Dissertations / Theses on the topic 'ALS'
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Tornow, Sarah. "Art. 1 Abs. 1 GG als Grundrecht." Frankfurt, M. Berlin Bern Bruxelles New York, NY Oxford Wien Lang, 2007. http://d-nb.info/987899376/04.
Full textSchneider, Ulrich Johannes. "Ordnung als Schema und als Operation." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-149236.
Full textHelmersson, Katarina, and Ingrid Järpfält-Svensson. "ALS : Upplevelser av att leva med ALS." Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-19346.
Full textProgram: Fristående kurs
Stierle, Karlheinz. "Der Text als Werk und als Vollzug." Bärenreiter Verlag, 1998. https://slub.qucosa.de/id/qucosa%3A36793.
Full textLindvall, Jonas, and Heidi Hedberg. "Erfarenheter av att drabbas av och att leva med ALS : En kvalitativ litteraturstudie." Thesis, Linnéuniversitetet, Institutionen för hälso- och vårdvetenskap (HV), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-24120.
Full textBednjanec, Martina. "Calibration of ALS Intensity Data." Thesis, KTH, Geoinformatik och Geodesi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-38998.
Full textSaupe, Achim. "Der Historiker als Detektiv - der Detektiv als Historiker Historik, Kriminalistik und der Nationalsozialismus als Kriminalroman." Bielefeld Transcript, 2007. http://d-nb.info/99163215X/04.
Full textPollnick, Yvonne. "Der Terminator als Messias amerikanisches Actionkino als moderner Kulturträger." Taunusstein Driesen, 1993. http://d-nb.info/995736685/04.
Full textSchmid, Christian [Verfasser]. "Die Lebensversicherung als Kapitalsicherung und als Kapitalanlage / Christian Schmid." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1207882135/34.
Full textKindåker, Christoffer, and Madeleine Norberg. "Att leva med ALS : En litteraturstudie." Thesis, Ersta Sköndal högskola, Institutionen för vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-1401.
Full textBackground: Previous literature about ALS (amyotrophic lateral sclerosis) has mainly been performed from a medical point of view – the focus being on finding suitable methods for treating the disease. Several studies have also been performed to assess the quality of life among people with ALS. However there are fewer studies that describe how everyday life with the disease is experienced from a patient perspective. To provide sufficient support and assistance to people with ALS, various health care professions, including nurses, need to broaden their knowledge about the experiences from those who are the real experts, namely those who live their everyday lives with ALS. Aim: The study aims to describe the experience of living with ALS from a patient perspective. Method: To compile and deepen previous knowledge of what it is like to live with ALS, a systematic literature review of scientific articles has been done, that includes previous research in this area. Results: The result of this study consists of three themes that were developed during the data analysis. The most prominent theme included the sadness of getting a deadly disease and to realize that life would not last forever. Also the sadness of not knowing what would happen to loved ones after one’s own death was clearly a great concern to the participants as well. Despite the sadness over the disease, results show that participants in the various studies could still find happiness in life. The joy of having their families close and by living in the present they managed to keep up the struggle and still enjoy life. The disease generated a lot of questions about death and about value of life for those who participated in the studies. Some of the participants said that they regarded death as a relief from the pain and suffering brought about by ALS. Fear and uncertainty of what would happen after death was for some persons handled by creating hope for a better life elsewhere. The results also revealed that some of the participants accepted death as being a natural part of life. Discussion: Nurses attitudes towards patients with ALS are discussed, taken from the patient’s point of view. In accordance with a caring science perspective that appreciates the view of the patient as unique, there are as many ways to experience illness as there are people in the world. In order to gain knowledge about the patient’s life atmosphere, in this case everyday life with ALS, nurses need to be open and attentively listen to the patients’ experiences and feelings brought about by illness.
Leroy, Félix. "Atteinte différentielle de deux populations de motoneurones spinaux chez le souriceau SOD1 G93A (modèle de la maladie de Charcot)." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T063/document.
