Academic literature on the topic 'Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI'
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Journal articles on the topic "Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI"
Provenzano, Francesca, Sophie Nyberg, Debora Giunti, Carola Torazza, Benedetta Parodi, Tiziana Bonifacino, Cesare Usai, et al. "Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS." Cells 11, no. 23 (December 4, 2022): 3923. http://dx.doi.org/10.3390/cells11233923.
Full textMcCluskey, Gavin, Karen E. Morrison, Colette Donaghy, Frederique Rene, William Duddy, and Stephanie Duguez. "Extracellular Vesicles in Amyotrophic Lateral Sclerosis." Life 13, no. 1 (December 31, 2022): 121. http://dx.doi.org/10.3390/life13010121.
Full textVassileff, Natasha, Lesley Cheng, and Andrew F. Hill. "Extracellular vesicles – propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases." Journal of Cell Science 133, no. 23 (December 1, 2020): jcs243139. http://dx.doi.org/10.1242/jcs.243139.
Full textBonafede, Roberta, Ermanna Turano, Ilaria Scambi, Alice Busato, Pietro Bontempi, Federica Virla, Lorenzo Schiaffino, Pasquina Marzola, Bruno Bonetti, and Raffaella Mariotti. "ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS." International Journal of Molecular Sciences 21, no. 10 (May 21, 2020): 3651. http://dx.doi.org/10.3390/ijms21103651.
Full textBonafede, Brandi, Manfredi, Scambi, Schiaffino, Merigo, Turano, et al. "The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis." Cells 8, no. 9 (September 14, 2019): 1087. http://dx.doi.org/10.3390/cells8091087.
Full textGiunti, Debora, Chiara Marini, Benedetta Parodi, Cesare Usai, Marco Milanese, Giambattista Bonanno, Nicole Kerlero de Rosbo, and Antonio Uccelli. "Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation." Scientific Reports 11, no. 1 (January 18, 2021). http://dx.doi.org/10.1038/s41598-021-81039-4.
Full textWang, Xichen, Yong Zhang, Tian Jin, Benson O. A. Botchway, Ruihua Fan, Lvxia Wang, and Xuehong Liu. "Adipose-Derived Mesenchymal Stem Cells Combined With Extracellular Vesicles May Improve Amyotrophic Lateral Sclerosis." Frontiers in Aging Neuroscience 14 (May 18, 2022). http://dx.doi.org/10.3389/fnagi.2022.830346.
Full textBelkozhayev, Ayaz M., Minnatallah Al-Yozbaki, Alex George, Raigul Ye Niyazova, Kamalidin O. Sharipov, Lee J. Byrne, and Cornelia M. Wilson. "Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration." Current Neuropharmacology 19 (August 17, 2021). http://dx.doi.org/10.2174/1570159x19666210817150141.
Full textSykova, Eva, Dasa Cizkova, and Sarka Kubinova. "Mesenchymal Stem Cells in Treatment of Spinal Cord Injury and Amyotrophic Lateral Sclerosis." Frontiers in Cell and Developmental Biology 9 (July 6, 2021). http://dx.doi.org/10.3389/fcell.2021.695900.
Full textDissertations / Theses on the topic "Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI"
Bonafede, Roberta. "Exosomes from mesenchymal stem cells: experimental assessment of an innovative therapeutic approach for ALS." Doctoral thesis, 2016. http://hdl.handle.net/11562/939082.
Full textAmyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by progressive muscular paralysis and degeneration of motoneurons in the primary motor cortex, brainstem and spinal cord. Mutations in superoxide dismutase 1 (SOD1) gene are one of the genetic contributor to ALS. Therapeutic strategies for ALS are actually minimally effective on patients’ survival and quality of life. Stem cells represent a promising therapeutic approach in the treatment of neurodegenerative diseases and their beneficial effect seem to be due through a paracrine effect via the release of extracellular vesicles, in particular exosomes.In this doctoral thesis, I describe the studies to assess the neuroprotective effect of exosomes derived from syngeneic adipose stem cells (ASC) on in vitro and in vivo models of ALS, and the protocol for exosomes labeling to monitor the accumulation of exosomes after their in vivo administration.In in vitro experiments, the administration of ASC-exosomes after oxidative insult (H2O2) on motoneuron-like cell line (NSC-34) naïve and transfected with different human mutant SOD1 gene (G93A, G37R, A4V), protected cells from oxidative damage, with a significantly increase of cell viability. In in vivo experiments, the intravenous injection of ASC-exosomes in SOD1(G93A) mice at clinical onset until terminal stage point out that exosomes delay symptoms progression and postpone lifespan of treated animals. Our results demonstrate that ASC-exosomes have a neuroprotective effect in in vitro and in vivo models of ALS, indicating a possible new strategy as therapy in this neurodegenerative disease. Moreover, we set up a new protocol to label exosomes with superparamagnetic iron oxide nanoparticles, that allow to evaluate their tracking and their accumulation in vivo with a non-invasive technique, as magnetic resonance imaging.