Dissertations / Theses on the topic 'Amphibian peptides'
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Wegener, Kate Louise. "Amphibian peptides : their structures and bioactivity." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phw4114.pdf.
Full textSalmon, Amanda Lizabeth. "Structural and functional characterisation of bioactive amphibian skin peptides." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247347.
Full textShi, Daning. "Functional studies on the peptides from amphibian skin secretions." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711901.
Full textWang, Ran. "Biological effects of novel amphibian skin peptides and their catabolism." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557850.
Full textGao, Yitian. "Peptidomic and bioinformatic studies on bioactive peptides from amphibian skin secretions." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726351.
Full textLv, Liangchun. "Peptidomic and genomic analyses on bioactive peptides from the amphibian skin." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/peptidomic-and-genomic-analyses-on-bioactive-peptides-from-the-amphibian-skin(ffa8be66-4a1e-404f-b22a-3f6fbb4782b5).html.
Full textZheng, Huiru. "New algorithms for the analysis of mass spectral profiles from amphibian data." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272069.
Full textChia, Brian Cheng San. "Amphibian antimicrobial peptides : their structures and mechanisms of action : a thesis presented for the degree of Doctor of Philosophy." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phc532.pdf.
Full textWabnitz, Paul Andrew. "Chemistry and medical implications of novel amphibian peptides : a thesis submitted for the degree of Doctor of Philosophy /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phw112.pdf.
Full textBrinkworth, Craig Steven. "The primary and secondary structure determination of bioactive amphibian peptides : a thesis submitted for the degree of Doctor of Philosophy." Title page, contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phb8586.pdf.
Full textMcLeod, Janet Leigh, and janet mcleod@deakin edu au. "The natriuretic peptides and their receptors in the brain of the amphibian, Bufo marinus." Deakin University. School of Biological and Chemical Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20071024.112730.
Full textDong, Yanjing. "Identification, molecular cloning and functional characterization of novel bioactive peptides from amphibian skin secretion." Thesis, Queen's University Belfast, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766285.
Full textPower, Gavin Jude. "Isolation, structural characterisation and mechanisms of action of novel insulin-releasing peptides from amphibian skin secretions." Thesis, University of Ulster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554281.
Full textGericke, Maria Catharina. "Aspects of amphibian chytrid infections in South Africa / M.C. Gericke." Thesis, North-West University, 2008. http://hdl.handle.net/10394/3713.
Full textThesis (M. Environmental Science)--North-West University, Potchefstroom Campus, 2009.
O'Rourke, Martin Gerard. "An investigation of the signalling pathways in mammalian tissues stimulated by an adenosine analogue and amphibian derived peptides." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393765.
Full textCosta, André Sónia Maria. "Mécanisme d’action et relation structure-fonction des temporines SH, une famille de peptides antimicrobiens de la peau d’Amphibien." Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066757.
Full textAntimicrobial peptides (AMPs) are key effectors of innate immunity that provide a first line of defense against pathogens. These peptides typically have broad-spectrum antimicrobial activity and act rapidly and efficiently through a membranolytic mechanism that limits the development of resistance. With the emergence of resistant microorganisms, a major public health concern, AMPs therefore represent good candidates for the therapeutic development of new and valuable compounds. During my thesis, I focused on AMP from amphibian skin. Firstly, five potential AMP precursors were identified from the frog Trachycephalus resinifictrix using a combined biochemical /molecular biology approach. Among these, two correspond to cathelicidin precursors, two were similar to the “AMP/opioid“ precursors (T. venulosus), and one was similar to hylareleasin precursors (Hyla simplex). Secondly, I was interested in temporins SH, small AMPs previously isolated from the frog Pelophylax saharicus by our team. We performed structure-activity relationship studies on temporin-SHf, the smallest linear amphibian AMP known to date (8 residues). This allowed us to identify several potent analogs with a higher therapeutic index. Furthermore, we also thoroughly studied the mechanism of action of temporin-SHa and its analogs. We showed that temporins act rapidly through a membranolytic mechanism, leading to bacterial membrane disruption (detergent-like effect). For Leishmania promastigotes, the same membranolytic mechanism was observed with also a temporin-induced apoptosis that takes place at higher peptide concentrations. Finally, biophysical and biological techniques enabled us to structurally and functionally characterize temporin-SHe. Like temporin-SHa, this peptide displayed a broad-spectrum activity including Leishmania. Our results indicate that temporins could serve as lead compounds to develop a new class of therapeutic anti-infective peptides
Burkart, David. "UNDERSTANDING CHYTRIDIOMYCOSIS RESISTANCE BY INVESTIGATING THE CUTANEOUS DEFENSE MECHANISMS OF MARSUPIAL FROGS." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1835.
