Academic literature on the topic 'Amphiphilic graft copolymer'
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Journal articles on the topic "Amphiphilic graft copolymer"
Christova, Darinka, Maya Staneva, Sijka Ivanova, Mariela Alexandrova, Philip Ublekov, Maria Dencheva-Zarkova, Julia Genova, Irene Tsibranska, and Bartosz Tylkowski. "Surface Modification of Polyethersulfon Nanofiltration Membrane for Improving Water-Ethanol Separation." Journal of Physics: Conference Series 2436, no. 1 (January 1, 2023): 012024. http://dx.doi.org/10.1088/1742-6596/2436/1/012024.
Full textGuo, Linlin, Ge Gao, Xiaoli Liu, and Fengqi Liu. "Emulsion Polymerisation of St/BuA Stabilised with a PEG-containing Graft Copolymer." Polymers and Polymer Composites 16, no. 9 (November 2008): 635–39. http://dx.doi.org/10.1177/096739110801600908.
Full textDemina, Tatiana S., Maria G. Drozdova, Chantal Sevrin, Philippe Compère, Tatiana A. Akopova, Elena Markvicheva, and Christian Grandfils. "Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers." Molecules 25, no. 8 (April 22, 2020): 1949. http://dx.doi.org/10.3390/molecules25081949.
Full textZhao, Fengfeng, Hui Quan, Shijun Zhang, Yihui Xu, Zheng Zhou, Guangxin Chen, and Qifang Li. "Watered-Based Graphene Dispersion Stabilized by a Graft Co-Polymer for Electrically Conductive Screen Printing." Polymers 15, no. 2 (January 10, 2023): 356. http://dx.doi.org/10.3390/polym15020356.
Full textYang, Yang, Lei Miao, Jiwen Hu, Guojun Liu, Yuanyuan Tu, Shudong Lin, Feng Liu, et al. "Hydrophilization of polysulfone membranes using a binary graft copolymer." J. Mater. Chem. A 2, no. 27 (2014): 10410–23. http://dx.doi.org/10.1039/c4ta01481b.
Full textMo, Yangmiao, Shudong Lin, Yuanyuan Tu, Guojun Liu, Jiwen Hu, Feng Liu, and Jun Song. "Unimolecular micelles from graft copolymer with binary side chains." RSC Advances 6, no. 64 (2016): 58871–83. http://dx.doi.org/10.1039/c6ra10822a.
Full textChern, Chorng-Shyan, Wen-Yih Chen, Hsin-Cheng Chiu, Fu-Hsiung Chang, Mimg-Hung Hsieh, and Jia-Ren Tu. "Interactions between amphiphilic graft copolymer-intercalated liposomes." Colloids and Surfaces A: Physicochemical and Engineering Aspects 277, no. 1-3 (April 2006): 44–51. http://dx.doi.org/10.1016/j.colsurfa.2005.11.006.
Full textZhou, Yong, and Zhi Guo Hu. "Synthesis of Chiral Amphiphilic Graft Copolymer PBTQMO-g-MPEO." Advanced Materials Research 308-310 (August 2011): 689–91. http://dx.doi.org/10.4028/www.scientific.net/amr.308-310.689.
Full textDas, Dipankar, Sudipta Mukherjee, Aniruddha Pal, Raghunath Das, Santi Gopal Sahu, and Sagar Pal. "Synthesis and characterization of biodegradable copolymer derived from dextrin and poly(vinyl acetate) via atom transfer radical polymerization." RSC Advances 6, no. 11 (2016): 9352–59. http://dx.doi.org/10.1039/c5ra22762c.
Full textJiang, Weihua, Ju Wang, Lei Yang, Xuewei Jiang, Zhaoshi Bai, Zheran Wang, Yunpeng He, and Dongkai Wang. "Nanostructured lipid carriers modified with PEGylated carboxymethylcellulose polymers for effective delivery of docetaxel." RSC Advances 5, no. 110 (2015): 90386–95. http://dx.doi.org/10.1039/c5ra13642c.
Full textDissertations / Theses on the topic "Amphiphilic graft copolymer"
Lovell, Nathan Gary. "Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62607.
Full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 99-106).
