Academic literature on the topic 'Analgesia'

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Journal articles on the topic "Analgesia"

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Lukito, Johan Indra. "Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut." Cermin Dunia Kedokteran 50, no. 9 (September 1, 2023): 509–15. http://dx.doi.org/10.55175/cdk.v50i9.868.

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Konsep analgesia multimodal dianjurkan untuk pengobatan nyeri. Paracetamol dan nonsteroidal antiinflammatory drugs (NSAID) umumnya menjadi analgesik dasar, serta dikombinasikan dengan opioid sesuai kebutuhan. Analgesik intravena (IV) dapat menjadi solusi bagi pasien yang tidak dapat menerima analgesik per oral. Kombinasi paracetamol dan ibuprofen IV menunjukkan efek analgesik yang signifikan, dengan manfaat opioid sparing, antipiretik, serta dengan profil keamanan yang relatif baik pada pasien nyeri akut. The concept of multimodal analgesia is recommended for the treatment of pain. Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are generally the basic analgesics, and are combined with opioids as needed. Intravenous (IV) analgesics may serve as an alternative for patients who cannot tolerate oral analgesics. The IV combination of paracetamol and ibuprofen for acute pain shows a significant analgesic effect with the benefits of opioid sparing, also with antipyretic effect, and with a relatively good safety profile.
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Fürst, Susanna, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, et al. "On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance." Molecules 25, no. 11 (May 26, 2020): 2473. http://dx.doi.org/10.3390/molecules25112473.

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There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, chronic treatment with opioid analgesics induces central analgesic tolerance, thus limiting their clinical usefulness. Numerous molecular mechanisms, including receptor desensitization, G-protein decoupling, β-arrestin recruitment, and alterations in the expression of peripheral MORs and microbiota have been postulated to contribute to the development of opioid analgesic tolerance. However, these studies are largely focused on central opioid analgesia and tolerance. Accumulated literature supports that peripheral MORs mediate analgesia, but controversial results on the development of peripheral opioid receptors-mediated analgesic tolerance are reported. In this review, we offer evidence on the consequence of the activation of peripheral MORs in analgesia and analgesic tolerance, as well as approaches that enhance analgesic efficacy and decrease the development of tolerance to opioids at the peripheral sites. We have also addressed the advantages and drawbacks of the activation of peripheral MORs on the sensory neurons and gut (leading to dysbiosis) on the development of central and peripheral analgesic tolerance.
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Tantri, Aida Rosita, Riyadh Firdaus, Hansen Angkasa, Ahmad Pasha Natanegara, and Muhammad A. I. Maulana. "Pre-emptive versus preventive analgesia for postoperative pain: a systematic review and meta-analysis." Universa Medicina 42, no. 2 (June 22, 2023): 227–39. http://dx.doi.org/10.18051/univmed.2023.v42.227-239.

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BackgroundPostoperative pain is a type of nociceptive pain that originates from tissue damage due to trauma caused by surgery. Pre-emptive analgesia is treatment that starts before surgery, to prevent or reduce the establishment of sensitization of dorsal horn neurons caused by tissue injury, the sensitized neurons being supposed to amplify postoperative pain. Pre-emptive analgesia consists of administering analgesic medication before tissue injury, that is, before the reception, transmission, modulation, and nociception of the aggressive stimulus, aiming to prevent hyperalgesia. This review aims to compare the efficacy of pre-emptive analgesia and preventive analgesia in postoperative pain. MethodsArticle searching was done on five databases (PubMed, ProQuest, Scopus, ScienceDirect, ClinicalKey). Hand-searching was also done to find additional articles. We have only included double-blind, randomized, controlled trials (RCT). A total of fifteen articles were included and all were RCT studies comparing pre-emptive analgesia with preventive analgesia. The quality of the included studies was evaluated with Cochrane risk-of-bias assessment tools. Quantitative analysis was performed by Review Manager 5.4. ResultsFifteen studies comprising 830 subjects were included in this study. Our analysis revealed that pre-emptive analgesia significantly improved visual analog scale (VAS)/numeric rating scale (NRS)/verbal rating scale (VRS) 4 hours postoperatively [mean difference (MD) = -0.25, 95% CI: [- 0.49, -0.02]; I2 = 94%]. Unfortunately, pain scoring at 6, 12 and 24 hours after surgery did not differ significantly between pre-emptive and preventive analgesia. Duration of analgesia was comparable between the two groups. Time to rescue analgesics was similar between the two groups, but the pre-emptive group was associated with less analgesic consumption postoperatively than the preventive group. ConclusionPre-emptive analgesia provided better pain relief than preventive analgesia during the short term. Time to rescue analgesics is comparable between both groups, but pre-emptive analgesia is associated with lower amounts of rescue analgesics postoperatively.
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Wellington, Nancy, and Michael J. Rieder. "Attitudes and Practices Regarding Analgesia for Newborn Circumcision." Pediatrics 92, no. 4 (October 1, 1993): 541–43. http://dx.doi.org/10.1542/peds.92.4.541.

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Study objective. To determine attitudes regarding routine use of analgesia for newborn circumcision among primary care physicians in southwestern Ontario. Design. Questionnaire survey conducted among all family physicians and pediatricians belonging to the London Academy of Medicine. The majority of pediatric primary care in this region is provided by family physicians. Setting. Metropolitan center in Southwestern Ontario. Respondents. A questionnaire was mailed to 279 physicians; 171 (61%) responded. Results. Seventy-four (43%) respondents performed circumcisions. Among physicians performing circumcisions, a minority (17; 24%) used any form of analgesia. The most commonly used analgesic (14; 20%) was oral ethanol. Only 3 (4%) physicians used dorsal penile nerve block. The most common reasons listed for not employing analgesia were lack of familiarity with analgesia use among neonates (56%), lack of familiarity with the technique of dorsal penile block (50%), and concern over adverse effects of analgesic drugs (49%) and regional analgesia (44%). Only a small minority of physicians (7; 12%) responded that they believe that neonates do not feel pain, and 20 (35%) believe that neonates do not remember pain. Conclusions. Despite evidence that neonates perceive pain and that there is a physiologic stress response to circumcision which can be reduced if analgesia is employed, the vast majority of physicians performing newborn circumcisions either do not employ analgesics or employ analgesics of questionable efficacy. Lack of familiarity with the use of analgesics among neonates and with dorsal penile block in particular are the most common reasons cited for lack of analgesic use. Educational efforts and research into less invasive techniques of analgesia for newborn circumcision are urgently required.
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Dmytriev, Dmytro, Oleksandr Nazarchuk, and Yuliana Babina. "Metoxifluran, an inhalation analgesic that opens up new possibilities in anesthesia." Pain medicine 8, no. 1-2 (October 4, 2023): 9–16. http://dx.doi.org/10.31636/pmjua.v8i1-2.2.

