Academic literature on the topic 'Ambrosia artemisiifolia, Amb a 1, ragweed'
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Journal articles on the topic "Ambrosia artemisiifolia, Amb a 1, ragweed"
1
Zhukova, N. N., M. V. Manzhos, and A. V. Seleznev. "Examining sIgE-profile in patients with ambrosia allergy in Samara." Russian Journal of Immunology 23, no. 4 (October 15, 2020): 473–78. http://dx.doi.org/10.46235/1028-7221-422-esi.
Full textAbstract:
It is considered that Ambrosia trifida is not widespread in Russia, thereby avoiding its threatening effects to populational health. However, there are some areas in Russia where more than half of land area is covered by Ambrosia trifida. Many such foci are found in the Samara, Orenburg regions, Tatarstan and Bashkiria. Ambrosia trifida is distributed in Central Russia, the North Caucasus region and Siberia. The objective of the study was to examine specific IgE-profile in ragweed sensitized patients in the Samara region. A clinical and allergy examination of 969 patients with allergic rhinitis was performed. Allergic diagnostics was performed by using skin testing (prick-test) with standard set of pollen, household, and epidermal allergens. The data of skin tests in patients co-sensitized with ragweed and Artemisia allowed to analyze IgE-antibodies specific to the major Ambrosia (Amb a 1, Аmb. trifida) and Artemisia (Art v 1) allergens. Patients with negative skin test for the Amdrosia artemisiifolia and clinical manifestations of seasonal allergy were assessed for level of sIgE-antibodies nAmb a 1 and Amb trif. Skin test data demonstrated that seasonal and combined forms of allergic rhinitis dominated in patients examined. In particular, positive skin test data for pollen allergens dominated (50.6%) among all allergen groups so that more than half of them belonged to weed pollen allergens. Patients challenged with skin tests for Artemisia and ragweed allergens more likely displayed positive reaction to the Artemisia allergen (71.27%) and Ambrosia artemisiifolia (50.88%). Co-sensitization (to Artemisia and ragweed) prevailed in this geographic region featured with equal rate of simultaneously detected sIgE specific to the two types of ragweed and artemisia (nAmb a 1 + nArt v 1 + Amb trif) as well as Ambrosia trifida and Artemisia (Amb trif + nArt v 1). Almost half of the patients with negative Ambrosia art. prick-test were found to bear sIgE specific to Amb trif. Further investigation will help to better understand this phenomenon and take a fresh look at diagnostics and treatment of ragweed allergy in relevant geographic area.
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Singer, Ben D., Lewis H. Ziska, David A. Frenz, Dennis E. Gebhard, and James G. Straka. "Research note: Increasing Amb a 1 content in common ragweed (Ambrosia artemisiifolia) pollen as a function of rising atmospheric CO2 concentration." Functional Plant Biology 32, no. 7 (2005): 667. http://dx.doi.org/10.1071/fp05039.
Full textAbstract:
Although the impact of increasing atmospheric carbon dioxide concentration ([CO2]) on production of common ragweed (Ambrosia artemisiifolia L.) pollen has been examined in both indoor and outdoor experiments, the relationship between allergen expression and [CO2] is not known. An enzyme-linked immunosorbent assay (ELISA) was used to quantify Amb a 1, ragweed’s major allergen, in protein extracted from pollen of A. artemisiifolia grown at different [CO2] values in a previous experiment. The concentrations used approximated atmospheric pre-industrial conditions (i.e. at the end of the 19th century), current conditions, and the CO2 concentration projected for the middle of the 21st century (280, 370 and 600 μmol mol–1 CO2, respectively). Although total pollen protein remained unchanged, significant increases in Amb a 1 allergen were observed between pre-industrial and projected future [CO2] and between current and projected future [CO2] (1.8 and 1.6 times, respectively). These data suggest that recent and projected increases in [CO2] could directly increase the allergenicity of ragweed pollen and consequently the prevalence and / or severity of seasonal allergic disease. However, genetic and abiotic factors governing allergen expression will need to be better established to fully understand these data and their implications for public health.
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Traidl-Hoffmann, Claudia. "Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa." Kompass Pneumologie 7, no. 2 (2019): 86–87. http://dx.doi.org/10.1159/000497001.
Full textAbstract:
Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen. Therefore ragweed is becoming domestic in non-invaded areas which in turn will increase the sensitization rate. So far 11 ragweed allergens have been described and, according to IgE reactivity, Amb a 1 and Amb a 11 seem to be major allergens. Sensitization rates of the other allergens vary between 10 and 50%. Most of the allergens have already been recombinantly produced, but most of them have not been characterized regarding their allergenic activity, therefore no conclusion on the clinical relevance of all the allergens can be made, which is important and necessary for an accurate diagnosis. Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen extract or Amb a 1 only. In order to improve ragweed pollen AIT, new strategies are required with higher efficacy and safety.
