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Published: 14 March 2023

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1

Fiorucci. "On the Chitinase target evolution, from fungi to humans." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1048358.

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Chitinase proteins are expressed in most of reigns, from fungi to mammals. This kind of proteins can cleave the chitin, the second most abundant polysaccharide in nature. Mammals do not synthesize nor are able to use it, but they express Chitinase proteins. It has been proved that this kind of proteins are involved in several pathologies. Human Acidic Mammalian Chitinase is involved in the development of pathologies related to the Th2 inflammation. It has been discovered that the inhibition of this protein allowed the reduction of the inflammation. This effect makes this protein a very interesting target for the treatment of this kind of pathologies. In this PhD thesis, the first subject is the target fishing procedure applied to a series of macrocyclic compounds endowed with antifungal activity. The result of the target fishing has been the chitinase protein, and it has been rationally designed a new derivative able to inhibit the chitinase protein with higher potency. The second theme of this work has been the computational study the complex between the rationally designed chitinase inhibitor and the human Acidic Mammalian Chitinase, to identify the most reliable binding mode of the compound inside the binding pocket. The identification of the binding mode has been followed by the design of a library of derivatives, using the information acquired after the study, to improve the activity of the series of compounds towards the Acidic Mammalian Chitinase. The last topic has been the Structure Based Virtual Screening on the Acidic Mammalian Chitinase to find novel scaffolds active as AMCase inhibitor. A first screening based on pharmacophoric filtration and docking calculations has been done, identifying a preliminary hit, on which it has been performed a substructure search, that allowed the discovery of a more active derivative. This molecule has been examined with Molecular Dynamics simulations observing modification in the binding mode during each replica. It has been done a cluster analysis used for the generation of a new pharmacophoric model. The selected cluster representatives have been used as receptors for an ensemble docking calculation that allowed the identification of a third molecule biologically active as AMCase inhibitor.

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2

G, Truglio. "Synthesis and biological evaluation of hAMCase inhibitors and anomeric equilibrium of gluco and xylopyranose derivatives in D2O." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070882.

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Asthma is considered a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. It is a chronic inflammatory disease characterized by airway inflammation, mucus hypersecretion and airway hyperresponsiveness. One of the causes of this disorder is the result of an abnormal Th2-dependent response to environmental antigens. In particular, Th2 cells produce cytokines, such as interleukin (IL)-4, IL-5, IL-9, and especially IL-13, in the airway wall, associated with the asthma symptoms. Acidic Mammalian Chitinase (AMCase) is a chitinolytic enzyme belonging to glycosyl hydrolases family. AMCase seems to be involved in Th2 inflammatory diseases, such as asthma. It has been demonstrated that during Th2-dependent inflammation IL-13 induces the AMCase expression in the airways epithelial cells and alveolar macrophages, which stimulates the release of chemokines, recruiters of proinflammatory agents. In conclusion, AMCase contributes to the pathogenesis of asthma and represents a potential therapeutic target for the treatment of this disease and other forms of Th2-mediated inflammation. Prof. Botta research group, after a careful study, designed and synthesized an innovative AMCase inhibitor, BM22 (Ki = 13.2 μM), characterized by a macrocyclic structure. The aim of this work was the study of BM22 chemical space in order to improve its activity with the exploration of the macrocyclic portion, the linker length and substitution the amidinourea terminal moiety with a diamino-triazole group. Some of these compounds have been tested against AMCase enzyme and showed a better activity compared to that of BM22. The last chapter of this thesis deals with the study of the anomeric equilibrium of xylo and glucopyranoses in D2O at room temperature. The anomeric effect is an effect that determines the increased preference of the axial position of the C1 substituent in a pyranose ring, rather than the sterically preferred equatorial position. Two models were proposed to explain this effect: Electrostatic model and Hyperconjugation model. The anomeric ratio was established by qNMR, which involved integration of resolved signals in 1H-NMR spectrum. Interesting results have been obtained, as all compounds showed a preference for α-anomer, including, surprisingly, the electron donating methoxy group as well.

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3

Balestri, Lorenzo Jacopo Ilic. "SYNTHESIS OF ANTIFUNGAL COMPOUNDS." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203145.

