articles and conference papers.Trial registration numberACTRN12618000139279.
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Velcheva, Vyara, Kaspar Hegetschweiler, Georgi Momekov, Stefka Ivanova, Angel Ugrinov, Bernd Morgenstern, and Galina Gencheva. "Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates." Pharmaceutics 14, no. 10 (September 27, 2022): 2057. http://dx.doi.org/10.3390/pharmaceutics14102057.
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Metal complexes occupy a special place in the field of treatment and diagnostics. Their main advantages stem from the possibility of fine-tuning their thermodynamic properties and kinetic behavior in the biological milieu by applying different approaches such as properly constructed inner coordination sphere, appropriate choice of ligands, metal oxidation state, redox potential, etc., which are specific to these compounds. Here we discuss the design and synthesis of two octahedral cationic Pt(IV) complexes of the tridentate ligand all-cis-2,4,6-triaminocyclohexane-1,3,5-triol (taci) with composition, fac-[Pt(taci)I3]+, 1 and bis-[Pt(taci)2]4+, 2 as well as the potential for their application as antineoplastic agents. The complexes have been isolated in a solid state as: fac-[Pt(taci)I3]I·3H2O (1A), fac-[Pt(taci)I3]I (1B), fac-[Pt(taci)I3]I·2DMF (1C), bis-[Pt(taci)2](CO3)2·6H2O (2A) by changing the acidity of the reaction systems, the molar ratios of the reagents and the counterions, and by re-crystallization. The ligand taci is coordinated through the NH2-groups, each molecule occupying three coordination places in the inner coordination sphere of Pt(IV). Monitoring of the hydrolysis processes of 1A and 2A at different acidity showed that while 2A remained stable over the study period, the I−-ions in 1A were successively substituted, with the main product under physiologically mimetic conditions being fac,cis-[Pt(taci)I(OH)2]+ (h2). The antiproliferative tests involved eight cancer cell models, among which chemosensitive (derived from leukemias and solid tumors) and chemoresistant human Acute myeloid leukemia lines (HL-60/Dox, HL-60/CDDP), as well as the non-malignant kidney’ cells HEK-293T showed that the complexes 1A and 2A are characterized by a fundamentally different profile of chemosensitivity and spectrum of cytotoxic activity compared to cisplatin. The new Pt(IV) complexes were shown to be more effective in selectively inhibiting the proliferation of human malignant cells compared to cisplatin. Remarkable activity was recorded for 1A, which showed an effect (IC50 = 8.9 ± 2.4) at more than 16-fold lower concentration than cisplatin (IC50 = 144.4 ± 9.8) against the resistant cell line HL-60/CDDP. In parallel, 1A exhibited virtually the same cytotoxic effect against the parental HL-60 cells (IC50 = 9.0 ± 1.2), where cisplatin displays comparable chemosensitivity (IC50 = 8.3 ± 0.8). The determined resistance indices (RI~1) show unequivocally that the resistant lines are sensitive to both compounds tested; therefore, they are capable of overcoming the mechanisms of cisplatin resistance. The structural features of these compounds and their promising pharmacological properties justify their inclusion in the group of “non-classical metal-based antitumor compounds” and are a prerequisite for the admission of alternative mechanisms of action.
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Mbhele, Thokozani Patmond, and Praveena Ramnandan. "THE DIGITAL ECOSYSTEM AND ENTREPRENEURIAL MUSIC DISTRIBUTION: A FORCE FIELD PERSPECTIVE." Acta Tecnología 6, no. 4 (December 31, 2020): 89–103. http://dx.doi.org/10.22306/atec.v6i4.87.