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Traidl-Hoffmann, Claudia. "Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa." Kompass Dermatologie 6, no. 4 (2018): 206–7. http://dx.doi.org/10.1159/000492639.
Full textAbstract:
Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen. Therefore ragweed is becoming domestic in non-invaded areas which in turn will increase the sensitization rate. So far 11 ragweed allergens have been described and, according to IgE reactivity, Amb a 1 and Amb a 11 seem to be major allergens. Sensitization rates of the other allergens vary between 10 and 50%. Most of the allergens have already been recombinantly produced, but most of them have not been characterized regarding their allergenic activity, therefore no conclusion on the clinical relevance of all the allergens can be made, which is important and necessary for an accurate diagnosis. Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen extract or Amb a 1 only. In order to improve ragweed pollen AIT, new strategies are required with higher efficacy and safety.
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Zbîrcea, Lauriana-Eunice, Maria-Roxana Buzan, Manuela Grijincu, Elijahu Babaev, Frank Stolz, Rudolf Valenta, Virgil Păunescu, Carmen Panaitescu, and Kuan-Wei Chen. "Relationship between IgE Levels Specific for Ragweed Pollen Extract, Amb a 1 and Cross-Reactive Allergen Molecules." International Journal of Molecular Sciences 24, no. 4 (February 17, 2023): 4040. http://dx.doi.org/10.3390/ijms24044040.
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Ragweed (Ambrosia artemisiifolia) pollen is a major endemic allergen source responsible for severe allergic manifestations in IgE-sensitized allergic patients. It contains the major allergen Amb a 1 and cross-reactive allergen molecules, such as the cytoskeletal protein profilin, Amb a 8 and calcium-binding allergens Amb a 9 and Amb a 10. To assess the importance of Amb a 1, profilin and calcium-binding allergen, the IgE reactivity profiles of clinically well-characterized 150 ragweed pollen-allergic patients were analysed regarding specific IgE levels for Amb a 1 and cross-reactive allergen molecules by quantitative ImmunoCAP measurements, IgE ELISA and by basophil activation experiments. By quantifying allergen-specific IgE levels we found that Amb a 1-specific IgE levels accounted for more than 50% of ragweed pollen-specific IgE in the majority of ragweed pollen-allergic patients. However, approximately 20% of patients were sensitized to profilin and the calcium-binding allergens, Amb a 9 and Amb a 10, respectively. As shown by IgE inhibition experiments, Amb a 8 showed extensive cross-reactivity with profilins from birch (Bet v 2), timothy grass (Phl p 12) and mugwort pollen (Art v 4) and was identified as a highly allergenic molecule by basophil activation testing. Our study indicates that molecular diagnosis performed by the quantification of specific IgE to Amb a 1, Amb a 8, Amb a 9 and Amb a 10 is useful to diagnose genuine sensitization to ragweed pollen and to identify patients who are sensitized to highly cross-reactive allergen molecules present in pollen from unrelated plants, in order to enable precision medicine-based approaches for the treatment and prevention of pollen allergy in areas with complex pollen sensitization.
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Rogers, B. L., J. P. Morgenstern, I. J. Griffith, X. B. Yu, C. M. Counsell, A. W. Brauer, T. P. King, R. D. Garman, and M. C. Kuo. "Complete sequence of the allergen Amb alpha II. Recombinant expression and reactivity with T cells from ragweed allergic patients." Journal of Immunology 147, no. 8 (October 15, 1991): 2547–52. http://dx.doi.org/10.4049/jimmunol.147.8.2547.
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Abstract This study defines the complete primary structure of Amb alpha II, an important allergen produced by short ragweed (Ambrosia artemisiifolia). The deduced amino acid sequence derived from the cDNA indicates that Amb alpha II shares approximately 65% sequence identity with the Amb alpha I multigene family of allergens. Full-length cDNA encoding Amb alpha I.1 and Amb alpha II have been expressed in E. coli and purified. An in-frame linker encoding polyhistidine has been added to the 5' end of the cDNA to facilitate purification using Ni2+ ion affinity chromatography, yielding greater than 90% pure recombinant protein in a single step. T cells from patients allergic to ragweed proliferate in response to pollen extract as well as purified recombinant Amb alpha I.1 and Amb alpha II. T cell lines established using either Amb alpha I.1 or II as the stimulating Ag exhibit a high level of cross-reactivity to both proteins. This result is entirely consistent with the extensive primary sequence identity shared by these two proteins. These data suggest that allergic humans recognize shared T cell epitopes on these two related molecules.