The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important niche between nonporous reverse osmosis membranes, which have comprehensive solute rejection and low solvent permeability, and porous sieving ultrafiltration membranes. However, challenges in NF membrane design remain outstanding. At the effective pore size of NF membranes (~0.5 nm-2 nm), both electrostatic and steric factors determine membrane selectivity. Most NF membranes are charged under a wide range of environmental conditions and thus preferentially exclude charged solutes. This charge selectivity precludes separation of molecules based solely on size. An additional limitation of NF membranes is the tendency to foul by adsorption of feed components. The purpose of this thesis is to demonstrate control of membrane selectivity in fouling resistant membranes via manipulation of the chemistry of a specific copolymer system, polyacrylonitrile (PAN)-based poly(ethylene oxide) (PEO) graft polymers. Previous work with amphiphilic graft copolymers as membrane materials has included PANg- PEO with an average graft length of 9 (PAN-g-PEO9). PAN-g-PEO9 was shown to have excellent fouling resistance as an antifouling additive in porous ultrafiltration membranes and as a dense selective layer coated onto a support base membrane-a thin-film composite (TFC) NF membrane. The comb morphology of the polymer imposes high interfacial area on the microphase-separated domains, resulting in a bicontinuous structure consisting of a glassy PAN matrix interpenetrated by PEO-filled "nanochannels" that can act as vias for water and small solutes (with a size cutoff of ~0.8 nm). It also presents a PEO brush on the comb surface which acts as a steric barrier to resist irreversible fouling of the membranes. The understanding from previous work on PEO comb NF membranes is that the pore size is determined by the nanochannel's size, i.e. the PEO domain size. Because the graft characteristics (spacing and length) of comb copolymers determine the domain size, it was expected that varying the graft length would allow broad, precise control of the size cutoff of the TFC membranes, a concept demonstrated previously with amphiphilic graft copolymer NF membranes of poly(vinylidene fluoride)-graft-poly(oxyethylene methacrylate) (PVDF-g-POEM). The first aim of this thesis was to tailor the retention properties of PAN-g-PEO TFC NF membranes by modifying the chemistry to tune the electrostatic and steric properties sufficiently to enable complex separations, particularly of solutes with high fouling potential. Comb copolymers incorporating ~40 weight % PEO with side chains varying from 5-40 EO units were synthesized by free radical methods and compared as selective-layer coatings on PAN UF membranes. 3 Membranes incorporating combs with 9 EO units or more were shown to resist irreversible fouling when challenged by a model protein feed solution (bovine serum albumin) for 24 hours. Fouling resistance was found to be compromised, however, upon exposure to acid (pH 2) solution, used to simulate chemical cleaning procedures in industry. Thickness-normalized permeabilities of these PAN-g-PEOn NF membranes exceeded those of commercially available NF membranes by approximately an order of magnitude. A systematic effect of side chain length on permeability was seen when varying temperature, ionic strength, and pressure. Contrary to expectations, the membrane size cutoff (~0.8 nm) for charged rigid molecular probes in deionized water was independent of the comb side chain length. This new finding can be explained by modeling the hydrophilic domains as opposing swollen polymer brushes of uniform density acting as a physical gel. The gel mesh size (distance between chains) is independent of side chain length, and controls the size cutoff in good solvent conditions matching those in which the membrane was equilibrated during fabrication. In poorer solvent conditions, a decrease in the brush height, progressing to complete collapse of the PEO gel, can be expected to create differentiation based on domain size (i.e. side chain length). This is consistent with the finding that retentions of dyes increased with decreasing side chain length in saline solution, as salt is known to reduce PEO-water miscibility. Fluorescently labeled peptides germane to proteomics research were filtered and both chromatographic and size-selective membrane behavior was observed-the first demonstration of size-based nanofiltration of peptides. Based on this finding, two different peptides of molecular weights 1.3kDa and 1.5kDa were fractionated to achieve a six-fold increase in the concentration of the larger peptide relative to the smaller peptide in two filtration steps. The electrostatic selectivity of the PEO comb membranes could also be varied. Terpolymers consisting of PAN-g-PEO with 1-2% charged sulfopropyl acrylate (SPA) or 5% N,Ndimethyl- N-(2-methacryloyloxyethyl-N-(3-sulfopropyl) ammonium betaine (SPE) were synthesized and coated onto PAN base membrane. The divalent salt (Na2SO4) retention of the resulting TFC membranes increased from ~20% for the PAN-g-PEO copolymer to ~45% and 82% for the SPE and SPA terpolymers, respectively. Retention of monovalent NaCl was substantially lower, characteristic of commercial NF membranes. The charged comb membranes did not completely resist fouling by a 1 g/L BSA solution, losing 2% of the initial flux after 24 h exposure. Forming a trilayer TFC, with a layer of PAN-g-PEO coated over a charged terpolymer, reduced membrane fouling compared to the charged layer alone. In summary, the goal of this study was to demonstrate control of membrane selectivity in fouling-resistant PAN-g-PEO NF membranes. An important finding was that the PEO gel created in the hydrophilic domains leads to similar size cutoffs over a wide range of side chain length. To access the desired spectrum of size cutoffs, the quality of solvent for the swollen PEO brush must be reduced. In spite of these limitations, the membrane was shown to have useful fractionating properties as demonstrated with labeled peptides of varying molecular weight. The retention of salts was enhanced by incorporating small amounts of charged monomer into the comb backbone, but at the expense of fouling resistance.