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Although numerous clinical guidelines for pain management have been published over the past decade, inadequate pain relief remains a major public health problem. Currently, several methods of analgesia are available for the treatment of acute pain, including intravenous analgesia, epidural anesthesia, and oral administration of medications. However, the existing methods of analgesia still do not cover all the needs of proper analgesia, the search for new forms of release, methods of administration and methods of analgesia continues. Currently, non-invasive methods of analgesia are being actively implemented, which include a transdermal delivery system of analgesics (in particular, fentanyl hydrochloride), intranasal and inhalational analgesia, in which the delivery of analgesics is controlled by both the doctor and the patient. The purpose of this article is to review the inhaled analgesic methoxyflurane, which is administered by means of an individual inhaler and is used for the treatment of acute pain.
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Furumoto, Kayo, Kumi Ogita, Tomomi Kamisaka, Asami Kawasumi, Koushi Takata, Noritaka Maeta, Takamasa Itoi, Masakatsu Nohara, Kaori Saeki, and Teppei Kanda. "Effects of Multimodal Analgesic Protocol, with Buprenorphine and Meloxicam, on Mice Well-Being: A Dose Finding Study." Animals 11, no. 12 (November 30, 2021): 3420. http://dx.doi.org/10.3390/ani11123420.

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The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR male mice were divided into control, anesthesia + analgesia, and surgery + anesthesia + analgesia groups. Tap water (orally: PO) and water for injection (subcutaneous: SC) were administered to the control group. Buprenorphine was administered twice (SC, 0.1 mg/kg/8 h) and meloxicam was administered thrice (PO, 5 mg/kg/24 h) to the anesthesia + analgesia and surgery + anesthesia + analgesia groups. The mice were subjected to laparotomy and assessed for several parameters. Even in absence of surgical pain, the anesthesia + analgesia group presented the same negative effects as the surgery + anesthesia + analgesia group. This multimodal analgesic protocol for mice was expected to have an analgesic effect on pain associated with laparotomy but was not sufficient to prevent food intake and weight decrease. This does not negate the need to administer analgesics, but suggests the need to focus on and care not only about the approach to relieve pain associated with surgery, but also other types of distresses to minimize negative side effects that may interfere with postoperative recovery in mice.
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Tumanyan, Sergey V., Oleg I. Kit, Elena M. Frantsiyants, Tatiana I. Moiseenko, Oksana V. Oros, and Elizaveta Yu Sugak. "Non-opioid analgesics: New opportunities in early rehabilitation of patients with gynecological cancer." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e17129-e17129. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17129.

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e17129 Background: An important principle of analgesia is its effect on each component of the pain formation. The purpose of the study was to improve analgesia in the perioperative period in patients with gynecological cancer. Methods: This prospective randomized study of the quality and effectiveness of various analgesics included 97 patients aged 22-67 years receiving surgery for gynecological cancer. The patients were divided into two groups. Group 1 (n = 47): patient-controlled analgesia with trimeperidine and nonsteroidal anti-inflammatory drugs (NSAIDs); group 2 (n = 50): preemptive analgesia based on lidocaine, magnesium sulphate, nefopam and NSAIDs. Results and pain syndrome were assessed by levels of glucose, cortisol, insulin, lactate, C-reactive protein (CRP), Kerdo autonomic index, visual analogue scale (VAS), levels of personal and reactive anxiety and depression. Results: Analgesic effect of trimeperidine was obtained in 83.3% (p < 0.05). However, the effect was less pronounced, compared to non-opioid analgesics, and did not reduce the psychosomatic component of pain after surgical treatment. In group 2, non-opioid analgesia limited the increase of cortisol, glucose, insulin, CRP and lactate (p < 0.05) providing effective pain relief in the perioperative period. Non-opioid analgesics promoted an optimal analgesic effect, did not cause residual sedation, anxiety, depressive effects and cognitive impairments, which showed their obvious advantage over opioids. Opioid-sparing effect was 96.3% (p < 0.05). Reducing the consumption of narcotic analgesics without worsening the quality of postoperative analgesia and the patient's well-being is an important advantage which allows minimizing the negative effects of opioids, facilitating the early rehabilitation of patients. Conclusions: Non-opioid analgesics can significantly limit endocrine and metabolic changes without worsening the quality of analgesia in the perioperative period.
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Tikuišis, Renatas, Povilas Miliauskas, Narimantas Evaldas Samalavičius, and Giedrė Rudinskaitė. "Epidurinės nejautros poveikis skausmo malšinimui ir žarnyno funkcijos atsitaisymui po gaubtinės ir tiesiosios žarnos rezekcijos." Lietuvos chirurgija 6, no. 3 (January 1, 2008): 0. http://dx.doi.org/10.15388/lietchirur.2008.3.2152.