7
Bond, J. F., R. D. Garman, K. M. Keating, T. J. Briner, T. Rafnar, D. G. Klapper, and B. L. Rogers. "Multiple Amb a I allergens demonstrate specific reactivity with IgE and T cells from ragweed-allergic patients." Journal of Immunology 146, no. 10 (May 15, 1991): 3380–85. http://dx.doi.org/10.4049/jimmunol.146.10.3380.
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Abstract The relationship between the structure and abundance of an inhaled protein and its potential for causing an allergic response is unknown. This study analyzes Amb a I, a family of related proteins formerly known as Ag E, that comprise the major allergens of short ragweed (Ambrosia artemisiifolia). T cells isolated from ragweed allergic patients were shown to proliferate in response to purified Amb a I.1 protein from pollen in in vitro secondary cultures, demonstrating the presence of T cell stimulatory epitopes in Amb a I.1. Three recombinant forms of Amb a I (Amb a I.1, Amb a I.2, and Amb a I.3) obtained as cDNA derived from pollen mRNA were expressed in bacteria. All three recombinant forms were shown to be specifically recognized by pooled ragweed-allergic human IgE on immunoblots, confirming these gene products are important allergens. An examination of immunoblots probed with sera derived from allergic patients revealed a variation in IgE binding specificity. A minority of patients' IgE exclusively reacted with recombinant Amb a I.1, whereas most patients' IgE reacted with Amb a I.1 as well as Amb a I.2 and Amb a I.3 proteins. A detailed examination of the reactivity of T cells derived from 12 allergic patients to these recombinant Amb a I forms revealed that these allergens are all capable of stimulating T cell proliferation in in vitro assays. It is concluded that the allergic response to ragweed pollen in most allergic patients is composed of a reaction to multiple related Amb a I proteins at both the B and T cell levels.
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Chapoval, Svetlana P., Teresa Neeno, Christopher J. Krco, Eric V. Marietta, Jerry Harders, and Chella S. David. "HLA-DQ6 and HLA-DQ8 Transgenic Mice Respond to Ragweed Allergens and Recognize a Distinct Set of Epitopes on Short and Giant Ragweed Group 5 Antigens." Journal of Immunology 161, no. 4 (August 15, 1998): 2032–37. http://dx.doi.org/10.4049/jimmunol.161.4.2032.
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Abstract We have investigated the genetic and molecular basis of immune responsiveness to short ragweed (SRW) (Ambrosia artemisiifolia) extract, and group 5 allergens from short and giant (Ambrosia trifida) ragweed using transgenic mice expressing DQ6 (HLA-DQA1*0103, HLA-DQB1*0601) and DQ8 (HLA-DQA1*0301, HLA-DQB1*0302) genes in class II knockout (Aβ0) mice. Panels of overlapping peptides spanning the Amb a 5 and Amb t 5 Ags were synthesized. Mice were immunized with whole SRW extract or individual peptides s.c. and lymph node cells (LNC) were challenged in vitro. Strong T cell responses to SRW extract were measured in both HLA-DQ transgenic mice, while control, HLA-DQ6−/DQ8−/H-2Aβ0, mice were unresponsive. IL-5 and IL-10 were the primary cytokines produced by in vitro challenged LNC of SRW-primed transgenic mice. HLA-DQ6-restricted T cell responses were detected to all three peptides of Amb t 5 and two determinants (residues 1–20 and 11–30) on Amb a 5. In contrast, LNC of HLA-DQ8 mice did not recognize peptide 11–30 of Amb t 5 Ag, but recognized several Amb a 5 determinants. The immune response in transgenic mice was dependent upon CD4+ T cells and was HLA-DQ restricted. Primed with purified Amb t 5, both transgenics recognized peptide 21–40, and an additional DQ6-restricted epitope was found within residue 1–20. SRW-immunized HLA-DQ6 mice respond to peptide 11–30 of Amb a 5, while HLA-DQ8 mice strongly recognize peptide 1–20. These results demonstrate the specificity of HLA class II polymorphism in allergen sensitivity and pave the way for developing antagonistic peptides for desensitization.
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Wang, Weiqian, Qingyue Wang, Senlin Lu, Yichun Lin, Miho Suzuki, and Yuma Saito. "Behavior of Autumn Airborne Ragweed Pollen and Its Size-Segregated Allergens (Amb a 1): A study in Urban Saitama, Japan." Atmosphere 14, no. 2 (January 26, 2023): 247. http://dx.doi.org/10.3390/atmos14020247.
