Relevant bibliographies by topics / Aminobenzimidazoles

Academic literature on the topic 'Aminobenzimidazoles'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Aminobenzimidazoles.'

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Journal articles on the topic "Aminobenzimidazoles"

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Zellmann, Felix, Laura Thomas, Ute Scheffer, Roland Hartmann, and Michael Göbel. "Site-Specific Cleavage of RNAs Derived from the PIM1 3′-UTR by a Metal-Free Artificial Ribonuclease." Molecules 24, no. 4 (February 23, 2019): 807. http://dx.doi.org/10.3390/molecules24040807.

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Oligonucleotide conjugates of tris(2-aminobenzimidazole) have been reported previously to cleave complementary RNA strands with high levels of sequence and site specificity. The RNA substrates used in these studies were oligonucleotides not longer than 29-mers. Here we show that ~150–400-mer model transcripts derived from the 3′-untranslated region of the PIM1 mRNA reacted with rates and specificities comparable to those of short oligonucleotide substrates. The replacement of DNA by DNA/LNA mixmers further increased the cleavage rate. Tris(2-aminobenzimidazoles) were designed to interact with phosphates and phosphate esters. A cell, however, contains large amounts of phosphorylated species that may cause competitive inhibition of RNA cleavage. It is thus important to note that no loss in reaction rates was observed in phosphate buffer. This opens the way to in-cell applications for this type of artificial nuclease. Furthermore, we disclose a new synthetic method giving access to tris(2-aminobenzimidazoles) in multigram amounts.
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Mumtaz, Mubeen, Nasir Rasool, Gulraiz Ahmad, Naveen Kosar, and Umer Rashid. "N-Arylation of Protected and Unprotected 5-Bromo-2-aminobenzimidazole as Organic Material: Non-Linear Optical (NLO) Properties and Structural Feature Determination through Computational Approach." Molecules 26, no. 22 (November 17, 2021): 6920. http://dx.doi.org/10.3390/molecules26226920.

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The interest in the NLO response of organic compounds is growing rapidly, due to the ease of synthesis, availability, and low loss. Here, in this study, Cu(II)-catalyzed selective N-arylation of 2-aminobenzimidazoles derivatives were achieved in the presence of different bases Et3N/TMEDA, solvents DCM/MeOH/H2O, and various aryl boronic acids under open atmospheric conditions. Two different copper-catalyzed pathways were selected for N-arylation in the presence of active nucleophilic sites, providing a unique tool for the preparation of NLO materials, C-NH (aryl) derivatives of 2-aminobenzimidazoles with protection and without protection of NH2 group. In addition to NMR analysis, all synthesized derivatives (1a–1f and 2a–2f) of 5-bromo-2-aminobenzimidazole (1) were computed for their non-linear optical (NLO) properties and reactivity descriptor parameters. Frontier molecular orbital (FMO) analysis was performed to get information about the electronic properties and reactivity of synthesized compounds.
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Danneberg, Friederike, Alice Ghidini, Plamena Dogandzhiyski, Elisabeth Kalden, Roger Strömberg, and Michael W. Göbel. "Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)." Beilstein Journal of Organic Chemistry 11 (April 16, 2015): 493–98. http://dx.doi.org/10.3762/bjoc.11.55.

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Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation occurs with similar rates and substrate specificities as in experiments with DNA conjugates we performed earlier. Although aggregation phenomena are observed in some cases, proper substrate recognition is not compromised. While our previous synthesis of 2-aminobenzimidazoles required an HgO induced cyclization step, a mercury free variant is described herein.
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Nájera, Carmen, José Miguel Sansano, and Enrique Gómez-Bengoa. "Heterocycle-based bifunctional organocatalysts in asymmetric synthesis." Pure and Applied Chemistry 88, no. 6 (June 1, 2016): 561–78. http://dx.doi.org/10.1515/pac-2016-0403.

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AbstractDifferent chiral bifunctional organocatalysts derived from trans-cyclohexane-1,2-diamine bearing different types of guanidine units able to form-hydrogen bonding activation have been designed. Conformational rigid 2-aminobenzimidazoles bearing a tertiary amino group have been used in enantioselective Michael type reactions of activated methylene compounds to nitroalkenes. The C2 symmetric bis(2-aminobenzimidazole) derivatives the appropriate organocatalyst for the conjugate addition of 1,3-dicarbonyl compounds to maleimides as well as for the SN1 reaction of benzylic alcohols with carbon nucleophiles. 2-Aminobenzimidazoles bearing a primary amino group have shown excellent catalytic activity in the Michael reaction of aldehydes to maleimides and nitroalkenes. Diastereomeric 2-aminopyrimidines bearing a prolinamide unit have been incorporated in the trans-cyclohexane-1,2-diamine scaffold and have been used for the inter- and intra-molecular direct aldol reaction under solvent-free conditions. For the Michael reaction of aldehydes with maleimides the primary amine 2-aminopyrimidine has shown excellent efficiency as organocatalyst. The bifunctional character of these organocatalysts has been demonstrated by means of DFT calculations.
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Milata, Viktor. "Nitro and aminobenzimidazoles." Acta Chimica Slovaca 11, no. 2 (October 1, 2018): 182–88. http://dx.doi.org/10.2478/acs-2018-0026.