Full textKrynak, Katherine L. "ENVIRONMENTAL INFLUENCES ONAMPHIBIAN INNATE IMMUNE DEFENSE TRAITS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1435590530.
Full textMarenah, Lamin. "Novel peptide discovery : isolation and characterisation of peptides with antidiabetic properties from the skin secretions of amphibians." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274394.
Full textCondamine, Eric. "Etudes pharmacologiques et structurales des peptides E bovin et amphibien, dérivés de la proenképhaline A." Rouen, 1999. http://www.theses.fr/1999ROUES020.
Full textHouston, Rebecca. "Cell biological studies on a novel amphibian derived peptide analogue." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.676522.
Full textRaja, Zahid. "Caractérisation fonctionnelle de peptides antimicrobiens de peau d'amphibien." Paris 6, 2013. http://www.theses.fr/2013PA066829.
Full textPan, Hao. "Studies on novel bioactive peptides from the skin secretion of amphibians." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709692.
Full textHou, Xiaojuan. "Identification and molecular cloning of skin secretion peptides from selected Eurasian amphibians." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680080.
Full textVanhoye, Damien. "Analyse évolutive, moléculaire et fonctionnelle des peptides antimicrobiens des amphibiens." Paris 6, 2004. http://www.theses.fr/2004PA066326.
Full textFarragher, Susan. "Study of peptide transcripts in the skin and stimulated skin secretions of three different species of amphibians." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232839.
Full textChen, Dong. "Identification, molecular cloning and functional characterisation of novel bioactive peptide drugs from amphibian skin secretions." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/identification-molecular-cloning-and-functional-characterisation-of-novel-bioactive-peptide-drugs-from-amphibian-skin-secretions(a5d6ffd1-1440-4528-af7a-4f6d9e244f76).html.
Full textSteinborner, Simon Todd. "The observation of evolutionary trends in amphibians and the analysis of negative ion fragmentations in large peptide systems by mass spectrometry /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs819.pdf.
Full textAmiche, Mohamed. "Les Peptides opioïdes de la peau d'amphibiens : la dermophine et la dermenkephaline : études structurales et pharmacologique." Paris 6, 1990. http://www.theses.fr/1990PA066017.
Full textNetchitailo, Pierre. "La corticostéroïdogénèse chez un amphibien anoure : mécanismes intracellulaires et contrôle multifactoriel." Rouen, 1987. http://www.theses.fr/1987ROUES037.
Full textAbbassi, Feten. "Caractérisation structurale et fonctionnelle des temporines-SH : de nouveaux peptides antimicrobiens isolés chez l'espèce de grenouille nord-africaine Pelophylax saharica." Paris 6, 2009. http://www.theses.fr/2009PA066702.
Full textLeboulenger, François. "Contribution à l'étude de l'activité de la corticosurrénale des amphibiens anoures, une glande endocrine sous contrôle multifactoriel." Rouen, 1986. http://www.theses.fr/1986ROUES027.
Full textRudolf, Étienne. "Expression, purification et caractérisation biochimique partielle de la peptidase-1 marqueur du sexe génotypique chez pleurodèles waltl (amphibien urodèle)." Nancy 1, 1995. http://www.theses.fr/1995NAN10393.
Full textGalanth, Cécile. "Etude du mécanisme d'action d'une peptide cationique antibactérien, la dermaseptine B2." Paris 6, 2009. http://www.theses.fr/2009PA066047.