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Systemic fungal infections represent a threat to public health, and annually more than 150 million people suffer from fungal diseases. This worrisome data reflects the growing group of patients with immunocompromised conditions: due to cancer chemotherapy, organ transplanting or affected by AIDS, and the outbreaks of azoles resistant strains. Moreover, the global emergency caused by SARS-CoV-2 led to long term hospitalizations, and intubation increased the susceptibility to developing fungal infections. Therefore, now more than ever, the challenge of developing new antifungal drugs is dramatically urgent. Our research group has been interested in the great potential of guanylated compounds as new antifungal agents since 2007. During these 15 years, three series of derivatives, characterized by an amidinoureas scaffold, have been developed. The structure of these compounds is new and not shared with other antifungal drugs present on the market. Consequently, they show remarkably antifungal activity, especially among Candida strains resistant to azole drugs. The first chapter of my thesis deals with synthesizing new antifungal compounds with a macrocyclic amidinourea scaffold. Firstly, a novel compound, BM37, was synthesized through a convergent approach using the ring-closing metathesis (RCM)as a key step. Secondly, we decided to conduct advanced biological investigations of our lead compound, BM1. Consequently, we face the need to prepare this compound on a gram scale. To achieve this result, we changed the synthetic route and took inspiration from Fukuyama’s work designing a new strategy to obtain 1 gram of BM1. The second chapter of my thesis explores the design and synthesis of novel inhibitors targeting human chitinases. This project started when we investigated a putative target for the amidinoureas compounds endowed with antifungal activity. This research led us to the Chitinase family. In particular, our interest fell on human chitinases due to their involvement in chronic inflammatory lung diseases. The development of new human chitinase inhibitors, characterized by two different chemical scaffolds, is the aim of this second chapter. The former was the macrocyclic amidinoureas scaffold. Here three derivatives: BM56, BM57 and BM58, were synthesized and evaluated on human chitinases. The latter explored the chemical space related to the 6-piperazine-1-ylpyrazine-2-carboxamide, a new scaffold that emerged from a structure-based virtual screening. In this case, we synthesized a small, focused library of derivatives. The third chapter of my thesis describes my work as visiting PhD student at Uppsala University. During this period, I have been involved in the alkylation of the N position of 3-methyl indole with several cyclic ketones using a green and efficient amide coupling reagent, the TP3®. Finally, the last chapter contains chemical and biological data of all the compounds presented in the thesis.

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4

Korenstein, Alyssa. "Predictors of Primary Care Career Choice: A Review of AMCAS Applications of Four Graduating Classes at a New Medical School." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623466.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
The United States (U.S.) is currently facing a shortage of primary care physicians, an issue particularly salient in Arizona. The purpose of this project is to investigate predictors of students entering primary care specialties that may be apparent from their American Medical College Application Service (AMCAS) applications, in order to best serve the needs of the physician workforce. We hypothesized that factors such as female gender, older age at application (“non‐traditional” students), and being raised in a rural/underserved community background may be predictors of students who choose primary care fields. AMCAS applications are completed by aspiring medical students and contain demographic information including gender, age, race, languages spoken, and family/community characteristics. Data provided also include academic factors such as college major, grade point average (GPA), and Medical College Admissions Test (MCAT) scores. Other subjective data reported by applicants include descriptions of extracurricular activities and a personal statement. The National Resident Matching Program (NRMP) is the system used by graduating students during the last semester of medical school to match students with their choice of specialty and the residency program wherein they will spend an additional three years, minimum, in training. Based on the Association of American Medical Colleges (AAMC) designations, we are considering primary care to be Family Medicine, Pediatrics, Internal Medicine, and Medicine‐Pediatrics. We examined data from AMCAS applications of all 149 students who graduated from the University of Arizona College of Medicine‐Phoenix between 2011‐2014, and compared to their NRMP match outcomes. Comparisons were made between non‐primary care versus primary care‐overall, as well as Family Medicine alone versus all other matches given the increasing rate of specialization within Internal Medicine and Pediatrics. Multiple logistic regression revealed two predictors of primary care career choice compared to non‐primary care: having more siblings (P=.003) and non‐physician parents (P=.017). Specific to Family Medicine, several predictors were identified compared to the non‐Family Medicine cohort: a slightly greater percentage of earned community college credits (P=.03), lower MCAT physical science (P=.009), higher MCAT verbal scores (P=.02), and lower paternal education (P=.003). Our analyses suggest having a greater number of siblings and non‐physician parents may predict primary care career choice. Specific to Family Medicine, academic factors including community college enrollment and MCAT scores may be of predictive value. Though the exact implications behind these findings are unclear, it is important to continually examine such data as medical schools can shape admissions selection criteria targeted at increasing the number of graduates seeking careers in primary care.

