Academic literature on the topic 'Alveolar bone regeneration'
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Journal articles on the topic "Alveolar bone regeneration"
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Funda, Goker, Silvio Taschieri, Giannì Aldo Bruno, Emma Grecchi, Savadori Paolo, Donati Girolamo, and Massimo Del Fabbro. "Nanotechnology Scaffolds for Alveolar Bone Regeneration." Materials 13, no. 1 (January 3, 2020): 201. http://dx.doi.org/10.3390/ma13010201.
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In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells. Due to their excellent physicochemical properties and biomimetic features, nanomaterials are attractive alternatives offering many advantages for stimulating cell growth and promoting tissue regeneration through tissue engineering. The main aim of this article was to review the currently available literature to provide an overview of the different nano-scale scaffolds as key factors of tissue engineering for alveolar bone regeneration procedures. In this narrative review, PubMed, Medline, Scopus and Cochrane electronic databases were searched using key words like “tissue engineering”, “regenerative medicine”, “alveolar bone defects”, “alveolar bone regeneration”, “nanomaterials”, “scaffolds”, “nanospheres” and “nanofibrous scaffolds”. No limitation regarding language, publication date and study design was set. Hand-searching of the reference list of identified articles was also undertaken. The aim of this article was to give a brief introduction to review the role of different nanoscaffolds for bone regeneration and the main focus was set to underline their role for alveolar bone regeneration procedures.
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Shimono, M., T. Inoue, and T. Yamamura. "Regeneration of Periodontal Tissues." Advances in Dental Research 2, no. 2 (November 1988): 223–27. http://dx.doi.org/10.1177/08959374880020020501.
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To elucidate the regenerative capability of the periodontal tissues, we carried out two experiments: (1) Regeneration of the gingival tissue following gingivectomy in rats. Ultrastructurally, regenerating junctional epithelium was similar in morphology to that of untreated animals and appeared to attach to the enamel after five days. Basal lamina and hemidesmosomes were produced faster at the enamel interface than at the connective tissue interface. Gingival tissue was completely regenerated seven days after the gingivectomy. (2) Regeneration of the cementum, periodontal ligament, and alveolar bone following intradentinal cavity preparation in dogs. In the early stages, the cavity was filled with an exudate and granulation tissue. Seven days after the operation, osteoblasts and cementoblasts were arranged regularly on the cut surface of the alveolar bone and dentin, respectively. Newly formed bone and cementum, and periodontal ligament grew to resemble pre-existing bone and cementum after 28-42 days. From these results, it is suggested that the periodontal tissues have an extremely high capability of regeneration.
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Mohd, Nurulhuda, Masfueh Razali, Mariyam Jameelah Ghazali, and Noor Hayaty Abu Kasim. "3D-Printed Hydroxyapatite and Tricalcium Phosphates-Based Scaffolds for Alveolar Bone Regeneration in Animal Models: A Scoping Review." Materials 15, no. 7 (April 2, 2022): 2621. http://dx.doi.org/10.3390/ma15072621.
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Three-dimensional-printed scaffolds have received greater attention as an attractive option compared to the conventional bone grafts for regeneration of alveolar bone defects. Hydroxyapatite and tricalcium phosphates have been used as biomaterials in the fabrication of 3D-printed scaffolds. This scoping review aimed to evaluate the potential of 3D-printed HA and calcium phosphates-based scaffolds on alveolar bone regeneration in animal models. The systematic search was conducted across four electronic databases: Ovid, Web of Science, PubMed and EBSCOHOST, based on PRISMA-ScR guidelines until November 2021. The inclusion criteria were: (i) animal models undergoing alveolar bone regenerative surgery, (ii) the intervention to regenerate or augment bone using 3D-printed hydroxyapatite or other calcium phosphate scaffolds and (iii) histological and microcomputed tomographic analyses of new bone formation and biological properties of 3D-printed hydroxyapatite or calcium phosphates. A total of ten studies were included in the review. All the studies showed promising results on new bone formation without any inflammatory reactions, regardless of the animal species. In conclusion, hydroxyapatite and tricalcium phosphates are feasible materials for 3D-printed scaffolds for alveolar bone regeneration and demonstrated bone regenerative potential in the oral cavity. However, further research is warranted to determine the scaffold material which mimics the gold standard of care for bone regeneration in the load-bearing areas, including the masticatory load of the oral cavity.
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Liu, Yanan, Haifeng Wang, Huixin Dou, Bin Tian, Le Li, Luyuan Jin, Zhenting Zhang, and Lei Hu. "Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect." Journal of Tissue Engineering 11 (January 2020): 204173142093037. http://dx.doi.org/10.1177/2041731420930379.
