Relevant bibliographies by topics / Amphiphile

Academic literature on the topic 'Amphiphile'

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Published: 4 June 2021
Last updated: 21 February 2023

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Journal articles on the topic "Amphiphile"

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Lombardo, Domenico, Mikhail A. Kiselev, Salvatore Magazù, and Pietro Calandra. "Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches." Advances in Condensed Matter Physics 2015 (2015): 1–22. http://dx.doi.org/10.1155/2015/151683.

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Amphiphiles are synthetic or natural molecules with the ability to self-assemble into a wide variety of structures including micelles, vesicles, nanotubes, nanofibers, and lamellae. Self-assembly processes of amphiphiles have been widely used to mimic biological systems, such as assembly of lipids and proteins, while their integrated actions allow the performance of highly specific cellular functions which has paved a way for bottom-up bionanotechnology. While amphiphiles self-assembly has attracted considerable attention for decades due to their extensive applications in material science, drug and gene delivery, recent developments in nanoscience stimulated the combination of the simple approaches of amphiphile assembly with the advanced concept of supramolecular self-assembly for the development of more complex, hierarchical nanostructures. Introduction of stimulus responsive supramolecular amphiphile assembly-disassembly processes provides particularly novel approaches for impacting bionanotechnology applications. Leading examples of these novel self-assembly processes can be found, in fact, in biosystems where assemblies of different amphiphilic macrocomponents and their integrated actions allow the performance of highly specific biological functions. In this perspective, we summarize in this tutorial review the basic concept and recent research on self-assembly of traditional amphiphilic molecules (such as surfactants, amphiphile-like polymers, or lipids) and more recent concepts of supramolecular amphiphiles assembly which have become increasingly important in emerging nanotechnology.
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Edwards, D. A., Z. Liu, and R. G. Luthy. "Enhancing Polynuclear Aromatic Uptake into Bulk Solution with Amphiphilic Colloidal Aggregates." Water Science and Technology 26, no. 9-11 (November 1, 1992): 2341–44. http://dx.doi.org/10.2166/wst.1992.0732.

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Aggregated amphiphiles in an aqueous or solid/aqueous system can substantially enhance the uptake of polynuclear aromatic (PNA)compound into a bulk solution. The extent of PNA compound incorporated in an amphiphilic aggregate solution in the absence of solids is linearly dependent on the bulk solution concentration of the aggregated form of the amphiphile. In a system in which solids are in contact with a solution, however, the relationship is nonlinear as a result of the adherence of both amphiphile and PNA compound to the solids. The formation of amphiphile aggregates in the bulk solution of a system containing solids occurs only after a much greater amount of amphiphile has been added to the system than would be required for a similar system containing only solution. The partitioning of PNA compound between the solid, the colloidal amphiphilic aggregates in bulk solution, and the rest of the bulk solution can be characterized with two different partition coefficients and a number of other parameters, all of which are obtainable from independent experiments. The total fraction of PNA compound incorporated into bulk solution can be estimated with a mathematical model. Model results for the uptake of pyrene into a C8PE9.5 aggregate solution are shown plotted with experimental data. The effect of amphiphile aggregates on PNA compound transport in porous media may in some cases be substantial.
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Brahmachari, Sayanti, Sisir Debnath, Sounak Dutta, and Prasanta Kumar Das. "Pyridinium based amphiphilic hydrogelators as potential antibacterial agents." Beilstein Journal of Organic Chemistry 6 (September 21, 2010): 859–68. http://dx.doi.org/10.3762/bjoc.6.101.

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The numerous applications of hydrogelators have led to rapid expansion of this field. In the present work we report the facile synthesis of amphiphilic hydrogelators having a quaternary pyridinium unit coupled to a hydrophobic long alkyl chain through an amide bond. Different amphiphiles with various hydrophobic chain length and polar head groups were rationally designed and synthesized to develop a structure-property relation. A judicious combination of hydrophilic and hydrophobic segments led to the development of pyridinium based amphiphilic hydrogelators having a minimum gelation concentration of 1.7%, w/v. Field emission scanning electronic microscopy (FESEM), atomic force microscopy (AFM), photoluminescence, FTIR studies, X-ray diffraction (XRD) and 2D NOESY experiments were carried out to elucidate the different non-covalent interactions responsible for the self-assembled gelation. The formation of three-dimensional supramolecular aggregates originates from the interdigitated bilayer packing of the amphiphile leading to the development of an efficient hydrogel. Interestingly, the presence of the pyridinium scaffold along with the long alkyl chain render these amphiphiles inherently antibacterial. The amphiphilic hydrogelators exhibited high antibacterial activity against both Gram-positive and Gram-negative bacteria with minimum inhibitory concentration (MIC) values as low as 0.4 μg/mL. Cytotoxicity tests using MTT assay showed 50% NIH3T3 cell viability with hydrogelating amphiphile 2 up to 100 μg/mL.
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Cretu, Carmen, Loredana Maiuolo, Domenico Lombardo, Elisabeta I. Szerb, and Pietro Calandra. "Luminescent Supramolecular Nano- or Microstructures Formed in Aqueous Media by Amphiphile-Noble Metal Complexes." Journal of Nanomaterials 2020 (October 13, 2020): 1–24. http://dx.doi.org/10.1155/2020/5395048.

