Academic literature on the topic 'Amidation reactions'

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Journal articles on the topic "Amidation reactions"

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Liu, Yunyun, and Baoli Zhao. "Step-Economical C–H Activation Reactions Directed by In Situ Amidation." Synthesis 52, no. 21 (2020): 3211–18. http://dx.doi.org/10.1055/s-0040-1707124.

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Owing to the inherent ability of amides to chelate transition-metal catalysts, amide-directed C–H activation reactions constitute a major tactic in directed C–H activation reactions. While the conventional procedures for these reactions usually involve prior preparation and purification of amide substrates before the C–H activation, the step economy is actually undermined by the operation of installing the directing group (DG) and related substrate purification. In this context, directed C–H activation via in situ amidation of the crude material provides a new protocol that can significantly e
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Gao, Yunling. "A new specific mechanism for thioacid/azide amidation: electronic and solvent effects." Open Chemistry 8, no. 2 (2010): 308–19. http://dx.doi.org/10.2478/s11532-009-0139-3.

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AbstractDetailed theoretical studies of azide/thioacid amidation are performed using density functional theory. The calculated results indicate that electronic properties of azide have significant effects on reaction pathways, which result in two distinct mechanisms for electron-rich and electron-poor azide coupling in the base-promoted amidation. For electron-rich azide amidation, after the concerted [3+2] cycloaddition of azide/thiocarboxylate, a new reaction channel is found challenging that recently mentioned, which follows two consecutive, unimolecular reactions with very low activation b
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Harahap, Chiko, Tuti Wukirsari, Sri Handayani, and Sumi Hudiyono PWS. "Comparison of the Lipoamide Synthesis by Direct Amidation and via Amidation of Fatty Acid Methyl Esters." Jurnal Kimia Sains dan Aplikasi 27, no. 7 (2024): 328–35. http://dx.doi.org/10.14710/jksa.27.7.328-335.

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In this research, the preparation of lipoamide through direct amidation of fatty acid and via amidation of fatty acid methyl ester (FAME) was compared. The reactivity of aromatic amines and cyclohexylamine for the synthesis of lipoamide was investigated in this research. The performance of saturated and unsaturated fatty acids was also compared. The synthesis of lipoamides via direct amidation was conducted under reflux using a Dean-Stark trap and silica gel as the catalyst. On the other hand, the amidation of FAME was carried out without catalysts and solvent. Both reactions were run simultan
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Zhao, Bei, Yang Xiao, Dan Yuan, Chengrong Lu, and Yingming Yao. "Synthesis and characterization of bridged bis(amidato) rare earth metal amides and their applications in C–N bond formation reactions." Dalton Transactions 45, no. 9 (2016): 3880–87. http://dx.doi.org/10.1039/c5dt04217h.

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Eight bis(amidato) rare-earth metal amides were successfully synthesized and well characterized, which exhibited high catalytic activities in both the direct amidation of aldehydes and the addition of amines with carbodiimine.
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Kasprzak, Artur, Agnieszka Zuchowska, and Magdalena Poplawska. "Functionalization of graphene: does the organic chemistry matter?" Beilstein Journal of Organic Chemistry 14 (August 2, 2018): 2018–26. http://dx.doi.org/10.3762/bjoc.14.177.

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Reactions applying amidation- or esterification-type processes and diazonium salts chemistry constitute the most commonly applied synthetic approaches for the modification of graphene-family materials. This work presents a critical assessment of the amidation and esterification methodologies reported in the recent literature, as well as a discussion of the reactions that apply diazonium salts. Common misunderstandings from the reported covalent functionalization methods are discussed, and a direct link between the reaction mechanisms and the basic principles of organic chemistry is taken into
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Santos, A. Sofia, Artur M. S. Silva, and M. Manuel B. Marques. "Sustainable Amidation Reactions - Recent Advances." European Journal of Organic Chemistry 2020, no. 17 (2020): 2501–16. http://dx.doi.org/10.1002/ejoc.202000106.

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Mirzoyeva, G. A., and Sh M. Eyvazova. "Study of the amidation reaction of carboxylic acids and their derivatives." World OF PETROLEUM PRODUCTS 2 (2024): 36–47. http://dx.doi.org/10.32758/2782-3040-2024-0-2-36-47.