Full textIn the second postnatal week, the locomotor behavior of mice changes from crawling to walking. This is made possible by profound changes in motor units. Yet, how the discharge properties of spinal motoneurons evolve during post-‐natal maturation and whether they have an effect on the motor unit maturation remains an open question. In neonates, the spinal motoneurons display two modes of discharge. For threshold pulses, 33% of the motoneurons have a discharge that start at the current onset and adapts during the pulse (“immediate firing motoneurons”). The remaining 66% motoneurons fire with a large delay and the discharge then accelerates throughout the pulse (“delayed firing motoneurons”). Though the delayed firing pattern is quite common in spinal motoneurons of neonates, the ionic mechanisms that elicit this mode of discharge have received little attention. Using the patch-clamp technique to record P6‐P10 mouse motoneurons in a spinal cord slice preparation, I characterized the ionic currents that underlie the delayed firing pattern. This is caused by a combination of an A-like potassium current that acts on a short time scale and a slow‐inactivating potassium current that delays the discharge on a much longer time scale. I then investigated how these two potassium currents contribute to the recruitment threshold and how they shape the F-I function of delayed motoneurons in neonatal mice. The slow inactivating potassium current induces memory effects that have a strong impact on motoneuron excitability and on its discharge. Building on these results, I tried to correlate the discharge pattern to known physiological sub‐types. The delayed firing motoneurons have a larger input conductance, a higher rheobase, a narrower action potential, a shorter AHP and a more complex dendritic arbor than the immediate firing motoneurons. Additionally, only a sub-‐population of the delayed firing motoneurons expressed the chondrolectin protein, a fast motoneuron marker. Based on this body of corroborating evidence, the immediate firing motoneurons would be slow type motoneurons whereas the delayed firing motoneurons would be fast type motoneurons. Finally, numerous electrical and geometrical abnormalities have been observed in spinal motoneurons of SOD1 G934 mice (model of the amyotrophic lateral sclerosis) during the second post-natal week but the results were somehow contradictory. In relation to the known differential sensitivity to the disease exhibited by slow and fast motoneurons, I investigated whether the immediate and delayed firing motoneurons are equally affected by the SOD1 mutation. This is not the case. I found that the SOD1 mutation induced a decrease in the rheobase and a hyperpolarization of the voltage threshold only in the immediate firing motoneurons, thereby making them more excitable than in WT mice. Furthermore, the dendrites of the immediate firing motoneurons are substantially shorter (about 35%) in the mutant than in the WT. In sharp contrast, the excitability of the delayed firing motoneurons is unchanged and the dendritic tree is nearly unaffected (the dendrites only undergo a 10% elongation). These results allow for reconsidering the link between hyperexcitability and degenerescence of the motoneurons
Lindberg, Alexandra, and Nelly Lindblom. "Personers upplevelser av att leva med sjukdomen ALS (amyotrofisk lateralskleros) : En litteraturöversikt." Thesis, Ersta Sköndal högskola, Institutionen för vårdvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-4595.
Full textBackground: ALS is a constant progressive disease that causes reduced muscle function. This continues until the person is no longer able to move or speak and eventually affects the respiratory organs. This will ultimately lead to the person’s death. To suffer from an incurable disease is a life-changing transformation that puts great mental distress on both the affected person and on the person's relatives. Aim: The aim is to describe the experiences of people living with ALS. Method: This literature study has included eleven scientific papers taken from the databases CINAHL Complete and PubMed. The method has been designed by Friberg. The consensus concept the human being has been used. Results: The results of this literature study revealed four themes and two subthemes. These themes were The experience of not being in control, The experience of the physical loss and how to handle it (subtheme), The experience of not knowing what is going to happen (subtheme), The experience of social isolation, How help and information was perceived by the persons with ALS and Persons’ experience of how family relations are affected by ALS. Discussions: The results were discussed based on relevant scientific papers linked to Travelbee's definition of the human being. The dominating factors that were discussed from the results were a concern regarding the future and a negatively changed self-image, to maintain a positive attitude related to hope and isolation.