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The world of business has evolved from the 19th century (steam, rail and electricity) to the 20th century (telephone, radio, television and, especially, the computer as the greatest information technology that converts analogue signals into a digital form including binary digits), and the 21st century (the fourth industrial revolution (4th IR) – described as the advent of “cyber-physical systems” involving entirely new capabilities for people and machines). Digital entrepreneurship is an emergent phenomenon in which new digital artefacts, platforms and infrastructure are used to pursue innovative and entrepreneurial opportunities, which, to a certain extent calls into questions the relevance and applicability of traditional understandings of entrepreneurship. The study on which this article is based investigated digital entrepreneurship’s impact on the dynamic social networking market in light of the infusion of disruptive and innovative technology. It aimed to determine the entrepreneurship capability and competence that impact on digital music change management; and to examine the extent to which digital music distribution balances the driving forces of digitisation and the restraining forces from disruptive technology. An exploratory research design was adopted using univariate, bivariate and multivariate statistical analysis techniques to analyse the data collected from 217 musicians. The study found that the Internet is capable of reliable delivery of music processes, products and services, thereby enhancing supply chain distribution competence and capability. Digital entrepreneurial innovations enable independent artists to create music according to their tastes and customer demand. Independent music production and creation drive the economic entrepreneurial dimension while technological advancements encourage digital independent music distribution.
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Ivanov, Evgeniy Gennadievich, Boris Ivanovich Gorbunov, Alexander Valentinovich Pasin, Boris Alexandrovich Aryutov, and Alexei Ivanovich Novozhilov. "Augmentation of Vortex Cavitator Performance by the Use of Co-Directional Swirl of the Flux after Vortex Chamber." Progress in Agricultural Engineering Sciences 15, no. 1 (December 2019): 1–22. http://dx.doi.org/10.1556/446.15.2019.1.1.
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Abstract Background: Acoustic cavitation is the creation and collapse of cavitation caverns in liquid in an acoustic field with a frequency of f = 1–3 kHz. The acoustic-cavitation processes manifest themselves during the collapse phase, with high pressure gradient continuum deformation, with a multiple transformation of energy forms. Liquid whistles are widely used to create an acoustic field of high power, but their efficiency only reaches 6–12%. We propose a liquid whistle in the form of a vortex cavitator (analogue of the Ranque vortex tube) with a rotating body in which a reduction in the input power is predicted. Objective: Verification of feasibility of using a rotating body in a vortex cavitator with a rotation co-directional to the operational pump impeller. Method: The method for identifying the feasibility of using a rotating body is to exclude body from the prototype and directly connect vortex chamber outlet with the pump inlet, which ensures the most complete preservation of co-directional vortex component of the flux entering the pump impeller. Results: The results of experimental studies confirmed the validity of the hypothesis to a greater extent, since we achieved an increase in pressure at the outlet of the pump and a decrease in power at the drive relative to the original design. Conclusions: The feasibility of designing the vortex cavitator body with rotation capability has been established, which will provide a reduction in input power of at least 30% by a rotation of the body, co-directional with the impeller.
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Rummo, V., and Y. Rabotin. "INFORMATION AND ANALYTICAL SUPPORT OF SAFE-ORIENTEERING DEVELOPMENT OF PRODUCTION SYSTEMS IN FOOD INDUSTRY." Market economy: modern management theory and practice 20, no. 1(47) (March 24, 2021): 234–52. http://dx.doi.org/10.18524/2413-9998.2021.1(47).236795.
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The article is devoted to the development of improved information and analytical support for the design of several options for production processes in the food industry, which are implemented both with the same and with different options for a set of technologically specialized structural units of the enterprise. When choosing the option of safe-oriented development of the production system, the criteria of minimum financial costs, minimum time costs, maximum load of structural units were used. To solve the problems of forming a virtual safe-oriented development of production systems at enterprises that are part of a network organizational form, an algorithm for evaluating potential partners based on an analogue of a multifactor matrix model is presented. First, each potential partner is assessed according to the characteristics of technological compliance and production capacity. At the next stage, each potential partner is assessed according to the characteristics of the current load and production capacity, and then according to the characteristics of the technological level and production potential. For a comprehensive assessment of each technology partner, the position in the matrices of correspondence, load, efficiency is determined and belongs to one of the selected ten groups. This approach makes it possible to select and propose the main and additional performers for additional investments in the safe development of production systems and the implementation of unique production operations or events. This approach also makes it possible to carry out a sustainable, safe development of production systems in the food industry in crisis conditions of the economy from a scientifically grounded standpoint.
