Journal articles on the topic 'Alta Manufacturing Co'

Supercritical extraction (SFE) is a unit operation that exploits the dissolving power of supercritical fluids (SF) under conditions above their critical temperature and pressure. It is possible to obtain solvent-free extracts using SF and the extraction is faster than using conventional organic solvents. These advantages are due to the high volatility of SF (gases under normal environmental conditions) and improved transport properties (i.e., high diffusivity and low viscosity). When using carbon diox ide (CO,) in particular, moderate-temperature processing and high selectivity towards valuable microconstituents in natural products can be achieved. This article presents a review of transport properties and solubilities in SF, particularly CO2, as well as other underlying factors that are respon sible for the kinetics and phase equilibrium in SFE processes. It also describes the selective CO 2 ex traction of essential oils, pungent principles, carotenoid pigments, antioxidants, antimicrobials, and related substances to be used as ingredients for the food, drug and perfume industries, from spices, herbs and other plant materials. These very important applications are discussed from the point of view of the potential applications of SFE in Latin America. The two most important commercial ap plications of SFE in the food industry, namely hop extraction and coffee decaffeination, are reviewed to a limited extent. Some other potential applications briefly described include extraction and frac tionation of edible fats and oils, purification of solid matrices, and concentration of fermentation broths, fruit juices and other extracts. In most cases CO2 extracts are compared with counterparts obtained using conventional methods.

Results of processing and characterization of Cu(In,Ga)Se2 (CIGS) thin films growth by thermal co-evaporation with adequate physical properties to be used in solar cells are presented in this work. Cadmium Sulfide (CdS) as window material with 40 nm of thickness were deposited by chemical bath deposition (CBD) technique. A Molybdenum (Mo) layer was deposited as back contact on CIGS solar cells. Different CIGS thin films were processed by a simplified co-evaporation technique and revealed a good polycrystalline quality with an alfa-chalcopyrite phase. The stoichiometry of the CIGS thin films can be accurately controlled using a fully automated single vacuum photovoltaics manufacturing system. Automated system operations (ASO) is the set of software and hardware that allows computer systems, network devices or machines to function without any manual intervention. ASOs allow computer systems to work without a human operator physically located at the site where the system is installed. CIGS solar cells fabricated in this work, showed photovoltaic efficiencies close to 11 %.

Le istanze di una didattica trasformativa incentrata sulle competenze trasversali di sostenibilità impongono una profonda riconsiderazione dei processi valutativi, auspicata dagli organismi internazionali di ricerca, anche alla luce delle dinamiche squisitamente democratiche e sotto il segno della corresponsabilità educativa che rappresentano le più efficaci e feconde risposte all'emergenza pandemica. Il costrutto di "equità agentiva", proposto nel contesto di ricerche transdisciplinari a impronta neuroscientifica, disegna un saliente connotato delle pratiche co-costruite dalle microcomunità di ricerca germinanti in seno ai sistemi educativi. I processi autenticamente co-valutativi costituiscono un essenziale tassello di una relazione di insegnamento-apprendimento votata alla ridefinizione del senso di sé, degli altri e dell'ecosistema in cui si è immersi. Apprezzando metodologicamente le opportunità situazionali e informali, tali processi acquisiscono generativa consistenza in una dimensione strutturalmente transizionale, caratterizzata dall'ascolto attivo e dalla proattiva apertura alla trasformazione 

In sostanziale accordo con la rivisitazione del concetto di "rimozione primaria" proposta da Jasminka Suljacic, in questa nota si sostiene l'ipotesi di una sia pur parziale quota di contenuti nel rimosso primario che derivi non solo dalla generica immaturità dell'apparato neurobiologi-co, come suggeriscono le attuali ricerche delle neuroscienze; ma da operazioni difensive preco-ci, quali ad esempio le protofantasie secondo Gaddini. In tale prospettiva, non dobbiamo rinunciare alla interpretazione di transfert a questi livelli; seppure, certamente, si tratta di una in-terpretazione che deve essere modulata e adattata ad ogni singola situazione.

Génie la matta è un romanzo lucido e tagliente, poetico ed evocativo. È la storia di Marie, una bambina nata dallo stupro subito dalla madre, e che soffrirà lei stessa. Un'amara storia di trasmissione transgenerazionale maligna. Respinta, insieme alla madre, da tutta, o quasi, la co-munità in cui vive, Marie racconta il muro di silenzio che si innalza tra l'individuo e gli altri, dove l'assenza di parola e la sordità si incontrano.

I rapporti tra valutazione ed autodirezione meritano una rinnovata attenzione anche in considerazione dell'utilizzo crescente delle tecnologie in qualunque contesto educativo-formativo formale, non formale e informale. A partire da tale evidenza lo studio si interroga sui riflessi di tale rapporto con specifico riferimento alla didattica universitaria, che chiama in causa una pluralità di attori sociali. Un processo che la pandemia ha sollecitato in modo spontaneo a causa della situazione emergenziale, e che oggi merita di essere analizzato e valorizzato negli aspetti capaci di determinare vantaggi nel processo dell'insegnare e dell'apprendere sul duplice piano dell'autonomia degli studenti, della loro partecipazione attiva e della co-responsabilità nel conseguimento dei risultati attesi

Negli ultimi anni, la ricerca sugli esiti della valutazione ha mostrato evidenze che dimostrerebbero alcune relazioni tra i risultati di apprendimento degli studenti e gli strumenti di valutazione utilizzati nelle scuole. Il paper presenta un insieme di ricerche sulla valutazione formativa, focalizzandosi sulla prospettiva del feedback. A partire da questa prima analisi, vengono spiegati ulteriori aspetti di sviluppo che portano a considerare i significati della valutazione narrativa e trasformativa. Questo particolare processo di valutazione mostra una maggiore equità nei risultati dell'apprendimento e una prospettiva più esplicita sulla prassi democratica nelle scuole. Il caso di studio esplorativo presentato ha utilizzato il costrutto teorico iniziale di questo articolo. Attraverso un modello di ricerca-formazione-intervento, il caso studio mostra possibili e interessanti sviluppi della collegialità. Il percorso, iniziato nel 2018 e tuttora in corso, ha attraversato la pandemia, e permesso di affrontare l'emergenza educativa partendo dalla valutazione. L'attenzione è rivolta alla supervisione accademica come un modo per sostenere l'innovazione e il cambiamento organizzativo.