by Nathan Gary Lovell.
Ph.D.
Kuhlman, William A. "Presentation and accessibility of surface bound ligands on amphiphilic graft copolymer films." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39549.
Full textIncludes bibliographical references.
Amphiphilic comb-type graft copolymers comprising a poly(methyl methacrylate) (PMMA) backbone and short, polyethylene oxide (PEO) side chains, PMMA-g-PEO, are proposed to self-organize at the polymer/water interface, resulting in quasi-2D confinement of the backbone at the immediate surface. The branched architecture and amphiphilic chemistry of these polymers results in a dense PEO brush that resists cell adhesion. To facilitate specific cell-surface interactions, small biological molecules such as adhesion peptides can be selectively tethered to PEO chain ends. Quasi-2D confinement of the polymer backbone results in clustering of tethered epitopes on a length scale dictated by the backbone. The present work investigates two aspects of this polymer architecture on organization of tethered ligands: nanometer length-scale clustering through backbone 2D confinement, and tether length effects on the availability of tethered peptides for cell adhesion.
(cont.) To directly probe 2D confined polymer conformations, combs at the film/water interface were labeled with gold nanoparticles and observed by transmission electron microscopy. A 2D radius of gyration (Rg) was calculated by reconstructing nanoparticle-decorated chain trajectories, and compared with Monte Carlo simulations of a 2D melt of similarly broad length distribution. The 2D Rg calculated from observed conformations scaled with the number of backbone segments (N) as Rg - N.69-0.02 Monte Carlo simulations yielded a scaling exponent v = 0.67 + 0.03, suggesting that the deviation from classical 2D melt behavior (v= 0.5) arose from polydispersity. Tether length effects on cell adhesion to comb copolymer films functionalized with the adhesion peptide PHSRNGGGK(GGC)GGRGDSPY were further investigated by observing cell attachment and spreading on combs with long (22 EO unit) and short (10 EO unit) tethers. Lofiger tethers increased the rate of spreading and reduced the time required to form focal adhesions. Fluorescence resonance energy transfer (FRET) measurements suggest that the added mobility afforded by longer tethers allowed cells to reorganize tethered peptides.
(cont.) In addition, adhesion peptides were selectively coupled to short or long PEO tethers within a bimodal brush. Short peptide tethers in a bed of long inert chains did not promote cell attachment. Long peptide tethers with short inert chains resulted in cell attachment comparable to a monomodal brush of long chains. These findings may be of value in designing protein-resistant bioactive surfaces, where nanometer length-scale organization of ligands plays an important role in cell-surface interactions.
by William A. Kuhlman.
Ph.D.
Lapree-Delestre, Christine. "Synthèse et étude physico-chimique d'alginates substitues par des polyoxyalkylenes en vue d'applications d'intérêt biologique." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL156N.
Full textLauber, Lionel. "Control of the rheological properties of hydrogels made by self-assocation of amphiphilic copolymers, blocks and grafts, anionics or cationics." Thesis, Le Mans, 2016. http://www.theses.fr/2016LEMA1010/document.
