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1

Sinatra, Raymond S., Jonathan S. Jahr, and J. Michael Watkins-Pitchford, eds. The Essence of Analgesia and Analgesics. Cambridge: Cambridge University Press, 2009. http://dx.doi.org/10.1017/cbo9780511841378.

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2

Casy, Alan F., and Robert T. Parfitt. Opioid Analgesics. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4899-0585-7.

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3

Tamerius, Rita. Effective pain management. 5th ed. La Mesa, CA: Western Schools Press, 1994.

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4

Jacobs, Vivian, and Alexander Lang. Analgesics: New research. Hauppauge, N.Y: Nova Science Publishers, 2011.

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5

W, Houde Raymond, Ley Timothy J, and Hollister Leo E. 1920-, eds. Analgesics and NSAID. Mount Kisco, N.Y: Futura Pub. Co., 1985.

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6

Rodgers, Joann Ellison. Drugs & pain. New York: Chelsea House Publishers, 1987.

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7

Rodgers, Joann Ellison. Drugs & pain. New York: Chelsea House Publishers, 1987.

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8

Sneader, Walter. Analgesics for internal use. Glasgow: University of Strathclyde, Continuing Education Centre, 1985.

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9

T, Parfitt Robert, ed. Opioid analgesics: Chemistry and receptors. New York: Plenum Press, 1986.

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10

(Firm), Packaged Facts, ed. The Analgesic market. New York, N.Y. (581 Ave. of the Americas, New York 10011): Packaged Facts, 1990.

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11

Freye, Enno. Opioid agonists, antagonists and mixed narcotics analgesics: Theoretical background and considerations for practical use. Berlin: Springer, 1987.

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12

Freye, Enno. Opioid Agonists, Antagonists and Mixed Narcotic Analgesics. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71854-0.

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13

Masuda, Quamrun Nahar. The stability and formulation of topical analgesics. Birmingham: University of Aston. Department of Pharmaceutical Sciences, 1985.

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14

1950-, Sawynok Jana, and Cowan Alan 1942-, eds. Novel aspects of pain management: Opioids and beyond. New York: Wiley-Liss, 1999.

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15

Loes, Michael. The Aspirin alternative: The natural way to overcome chronic pain, reduce inflammation and enhance the healing response. Topanga, CA: Freedom Press, 1999.

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16

Omoigui, Sota. Sota Omoigui's pain drugs handbook. 2nd ed. Malden, MA: Blackwell Science, 1999.

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17

Flecknell, P. A., and Avril Waterman-Pearson. Pain management in animals. London: W.B. Saunders, 2000.

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18

United States. Agency for Health Care Policy and Research, ed. Managing cancer pain: Management of cancer pain : patient guide. Rockville, MD] (Executive Office Center, Suite 501, 2101 East Jefferson St., Rockville 20852): U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, 1994.

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19

Marcovitz, Hal. Painkillers. San Diego, CA: Daniel A. Leone, Publisher, 2009.

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20

Barlas, Uğurol. Anadolu halk hekimliğinde geleneksel ağrı kesiciler: Traditional painkillers in Anatolian folk medicine. İstanbul: Piya Art Yayınları, 2020.

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21

Bristol-Myers Squibb Symposium on Pain Reseaech (4th 1993 Monterey, Calif.). Pharmacological approaches to the treatment of chronic pain: New concepts and critical issues : the Bristol-Myers Squibb Symposium on Pain Research. Edited by Field Howard L. 1928- and Liebeskind John C. Seattle: IASP Press, 1994.

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22

Marcovitz, Hal. Painkillers. San Diego, CA: Daniel A. Leone, Publisher, 2009.

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23

Parks, Peggy J. The dangers of painkillers. San Diego, CA: ReferencePoint Press, Inc., 2017.

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24

Brune, K., ed. New Pharmacological and Epidemiological Data in Analgesics Research. Basel: Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-6387-2.