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The presented work shows the results of research in the field of studying the amidation reaction of carboxylic acids and their functionally substituted derivatives with various amines. The main patterns of the above reaction are shown, the mechanisms of reactions involving carboxylic acids, as well as their derivatives (esters, anhydrides and acid chlorides) are presented. The main areas of application of the synthesized amide products are considered. It is reported that the reaction of direct amidation of carboxylic acids with amine components can occur in the presence of various catalysts or
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Ji, Chong-Lei, Pei-Pei Xie, and Xin Hong. "Computational Study of Mechanism and Thermodynamics of Ni/IPr-Catalyzed Amidation of Esters." Molecules 23, no. 10 (2018): 2681. http://dx.doi.org/10.3390/molecules23102681.

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Nickel catalysis has shown remarkable potential in amide C–N bond activation and functionalization. Particularly for the transformation between ester and amide, nickel catalysis has realized both the forward (ester to amide) and reverse (amide to ester) reactions, allowing a powerful approach for the ester and amide synthesis. Based on density functional theory (DFT) calculations, we explored the mechanism and thermodynamics of Ni/IPr-catalyzed amidation with both aromatic and aliphatic esters. The reaction follows the general cross-coupling mechanism, involving sequential oxidative addition,
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Szwedo, Peter, Travis Jumper, Karie Sanford, et al. "Dehydrogenative Conversions of Aldehydes and Amines to Amides Catalyzed by a Nickel(II) Pincer Complex." Catalysts 13, no. 11 (2023): 1423. http://dx.doi.org/10.3390/catal13111423.

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A C-N cross-coupling approach involving oxidative amidations of aromatic aldehydes in the presence of an amide-based nickel(II) pincer catalyst (2) is demonstrated. Upon optimization, quick reaction times (15 min) and an ideal temperature (25 °C) were established and implemented for the conversion of 33 different amide products using only 0.2 mol% of catalyst. Moderate to good turnover numbers (TONs) were obtained for secondary benzamide products, and moderate TONs were obtained for tertiary benzamide products, with the highest turnover number calculated for the 4-chloro-N-(3-phenylpropyl)benz
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Morteza, Shiri, Notash Behrouz, Zamanian Fatemeh, Yasaei Zahra, and Ranjbar Maryam. "Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides." Organic and Biomolecular Chemistry 15, no. 47 (2017): 10073–81. https://doi.org/10.1039/c7ob02043k.

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A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pdcatalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C–C, C–N, and C–O bonds in a one-pot procedure.
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Dissertations / Theses on the topic "Amidation reactions"

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Lanigan, R. M. "B(OCH2CF3)3-mediated amidation reactions." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433546/.

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This thesis describes the further development of a borate ester, B(OCH2CF3)3, as a reagent for amidation with a focus on carboxylic acids, including N-protected amino acids, and on the amidation of unprotected amino acids. In addition, a novel methodology for the determination of enantiomeric ratio in chiral amines is reported. The B(OCH2CF3)3-mediated direct amidation of carboxylic acids furnishes the amide product in generally excellent yield (A). A formylation method using DMF as the formyl donor was also developed (B). The B(OCH2CF3)3-mediated amidation method allows the amidation of α-chi
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Karaluka, Valerija. "Study and development of boron-mediated amidation reactions." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1571141/.

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This thesis discusses the study and further developments of boron-mediated amidation reactions. Chapter I introduces the conventional and recent methods and developments for the direct amidation of carboxylic acids and their derivatives. An overview of boron-mediated transformations is also given with the focus on stoichiometric methods and boronic acid catalysts. Chapter II describes the utilisation of B(OCH2CF3)3 in the synthesis of medicinally-relevant amides, selective monoacylation of symmetrical diamines, and amidation of unprotected amino acids. Design of Experiments (DoE) is applied as
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MORANDINI, ANDREA. "SYNTHESIS AND USE OF TRIAZINYL QACs AS ANTIMICROBIAL AGENTS." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2988358.