Muniz, Filho Raimundo Clecio Dantas. "Aplicação de métodos de resolução de curvas multivariada a dados experimentais gerados por diferentes técnicas analíticas = uma visão exploratória da biossíntese da violaceína." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248546.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
Made available in DSpace on 2018-08-19T01:35:46Z (GMT). No. of bitstreams: 1 MunizFilho_RaimundoClecioDantas_D.pdf: 4450185 bytes, checksum: 93734fb6cdec46f7ac2161a230dd978c (MD5) Previous issue date: 2011
Resumo: A aplicação de métodos de resolução de curvas multivariada (MCR-ALS e PARAFAC) a dados de espectroscopia de fluorescência multicomprimento de onda, absorção molecular e cromatografia líquida de ultra eficiência com detecção por espectrometria de massas foi avaliada como um nova e complementar metodologia para se obter informação inicial sobre a biossíntese de produtos naturais. Para demonstrar o poder dessa proposta, a biossíntese da violaceína pela Chromobacterium violaceum foi usada como exemplo. A violaceína é um metabólito secundário que exibe amplo espectro de atividade biológica e o entendimento de sua rota biossintética pode ser de grande interesse para o planejamento de fármacos. Para tanto, uma cultura da C. violaceum foi cultivada em biorreator, onde, a cada duas horas, alíquotas do meio de cultura eram coletadas para subsequentes análises. Na primeira parte deste trabalho, as matrizes de emissão-excitação das amostras revelaram o comportamento dinâmico de fluoróforos envolvidos na biossíntese. O método de análise de fatores paralelos (PARAFAC) foi aplicado para resolver os perfis de fluorescência, onde seis espectros puros de emissão e excitação foram obtidos e suas relações com a biossíntese da violaceína estabelecidas. Na segunda parte, o método de resolução de curvas multivariada por quadrados mínimos alternados (MCR-ALS) foi utilizado para extrair informações simultâneas dos dados gerados por UV-VIS, fluorescência e UPLC-MS das amostras coletadas durante a biossíntese. Cinco compostos foram resolvidos e informações espectrais e temporais dessas espécies foram obtidas. Compostos com massas moleculares de 453, 465 e 479 u, até então não reportados na literatura como intermediários dessa biossíntese, foram identificados. Por fim, a metodologia baseada na aplicação de métodos de resolução de curvas MCR-ALS e PARAFAC provou ser uma poderosa ferramenta para investigar a biossíntese de produtos naturais
Abstract:The application of Multivariate Curve Resolution methods (MCR-ALS and PARAFAC) into multi-wavelength fluorescence spectroscopy, molecular absorption and ultra-performance liquid chromatography coupled to mass spectrometry data was evaluated as a new and complementary approach for the initial analysis of the biosynthesis of fluorescent natural products. To demonstrate the usefulness of this methodology, violacein biosynthesis by Chromobacterium violaceum was used as an example. Violacein is a secondary metabolite that exhibits a broad spectrum of biological activities and the understanding of its biosynthetic pathway can be of great interest for drug design. Therefore, a culture of C. violaceum was grown in a bioreactor from which aliquots were collected every two hours for subsequent analysis. In the first part of this work, the excitation¿emission matrices of the samples have revealed the dynamic behavior of the fluorophores involved in this biosynthesis. The parallel factor analysis (PARAFAC) method was applied to resolve the fluorescence profiles where six pure emission and excitation spectra were obtained and their relationship with violacein biosynthesis established. In the second part, the multivariate curve resolution procedure based on alternating least squares optimization (MCR-ALS) was used for extracting information from fused data (UV-VIS absorption, fluorescence and ultra-performance liquid chromatography with mass spectrometry) gathered during the violacein biosynthesis. Five chemical components were resolved from which spectral and temporal information were obtained. Compounds with molecular masses 453, 465 and 479 u, until now unreported as intermediate of this biosynthesis, were identified. Finally, the methodology based on the application of curve resolution methods PARAFAC and MCR-ALS has proven to be a unique and powerful tool to achieve a deeper insight of the biosynthesis of natural products
Doutorado
Físico-Química
Doutor em Ciências
Albracht, Frank. "Metallfasern als schallabsorbierende Strukturen und als leitfähige Komponenten in Verbundwerkstoffen." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973103582.