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The involvement of metal ions within the self-assembly spontaneously occurring in surfactant-based systems gives additional and interesting features. The electronic states of the metal, together with the bonds that can be established with the organic amphiphilic counterpart, are the factors triggering new photophysical properties. Moreover, the availability of stimuli-responsive supramolecular amphiphile assemblies, able to disassemble in a back-process, provides reversible switching particularly useful in novel approaches and applications giving rise to truly smart materials. In particular, small amphiphiles with an inner distribution, within their molecular architecture, of various polar and apolar functional groups, can give a wide variety of interactions and therefore enriched self-assemblies. If it is joined with the opportune presence and localization of noble metals, whose chemical and photophysical properties are undiscussed, then very interesting materials can be obtained. In this minireview, the basic concepts on self-assembly of small amphiphilic molecules with noble metals are shown with particular reference to the photophysical properties aiming at furnishing to the reader a panoramic view of these exciting problematics. In this respect, the following will be shown: (i) the principles of self-assembly of amphiphiles that involve noble metals, (ii) examples of amphiphiles and amphiphile-noble metal systems as representatives of systems with enhanced photophysical properties, and (iii) final comments and perspectives with some examples of modern applications.
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Park, Kyeng Min, Moon Young Hur, Suman Kr Ghosh, Deepak Ramdas Boraste, Sungwan Kim, and Kimoon Kim. "Cucurbit[n]uril-based amphiphiles that self-assemble into functional nanomaterials for therapeutics." Chemical Communications 55, no. 72 (2019): 10654–64. http://dx.doi.org/10.1039/c9cc05567c.

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In this feature article, the two types (molecular amphiphile and supramolecular amphiphile) of CB-based amphiphiles, their self-assemblies and their applications for useful nanotherapeutics and theranostics are presented with future perspectives.
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Shida, Claudio S., and Vera B. Henriques. "Monte Carlo Comparative Study of Model Detergent and Lipid Aggregation on a Lattice." International Journal of Modern Physics C 09, no. 06 (September 1998): 801–7. http://dx.doi.org/10.1142/s0129183198000728.

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We have studied the aggregation of model amphiphilic molecules on a square lattice through Monte Carlo simulations via Metropolis. Amphiphilic molecules are modeled with a hydrophilic head represented by a small set of "water-loving" sites whereas the hydrophobic double-tail is represented by a second set of oil-loving sites. We have compared aggregation properties of single-stail (detergents) and double-tail (phospholipids) amphiphiles with equivalent hydrophobicity ratios. Equilibrium quantities such as average particle energy, specific heat, free amphiphile density show similar behavior for both model systems. The transition region associated with aggregation occurs at high temperatures for phospholipids as compared to detergents.
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George, M., and I. van de Rijn. "Nutritionally variant streptococcal serotype I antigen. Characterization as a lipid-substituted poly(ribitol phosphate)." Journal of Immunology 140, no. 6 (March 15, 1988): 2008–15. http://dx.doi.org/10.4049/jimmunol.140.6.2008.

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Abstract Initial characterization of the nutritionally variant streptococcal serotype I amphipathic polymer indicated an estimated m.w. of 360,000 for the aggregated form of the molecule, whereas the dissociated form had an estimated m.w. of 38,000 based on dextran m.w. standards. In addition, SDS-PAGE indicated an amphiphile with a stepladder appearance made up of several components with m.w. larger than the major electrophoresis components of LPS or lipoteichoic acid. Chemically, the serotype I amphiphile appeared to be a lipid-substituted poly(ribitol phosphate) with galactose and alanine substitution on the ribitol phosphate backbone. This report represents the first characterization of a bacterial amphiphile with a chemical composition and structure as proposed here. As is the case with other bacterial amphiphiles, the nutritionally variant streptococcal serotype I amphiphile was found both intra- and extracellularly. Finally, immunofluorescence studies demonstrated that the amphiphile was expressed on the cell surface.
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Wang, Feng Yan, and Ti Feng Jiao. "Synthesis of Gold Nanoparticles by Using a Bolaform Schiff Base Amphiphile at Liquid-Liquid Interface." Advanced Materials Research 490-495 (March 2012): 3694–97. http://dx.doi.org/10.4028/www.scientific.net/amr.490-495.3694.

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Gold nanoparticles were synthesized via a bolaform amphiphile with hydrophilic ethyleneamine spacer at a liquid-liquid interface. By stirring the aqueous solution containing AuCl4- ions with the chloroform solution of bolaform amphiphile, AuCl4- ions were transferred into the oil phase and reduced to gold nanoparticles. UV-vis and FT-IR spectral measurements indicated that the bolaform amphiphile could serve as both capping and reducing agents. Crystalline gold nanoparticles were predominantly obtained if the bolaform amphiphile solutions with appropriate concentrations were applied. The generated gold nanoparticles were characterized by UV-vis spectroscopy and atomic force spectroscopy (AFM). It is predicted that gold and other novel metal nanostructures may be produced by bolaform amphiphiles whose properties can be well-controlled by designing different headgroups, spacers or substituted groups.
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Białkowska, Katarzyna, Małgorzata Bobrowska-Hägerstrand, and Henry Hägerstrand. "Expansion of Phosphatidylcholine and Phosphatidylserine/Phosphatidylcholine Monolayers by Differently Charged Amphiphiles." Zeitschrift für Naturforschung C 56, no. 9-10 (October 1, 2001): 826–30. http://dx.doi.org/10.1515/znc-2001-9-1024.