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Aulinas, Anna, Reitumetse L. Pulumo, Elisa Asanza, Christopher J. Mancuso, Meghan Slattery, Christiane Tolley, Franziska Plessow, et al. "Endogenous Oxytocin Levels in Relation to Food Intake, Menstrual Phase, and Age in Females." Journal of Clinical Endocrinology & Metabolism 104, no. 4 (November 16, 2018): 1348–56. http://dx.doi.org/10.1210/jc.2018-02036.
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Abstract Context Oxytocin regulates a range of physiological processes including eating behavior and oxytocin administration reduces caloric intake in males. There are few data on oxytocin and eating behavior in healthy females or on the response of endogenous oxytocin to food intake and its relationship to appetite in humans. Objectives To determine the postprandial pattern of oxytocin levels, the relationship between oxytocin and appetite, and the impact of menstrual cycle phase and age on oxytocin levels in females. Design Cross-sectional. Setting Clinical research center. Participants Fifty-five healthy females (age 10 to 45 years). Interventions A standardized mixed meal was administered. Main Outcome Measurements Blood sampling for oxytocin occurred at fasting and at 30, 60, and 120 minutes postmeal. Appetite was assessed using Visual Analogue Scales pre- and postmeal. Results Mean fasting oxytocin levels were 1011.2 ± 52.3 pg/mL (SEM) and decreased at 30 and 60 minutes postmeal (P = 0.001 and P = 0.003, respectively). Mean oxytocin levels decreased19.6% ± 3.0% from baseline to nadir. Oxytocin area under the curve was lower in the early to midfollicular menstrual cycle phase (P = 0.0003) and higher in younger females (P = 0.002). The percent change in oxytocin (baseline to nadir) was associated with postprandial hunger (rs = -0.291, P = 0.03) and fullness (rs = 0.345, P = 0.009). These relations remained significant after controlling for calories consumed, menstrual cycle status, and age (P = 0.023 and P = 0.0001, respectively). Conclusions Peripheral oxytocin levels in females decrease after a mixed meal and are associated with appetite independent of menstrual phase, age, and caloric intake, suggesting that endogenous oxytocin levels may play a role in perceived hunger and satiety.
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Ginslov, Jeannette. "The poetics of temporal scaffolding and porosity: sharing affect and memory[Jeannette Ginslov]." Repertório, no. 28 (December 5, 2017): 222. http://dx.doi.org/10.9771/r.v0i28.25008.
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<p class="p1">Abstracts:</p><p class="p2"><span class="s1"><em>P(AR)ticipate: body of experience/body of work/body as archive </em>and <em>AffeXity </em>are two AR (Augmented Reality) and Screendance works that attempt to capture, amplify and share affect and memory using AR, mobile phones and audience participation. <em>P(AR)ticipate</em> is an immersive, autobiographical, participatory and live installation work comprising: text, analogue hieroglyphs and gestural Screendance videos, tagged to the hieroglyphs, using the AR app Aurasma, within an interaction design. The work explores the porosity between analogue and augmented gestures, personal somatic memories and mediated experiences, of living in an apartheid and democratic South Africa. <em>AffeXity</em> on the other hand, is an interdisciplinary choreographic project examining affect, dance on screen and cities. <em>AffeXity</em>, a play on both ‘affect city’ and ‘a-fixity’. It is a collaborative project drawing together dance, visual imagery, AR and mobile phones, that audiences use for the viewing of choreographies embedded on tags in the city of Copenhagen Denmark. The project now forms part of the <em>Living Archives Research Project </em>at Malmö University. This paper describes the process and methodologies of capturing affective choreographies and memory on video, on analogue hieroglyphs and the processes of sharing them within interaction AR designs. It also describes the collaborative processes involved in both projects that attempt to allow