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Mesenchymal stem cells sheets have been verified as a promising non-scaffold strategy for bone regeneration. Alveolar bone marrow mesenchymal stem cells, derived from neural crest, have the character of easily obtained and strong multi-differential potential. However, the bone regenerative features of alveolar bone marrow mesenchymal stem cells sheets in the craniofacial region remain unclear. The purpose of the present study was to compare the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone (alveolar bone marrow mesenchymal stem cells) and iliac bone (Lon-bone marrow mesenchymal stem cells) in vitro and in vivo. Histology character, osteogenic differentiation, and osteogenic gene expression of human alveolar bone marrow mesenchymal stem cells and Lon-bone marrow mesenchymal stem cells were compared in vitro. The cell sheets were implanted in rabbit calvarial defects to evaluate tissue regeneration characteristics. Integrated bioinformatics analysis was used to reveal the specific gene and pathways expression profile of alveolar bone marrow mesenchymal stem cells. Our results showed that alveolar bone marrow mesenchymal stem cells had higher osteogenic differentiation than Lon-bone marrow mesenchymal stem cells. Although no obvious differences were found in the histological structure, fibronectin and integrin β1 expression between them, alveolar-bone marrow mesenchymal stem cells sheet exhibited higher mineral deposition and expression levels of osteogenic marker genes. After being transplanted in the rabbit calvarial defects area, the results showed that greater bone volume and trabecular thickness regeneration were found in bone marrow mesenchymal stem cells sheet group compared to Lon-bone marrow mesenchymal stem cells group at both 4 weeks and 8 weeks. Finally, datasets of bone marrow mesenchymal stem cells versus Lon-bone marrow mesenchymal stem cells, and periodontal ligament mesenchymal stem cells (another neural crest derived mesenchymal stem cells) versus umbilical cord mesenchymal stem cells were analyzed. Total 71 differential genes were identified by overlap between the 2 datasets. Homeobox genes, such as LHX8, MKX, PAX9, MSX, and HOX, were identified as the most significantly changed and would be potential specific genes in neural crest mesenchymal stem cells. In conclusion, the Al-bone marrow mesenchymal stem cells sheet-based tissue regeneration appears to be a promising strategy for craniofacial defect repair in future clinical applications.
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Urban, Istvan A., and Alberto Monje. "Guided Bone Regeneration in Alveolar Bone Reconstruction." Oral and Maxillofacial Surgery Clinics of North America 31, no. 2 (May 2019): 331–38. http://dx.doi.org/10.1016/j.coms.2019.01.003.
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Nishimura, Masahiro, Kazuma Takase, Fumio Suehiro, and Hiroshi Murata. "Candidates Cell Sources to Regenerate Alveolar Bone from Oral Tissue." International Journal of Dentistry 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/857192.
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Most of the cases of dental implant surgery, especially the bone defect extensively, are essential for alveolar ridge augmentation. As known as cell therapy exerts valuable effects on bone regeneration, numerous reports using various cells from body to regenerate bone have been published, including clinical reports. Mesenchymal cells that have osteogenic activity and have potential to be harvested from intra oral site might be a candidate cells to regenerate alveolar bone, even dentists have not been harvested the cells outside of mouth. This paper presents a summary of somatic cells in edentulous tissues which could subserve alveolar bone regeneration. The candidate tissues that might have differentiation potential as mesenchymal cells for bone regeneration are alveolar bone chip, bone marrow from alveolar bone, periosteal tissue, and gingival tissue. Understanding their phenotype consecutively will provide a rational approach for alveolar ridge augmentation.
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Dhande, Sharayu. "Localized Ridge Augmentation with Mandibular Block Autograft and Guided Bone Regeneration: A Case Report." Journal of Surgical Case Reports and Images 5, no. 2 (May 27, 2022): 01–05. http://dx.doi.org/10.31579/2690-1897/108.
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Numerous alveolar ridge defects resulted post extraction, long standing periodontal disease often require surgical intervention before prosthetic rehabilitation. On the other hand, alveolar bone defects affect the prognosis of dental implants and as a result, their reconstruction is must. Although a wide variety of options have been invented, autogenous bone is still the gold standard and has been yielding promising results. The authors report a case of localized alveolar ridge augmentation using autogenous chin block graft in conjunction with other bone substitutes for prosthetic rehabilitation of lower anterior region. Initially, the alveolar ridge was knife edge and the bone volume was insufficient for placement of dental implant. The CBCT analysis post 6 months shows significant increase in bone volume that was now suitable for prosthetic rehabilitation of the edentulous space.
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Sathishkumar, S., A. Meka, D. Dawson, N. House, W. Schaden, M. J. Novak, J. L. Ebersole, and L. Kesavalu. "Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration." Journal of Dental Research 87, no. 7 (July 2008): 687–91. http://dx.doi.org/10.1177/154405910808700703.
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Periodontal inflammation with alveolar bone resorption is a hallmark of periodontitis. We hypothesized that extracorporeal shock wave therapy (ESWT) could promote the regeneration of alveolar bone following Porphyromonas gingivalis-induced periodontitis in rats. Rats were infected with P. gingivalis for 10 wks, which caused alveolar bone resorption. The rats were then treated with a single episode of 100, 300, or 1000 impulses of shock wave on both cheeks at energy levels 0.1 mJ/mm2. Alveolar bone levels were determined at 0, 3, 6, and 12 wks following ESWT and compared with those in untreated controls. Infected rats treated with 300 and 1000 impulses demonstrated significantly improved alveolar bone levels at 3 wks compared with untreated controls, and the improved levels remained for at least 6 wks in most rats. The results demonstrated effective regeneration of alveolar bone by ESWT and suggested that ESWT should be evaluated as an adjunct in the regeneration of periodontal tissues following periodontal disease. Abbreviations: ESWT, extracorporeal shock wave therapy; PCR, polymerase chain-reaction.