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Abstract Monolayer Technique, Nonionic Detergent, Erythrocyte Shape The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 °C) were followed. Amphiphiles were added to the sub-phase at a concentration/monolayer area corresponding to the concentration/erythrocytes surface area where sphero-echinocytic or sphero-stomatocytic shapes are induced (0.46-14.6 μᴍ). Nonionic, cationic and anionic am­ phiphiles expanded the PS/PC monolayer significantly more (1.7-4.2 times) than the PC monolayer. A zwitterionic amphiphile expanded both monolayers to a similar extent. The initial rate of monolayer-expansion was higher for all amphiphiles (1.7-20.4 times) in the PS/PC monolayer than in the PC monolayer.It is suggested that hydrophobic interactions govern the intercalation of amphiphiles into monolayers, and that monolayer packing, modulated by phospholipid head group interactions and alkyl chain saturation, strongly influence amphiphile intercalation. A possible relation between the monolayer-expanding effect of amphiphiles and their effect on erythrocyte shape is discussed.
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Wu, Zhen Dong. "Preparation of Gold Nanoparticles by Using Cholesteryl Compounds." Applied Mechanics and Materials 368-370 (August 2013): 795–98. http://dx.doi.org/10.4028/www.scientific.net/amm.368-370.795.

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Gold nanoparticles were synthesized by two bolaform cholesteryl imide derivatives with different lengths of ethyleneamine spacers at a liquid-liquid interface. By stirring the aqueous solution containing AuCl4- ions with the chloroform solution of bolaform amphiphile, AuCl4- ions were transferred into the organic phase and reduced to gold nanoparticles. Spectral and morphological measurements indicated that both bolaform amphiphiles could serve as both capping and reducing agents. Different gold nanostructures could be obtained depending on the different spacers and the molar ratios of amphiphile to AuCl4- ions.
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Dissertations / Theses on the topic "Amphiphile"

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Bui, Laurent. "Assemblages de copolymères à blocs pour la vectorisation de siRNA." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14457/document.

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Les « siRNA » sont des molécules double brin d’acide ribonucléique capables d’inhiber l’expression d’un gène spécifique, présentant ainsi un fort potentiel thérapeutique pour les maladies génétiques, les cancers et les infections virales. Cependant, son utilisation in vivo est restreinte par sa sensibilité à la dégradation enzymatique. Le projet de thèse consiste à créer un système de vectorisation des siRNA pour des applications in vivo. Nous avons synthétisé des copolymères à blocs amphiphiles biocompatibles et biodégradables capable de s’auto-assembler en diverses structures et d’encapsuler les siRNA. Les propriétés physico-chimiques des assemblages formées et l’évaluation cellulaire préliminaire est réalisée
Amphiphilic block copolymers are molecules composed of hydrophilic and hydrophobic segments having the capacity to spontaneously self-assemble into a variety of supramolecular structures like micelles and vesicles. Here, we propose an original way to self-assemble amphiphilic block copolymers into a supported bilayer membrane for defined coating of nanoparticles. The heart of the method rests on a change of the amphiphilicity of the copolymer that can be turned off and on by varying the polarity of the solvent. In this condition, the assembly process can take advantage of specific molecular interactions in both organic solvent and water. The higher gene silencing activity of the copolymer-modified complexes over the complexes alone shows the potential of this new type of nanoconstructs for biological applications, especially for the delivery of therapeutic biomolecules
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Rother, Gernot. "Adsorption und Phasentrennung binärer flüssiger Mischungen in Porensystemen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967402883.

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Hohner, Andreas. "Amphiphile und Makromoleküle: Phasenverhalten hybrider Mizellen." [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00004697.

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Hohner, Andreas. "Amphiphile und Makromoleküle: Phasenverhalten hybrider Mizellen." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-46973.

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Chooi, Kar Wai. "A new class of polymeric amphiphile." Thesis, University of Strathclyde, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443137.

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Lacanau, Valentin. "Conception et étude physico-chimique d’amphiphiles auto-assemblés pour l’extraction de métaux et la catalyse en milieu aqueux." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS127.