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5

Greenberg, Fernando Guajará. "Bases para a estruturação de uma Agência Municipal de Cadastro - AMCA." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/84677.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.
Made available in DSpace on 2012-10-20T11:30:27Z (GMT). No. of bitstreams: 1 222484.pdf: 617836 bytes, checksum: 9a00d962f85a0731c4e0490e2569a212 (MD5)
Este trabalho tem como objetivo revigorar as condições de gerência administrativa pública Municipal considerando o Estatuto da Cidade e as dificuldades de implantação de infra-estrutura antecipadamente à ocupação nas cidades. Muitas são as dificuldades para o bom relacionamento entre Empresas, Poder Público e população, dando incômodos e desperdícios para o usuário final. Nesta pesquisa é proposta a criação da AMCA - Agência Municipal de Cadastro, que atuaria basicamente em três frentes: 1) Base de dados gerenciados por um Sistema de Informações Geográficas (SIG), com a criação e manutenção de sistema confiável; 2) Contratos ou Termos de Permissão de Uso de utilização dos espaços públicos, subsolo e aéreos por parte das concessionárias, bem como padronização de procedimentos, e; 3) Minimizar, pela racionalização de quaisquer serviços infra-estruturais, o incômodo e os prejuízos provocados por obras descoordenadas e fora de um controle central local, interagindo com a população muito mais ativamente, não só se pronunciando quando solicitada, mas informando antecipadamente. Vantagens da proposta são implantação imediata, banco de dados confiáveis, repasse do excedente dos recursos dos contratos a outras áreas de interesse social, resgate das atribuições e responsabilidades e facilidade de localização de problemas e de rápida e barata solução, envolvendo ajustes na mentalidade e postura das pessoas envolvidas, com resultados futuros positivos, quer pela melhor racionalização de serviços de infra-estrutura, quer pela redução do volume de obras de duração incerta e de ação desordenada e incômoda.

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6

Alhashmy, Hasan. "Fabrication of Aluminium Matrix Composites (AMCs) by Squeeze Casting Technique Using Carbon Fiber as Reinforcement." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23120.

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Composites have been developed with great success by the use of fiber reinforcements in metallic materials. Fiber reinforced metal matrices possess great potential to be the next generation of advanced composites offering many advantages compared to fiber reinforced polymers. Specific advantages include high temperature capability, superior environmental stability, better transverse modulus, shear and fatigue properties. Although many Metal Matrix Composites (MMCs) are attractive for use in different industrial applications, Aluminium Matrix Composites (AMCs) are the most used in advanced applications because they combine acceptable strength, low density, durability, machinability, availability, effectiveness and cost. The present study focuses on the fabrication of aluminium matrix composite plates by squeeze casting using plain weave carbon fiber preform (AS4 Hexcel) as reinforcement and a matrix of wrought aluminium alloy 1235-H19. The objective is to investigate the process feasibility and resulting materials properties such as hardness at macro- and micro-scale, impact and bend strength. The properties obtained are compared with those of 6061/1235-H19 aluminium plates that were manufactured under the same fabrication conditions. The effect of fiber volume fraction on the properties is also investigated. Furthermore, the characterization of the microstructure is done using Optical Microscopy (OM) and Scanning Electron Microscopy (SEM) in order to establish relationships between the quality of the fiber/aluminium interface bond and mechanical properties of the composites. In conclusion, aluminium matrix composite laminate plates were successfully produced. The composites show a good chemical bond between the fiber and the aluminium matrix. This bond resulted from heterogeneous precipitation of aluminium carbides (Al4C3) at the interface between aluminium matrix and carbon fiber. The hardness at macro- and micro-scale of the composites increases by over 50% and the flexural modulus increases by about 55%. The toughness of the composite decreases due to the presence of brittle phases which can be improved by better oxidation prevention. Also, an optimal carbon volume fraction was observed that provides optimal properties including peak hardness, peak stiffness and peak toughness.

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7

Ashton, Samuel L. "Beliefs, Practices, and Training in Marriage Preparation: A Comparison Between Members of the Association of Mormon Counselors and Psychotherapists (AMCAP) and Select Protestant Clergy." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd897.pdf.