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L’aumento dello sviluppo di microorganismi in grado di resistere alle più comuni sostanze antimicrobiche negli ultimi anni è un fenomeno che da tempo preoccupa le varie organizzazioni della salute mondiale. Lo sviluppo della resistenza alle sostanze avverse è un meccanismo naturale, che i microorganismi hanno sfruttato fin dall’antichità. Con l’avvio verso l’industrializzazione ai primi del XX secolo e la scoperta di potenti farmaci antibiotici, l’umanità ha potuto notevolmente migliorare il suo stile di vita. Il risultato di decenni di utilizzo irresponsabile e sperpero nell’ambiente di quest
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Giguère-Bisson, Maxime. "Investigation of transition metal-catalyzed oxidative amidation of aldehydes and aldehyde-alkyne-amine coupling reactions." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103659.

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This thesis describes the investigation of various amino acids derivatives as reagents for copper-catalyzed, silver-catalyzed and iron-catalyzed reactions and the investigation of an enantioselective cobalt-catalyzed aldehyde-alkyne-amine (A3) coupling reaction. The first part focuses on the large-scale optimization of the oxidative amidation of aldehydes in the presence of amine hydrochloride salts as well as our effort to enhance the reaction scope by the use of amino acids derivatives and short peptides. This is then followed by the development of an enantioselective cobalt-catalyzed A3-cou
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AGOSTINIS, LODOVICO. "Study of 1,3,5-triazine-based amidation agents and their application in condensation reactions, collagen cross-linking and polymer grafting." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2962374.

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Amide bonds are important for the synthesis or functionalization of many biological macromolecules and a wide range of pharmaceutical products, polymers and fibers. 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM) is an unexploited amidation agent capable to work in wide pH range, water solvent and room temperature. Starting from DMTMM, this thesis focuses on the synthesis of new amidation agents, more active and stable, leading to the drafting of two patents, one of which international. Moreover, this work examines the application of these new compounds for the cros
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Vongvilai, Pornrapee. "Dynamic Covalent Resolution: Applications in System Screening and Asymmetric Synthesis." Doctoral thesis, Stockholm : Skolan för kemivetenskap, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11200.

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Potin-Gautier, Martine. "Photoamidation d'olefines fluorees, en milieu homogene et en milieux microemulsions non aqueux." Toulouse 3, 1987. http://www.theses.fr/1987TOU30011.

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Les amides perfluores et mixtes (a doubles chaines hydrogenee et perfluoree) sont des precurseurs de tensioactifs susceptibles d'ameliorer les proprietes des mousses extinctrices, par diminution de la tension interfaciale entre l'eau et l'huile par un meilleur etalement de la mousse. Ces amides sont synthetises par photoamidation d'olefines : r::(f)-ch=ch::(2), r::(f)-ch=ch-r::(h), r::(f)-ch::(2)-ch=ch-r::(h) dans le t-butanol et dans des microemulsions de formamide
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Hande, Akshay. "Regioselective C-H Amidation Reactions using Directing Group Strategy and its Application in Organic Synthesis." Thesis, 2019. https://etd.iisc.ac.in/handle/2005/4532.

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The thesis represents an approach for the C-H bond activation using directing group strategy. The C-H activation happens through five/six-membered metallacycle through concerted metallation deprotonation. Further functionalization leads to C-N formation in the presence of an amidating reagent dioxazolone. Dioxazolone a robust and efficient amidating reagent has been utilized for the C-N bond formation reaction. The strategy has been applied for the azobenzene derivatives for further benzotriazole heterocycle synthesis. The 7-amino indoline derivatives have been synthesized at the ambient condi
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Lamani, Manjunath. "Design And Development Of Synthetic Methods Using Metal-Mediated And Metal Free Redox Reactions : Novel C-H Activations, Reductions And Oxidative Transformations." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2501.

