Relevant bibliographies by topics / Amas hydrophobes

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Amas hydrophobes'

Author: Grafiati
Published: 25 May 2024

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Journal articles on the topic "Amas hydrophobes"

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Lim, San Sui, Cael O. Debono, Christopher A. MacRaild, et al. "Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening." Australian Journal of Chemistry 66, no. 12 (2013): 1530. http://dx.doi.org/10.1071/ch13266.

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Apical membrane antigen 1 (AMA1) is an essential component of the moving junction complex used by Plasmodium falciparum to invade human red blood cells. AMA1 has a conserved hydrophobic cleft that is the site of key interactions with the rhoptry neck protein complex. Our goal is to develop small molecule inhibitors of AMA1 with broad strain specificity, which we are pursuing using a fragment-based approach. In our screening campaign, we identified fragments that bind to the hydrophobic cleft with a hit rate of 5 %. The high hit rate observed strongly suggests that a druggable pocket is present
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Alam, Asrar. "Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1." Malaria Research and Treatment 2014 (December 18, 2014): 1–8. http://dx.doi.org/10.1155/2014/642391.

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Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a valuable vaccine candidate and exported on the merozoite surface at the time of erythrocyte invasion. PfAMA1 interacts with rhoptry neck protein PfRON2, a component of the rhoptry protein complex, which forms the tight junction at the time of invasion. Phage display studies have identified a 15-residue (F1) and a 20-residue (R1) peptide that bind to PfAMA1 and block the invasion of erythrocytes. Cocrystal structures of central region of PfAMA1 containing disulfide-linked clusters (domains I and II) with R1 peptide and a peptide deri
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Henderson, Kylie A., Victor A. Streltsov, Andrew M. Coley, et al. "Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain Recognition." Structure 15, no. 11 (2007): 1452–66. http://dx.doi.org/10.1016/j.str.2007.09.011.

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Harris, Karen S., Joanne L. Casey, Andrew M. Coley, et al. "Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1." Infection and Immunity 73, no. 10 (2005): 6981–89. http://dx.doi.org/10.1128/iai.73.10.6981-6989.2005.

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ABSTRACT Apical membrane antigen 1 (AMA1) is expressed in schizont-stage malaria parasites and sporozoites and is thought to be involved in the invasion of host red blood cells. AMA1 is an important vaccine candidate, as immunization with this antigen induces a protective immune response in rodent and monkey models of human malaria. Additionally, anti-AMA1 polyclonal and monoclonal antibodies inhibit parasite invasion in vitro. We have isolated a 20-residue peptide (R1) from a random peptide library that binds to native AMA1 as expressed by Plasmodium falciparum parasites. Binding of R1 peptid
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Bai, T., M. Becker, A. Gupta, et al. "Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket." Proceedings of the National Academy of Sciences 102, no. 36 (2005): 12736–41. http://dx.doi.org/10.1073/pnas.0501808102.

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Katsarou, Erasmia, Costas Charalambopoulos, and Nick Hadjiliadis. "Ternary Complexes of cis-(NH3)2PtCl2 (cis-DDP) With Guanosine (guo), Cytidine (cyd) and the Aminoacids Glycine (gly), L-Alanine (ala), L-2-Aminobutyric Acid (2-aba), L-Norvaline (nval) and L-Norleucine (nleu)." Metal-Based Drugs 4, no. 2 (1997): 57–63. http://dx.doi.org/10.1155/mbd.1997.57.

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The ternary complexes of formulae cis-[(NH3)2Pt(nucl)(amac)]NO3, where nucl = guo and cyd (guanosine and cytidine) and amac = the deprotonated aminoacids glycine (gly), L-alanine (ala), L-2-aminobutyric acid (2-aba), L-norvaline (nval) and L-norleucine (nleu), were prepared from the reactions of the binary chelated ones cis-[(NH3)2Pt(amac)]NO3 with the nucleosides.They were characterized by H1, C13 and Pt195 NMR and IR spectra, together with elemental analysis and conductivity measurements. The aminoacids coordinate with Pt(II) in the ternary complexes with their terminal -NH2 groups, guo thro
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Vetrivel, Umashankar, Shalini Muralikumar, B. Mahalakshmi, et al. "Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft ofToxoplasma gondiiApical Membrane Antigen 1 (AMA1)." Genomics & Informatics 14, no. 2 (2016): 53. http://dx.doi.org/10.5808/gi.2016.14.2.53.

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Hariyanti, Hariyanti, Kusmadi Kurmardi, Arry Yanuar та Hayun Hayun. "Ligand Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies of Asymmetrical Hexahydro-2H-Indazole Analogs of Curcumin (AIACs) to Discover Novel Estrogen Receptors Alpha (ERα) Inhibitor". Indonesian Journal of Chemistry 21, № 1 (2020): 137. http://dx.doi.org/10.22146/ijc.54745.

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The estrogen receptor alpha (ERα) plays an important role in breast development and pro-proliferation signal activation in the normal and cancerous breast. The ERα inhibitors were potentially active as cytotoxic agents against breast cancer. This study was conducted in order to find Asymmetrical Hexahydro-2H-Indazole Analogs of Curcumin (AIACs) as hits of ERα inhibitor. A training set of 17 selected ERα inhibitors was used to create 10 pharmacophore models using LigandScout 4.2. The pharmacophore models were validated using 383 active compounds as positive data and 20674 decoys as negative dat
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Moentamaria, Dwina, Zakijah Irfin, Achmad Chumaidi, and Heri Septya Kusuma. "Hydrophobic Support: A Phenomenon of Interface Lipase Activation in Polyurethane Foam as a Heterogeneous Biocatalyst in Synthesis of Natural Flavor Ester." Jurnal Teknik Kimia dan Lingkungan 6, no. 1 (2022): 27. http://dx.doi.org/10.33795/jtkl.v6i1.253.