Full textThe aim of this work was to control the rheological properties of aqueous solutions of amphiphilic copolymers. In water, these copolymers self-assemble and part of their properties can be controlled by their dynamic of exchange. As previously reported, the exchange dynamics can be controlled by the pH and the acrylic acid (AA) content for BAB triblock copolymers (THx) consisting of a poly(acrylic acid) (PAA) A block and two statistical B blocks (MHx) of n-butyl acryle (nBA) and AA.First, the study of the self-association of B blocks (MHx) alone showed a strong relationship between their aggregation and the one of BA diblocks (DHx). This aggregation was mainly controlled by the amount of charges within the B blocks.Then, mixtures of BAB triblocks (THx) with different contents of AA units, x, formed hybrid networks the rheological properties of which were controlled by formulation rather than chemistry.Similar rheological properties were obtained using graft copolymers consisting of a PAA hydrophilic backbone and B grafts. Their rheological properties were mainly controlled by the chemical structure of the B grafts and by the grafting density. Such graft copolymers should be easier to produce at an industrial scale than triblock copolymers.To finish, the strategy consisting of incorporating hydrophilic units inside the hydrophobic blocks of amphiphilic copolymers to control their exchange dynamics was successfully applied to copolymers made of dimethylaminoethyl methacraylate and n-butyl methacrylate. Their rheological properties were controlled by the pH on a different pH-range than the AA based polymers, and, to some extent, by the temperature
Zhang, Dapeng. "Synthèse de polyuréthanes par polymérisation par ouverture de cycle anionique et auto-assemblage de copolymères amphiphiles à base de polyuréthane." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEC007.
Full text1.Controlled anionic ring opening polymerization of 5-membered cyclic carbamates to polyurethanes. 2.Synthesis and self-assembly of polyurethane-based amphiphilic linear diblock copolymers. 3.Synthesis and self-assembly of polyurethane-based amphiphilic graft copolymers
Bayley, Gareth Michael. "Novel electrospun fibres of amphiphilic organic-inorganic graft copolymers of poly(acrylonitrile)-graftpoly( dimethylsiloxane) for silicone composite reinforcement." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/17875.
Full textENGLISH ABSTRACT: Novel silicone nanocomposites were prepared using poly(acrylonitrile) (PAN) based reinforcing fibres as well as multi-walled carbon nanotubes (MWCNTs). Compatibility of the fibre fillers with the silicone matrix required the synthesis of novel amphiphilic, organic–inorganic graft copolymers of PAN and poly(dimethylsiloxane) (PAN-g-PDMS). These fibre precursor materials were synthesised via the “grafting through” technique using conventional free radical copolymerisation. The PDMS macromonomer content in the feed was varied from 5 wt% to 25 wt% and the molecular weights of the macromonomer were 1000 g.mol-1 and 5000 g.mol-1. The solvent medium of the precipitation reaction was optimised at a volume ratio of 98% benzene to 2% dimethylformamide (DMF). Successful incorporation of PDMS yielded graft copolymer blend materials of PAN-g-PDMS, blended with PAN homopolymer and unreacted PDMS macromonomer. A gradient elution profile was developed to track the successful removal of the PDMS macromonomer via hexane extraction. The gradient profile showed that as the PDMS content in the feed increased, the number of graft molecules in the blend increased relative to the number of PAN homopolymer molecules. The crystallisability of the PAN segments was shown to decrease as the PDMS content increased. The synthesised polymer was used as precursor material for the electrospinning of fibre fillers. The electrospinning of the precursor material was successfully achieved using 100% DMF as electrospinning solution medium. The amphiphilic nature of the precursor material in DMF resulted in self-assembled aggregate structures in the electrospinning solution. An increasing PDMS content was shown to affect the aggregation of the precursor material, and resulted in an increase in the solution viscosity. The “gel-like” solutions limited the achievable fibre morphological control when altering conventional electrospinning parameters such as voltage, tip-to-collector distance, and solution concentrations. The rapid evaporation and stretching of the solution during electrospinning, combined with the phase segregated amphiphilic molecules in solution and the crystallisation of the PAN segments resulted in (non-equilibrium morphology) fully porous fibres. The crystallinity was shown to decrease after electrospinning of the fibre precursor materials. Successful incorporation of surface oxidised MWCNTs into the electrospun fibres was achieved. The content of nanotubes was varied from 2 wt% to 32 wt%. The MWCNTs reduced the mean fibre diameters by acting as cross-linkers between the PAN segments and increasing the solution conductivity. The nanotubes dispersed well throughout the porous structure of the fibres and aligned in the direction of the fibre axis. Fabrication of silicone composites containing nonwoven and aligned fibre mats (with 8 wt% MWCNTs in the fibres, and without) was successfully achieved. The compatibilisation of the PDMS surface segregated domains allowed excellent dispersion and interaction of the PAN based fibre fillers with the silicone matrix. Mechanical analysis showed improved properties as the PDMS content in the fibre increased. The highest PDMS content fibres did, however, exhibit decreased properties. This was ascribed to increased PDMS (soft and weak) content, decreased crystallinity and increased fibre diameter (lower interfacial area). Dramatic improvements in strength, stiffness, strain and toughness were achieved. The most significant result was an increase in strain of 470%. The mechanical results correlated with results of SEM analysis of the fracture surfaces. The dramatic improvements in properties were a result of the fibre strength and ductility, as well as the mechanism of composite failure.
