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Dissertations / Theses on the topic 'Alphavirus'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Berglund, Peter. "Alphavirus vectors as recombinant vaccines /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2657-3.

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2

Skoging, Nyberg Ulrica. "Protein interactions involved in alphavirus assembly /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4329-x/.

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3

Shabman, Reed Solomon Heise Mark T. "Alphavirus evasion of type I interferons." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1879.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.
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4

Lim, Elisa X. "Host-pathogen interactions during alphavirus infection." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/410163.

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Arthritogenic alphavirus infection causes debilitating pain in the joints and muscles with many patients experiencing such symptoms chronically. However, there is insufficient evidence to explain the underlying causes behind symptoms of persistent arthralgia and myalgia. Joint-associated tissues are the main site of inflammation during alphavirus infection, and it has been shown that alphaviruses induce damage to the cartilage and synovium. Therefore, the cell types present in these tissues play critical roles in disease pathogenesis. The findings described in this thesis contribute to the gen
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5

Li, Ke-Jun. "Semliki forest virus-derived packaging system for production of retroviral vectors /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3268-9/.

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6

Gershy-Damet, Guy-Michel. "Etude épidémiologue et virologique des infections à arbovirus en Côte d'Ivoire : aspects ultrastructuraux de l'infection expérimentale du nourrisson par la souche vaccinale antiamarile." Aix-Marseille 2, 1985. http://www.theses.fr/1985AIX21901.

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7

Nubgan, Amer S. "The role of the deubiquitylase MYSM1 during alphavirus infection." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3015357/.

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The members of the genus Alphavirus are positive-sense RNA viruses and it is one of two within the family Togaviridae. Most alphaviruses are predominantly transmitted to susceptible vertebrates by a mosquito vector. Alphavirus disease in humans can be severely debilitating, and depending on the particular viral species, infection may result in encephalitis and possibly life threatening symptoms. Chikungunya virus (CHIKV) is the aetiological agent represents a substantial health burden to affected populations, with clinical symptoms that include severe joint and muscle pain, rashes, and fever,
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8

Plaskon, Nicole Elyse. "The Development of New Tools to Investigate Alphavirus Replication Kinetics." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34787.

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<p>Members of the alphavirus genus pose a serious or potential threat to public health in many areas of the world. Nearly all alphaviruses are maintained in nature by transmission cycles that involve alternating replication in a susceptible vertebrate and invertebrate host. The maintenance of this transmission cycle depends on the establishment of a life-long persistent infection in the invertebrate vector host. Although alphavirus replication has been extensively studied in vertebrate models, the strand-specific replication kinetics of alphaviruses during persistent infections of the inverteb
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9

Belarbi, Essia. "Etude de la physiopathologie des infections à alphavirus arthritogènes par une approche d’imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS073.

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Les alphavirus arthritogènes de la rivière Ross (RRV) et du chikungunya (CHIKV) sont des arbovirus à l’origine de maladies inflammatoires musculosquelettiques chez l'homme. Ils sont largement distribués dans le monde et provoquent périodiquement des épidémies explosives. Les principaux signes cliniques lors d’une infection par un alphavirus arthritogène sont les myalgies, polyarthrites et arthralgies intenses pouvant persister plusieurs mois après l'infection. Les mécanismes de développement de l’infection et des manifestations persistantes sont peu connus. Pour étudier la pathogenèse de l'inf
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10

Castro, Ceyla Maria Oeiras de. "Análise metabolômica de alterações induzidas pelo vírus mayaro em células vero." Faculdade de Medicina de São José do Rio Preto, 2015. http://hdl.handle.net/tede/373.

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Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2017-08-03T11:44:01Z No. of bitstreams: 1 ceylamariaodecastro_tese.pdf: 1353174 bytes, checksum: 1308d049511e8f07c8b5a5d1f5aa3df6 (MD5)<br>Made available in DSpace on 2017-08-03T11:44:01Z (GMT). No. of bitstreams: 1 ceylamariaodecastro_tese.pdf: 1353174 bytes, checksum: 1308d049511e8f07c8b5a5d1f5aa3df6 (MD5) Previous issue date: 2015-09-03<br>This study aimed at assessing the extracellular metabolic profile of Vero cells infected by Mayaro virus. In this metabolomic study, the use of nuclear magnetic resonance associated to multivariat
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11

Mostafavi, Helen. "Adaptive Immunity in Alphavirus-Induced Disease – A Focus on Interleukin-17." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/417290.