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Biokatalis heterogen memerlukan penyangga yang sesuai melalui teknik imobilisasi enzim, terutama jika digunakan dalam industri makanan. Dalam sintesis perisa ester alami, busa poliuretan (PUF) dipilih sebagai penyangga imobilisasi lipase, karena memiliki sifat kaku inert, dan porositas tinggi. PUF perlu dilapisi dengan co-immobilized, yang terdiri dari campuran surfaktan yang aman yaitu gelatin, lecithin, PEG, MgCl2, sehingga menjadi satu kesatuan sebagai penyangga PUF hidrofobik. Interaksi hidrofobik antara lipase dan surfaktan pada PUF dapat memicu lipase yang mengaktifkan antarmuka untuk be
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Fathanah, Umi, Fachrul Razi, Mirna Rahmah Lubis, et al. "Modifikasi Membran Polyethersulfone dengan Penambahan Nanopartikel Mg(OH)2 dalam Pelarut Dimethyl Sulfoxide." ALCHEMY Jurnal Penelitian Kimia 18, no. 2 (2022): 165. http://dx.doi.org/10.20961/alchemy.18.2.58248.165-173.

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<p>Membran Polyethersulfone (PES) bersifat hidrofobik yang memiliki ketahanan rendah terhadap sifat fouling. Fouling pada membran mengakibatkan penurunan kinerja membrane selama proses operasi. Oleh karena itu, modifikasi membran perlu dilakukan untuk meningkatkan sifat hidrofilik membrane. Pada penelitian ini modifikasi dilakukan dengan penambahan nanopartikel Mg(OH)<sub>2</sub> yang bersifat tidak beracun, murah, dan mudah diperoleh. Penambahan aditif nanopartikel Mg(OH)<sub>2</sub> pada membran PES dilakukan dengan cara pencampuran polimer dengan metode <em&
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Dissertations / Theses on the topic "Amas hydrophobes"

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CANARD, LUC. "Analyse statistique des amas hydrophobes hca contenus dans les banques de sequences de proteines." Paris 6, 1997. http://www.theses.fr/1997PA066627.

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Les domaines proteiques globulaires de taille courante sont le resultat d'une separation quasiment parfaite entre la surface composee d'acides amines essentiellement hydrophiles, et le coeur, constitue par des acides amides amines hydrophobes. L'etude realisee a consiste dans un premier temps, a mettre en evidence la sur-representation et la sous-representation d'un certain nombre de classes d'amas hydrophobes au sens hca en comparant les nombres d'occurrences des amas dans des banques de sequences non redondantes a ceux obtenus dans des banques de sequences aleatoires de composition identique
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Dulin, Fabienne. "Exploration des caractéristiques tridimensionnelles des amas protéiques hydrophobes issus du formalisme "Hydrophobic Cluster Analysis" (HCA) : modélisation de formes oligomériques solubles du peptide Aβ impliqué dans la maladie d'Alzheimer, et identification d'un 'point chaud" commun à différentes protéines amyloïdes". Paris 6, 2006. http://www.theses.fr/2006PA066465.

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Nous avons d’abord exploré les caractéristiques 3D des amas d’acides aminés hydrophobes issus de la méthode "Hydrophobic Cluster Analysis" (HCA), au travers d’une représentation originale en tesselation de Voronoï. Chaque amas peut être ainsi caractérisé dans ses conformations  ou  et ses affinités préférentielles pour d’autres amas peuvent être décrites. Le repliement protéique peut alors être décrit comme l’assemblage de ces amas HCA 3D. Nous avons ensuite construit, en utilisant des outils d’alignement tels que HCA, des modèles 3D des formes oligomériques solubles du peptide A. Ce peptid
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Bruley, Apolline. "Exploitation de signatures des repliements protéiques pour décrire le continuum ordre/désordre au sein des protéomes." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS474.

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Une fraction significative des protéomes reste non annotée, laissant inaccessible une partie du répertoire fonctionnel de la vie, incluant des innovations moléculaires ayant une valeur thérapeutique ou environnementale. Le manque d'annotation fonctionnelle est en partie dû aux limites des approches actuelles pour la détection de relations cachées, ou à des caractéristiques spécifiques telles que le désordre. L'objectif de ma thèse a été de développer des approches méthodologiques reposant sur les signatures structurales des domaines repliés, afin de caractériser plus avant les séquences protéi
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Book chapters on the topic "Amas hydrophobes"

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Dey Sarkar, Sovik, and Chirantan Kar. "Cationic Amphiphiles as Antimicrobial Agents." In Recent Trends and The Future of Antimicrobial Agents - Part 2. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123975123010006.

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Numerous antimicrobial peptides (AMP) obtained from natural sources are currently tested in clinical or preclinical settings for treating infections triggered by antimicrobial-resistant bacteria. Several experiments with cyclic, linear and diastereomeric AMPs have proved that the geometry, along with the chemical properties of an AMP, is important for the microbiological activities of these compounds. It is understood that the combination of the hydrophobic and hydrophilic nature of AMPs is crucial for the adsorption and destruction of the bacterial membrane. However, the application of AMPs in therapeutics is still limited due to their poor pharmacokinetics, low bacteriological efficacy and overall high manufacturing costs. To overcome these problems, a variety of newly synthesized cationic amphiphiles have recently appeared, which imitate not only the amphiphilic nature but also the potent antibacterial activities of the AMPs with better pharmacokinetic properties and lesser in vitro toxicity. Thus, amphiphiles of this new genre have enough potential to deliver several antibacterial molecules in years to come.
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