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Ce projet vise à étudier et développer un principe novateur pour la valorisation de métaux issus du recyclage, en particulier du Pd, consistant en l’utilisation directe d’une phase organique issue d’une extraction liquide-liquide pour effectuer des réactions organo-catalysées en phase micellaire aqueuse. Le passage du Pd de la phase organique à la phase aqueuse est assuré par des tensio-actifs (TA) développés par l’équipe CBSA de l’IBMM (C. Pépin & F. Bonneté), et dont la structure vise à être optimisée afin de répondre aux contraintes liées à la récupération par voie hydrométallurgique du Pd issu de déchets électroniques, assurée par l’équipe LHYS de l’ICSM (D. Bourgeois). Suite à une preuve de concept récemment acquise en partenariat entre ces deux équipes du LabexCheMISyst et une équipe de Strasbourg (UdS, F. Bihel), il s’agit ici d’établir de façon rationnelle une relation entre la structure des TA, modulable à façon, les propriétés physico-chimiques des assemblages résultant de leur auto-association, et leur aptitude à contre-extraire puis stabiliser le Pd en phase aqueuse. Les connaissances fondamentales ainsi acquises permettraient alors une valorisation efficace de ces systèmes
This project aims to study and develop a novel principle dedicated to the valorisation of recycled metals, especially palladium. It consists in the direct use of an organic phase arising from a solvent extraction process into organo-catalyzed cross-couplings performed in aqueous micellar phases. The palladium transposition from the organic phase into the aqueous phase is performed thaks to surfactants developed by the CBSA team (C. Pépin & F. Bonneté, IBMM), and which structure has to be optimized to answer to the specifications linked with the hyrometallurgical processes dedicated to palladium recovery from electronic wastes, performed by the LHYS team (D. Bourgeois, ICSM). Following a recent proof of concept involving these both teams from the ChemiSyst LabEx and a third team from the Strasbourg University (F. Bihel), the present project will consist in the rational description of the relationship between the surfactants, easily tunable, the physic-chemical properties resulting from their auto-assembly, and their aptitude to back-extract and stabilize the palladium in the aqueous medium. The fundamental knowledge thus acquired will enable and efficient valorization of the proposed systems
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Rossbach, Benjamin Malte. "Amphiphile Makrosalen-Komplexe in der asymmetrischen Katalyse." [S.l.] : [s.n.], 2006. http://mediatum2.ub.tum.de/doc/604373/document.pdf.

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Zarka, Michael Tobias. "Neue amphiphile Blockcopolymere für die mizellare Katalyse." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972766340.

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Brindle, David. "Lattice models of amphiphile and solvent mixtures." Thesis, Sheffield Hallam University, 1991. http://shura.shu.ac.uk/19397/.

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Materials based on amphiphilic molecules have a wide range of industrial applications and are of fundamental importance in the structure of many biological systems. Their importance derives from their behaviour as surface-active agents in solubilization applications and because of their ability to form systems with varying degrees of structural order such as micelles, bilayers and liquid crystal phases. The nature of the molecular ordering is of importance both during the processing of these materials and in their final application. A Monte Carlo simulation of a three dimensional lattice model of an amphiphile and solvent mixture has been developed as an extension of earlier work in two dimensions. In the earlier investigation the simulation was carried out with three segment amphiphiles on a two dimensional lattice and cluster size distributions were determined for a range of temperatures, amphiphile concentrations and intermolecular interaction energies. In the current work, a wider range of structures are observed including micelles, bilayers and a vesicle. The structures are studied as a function of temperature, chain length, amphiphile concentration and intermolecular interaction energies. Clusters are characterised according to their shape, size and surface roughness. A detailed temperature-concentration phase diagram is presented for a system with four segment amphiphiles. The phase diagram shows a critical micelle concentration (c.m.c) at low amphiphile concentrations and a transition from a bicontinuous to lamellar region at amphiphile concentrations around 50%. At high amphiphile concentrations, there is some evidence for the formation of a gel. The results obtained question the validity of current models of the c.m.c. The Monte Carlo simulations require extensive computing power and the simulation was carried out on a transputer array, where the parallel architecture allows high speed. The development of a suitable parallel algorithm is discussed. A mean field model of a bilayer is presented which has similar interaction potentials as the Monte Carlo model. The ordering of the bilayer is examined as a function of chain length, bilayer thickness, temperature and inter molecular interaction energies. In this approximation a phase transition to the ordered bilayer is observed.
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Chen, Chao. "Amphiphilic dendrimers for siRNA delivery." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4738.

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Le défi majeur de la thérapie génique à base de siARN est sa délivrance sûre et efficace. Récemment, notre groupe a mis au point des dendrimères amphiphiles comme vecteurs robustes et efficaces de délivrance non-virale de siARN, qui combinent les avantages de délivrance des vecteurs lipidiques et polymèriques. J’ai effectué au cours de ma thèse de doctorat une analyse de la relation structure/activité (SAR) d'une série de dendrimères comportant des queues hydrophobes de différentes longueurs. Nos résultats démontrent qu’un équilibre optimal entre la longueur de la chaîne alkyle hydrophobe et la partie hydrophile dendritique joue un rôle crucial sur leur capacité d’auto-assemblage, ainsi que sur leur activité de transport des siRNA. En outre, en combinant bola-amphiphiles et nos dendrimères amphiphiles, nous avons développé un nouveau dendrimère bola-amphiphile dont nous avons étudié les propriétés d’auto-assemblage et l'efficacité de transport du siARN correspondant. Ce dendrimère bola-amphiphile particulier a été en mesure de réagir à des espèces réactives de l'oxygène pour la délivrance spécifique, ouvrant ainsi de nouvelles perspectives pour la conception de vecteurs stimuli-déclencheurs pour siARN ciblés. Enfin, nous avons étudié l’«effet d'éponge à protons» des vecteurs dendritiques amphiphiles à l'aide de la technique du film Langmuir en monocouche. Nos résultats ont prouvé le gonflement des vecteurs dendritiques amphiphiles par protonation, offrant ainsi des données expérimentales permettant de soutenir sans ambiguïté l’hypothèse de l'«effet d'éponge à protons»
A key challenge in RNAi-based gene therapy is the safe and effective siRNA delivery. Recently, our group has established amphiphilic dendrimers as robust and effective nonviral delivery vectors for siRNA, which combine the beneficial delivery features of both lipid and dendritic polymer vectors while overcoming their shortcomings.With the desire to understand the underlying mechanism of amphiphilic dendrimers for efficient delivery, I performed a structure/activity relationship (SAR) analysis of a series of dendrimers featuring hydrophobic tails of different lengths during my PhD thesis. We systematically investigated these dendrimers for their self-assembling characters and their capacities for both binding and delivery of siRNA. Our results demonstrate that an optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion plays a crucial role in the self-assembly and the delivery activity towards siRNA.Furthermore, we developed a novel bola-amphiphilic dendrimer by combining bola-amphiphiles and our amphiphilic dendrimers and studied their self-assembly properties and the corresponding siRNA delivery efficiency. This peculiar bola-amphiphilic vector was able to respond to reactive oxygen species for specific delivery, opening a new perspective for the design of stimuli-trigged vectors for targeted siRNA delivery.Finally, I studied the “proton sponge effect” of the amphiphilic dendrimer vectors using the Langmuir monolayer film technique. Our results gave direct evidence of swelling of the amphiphilic dendrimers upon protonation, offering unambiguous experimental data to support the “proton sponge effect”
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Books on the topic "Amphiphile"