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Renatas Tikuišis, Povilas Miliauskas, Narimantas Evaldas Samalavičius, Giedrė RudinskaitėVilniaus universiteto Onkologijos institutas, Santariškių g. 1, LT-08660 VilniusEl paštas: renatas.tikuisis@loc.lt Įvadas / tikslas Palyginti su sistemine analgezija opiatais, atliekant atviras gaubtinės ir tiesiosios žarnos operacijas, epidurinė nejautra efektyviau malšina skausmą ir ją sukėlus sumažėja pooperacinio žarnų nepraeinamumo dažnis. Šio tyrimo tikslas – nustatyti epidurinės analgezijos poveikį skausmo malšinimui ir žarnyno funkcijos atsitaisymui po gaubtinės ir tiesiosios žarnos operacijų. Ligoniai ir metodai Tyrime dalyvavo 50 ligonių, kuriems buvo atlikta gaubtinės arba tiesiosios žarnos rezekcija. Tai buvo perspektyvusis tyrimas, kuris truko dvejus metus. Atsitiktinės atrankos būdu ligoniai buvo suskirstyti į tiriamąją (T) ir kontrolinę (K) grupes. Po 25 ligonius pateko į kiekvieną grupę. T grupės ligoniams buvo taikyta epidurinė nejautra, o K grupės – švirkščiami narkotiniai analgetikai į veną ir penkis raumenis. Buvo vertinamas narkotinių analgetikų suvartojimas, skausmo intensyvumas po operacijos, žarnyno funkcijos atsitaisymo laikas ir laikas, kai ligonis pradėjo vartoti kietą maistą. Rezultatai Abi grupės pagal operacijos apimtį ir ligonių charakteristiką buvo labai panašios. T grupės ligoniams reikėjo mažiau narkotinių analgetikų, jiems skausmo intensyvumas buvo mažesnis, jų žarnyno veikla atsitaisė anksčiau ir jie anksčiau pradėjo vartoti kietą maistą, palyginti su K grupės ligoniais. Išvada Epidurinės analgezijos metodas yra pranašesnis už intraveninį skausmo malšinimo metodą, taip pat mažiau suvartojama narkotinių analgetikų. Epidurinė analgezija pagreitina žarnyno funkcijos atsitaisymą, todėl ligoniai anksčiau pradeda valgyti kietą maistą po atvirų gaubtinės ir tiesiosios žarnos operacijų. Reikšminiai žodžiai: epidurinė analgezija, intraveninė analgezija, gaubtinės žarnos rezekcija, tiesiosios žarnos rezekcija Influence of epidural analgesia on postoperative pain relief and gastrointestinal recovery after colorectal resection Renatas Tikuišis, Povilas Miliauskas, Narimantas Evaldas Samalavičius, Giedrė RudinskaitėVilnius University, Institute of Oncology, Santariškių str. 1, LT-08660 Vilnius, LithuaniaE-mail: renatas.tikuisis@gmail.com Backgound / objective Epidural analgesia provides superior analgesia with a lower incidence of postoperative ileus as compared with systemic opiate analgesia in open colorectal surgery. The aim of this study was to determine the effects of epidural analgesia on the outcome after colorectal surgery. Patients and methods Fifty patients were enrolled in this investigation. Open colorectal resection was performed for all these patients. The patients were randomly assigned into two groups: the study group (T) and the control group (K). Epidural analgesia was used for 25 patients of group T, and intravenous-intramuscular analgesia was used for 25 patients of group K. Consumption of narcotic analgesics, pain intensity, gastrointestinal recovery time and solid food tolerated time were investigated. Results There were no significant differences in the type of operations and preoperative patients’ characteristics between the groups. Consumption of narcotic analgesics was lower in group T, and analgesia was more effective in the epidural group. The mean time of peristalsis and solid food tolerance was earlier in group T as compared with group K. Conclusion Epidural analgesia provides a significant benefit as regards analgesic consumption, postoperative pain relief and the recovery of gastrointestinal function in patients undergoing open colorectal resection. Keywords: epidural analgesia, intravenous analgesia, colorectal surgery
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Stillman, Mark W., and Alexandra L. Whittaker. "Use and Efficacy of Analgesic Agents in Sheep (Ovis aries) Used in Biomedical Research." Journal of the American Association for Laboratory Animal Science 58, no. 6 (November 1, 2019): 755–66. http://dx.doi.org/10.30802/aalas-jaalas-19-000036.

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Sheep (Ovis aries) are widely used as large animal models in biomedical research. However, current literature on the use of analgesics in sheep generally focuses on an industry or farm level of use. This structured review evaluates use and efficacy of analgesics administered to sheep in a biomedical research setting. Electronic databases were searched with terms related to analgesia in research sheep. After application of exclusion criteria, 29 peer-reviewed publications were evaluated from 1995 to 2018. Drugs used for analgesia in sheep include opioids, α2 agonists, NSAID, local anesthetics, NMDA receptor antagonists, and calcium channel blockers. Opioid agonists have previously been considered short acting and of questionable efficacy in sheep, but newer modalities may provide effective analgesia. NSAID may exhibit an analgesic effect only when inflammatory pain is present and may not be beneficial for use in acute pain models. α2 agonists provide effective yet short-lived analgesia; however, side effects are of concern. Local anesthetics were previously widely used as stand-alone agents, as alternatives to the use of general anesthetics in sheep. These agents have since fallen out of favor as sole agents. Despite this, they provide a valuable analgesic effect when used as adjuncts to general anesthetic regimes. The NMDA antagonist ketamine provided good analgesia and is likely underutilized as an analgesic agent in sheep. Future controlled studies should further evaluate the analgesic properties of ketamine in sheep.
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Arendt-Neilsen, L., P. Bjerring, and J. Nielsen. "Regional variations in analgesic efficacy of EMLA cream. Quantitatively evaluated by argon laser stimulation." Acta Dermato-Venereologica 70, no. 4 (July 1, 1990): 314–18. http://dx.doi.org/10.2340/0001555570314318.

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The effect of EMLA cream (a eutectic mixture of local analgesics) applied for 30, 60, 90 and 120 min on the forehead, cheek, back, cubital fossa, and dorsum of the hand was studied. Analgesic onset, efficacy and duration were evaluated by sensory and pain thresholds to laser stimulation measured before, and 5, 60, 120, and 180 min after the cream was removed from the skin. Cutaneous blood flow was measured and found to be 4-5 times as high on the face as on the other locations. On the forehead the analgesic efficacy decreased with increased application time. For all other locations, efficacy increased with increasing application time. On the back, onset was rapid and sufficient analgesia could be obtained, but analgesias began to wane immediately after removal of the cream. In the cubital fossa and on the hand, onset was tardy, and efficacy continued to increase for 60 min after cream removal, followed by a slow decline. Blood flow, epidermal and dermal thickness are important factors affecting onset, efficacy and duration of EMLA analgesia.
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Dissertations / Theses on the topic "Analgesia"

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Ledin, Eriksson Susanne. "Central-block techniques for relief of labour pain /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-911-0/.

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Camacho, Meneses Martha, and de la Cruz Patricia Mello. "Dolor postoperatorio: analgesia preventiva versus analgesia postoperatoria con ketorolaco en colecistectomía videolaparoscópica." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2002. https://hdl.handle.net/20.500.12672/2061.

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Objetivo: Determinar si la Analgesia Preventiva es mejor que la Analgesia Postoperatoria, usando Ketorolaco. Pacientes y Método: Estudio prospectivo de 60 pacientes, sometidos a Colecistectomía Laparoscopica electiva; divididos en dos grupos: 1)ketorolaco preventivo 2)Ketorolaco postoperatorio. La Inducción fue con Fentanilo 2 ugr/Kg, Rocuronio 0.6 mg/kg y Tiopental 6mg/kg. Durante la colocación de los campos operatorios se administró Ketorolaco 60mg EV, en el grupo 1. En el mantenimiento: Sevorane, Fentanilo 50 ugr cada 30 minutos y Rocuronio 10mg cada 35 min. Se controló las funciones vitales y saturación arterial. Para el grupo 2 se administró Ketorolaco EV 60 mg terminada la cirugía y antes de la extubación. La dosis de rescate fue con Metamizol 2gr EV. Se usó la Escala Análoga Visual para la valoración del dolor; ambos grupos se compararon con el método estadístico MANOVAr, considerando un nivel de significancia de 5%. Resultados: El EVA promedio postoperatorio fue 2 para el grupo 1 y 5 para el grupo 2, después de 24 horas fue 3 y 4 respectivamente (p menor a 0.05). Los efectos adversos, fueron 5/30 (17%) en el Grupo 1:sangrado, y 3/30 (10%) en el Grupo 2: 1 con urticaria y 2 con nauseas (p mayor a 0.05). La dosis de rescate fue necesaria en 7% de los pacientes en el Grupo 1 y 53% en el Grupo 2 (p menor a 0.001). Conclusión: La Analgesia Preventiva es superior a la Analgesia postoperatoria, con Ketorolaco, disminuyendo los requerimientos de analgésicos de rescate.
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Lorena, Sílvia Elaine Rodolfo de Sá [UNESP]. "Estudo demográfico sobre as condutas de avaliação e tratamento da dor dos médicos veterinários brasileiros no período perioperatório de grandes e pequenos animais." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/101036.