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8

Kwan, Cheuk Hung. "Biosensors for biological nutrient monitoring /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202004%20KWAN.

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9

Zhang, Tao. "Regulation of EGY1 gene expression by environmental factors and developmental cues /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20ZHANG.

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10

Lee, On On. "Possible controls of epibiosis in the sponge : mycale adhaerens /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20LEE.

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11

Li, Hui. "Numerical modeling of South China Sea circulation /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20LI.

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12

Chan, Ka Fai. "Different statistical methods to predict sulfur dioxide concentration and ozone concentration at Tung Chung /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20CHAN.

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13

Huang, Xiaofeng. "Formation mechanisms of water-soluble organic compounds in atmospheric aerosols /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202005%20HUANG.

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14

Guan, Rui. "Bioavailability and toxicity of trace metals to the cladoceran daphnia magna in relation to CD exposure history /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20GUAN.

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15

Chen, Xi. "Development of a multiphase chemical model and its application in evaluation of gas-aerosol partitioning of glyoxal /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20CHEN.

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16

Cheung, Yee Ying. "Modeling upwelling circulation over continental shelf in the northern South China sea /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20CHEUNG.

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17

So, Wai Kar. "Sex pheromone in caenorhabditis : defining its identity and its perception pathway /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20SO.

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18

Lau, Ken Wan Keung. "The identification of novel marine bacteria, and the construction of single chain fragment variable antibodies for the control of a viral pathogen /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20LAU.

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19

Wang, Tingliang. "The identification and characterization of genes involved in cadmium response in chlamydomonas reinhardtii /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20WANG.

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20

Yang, Lai Hung. "Antifouling compounds from the marine sponge acanthella cavernosa and its associated microbes /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20YANG.

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21

Lo, Chi On. "Time-based source apportionment of air pollutants for Hong Kong /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20LO.

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Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2007.
M.Phil. in Atmospheric Environmental Science. Includes bibliographical references (leaves 82-83). Also available in electronic version.

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22

Zhang, Wen. "Dynamics and diversity of prokaryotic communities in marine sediments of Hong Kong /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20ZHANG.

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23

Yu, Zhiliang. "Use of ValRS-IleRS interparalog distance for the analysis of the phylogenetic relationships between methanopyrus isolates from the atlantic, pacific and indian oceans /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20YU.

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24

Hung, Oi Shing. "Effects of environmental factors on biofilms and subsequent larval attachment of benthic marine invertebrates /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20HUNG.

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25

Huang, Yi-Li. "Potential roles of bacterial quorum sensing and biofilm formation in the biofouling process /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20HUANG.

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26

Chiu, Man Ying. "Biological and ecological processes that intervene the larval and juvenile stages of the gastropod crepidula onyx /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20CHIU.

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27

Cheung, Ma Shan. "Trophic transfer of metals along marine rocky shore food chains /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20CHEUNG.

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28

Li, Honglei. "Investigation of genes involved in larval attachment and metamorphosis of biofouling species hydroides elegans and balanus amphitrite /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20LI.

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29

Xu, Jie. "Nutrient limitation in the pearl river estuary, Hong Kong waters and adjacent South China Sea waters /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20XU.

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Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007.
Ph.D. in Marine Environmental Science. Includes bibliographical references (leaves 168-184). Also available in electronic version.

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30

Ho, Yam Tat. "Dynamics of nutrients and phytoplankton biomass and production in Hong Kong waters /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202007%20HO.

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31

Zhong, Huan. "Geochemical and biological controls of mercury availability from marine sediments /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202008%20ZHONG.

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32

Chen, Bingzhang. "Trophic interactions within the microbial food web in Hong Kong coastal waters and the South China Sea /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202008%20CHEN.

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33

Man, Marty Yu Kit. "Inter-comparison of Gaussian air dispersion models for regulatory applications in Hong Kong /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202008%20MAN.

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34

Yu, Huan. "Size distributions of elemental carbon, organic carbon, and polycyclic aromatic hydrocarbons in ambient aerosols of the Pearl River Delta region /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202009%20YU.

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35

Zhang, Zhenxi. "Modeling downwelling circulation over continental shelf in the northern South China Sea /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202009%20ZHANG.

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36

Jiang, Yuelu. "Cell death, growth and physiological responses of a marine diatom to silicon and nitrogen starvation and resupply in the light and dark /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202009%20JIANG.