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Mosquito-borne arthritogenic alphaviruses such as Ross River virus (RRV) are responsible for outbreaks of arthritic disease in Australia and worldwide. RRV induces the development of painful, incapacitating musculoskeletal inflammation which can last from months to years after initial acute disease, and is mediated by host cellular immune responses. While previous studies have described the role of innate immune responses in RRV infection, the role of adaptive immune responses still remain poorly understood. In addition, no current vaccine or specific-treatment exists, with patients relying on
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12

Wimmer, Wolfgang. "Cytokines in alphavirus induced arthritis as possible targets for novel treatments." Thesis, Curtin University, 2015. http://hdl.handle.net/20.500.11937/48524.

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This study highlighted the involvement of macrophages, muscle cells and adipocytes in the pathogenesis of RRV disease and investigated the release of various cytokines from these cells during infection, such as TNFα, MIF, NO, HMGB proteins, IL-6, IL-18, IL-33, IL-10 and others. Several known cytokine inhibitors were tested for their anti-inflammatory properties in RRV infected cell lines as possible future treatment options. These inhibitors included erythromycin, clarithromycin, roxithromycin, ethyl pyruvate, pentoxifylline and resveratrol.
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13

Moriette, Coralie. "Le virus de la maladie du sommeil des Salmonidés : mise au point d'un ADNc infectieux et obtention d'anticorps monoclonaux." Paris 11, 2005. http://www.theses.fr/2005PA112140.

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Le Virus de la Maladie du Sommeil (VMS) a été caractérisé au laboratoire comme étant le premier alphavirus aquatique appartenant donc à la famille des Togaviridae. Au cours de ce travail de thèse nous avons poursuivi 3 objectifs : (i) élaboration d'un ADNc infectieux, (ii) génération d'un éventail d'anticorps monoclonaux contre les protéines non structurales et structurales du VMS, et cartographie de certains de ces anticorps, (iii) développement de méthodes diagnostiques pour le VMS. (i) Le génome du VMS est un ARN positif de 12 kb environ, entièrement séquencé. Il a été converti en ADNc et c
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14

Li, Changqing. "Insights into mRNA capping enzyme and Macro domain of alpha-like viruses." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4082.

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Alphavirus et virus de l'hépatite E, appartiennent à l'alpha-like supergroupe de virus à ARN simple brin positif. Dans cette thèse, la caractérisation fonctionnelle de l'ARNm plafonnement enzyme et le domaine macro sont abordées, afin d'élucider leur rôle dans la réplication virale et de les évaluer en tant que cibles antivirales possibles.Les alphavirus possèdent un mécanisme unique de coiffe de l'ARNm viral impliquant la protéine non structurale nsP1. Nous présentons ici la caractérisation biochimique de nsP1d'alphavirus et son potentiel comme cible antivirale. Pour cela, différents tests en
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15

Cresson, Marie. "Study of chikungunya virus entry and host response to infection." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1050.

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Les alphavirus sont un groupe de virus enveloppés à ARN simple brin positif retrouvés sur la totalité du globe et responsables de nombreuses maladies humaines et animales. Durant la dernière décennie, une réémergence du virus du chikungunya (CHIKV) a été observée causant de nombreuses épidémies sur tous les continents. Malgré les nombreuses études, les mécanismes moléculaires de réplication du CHIKV et les interactions hôte-virus restent peu caractérisées. L’objectif de mon travail était de mieux comprendre et caractériser l’entrée du virus du chikungunya et les facteurs de l’hôte impliqués da
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16

Fleeton, Marina N. "Genetic vaccination against acute viral disease /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3811-3/.

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17

Duggan, Jacqueline Marie. "Production and evaluation of recombinant single-chain antibodies for the detection of Venezuelan equine encephalomyelitis virus." Thesis, Oxford Brookes University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323908.