Full textAlmeida, Richardson Alves de. "Peptídeos antimicrobianos de Hypsiboas cinerascens (Spix, 1824)." Universidade Federal do Amazonas, 2011. http://tede.ufam.edu.br/handle/handle/4452.
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Amphibian skin secretions are rich sources of biologically active substances with various physiological functions and defense, most of low molecular weight, as biogenic amines, alkaloids, steroids, peptides and proteins of high molecular weight. The genus Hypsiboas, belonging to the family Hylidae from class of amphibians, presents as promissing supplier of peptides with biological potential. Peptides identified of species Hypsiboas are analogous to the known antimicrobial peptides. This work was realized a systematic study of the skin secretion of Hypsiboas cinerascens obtained by stimulation, where it was possible to identify a new peptide with wide antimicrobial activity, named cinerascetina. Its sequence was identified by techniques of high performance liquid chromatography (HPLC) and mass spectrometry (MALDI-TOFTOF) and confirmed by genetic sequencing, and was also possible identified six new peptides with possible antimicrobial activity.
Secreções de pele de anfíbios são fontes ricas de substâncias biologicamente ativas com diversas funções fisiológicas e de defesa, a maioria de baixa massa molecular como as aminas biogênicas, alcaloides, esteroides, peptídeos e proteínas de massa molecular elevada. O gênero Hypsiboas, pertencente à família Hylidae da classe dos anfíbios, apresenta-se como promissor fornecedor de peptídeos com potencial biológico. Peptídeos identificados de espécies de Hypsiboas apresentaram analógia a peptídeos antimicrobianos conhecidos. Neste trabalho foi realizado um estudo sistemático da secreção da cutânea de Hypsiboas cinerascens obtida por estimulação, onde foi possível identificar um novo peptídeo com ampla atividade antimicrobiana, o qual foi denominado de Cinerascetina. Sua sequência foi identificada por técnicas de cromatografia liquida de alta eficiência (CLAE) e espectrometria de massa (MALDITOF- TOF) e confirmada por técnica de sequenciamento genético, sendo que através desse estudo de sequenciamento genético, também foi possível identificar seis novos peptídeos com possível atividade antimicrobiana.
Pinto, Erika Gracielle. "Isolamento, caracterização e atividade anti-leishmania chagasi e anti-trypanosoma cruzi de compostos bioativos de venenos de anfíbios brasileiros." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-31012014-154317/.
Full textAmong the tropical parasitic diseases, those caused by protozoa present a major challenge to public health, being represented by leishmaniasis and Chagas disease. Affect large populations marginal to the global economic process, and thus are not seen as potential markets. This project aimed the isolation of new natural compounds in animal venoms with anti-Leishmania activity and anti-T. cruzi. The present study fractionated by different chromatographic techniques, the poisons of the amphibians Siphonops annulatus, Corythomantis greeningi, Aparasphenodon brunoi and Phyllomedusa hypochondrialis, aiming the isolation of peptides and secondary metabolites through bioguided assays. By using mass spectrometry and sequencing by Edman degradation, it was possible to do the biochemical characterization of five active peptides from the poison of Phyllomedusa hypochondrialis, as bradykinin, dermaseptins 1 and 4 and phylloseptins 7 and 8. The peptides showed a 50% Effective Concentration (EC50) ranging from 0.7 to 20 ?g/mL in L. (L.) infantum chagasi and T. cruzi, with little or no cytotoxicity to mammalian cells at the tested concentrations. In addition, the chemical separation of the poison of the amphibian Siphonops annulatus provided a highly active fraction against promastigotes of L. (L.) infantum chagasi, with an EC50 of 0.065 ?g/mL, but highly toxicity to peritoneal macrophages and without selectivity against the intracellular forms of Leishmania. Ultrastructural studies of Leishmania showed severe mitochondrial damages and the formation of large cytoplasmic vacuoles, leading to parasite death within few hours. The present study demonstrated the potential of peptides and secondary metabolites of amphibian poisons, and if adequately studied, may contribute as prototypes of new drugs for neglected diseases.
Maselli, Vita Marie. "Amphibian neuropeptides : isolation, sequence determination and bioactivity." 2006. http://hdl.handle.net/2440/37864.