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Made available in DSpace on 2014-06-11T19:31:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-26Bitstream added on 2014-06-13T21:02:11Z : No. of bitstreams: 1 lorena_sers_dr_botfmvz.pdf: 632999 bytes, checksum: 35174e377fd65ef6483f2f8509b96974 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O uso de analgésicos em animais é justificado moral e cientificamente. Para tal, é necessário que os profissionais saibam reconhecer e tratar a dor de forma adequada em animais. Objetivou-se correlacionar diversos dados demográficos para obter o perfil do médico veterinário brasileiro de grandes e pequenos animais. O questionário da pesquisa foi composto por: dados pessoais, utilização de fármacos analgésicos, analgesia, conduta no alívio da dor, uso de analgésicos em diversos procedimentos de grandes e pequenos animais, avaliação da dor e atualizações. A estatística foi realizada pelo programa SAS for Windows versão 9.1.3 com estatística descritiva com análise de frequência. Para as comparações simples foi utilizado o teste de qui-quadrado (x2). Foram obtidos 1.298 questionários de pequenos animais e 713 de grandes. Mulheres e profissionais graduados havia menos de dez anos conferiram maiores escores de dor que homens e profissionais formados havia mais de dez anos, porém a duração do tratamento não diferiu entre os gêneros. Os opioides mais utilizados para a analgesia foram tramadol (79%) e morfina (50,5%), em cães e gatos, e butorfanol (43,4%) e tramadol (39%) em grandes animais. Os efeitos adversos mais reportados dos opioides em gatos foram depressão respiratória e excitação. Em cães os principais efeitos adversos assinalados foram depressão respiratória e êmese. Para grandes animais, as preocupações com o uso desses fármacos foram: risco de excitação e síndrome cólica equina. Mais de 50% dos veterinários não utilizava opioides em bovinos. Os anti-inflamatórios não esteroidais (AINEs) mais escolhidos para pequenos animais foram meloxicam (81%) e cetoprofeno (70,4%), e flunixin meglumine (83,2%) e cetoprofeno (67,6%) em grandes animais. Os efeitos...
The use of analgesics in animals is morally and scientifically justified. According to that, the professionals should know how to recognize and treat pain in animals. The aim of this study was to correlate the demographic data of the Brazilian veterinarians, with the use of analgesics, the factors that affected the decision on the use of analgesia, attitudes, knowledge and methods of obtaining information on the evaluation and treatment of pain in animals. The questionnaire was composed of demographics, personal data, use of analgesics in general and specific procedures, analgesia, attitudes in the assessment and relief of pain and types of information in the area. The descriptive statistics with frequency analysis was performed using SAS for Windows 9.1.3. Chi-square (x2) for simple comparisons test was used. Questionnaires were obtained from 1298 small and 713 large animal veterinarians. Women and veterinarians graduated for less than ten years attributed higher pain scores than men, and veterinarians graduated for over ten years, but the frequency and duration of analgesic treatment did not differ between gender. The most commonly used opioid for analgesia of small animals were tramadol (79%) and morphine (50.5%) for dogs and cats, and butorphanol (43.4%) and tramadol (39%) for large animals. The most important side effects of opioids in small animals were respiratory depression and excitement, for cats and emesis in dogs and excitement and colic syndrome in 4 horses. NSAIDs of choice for small animals were meloxicam (81%) and ketoprofen (70.4%) and for large animals, flunixin meglumine (83.2%) and ketoprofen (67.6%). Side effects of NSAIDs most frequently reported for all species were gastric changes and nephrotoxicity. The most important limiting factors for the use of NSAIDs and opiods were the side effects for horses and the cost for cattles. The cats received lower pain... (Complete abstract click electronic access below)
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Brooks, Jason Whitworth. "Aspects of cannabinoid analgesia." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408407.

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Bortolami, Elisa. "Advances in sheep analgesia." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424188.