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18

Pastorino, Boris. "Etude du complexe protéasique des flavivirus et des alphavirus : caractérisations enzymatiques et recherche de cibles cellulaires." Aix-Marseille 2, 2008. http://www.theses.fr/2008AIX20671.

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19

Serra, Otacília Pereira. "Arbovírus dos gêneros Flavivirus e Alphavirus em culicídeos capturados em Cuiabá, Mato Grosso." Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/694.

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20

Storm, Nadia. "Epidemiology of Sindbis fever in South Africa and development of a real-time pan-alphavirus PCR assay for the detection of Sindbis and other medically important alphaviruses." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/30942.

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The genus Alphavirus in the family Togaviridae consists of approximately 30 single stranded, positive-sense RNA viruses which cause diseases ranging from mild, febrile illness with rash and arthritis to life-threatening encephalitis. Sindbis virus is the prototype virus for this genus and is the most widely distributed alphavirus globally. Little epidemiological data exists for this virus due to inadequate surveillance efforts in most countries, and it is suspected that Sindbis and other alphavirus infections are largely underreported. Additionally, changing patterns of alphavirus infecti
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21

Zweerink, Susanne [Verfasser]. "Investigations into Interferon Response of Novel Bat Cell Cultures upon Alphavirus Infection / Susanne Zweerink." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1044970987/34.

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22

Herath, Tharangani K. "Cellular and molecular pathogenesis of Salmonid alphavirus 1 in Atlantic salmon Salmo salar L." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/2325.

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Salmonid alphaviruses (SAV) are a group of viruses that have recently emerged as a serious threat to the salmonid aquaculture industry in Europe. Over recent years, diseases caused by SAV have severely hampered the Scottish, Irish and Norwegian Atlantic salmon industry, and are considered to be among the major economically important viral diseases affecting the industry at present. Amongst the six subtypes characterised so far, Salmonid alphavirus 1 (SAV1) causes severe pathology in the heart, pancreas and the skeletal muscle of Atlantic salmon leading to death and growth retardation in the af
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23

Ferguson, Mhairi Catriona. "Mammalian cell stress responses during Semliki Forest virus infection." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8188.

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Virus infection of mammalian cells induces several stress mechanisms, including autophagy and type-I interferon (IFN). Autophagy, a cellular homeostatic mechanism in which intracellular materials are sequestered into double-membrane vesicles and targeted to lysosomes for degradation, is also activated in response to virus infection. Most positive single-stranded RNA viruses studied to date utilise autophagy to increase virus replication. IFN is a potent anti-viral mechanism, which can be divided into two parts: (i) induction and secretion of IFN and (ii) IFN signalling and priming of uninfecte
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24

Rückert, Claudia. "Alphavirus and flavivirus infection of Ixodes tick cell lines : an insight into tick antiviral immunity." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10063.

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Arthropod-borne viruses, arboviruses, have the ability to replicate in both vertebrates and invertebrates and are transmitted to susceptible vertebrate hosts by vectors such as mosquitoes and ticks. Ticks are important vectors of many highly pathogenic arboviruses, including the flavivirus tick-borne encephalitis virus (TBEV) and the nairovirus Crimean-Congo haemorrhagic fever virus. In contrast, alphaviruses are principally mosquito-borne and have been isolated only rarely from ticks; ticks have not been implicated as their vectors. Nevertheless, the alphavirus Semliki Forest virus (SFV) repl
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25

Zuchi, Nayara. "Investigação molecular de alphavirus em pacientes febris durante epidemia de dengue em Mato Grosso, Brasil." Universidade Federal de Mato Grosso, 2014. http://ri.ufmt.br/handle/1/493.

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26

Mai, Junbo. "Alphavirus nsP2 interacts with Host Pathways for Viral Minus-Strand Synthesis and Replication Complex Stability." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1262819232.

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27

Boussier, Jeremy. "Chikungunya Virus Superinfection Exclusion and Defective Viral Genomes : Insights into Alphavirus Regulation of Genetic Diversity." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC181/document.