Il lavoro evidenzia la necessità di riflettere sui modelli identificatori individuali che sottendono alla formazione dello psicoterapeuta della coppia e della famiglia. Processi complessi difficili da precisare ma che meritano grande attenzione. L'allievo che ha già una formazione personale psicoanalitica deve sottoporsi ad un doppio lutto, quello dei modelli teorici della psicologia unipersonale e quello della sua analisi personale che può utilizzare solo in parte. Infatti lavorare in un contesto-setting multipersonale significa al-lenarsi a cogliere le interazioni tra i partecipanti e le manifestazioni dell'inconscio ectopi-co che emergono. Inoltre, nei processi formativi grande rilevanza assume l'esperienza gruppale degli allievi che dialoga con la gruppalità dei docenti. La dimensione gruppale è un'esperienza fondamentale che aiuta il terapeuta a confrontarsi continuamente con il qui e ora che si genera negli scambi orizzontali del gruppo e che lo mette in contatto con l'imprevisto e con la parzialità dell'esperienza che incontra nel lavoro con le coppie e le famiglie. Infine vengono ripensate e discusse le relazioni presentate da Grassi e Lucarelli che precedono la lettura del lavoro.

La competenza docimologica degli insegnanti costituisce uno dei perni dell'azione didattica allorché essa può costituire, di fatto, una molla per la promozione dell'apprendimento, dell'autonomia e del successo formativo di ogni alunno. Il feedback, inteso come strumento privilegiato nell'esercizio della prassi valutativa, offre l'opportunità di valorizzare la singolarità dei percorsi di ogni studente intelaiando interazioni comunicative volte alla co-costruzione di conoscenza. La competenza docimologica degli insegnanti assume, pertanto, i connotati della competenza comunicativa, la quale sostanzia e orienta le scelte valutative diversificando registri linguistici e scelte degli strumenti di comunicazione in ordine la tipologia di feedback funzionale al successo formativo. Lo studio si propone di illustrare i risultati di un processo di ricerca, messo in atto con 385 docenti di scuola secondaria della provincia di Caltanissetta nell'a.a. 2020/2021. Attraverso il processo di ricerca si è voluto incrementare negli insegnanti la competenza docimologica come competenza comunicativo-didattica centrata sul feedback.

Progettare pratiche didattiche partecipative in ambienti universitari, in sinergia con i servizi educativi locali, significa coltivare il dialogo tra professionalità presenti e future, creando un terreno di scambio e di arricchimento reciproco, dove teoria e prassi si nutrono vicendevolmente per co-costruire strategie inedite in risposta a sfide emergenti.All'interno di percorsi formativi online in chiave professionalizzante – messi in campo durante l'emergenza pandemica – i processi di produzione-ricezione di feedback tra gli attori in gioco hanno alimentato riflessioni pedagogiche e azioni progettuali, dando vita a una "palestra di incontri" in cui affinare competenze professionali e coltivare sguardi consapevoli sul profilo del professionista educativo, grazie anche alla testimonianza degli operatori sul campo. La sperimentazione di tali processi – ripercorsi in chiave riflessiva per rintracciarne gli snodi significativi – apre a ulteriori piste di progettazione didattica in prospettiva laboratoriale e chiama in causa l'Università come comunità viva, affinché mantenga il dialogo con gli studenti e le studentesse, accompagnandoli nell'esplorazione di identità personali e professionali.

Marine macroalgae are present in the ocean and more particularly in the coastal zone. Their distribution is related to biotic and abiotic factors. Considered as sustainable raw materials for a wide range of value-added products and energy production, they are valued in the fields of human and plant health, agriculture, food or construction (Baghel et al., 2020). Since 2011, large rafts of brown algae of the genus Sargassum have been observed, causing strandings in West Africa, throughout the Caribbean basin and the Gulf of Mexico. These include the species S. fluitans and S. natans. Faced with this recurring phenomenon of massive seaweed strandings, the French State has made a strong commitment to the fight against these phenomena: after a first crisis management plan in 2018, a second plan (2022-2025) was deployed with a view in particular to better prevention, health monitoring and the recovery of collected algae. In Guadeloupe, there are still around 116,000 m3 of sargassum stranded each year (ADEME in Guadeloupe, 2018). At present, valorization, which is very partial (90% of the algae collected is stored without use), is mainly done by composting or manufacturing biomaterials. This untapped biomass could be valorized in the energy sector by Anaerobic Digestion (AD) for the production of a gas rich in methane (anr.fr/Projet-ANR-19-SARG-0009 “Valorisation agro-énergétique des Sargasses – SAVE”). The objective of this study is to perform AD experiments with S. muticum as a substrate, a brown alga with characteristics similar to the previously mentioned stranded species, in order to assess their Bio-Methanogenic Potential (BMP), define the experimental conditions of AD, and to propose, in the long term, an energy recovery of the co-products resulting from the biorefining of seaweed stranded or harvested at sea.