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25

1944-, Foley Kathleen M., and Inturrisi Charles E, eds. Opioid analgesics in the management of clinical pain. New York: Raven Press, 1986.

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26

Jahr, Jonathan S., Raymond S. Sinatra, and J. Michael Watkins-Pitchford. Essence of Analgesia and Analgesics. Cambridge University Press, 2010.

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27

Jahr, Jonathan S., Raymond S. Sinatra, and J. Michael Watkins-Pitchford. Essence of Analgesia and Analgesics. Cambridge University Press, 2010.

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28

Jahr, Jonathan S., Raymond S. Sinatra, and J. Michael Watkins-Pitchford. Essence of Analgesia and Analgesics. Cambridge University Press, 2010.

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29

Jahr, Jonathan S., Raymond S. Sinatra, and J. Michael Watkins-Pitchford. Essence of Analgesia and Analgesics. Cambridge University Press, 2010.

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30

Patel, Mayur B., and Pratik P. Pandharipande. Analgesics in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0043.

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Analgesia is a critical component of intensive care unit (ICU) care. Accordingly, understanding the mechanism, physiological consequences, and assessment of pain is important when caring for the ICU patient. Non-pharmacological approaches should be attempted before supplementing analgesia with pharmacological agents. Pharmacologically-based therapies are divided into regional and systemic therapies. Regional analgesic therapies target specific areas of the body while limiting the systemic effects of intravenous analgesics, but at the risk of invasiveness, local anaesthetic toxicity, and infection of in-dwelling catheters. Systemic analgesic therapy is comprised of two main categories—non-opioids and opioids. Typically, non-opioid analgesics are used as adjunctive therapies and consist of agents such as non-steroidal anti-inflammatory drugs, gabapentinoids, ketamine, or α‎2 agonists. Opioid analgesia in the ICU is commonly infusion-based using fentanyl, hydromorphone, morphine, or recently, remifentanil.
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31

The Essence Of Analgesia And Analgesics. Cambridge University Press, 2010.

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32

Foo, Joanne, Benazir Saleem, and Philip G. Conaghan. Analgesics. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0078.

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Pain is one of the commonest presenting symptoms of musculoskeletal disorders and may be one the hardest to treat successfully. The available analgesic options provide different modes of action and their ranks continue to expand with new agents, some with multiple target action. This chapter reviews currently available analgesics (paracetamol and opioids) used for managing musculoskeletal pain and the agents used for neuropathic pain, including their mechanism of action, pharmacokinetics and side effects. The role of neuroleptic agents is reviewed, and a brief outline of some newer therapies for the treatment of pain such as tapentadol, and a potential therapy, anti-nerve growth factor monoclonal antibodies.
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33

Hatfield, Anthea. Analgesics. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199666041.003.0007.

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Analgesics are drugs used to relieve pain. They are divided into groups: opioids, non-steroidals, and adjuvants. This chapter gives you detailed information on their pharmacology. Once you fully understand the chemistry of these drugs you can go on to understand their clinical properties, how they react differently in different groups of people, and their side effects.
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34

Buschmann, Helmut, Thomas Christoph, Corinna Maul, and Bernd Sundermann, eds. Analgesics. Wiley, 2002. http://dx.doi.org/10.1002/3527605614.

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35

Analgesics. 2003.

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36

Pleuvry, Barbara, and Alex Pleuvry. Analgesics. Urch Publishing Ltd, 1999.

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37

Lussier, David, and Russell K. Portenoy. Adjuvant analgesics. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0097.

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In the management of pain associated with serious illness, ‘adjuvant analgesics’ usually are administered in concert with opioid therapy in an effort to improve outcomes when an opioid does not provide satisfactory relief with tolerable side effects. They may be divided into categories, including multipurpose drugs, and drugs used selectively for neuropathic pain, bone pain, pain due to bowel obstruction, or musculoskeletal pain. These drugs are selected for a trial based on limited data available and clinical experience; sequential trials may be undertaken when pain is refractory. Multipurpose drugs may be considered for any type of pain. The most useful include corticosteroids and analgesic antidepressants. For neuropathic pain, conventional first-line agents are gabapentinoids, analgesic antidepressants, and corticosteroids. Corticosteroids and bisphosphonates, are used commonly for bone pain. The indications and dosing strategies for these drugs are evolving as scientific evidence and clinical experience accumulate.
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38

Beaulieu, Pierre, and David Lussier. Adjuvant Analgesics. Oxford University Press, Incorporated, 2015.