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Li, Qi, Shuang Pan, Smit J. Dangaria, Gokul Gopinathan, Antonia Kolokythas, Shunli Chu, Yajun Geng, Yanmin Zhou, and Xianghong Luan. "Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation." BioMed Research International 2013 (March 26, 2013): 1–13. http://dx.doi.org/10.1155/2013/638043.
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In the present study we have determined the suitability of platelet-rich fibrin (PRF) as a complex scaffold for periodontal tissue regeneration. Replacing PRF with its major component fibrin increased mineralization in alveolar bone progenitors when compared to periodontal progenitors, suggesting that fibrin played a substantial role in PRF-induced osteogenic lineage differentiation. Moreover, there was a 3.6-fold increase in the early osteoblast transcription factor RUNX2 and a 3.1-fold reduction of the mineralization inhibitor MGP as a result of PRF application in alveolar bone progenitors, a trend not observed in periodontal progenitors. Subcutaneous implantation studies revealed that PRF readily integrated with surrounding tissues and was partially replaced with collagen fibers 2 weeks after implantation. Finally, clinical pilot studies in human patients documented an approximately 5 mm elevation of alveolar bone height in tandem with oral mucosal wound healing. Together, these studies suggest that PRF enhances osteogenic lineage differentiation of alveolar bone progenitors more than of periodontal progenitors by augmenting osteoblast differentiation, RUNX2 expression, and mineralized nodule formation via its principal component fibrin. They also document that PRF functions as a complex regenerative scaffold promoting both tissue-specific alveolar bone augmentation and surrounding periodontal soft tissue regeneration via progenitor-specific mechanisms.
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Apanasevich, V. I., E. K. Papynov, I. S. Afonin, I. O. Evdokimov, O. O. Shichalin, A. K. Stepanyugina, N. R. Pankratov, et al. "Dispersed biocomposite based on wollastonite/hydroxyapatite: Osteoplastic potential in terms of radiology." Pacific Medical Journal, no. 3 (September 28, 2020): 88–89. http://dx.doi.org/10.34215/1609-1175-2020-3-88-89.
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Objective: assessment of the bone tissue regeneration of alveolar ridge during implantation of biocomposite based on wollastonite/hydroxyapatite (HA) in the experiment.Methods: Four female rabbits were performed the extraction of lower left incisors under the general and local anesthesia followed by the augmentation with biocomposite. The results were assessed with cone beam computed tomography.Results: On the first day, the average density of bone structure of the alveolar socket was 37 HU; on the 60th day, it reached 1090 HU. The contour of the alveolar socket was not already visible on the 35th day. There were no signs of the osteolysis.Conclusions: The experiment result confirms the the participation of a CaSiO3/HA biocomposite in bone tissue regeneration, as evidenced by the dynamics of the increase in bone volume in the alveoli of the removed teeth of the lower jaw of experimental animals.
Dissertations / Theses on the topic "Alveolar bone regeneration"
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Alssum, Lamees. "Blood Perfusion and Wound Healing Following Alveolar Bone Regeneration Procedures." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1466587477.
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Sahlin-Platt, Annika. "Bone tissue regeneration indento-alveolar surgery : clinical and experimental studies on biomaterials and bone graft substitutes." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47418.
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Pathological processes in the alveolar and facial bones can lead to bone loss that may not heal with complete regeneration. Biomaterials can be used to facilitate the healing process and/or as a bone substitute, but the mechanisms are not fully understood. Persistent leakage of bacteria/bacterial toxins, after root canal treatment, may lead to a residual bone defect. The healing is dependent on a placed dental biomaterial providing a tight seal. The composition of the filling material may also influence the healing process. The general aim of this study is to investigate surface properties and biological interactions of biomaterials used in dento-alveolar surgery. A dental biomaterial, a bonded compomer (DAP) containing a corroding glass filler, was used as a root end filling material, promoting a new operation technique. The healing (assessed according to Molven´s x-ray criteria) demonstrates a significant improvement in healing results for the compomer group, compared to a commonly used technique. The surface properties and biological interactions of DAP were analyzed. ICP-OES of DAP cell culture medium extract demonstrated a significant release of Sr, Si and F from the dental biomaterial. Human periodontal ligament (PDL) cells grew on and around DAP specimens without any sign of toxic reactions. DAP extract stimulated proliferation of PDL cells, but caused an inhibition of osteoblastic gene expression in mouse bone marrow cells. The surface properties of the glass containing compomer may contribute to improved healing of the periapical lesions. A bovine inorganic bone graft substitute (BO) is commonly used as a treatment option in dento-alveolar surgery with new bone formation in immediate close contact with BO material. ICP-OES dissolution analysis of cell culture media, after incubation with BO particles, demonstrated a dosedependent release of Si and a decrease of Ca and P. An uptake of Ca from the medium to the BO particle was demonstrated with calcium-45 labeling. The Si dissolution varied between different batches, possibly reflecting a variation in food intake in the animals. Stimulated osteogenic response was seen in close contact to the BO particles in cell cultures. Furthermore, it was clearly demonstrated that the study design is a critical factor for correctly understanding biomaterials’ biological interactions. The surface properties of three bone graft substitutes reported to have good results in dento-alveolar surgery were investigated, in order to establish whether or not dissolution-precipitation reactions could contribute to the bone healing. Dissolution-precipitation extracts of BO, bioactive glass 45S5 (BG) and a marine algae hydroxyl apatite (AP) in cell culture media were analyzed. Dissolution of Si at significant levels was detected for BO and 45S5 over time. Significant uptake levels of Ca and P from the culture were seen for both 45S5, BO and AP but at different times. Surface analysis of the biomaterials with SEM/EDAX, before and after immersion in cell culture media, revealed a smoothing of the surface morphology for 45S5 over time. No obvious alterations for BO and AP were detected. Ca/P ratio decreased significantly for 45S5, but no major changes were detected by XPS for BO or AP. XPS further demonstrated a surface charge for BO, changing from negatively to positively charged when exposed to serum. 45S5 and AP had positive surface charges, both in the absence and the presence of serum. These demonstrated surface changes in biomaterials could contribute to adherence of cells and subsequently affect bone healing. Conclusion: Biomaterials used in dento-alveolar surgery interact with biological surroundings through surface and dissolution-precipitation reactions which may have implications for bone healing.