The introduction of efficient and affordable catalysts for three seemingly simple electrochemical reactions could improve very much the sustainability of our energy supply: reduction of protons to hydrogen gas (the hydrogen evolution reaction, HER), water oxidation, and selective reduction of oxygen to water (the oxygen reduction reaction, ORR).1–6 Platinum group metals (PGM) are outstanding catalysts for all these reactions, but being rare and expensive prevents their utility for large scale operations.7 Within the search for catalysts based on earth abundant 1st row transition metals, we now introduce two different molecular catalysts: Co(III) complexes of corroles, with very different in size meso-C substituents (C6F5 >> CF3 >> H), as well by newly synthesized and fully characterized Co(II), Cu(II) and Ni(II) monoazaporphyrins (MAzP) with meso-CF3 substituents. All the catalyst were adsorbed on carbon supports with very different porosity (Vulcan << BP2000). The corrole-modified electrodes were studied as ORR catalysts, revealing that the onset potential of the best performing cobalt corrole is approaching that of Pt and with low percentage formation of undesired hydrogen peroxide. Testing that complex as a cathode for an anion exchange membrane fuel cell (AEMFC) revealed high power density relative to other molecular catalysts and excellent stability over 12 hours. Metal complexes of a novel MAzP with CF3 on the three meso-C positions were studied as catalysts for HER in PBS buffer (pH=7.4), as well as for water oxidation and ORR at pH 13. The cobalt complex performed best in all processes. Compared to cobalt porphyrins with either three or four CF3 groups on the meso-C positions, Co-MAzP performed better for water oxidation. For HER catalysis, it has the same onset potential and current as the tetra-CF3 cobalt porphyrin and more current than the tris-CF3 analogue. In ORR catalysis, Co-MAzP performs with the lowest onset potential, but less H2O2 is formed via catalysis by the other porphyrins. (1) Meng, J.; Lei, H.; Li, X.; Qi, J.; Zhang, W.; Cao, R. Attaching Cobalt Corroles onto Carbon Nanotubes: Verification of Four-Electron Oxygen Reduction by Mononuclear Cobalt Complexes with Significantly Improved Efficiency. ACS catalysis. 2019, pp 4551–4560. (2) Beyene, B. B.; Hung, C.-H. Recent Progress on Metalloporphyrin-Based Hydrogen Evolution Catalysis. Coord. Chem. Rev. 2020, 410, 213234. (3) Mondal, B.; Chattopadhyay, S.; Dey, S.; Mahammed, A.; Mittra, K.; Rana, A.; Gross, Z.; Dey, A. Elucidation of Factors That Govern the 2e–/2H+ vs 4e–/4H+ Selectivity of Water Oxidation by a Cobalt Corrole. J. Am. Chem. Soc. 2020, 142 (50), 21040–21049. (4) Cui, X.; Cui, Y.; Chen, M.; Xiong, R.; Huang, Y.; Liu, X. Enhancing Electrochemical Hydrogen Evolution Performance of CoMoO4-Based Microrod Arrays in Neutral Media through Alkaline Activation. ACS Appl. Mater. Interfaces 2020, 12 (27), 30905–30914. (5) Fornaciari, J. C.; Weng, L.-C.; Alia, S. M.; Zhan, C.; Pham, T. A.; Bell, A. T.; Ogitsu, T.; Danilovic, N.; Weber, A. Z. Mechanistic Understanding of PH Effects on the Oxygen Evolution Reaction. Electrochim. Acta 2022, 405, 139810. (6) Yao, B.; He, Y.; Wang, S.; Sun, H.; Liu, X. Recent Advances in Porphyrin-Based Systems for Electrochemical Oxygen Evolution Reaction. International journal of molecular sciences. 2022, p 6036. (7) Mehta, V.; Cooper, J. S. Review and Analysis of PEM Fuel Cell Design and Manufacturing. Journal of power sources. 2003, pp 32–53.