Full textAlbracht, Frank. "Metallfasern als schallabsorbierende Strukturen und als leitfähige Komponenten in Verbundwerkstoffen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1098897061531-56925.
Full textCloer, Ernst. "Der Lehrer als "bedeutungsvoller Anderer"; die Lehrerin als "bedeutungsvolle Andere"." Universität Potsdam, 1996. http://opus.kobv.de/ubp/volltexte/2005/485/.
Full textBernhard, Eric M. "Kunst als Kapitalanlage : Kunstmarktfonds als Verbindung zwischen Kunst- und Kapitalmärkten /." Wiesbaden : Dt. Univ.-Verl, 2005. http://www.gbv.de/dms/zbw/479055459.pdf.
Full textForsström, Adam. "Konsum als diskursiver Hintergrund in Lehrwerken für Deutsch als Fremdsprache." Thesis, Uppsala universitet, Institutionen för moderna språk, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325594.
Full textAlbracht, Frank. "Metallfasern als schallabsorbierende Strukturen und als leitfähige Komponenten in Verbundwerkstoffen." Doctoral thesis, Technische Universität Dresden, 2003. https://tud.qucosa.de/id/qucosa%3A24389.
Full textSchneider, Ulrich Johannes. "Ordnung als Schema und als Operation: die Bibliothek Herzog Augusts." Foucault und die Künste / hrsg. von Peter Gente. Frankfurt am Main : Suhrkamp, 2004, S. 315-338 ISBN 3-518-29267-6, 2004. https://ul.qucosa.de/id/qucosa%3A12775.
Full textHartkopf, Dorothea. "Der Orientierungskurs als neues Handlungsfeld des Faches Deutsch als Zweitsprache." Münster New York, NY München Berlin Waxmann, 2010. http://d-nb.info/999243217/04.
Full textKeskin, Isil. "SOD, ORF and ALS: On the role of SOD1 and C9ORF72 in the pathogenesis of ALS." Doctoral thesis, Umeå universitet, Klinisk neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124917.
Full textStrasser, Florian. "Unternehmensfernsehen als Kommunikationsinstrument." St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/04608733001/$FILE/04608733001.pdf.
Full textLieber, Gabriele. "Kunstpädagogik als Menschenbildung." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973178426.
Full textLessner-Sturm, Jan H. "Gewerkschaften als Arbeitgeber /." München : ZAAR-Verl, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018768129&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textMeyer, Kathrin. "Nanomaterialien als Fliessregulierungsmittel." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968366384.
Full textSchill, Oliver. "Ökobilanzen als Controllinginstrument." Dresden : TU, Fak. Wirtschaftswiss., Professur für Betriebswirtschaftslehre, Betriebliche Umweltökonomie, 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10673685.
Full textSchemitsch, Markward. "Identitätsdaten als Persönlichkeitsgüter." [S.l. : s.n.], 2005. http://elib.tu-darmstadt.de/diss/000515.
Full textBleses, Helma. "Patientenorientierung als Qualitätsmerkmal." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974978027.
Full textIrrgang, Bernhard. "Medizin als Technoscience." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1223716499235-10305.