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Les arbovirus (dont le virus chikungunya, CHIKV) sont responsables de millions d'infections chaque année ; aucun vaccin n'est encore approuvé, et les traitements disponibles restent limités. De part leur circulation constante entre le moustique et l'humain, leur adaptation rapide à différents hôtes est un facteur clé pour leur pathogenèse. Le taux d'erreur particulièrement élevé de leur polymérase ARN permet une rapide diversification génique qui conduit à la génération d'un nuages de mutants, appelée quasi espèce. Les quasi espèces contiennent non seulement des génomes mutés, mais aussi des A
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28

Aguilar-Luis, Miguel Angel, Valle-Mendoza Juana del, Isabel Sandoval, et al. "A silent public health threat: emergence of Mayaro virus and co-infection with Dengue in Peru." BioMed Central Ltd, 2021. http://hdl.handle.net/10757/655809.

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Objective: To describe frequency and clinical characteristics of MAYV infection in Piura, as well as the association of this pathogen with DENV. Results: A total of 86/496 (17.3%) cases of MAYV were detected, of which 54 were MAYV mono-infection and 32 were co-infection with DENV, accounting for 10.9% and 6.4%, respectively. When evaluating monoinfection by MAYV the main groups were 18–39 and 40–59 years old, with 25.9% and 20.4% respectively. Co-infections were more common in the age group 18–39 and those > 60 years old, with 34.4% and 21.9%, respectively. The most frequent clinical presentat
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29

Wiley, Michael R. "New tools for the study of virus-vector interactions in mosquitoes." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77343.

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Mosquito-borne diseases continue to be a burden to global health. The viruses that cause these diseases are maintained in nature through a biological transmission cycle involving susceptible vertebrate and mosquito hosts. While knowledge of the interactions occurring between mosquito-borne viruses and vertebrates is considerable, much less is known about the interactions of these viruses with their disease vectors. Studies with Drosophila melanogaster have been important in understanding how insects respond to viral infections. However, mosquitoes and the viruses they vector have co-evolved du
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30

Jaffar-Bandjee, Marie-Christine. "Étude de la physiopathologie de l'infection Chikungunya en phase aiguë et chronique chez l'homme." Phd thesis, Université de la Réunion, 2010. http://tel.archives-ouvertes.fr/tel-00671277.

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Chikungunya est un alphavirus transmis par les moustiques (Aedes) et qui provoque de la fièvre, des éruptions cutanées, des myalgies et des arthralgies. La maladie (CHIKVD) est transitoire, mais des formes sévères menant à des arthrites chroniques incapacitantes ont été signalées. Nous avons dans un premier temps étudié prospectivement les paramètres cliniques et immunologiques associés à la maladie chez des patients hospitalisés et identifiés comme étant 'guéris' ou 'chronique' à M12 après l'infection. Dans la deuxième partie, nous avons observé in vitro les mécanismes et le rôle de l'apoptos
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31

Richartz, Rosaria Regina Tesoni de Barros. "Detecção de anticorpos inibidores de hemaglutinação para Alphavirus em soros de equinos do Estado do Parana." reponame:Repositório Institucional da UFPR, 2012. http://hdl.handle.net/1884/27683.

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Resumo: Foi realizado um inquérito sorológico, em 816 soros de eqüinos de diversas regiões do Estado do Paraná, em 1991, para detectar anticorpos inibidores de hemaglutinação para os vírus das encefalomielites eqüinas leste, oeste e venezuelana. Os resultados obtidos foram de uma prevalência de 30,4% para o vírus da encefalomielite eqüina oeste (WEE), 19,2% para o vírus da encefalomielite eqüina venezuelana (VEE) e 15,3% para o vírus da encefalomielite eqüina leste (EEE). Dos 816 soros analisados pelo teste de inibição da hemaglutinação (Hl), 300 reagiram positivamente, resultando em uma incid
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32

Carrera, J. P., Zulma M. Cucunuba, Karen Neira, et al. "Endemic and epidemic human alphavirus infections in eastern Panama: An analysis of population-based cross-sectional surveys." American Society of Tropical Medicine and Hygiene, 2020. http://hdl.handle.net/10757/655503.

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Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic
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33

Grau, Nina. "Études structurales des conformations post-fusion des protéines d'enveloppe (E1) des alphavirus de la forêt de Semliki, du Chikungunya et de Sindbis : implications pour le mécanisme de fusion." Electronic Thesis or Diss., Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB141.