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The prevalence of ragweed (Ambrosia artemisiifolia) pollinosis has been increasing worldwide. This study focused on the behavior of autumn airborne pollen and the major ragweed allergen -Amb a 1 particle in urban Saitama, Japan, in 2016. Burkard sampler results showed that the airborne ragweed pollen scattering season was from September 1st to October 9th. Over 83% of sampling events had pollen counts of over 13 grains/m3, indicating the high potential health risks of ragweed pollen in the atmosphere. The results of a surface plasmon resonance immunoassay (SPR) indicated that the average Amb a 1 count was about 16.5 pg /pollen. The airborne Amb a1 concentration was up to 4.7 ng/m3, of which about 45% was accumulated in ultrafine particles, such as particulate matter with a diameter ≤1.1 µm (PM1.1). Although ragweed pollen was hardly observed during the October 14th–17th sampling campaign, the concentration of ambient Amb a 1 particles in PM1.1 was also determined to be 4.59 ng/m3, which could be explained by the longer scattering of fine particles in the atmosphere. Pearson correlation coefficient analysis results showed that temperature (daily, r = 0.41; event, r = 0.87) could affect the behavior of the airborne pollen counts, and ambient water-soluble ions (such as Ca2+ and NO3−) could affect Amb a1 in PM1.1. Additionally, air mass trajectories and wind rose results indicated that air masses with long-range transportation could also influence the temporary behavior of Amb a1 and pollen counts via the wind. Mugwort and Humulus japonicus pollens were also observed to extend pollen scattering periods. Airborne pollen and allergenic particles could be considered air pollutants, as they pose health risks and are susceptible to environmental influences.
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Zhukova, N. N., M. V. Manzhos, L. R. Khabibulina, and E. Yu Syrtsova. "CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION." Medical Immunology (Russia) 23, no. 4 (October 19, 2021): 921–26. http://dx.doi.org/10.15789/1563-0625-cai-2210.
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Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed.
Dissertations / Theses on the topic "Ambrosia artemisiifolia, Amb a 1, ragweed"
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CIAPPETTA, SILVIA. "Study of intra and inter population variability of common ragweed (Ambrosia artemisiifolia L.) in relation to Amb a 1 isoforms and their allergenicity." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/101832.
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The alien plant Ambrosia artemisiifolia L. (common ragweed) is one of the main allergenic species in Europe and especially in Northern Italy, where it has become the second cause of respiratory allergy in the last two decades.
In a context of climate changing, it is very important to understand what factors the allergenicity of pollen, which is primarily determined by the presence of major allergens, depends on. Specifically it should be very interesting to define if allergenicity is dependent on environmental conditions, acting as non-heritable epigenetic factors, or on heritable elements. The objective of this thesis was to study the allergenicity variation among pollen samples from different ragweed plants/populations and to identify the mechanisms and factors contributing to the variability. To this aim, seeds from ragweed Canadian, French and Italian populations, were collected and used to grow plants both “in standard natural conditions”, where the temperature (T), humidity (H) and light (L) changed during plant development, and in “controlled conditions” where environmental parameters (T, H, L) were maintained constant all the plant vital cycle long. The two applied grow conditions were applied to identify and understand the influence of heritable and non-heritable factors (epigenetic environmental factors) on pollen allergenicity. The mechanisms underlying the change in allergenicity were investigated by studying the qualitative and quantitative variations of the isoforms of the major ragweed allergen Amb a 1 with proteomic techniques. Before this experiment, ragweed populations were genetically characterized to define the origin of Italian populations and to confirm that the genetic variability is very high within populations but low among them. The results of these analyses indicated that ragweed Italian populations have a North America origin as the French ones and that all the populations investigated show, as expected, a high genetic variability among individuals and low among them.
The allergenicity of pollen was also variable among individuals and not significantly different among populations. The plant growth conditions determined the differences in the variability of allergenicity. Plants grown under controlled conditions produced pollen with similar allergenicity¬¬, while plants grown in standard conditions produced pollen with much more variable allergenicity. Electrophoresis and immunoblot analyses indicated that the variability in pollen allergenicity was mainly related to the pollen content of Amb a 1 allergen and not to a different expression and reactivity of its single principal isoforms. In conclusion, on the whole the results suggests that environmental factors (L, T, H) are responsible for the strong differences in pollen allergenicity and that these differences are not ascribed to differences in expression/reactivity of individual isoforms but to a quantitative differences involving all the considered isoforms.