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37

Lam, Ka Sin. "The chemical nature of diatom-derived settlement cue(s) of the marine polychaete hydroides elegans (Haswell) /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202003%20LAM.

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38

Huang, Pong-Lai. "Modelling of air quality in street canyons /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202003%20HUANG.

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39

Finsterhölzl, Lydia [Verfasser], and Michael [Akademischer Betreuer] Melter. "Untersuchung des Einsatzes der Serumantikörper Anti-Chitobiosid Kohlenhydrat Antikörper (ACCA), Anti-Laminaribiosid Kohlenhydrat Antikörper (ALCA), Anti-Mannobiosid Kohlenhydrat Antikörper (AMCA), Anti-Chitin Antikörper (Anti-C) und Anti-Laminarin Antikörper (Anti-L) in Verbindung mit Anti-Saccharomyces cerevisiae Ig G Antikörper (gASCA) zur Diagnostik und Stratifizierung von Kindern und Jugendlichen mit Morbus Crohn / Lydia Finsterhölzl. Betreuer: Michael Melter." Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1042055041/34.

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40

Ayad, Houssam. "Antenna Performance Control using Metamaterials." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENT013/document.

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Le travail de cette thèse est en rapport avec les métamatériaux et ses applications. Tout d’abord, un état de l’art est dressé en présentant leur évolution depuis leur apparition en 19ème siècle jusqu’au nos jours. Les notions sur les milieux chirale, bi-anisotrope, cristaux photoniques et quelques applications dans ces milieux sont données. Ensuite, nous présentons les équations classiques de Maxwell dans les milieux complexes. L’effet bi-anisotrope dans les métamatériaux est ensuite validé par l’extraction des paramètres caractéristiques du matériau main gauche (LHM). La validation a été faite en utilisant deux types différents du résonateur avec inclusion (SRR). Les métamatériaux sont également étudiés comme des cristaux photoniques quand les dimensions utilisées sont de l’ordre de la longueur d’onde correspondant.De plus, les résonateurs SRR et multi-SRR sont analysés du point de vue analytique et électromagnétique afin d’extraire leur fréquence de résonance. Par conséquent, ces composants peuvent être introduits dans différents types de conception; La surface conductrice magnétique artificielle (AMC) illustre un cas explicite et efficace de ces derniers. Une antenne dipôle, placée sur cette surface à la place d’un plan de masse conventionnel, a été étudiée comme une application des métamatériaux. Les résultats relatifs sur la directivité, le gain et le coefficient de réflexion montrent une nette amélioration. Une antenne multi-bandes, comme une autre application des métamatériaux, a également été conçue et simulée. Le résonateur SRR est inséré dans l’antenne de départ afin de créer une autre résonance, et par conséquent une autre bande est ainsi créée
The work in this thesis deals with metamaterials, its components and applications. A historical overview about these materials, features and researches in the domain are presented. Chiral media, binaisotropic materials and photonic crystals are also studied in order to visualize physics behind metamaterials.Electromagnetic properties in complex media are widely investigated. Starting from Maxwell’s equations, bi-anisotropic materials and their effect are deeply analyzed whereas two types of Split Ring Resonator (SRR) are treated to determine constitutive parameters of Left Handed Materials (LHM). The metamaterials are also studied as photonic crystals since the effective medium approach is not applicable when the dimensions of the inclusions tend to the operating wavelength.Moreover, SRRs and Multi SRRs are synthesized analytically and electromagnetically in order to extract their resonant frequencies. Consequently, these components could be introduced in any design; Artificial Magnetic Conductor (AMC) surface is an efficient case. Thus, a low profile antenna positioned over such surface is examined as an application of metamaterials. The results of directivity, gain and reflection coefficient are of great importance and affirm the employing of metamaterials in such applications. A dual band PCB antenna, as another application of metamaterials, is designed and simulated. The SRR element studied in the previous chapters is used as the trap which inserted in the arm of the antenna in order to create another resonance, and consequently another band is created

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41

WANG, YUNG-HSIANG, and 王永祥. "Monitoring on truncation of AMCase treated with shRNA." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/42u2ch.