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T, Nylander, and Lindman Björn 1942-, eds. Lipids and polymer-lipid systems. Berlin: Springer, 2002.

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Ilies, Marc A., ed. Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. Washington, DC: American Chemical Society, 2017. http://dx.doi.org/10.1021/bk-2017-1271.

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Zhang, Xi, ed. Supramolecular Amphiphiles. Cambridge: Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781788010566.

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Texter, J., ed. Amphiphiles at Interfaces. Darmstadt: Steinkopff, 1997. http://dx.doi.org/10.1007/3-798-51084-9.

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R, Nagarajan. Amphiphiles: Molecular assembly and applications. Washington, DC: American Chemical Society, 2011.

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Nagarajan, Ramanathan, ed. Amphiphiles: Molecular Assembly and Applications. Washington, DC: American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1070.

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Patrickios, Costas S., ed. Amphiphilic Polymer Co-networks. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788015769.

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Meunier, Jacques, Dominique Langevin, and Nino Boccara, eds. Physics of Amphiphilic Layers. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-83202-4.

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O'Keefe, Deirdre C. Supramolecular properties of amphiphilic cyclodextrins. Dublin: University College Dublin, 1998.

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E, Pelezetti, ed. Surfactants in analytical chemistry: Applications of organized amphiphilic media. Amsterdam: Elsevier, 1996.

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Book chapters on the topic "Amphiphile"

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Deamer, David. "Amphiphile." In Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_67-3.

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Deamer, David. "Amphiphile." In Encyclopedia of Astrobiology, 90–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_67.

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Deamer, David. "Amphiphile." In Encyclopedia of Astrobiology, 43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_67.

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Barrett, John C., and Matthew V. Tirrell. "Peptide Amphiphile Micelles for Vaccine Delivery." In Methods in Molecular Biology, 277–92. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7893-9_21.

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Kahlweit, M., R. Strey, and J. Jen. "Phase Behavior of Ternary Systems H2O — Oil — Amphiphile as Determined by the Interplay of the Oil — Amphiphile Gap and the H2O — Amphiphile Loop." In Progress in Microemulsions, 61–71. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4899-0809-4_4.

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Kaur, Kuljeet, Yun Qian, and John B. Matson. "H2S Delivery from Aromatic Peptide Amphiphile Hydrogels." In Biomaterials for Tissue Engineering, 193–208. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7741-3_15.

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Sukegawa, Takeshi, Masao Matsuda, Shin-Ichiro Nishimura, Masatsugu Shimomura, Kunihiro Ijiro, and Oraf Karthaus. "Synthesis and Self-Organisation of New Cyclodextrin Amphiphile." In Molecular Recognition and Inclusion, 519–22. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5288-4_98.

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Bagdassarian, C. K., D. Roux, A. Ben-Shaul, and W. M. Gelbart. "Defects in Lamellar Phases of Amphiphile-Water Systems." In Correlations and Connectivity, 299–300. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-2157-3_28.

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Robledo, Alberto, and Carmen Varea. "Interfacial Phase Transitions Underlying Amphiphile Micellar Self-Assembly." In Condensed Matter Theories, 595–602. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2934-7_53.

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Sadoc, J. F., and J. Charvolin. "Geometry of Films of Amphiphile Molecules: A Curved Space Approach." In Geometry and Thermodynamics, 73–82. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4615-3816-5_7.

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Conference papers on the topic "Amphiphile"

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Bocker, J., M. Schlenkrich, K. Nicklas, J. Brickmann, and P. Bopp. "Molecular Dynamics Study of the Interface Amphiphile Molecules/Ionic Solution." In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41350.

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Fisusi, Funmilola Adesodun, Omotunde Okubanjo, Kar Wai Chooi, Andreas G. Schatzlein, and Ijeoma F. Uchegbu. "Abstract 5530: Chitosan amphiphile nanoparticles reduced the myelosuppressive effects of lomustine." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5530.

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Han, Sang-Cheol, Kwang-Min Choi, and Sang-Eon Park. "Facile Synthesis of Mesoporous Silica Nanotubes With Amide Type Surfactant." In ASME 2008 2nd Multifunctional Nanocomposites and Nanomaterials International Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/mn2008-47070.