AFRIKAANSE OPSOMMING: Nuwe silikonnanosamestellings is berei deur gebruik te maak van poli(akrilonitriel) (PAN) gebaseerde versterkende vesels wat multi-ommuurde koolstof nanobuisies bevat het. Versoenbaarheid van die vesels met die silikonmatriks het die sintese van nuwe amfifiliese, organies–anorganiese ent-kopolimere van PAN en poli(dimetielsiloksaan) (PAN-g-PDMS) benodig. Die vesel voorlopermateriaal is deur middel van ‘n “ent-deur” vryeradikaalkopolimerisasie gesintetiseer. Die inhoud van die PDMS makromonomeer in die reaksie het gewissel vanaf 5% tot 25%. Die gebruik van twee verskillende molekulêre massas makromonomere is bestudeer (1000 en 5000 g.mol-1). Die optimale oplosmiddelmengsel vir die neerslagreaksie was 'n volume verhouding van 98% benseen tot 2% dimetielformamied (DMF). Suksesvolle insluiting van PDMS het versnitmateriale van PAN-g-PDMS kopolimere gemeng met PAN homopolimere en ongereageerde PDMS makromonomere gelewer. 'n Gradiënteluering- chromatografiese profiel is ontwikkel om die suksesvolle verwydering van die PDMS makromonomere via heksaanekstraksie te bepaal. Die gradiëntprofiel het aangetoon dat indien die PDMS inhoud in die reagense verhoog is, die aantal entmolekules relatief tot PAN homopolimeermolekules ook verhoog het. 'n Toename in PDMS inhoud het egter 'n afname in kristallisasie van die PAN segmente tot gevolg gehad. Die gesintetiseerde polimeer is gebruik as die beginmateriaal vir die elektrospin van veselvullers. Die elektrospin van die beginmateriaal was suksesvol wanneer 100% DMF as elektrospinoplosmiddel gebruik is. Die amfifiliese aard van die beginmateriaal in DMF lei tot outokonstruksie van aggregaatstrukture in die elektrospinoplossing. Toenemende PDMS inhoud beïnvloed die outokonstruksie van die molekules in oplossing en het gelei tot 'n toename in die oplossings se viskositeit. Die "gelagtige" oplossings beperk die haalbare vesel se morfologiese beheerbaarheid wanneer konvensionele elektrospin parameters soos elektriese spanning, punt-tot-versamelaar afstand, en oplossingkonsentrasies gewysig word. Die vinnige verdamping en strek van die oplossing tydens elektrospin, gekombineer met die fase-geskeide amfifiliese molekules in oplossing en die kristallisasie van die PAN segmente, het gelei tot (nie-ewewig morfologie) volledige poreuse vesels. Die kristalliniteit van die veselbeginmaterial het afgeneem nadat elektrospin toegepas is. Die insluiting van die oppervlak-geoksideerde multi-ommuurde koolstof nanobuisies in die elektrogespinde vesels was suksesvol. Die inhoud van die nanobuisies het gewissel van 2 wt% tot 32 wt%. Die MWCNTs het die gemiddelde veseldeursnit verminder deur op te tree as kruisbinders tussen die PAN segmente van die molekules. Die nanobuisies was goed versprei deur die poreuse struktuur van die vesels en dit was gerig in die rigting van die vesel-as. Bereiding van die silikonsamestellings bestaande uit nie-geweefde en gerigte veseloppervlakke (met en sonder 8 wt% multi-ommuurde koolstof nanobuisies in die vesel) was suksesvol. Die versoenbaarheid tussen die oppervlak van die PDMS-geskeide gebiede en die silikonmatriks laat uitstekende verspreiding en interaksie van die PAN-gebaseerde veselvullers met die silikonmatriks toe. Meganiese analise het aangetoon dat die fisiese eienskappe verbeter het namate die PDMS inhoud in die vesel vermeerder het. Die vesels met die hoogste PDMS inhoud het egter verswakte eienskappe getoon. Dit is toegeskryf aan ‘n verhoogde PDMS inhoud (sag en swak), ‘n afname in kristalliniteit en ‘n verhoogde veseldeursnit (laer grensoppervlakke). Dramatiese verbeterings in sterkte, styfheid, verlengbaarheid, vervorming en taaiheid is bereik. Die mees betekenisvolle gevolg was 'n toename in die verrekking van 470%. Die meganiese resultate is gekorreleer met SEM ontleding van die brekingsoppervlakke. Die veselkrag en vervormbaarheid, sowel as die meganisme van die splyting van die samestellings, het tot die dramatiese verbeterings in die meganiese eienskappe gelei.