Full textThesis (Ph.D.)--School of Chemistry and Physics, 2006.
Apponyi, Margit Anneliese. "Amphibian skin peptides which inhibit nNOS : structure and binding studies using heteronuclear NMR." 2006. http://hdl.handle.net/2440/37795.
Full textThesis (Ph.D.)--School of Chemistry and Physics, 2006.
Brinkworth, Craig Steven. "The primary and secondary structure determination of bioactive amphibian peptides." Thesis, 2003. http://hdl.handle.net/2440/80313.
Full textThesis (Ph.D.) -- University of Adelaide, Dept. of Chemistry, 2003
Apponyi, Margit Anneliese. "Amphibian skin peptides which inhibit nNOS : structure and binding studies using heteronuclear NMR." Thesis, 2006. http://hdl.handle.net/2440/37795.
Full textThesis (Ph.D.)--School of Chemistry and Physics, 2006.
Chia, Brian Cheng San. "Amphibian antimicrobial peptides : their structures and mechanisms of action / by Brian Cheng San Chia." Thesis, 2000. http://hdl.handle.net/2440/19636.
Full textBibliography: leaves 183-220.
xiii, 226 leaves : ill. (chiefly col.) ; 30 cm.
Three antimicrobial peptides, maculatin 1.1, uperin 3.6 and caerin 4.1 have been isolated from the respective skin glands of the Australian amphibians Litoria genimaculata, Uperoleia mjobergii and Litoria caerulea. To gain a deeper insight into their mechanisms of action, three dimensional structural studies have been conducted using circular dichroism, two-dimensional nuclear resonance and computer modelling techniques. The role of central flexibility within antibiotic peptides in their interaction with bacterial membranes is also discussed.
Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2000
Calabrese, Antonio Nickolas. "Characterisation of protein structure and interactions: novel applications to the study of bioactive peptides." Thesis, 2013. http://hdl.handle.net/2440/82148.
Full textThesis (Ph.D.)--University of Adelaide, School of Chemistry and Physics, 2013.
Wabnitz, Paul Andrew. "Chemistry and medical implications of novel amphibian peptides : a thesis submitted for the degree of Doctor of Philosophy / by Paul Andrew Wabnitz." Thesis, 1999. http://hdl.handle.net/2440/19494.
Full textIncludes bibliographical references.
xv, 210 leaves : ill. ; 30 cm.
A chemical and pharmacological investigation of compounds derived from amphibian skin. Isolates novel amphibian peptides and further investigates the biological activity of some of the peptides discovered.
Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2000
Moreira, Anabela Durães de Sousa. "Two birds, one study: evaluating the therapeutic potential of amphibian ocellatin-PT4 and -PT9 peptides for application in leishmaniasis and neuroinflammation-related diseases." Master's thesis, 2019. https://hdl.handle.net/10216/123262.
Full textMoreira, Anabela Durães de Sousa. "Two birds, one study: evaluating the therapeutic potential of amphibian ocellatin-PT4 and -PT9 peptides for application in leishmaniasis and neuroinflammation-related diseases." Dissertação, 2019. https://hdl.handle.net/10216/123262.
Full textJackway, Rebecca Jo. "Biologically active peptides from Australian amphibians." Thesis, 2008. http://hdl.handle.net/2440/62877.
Full textThesis (Ph.D.) -- University of Adelaide, School of Chemistry and Physics, 2008
Fu, Hung-Jiang, and 傅宏江. "The structure-specificity relationship study of amphibian peptide pheromones." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/79186566391922948853.
Full text朝陽科技大學
應用化學系碩士班
100
Three female newt attracting decapeptide pheromones-sodefrin, silefrin and V8-sodefrin, demonstrate significant difference in their species-specificity. We investigated the conformation of the three peptide pheromones under different environments through circular dichroism, nuclear magnetic resonance and molecular modeling. It was found that three peptides exist mainly as random coils in aqueous solution, with introduction of SDS micelle, a stabe turn-like conformation can be observed in fragments of Ile2~Lys5 and Asp6~Lys10 in silefrin, and in fragments of Lys5~Leu8 and Asp6~Leu9 in both sodefrin and its analogue V8-sodefrin. It is also found that the conformation of V8-sodefrin is more flexible than that of native sodefrin. Our results suggest that the species-specificity of the newt peptide pheromones may be triggered by their structural variations.