El artículo de Chantal Medici con que se inicia este número de la revista discute contribuciones críticas a la teoría convencional de la acción colectiva heredera de los trabajos seminales de Charles Tilly y del supuesto de la nitidez de una hipotética frontera entre lo público y lo privado, agrupándolas en tres tipos de abordaje: las que ponen énfasis en el activismo institucional del Estado, las que lo hacen en la construcción de redes o co[1]munidades de políticas y las que dan especial atención a la articulación público/privado en la construcción del problema y en su implementación. Las contribuciones revisadas entroncan con una variedad de enfoques desde la Ciencia Política, en particular la tesis de Lindblom sobre la relación entre estados y mercados en la formación de las políticas públicas, el planteo de Migdal sobre “el Estado en la sociedad” o, en nuestra América, la teoría de Carlos Matus sobre la complejidad del juego social. El texto de Sofya Surtayeva muestra el rol estratégico del Estado en la gestación y desarrollo de una política pública en un asunto de alta complejidad, en un país de la semiperiferia del capitalismo. Hace casi dos décadas nuestro compatriota Hugo Notcheff demostró la estrecha vinculación del carácter dependiente del capitalismo argentino y la consiguiente fragilidad de la política de ciencia y tecnología, con la orientación de la cúpula del poder económico hacia la valorización de su capital por la vía de la obtención de ganancias extraordinarias de la explotación de recursos naturales, la disponibilidad de trabajo barato y la obtención de subsidios y otras preferencias estatales, mucho más que del estímulo a la innovación científico tecnológica y a una política encaminada a su desarrollo. El corolario es una modernización de la economía basada en la importación de innovaciones provenientes de las economías centrales, favorecida por la estrecha integración con capitales extranjeros, con efecto en la fragilidad de las políticas de desarrollo científico y tecnológico y la preservación de la dependencia. Tomando como hilo conductor el papel de la Comisión Nacional de Energía Atómica en el desarrollo de la nanotecnología la autora muestra las particularidades de un proceso de innovación en una doble faceta: el impulso a un área de conocimiento y la promoción por la CNEA de un enfoque propio más afín a una estrategia de desarrollo sostenible y mayor autonomía nacional. El artículo brinda asimismo una detallada aproximación a la pluralidad de actores e intereses, la relevancia del liderazgo en la definición de la política y la gravitación de todo ello en el desarrollo científico-tecnológico y la inserción en el tema y la gravitación de las diferentes respuestas posibles en la inserción de Argentina en el sistema global. En esta línea de elaboración, Mariano Gil describe las políticas públicas ejecutadas en la provincia de Santa Fe para el abordaje del consumo problemático de sustancias. Su trabajo destaca los varios actores públicos, privados y comunitarios que intervienen con desigual eficacia en la construcción del problema, la incidencia de esa construcción en las acciones y organismos que habrán de encararlo, las modificaciones que la política adoptada experimenta a medida que va siendo implementada y esa misma implementación introduce cambios en los escenarios, en los sujetos a quienes se dirige, en los aparatos del estado y en los agentes que tienen a cargo la implementación. Burócratas, decisores políticos, organizaciones no gubernamentales, familias, organismos de seguridad pública, profesionales y técnicos de la salud integran un arco amplio de sujetos que intervienen en la gestión de la política. Por su parte Miguel Alfredo y Pablo Granovsky se ocupan de dos experiencias de centros de formación profesional en el marco del entramado de actores que intervienen en la intersección entre políticas de educación, políticas laborales y organizaciones categoriales: los casos de gestión de políticas de formación profesional de la UOCRA (Unión Obrera de la Construcción de la República Argentina) y del SMATA (Sindicato de Mecánicos y Afines del Transporte Automotor). El artículo de Pablo Schamber y Francisco Suárez ofrece un detallado análisis de una experiencia de articulación estado/actores sociales en la ejecución de una política ambiental urbana, a través de la inclusión de los recolectores informales de residuos reciclables en la política estatal de gestión de los residuos. Una experiencia que, a juicio de los autores, supera cualquier otra existente en el mundo. Más allá de la especificidad de sus temas de estudio, los tres artículos destacan la pluralidad de actores que participan desde uno y otro “lado” de la diferenciación público-privada en cada uno de esos temas, en el empeño de configurar una política que es siempre herramienta de una construcción de poder que, en la medida en que institucionaliza alguna forma de transacción entre quienes participan, se proyecta hacia ámbitos más amplios que los específicos. El fomento de la educación pública es presentado normalmente como una vía para la reducción de los niveles de desigualdad social: una típica “ventana de oportunidades”. Judith Pinos Montenegro discute este asunto en su trabajo sobre la promoción de la educación básica en Ecuador durante los gobiernos de la Revolución Ciudadana. Destaca la polisemia del vocablo igualdad como aparece en los documentos oficiales, incrementada por la naturaleza pluriétnica de la sociedad ecuatoriana y las contradicciones culturales y de clase que se registran entre la educación pública y la privada. José Candelario Osuna García encara el tema desde la perspectiva del desplazamiento temporal de miles de familias mexicanas de bajos ingresos por razones laborales, que lleva a la interrupción de la trayectoria escolar de los niños, niñas y jóvenes involucrados en esas migraciones y relativiza a su respecto el principio de igualdad en el acceso al derecho a la educación. El artículo enfoca el Programa de Educación para Poblaciones Migrantes elaborado por el gobierno del estado de Baja California, con el fin de minimizar los riesgos en materia de formación escolar y cultural derivados de la inserción de las familias en la estructura transfronteriza del mercado de trabajo y el sistema productivo. Fácilmente se advierte entonces que el modo de inserción en la matriz social condiciona el acceso efectivo a derechos. Los campesinos pobres, los trabajadores migrantes, las poblaciones originarias a quienes se refieren los textos precedentes ven reducidas sus oportunidades de educación por la posición que ocupan en esa matriz social; en ausencia de intervención estatal las desigualdades se potencian porque el sistema educativo no cumple respecto de esos sujetos la función promocional que debería contribuir a un cambio en su posición en la estructura. El régimen político, con su propia concepción de la igualdad, refuerza y expande o acota y neutraliza el sistema dominante de desigualdades. Hace veinticinco siglos Aristóteles destacó que las ideas predominantes en materia de igualdad y desigualdad y sus causas va[1]rían de acuerdo al régimen político, es decir a la organización y distribución del poder. Cambiando el régimen político, cambian antes o después las ideas de igualdad, y por tanto de justicia promovidas desde el Estado y las políticas públicas. La asunción en Uruguay en marzo 2020 de un gobierno de corte neoliberal implicó cambios importantes en las políticas sociales en general y asistenciales en particular, de fuerte contraste con las que caracterizaron a los quince años precedentes de gobierno del Frente Amplio. Ximena Baráibar Ribero analiza la conceptualización de la política del nuevo gobierno de asistencia a poblaciones en situación de pobreza: un conjunto de acciones de estímulo a la superación individual y la responsabilidad personal de los afectados, y un papel residual del Estado. Pobreza y desigualdad son, en el diseño intelectual de las nuevas autoridades, fenómenos individuales tanto en sus causas como en sus efectos. Las políticas sociales no tendrían otro fin que facilitar un tránsito a oportunidades individuales que se asumen discursivamente, no se discuten como realidad y dejan de lado la pregunta sobre los factores sociales, es decir colectivos, que crean condiciones para la gestación y desarrollo de las situaciones individuales. Carlos M. Vilas Director

Increasing incidence of chronic diseases (bronchial asthma, allergic conditions, cancer, multiple sclerosis), unmet clinical needs for the treatment of immune disorders such as rheumatoid arthritis, increasing number of post-covid diseases are driving the growth of the immunomodulator market. The global CAGR of the immunomodulator market is expected to be 5.4% during 2022–2027. That is why immunomodulators (immunostimulators and immunosuppressants) are a promising segment of the pharmaceutical market. The aim of the work was to study the range of immunomodulators (in terms of immunostimulators and immunosuppressants) on the pharmaceutical market of Ukraine in wartime conditions and their price conjuncture and economic availability using the example of immunostimulators. The algorithm of our research included 3 stages. The first provided an analysis of the current nomenclature of immunostimulators registered in Ukraine as of February 1, 2023. The second – a study of the price conjuncture of the retail segment of the market and the economic availability of immunostimulators. The third - a study of the marketing characteristics of immunosuppressants. At the first stage of the research, the results of which are presented in this article, the methods of information search, content analysis, data systematization and generalization have been used. The object of study was the data of the information fund «State Register of Drugs of Ukraine» regarding immunostimulators available on the domestic pharmaceutical market. It has been established that as of February 1, 2023, 12 INN immunostimulators in the form of 114 drugs were registered in Ukraine. At the same time, the most numerous group of the assortment is interferon alfa-2b drugs (35.96%), and by type of ALP – injectable ALP (52.63%). It has been found that almost two-thirds (61.41%) of registered drugs from the group of immunostimulators are represented by Ukraine, the rest (38.59%) – by 24 foreign producing countries. At the same time, it was shown for the first time that 9 or 12.86% of Ukrainian-made pharmaceuticals and 24 or 54.55% of foreign-made pharmaceuticals are the result of production cooperation of several enterprises. Among Ukrainian manufacturers, the largest number of drugs (27.14% of the range of individual production and 7.14% of the range in cooperation with other enterprises) was registered by Scientific Production Company «Interpharmbiotek» LLC. Among foreign countries, the largest number of immunostimulators on the Ukrainian market is represented by Germany – 12 German manufacturing companies are involved in the production of 16 of them. Three foreign manufacturers (Accord Helskea Limited, Great Britain, Teva Pharmaceutical Industries Ltd., Israel and Sanum-Kelbeck GmbH & Co. KG, Germany) produce 4 drugs each, and other foreign enterprises are involved in the production of one to three drugs. The results of the study can be used in the formation of the assortment policy of pharmaceutical companies, wholesalers and pharmacies.