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碩士
明志科技大學
化學工程系生化工程碩士班
104
The prevalence of asthma increases recently. The more develops, the more prevails. Most of the injuries for the asthma are irreversible. Now, the common therapy on asthma is bronchodilator agents. In the indicator of asthma, the acid mammalian chitinase (AMCase) was identified in patient. The syndrome can be improved when the AMCase blocked. The inhibitors of AMCase are chemicals or small interfering RNA (siRNA). SiRNA is a short nucleic acid fragment to interference or silence target mRNA by pairing to form double-stranded RNA molecules. The double-stranded RNA molecule recruits enzyme or protein complex with ribozyme activity to cleave the target mRNA. Then, more short nucleic acid fragments are produced and the target mRNA is degraded more efficiently. Finally, the proteins translated from the target mRNA are ceased. The physical function of the proteins from target mRNA is lost. However, the real sequence of target mRNA processed by the siRNA is still unclear. The expression of AMCase is inhibited by siRNA 1336 has been reported. The cells treated with siRNA 1336 were collected. After RNA extraction, the technique of rapid amplified RNA end (RARE) was applied. The truncation site on 3’ end of AMcase mRNA is identified at 1,365.

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42

Chen, Hui Shan, and 陳惠珊. "The regulation of acidic mammalian chitinase ( AMCase ) expression in lung epithelium." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/52250658635889218248.

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碩士
長庚大學
醫學生物技術暨檢驗學系
99
Several recent studies showed that the acidic mammalian chitinase ( mAMCase ) were highly expressed in the lung epithelial cells of asthmatic mice. Also, the expression of hAMCase in the lungs of asthma patients was significantly higher as compared with that of healthy individuals, indicating a role of chitinase in asthma. The current study therefore aimed to identify and construct the promoters which drive mAMCase and hAMCase expression. Then the reporter system using such promoter candidates to express luciferase was utilized for the study of the allergic mediators on mAMCase and hAMCase expression, leading to the understanding of mAMCase and/or hAMCase contributing to asthma. First, the specific mouse mAMCase promoter and four candidates of hAMCase promoter, namely hAMCase-H, SH, SSH and SB, were cloned according to the results of bioinformatic analysis. The reporter vectors were constructed containing the above promoter sequences and encoding luciferase. The mAMcase and/or hAMCase expression in the cells were therefore evaluated by measuring the luciferase activity in the cells, which were transfected with the reporter vector. A negative control, 2H, was also cloned. Results showed that the significant higher level of luciferase activity in the mouse lung epithelium MLE-12 cells receiving mAMCase reporter. In the human lung cells A549 being transfected with hAMCase reporters, it showed that SB initiated the highest level of luciferase activity. Moreover, there seemed to be no effects on luciferase signals, while MLE-12 treating with different doses of inflammatory ( IL-13 and TNF-α ) and anti-inflammatory ( TGF-β ) factors and A549 treating with IL-10, IL-13, TNF-α and anti-IL-13. In contrast, the luciferase activity was significantly reduced while MLE-12 treating with anti-inflammatory mediators including anti-IL-13 and IL-10 as well as in A549 treating with TGF-β. In addition, not only chitinase-EIRE but also glucocorticoid receptor appeared to be included in the sequences of mAMCase and hAMCase promoters. The effects of adding Dexamethason and chitin derivatives were also determined. It showed that Dexamethason was only able to enhance the luciferase activity in MLE-12 cells receiving mAMCase promoter, but not in A549 cells containing hAMCase promoter. However, most importantly, the exposure of chitin elicited the luciferase activity in both MLE-12 and A549 cells, indicating the correct candidates of chitinase promoters. Although more studies are required to understand the role of chitinase contributing to the development of asthma, the current study provides a practical tool and basis of utilizing chitinase promoters for further investigation.

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43

YANG, KUNG-WEN, and 楊孔文. "Identifying Truncation site of AMCase Treated with siRNA and Analyzing the Ring Finger Region of cbl-b." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/91473250304039477261.

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44

Yang, Ching Jen, and 楊靜仁. "Using a fed-batch culture process to enhance rAAV production in baculovirus/insect system and development of asthma therapy with rAAV-mediated AMCase shRNA." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/23561730640106449524.