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Sheep (Ovis aries) are widely used in experimental settings and breeding system, nevertheless pain treatment in this species seems to be overlooked. The first two studies described in this thesis were designed to evaluate administration of analgesics both in the experimental and clinical setting. The third study evaluated the pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol (M1) in sheep in a preclinical model of pain. The first study consisted of a meta-analysis of the reported use of analgesics in sheep for experimental purposes. Studies involving experimental procedures in sheep carried out in selected years (2008-2011-2014) were identified using a search engine. A total of 75 papers were selected. The study showed that analgesic treatment was often not accurately reported. The second study consisted of an on-line questionnaire evaluating the current attitudes of Italian practitioners to assessment and treatment of pain in sheep. The questionnaire consisted of five sections regarding the demographic data, analgesic drugs and techniques used to treat pain, attitudes to pain relief and assessment of pain and the knowledge on the topic of sheep analgesia. Only a modest number of questionnaires were returned. The most commonly used drugs by sheep practitioners who replied to the questionnaire were non steroidal anti-inflammatory drugs and local anaesthetics. In the practitioners’ opinion the main reasons for analgesic drugs not to be administered to sheep was the lack of licensed drugs followed by costs, withholding times and regulations. The vast majority of practitioners were interested in improving their knowlwdge on sheep analgesia. The third study investigated the pharmacokinetic profile and antinociceptive effect of tramadol and M1 following intravenous administration in sheep. Six healthy adult sheep were administered 4 (T4) and 6 (T6) mg/kg of tramadol (T) and saline (SAL) over 2 minutes in a cross over design with a two weeks wash out period. At predetermined time points blood samples were collected, physiological parameters and mechanical nociceptive threshold (NMT) values were recorded. Tramadol and M1 fitted a two compartmental model and a non compartmental model respectively. Pharmacokinetic parameters were similar for T4 and T6. Tramadol and M1 plasma concentrations decreased rapidly. Physiological parameters were not statistically different between groups. No mechanical antinociceptive effects of tramadol were detected, as MNT values did not statistically differ between groups. In conclusion, these studies showed that there is great scope for improvement in pain assessment and treatment in sheep both in the research than clinical settings. Moreover more experimental and clinical studies regarding the pharmacokinetic and pharmacokinamic effects of analgesic drugs in sheep are advocated in order to improve their welfare.
La pecora domestica (Ovis aries) è una delle specie animali più comunemente allevate ed utilizzate nella ricerca biomedica; nonostante questo l’analgesia in questo animale è stata a lungo trascurata. I primi due studi presentati in questa tesi sono stati elaborati allo scopo di valutare la somministrazione di analgesici nell’ambito clinico e sperimentale. Il terzo studio valuta la farmacocinetica e gli effetti antinocicettivi del tramadolo e del suo metabolita O desmethyltramadol (M1). Il primo studio consiste in una meta-analisi sull’ uso di farmaci analgesici riportato nelle pecore utilizzate a fini sperimentali. Studi riguardanti procedure sperimentali in pecore effettuati in anni selezionati (2008-2011-2014) sono stati identificati utilizzando un motore di ricerca. In totale, sono stati selezionati 75 articoli scientifici. Lo studio evidenzia mostra che la terapia antalgica spesso non viene accuratamente riportata. Il secondo studio consiste in un questionario on line redatto allo scopo di valutare l’attuale approccio dei veterinari italiani, che si occupano della specie ovina, alla valutazione ed al trattamento del dolore in questa specie. Il questionario era diviso in cinque sezioni riguardanti i dati demografici, l’uso di farmaci analgesici a tecniche utilizzate per apportare analgesia, e l’approccio utilizzato dai veterinari nella valutazione e trattamento del dolore nella specie ovina, ed, infine, la loro conoscenza riguardo tale argomento. Un numero limitato di veterinari ha completato il questionario. I farmaci più comunemente utilizzati dai veterinari che hanno risposto al questionario sono i farmaci antiinfiammatori non steroidei e gli anestetici locali. Secondo l’opinione dei veterinari, le ragioni principali per cui la terapia analgesica non viene effettuata nella specie ovina erano la mancanza di farmaci registrati, il loro costo, i tempi di sospensione e la regolamentazione riguardante il loro utilizzo. La maggior parte dei veterinari si dimostrava interessata a migliorare le proprie conoscenze riguardo l’analgesia nella specie ovina. Il terzo studio investiga la farmacocinetica e gli effetti antinocicettivi del tramadolo ed M1 dopo somministrazione endovenosa nelle pecore. Due dosi di tramadolo, 4 mg/kg (T4) e 6 mg/kg (T6), e soluzione salina (SAL) sono state somministrate in due minuti a sei pecore adulte e sane in uno studio randomizzato “in cieco” con un periodo di sospensione di due settimane. A tempi predeterminati, sono stati effettuati i prelievi di sangue per l’analisi farmacocinetica, e sono stati registrati i parametri fisiologici e i valori dopo stimolazione nocicettiva meccanica (MNT). Tramadolo ed M1 presentano rispettivamente una cinetica bi-compartimentale e non-compartimentale. I parametri farmacocinetici sono simili per le due dosi T4 e T6. Le concentrazioni plasmatiche di tramadolo ed M1 sono rapidamente diminuite. I parametri fisiologici non sono risultati statisticamente diversi tra i gruppi. Non sono stati evidenziati effetti antinociettivi del tramadolo; infatti i valori di MNT non sono risultati statisticamente diversi tra i gruppi. Concludendo, questi studi hanno dimostrato che ci sono ampi margini di miglioramento nella valutazione e trattamento del dolore nella specie ovina sia in ambito sperimentale sia clinico. Inoltre, sono necessari studi sperimentali e clinici riguardanti la farmacocinetica e farmacodinamica di farmaci analgesici nella specie ovina al fine di migliorarne il benessere.
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Moreira, Alcides. "Analgesia preemptiva versus analgesia preventiva com lumiracoxibe em cirurgias de terceiros molares retidos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290774.

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Orientador: Eduardo Dias de Andrade
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-15T10:59:54Z (GMT). No. of bitstreams: 1 Moreira_Alcides_D.pdf: 1121532 bytes, checksum: c92e82c008dbefd9aa2585b01ab95d3f (MD5) Previous issue date: 2010
Resumo: A analgesia preemptiva consiste na instituição de um regime analgésico previamente ao estímulo nociceptivo, com o objetivo de prevenir a hiperalgesia e a subsequente amplificação da dor. O objetivo deste trabalho foi avaliar a analgesia preemptiva com o lumiracoxibe, inibidor seletivo da cicloxigenase-2 (COX-2), em exodontias bilaterais de terceiros molares mandibulares retidos, comparando-a à analgesia preventiva. Foram selecionados 16 voluntários com bom estado de saúde geral, com indicação para a remoção dos dois terceiros molares mandibulares retidos, em posições simétricas e assintomáticos. O estudo foi delineado de forma duplo-cego e cruzado. Em uma das cirurgias os voluntários foram tratados com lumiracoxibe 400 mg, via oral, em dose única, administrada uma hora antes da cirurgia, seguido da administração de placebo, logo após o término do procedimento. Na cirurgia contralateral, de modo inverso, o tratamento consistiu do uso do placebo antes da intervenção, seguido da administração de lumiracoxibe 400 mg após o término do ato cirúrgico. A eficácia dos regimes analgésicos foi avaliada pelos seguintes parâmetros: tempo decorrido para a tomada do primeiro comprimido de analgésico a partir do final da intervenção; quantidade de comprimidos de analgésico tomada nas primeiras 24 h do pósoperatório; escala visual analógica nos tempos de 4, 8, 12 e 24 h e qualidade do tratamento. Não houve diferenças estatisticamente significantes entre os tratamentos preemptivo e preventivo no que se refere ao tempo requerido para a tomada da primeira dose de analgésico: 241,5 (±322,5) e 137,2 (± 246,48) minutos (p=0,3633); quantidade de comprimidos analgésicos tomados no período pósoperatório: 2,6 (±2,56) e 4,2 (± 5,13) comprimidos (p=0,5471), qualidade do tratamento (p=0,6794) e escala visual analógica (p=0,3916). Concluiu-se que o tratamento com lumiracoxibe, prévio ao estímulo nociceptivo (analgesia preemptiva) ou posterior a ele (analgesia preventiva), promove efeito analgésico efetivo e similar em cirurgias de terceiros molares mandibulares retidos.
Abstract: Preemptive analgesia is defined as an analgesic regimen established before the occurrence of noxious stimulus in order to prevent hyperalgesia and subsequent amplification of pain. The aim of this study was to evaluate the preemptive analgesia with lumiracoxib, a selective cicloxigenase-2 (COX-2) inhibitor, in impacted third molars surgery, compared to the protocol of preventive analgesia. Sixteen subjects who required elective surgical removal of symmetric and asymptomatic impacted mandibular third molars, in an outpatient setting were selected for the study, characterized as double-blind and crossover. In one of the surgeries, the volunteers where treated with lumiracoxib 400 mg orally in a single dose given one hour before surgery, followed by administration of placebo, immediately after the end of the procedure. Conversely, in contralateral surgery, treatment consisted of using placebo before intervention, followed by administration of lumiracoxib 400 mg after surgery. The effectiveness of analgesia was evaluated by the following parameters: time elapsed from the end of the intervention, until the first analgesic intake in the postoperative period; number of analgesic tablets consumed in the first 24 hours after surgery; visual analog scale (VAS) at of 4, 8, 12 and 24 h after the surgery and treatment quality. There were o statistically significant differences between preemptive and preventive treatments in relation to the time required for the first analgesic intake: 241.5 (± 322.5) and 137.2 (± 246.48) minutes (p = 0.3633), number of analgesic tablets taken in the postoperative period: 2.6 (± 2.56) and 4.2 (± 5.13) tablets (p = 0.5471), quality of treatment (p = 0.6794) and visual analog scale (p = 0.3916). It was concluded that treatment with lumiracoxib, prior to noxious stimulation (preemptive analgesia) or after it (preventive analgesia), promotes similar analgesic effect in lower impacted third molars surgery.
Doutorado
Farmacologia, Anestesiologia e Terapeutica
Doutor em Odontologia
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Swanton, Rosie. "Learned analgesic cue association and placebo analgesia in rats: an empirical assessment of an animal model and meta-analysis." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24505.