Abstract Post-translational glycosylation determines the pharmacodynamic and pharmacokinetic properties of therapeutic proteins. While desialylation of FVIII/VWF (asialo-FVIII/VWF) has a significantly reduced half-life compared to normal FVIII/VWF complex (Sodetz et al 1977), we introduced additional sialic acids on recombinant (r) FVIII to obtain the opposite: prolonged survival of rFVIII in the circulation. Additional sialic acid residues were introduced to rFVIII by covalently binding polysialic acid (PSA) to full length (FL) rFVIII. The resulting drug candidate BAX 826, polysialylated human rFVIII, is manufactured from octocog alfa which is expressed in Chinese Hamster Ovary Cells by a plasma/albumin free cell culture method and is the active substance in Baxalta´s licensed product ADVATE. The manufacturing process for BAX 826 comprises several steps, starting with the bulk drug substance (BDS) of the ADVATE process which is subjected to polysialylation, i.e. covalent attachment of PSA of an average molecular weight of 20 kDa to rFVIII. Polysialylation is followed by a sequence of chromatographic purification steps and concentration of the conjugate by an ultra-/diafiltration step leading to the pre-formulated BDS. Final formulation of the BDS includes a filling and lyophilization step to obtain the final drug product. The process described is suited to manufacture BAX 826 in large scale and showed a good batch to batch consistency, ensuring an equivalent product quality for each batch. BAX 826 was extensively structurally and functionally characterized. The methods used included reducing and non-reducing peptide mapping to determine amino acid sequence and post translational modifications, qualitative analysis of modification sites, SDS-PAGE and Western blot analysis, assessment of three dimensional structure similarities of BAX 826 and rFVIII, ADVATE, by Fourier-transformed infrared spectroscopy (FTIR), dynamic light scattering (DLS) and circular dichroism (CD). Functional characterization was performed by assessment of the kinetics of the assembly and activity of FIXa-FVIII (tenase) complex, determination of the rate of activation and inactivation of BAX 826 by thrombin, determination of overall hemostatic potency by a thrombin generation assay, measurement of the rate of inactivation of untreated or thrombin-activated BAX 826 by activated protein C, measurement of kinetics of the binding of BAX 826 to von Willebrand factor (VWF), to phospholipids, and to low-density lipoprotein (LDL)-receptor-related protein 1 (LRP1) by surface plasmon resonance spectroscopy. While BAX 826 retained full hemostatic functionality of FVIII as a co-factor of the tenase complex, and can thus be considered a fully active FVIII molecule, it was found to have a reduced binding to VWF and to LRP1. Together with the conception that VWF as FVIII's chaperone dictates the maximally achievable terminal half-life extension for FVIII reduced binding to VWF and FVIII's major clearance receptor LRP1likely explains the prolonged pharmacokinetic (PK) properties when comparing BAX 826 with unmodified FL rFVIII in animal models. In summary, BAX 826, a polysialylated rFVIII derivative, can be manufactured reproducibly without relevant changes to the protein structure characteristic for a functional FVIII molecule with high specific activity. Disclosures Turecek: Baxalta Innovations GmbH: Employment. Siekmann:Baxalta Innovations GmbH: Employment. Mitterer:Baxalta Innovations GmH: Employment. Graninger:Baxalta Innovations GmbH: Employment. Schrenk:Baxalta Innovations GmbH: Employment. Matthiessen:Baxalta Innovations GmbH: Employment. Rottensteiner:Baxalta Innovations GmbH: Employment. Hoellriegl:Baxalta Innovations GmbH: Employment. Putz:Baxalta Innovations GmbH: Employment. Schwarz:Baxalta Innovations GmbH: Employment. Scheiflinger:Baxalta Innovations GmbH: Employment.

Among actions undertaken to reach a net-zero economy by 2050, implementation of the hydrogen technologies into various sectors e.g. energy and transport seems to be crucial. The significant increase of the installed capacity of electrolyzer in the last few years has been observed, which will accelerate in next decades to meet declared by many countries goals of their national hydrogen strategies. Nowadays, a dominant role on the electrolyze markets possess low temperature solution, namely, alkaline and PEM electrolyzes. However, due to higher efficiency – lower energy demand for hydrogen production, it is forecast that solid oxide electrolyzers (SOE) will take part of the market. The development of SOE, which are on the final R&D phase, is mainly focused on the extension of their lifespan and minimizing their manufacturing costs. The La1-xSrxCoO3-δ (LSC) and La1-xSrxCoyFe1-yO3-δ (LSCF) oxides due to their good catalytic activity and high mixed ionic-electronic conductivity are recognized as state-of-the-art air electrodes for SOC. However, Co-based perovskites are characterized by high thermal and chemical expansion, which might cause a mechanical mismatch with electrolyte, resulting in intensified SOC degradation. To mitigate mentioned issues different strategies have been proposed in the literature. Through the combined approach focused on modification of the bulk properties, simultaneously tailoring the microstructure of the electrodes and electrode/solid electrolyte interface, it is possible to overcome the kinetic limitations of operation at decreased temperatures. To maximize cell performance, and prevent the potential electrode degradation (i.e. its delamination) composite GDC-LSC/LSFC electrodes with gradual changes of the composition from electrolyte-electrode interphase to the electrode surface, were proposed. Furthermore, the impact of modification of electrode microstructure by an increase of its porosity and infiltration of the electrode surface with catalytically active oxides (e.g. PrxOy) was investigated. Fine-tuning of electrode porosity was achieved by the addition of the pore-forming agent, and the selection of its type (graphite or PMMA), amount, and size of its grains. Moreover, the work presents an approach to optimize the buffer layer, inter alia by its densifying, to mitigate Sr diffusion to the electrolyte and prevent air electrode delamination. The developed composite air electrodes were screen-printed (with an active area of 16 cm2) on the fuel electrode-supported cell and evaluated in the SOE mode at the 650-750 °C temperature range. Tests included measurements of j-V dependences and EIS spectra (at different temperatures, current densities, and for different gas flow delivered at the air side of the cell). In order to assess the impact of the added amount and type of pore-forming agent on the microstructure of the electrode layer, as well as to investigate possible microstructural changes of the cell after testing SEM, SEM-EDS, and FIB-SEM analysis were performed. The proposed modification of the composition and microstructure resulted in higher current densities and reduced cell polarization compared to standard cells with LSC and LSCF as the air electrode. Acknowledgments The presented research was financially supported by: the National Centre for Research and Development, Poland, within project no. LIDER/1/0003/L-12/20/NCBR/2021 (research related to composite GDC-LSC/LSFC electrodes), and Ministry of Science and Higher Education through the statutory grant, within grant no. CPE.4000.001.2023 (research related to the improvement of the buffer layer-electrode interphase).