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The thesis entitled “Design and Development of Synthetic Methods using Metal-mediated and Metal-free Redox Reactions: Novel C-H Activations, Reductions and Oxidative Transformations” is presented in 4 chapters Chapter 1; Iodine catalyzed amination of benzoxazoles: efficient metal free route to 2-aminobenzoxazoles under mild conditions. The Chapter 1 of this thesis describes iodine catalyzed C-H activation of benzoxazole with primary and secondary amines to form oxidative aminated products. Selective C-H oxidation is a frontline area of modern chemical research as it offers the opportunitie
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Lamani, Manjunath. "Design And Development Of Synthetic Methods Using Metal-Mediated And Metal Free Redox Reactions : Novel C-H Activations, Reductions And Oxidative Transformations." Thesis, 2012. http://hdl.handle.net/2005/2501.

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The thesis entitled “Design and Development of Synthetic Methods using Metal-mediated and Metal-free Redox Reactions: Novel C-H Activations, Reductions and Oxidative Transformations” is presented in 4 chapters Chapter 1; Iodine catalyzed amination of benzoxazoles: efficient metal free route to 2-aminobenzoxazoles under mild conditions. The Chapter 1 of this thesis describes iodine catalyzed C-H activation of benzoxazole with primary and secondary amines to form oxidative aminated products. Selective C-H oxidation is a frontline area of modern chemical research as it offers the opportunities
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Book chapters on the topic "Amidation reactions"

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Nesterov, Dmytro S., Luís M. T. Frija, Armando J. L. Pombeiro, and Maximilian N. Kopylovich. "Catalytic Alkane Amidation and Related Reactions." In Alkane Functionalization. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119379256.ch19.

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Anderson, Joanne E., Jannine Cobb, Roman Davis, Peter J. Dunn, Russ N. Fitzgerald, and Alan J. Pettman. "Industrial Applications of Boric Acid And Boronic Acid-Catalyzed Direct Amidation Reactions." In Sustainable Catalysis. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118354520.ch06.

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Reissig, H. U., and R. Zimmer. "Amination, Amidation, and Imidation Reactions." In Cumulenes and Allenes. Georg Thieme Verlag KG, 2008. http://dx.doi.org/10.1055/sos-sd-044-00252.

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Malleron, J. L., J. C. Fiaud, and J. Y. Legros. "Amination or Amidation of Alkenes." In Handbook of Palladium-Catalyzed Organic Reactions. Elsevier, 1997. http://dx.doi.org/10.1016/b978-012466615-3/50042-2.

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Li, Y., X. Fang, and Y. Wang. "2.1 Amide-Bond-Forming Reactions." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00002.

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AbstractAmide-bond-forming reactions are involved in at least one step in the preparation of most DNA-encoded chemical libraries (DELs) because of the versatility and DNA compatibility of these reactions. Amidation is typically achieved through the condensation of amines and carboxylic acids, which are two of the largest commercially available building-block pools because of their widespread use in medicinal chemistry for the synthesis of drug-like screening libraries.
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Benderly, A., L. Y. Dennis, and A. Bravo. "Amidation of Methyl Esters with Formamides in the Presence of KCN as the Catalyst." In Catalysis of Organic Reactions. CRC Press, 2020. http://dx.doi.org/10.1201/9781003067184-24.

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Austin, D. J., and S. M. Miller. "Reductive Amidation of Ketones (Leuckart Reaction)." In Three Carbon-Heteroatom Bonds: Esters and Lactones; Peroxy Acids and R(CO)OX Compounds; R(CO)X, X=S, Se, Te. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-021-00073.

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Tomalia, Donald A. "Some examples of dendrimer synthesis." In Polymer Chemistry. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780198503095.003.0012.

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Dendrimers are highly branched macromolecules with unique structural properties. They may be thought of as core–shell type macromolecules wherein they amplify their mass and terminal groups as a function of growth stages. These growth stages are referred to as generations (i.e. G= 0, 1, 2, . . .). They possess three key architectural features: (i) a core region; (ii) interior shell zones containing cascading tiers of branch cells (generations) with radial connectivity to the initiator core; and (iii) an exterior or surface region of terminal moieties attached to the outermost generation. With
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Lambert, Tristan H. "Functional Group Interconversion." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0005.