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Hariri, Firdaus. "Alveolar distraction osteogenesis for dental implant rehabilitation inreconstructed jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661514.
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Zamparini, Fausto <1988>. "Peri-Implant And Periapical Oral Bone Defects: Clinical Strategies To Achieve Alveolar Bone Stability And Experimental Bone Regeneration Procedures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/9102/1/Tesi%20Zamparini%20revised%206.11.19.pdf.
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Peri implant and periapical bone defects are widespread in the world population. Considering the high number of implant placement and root canal treatment performed every year, resolution of these bone defects will be of predominant interest in the next future.
The present project has several aims:
The first part of the project aimed to investigate how and what factors affect peri implant bone remodeling process. Microchemical analysis of the peri implant bone interface of retrieved human dental implants was performed. In addition, prospective clinical studies were conducted to evaluate the factors mostly related to peri implant bone loss.
The second part of the project aimed to evaluate chemical physical and micromorphological properties of hydraulic calcium silicates based materials (CaSi), which gained a particular attention in the endodontic field. Use of these materials claimed to resolve several complex endodontic complications, however few information is present in literature. These materials were compared with some “gold standard” bioinert materials.
Given the attractive biointeractive properties of CaSi based materials, the last part of the study will focus on the design and characterization of new mineral based scaffolds, aimed to be applied in future bone regeneration procedures. Scaffolds, composed of a polymeric matrix were doped with CaSi and calcium phosphates, in order to increase the materials biointeractive properties. A complete characterization of their chemical-physical-mechanical-thermal properties was performed, as well as the evaluation of apatite forming ability (bioactivity) and biocompatibility of these mineral based scaffolds. The combination of Human Periapical-cysts Mesenchymal Stem Cells (hPC-MSC) as a potential strategy to achieve periapical bone regeneration was evaluated. Finally, the angiogenesis potential of these scaffolds was investigated through the growth and proliferation of porcine vascular wall mesenchymal stem cells (pvw-MSC) was performed.
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Lozano-Carrascal, Naroa. "Topical Application of Bisphosphonates to Enhance Alveolar New Bone Formation." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/456485.
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This PhD thesis is a compendium of three publications, which sets out to broaden our knowledge and understanding of the topical application of bisphosphonates alone or mixed with a bone graft in alveolar bone defects, to evaluate the potential capacity of them to preserve/enhance alveolar new bone formation.
In recent years, research has focused on improving bone substitutes to achieve faster and better regeneration by morphologic and biochemical modification. Bisphosphonates are a group of drugs that reduce bone resorption by inhibiting the formation, recruitment activity of mature osteoclasts; and promoting their apoptosis. In addition, some bisphosphonates enhance osteoblast differentiation and activity. Thence, it has been demonstrated that topical application of a bisphosphonates can minimize the bone resorption following muco-periostial flap surgery or in peri-
implantitis; improve the osteoconductive and regenerative capacity of a biomaterial; prevent the surface resorption of onlay bone grafts; or reduce post-extraction dimensional changes.
Mandibular second premolars (P2) and first molars (M1) were extracted from six Fox-Hound dogs. P2 were categorized as small defects (SD) and M1 as large defects (LD). Four random groups were created: SC (small control defects with MP3®), ST (small test defects MP3® + pamidronate), LC (large control defects with MP3®), and LT (large test defects MP3® + pamidronate). At four and eight weeks of healing the percentages of new bone formation (NB), residual grafts (RG) and connective tissue (CT) were analysed by histology and histomorphometric analysis. To complement the information already obtained from histological analysis, the samples were evaluated through scanning electron microscopy (SEM), and Energy dispersive X-ray spectroscopy (EDX), to identify the chemical elements present into the biomaterial and surrounding tissues, for understanding the biomaterial’s degradation process. The study was complemented with a systemic literature review of the articles published between January 2000 and December 2016, that evaluated in vivo the effects of the topical application of bisphosphonates on bone regeneration/preservation in alveolar defects. A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis.
Histomorphometric and histologic analysis of the present pilot study demonstrated that after 4 and 8 weeks of healing, higher new bone formation for test groups (ST and LT) treated topically with pamidronate, compared with SC and LC respectively; residual graft was significantly higher in both control groups (SC and LC) compared to test (ST and LT) groups; and connective tissue percentage was higher in large defects (LC and LT) compared to small defects (SC and ST). SEM analysis revealed more mineralized bone in test groups (ST and LT) compared with control groups, demonstrated by higher percentages of Ca obtained from EDX spectroscopy.