Breitenkamp, Rebecca Boudreaux. "Oligopeptide-functionalized Graft Copolymers: Synthesis and Applications in Nucleic Acid Delivery." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/open_access_dissertations/5/.
Full textMeltz, Freda-Jean. "Amphiphilic electrospun fibres of poly(methacrylic acid)-graft-poly(dimethylsiloxane) copolymers as a means to controlling electrospun fibre morphology and obtaining nanofibre hydrogels." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86620.
Full textENGLISH ABSTRACT: Novel poly(methacrylic acid)-graft-poly(dimethylsiloxane) copolymers were synthesised by conventional free radical reactions using a poly(dimethylsiloxane) macromonomer. The polymers were electrospun to investigate how the fibre morphology can be modified by manipulating the electrospinning solution parameters, and to determine the possibility of using the polymers as new materials for the production of polymer nanofibre hydrogels. The electrospinning solution parameters were varied by electrospinning the highly amphiphilic copolymers in solvents with variable solvent qualities. Scanning Electron Microscopy (SEM) and Field Emission Scanning Electron Microscopy (FE–SEM) was used to investigate the fibre morphology. Internal morphology was studied using a freeze fracture technique prior to FE-SEM imaging. It is revealed that the polymers in this study does not form any fine structure or pores even when self-assembled structures are present in the solution. Attempts were made to visualise any self-assembled structures of films produced from dilute solutions using TEM. Further studies included investigating the fibres properties, primarily with regards to their rate and extent of moisture and water uptake. The fibres showed hydrogel behaviour and the PDMS content were found to have an impact on the hydrogel stability. Post electrospinning crosslinking of the nanofibres was also explored.
AFRIKAANSE OPSOMMING: Unieke ent-kopolimere wat bestaan uit poli(metielakrielsuur) (PMAS) en poli(dimetielsiloksaan) (PDMS) is gesintetiseer deur middel van 'n “ent-deur” vryeradikaalkopolimerisasie. 'n PDMS makromonomeer is vir hierdie doel gebruik. Die polimere is geëlektrospin om vesels te vorm. Die doel was om die invloed van verkillende strukture in oplossing op die veselmorfologie te bepaal. Die moontlikheid om hierdie nanovesels as gels te gebruik is ook ondersoek. Die amfifiliese kopolimere is geëlektrospin uit die oplossing waarin dit wisselende oplosbaarheid toon. Skandeer elektron mikroskopie (SEM) is gebruik om die morfologie te ondersoek. Die interne morfologie van die vesels is ondersoek deur die vesels te vries en in die gevriesde toestand te breek. Die studie het getoon dat geen strukture op, of binne, die vesels vorm nie, selfs al moes daar assosiasie tussen segmente van die polimere gewees het. Hierdie tipe assosiasies sou strukture in die oplossing tot gevolg gehad het. 'n Poging is aangewend om die strukture in oplossing te visualiseer deur transmissie elektron mikroskopie (TEM) van dun films te ondersoek. Films is vanaf verdunde oplossings gevorm. Ander studies het ingesluit om die eienskappe van die vesels te ondersoek, met die fokus op hoeveel en hoe vinnig die vesels waterdamp en water kon absorbeer. Die vesels het soos 'n gel reageer. Hierdie gedrag is beïnvloed deur die hoeveelheid PDMS wat 'n definitiewe invloed op die stabiliteit van die gel gehad het. Kruisverbindings van die vesels, nadat dit geëlektrospin is, is ook ondersoek.