Full textOver the past 20 years, American philosopher Don Ihde has developed a concept of technoscience, based on Heidegger's philosophy of technology, to emphasise the technological dimension of natural history, natural science and their cultural context. Both Heidegger and Ihde limit the technoscience approach to modern experimental natural science. However, technoscience should also embrace essential areas of medicine, albeit with decidedly technical objectives. Three paradigms have evolved for the discussion in bioethics: (1) the ethics of conservative protection of life; (2) the ethics of pragmatic healing and betterment, including innovative applications of modern biotechnology within a framework of action centred on the human body; (3) the position and theses of liberal eugenics
Bürger, Thomas. "Geld als Geschichtsquelle." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1244024062265-25774.
Full textSchill, Oliver. "Ökobilanzen als Controllinginstrument." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1058872326328-99042.
Full textNitzschke, Katrin. "Bibliotheken als Kunstsammlungen." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-25828.
Full textRuoff, Michael. "Technik als Möglichkeit." Doctoral thesis, Universitätsbibliothek Chemnitz, 2000. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200000721.
Full textCramer, Franz Anton. "Geschichte als Einzelfall." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-70283.
Full textMolor-Erdene, Sanjaadorj. "Wissensethik als Kulturethik." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-68083.
Full textKerscher, Tobias. "Stickstoffheterocyclen als Chelatliganden." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-120858.
Full textSemprún, Jorge. "Philosophie als Überlebenswissenschaft." Thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2007/1350/.
Full textJungmann, Max. "Maimonides als Arzt." Universität Potsdam, 2001. http://opus.kobv.de/ubp/volltexte/2008/2358/.
Full textBöttger, Katrin. "Ostpolitik als Nachbarschaftspolitik." Universität Potsdam, 2006. http://opus.kobv.de/ubp/volltexte/2006/1010/.
Full textInsgesamt haben sich Wissenschaftler und Politiker aus Deutschland, Österreich, Polen, Finnland und Tschechien beteiligt. Die Debatte schließt mit Schlussbemerkungen des Initiators.
Ulrich Best, Katrin Böttger, Vladimir Handl, Heinz Timmermann, Christian Wipperfürth, Sabina Wölkner, Gesine Schwan, Dieter Segert, Beata Wilga, Markus Löning und Ole Diehl, Angelica Schwall-Düren, Wolfgang Gehrcke und Jochen Franzke
Wagner, Dieter. "Personalbeurteilungssysteme als Führungsinstrument." Universität Potsdam, 1985. http://opus.kobv.de/ubp/volltexte/2011/5048/.
Full textMau, Steffen. "Grenzen als Sortiermaschinen." Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2013/6346/.
Full textLandgraf, Jörg. "Politik als Theater." Master's thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230345.
Full textRenner, Martin Ulrich. "Gelatinefilme als Arzneistoffträger." kostenfrei, 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973391847.
Full textKleine-Benne, Birte. "Kunst als Handlungsfeld." Berlin Logos-Verl, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2900769&prov=M&dok_var=1&dok_ext=htm.
Full textWiederkehr, René. "Fairness als Verfassungsgrundsatz." Bern Stämpfli, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2846060&prov=M&dok_var=1&dok_ext=htm.
Full textLey, Christian. "Ministerbefangenheit als Verfassungsproblem." Berlin Ducker und Humblot, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2878389&prov=M&dok_var=1&dok_ext=htm.
Full textNaus, Silke. "Softwareerstellung als Projekt." Hamburg Kovač, 2005. http://www.verlagdrkovac.de/3-8300-2326-X.htm.
Full textGeibel, Stefan J. "Treuhandrecht als Gesellschaftsrecht." Tübingen Mohr Siebeck, 2006. http://d-nb.info/986927120/04.
Full textYi, Wŏn-u. "Privatisierung als Rechtsproblem /." Köln ;Berlin [u.a.] : Heymann, 1997. http://www.gbv.de/dms/spk/sbb/recht/toc/274386291.pdf.
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