AbstractThe biomass valorisation of the invasive brown alga Rugulopteryx okamurae (Dictyotales, Phaeophyceae) is key to curbing the expansion of this invasive macroalga which is generating tonnes of biomass on southern Spain beaches. As a feasible alternative for the biomass management, anaerobic co-digestion is proposed in this study. Although the anaerobic digestion of macroalgae barely produced 177 mL of CH4 g−1 VS, the co-digestion with a C-rich substrate, such as the olive mill solid waste (OMSW, the main waste derived from the two-phase olive oil manufacturing process), improved the anaerobic digestion process. The mixture improved not only the methane yield, but also its biodegradability. The highest biodegradability was found in the mixture 1 R. okamurae—1 OMSW, which improved the biodegradability of the macroalgae by 12.9% and 38.1% for the OMSW. The highest methane yield was observed for the mixture 1 R. okamurae—3 OMSW, improving the methane production of macroalgae alone by 157% and the OMSW methane production by 8.6%. Two mathematical models were used to fit the experimental data of methane production time with the aim of assessing the processes and obtaining the kinetic constants of the anaerobic co-digestion of different combination of R. okamurae and OMSW and both substrates independently. First-order kinetic and the transference function models allowed for appropriately fitting the experimental results of methane production with digestion time. The specific rate constant, k (first-order model) for the mixture 1 R. okamurae- 1.5 OMSW, was 5.1 and 1.3 times higher than that obtained for the mono-digestion of single OMSW and the macroalga, respectively. In the same way, the transference function model revealed that the maximum methane production rate (Rmax) was also found for the mixture 1 R. okamurae—1.5 OMSW (30.4 mL CH4 g−1 VS day−1), which was 1.6 and 2.2 times higher than the corresponding to the mono-digestions of the single OMSW and sole R. okamurae (18.9 and 13.6 mL CH4 g−1 VS day−1), respectively.

Background: Cancer is the leading cause of death worldwide accounting for about 22% of mortality as per WHO. In spite of ever-increasing efforts to understand it as a process, its incidence in the population increasing day by day. A unique perspective of diagnosis and treatment can be seen in ayurveda with the inculcation of natural remedies, rasoushadhi prayoga, rasayana prayoga and preventive strategies. Materials and methods: Some of the common rasa(mineral) preparations given internally are navajeevana rasa, kamadugdha rasa, keharuba pisthi, navapasanam, raktamritha somakalpa sinduram, pravala chandrodaya rasa, chandramritha sinduram, kapala bhasma apart from single rasa dravya prayoga. Results: Rasaoushadhies are recommended in minute doses/trace or ultra-trace amounts (Alpa/Swalpa Matra) and since these are inorganic in nature most often, they are tasteless hence not poses any problem of palatability or acceptability. Ayurvedic preparations can act as an adjuvant or a co-therapy along with chemotherapy or radiotherapy. It is also helpful in post surgery care. Conclusion: Cancer treatment through ayurveda does not only focus on the area of the malignancy but on the entire system, as the whole-body crust return to harmony for the disease to be traced permanently and not reoccur elsewhere. This can be effectively done by rasoushadhi chikitsa (herbo mineral treatment)