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AbstractA summary of the preparation methods of 2 tautomeric and 4N-methylated benzimidazoles with a nitro group on the benzene ring (1–6) and with an amino group in the same positions (7–12) were summarized. Annular tautomerism of the title compounds1–12has been studied using1H,13C and15N NMR spectra in liquid and solid state (CPMAS), UV spectra and quantum chemical calculations.
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Gondal, Humaira Y., H. Mashooda, and Muhammad Ali. "New Antibacterial Peptide Analogs of 5-Aminobenzimidazoles." Journal of the Korean Chemical Society 55, no. 4 (August 20, 2011): 650–55. http://dx.doi.org/10.5012/jkcs.2011.55.4.650.

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Kumar, K. Anil, Prakash Kannaboina, D. Nageswar Rao, and Parthasarathi Das. "Nickel-catalyzed Chan–Lam cross-coupling: chemoselective N-arylation of 2-aminobenzimidazoles." Organic & Biomolecular Chemistry 14, no. 38 (2016): 8989–97. http://dx.doi.org/10.1039/c6ob01307d.

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Huang, Kuo-Ting, and Chung-Ming Sun. "Liquid-Phase combinatorial synthesis of aminobenzimidazoles." Bioorganic & Medicinal Chemistry Letters 12, no. 7 (April 2002): 1001–3. http://dx.doi.org/10.1016/s0960-894x(02)00091-4.

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Dyablo, O. V., A. F. Pozharskii, and N. N. Shkurupii. "Some properties of 1-(nitrophenyl)-aminobenzimidazoles." Chemistry of Heterocyclic Compounds 36, no. 1 (January 2000): 37–39. http://dx.doi.org/10.1007/bf02256841.

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Clark, Peter R., Glynn D. Williams, and Nicholas C. O. Tomkinson. "Copper-catalysed C–H functionalisation gives access to 2-aminobenzimidazoles." Organic & Biomolecular Chemistry 17, no. 34 (2019): 7943–55. http://dx.doi.org/10.1039/c9ob01651a.

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Dissertations / Theses on the topic "Aminobenzimidazoles"

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Ishak, Dridi Islem. "Synthèse stéréosélective et réactivité des 4-hydroxy-1-boryl-1-allénylsilanes. Synthèse et étude théorique de nouveaux dérivés de dimères benzimidazolo-1,3,5,2-triazaphosphorine-2-oxydes." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS573.pdf.

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Cette thèse a portée sur deux sujets différents. D’abord la synthèse des 1-silylalléneboranes a été étudiée, pour la première fois, à partir d’époxyde acétylénique et d’un silylborane. Cette méthode permet la préparation stéréosélective et stéréospécifique des allénylboranes via un mécanisme SNi anti. Par la suite, la propargylation des aldéhydes par l’intermédiaire de ces allènes a permis d’accéder de façon stéréosélective aux 2-alcynyldiols-1,3 correspondants. Un état de transition fermé à six chainants a été proposé pour cette dernière transformation qui procède via un mécanisme SE2’. L’étendu et les limites de ces deux réactions ont été explorés. Finalement, la réactivité électrophile et nucléophile des imidates issus de la condensation de 2-aminobenzimidazole sur une variété d’orthoesters a été étudiée comme voie de préparation des dimères N-benzimidazoliques. Nous avons également étudié la synthèse des dimères [1,2a]benzimidazolo-1,3,5,2-triazaphosphorine-2-oxydes via l’action d’hexaméthylphosphoramide sur les dimères N-benzimidazoliques, l’évaluation de l’activité anti-oxydante de ces nouveaux composés formés (dimères amidiniques et phosphoazotés) est en cours
This thesis has focused on two different topics. Firstly, the synthesis of 1-silylalleneborane was studied, for the first time, from acetylenic epoxide and a silylborane. This method allows the stereoselective and stereospecific preparation of allenylboranes through an anti SNi mechanism. Subsequently, propargylation of the aldehydes using allenes afforded stereoselective access to the corresponding 2-alkynyldiols-1,3. A six-member closed transition state has been proposed for this last transformation which proceeds via a SE2' type mechanism. The scope and limitations of these two reactions have been explored.Finally, the electrophilic and nucleophilic reactivity of imidates resulting from the condensation of 2-aminobenzimidazole on a variety of orthoesters was studied as a route for the preparation of N-benzimidazole dimers. We also studied the synthesis of [1,2a] benzimidazolo-1,3,5,2-triazaphosphorin-2-oxide dimers through the action of hexamethylphosphoramide on N-benzimidazole dimers, the evaluation of the antioxidant activity of these new compounds formed (amidic and phospho-nitrogen dimers) is in progress
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Peter, Sascha [Verfasser]. "Künstliche Ribonucleasen auf Basis von 2-Aminobenzimidazolen / von Sascha Peter." 2007. http://d-nb.info/984497927/34.

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Book chapters on the topic "Aminobenzimidazoles"

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Gelmont, Mark. "Preparation of 1,4-bis(5-aminobenzimidazol-2-yl)benzene – monomer for polyamidobenzimidazole polymers and fibers." In 19th International Congress on Heterocyclic Chemistry, 158. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50150-7.

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