Within the limitations of this experimental study, the findings suggest that porcine xenografts (MP3®) modified with pamidronate favours the new bone formation and increased the porcine xenograft substitution/replacement after 4 and 8 weeks of healing. These results are in accordance with the conclusions obtained from the systematic review. Despite the comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, the topical application of bisphosphonate solution would appear to favour new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density.
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Chambrone, Daniela. "Estudo clínico randomizada, duplo cego, do efeito do tratamento de defeitos infra-ósseos com a proteína da matriz do esmalte.Resultados após dois anos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-11042008-113921/.
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O objetivo deste trabalho foi comparar os parâmetros clínicos periodontais após tratamento de defeitos infra-ósseos com retalho de espessura total (RET) associado ou não à proteína da matriz do esmalte (PME). Foram selecionados 10 pacientes com saúde geral boa, apresentando periodontite crônica e com um par ou mais de defeitos infra-ósseos (PCS >= 6 mm), totalizando 38 defeitos. Todos os pacientes receberam instruções de higiene bucal, raspagem e alisamento radicular, prévio a cirurgia. Foram divididos em dois grupos: grupo PME recebeu retalho de espessura total associado à proteína da matriz do esmalte; e o grupo RET recebeu apenas retalho de espessura total. Todos os pacientes passaram por sessões de controle e manutenção bucal a cada 3 meses, até o final do experimento. Após 24 meses observamos redução na média da PCS de 4,21 mm (PME) e 3,28 mm (RET),do início ao final do experimento, resultado significativo para ambos os grupos (p < 0,001), entretanto, o PME mostrou redução da PCS estatisticamente superior ao RET, aos 24 meses (p = 0,030). Para o NCIR o ganho médio foi de 5,69 mm (PME) e de 5,24 mm (RET), sendo esses ganhos significativos para ambos os grupos (p < 0,001) comparados o início ao final do experimento, no entanto, não houve diferença significativa quando comparadas às médias entre os dois grupos, ao final do trabalho (p = 0,59). Com relação ao IP, foi detectada uma redução significativa nos dois grupos ao longo do tratamento (p=0,022 para PME; p=0,005 para RET), 60% para o grupo PME e 80% para o grupo RET, sem contudo ser observada uma diferença estatisticamente significante entre os grupos (p=0,46). Quando observado o IG, tanto no PME como no RET, foi detectada uma redução significativa ao longo do experimento (p<0,001), entretanto, não houve diferença significativa entre os grupos em nenhum momento do experimento (p=0,34). A RG foi maior para o PME do que para o RET (p<0,001), sendo que no PME a RG aumentou 1,02 mm, apesar desse resultado, os valores médios de retração gengival não foram diferentes estatisticamente quando comparadas entre os grupos (p=0,68). Não houve alteração significativa na quantidade de gengiva queratinizada no PME (p = 0,23), enquanto no RET houve uma redução significativa na faixa de gengiva queratinizada ao longo do tempo de 0,78 mm (p=0,010), sem diferença estatística significante entre os grupos. A mobilidade dental não sofreu mudanças ao longo do tempo em ambos os grupo (p=0,90). Concluímos que o tratamento de defeitos infra-ósseos periodontais através da associação da proteína da matriz do esmalte com o retalho de espessura total reposto resulta em maior redução da profundidade clínica de sondagem quando comparado ao uso do retalho de espessura total reposto, após 24 meses.The aim of the present clinical trial was to compare the periodontal clinical parameters after the treatment of intrabony defects with open flap debridement (OFD) with or without enamel matrix derivative (EMD). Ten subjects with good health, chronic periodontite and one or more pair of the intrabony defects (PPD >= 6 mm), totalizing 38 defects. All the patients received instructions of buccal hygiene, scaling and root planning, previous surgery. They were divided into two groups: group PME received open flap debridement associated to the enamel matrix protein; and the group OFD just received open flap debridement. All the patients passed by control sessions and buccal maintenance every 3 months, until the experiment end. After 24 months, a mean reduction of PPD was 4,21 mm (EMD) and 3,28 mm (OFD), beginning at the end of the experiment, significant result for both groups (p < 0,001), however, EMD showed PPD reduction statistically superior to OFD, at 24 months (p = 0,030). For the relative attachment level (RAL) the mean gain was 5,69 mm (EMD) and 5,24 mm (OFD), being these significant for both groups (p < 0,001) compared the beginning at the end of the experiment, however, there was not significant difference when compared to the means between both groups, at the end of the work (p = 0,59). With regard to PI, it was detected a significant reduction in the two groups along the treatment (p=0,022 to EMD; P=0,005 to OFD), 60% to the group EMD and 80% to the group OFD, without however a statistically significant difference between groups be observed (p=0,46). When observed GI, so much in the EMD as in OFP, it was detected a significant reduction along the experiment (p<0,001), however, there was not significant difference between groups in no experiment moment (p=0,34). RG was larger for EMD than for OFP (p<0,001), for EMD increased 1,02 mm, although of this result, the mean values of GR were not different statistically when compared between groups (p=0,68). There was not significant alteration in the keratinized tissue quantity in EMD (p = 0,23), while in the OFD there was a significant reduction in the keratinized tissue band along time of 0,78 mm (p=0,010), without differentiating significant statistics between groups. The dental mobility did not suffer changes along time in both group (p=0,90). In conclusion, the intra-bony periodontal defects treatment through the enamel matrix protein association with the open flap debridement results in more reduction to the probing clinical depth when compared to the open flap debridement, after 24 months.