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39

Adjuvant Analgesics. Oxford University Press, Incorporated, 2015.

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40

Adjuvant Analgesics. Oxford University Press, Incorporated, 2015.

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41

Abdel-Salam, Omar M. E. Capsaicin As a Therapeutic Molecule. Springer London, Limited, 2014.

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42

Capsaicin As a Therapeutic Molecule. Springer, 2014.

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43

Sjøgren, Per, Frank Elsner, and Stein Kaasa. Non-opioid analgesics. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0096.

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Non-opioid analgesics encompass the non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen). The NSAIDs include acetylsalicylic acid (ASA, aspirin), dipyrone (metamizole), and numerous other drugs in diverse classes. The NSAIDs have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. In palliative medicine, they represent the first step of the World Health Organization’s analgesic ladder used for mild pain and they are an important supplement to opioids and adjuvant drugs at higher steps of the ladder. The disadvantages of non-opioid analgesics include a ceiling effect for pain relief and the risk of side effects. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal, and cardiovascular effects and hepatotoxicity can result from overdosing with paracetamol. This chapter describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
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44

Janssen, Paul A. J., D. H. R. Barton, and W. Doering. Synthetic Analgesics: Diphenylpropylamines. Elsevier Science & Technology Books, 2014.

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45

Fundamentals of Anaesthesia. Cambridge University Press, 2017.

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46

Williams, John, and Francis Bonnet. Analgesics in anaesthetic practice. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0018.

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Each year, approximately 230 million major surgical procedures are undertaken worldwide, with over three-quarters of the patients complaining of pain postoperatively and 10% complaining of severe pain. Pain is not, however, just an unpleasant sensory consequence of surgery, but can also have significant physiological implications impacting negatively on well-being and postoperative outcome. Postoperative pain may also result in changes within the central nervous system, leading to the development of chronic pain states lasting in excess of 3–6 months. Adequate analgesia has proven to be effective when employed in the perioperative period at combating many of these adverse effects. An understanding of the basic physiological and pharmacological mechanisms responsible for producing, transmitting, and sustaining pain has allowed for a variety of effective analgesic agents to be fashioned and used clinically to treat pain. Morphine, the archetypal opioid analgesic, is the most familiar of these agents with a long history of use and evidence of effectiveness; morphine possesses a number-needed-to-treat (NNT) to reduce pain by 50% of around 3 when given in doses of between 10 and 15 mg. Non-steroidal agents and paracetamol are similarly effective in the immediate postoperative period with NNTs of between 2 and 4. More recently, a number of analgesic adjuncts such as gabapentin, pregabalin, ketamine, clonidine, and nefopam have found favour for the treatment of acute postoperative pain. None of these agents, however, are without side-effects, ensuring that the search for effective analgesic agents continues to be a vibrant area of research with new analgesic agents continuing to be developed.
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47

Esherick, Joseph S. Tarascon Primary Care: Analgesics. Jones & Bartlett Learning, LLC, 2009.

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48

BRUNE and SANTOSO. Antipyretic Analgesics : New Insights. Birkhauser, 1992.

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49

Hellerbach, J., O. Schnider, H. Besendorf, W. Von Doering, and D. H. R. Barton. Synthetic Analgesics : Morphinans: Benzomorphans. Elsevier Science & Technology Books, 2014.

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50

Castro, J. de, Michael Zenz, and J. Meynadier. Regional Opioid Analgesia: Physiopharmacological Basis, Drugs, Equipment and Clinical Application. Springer, 2012.

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