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博士
長庚大學
化工與材料工程研究所
97
Recombinant adeno-associated virus (rAAV) is one of the most promising vectors for human gene therapy. However, the production systems that are currently available have a limited capacity and cannot provide sufficient quantities of rAAV for preclinical or clinical trials. Many novel methods for improving rAAV production have been developed, but few researchers have focused on the culture process. In this study, we use a fed-batch culture system to enhance rAAV yield in the baculovirus/insect cell system. When the insect cells were co-infected with MOI=5 of Bac-GFP at a ratio of 1:9:9 (Bac-GFP: Bac-Rep: Bac-VP), the fed-batch culture achieved optimal rAAV yields. In batch culture, the optimal cell density for producing rAAV was found to be 1´106 cells/ ml, and the highest rAAV yield (1.22´108 IVP/ ml, 122 IVP/ cell) occurred at day 5 post-infection. In the fed-batch culture, and the highest rAAV yield was 2.40´108 IVP/ ml (240 IVP/ cell). The batch and fed-batch cultures have very similar costs; however, the rAAV yield was 2.6-fold higher in the fed-batch culture system compared with the batch culture system. Therefore, this method offers an economical, rapid procedure for rAAV production. Moreover, in this study, rAAV was utilized to deliver RNAi for the development of targeting therapy against allergic asthma. Growing evidence suggests that an increased expression of acidic mammalian chitinase (AMCase) may play a role in the pathogenesis of asthma. In the present study, we sought to develop a RNA-interference approach to suppress allergic asthma in mice through silencing of AMCase expression. Mice sensitized with ovalbumin (OVA) were given intratracheal administration of a recombinant adeno-associated virus expressing short hairpin RNA (rAAV-shRNA) against AMCase. In OVA-sensitized mice, the development of allergic symptoms was significantly associated with elevated AMCase expression. After administration of rAAV-shRNA, there was a significant reduction of AMCase expression in the lung and in BALF cells of sensitized mice. Sensitized mice receiving rAAV-shRNA showed a significant improvement in allergic symptoms, including airway hyperresponsiveness (AHR), eosinophil infiltration, eotaxin, IL-13 secretion in BALF and serum OVA-specific IgE level. Our data suggest the hyperexpression of AMCase in asthma can be suppressed by rAAV-mediated shRNA. Silencing AMCase expression by shRNA may be a promising therapeutic strategy in asthma.

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45

Ling, Li-Min, and 凌立民. "The Study of AMCA System Performance of IEEE 802.15.4e." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/13571958957725466832.

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碩士
國立臺灣大學
電子工程學研究所
104
IEEE 802.15.4 is a suitable standard to be adopted for wireless sensor networks. It defines the communication physical layer (PHY) and media access control layer (MAC) for wireless personal area network (WPAN). Recently, with the multidisciplinary development of Internet of Things (IoT) the WSN becomes more powerful for its functions, e.g. the wireless sensor and actuator network (WSAN). IEEE 802.15.4e standard is designed to support the complicated development of WSN/WSAN. It officially defines multi-channel communication protocols as part of the standard. In the standard, multi-channel communication can be categorized into beacon-enabled as example of Deterministic & Synchronous Multi-Channel Extension (DSME) and non-beacon enabled as example of Asynchronous Multi-Channel Adaption (AMCA). Traditionally it has flexibility on variable unit data length for MAC layer on non-beacon enabled WSN but less performance balanced due to unpredictable waiting time for network access to every node in the network. With the introduction of the AMCA, it can run with different MAC unit data lengths in different channels in parallel so it’s getting more use cases. We propose enhancements based on native AMCA of the IEEE 802.15.4e and build up an energy analysis model for comparing of native AMCA and enhanced AMCA modes. There are main four approaches to our proposition and the algorithms are easy to be implemented on a micro controller system as a practical method for real deployment of WSN. We finally use OPNET network simulator software to form networks with different node sizes under mesh and cluster-tree hybrid topologies as simulation scenarios. The results present our E-AMCA approaches have better performance than N-AMCA especially in the networks with high volume nodes.

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46

Lian, Nan-Tzu, and 連楠梓. "The study of corrosion wear and laser cutting of 6061 AMCs." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/01659419935115264654.

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47

Palo, Rabindra Nath. "Tribal development fostered through agency marketing co-operative society (AMCS), Tikabali, Orissa." Thesis, 1995. http://hdl.handle.net/2009/4676.

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48

Chiu, Po-I., and 邱博異. "Prediction and comparison of a axial fan test results from the AMCA tunnel." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/97426549941903443944.