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Glenn M. Samm is at the University of British Columbia reported (Angew. Chem. Int. Ed. 2012, 51, 10804) the photofluorodecarboxylation of aryloxyacids such as 1 using Selectfluor 2. Jean-François Paquin at the Université Laval found (Org. Lett. 2012, 14, 5428) that the halogenation of alcohols (e.g., 4 to 5) could be achieved with [Et2NSF2]BF4 (XtalFluor-E) in the presence of the appropriate tetraethylammonium halide. A method for the reductive bromination of carboxylic acid 6 to bromide 7 was developed (Org. Lett. 2012, 14, 4842) by Norio Sakai at the Tokyo University of Science. Professor Sa
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Lambert, Tristan H. "Functional Group Interconversion." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0004.

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Chaozhong Li of the Shanghai Institute of Organic Chemistry reported (J. Am. Chem. Soc. 2012, 134, 10401) the silver nitrate catalyzed decarboxylative fluorination of carboxylic acids, which shows interesting chemoselectivity in substrates such as 1. A related decarboxylative chlorination was also reported by Li (J. Am. Chem. Soc. 2012, 134, 4258). Masahito Ochiai at the University of Tokushima has developed (Chem. Commun. 2012, 48, 982) an iodobenzene-catalyzed Hofmann rearrangement (e.g., 3 to 4) that proceeds via hypervalent iodine intermediates. The dehydrating agent T3P (propylphosphonic
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Conference papers on the topic "Amidation reactions"

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Suryanti, V., F. R. Wibowo, T. Kusumaningsih, A. H. Wibowo, S. A. Khumaidah, and L. A. Wijayanti. "Amidation reaction of eugenyl oxyacetate ethyl ester with 1,3 diaminopropane." In THE 3RD INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS SCIENCE AND TECHNOLOGY (ICAMST 2015). Author(s), 2016. http://dx.doi.org/10.1063/1.4945539.

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Pogrebnoi, Vsevolod, Natalia Sucman, and Fliur Macaev. "The amides of dehydroabietic acid in synthesys of spiropyranes with the participation of carbonyl compounds." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab16.

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The abstract presents the synthesis of new spiropyranes from substituted 5-aminoisatin 6 in multicomponent reaction with different carbonyl compounds. It is known that spiropyranes have various activities, which depend from spatial structure and substituents [1]. From the other side, previously mentioned dehydroabietic acid 1 [2] is interesting object to study due to its molecular structure, chemical and biological properties.Initially, our strategy was to obtain the substituted isatine 6 from easily accessible isatine 3. To implement that approach, previously obtained [2] 5-nitroisatine react
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Iwamoto, M., N. Sugiyama, T. Sasaki та Y. Abiko. "DOMAIN OF BINDING ACTIVITY WITH PLASMIN KRINGLE IN SYNTHESIZED C-TERMINAL PEPTIDES , OF α2-PLASMIN INHIBITOR". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644612.

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The inhibitory reaction between plasmin and α2-plasmin inhibitor (α2-PI) proceeds with two steps, a very fast reversible reaction followed by a slower irreversible transition. The first step is dependent on the interaction between lysine binding site (LBS) of plasmin and the corresponding complementary site of α2-PI (kringle binding site(KBS)). It has been reported that KBS is located in a C-terminal tryptic fragment (T-11; J. Biochem. 99, 1699 (1986)).In order to investigate which amino acid residues of T-ll play important roles in binding of plasmin kringle, we tested inhibitory activity of
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"Assessment of Formula-Based Structural Annotation of Humic Substances by Mild Chemical Derivatization and Mass Spectrometry." In Sixth International Conference on Humic Innovative Technologies "Humic Substances and Eco-Adaptive Technologies ”(HIT – 2021). Non-Commercial Partnership "Center for Biogenic Resources "Humus Sapiens" (NP CBR "Humus Sapiens"), 2021. http://dx.doi.org/10.36291/hit.2021.mikhnevich.002.

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Natural organic matter (NOM) plays an important role in the environment and its chemical properties and molecular composition reflect balance between mineralization and sequestration of organic carbon. Ultrahigh resolution mass spectrometry (e.g., FTICR MS) provides essential molecular information about NOM. However, NOM molecular heterogeneity prevents application of tandem MS experiments and direct structural information is ultimately missing leaving opportunities to only ambiguous formula-based annotation. The main aim of this work was to develop a chemical workflow to reliably examine the
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