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Novel synthetic method for the formation of mesoporous silica nanotubes was proposed using glycyldodecylamide (GDA) as an amino acid surfactant, which enabled to control the tube diameter, wall structure and morphology with the diverse structures of amphiphile due to the capability of H-bonds by forming amide bond. Moreover, this sol-gel transcription process could be elucidated at neutral condition that enabled the recyclable use of surfactant and resulted in unique structures depending on the temperatures of self-assembly.
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Tajuddin, Hairul Anuar, Tarmezee Idris, Nurul Faiezin Zul, Ahmad Bayhaki Sadidarto, Zanariah Abdullah, and Noraini Ahmad. "Self-aggregation behavior of synthetic amphiphile derived from triazolylbenzoic acid: CMC and phase transition." In ADVANCED MATERIALS FOR SUSTAINABILITY AND GROWTH: Proceedings of the 3rd Advanced Materials Conference 2016 (3rd AMC 2016). Author(s), 2017. http://dx.doi.org/10.1063/1.5010517.

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Ruths, M., S. Lundgren, K. Persson, A. Hillerstro¨m, and K. Boschkova. "Tribological Properties of Associated Structures at Solid–Liquid Interfaces." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-63225.

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We have studied the friction-modifying properties of associated amphiphile structures formed at solid–liquid interfaces from bulk solutions. The mechanisms of friction at the molecular level are only partially understood, but are expected to be strongly affected by the phase state of the confined thin film, i.e., by molecular structure and ordering, and also by interactions between confined molecules and the solid surfaces. In contrast to pre-applied lubricant films, self-assembling systems present the advantage of being self-healing, so that upon local fluctuations in pressure and wear, the film may spontaneously reform.
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Sohn, Youn Soo, Yong Joo Jun, and Hwa Jeong Lee. "Abstract A116: Stable and efficient delivery of docetaxel by micelle encapsulation using a tripodal cyclotriphosphazene amphiphile." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a116.

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Dan, Kaustabh, Madhusudan Roy, and Alokmay Datta. "Detection of a new 'nematic-like' phase in liquid crystal-amphiphile mixture by differential scanning calorimetry." In SOLID STATE PHYSICS: Proceedings of the 58th DAE Solid State Physics Symposium 2013. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4872492.

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John, George, Jose James, Malick Samateh, Siddharth Marwaha, and Vikas Nanda. "Sucralose Hydrogels: Peering into the Reactivity of Sucralose versus Sucrose Using Lipase Catalyzed Trans-Esterification." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/xkza4963.

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Sucralose differs from sucrose only by virtue of having three Cl groups instead of OH groups. Its intriguing features include being noncaloric, noncariogenic, 600 times sweeter than sucrose, stable at high temperatures/acidic pH's, and void of disagreeable aftertastes. These properties are attractive as food additive, one of which is as hydrogel obtainable via the technique of molecular gelation using a sucralose-derived low-molecular weight gelator (LMWG). The process of molecular gelation entails using specially designed lipid-like amphiphilic molecules capable of self-assembling in a liquid solvent to form a 3D-network. A rational molecular design would involve appending lipophilic alkyl chain to sucralose to afford sucralose-based amphiphiles. Our preliminary study has shown that sucralose, unlike sucrose, is unreactive under biocatalytic conditions using lipase enzyme, which is consistent with its reported lack of reactivity by hydrolytic enzymes in the body. Hence, the aim of this work was (i) to use computation and simulations to further understand sucralose's lack of enzymatic reactivity and (ii) to synthesize the sucralose-based amphiphiles using conventional chemical synthesis and systematically study their tendency towards hydrogelation. Three of the sucralose-based amphiphiles (SL-5, SL-6 and SL-7) proved to be successful hydrogelators. The gelators also showed the ability to gel selected beverages. The LMWGs gelled quantities of water and beverage up to 71 and 55 times their weight, respectively, and remain thermally stable up to 144 °C.
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Upamali, Karasinghe A., Chris Britton, Jith Liyanage, Matt Dean, Upali Weerasooriya, and Winoto Winoto. "Tri-methyl-propane and glycerin-based surface-active co-solvents (SAS) as an effective, low-cost, and environmentally friendly source of nonionic/anionic amphiphiles for chemical EOR applications." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/lotm5261.

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This is the first known applications of tri-methyl-propane and glycerin alkoxylates in chemical EOR. Very large molecular weight amphiphile molecules with varying PO/EO units were synthesized for this study. Our systematic experiments demonstrate the breadth of applicability for this novel and highly underutilized class of chemicals in combination with naturally generated soaps in the reservoir. Phase behavior and coreflood experiments with multiple crude oils with significant chemical and geographical diversity are presented as evidence to the efficacy of these chemicals. Triol molecular structure of glycerin can be easily customized with large amount of PO and EO to yield an optimal HLB for a given crude oil. These molecules exhibit favorable characteristics such as high salinity/hardness tolerance, aqueous solubility and flowability for logistical field applications. PO levels above approximately 25 units significantly improved surface activity with medium to heavy crude oils. EO units can be included/increased to improve cloud point for specific reservoir conditions. Remarkably, the optimal salinities of the SP/ACP/ASP formulations were fairly insensitive to co-solvent concentration. Furthermore, these co-solvents were able to be substituted in place of more costly anionic surfactants, with no loss in formulation effectiveness. These chemicals were also effective in improving polymer solution quality, via better filterability and injectivity. These novel co-solvents are effective at low concentrations and can be tailored for many EOR targets
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Dodero, Verónica, Zulma Quirolo, and Alejandra Sequeira. "Synthesis and Characterization of Photomodulable Amphiphiles." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00428.