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碩士
國立雲林科技大學
機械工程系碩士班
99
The object of this study was to investigate the tunnel axial flow fan, manufacturers to design blades for the base. Draw the same size but the blade angle of seven groups of different 3-D shape of the axial fan, and wind tunnel simulation of the overall test flow boundary, change to a different pressure, speed of the boundary set.By a CFD simulation analysis is performed in this study with professional turbomachinery analysis software FINE/Turbo.Full multi-grid strategy and multistage Runge-Kutta are considered for computation. Analysis of the distribution of the fan the whole flow field, and prediction fan performance curve. In this study, the AMCA 210-07 standard wind tunnel apparatus is used for the verification of fan performance. In addition to large errors in wind capacity under,the test results reveal reasonable agreement with those of the numerical ones.The similar law of the speed change performance parameters of the conversion, calculated at different speeds of air flow and pressure, and comparison to fineturb simulation and calculated data. From the simulation results verify the law of similarity can be applied not only on the derivation of the formula, the derived data on the numerical simulation is quite accurate. Finally, the blade angle from a variety of different models to simulate.From the simulation results found in the top of the blade root and leaf angle, the lower the relative performance can be improved. The results and data are then taken as the reference for the optimization of turbomachinery design.

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Chen, Huang-Hsien, and 陳煌憲. "The Analysis of Calibration and Sensitivity Study of Air Flow in AMCA Wind Tunnel." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/88755423689052622892.

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碩士
國立清華大學
工程與系統科學系
98
Taiwan plays an important role in the whole world on the fan and forced draught blower market. Taiwan must set the standard for its flow of fan to make the dependable basis. AMCA wind-tunnel generally used in such fan function tests of heat dissipation as CPU of IT industry,etc. the correcting of the flow meter usually send to Inspection Bureau of the national standard but there are some disadvantages in high cost. This thesis studies the feasible method to correct instrument and equipment. In the small flow, we use the device with the compressibility factor Theory (PV =ZmRT) to correct the amount of air flow. In order to calculate the total amount of air through wind tunnel, we precisely,we design a tank. After a while, the air passing through wind tunnel is selected into the tank. We observe the difference of height in water level in U monometer and calculate the pressure in the tank; In higher flow, we find other methods ,for example, wind velocity meter. In base of ideal gas equation, we calculate error between the flow of predicting and the flow measured by the wind-tunnel. Finally, we discuss the pressure difference in different point.

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Dai, Rui. "Rbc Lifespan Uncertainty: Models and Anemia Management Robustness." 2013. https://scholarworks.umass.edu/theses/1030.

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This thesis discusses the modeling of uncertainty of red blood cell (RBC) lifespan distribution in patients suffering from Chronic Kidney Disease(CKD) patients, whose anemia is managed through periodic dosing of erythropoietin (EPO). In healthy individuals, RBCs containing hemoglobin (Hgb) are produced in the bone marrow. When oxygen carried by hemoglobin is transported to human tissues throughout the body, the kidneys sense reduced level of Hgb and secretes EPO that simulates proliferation of red cell precursors and eventually producing red blood cells. However, in CKD patients, their kidneys fail to secrete enough EPO, so that too few of RBCs are produced to maintain a sufficient Hgb level. As a result, artificial EPO dosing is required when the kidney loses this function to avoid anemia. To develop effective artificial EPO dosing schemes, it is important to have models of how EPO does dynamically affect hemoglobin levels. Since there is significant uncertainty in this process, it is equally valuable to have mathematical models of such uncertainties, and in this thesis we focus on uncertainty in the lifespan of red blood cells. In this thesis, we consider two different types of models for RBC lifespan uncertainty: the time-invariant and time-varying cases. In the former, we treat the probabilistic distribution of cell lifespans as fixed for a given patient, but variable (uncertain) over the population. In the latter case, the cell lifespan distribution can change from moment to moment for a given patient. Amongst several possible choices of RBC lifespan distributions, this thesis will focus on the gamma distribution. For the time-invariant model, a first-order gamma distribution is selected as the nominal distribution, and a multiplicative error model is proposed to analyze the impact of lifespan uncertainty on anemia management. In the time-varying case, the lifespan distribution is not fixed in time, but allowed to switch over a finite collection of gamma distributions. In other words, each newly-born RBC has a lifespan coming from a distribution chosen from a collection. Both of these models are analyzed so as to evaluate the impact of lifespan uncertainty on the performance of anemia management schemes; including stability and response time.

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