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This thesis focuses on animal models of placebo analgesia. Placebo analgesia is the experience of reduced pain, or pain relief, without the delivery of a pain-relieving drug or actual reduction of the painful stimulus. Research into the underlying neuro-mechanisms of placebo analgesia have been limited by unreliable animal models of the effect and attempts to replicate human placebo testing paradigms in animals have had mixed outcomes. In many cases, a tolerance to analgesic has been observed instead. The project had two main aims. The first was to replicate a recent model of placebo analgesia. The second aim of the project was to conduct a meta-analysis of the existing published literature and determine the overall effect size of placebo analgesia in rodent models. Experiment 1 sought to replicate a previous model of rodent placebo analgesia. Results from experiment 1 did not support previous findings and showed no evidence for placebo analgesia in rodents. Experiment 2 was a second attempt to replicate a previous model of placebo analgesia. The second attempt adjusted the potential limitations from experiment 1 such as cue chamber intensity and re-ran the protocol using rodents of the same sex and strain as the original paper. Results from experiment 2 were similar to experiment 1 and did not support the hypotheses or provide any evidence for placebo analgesia in rodents. Experiment 3 used a simplified version of the behavioural conditioning methodology from experiments 1 and 2, but was modified to reduce handling stress, to increase the salience of the to-be-conditioned placebo cue, and to reduce stress-induced analgesia. Results from experiment 3 found no evidence for placebo analgesia in rodents was observed. The results from 45 studies across 21 papers were meta-analysed and showed a moderate effect size for placebo analgesia in rodents, and moderator analysis revealed that cue type was a significant factor in the development of the effect in rodents. Using a context cue box as the cue type was found to be the most effective approach to establishing placebo analgesia in rodents. The current research has highlighted the replicability problem in pre-clinical research and as such it is recommended that animal studies looking at placebo analgesia aim to include more methodological detail in their reporting, particularly in regard to cue type. A limitation of the current project was the exclusion of drug tolerance literature that results in nocebo responses. Future research should compare and contrast this body of work more closely with research into placebo analgesia in rodents.
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Yat, P. N. "Synthesis and reactions of 2,6-methano-3-benzazocines and arylbicyclo[4.n.1]enones as potential analgesics." Thesis, University of Salford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376863.

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Volmanen, P. (Petri). "Intravenous patient controlled analgesia with remifentanil in early labour." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514261176.

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Abstract In four prospective clinical trials, 114 parturients used intravenous patient-controlled remifentanil analgesia during the 1st stage of labour. The median effective dose per bolus was ascertained to be 0.4 μg/kg and the pain scores were reduced with this by a median of 2 on a numerical scale (0–10). Compared with nitrous oxide, 15 parturients included in a cross-over study reported a larger reduction in pain scores during remifentanil analgesia (1.5 vs. 0.5, p =  0.001) and better pain relief scores (2.5 vs. 0.5 on a ranked five point scale 0–4, p  <  0.001). In a parallel study including 45 parturients, epidural analgesia (EDA, 20 ml bupivacaine 0.625 mg/ml and fentanyl 2 μg/ml) was associated with lower pain scores (5.2 vs. 7.3 with remifentanil, p =  0.004) but variables related to satisfaction with analgesia (pain relief score, proportion of mothers with desire to continue with the given medication and termination of the study due to inadequate pain relief) were similar. A comparison of two methods for timing the remifentanil bolus during the uterine contraction cycle suggested that delaying the bolus does not improve analgesia. A period effect was noted in the cross-over trial with higher pain scores and increased drug consumption during the second study period suggesting acute hyperalgesia. Side effects of remifentanil analgesia included respiratory depression warranting oxygen supplementation in 33% of parturients. Sedation was experienced by the parturients using remifentanil and this was scored as stronger than sedation during nitrous oxide and EDA. The number of parturients with nausea did not increase during remifentanil analgesia. Other maternal side effects included dizziness, a difficulty in visual focusing and itching. Foetal heart rate tracing abnormalities were noted. The incidence of abnormal tracings and decreased UapH were not different, however, from that observed during nitrous oxide or EDA. Apgar scores at 1 and 5 minute indicated no neonatal depression.
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Marsh, Deborah Frances. "The ontogeny of opioid analgesia." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286332.

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Books on the topic "Analgesia"

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Sinatra, Raymond S., Jonathan S. Jahr, and J. Michael Watkins-Pitchford, eds. The Essence of Analgesia and Analgesics. Cambridge: Cambridge University Press, 2009. http://dx.doi.org/10.1017/cbo9780511841378.

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Stein, Christoph, ed. Analgesia. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-33823-9.

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Szallasi, Arpad, ed. Analgesia. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-323-7.

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Burns, Bill. Analgesia. Montréal: Galerie Rochefort, 1993.

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Tamerius, Rita. Effective pain management. 5th ed. La Mesa, CA: Western Schools Press, 1994.

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Capogna, Giorgio, ed. Epidural Labor Analgesia. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13890-9.

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Thomas, Stephen H., ed. Emergency Department Analgesia. Cambridge: Cambridge University Press, 2008. http://dx.doi.org/10.1017/cbo9780511544835.

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De Castro, J., J. Meynadier, and M. Zenz. Regional Opioid Analgesia. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-009-2321-8.

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Watson, Donna. Conscious sedation/analgesia. St. Louis: Mosby, 1998.

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D, Kelly Dennis, and New York Academy of Sciences., eds. Stress-induced analgesia. New York, N.Y: New York Academy of Sciences, 1986.