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Ramirez, German Omar. "The role of prostaglandin E₂ on the alveolar bone turnover in the rat mandible /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19132.pdf.
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Colli, Vilma Clemi [UNESP]. "Análise da ação da ocitocina sobre a remodelação óssea alveolar em ratas wistar de 12, 18 e 24 meses." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/100955.
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colli_vc_dr_araca.pdf: 1176842 bytes, checksum: 7b5e4f64a86568d1041b8b5218994711 (MD5)A ação da ocitocina (OT) como regulador direto da massa óssea foi reportada em roedores jovens e este efeito anabólico foi atribuído à ação periférica deste hormônio. O objetivo deste estudo foi investigar a ação periférica de OT no processo de reparo alveolar de ratas Wistar de 12, 18 e 24 meses. Ratas de 12 meses com ciclo estral normal e ratas de 18 e 24 meses em diestro permanente receberam duas injeções intra-peritoniais (12 horas de intervalo) de salina (NaCl 0,15M – grupos controle) ou OT (134g/Kg – grupos tratados). Sete dias após, o incisivo direito foi extraído e as análises foram realizadas com 28 dias de reparo alveolar (35 dias após administração de salina ou OT). Os resultados plasmáticos de cálcio e fósforo não diferiram entre os grupos. Os marcadores bioquímicos sistêmicos de formação óssea, fosfatase alcalina (FAL) e osteocalcina (OC), não revelaram diferença significativa de valores na comparação entre grupos controle e tratado de 12 meses, porém esta diferença foi significativa para os dois marcadores quando os animais tratados de 18 e 24 meses foram comparados com os respectivos controles. A análise histomorfométrica e a reação de imunohistoquímica contra OC confirmaram estes resultados mostrando que o tratamento com OT, promoveu maior formação óssea nos animais de 18 e 24 meses. O marcador sistêmico de reabsorção óssea, fosfatase ácida resistente ao tartarato (TRAP) não foi estatisticamente diferente entre animais dos grupos controle e tratado de 12 e 18 meses, porém nos de 24 meses este valor foi significativamente menor nos animais tratados indicando diminuição de reabsorção por ação de OT nos animais desta idade. A imunomarcação para TRAP realizada nos cortes alveolares confirmou os...
The action of oxytocin (OT) as a direct regulator of bone mass has been reported in young rodents and this anabolic effect was attributed to the peripheral action of this hormone. The aim of this study was to investigate the peripheral action of OT in the process of alveolar repair of Wistar rats with 12, 18 and 24 months. Rats of 12 months with normal estrous cycle and rats with 18 and 24 months in permanent diestrus received two intra-peritoneal injections (12 hours apart) of saline (NaCl 0.15 M - control group) or OT (134 g / kg - treated groups). Seven days later, the right incisor was extracted and the analyzes were performed with 28 days of alveolar repair (35 days after administration of saline or OT). The plasma results of calcium and phosphorus did not differ between groups. The systemic biochemical bone formation markers, alkaline phosphatase (ALP) and osteocalcin (OC), revealed no significant difference of values in animals of 12 months, but this difference was significant for both markers when treated animals of 18 and 24 months were compared to controls. The histomorphometric analysis and immunohistochemical reaction against osteocalcin confirmed these results showing that treatment with OT, promoted greater bone formation in animals with 18 and 24 months. The systemic marker of bone resorption, tartrate-resistant acid phosphatase (TRAP) was not statistically different between animals of the control and treated groups of 12 and 18 months, but in 24 months the values were significantly lower in treated animals indicating decreased resorption action of OT in animals of this age. The immunostaining for TRAP performed on alveolar cuts confirmed the results of the results of systemic markers in groups of 12 and 24 months... (Complete abstract click electronic access below)
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Colli, Vilma Clemi. "Análise da ação da ocitocina sobre a remodelação óssea alveolar em ratas wistar de 12, 18 e 24 meses /." Araçatuba, 2012. http://hdl.handle.net/11449/100955.