audiences with mobile devices, to extrapolate hidden layers of affect and memory using networked mobile technology. These projects may shape choreographic formations that have not yet been explored and “is a specialised and evolving form - where the choreographic language is interrogated not for form or content sake, but in response to the changing stimuli and physical liberties of the technology itself.” (KRIEFMAN, 2014). This consequentially liberates the choreographic content and language from more traditional vocabularies, narratives and settings, to poetic ones. Above all, the paper investigates the archiving of affect within a relational and dialogical field, of “unfolding the self into the world, whist enfolding the world within” (BRAIDOTTI, 2013). It explores how we anchor our bodies to the world</span><span class="s1">(GREGG and SEIGWORTH 2010 cited in KOZEL, 2012) and how these “messy encounters become platforms for the transmission of affect (and memory) across bodies that themselves exist across layers of mediatization” (KOZEL, 2013).</span></p><p class="p3"><span class="s1">Keywords: </span>Haptics. Affect. Temporal Scaffolding. Screendance. Augmented Reality.<span class="Apple-converted-space"> </span></p><p class="p3"><span class="Apple-converted-space"><br /></span></p><p>A POETICA DA ESTRUTURA TEMPORAL E DA POROSIDADE: COMPARTILHANDO AFETOS E MEMÓRIAS</p><p class="p1"><em>Resumo:</em></p><p class="p2"><span class="s1"><em>P(AR)ticipate: corpo de experiência / corpo de trabalho / corpo como arquivo e AffeXity são dois trabalhos de AR (Realidade Aumentada) e videodança que tentam capturar, amplificar e compartilhar afetos e memória usando AR, telefones celulares e participação do público . O P(AR)ticipate é um trabalho de instalação imersiva, autobiográfica, participativa e ao vivo que inclui: texto, hieróglifos analógicos e videodanças gestuais, marcados aos hieróglifos, usando o aplicativo Aurasma de realidade aumentada, dentro de um projeto de interação.O trabalho explora a porosidade entre gestos analógicos e aumentados, memórias somáticas pessoais e experiências mediadas, de viver em uma África do Sul democrática e com segregação racial. A AffeXity, por outro lado, é um projeto coreográfico interdisciplinar que analisa afeto, dança na tela e cidades. AffeXity é uma peça em “afetar cidade” e “a-fixidade”. É um projeto colaborativo que reúne dança, imagens visuais, AR e telefones celulares, que o público usa para a visualização de coreografias embutidas em tags na cidade de Copenhague, Dinamarca. O projeto agora faz parte do Projeto de Pesquisa de Arquivos Vivos na Universidade de Malmö. Este artigo descreve o processo e metodologias de captura de coreografias afetivas e memória em vídeo, hieróglifos analógicos e os processos de compartilhá-los em projetos de interação em AR. Ele também descreve os processos colaborativos envolvidos em ambos os projetos que tentam permitir audiências com dispositivos móveis, para extrapolar camadas ocultas de afeto e memória usando a tecnologia móvel em rede. Esses projetos podem moldar formas coreográficas que ainda não foram exploradas e “é uma forma especializada e em evolução”, onde a linguagem coreográfica é interrogada não por causa de forma ou conteúdo, mas em resposta aos estímulos em mudança e às liberdades físicas da própria tecnologia “. (KRIEFMAN, 2014). Consequentemente, isso libera o conteúdo coreográfico e o idioma de vocabulários, narrativas e configurações mais tradicionais para conteúdos mais poéticos. Sobretudo, o artigo investiga o arquivamento do afeto dentro de um campo relacional e dialógico, de “desdobrar o eu o mundo, envolvendo o próprio mundo”(BRAIDOTTI, 2013). Ele explora como ancoramos nossos corpos para o mundo (GREGG e SEIGWORTH 2010 citado em KOZEL, 2012) e como esses” encontros confusos se tornam plataformas para transmissão de afetos ( e memória) em corpos que existem em camadas de mediatização “(KOZEL, 2013)</em></span></p><p class="p3"><span class="s1"><em>Palavras-chave: </em></span><em>Háptico. Afeto. Estrutura Temporal. Videodança. Realidade aumentada.</em></p>