ARRULO, Miriam Raquel Figueiredo. "Antibacterial, antiparasitic and anticancer properties of host-defence peptides from argentinian amphibians." Master's thesis, 2019. http://hdl.handle.net/10362/116369.
Full textHost-defence peptides (HDPs) are usually short, cationic and amphipathic molecules that are part of the innate immune system of most multicellular organisms. Initially described as antimicrobial peptides (AMPs) due to their interaction and destruction of bacterial cell walls which are naturally anionic, however, recent studies have shown that HDPs have a broader range of action being able to interact with cancer cells and may therefore also be referred to as anticancer peptides (ACPs). Increasing worldwide multidrug resistance (MDR) together with the low discovery rate of new drugs and the fact that the current treatments used in the therapy of various diseases can be very harsh and damaging to human beings, culminated in an urgent need to study new alternatives such as HDPs. Several species of Patagonian amphibians have adapted to survive in adverse climatic conditions, inhabiting arid or semi-arid zones of Patagonia. The skin of these amphibians produces a protective secretion from which the HDPs were extracted, identified and synthesized into peptides PSo-4, PSo-7, PSo2-2, Thau-3 and Ooc-1. The aim of this work was to characterize the antimicrobial and anticancer properties of the peptides mentioned as well as their structure in solution and in the presence of lipid vesicles. Antimicrobial activity and interaction with bacterial membranes were assessed in Gram-positive and Gram-negative bacteria by minimal inhibitory concentration determination and atomic force microscopy. In addition, antiparasitic assays were carried out on wild-type bloodstream forms of Trypanosoma brucei brucei while anticancer studies were performed on human hepatocellular carcinoma Huh-7 cells through fluorescence and absorption spectrophotometry methods respectively. The characterization of the peptides conformation when in aqueous medium or in a solution containing POPC:POPG lipid vesicles was done via spectrofluorometric and circular dichroism assays PSo-4, PSo-7, Thau-3 and Ooc-1 exhibited antimicrobial activity but only against the Gram-positive bacteria E. coli. PSo-4 showed the strongest activity while Ooc-1 proved to be bactericidal. Analysis by AFM supports the hypothesis that the action of these peptides may occur either at the bacterial cell wall level or by potentially interfering with intracellular pathways or targets, culminating in cell disintegration. Preliminary results also indicate that peptide Ooc-1 exerts inhibitory effects on the parasite T. brucei brucei. Furthermore, peptides PSo-7, PSo-4, and PSo2-2 revealed deleterious capacity against Huh-7 cells. Structurally most peptides exhibited a propensity for aggregation, when in solution, and presented a secondary structure with some α-helix content, except for PSo-7 and PSo-4 that maintained a random coil arrangement and lower aggregation levels. Considering the behaviour and scope of action demonstrated, we believe these peptides to be worthy candidates for further investigation and possible sequence manipulation to enhance their demonstrated capabilities in order to open the path of pharmacological viability.
Pukala, Tara Louise. "Structural and mechanistic studies of bioactive peptides." 2006. http://hdl.handle.net/2440/37851.
Full textThesis (Ph.D.) -- University of Adelaide, School of Chemistry and Physics, Discipline of Chemistry, 2006
Steinborner, Simon Todd. "The observation of evolutionary trends in amphibians and the analysis of negative ion fragmentations in large peptide systems by mass spectrometry / by Simon Todd Steinborner." Thesis, 1997. http://hdl.handle.net/2440/19030.
Full textThe aim of this research is to observe the evolutionary relationships within and between frog species, as well as to discover potentially useful medicinal peptides. The two main areas of research of this thesis are the characterisation of peptides from frogs belonging to the genus Litoria and the analysis of negative ion fragmentations from large peptides.
Thesis (Ph.D.) -- University of Adelaide, Dept. of Chemistry, 1997?