Every crisis at the same time reveals, forewarns and implies changes with cyclical trends that can be analyzed from different disciplinary perspectives, building scenarios to anticipate the future, despite uncertainties and risks. And the current crisis certainly appears as one of the most problematic of the modern era: recently, Luigi Ferrara, Director of the School of Design at the George Brown College in Toronto and of the connected Institute without Boundaries, highlighted how the pandemic has simply accelerated undergoing dynamics, exacerbating other crises – climatic, environmental, social, economic – which had already been going on for a long time both locally and globally. In the most economically developed contexts, from North America to Europe, the Covid emergency has led, for example, to the closure of almost 30% of the retail trade, as well as to the disposal and sale of many churches. Places of care and assistance, such as hospitals and elderly houses, have become places of death and isolation for over a year, or have been closed. At the same time, the pandemic has imposed the revolution of the remote working and education, which was heralded – without much success – more than twenty years ago. In these even contradictory dynamics, Ferrara sees many possibilities: new roles for stronger and more capable public institutions as well as the opportunity to rethink and redesign the built environment and the landscape. Last but not least, against a future that could be configured as dystopian, a unique chance to enable forms of citizenship and communities capable of inhabiting more sustainable, intelligent and ethical cities and territories; and architects capable of designing them. This multifactorial and pervasive crisis seems therefore to impose a deep review of the current unequal development models, in the perspective of that “creative destruction” that Schumpeter placed at the basis of the dynamic entrepreneurial push: «To produce means to combine materials and forces within our reach. To produce other things, or the same things by a different method, means to combine these materials and forces differently» (Schumpeter, 1912). A concept well suiting to the design practice as a response to social needs and improving the living conditions. This is the perspective of Architectural Technology, in its various forms, which has always placed the experimental method at the center of its action. As Eduardo Vittoria already pointed out: «The specific contribution of the technological project to the development of an industrial culture is aimed at balancing the emotional-aesthetic data of the design with the technical-productive data of the industry. Design becomes a place of convergence of ideas and skills related to factuality, based on a multidisciplinary intelligence» (Vittoria, 1999). A lucid and appropriate critique of the many formalistic emphases that have invested contemporary architecture. In the most acute phases of the pandemic, the radical nature of this polycrisis has been repeatedly invoked as a lever for an equally radical modification of the development models, for the definitive defeat of conjunctural and emergency modes of action. With particular reference to the Italian context, however, it seems improper to talk about a “change of models” – whether economic, social, productive or programming, rather than technological innovation – since in the national reality the models and reference systems prove to not to be actually structured. The current socio-economic and productive framework, and the political and planning actions themselves, are rather a variegated and disordered set of consolidated practices, habits often distorted when not deleterious, that correspond to stratified regulatory apparatuses, which are inconsistent and often ineffective. It is even more difficult to talk about programmatic rationality models in the specific sector of construction and built environment transformation, where the enunciation of objectives and the prospection of planning actions rarely achieve adequate projects and certain implementation processes, verified for the consistency of the results obtained and monitored for the ability in maintaining the required performance over time. Rather than “changing the model”, in the Italian case, we should therefore talk about giving shape and implementation to an organic and rational system of multilevel and inter-sectorial governance models, which assumes the principles of subsidiarity, administrative decentralization, inter-institutional and public-private cooperation. But, even in the current situation, with the pandemic not yet over, we are already experiencing a sort of “return to order”: after having envisaged radical changes – new urban models environmentally and climatically more sustainable, residential systems and public spaces more responsive to the pressing needs of social demand, priority actions to redevelop the suburbs and to strength infrastructures and ecosystem services, new advanced forms of decision-making decentralization for the co-planning of urban and territorial transformations, and so on – everything seems to has been reset to zero. This is evident from the list of actions and projects proposed by the National Recovery and Resilience Plan (NRRP), where no clear national strategy for green transition emerges, even though it is repeatedly mentioned. As highlighted by the Coordination of Technical-Scientific Associations for the Environment and Landscape1, and as required by EU guidelines2, this transition requires a paradigm shift that assumes eco-sustainability as a transversal guideline for all actions. With the primary objective of protecting ecosystem balances, improving and enhancing the natural and landscape capital, as well as protecting citizen health and well-being from environmental risks and from those generated by improper anthropization phenomena. The contents of the Plan explicitly emphases the need to «repair the economic and social damage of the pandemic crisis» and to «contribute to addressing the structural weaknesses of the Italian economy», two certainly relevant objectives, the pursuit of which, however, could paradoxically contrast precisely with the transition to a more sustainable development. In the Plan, the green revolution and the ecological transition are resolved in a dedicated axis (waste management, hydrogen, energy efficiency of buildings, without however specific reform guidelines of the broader “energy” sector), while «only one of the projects of the Plan regards directly the theme Biodiversity / Ecosystem / Landscape, and in a completely marginal way» (CATAP, 2021). Actions are also limited for assessing the environmental sustainability of the interventions, except the provision of an ad hoc Commission for the streamlining of some procedural steps and a generic indication of compliance with the DNSH-Do not significant Harm criterion (do not cause any significant damage), without specific guidelines on the evaluation methods. Moreover, little or nothing in the Plan refers on actions and investments in urban renewal, abandoned heritage recovery3, of in protecting and enhancing areas characterized by environmental sensitivity/fragility; situations widely present on the national territory, which are instead the first resource for a structural environmental transition. Finally yet importantly, the well-known inability to manage expenditure and the public administration inefficiencies must be considered: a limit not only to the effective implementation of projects, but also to the control of the relationship between time, costs and quality (also environmental) of the interventions. In many places, the Plan has been talked about as an opportunity for a real “reconstruction”, similar to that of post-war Italy; forgetting that the socio-economic renaissance was driven by the INA-Casa Plan4, but also by a considerable robustness of the cultural approach in the research and experimentation of new housing models (Schiaffonati, 2014)5. A possible “model”, which – appropriately updated in socio-technical and environmental terms – could be a reference for an incisive governmental action aiming at answering to a question – the one of the housing – far from being resolved and still a priority, if not an emergency. The crisis also implies the deployment of new skills, with a review of outdated disciplinary approaches, abandoning all corporate resistances and subcultures that have long prevented the change. A particularly deep fracture in our country, which has implications in research, education and professions, dramatically evident in the disciplines of architectural and urban design. Coherently with the EU Strategic Agenda 2019-2024 and the European Pillar of Social Rights, the action plan presented by the Commission in March 2021, with the commitment of the Declaration of Porto on May 7, sets three main objectives for 2030: an employment rate higher than 78%, the participation of more than 60% of adults in training courses every year and at least 15 million fewer people at risk of social exclusion or poverty6. Education, training and retraining, lifelong learning and employment-oriented skills, placed at the center of EU policy action, now require large investments, to