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Book chapters on the topic "Analgesia"

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Hilton, Michael T., and Paul M. Paris. "Analgesia." In Emergency Medical Services, 470–76. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118990810.ch67.

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Livingston, Alex, and Deborah V. Wilson. "Analgesia." In Manual of Equine Anesthesia and Analgesia, 293–304. Oxford, UK: Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470753248.ch20.

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Deschner, Martin. "Analgesia." In Encyclopedia of Behavioral Medicine, 103–4. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1326.

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Abrams, David B., J. Rick Turner, Linda C. Baumann, Alyssa Karel, Susan E. Collins, Katie Witkiewitz, Terry Fulmer, et al. "Analgesia." In Encyclopedia of Behavioral Medicine, 85–86. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1326.

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Whiteside, Douglas P. "Analgesia." In Zoo Animal and Wildlife Immobilization and Anesthesia, 83–108. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118792919.ch6.

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Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, Marc N. Potenza, Tayfun Uzbay, Lisiane Bizarro, David C. S. Roberts, et al. "Analgesia." In Encyclopedia of Psychopharmacology, 79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1044.

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Driessen, Bernd, and Laura Zarucco. "Analgesia." In Equine Laminitis, 291–305. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119169239.ch33.

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Champion, Howard R., Nova L. Panebianco, Jan J. De Waele, Lewis J. Kaplan, Manu L. N. G. Malbrain, Annie L. Slaughter, Walter L. Biffl, et al. "Analgesia." In Encyclopedia of Intensive Care Medicine, 166. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1116.

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Santos, Luiz C., and Louise L. Southwood. "Analgesia." In Practical Guide to Equine Colic, 51–61. West Sussex, UK: John Wiley & Sons, Inc,., 2013. http://dx.doi.org/10.1002/9781118704783.ch6.

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Fujimori, M. "Systemic Analgesia in Obstetrics: Inhalation Analgesia." In Gynecology and Obstetrics, 286–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70559-5_95.

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Conference papers on the topic "Analgesia"

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Неймарк, Михаил Израилевич, Сергей Владимирович Жилин, and Роман Владимирович Киселев. "ВЛИЯНИЕ БЕЗОПИОИДНОЙ АНАЛЬГЕЗИИ НА ТЕЧЕНИЕ ПОСЛЕОПЕРАЦИОННОГО ПЕРИОДА." In Наука, общество, производство и промышленность: актуальные проблемы и перспективы: сборник статей международной научной конференции (Омск, Апрель 2023). Crossref, 2023. http://dx.doi.org/10.37539/230407.2023.66.44.007.

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Проведено рандомизированное исследование больных перенесших рукавную резекцию желудка. В первой группе использовали безопиоидную мультимодальную аналгезию, а во второй группе для обезболивания использовали опиоидные анальгетики. A randomized study of patients who underwent sleeve resection of the stomach was conducted. In the first group, non-opioid multimodal analgesia was used, and in the second group, opioid analgesics were used for anesthesia.
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Hunt, Clive, Paul Turner, and Amy Pharaoh. "101 Timely administration of analgesia." In The APM’s Annual Supportive and Palliative Care Conference, In association with the Palliative Care Congress, “Towards evidence based compassionate care”, Bournemouth International Centre, 15–16 March 2018. British Medical Journal Publishing Group, 2018. http://dx.doi.org/10.1136/bmjspcare-2018-aspabstracts.128.

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Fujimura, N., K. Nobukuni, T. Obuchi, and J. Yoshino. "Comparison of Three Analgesic Methods on Postoperative Analgesia in Patients Undergoing Video-Assisted Thoracic Surgery." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3586.

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Nielsen, T. H., H. K. Nielsen, S. E. Husted, S. L. Hansen, and K. H. Olsen. "PLATELET FUNCTION AND ENDOCRINE STRESS RESPONSE DURING BUPIVACAINE EPIDURAL ANALGESIA. THE EFFECT OF MORPHINE ADDITION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644887.

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Platelet aggregation plays a central role in thromboembolism. Epidural analgesia can diminish the formation of deep venous thrombosis. In a randomized study twenty patients admitted to transartliroscopic meniscectomy were allocated to epidural analgesia with or without morphine epidurally. S-cortisol, s-thromboxane -B2(s-T2 B2) and platelet aggregation were measured before premedication, when epidural block extended from S3to T5, just before skin closure and exsufflation of tne thigh tourniquet, and the last sample was taken ten min after exsufflation. Aggregability was measured in platelet-rich plasma and expressed as the treshold concentration of collagen. Cortisol and T Bp were measured by RIA.S-cortisol decreased duringxanalgesia in the morphine group (p<o.o5), and during operation in both groups (p<o.o5) being significant lower in the morphine group (p<o.o5).S-TxB2 decreased significantly in the morphine group during analgesia, but there was no significant difference in s-TxB2 between the two groups. Treshold concentration of Collagen for aggregation of platelets showed an insignificant increase for both groups during analgesia, but did not differ between the two groups. Removal of the tourniquet did not influence any of the measurements. It is concluded that additionof morphine to bupivaca- ine epidural analgesia further decrease activity of the adrenocortical system, and the combined regime seems to inhibit platelet function in the same manner as monotherapy with local anaesthetics.
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XU, Qiu-ling, and Tao LIU. "The Neural Mechanism of Acupuncture Analgesia." In 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/bbe-17.2017.7.

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"ANALGESIA NO PARTO NORMAL: REVISÃO INTEGRATIVA." In ANAIS DO II CONGRESSO BRASILEIRO EM SAÚDE DA MULHER. EDITORA SCISAUDE, 2023. http://dx.doi.org/10.56161/sci.ed.2023080938.

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De jonckheere, J., M. Delecroix, M. Jeanne, A. Keribedj, N. Couturier, and R. Logier. "Automated analgesic drugs delivery guided by vagal tone evaluation: Interest of the Analgesia Nociception Index (ANI)." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609910.

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Theerth, K., S. Kamath, M. Reddy, and D. Chakrabarti. "Evaluation of analgesia nociception index as a tool to monitor pain and manage analgesia during supratentorial craniotomies." In 18th Annual Conference of Indian Society of Neuroanaesthesiology and Critical Care (ISNACC 2017). Thieme Medical and Scientific Publishers Private Ltd., 2017. http://dx.doi.org/10.1055/s-0038-1646258.

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Czub, Marcin, and Joanna Piskorz. "How Body Movement Influences Virtual Reality Analgesia?" In 2014 International Conference on Interactive Technologies and Games (iTAG). IEEE, 2014. http://dx.doi.org/10.1109/itag.2014.8.