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Reports on the topic "Amphiphile"

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Thompson, Andre L., Brian J. Love, and Rick D. Davis. Aqueous-based amphiphile solutions used as gel coatings to reduce flammability of cotton fabrics. Gaithersburg, MD: National Institute of Standards and Technology, July 2019. http://dx.doi.org/10.6028/nist.tn.2047.

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Stanic, Vesna, Charlotte Broadbent, Elaine DiMasi, Ramiro Galleguillos, and Valerie Woodward. Micellar Surfactant Association in the Presence of a Glucoside-based Amphiphile Detected via High-Throughput Small Angle X-ray Scattering. Office of Scientific and Technical Information (OSTI), November 2016. http://dx.doi.org/10.2172/1340427.

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Barthelemy, Philippe. Amphiphiles for DNA Supramolecular Assemblies. Fort Belvoir, VA: Defense Technical Information Center, November 2005. http://dx.doi.org/10.21236/ada441262.

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Thayumanavan, Sankaran. Stimuli Responsive Amphiphilic Assemblies. Fort Belvoir, VA: Defense Technical Information Center, November 2013. http://dx.doi.org/10.21236/ada607170.

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Thayumanavan, Sankaran. Amphiphilic Nanocontainers for Binding and Catalysis. Fort Belvoir, VA: Defense Technical Information Center, December 2003. http://dx.doi.org/10.21236/ada424480.

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Glotzer, Sharon C. Final Report for Grant # DE-FG02-02ER46000 Simulations of Self-Assembly of Tethered Nanoparticle Shape Amphiphiles. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1150856.

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Jakhar, Shailja. EXPLORING THE INTERACTION OF AMPHIPHILIC MYCOBACTERIAL LIPOARABINOMANNAN WITH LIPOPROTEINS: IMLICATIONS FOR BLOOD BASED DIAGNOSIS. Office of Scientific and Technical Information (OSTI), May 2021. http://dx.doi.org/10.2172/1784691.