stimulate employment transitions towards the emerging sectors of green, circular and digital economies (environmental design and assessment, risk assessment & management, safety, durability and maintainability, design and management of the life cycle of plans, projects, building systems and components: contents that are completely marginal or absent in the current training offer of Architecture). Departments and PhDs in the Technological Area have actively worked with considerable effectiveness in this field. In these regards, we have to recall the role played by Romano Del Nord «protagonist for commitment and clarity in identifying fundamental strategic lines for the cultural and professional training of architects, in the face of unprecedented changes of the environmental and production context» (Schiaffonati, 2021). Today, on the other hand, the axis of permanent and technical training is almost forgotten by ministerial and university policies for the reorganization of teaching systems, with a lack of strategic visions for bridging the deficit of skills that characterizes the area of architecture on the facing environmental and socio-economic challenges. Also and precisely in the dual perspective of greater interaction with the research systems and with the world of companies and institutions, and of that trans- and multi-disciplinary dimension of knowledge, methods and techniques necessary for the ecological transition of settlement systems and construction sector. Due to the high awareness of the Technological Area about the multifactorial and multi-scale dimension of the crises that recurrently affect our territories, SITdA has been configured since its foundation as a place for scientific and cultural debate on the research and training themes. With a critical approach to the consoling academic attitude looking for a “specific disciplinary” external and extraneous to the social production of goods and services. Finalizing the action of our community to «activate relationships between universities, professions, institutions through the promotion of the technological culture of architecture [...], to offer scientific-cultural resources for the training and qualification of young researchers [...], in collaboration with the national education system in order to advance training in the areas of technology and innovation in architecture» (SITdA Statute, 2007). Goals and topics which seem to be current, which Techne intends to resume and develop in the next issues, and already widely present in this n. 22 dedicated to the Circular Economy. A theme that, as emerges from the contributions, permeates the entire field of action of the project: housing, services, public space, suburbs, infrastructures, production, buildings. All contexts in which technological innovation invests both processes and products: artificial intelligence, robotics and automation, internet of things, 3D printing, sensors, nano and biotechnology, biomaterials, biogenetics and neuroscience feed advanced experiments that cross-fertilize different contributions towards common objectives of circularity and sustainability. In this context, the issue of waste, the superfluous, abandonment and waste, emerge, raising the question of re-purpose: an action that crosses a large panel of cases, due to the presence of a vast heritage of resources – materials, artefacts, spaces and entire territories – to be recovered and re-functionalized, transforming, adapting, reusing, reconverting, reactivating the existing for new purposes and uses, or adapting it to new and changing needs. Therefore, by adopting strategies and techniques of reconversion and reuse, of re-manufacturing and recycling of construction and demolition waste, of design for disassembly that operate along even unprecedented supply chains and which are accompanied by actions to extend the useful life cycle of materials , components and building systems, as well as product service logic also extended to durable goods such as the housing. These are complex perspectives but considerably interesting, feasible through the activation of adequate and updated skills systems, for a necessary and possible future, precisely starting from the ability – as designers, researchers and teachers in the area of Architectural Technology – to read the space and conceive a project within a system of rationalities, albeit limited, but substantially founded, which qualify the interventions through approaches validated in research and experimental verification. Contrarily to any ineffective academicism, which corresponds in fact to a condition of subordination caused by the hegemonic dynamics at the base of the crisis itself, but also by a loss of authority that derives from the inadequate preparation of the architects. An expropriation that legitimizes the worst ignorance in the government of the territories, cities and artifacts. Education in Architecture, strictly connected to the research from which contents and methods derive, has its central pivot in the project didactic: activity by its nature of a practical and experimental type, applied to specific places and contexts, concrete and material, and characterized by considerable complexity, due to the multiplicity of factors involved. This is what differentiates the construction sector, delegated to territorial and urban transformations, from any other sector. A sector that borrows its knowledge from other production processes, importing technologies and materials. With a complex integration of which the project is charged, for the realization of the buildings, along a succession of phases for corresponding to multiple regulatory and procedural constraints. The knowledge and rationalization of these processes are the basis of the evolution of the design and construction production approaches, as well as merely intuitive logics. These aspects were the subject of in-depth study at the SITdA National Conference on “Producing Project” (Reggio Calabria, 2018), and relaunched in a new perspective by the International Conference “The project in the digital age. Technology, Nature, Culture” scheduled in Naples on the 1st-2nd of July 2021. A reflection that Techne intends to further develop through the sharing of knowledge and scientific debate, selecting topics of great importance, to give voice to a new phase and recalling the practice of design research, in connection with the production context, institutions and social demand. “Inside the Polycrisis. The possible necessary” is the theme of the call we launched for n. 23, to plan the future despite the uncertainties and risks, foreshadowing strategies that support a unavoidable change, also by operating within the dynamics that, for better or for worse, will be triggered by the significant resources committed to the implementation of the Recovery Plan. To envisage systematic actions based on the centrality of a rational programming, of environmentally appropriate design at the architectural, urban and territorial scales, and of a continuous monitoring of the implementation processes. With the commitment also to promote, after each release, a public moment of reflection and critical assessment on the research progresses. NOTES 1 “Osservazioni del Coordinamento delle Associazioni Tecnico-scientifiche per l’Ambiente e il Paesaggio al PNRR”, 2021. 2 EU Guidelines, SWD-2021-12 final, 21.1.2021. 3 For instance, we can consider the 7,000 km of dismissed railways, with related buildings and areas. 4 The two seven-year activities of the Plan (1949-1963) promoted by Amintore Fanfani, Minister of Labor and Social Security at the time, represented both an employment and a social maneuver, which left us the important legacy of neighborhoods that still today they have their own precise identity, testimony of the architectural culture of the Italian twentieth century. But also a «grandiose machine for the housing» (Samonà, 1949), based on a clear institutional and organizational reorganization, with the establishment of a single body (articulated in the plan implementation committee, led by Filiberto Guala, with regulatory functions of disbursement of funds, assignment of tasks and supervision, and in the INA-Casa Management directed by the architect Arnaldo Foschini, then dean of the Faculty of Architecture), which led to the construction of two million rooms for over 350,000 families. See Di Biagi F. (2013), Il Contributo italiano alla storia del Pensiero – Tecnica, Enciclopedia Treccani. 5 From Quaderni of the Centro Studi INA-Casa, to Gescal and in the Eighties to the activity of CER. Complex theme investigated by Fabrizio Schiaffonati in Il progetto della residenza sociale, edited by Raffaella Riva. 6 Ferruccio De Bortoli underlines in Corriere della Sera of 15 May 2021: «The revolution of lifelong learning (which) is no less important for Brussels than the digital or green one. By 2030, at least 60 per cent of the active population will have to participate in training courses every year. It will be said: but 2030 is far away. There’s time. No, because most people have escaped that to achieve this goal, by 2025 – that is, in less than four years – 120 million Europeans will ideally return to school. A kind of great educational vaccination campaign. Day after tomorrow».