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Araújo Rodrigues, Arnaldo, Maria Letícia Lopes de Freitas, Débora Veloso, and Luana Dias de Moura. "Analgesia: controle da dor na medicina veterinária." In ANAIS DO 1° CONGRESSO INTERNACIONAL CIêNCIA E SOCIEDADE. Galoa, 2023. http://dx.doi.org/10.17648/cics-2023-177940.

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Reports on the topic "Analgesia"

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Figliola, Mary C. Peripheral Opioid Analgesia. Fort Belvoir, VA: Defense Technical Information Center, June 1999. http://dx.doi.org/10.21236/ad1012136.

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Karna, Shravya, and Alex Konstantatos. Methadone and Buprenorphine for Management of Acute Postoperative Pain. World Federation of Societies of Anaesthesiologists, May 2022. http://dx.doi.org/10.28923/atotw.472.

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Methadone and buprenorphine have shown to decrease total opioid requirements and attenuate side effects post operatively. Methadone’s pharmacokinetics properties make it a potent analgesic whilst sublingual and transdermal buprenorphine is an excellent step-down to parenteral analgesia.
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Lu, Xingang, and Wei Lu. Analgesia effect of TENS on myofascial pain syndrome. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0090.

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Lumpkin, Shamsie, Isaac Parrish, Austin Terrell, and Dwayne Accardo. Pain Control: Opioid vs. Nonopioid Analgesia During the Immediate Postoperative Period. University of Tennessee Health Science Center, July 2021. http://dx.doi.org/10.21007/con.dnp.2021.0008.

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Background Opioid analgesia has become the mainstay for acute pain management in the postoperative setting. However, the use of opioid medications comes with significant risks and side effects. Due to increasing numbers of prescriptions to those with chronic pain, opioid medications have become more expensive while becoming less effective due to the buildup of patient tolerance. The idea of opioid-free analgesic techniques has rarely been breached in many hospitals. Emerging research has shown that opioid-sparing approaches have resulted in lower reported pain scores across the board, as well as significant cost reductions to hospitals and insurance agencies. In addition to providing adequate pain relief, the predicted cost burden of an opioid-free or opioid-sparing approach is significantly less than traditional methods. Methods The following groups were considered in our inclusion criteria: those who speak the English language, all races and ethnicities, male or female, home medications, those who are at least 18 years of age and able to provide written informed consent, those undergoing inpatient or same-day surgical procedures. In addition, our scoping review includes the following exclusion criteria: those who are non-English speaking, those who are less than 18 years of age, those who are not undergoing surgical procedures while admitted, those who are unable to provide numeric pain score due to clinical status, those who are unable to provide written informed consent, and those who decline participation in the study. Data was extracted by one reviewer and verified by the remaining two group members. Extraction was divided as equally as possible among the 11 listed references. Discrepancies in data extraction were discussed between the article reviewer, project editor, and group leader. Results We identified nine primary sources addressing the use of ketamine as an alternative to opioid analgesia and post-operative pain control. Our findings indicate a positive correlation between perioperative ketamine administration and postoperative pain control. While this information provides insight on opioid-free analgesia, it also revealed the limited amount of research conducted in this area of practice. The strategies for several of the clinical trials limited ketamine administration to a small niche of patients. The included studies provided evidence for lower pain scores, reductions in opioid consumption, and better patient outcomes. Implications for Nursing Practice Based on the results of the studies’ randomized controlled trials and meta-analyses, the effects of ketamine are shown as an adequate analgesic alternative to opioids postoperatively. The cited resources showed that ketamine can be used as a sole agent, or combined effectively with reduced doses of opioids for multimodal therapy. There were noted limitations in some of the research articles. Not all of the cited studies were able to include definitive evidence of proper blinding techniques or randomization methods. Small sample sizes and the inclusion of specific patient populations identified within several of the studies can skew data in one direction or another; therefore, significant clinical results cannot be generalized to patient populations across the board.
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Sandeep, Bhushan, Huang Xin, and Xiao Zongwei. A comparison of regional anesthesia techniques in patients undergoing of video-assisted thoracic surgery: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0003.

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Review question / Objective: Although video-assisted thoracoscopic surgery is a minimally invasive surgical technique, the pain remains moderate to severe. We comprehensively compared the regional anesthesia methods for postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery. Eligibility criteria: All published full-article RCTs comparing the analgesic efficacy of investigated regional anesthesia technique or comparative blocks in adult patients undergoing any VATS were eligible for inclusion. There were no language restrictions. Moreover, we also excluded case reports, non-RCT studies, incomplete clinical trials, and any trials used multiple nerve blocks. We also excluded any conference abstracts which could not offer enough information about the study design, or by data request to the author.
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Tzvetkova, Mimoza, Zafer Sabit, Christina Vidinova, Roman Tashev, and Hristina Nocheva. Cannabinoid and Serotonergic Systems in Modulation of Stress induced Analgesia. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, April 2021. http://dx.doi.org/10.7546/crabs.2021.04.17.

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Zhang, Lulu, Buhuai Dong, Yanan Wei, Peng Liu, Yun Liang, and Shanshan Zhang. Acupoint acupuncture for postoperative analgesia after general anesthesia: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2021. http://dx.doi.org/10.37766/inplasy2021.4.0075.

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Rowbotham, Professor David, Dr Jeremy Cashman, Dr David Counsell, Ms Felicia Cox, Dr Paulah Crawford, Dr John Goddard, Dr Simon Higgs, et al. Best practice in the management of epidural analgesia in the hospital setting. The Association of Anaesthetists of Great Britain and Ireland, November 2010. http://dx.doi.org/10.21466/g.bpitmoe.2010.

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Yue, Lei, Guanzhang Mu, Zengmao Lin, and Haolin Sun. Impact of low-dose intrathecal morphine on orthopedic surgery: a protocol of a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0029.

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Review question / Objective: Patients undergoing orthopedic surgery usually suffer considerably from peri-operative pain and intrathecal morphine (ITM) has recent been used as an effective analgesia method. The intrathecal morphine dose achieving optimal analgesia for orthopedic surgery while minimizing side effects has not yet been determined. There is currently a lack of literature synthesis in the safety and effects of low-dose ITM on orthopedic surgery. Condition being studied: Low-dose intrathecal morphine on orthopedic surgery. Information sources: We will search the following electronic databases, registries and websites on January 11th 2022, unrestricted by date. Grey literature and non-English studies will not be excluded. English Databases: PubMed, Cochrane library and Web of science. Chinese database: Cnki.net Trial registries: ClinicalTrials.gov.
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tantri, aida rosita, Riyadh Firdaus, Hansen Angkasa, Ahmad Pasha Natanegara, and Muhammad A. I. Maulana. Pre-emptive versus Preventive Analgesia for Postoperative Pain: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2023. http://dx.doi.org/10.37766/inplasy2023.6.0005.

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