Delorme, Victor. "Nouveaux systèmes copolymères amphiphiles biodégradables pour la délivrance de principes actifs anticancéreux." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS140.
Full textThis work presents the synthesis of biocompatible and biodegradable amphiphilic copolymers for the formation of anticancer drug delivery systems. These copolymers consist of a poly-(ε-caprolactone) (PCL) chain, a biocompatible and biodegradable hydrophobic polyester, on which hydrophilic oligomers of dextrane or chitosane are grafted. These new copolymer structures are called “reverse” structures, the “classic” ones being made of a polysaccharide chain with PCL grafts. The PCL chain was propargylated via an anionic method developed by our team, while azide functions were grafted on oligosaccharides at a chain end of dextrane, but along the chain in chitosan, thanks to its amine functions. Copolymers were obtained by CuAAC click coupling between the activated PCL and oligosaccharides. In the case of chitosan, the amines of the chain allowed the coupling of mannose squarate, a cancer cell targeting agent, as well as a functionalization in the form of thiols which allow coupling by thiol-yne reaction on propargylated PCL. These copolymers form nano objects in aqueous media which, in the case of the PCL-g-dextrane structure, are forming micelles that encapsulate doxorubicin, which is further released in a pH- dependent way. Biological studies have shown that these charged micelles are toxic to cancer cells and not to healthy cells and are preferentially internalized by cancer cells. These results demonstrate a high degree of selectivity of action against tumor cells
BIANCHI, ALBERTO. "Living radical polymerization for the preparation of innovative macromolecular architectures." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41784.
Full textBook chapters on the topic "Amphiphilic graft copolymer"
Riess, Gérard. "Polymer Micelles: Amphiphilic Block and Graft Copolymers as Polymeric Surfactants." In Handbook of Industrial Water Soluble Polymers, 174–238. Oxford, UK: Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470988701.ch7.
Full textBreitenkamp, Kurt, Denise Junge, and Todd Emrick. "Hollow Microcapsules for Drug Delivery by Self-Assembly and Cross-Linking of Amphiphilic Graft Copolymers." In ACS Symposium Series, 253–67. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0923.ch018.
Full text"Preparation, Self-Assembly, and Application of Amphiphilic Cellulose-Based Graft Copolymers." In Cellulose-Based Graft Copolymers, 414–45. CRC Press, 2015. http://dx.doi.org/10.1201/b18390-22.
Full textConference papers on the topic "Amphiphilic graft copolymer"
Krajangpan, Sita, Achintya Bezbaruah, and Bret Chisholm. "Groundwater Arsenic Remediation Using Amphiphilic Polysiloxane Graft Copolymer Coated Iron Nanoparticles." In World Environmental and Water Resources Congress 2011. Reston, VA: American Society of Civil Engineers, 2011. http://dx.doi.org/10.1061/41173(414)111.
Full textBendaikha, H., G. Clisson, A. Khoukh, J. François, S. Ould Kada, A. Krallafa, Alberto D’Amore, Domenico Acierno, and Luigi Grassia. "Synthesis and Characterization of Amphiphilic Graft Copolymers of Poly (1,3dioxolane) Macromonomers with Styrene and Methyl Methacrylate." In IV INTERNATIONAL CONFERENCE TIMES OF POLYMERS (TOP) AND COMPOSITES. AIP, 2008. http://dx.doi.org/10.1063/1.2989058.
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