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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist biophores (ii) to develop an arsenal of amphiphilic topically active PK/PBAN antagonists with an array of different time-release profiles based on the previously developed prototype analog; (iii) to develop rationally designed non-peptide SMLs based on the antagonist biophore determined in (i) and evaluate them in cloned receptor microplate binding assays and by pheromonotropic, melanotropic and pupariation in vivo assays. (iv) to clone PK/PBAN receptors (PK/PBAN-Rs) for further understanding of receptor-ligand interactions; (v) to develop microplate binding assays for screening the above SMLs. In the course of the granting period A series of amphiphilic PK/PBAN analogs based on a linear lead antagonist from the previous BARD grant was synthesized that incorporated a diverse array of hydrophobic groups (HR-Suc-A[dF]PRLa). Others were synthesized via the attachment of polyethylene glycol (PEG) polymers. A hydrophobic, biostablePK/PBAN/DH analog DH-2Abf-K prevented the onset of the protective state of diapause in H. zea pupae [EC50=7 pmol/larva] following injection into the preceding larval stage. It effectively induces the crop pest to commit a form of ‘ecological suicide’. Evaluation of a set of amphiphilic PK analogs with a diverse array of hydrophobic groups of the formula HR-Suc-FTPRLa led to the identification of analog T-63 (HR=Decyl) that increased the extent of diapause termination by a factor of 70% when applied topically to newly emerged pupae. Another biostablePK analog PK-Oic-1 featured anti-feedant and aphicidal properties that matched the potency of some commercial aphicides. Native PK showed no significant activity. The aphicidal effects were blocked by a new PEGylated PK antagonist analog PK-dF-PEG4, suggesting that the activity is mediated by a PK/PBAN receptor and therefore indicative of a novel and selective mode-of-action. Using a novel transPro mimetic motif (dihydroimidazole; ‘Jones’) developed in previous BARD-sponsored work, the first antagonist for the diapause hormone (DH), DH-Jo, was developed and shown to block over 50% of H. zea pupal diapause termination activity of native DH. This novel antagonist development strategy may be applicable to other invertebrate and vertebrate hormones that feature a transPro in the active core. The research identifies a critical component of the antagonist biophore for this PK/PBAN receptor subtype, i.e. a trans-oriented Pro. Additional work led to the molecular cloning and functional characterization of the DH receptor from H. zea, allowing for the discovery of three other DH antagonist analogs: Drosophila ETH, a β-AA analog, and a dF analog. The receptor experiments identified an agonist (DH-2Abf-dA) with a maximal response greater than native DH. ‘Deconvolution’ of a rationally-designed nonpeptide heterocyclic combinatorial library with a cyclic bis-guanidino (BG) scaffold led to discovery of several members that elicited activity in a pupariation acceleration assay, and one that also showed activity in an H. zea diapause termination assay, eliciting a maximal response of 90%. Molecular cloning and functional characterization of a CAP2b antidiuretic receptor from the kissing bug (R. prolixus) as well as the first CAP2b and PK receptors from a tick was also achieved. Notably, the PK/PBAN-like receptor from the cattle fever tick is unique among known PK/PBAN and CAP2b receptors in that it can interact with both ligand types, providing further evidence for an evolutionary relationship between these two NP families. In the course of the granting period we also managed to clone the PK/PBAN-R of H. peltigera, to express it and the S. littoralis-R Sf-9 cells and to evaluate their interaction with a variety of PK/PBAN ligands. In addition, three functional microplate assays in a HTS format have been developed: a cell-membrane competitive ligand binding assay; a Ca flux assay and a whole cell cAMP ELISA. The Ca flux assay has been used for receptor characterization due to its extremely high sensitivity. Computer homology studies were carried out to predict both receptor’s SAR and based on this analysis 8 mutants have been generated. The bioavailability of small linear antagonistic peptides has been evaluated and was found to be highly effective as sex pheromone biosynthesis inhibitors. The activity of 11 new amphiphilic analogs has also been evaluated. Unfortunately, due to a problem with the Heliothis moth colony we were unable to select those with pheromonotropic antagonistic activity and further check their bioavailability. Six peptides exhibited some melanotropic antagonistic activity but due to the low inhibitory effect the peptides were not further tested for bioavailability in S. littoralis larvae. Despite the fact that no new antagonistic peptides were discovered in the course of this granting period the results contribute to a better understanding of the interaction of the PK/PBAN family of Nps with their receptors, provided several HT assays for screening of libraries of various origin for presence of PK/PBAN-Ragonists and antagonists and provided important practical information for the further design of new, peptide-based insecticide prototypes aimed at the disruption of key neuroendocrine physiological functions in pest insects.
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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, October 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and pupariation activities; (ii) Test the inhibitory potencies of the BBC compounds on the above activities evoked either by synthetic peptides (PBAN, LPK, myotropin and pheromonotropin) or by the natural endogenous mechanism; (iii) Determine the bioavailability of the most potent BBC compounds that will be found in (ii); (iv) Design, synthesize and examine novel PK/PBAN analogs with enhanced bioavailability and receptor binding; (v) Design and synthesize ‘magic bullet’ analogs and examine their ability to selectively kill cells expressing the PK/PBAN receptor. To achieve these goals the agonistic and antagonistic activities/properties of rationally designed linear and BBC neuropeptide (NP) were thoroughly studied and the information obtained was further used for the design and synthesis of improved compounds toward the design of an insecticide prototype. The study revealed important information on the structure activity relationship (SAR) of agonistic/antagonistic peptides, including definitive identification of the orientation of the Pro residue as trans for agonist activity in 4 PK/PBANbioassays (pheromonotropic, pupariation, melanotropic, & hindgut contractile) and a PK-related CAP₂b bioassay (diuretic); indications that led to the identification of a novel scaffold to develop biostbiostable, bioavailable peptidomimetic PK/PBANagonists/antagonists. The work led to the development of an arsenal of PK/PBAN antagonists with a variety of selectivity profiles; whether between different PKbioassays, or within the same bioassay between different natural elicitors. Examples include selective and non-selective BBC and novel amphiphilic PK pheromonotropic and melanotropic antagonists some of which are capable of penetrating the moth cuticle in efficacious quantities. One of the latter analog group demonstrated unprecedented versatility in its ability to antagonize a broad spectrum of pheromonotropic elicitors. A novel, transPro mimetic motif was proposed & used to develop a strong, selective PK agonist of the melanotropic bioassay in moths. The first antagonist (pure) of PK-related CAP₂b diuresis in flies was developed using a cisPro mimetic motif; an indication that while a transPro orientation is associated with receptor agonism, a cisPro orientation is linked with an antagonist interaction. A novel, biostablePK analog, incorporating β-amino acids at key peptidase-susceptible sites, exhibited in vivo pheromonotropic activity that by far exceeded that of PBAN when applied topically. Direct analysis of neural tissue by state-of-the-art MALDI-TOF/TOF mass spectrometry was used to identify specific PK/PK-related peptides native to eight arthropod pest species [house (M. domestica), stable (S. calcitrans), horn (H. irritans) & flesh (N. bullata) flies; Southern cattle fever tick (B. microplus), European tick (I. ricinus), yellow fever mosquito (A. aegypti), & Southern Green Stink Bug (N. viridula)]; including the unprecedented identification of mass-identical Leu/Ile residues and the first identification of NPs from a tick or the CNS of Hemiptera. Evidence was obtained for the selection of Neb-PK-2 as the primary pupariation factor of the flesh fly (N. bullata) among native PK/PK-related candidates. The peptidomic techniques were also used to map the location of PK/PK-related NP in the nervous system of the model fly D. melanogaster. Knowledge of specific PK sequences can aid in the future design of species specific (or non-specific) NP agonists/antagonists. In addition, the study led to the first cloning of a PK/PBAN receptor from insect larvae (S. littoralis), providing the basis for SAR analysis for the future design of 2ⁿᵈgeneration selective and/or nonselective agonists/antagonists. Development of a microplate ligand binding assay using the PK/PBAN pheromone gland receptor was also carried out. The assay will enable screening, including high throughput, of various libraries (chemical, molecular & natural product) for the discovery of receptor specific agonists/antagonists. In summary, the body of work achieves several key milestones and brings us significantly closer to the development of novel, environmentally friendly pest insect management agents based on insect PK/PBANNPs capable of disrupting critical NP-regulated functions.
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