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Orientador: Rita Cássia Menegati DornellesCoorientador: Poli Mara Spritzer
Banca: João Cesar Bedran de Castro
Banca: Roberta Okamoto
Banca: Keico Okino Nonaka
Banca: Marcelo Alves da Silva Mori
Resumo: A ação da ocitocina (OT) como regulador direto da massa óssea foi reportada em roedores jovens e este efeito anabólico foi atribuído à ação periférica deste hormônio. O objetivo deste estudo foi investigar a ação periférica de OT no processo de reparo alveolar de ratas Wistar de 12, 18 e 24 meses. Ratas de 12 meses com ciclo estral normal e ratas de 18 e 24 meses em diestro permanente receberam duas injeções intra-peritoniais (12 horas de intervalo) de salina (NaCl 0,15M - grupos controle) ou OT (134g/Kg - grupos tratados). Sete dias após, o incisivo direito foi extraído e as análises foram realizadas com 28 dias de reparo alveolar (35 dias após administração de salina ou OT). Os resultados plasmáticos de cálcio e fósforo não diferiram entre os grupos. Os marcadores bioquímicos sistêmicos de formação óssea, fosfatase alcalina (FAL) e osteocalcina (OC), não revelaram diferença significativa de valores na comparação entre grupos controle e tratado de 12 meses, porém esta diferença foi significativa para os dois marcadores quando os animais tratados de 18 e 24 meses foram comparados com os respectivos controles. A análise histomorfométrica e a reação de imunohistoquímica contra OC confirmaram estes resultados mostrando que o tratamento com OT, promoveu maior formação óssea nos animais de 18 e 24 meses. O marcador sistêmico de reabsorção óssea, fosfatase ácida resistente ao tartarato (TRAP) não foi estatisticamente diferente entre animais dos grupos controle e tratado de 12 e 18 meses, porém nos de 24 meses este valor foi significativamente menor nos animais tratados indicando diminuição de reabsorção por ação de OT nos animais desta idade. A imunomarcação para TRAP realizada nos cortes alveolares confirmou os... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The action of oxytocin (OT) as a direct regulator of bone mass has been reported in young rodents and this anabolic effect was attributed to the peripheral action of this hormone. The aim of this study was to investigate the peripheral action of OT in the process of alveolar repair of Wistar rats with 12, 18 and 24 months. Rats of 12 months with normal estrous cycle and rats with 18 and 24 months in permanent diestrus received two intra-peritoneal injections (12 hours apart) of saline (NaCl 0.15 M - control group) or OT (134 g / kg - treated groups). Seven days later, the right incisor was extracted and the analyzes were performed with 28 days of alveolar repair (35 days after administration of saline or OT). The plasma results of calcium and phosphorus did not differ between groups. The systemic biochemical bone formation markers, alkaline phosphatase (ALP) and osteocalcin (OC), revealed no significant difference of values in animals of 12 months, but this difference was significant for both markers when treated animals of 18 and 24 months were compared to controls. The histomorphometric analysis and immunohistochemical reaction against osteocalcin confirmed these results showing that treatment with OT, promoted greater bone formation in animals with 18 and 24 months. The systemic marker of bone resorption, tartrate-resistant acid phosphatase (TRAP) was not statistically different between animals of the control and treated groups of 12 and 18 months, but in 24 months the values were significantly lower in treated animals indicating decreased resorption action of OT in animals of this age. The immunostaining for TRAP performed on alveolar cuts confirmed the results of the results of systemic markers in groups of 12 and 24 months... (Complete abstract click electronic access below)
Doutor
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Glazier, Thomas F., Thomas C. Waldrop, John C. Gunsolley, and Robert Sabatini. "The Role of Leukocyte-Platelet Rich Fibrin in Human Alveolar Ridge Preservation: A Randomized Clinical Trial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3735.
Full textAbstract:
PURPOSE: The aim of this study is to examine the healing of intact extraction sockets grafted with leukocyte-platelet rich fibrin (L-PRF) as compared to sockets grafted with freeze-dried bone allograft (FDBA) and a resorbable collagen barrier membrane (RCM).
METHODS: This prospective randomized, examiner blinded pilot study included 17 subjects randomized to two treatment groups. Serum total cholesterol, low density lipoprotein (LDL), 25-hydroxyvitamin-D3, and platelet counts were determined preoperatively in all subjects. The experimental arm consisted of 8 posterior tooth-bounded intact extraction sites receiving L-PRF plugs. The control group consisted of 9 posterior tooth-bounded intact extraction sites receiving FDBA and RCM. An acrylic stent was fabricated to take duplicate clinical and CBCT measurements immediately post-extraction and at time of implant placement. A repeat-measures analysis of variance was utilized for statistical analysis.
RESULTS: The study failed to detect a clinical or radiographic difference between treatment groups in horizontal or vertical ridge dimension changes. Serum cholesterol, LDL, 25-hydroxyvitamin-D3, and buccal plate thickness had a non-significant effect on outcome measurements, although there was a high prevalence of hyperlidpidemia and hypovitaminosis in the study population.
CONCLUSIONS: The alveolar ridge dimension changes in intact posterior extraction sockets may be similar when either L-PRF or FDBA and RCM are utilized as socket grafting material. Although there was a high prevalence of high cholesterol and low 25-hydroxyvitamin-D3 levels in the population, this study failed to detect a significant correlation between preoperative serum levels and postoperative ridge dimension changes.
Books on the topic "Alveolar bone regeneration"
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T, Jensen Ole, ed. The osteoperiosteal flap: A simplified approach to alveolar bone reconstruction. Hanover Park, IL: Quintessence Pub., 2009.
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Lang, Niklaus Peter, William V. Giannobile, and Maurizio S. Tonetti. Osteology guidelines for oral and maxillofacial regeneration: Clinical research. London: Quintessence Publishing, 2014.
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Osteology guidelines for oral and maxillofacial regeneration: Preclinical models for translational research. London: Quintessence Pub, 2011.
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Jensen, Ole T. Alveolar Distraction Osteogenesis. Quintessence Publishing (IL), 2002.
Find full textBook chapters on the topic "Alveolar bone regeneration"
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Muthusubramanian, Veerabahu, and Kalarikkal Mukundan Harish. "Alveolar Bone Grafting." In Oral and Maxillofacial Surgery for the Clinician, 1655–73. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_74.
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AbstractAlveolar Bone Grafting is a clinical procedure which is performed to maintain the integrity of the alveolar arch in cleft patients. This clinical procedure helps in facilitating eruption of canine and lateral incisors. This chapter discusses the normal anatomy of alveolus, significance of cleft alveolus, surgical steps to ensure separation of a well-defined oral and nasal layer, donor sites for bone grafting, harvesting techniques and final closure of the alveolar cleft. In addition, this chapter further highlights the recent developments in the field of bone regeneration.
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Sybil, Deborah, Shubham Datta, and Uqba Raza. "Injectable Biomaterials for Alveolar Bone Regeneration." In Engineering Materials for Stem Cell Regeneration, 163–80. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4420-7_7.
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Reynolds, Mark A., Zeqing Zhao, Michael D. Weir, Tao Ma, Jin Liu, Hockin H. K. Xu, and Abraham Schneider. "Nanopharmaceuticals in Alveolar Bone and Periodontal Regeneration." In Nanopharmaceuticals in Regenerative Medicine, 269–88. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003153504-15.
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Kumar, Vinay V., Supriya Ebenezer, and Andreas Thor. "Bone Augmentation Procedures in Implantology." In Oral and Maxillofacial Surgery for the Clinician, 407–26. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_19.
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AbstractSuccessful implant dentistry mandates implants to be placed in an appropriate three-dimensional manner that supports the prosthesis adequately. Due to the resorption patterns of edentulous jaws, the ideal position of implants required varying amounts of bone augmentation. Commonly carried out bone-augmentation procedures are Guided Bone Regeneration, onlay bone grafting and sinus floor elevation. This chapter discusses the resorption pattern of edentulous jaws, the biology of alveolar bone of relevance to the maxillofacial surgeon, the biomaterials used for augmentation and the commonly carried out augmentation procedures.
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Fagan, Mark C., Gregory J. Conte, and Richard T. Kao. "Management of Complications of Guided Bone Regeneration." In Horizontal Alveolar Ridge Augmentation in Implant Dentistry: A Surgical Manual, 120–24. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119019916.ch12.
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Pirih, Flavia Q., and Paulo M. Camargo. "Dental Implant Site Development with Particulate Bone Grafts and Guided Bone Regeneration." In Vertical Alveolar Ridge Augmentation in Implant dentistry : A Surgical Manual, 79–92. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119082835.ch09.
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Nagasawa, A., and K. Kato. "Bone Regeneration Effect of Argon Laser in Alveolar Laser Surgery." In Laser in der Medizin / Laser in Medicine, 300–303. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-50234-7_75.
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Weinreb, Miron, Igor Tsesis, Eyal Rosen, Silvio Taschieri, Massimo Del Fabbro, and Carlos E. Nemcovsky. "Evolving New Strategies for Periodontal, Endodontic, and Alveolar Bone Regeneration." In Evidence-Based Decision Making in Dentistry, 109–37. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45733-8_8.
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Takahashi, Tetsu, and Kensuke Yamauchi. "Vertical Augmentation of the Alveolar Ridge with Titanium-Reinforced Devices (Protected Bone Regeneration)." In Vertical Alveolar Ridge Augmentation in Implant dentistry : A Surgical Manual, 93–109. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119082835.ch10.
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Marei, Mona, Mohamad Nageeb, Rania M. Elbackly, Manal M. Saad, Ahmad Rashad, and Samer H. Zaky. "Tissue Engineering Alveolar Bone." In Regenerative Dentistry, 19–81. Cham: Springer International Publishing, 2010. http://dx.doi.org/10.1007/978-3-031-02581-5_2.
Full textConference papers on the topic "Alveolar bone regeneration"
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KOTH, Valesca, Gabriel RUBENSAM, Bernardo Ottoni Braga BARREIRO, Thaynã Spencer STEIN, and Karen CHERUBINI. "TOTAL CONTENT OF CALCIUM AND PHOSPHORUS IN SERUM OF WISTAR RATS BY AN OPTIMIZED METHOD OF ICP-MS." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.27_abstract_koth.pdf.
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In the Odontology field, the modeling process of alveolar bone has been a topic of investigation for the last years since the lost bone after tooth extraction can preclude aesthetic and function. In this practice, the volume of the tissue to be modeled depends on, among other factors, the serum levels of calcium and phosphorus, and it is of interest to monitor these elements to better understand the mechanism of tissue regeneration. These elements are routinely analyzed for clinical purposes, as serum constituents, by UV-VIS spectrophotometry after chromogenic reactions for each metal with different reagents. Depending on the analytical demands and work objectives, it is necessary to have methods based on technologies that allow multi-element quantification in a single experiment. In this context, ICP-MS has been considered a powerful tool for rapid multi-element analysis due to its high selectivity and sensitivity. However, it has been reported that samples with high content of salts and proteins, such as serum samples, cause matrix-induced interferences due to weak sample preparation and the presence of polyatomic ions. The present study aimed to identify and mitigate matrix effects in rat serum samples during the simultaneous quantification of calcium and phosphate using ICP-MS and evaluate its capability of differentiating element levels from Wistar rats subjected to tooth extraction with and without alveolar bone grafting. In addition, the optimized method can be used for more comprehensive mineralomics studies related to the bone modeling process in future studies.