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Contexte : Le virus du Chikungunya (CHIKV), de la Forêt de Semliki (SFV) et de Sindbis (SINV) appartiennent au genre Alphavirus et sont transmis par des moustiques. CHIKV a provoqué récemment des épidémies planétaires causant de graves maladies. Les alphavirus sont enveloppés d'une membrane lipidique et infectent les cellules par voie d'endocytose ; le milieu acide des endosomes induit la fusion de l'enveloppe virale et de la membrane endosomique, fusion catalysée par la protéine d'enveloppe E1. Celle-ci appartient à la classe II des protéines de fusion, et est repliée en trois domaines (I, II
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34

Rulli, Nestor Ezequiel, and na. "Ross River Virus Infection: Disease Mechanisms and Potential Treatment." University of Canberra. School of Health Sciences, 2007. http://erl.canberra.edu.au./public/adt-AUC20080227.091948.

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Ross River virus (RRV) is a mosquito-borne alphavirus and the aetiological agent of epidemic polyarthritis (EPA). Arthropod borne-Alphaviruses that are related to RRV, such as Chikungunya virus, Sindbis virus and Barmah Forest virus, are usually associated with epidemics of infectious arthritides in different parts of the world. In humans, RRV-induced disease symptoms include fever, rash, myalgia and pain and stiffness of the joints. Muscle and joint pain are the most debilitating symptoms in RRV patients and the best treatment available is non-steroidal anti-inflammatory drugs (NSAID). Previo
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35

Chanel, Vos Chantal. "Etude du rôle de l' acide aminé histidine 230 dans la boucle ij de la protéine E1 du virus de la Forêt de Semliki dans la fusion membranaire virale." Paris 7, 2005. http://www.theses.fr/2005PA077060.

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36

Benmaamar, Rim. "Development and optimization of alphaviral systems for membrane protein functional expression." Strasbourg, 2009. http://www.theses.fr/2009STRA6037.

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37

Morin, Benjamin. "Etude structurale et fonctionnelle de protéines de virus à ARN impliquées dans la réplication virale et la réponse cellulaire à l'infection." Aix-Marseille 2, 2009. http://theses.univ-amu.fr.lama.univ-amu.fr/2009AIX22102.pdf.

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A l’heure actuelle, les études structurales et fonctionnelles sur les virus émergents se limitent à quelques virus dont l’impact sociétal est établi et prévisible. Pourtant, le monde des virus à ARN est très vaste, et présente des potentialités d’émergences en pleine augmentation. Au cours de mon doctorat, j’ai étudié 2 types de protéines impliquées dans la réplication de tels pathogènes viraux. La protéine L des virus à ARN négatif (ARN(‐)) est la polymérase indispensable à la transcription et à la réplication de leur génome. Du fait de la difficulté de production de ces protéines sous forme
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Fitzpatrick, Kelly Ann. "Luminex microsphere immunoassay offers an improved method in testing for antibodies to Eastern Equine Encephalitis virus in sentinel chicken sera." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002480.

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39

Liu, Xiang. "Ross River Virus Interaction with the Type I IFN Pathways." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367506.

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Ross River virus (RRV) belongs to the genus Alphavirus and is a medically important arbovirus that causes musculoskeletal disease in humans with symptoms such as arthralgia, arthritis and myalgia. Disease symptoms consistent with RRV infection were first recorded in 1928 in Australia. Currently, with approximately 5,000 cases of RRV infection reported each year in Australia, RRV is the most widely spread arbovirus throughout the South Pacific region. At present there are no specific therapeutics or vaccines available. RRV disease is treated with analgesics and non-steroidal anti-inflammatory d
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40

Ralambondrainy, Miora. "Caractérisation chimique et biologique de trois huiles essentielles répulsives issues de la biodiversité régionale contre l'alphavirus du Ross River." Thesis, La Réunion, 2017. http://www.theses.fr/2017LARE0018/document.

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Les huiles essentielles de citronnelle (Cymbopogon citratus), de géranium (Pelargonium graveolens) et de vétiver (Vetiveria zizanioides) sont utilisées partout dans le monde pour leur activité répulsive contre les principaux vecteurs (moustiques, tiques) de maladies infectieuses chez l'Homme (paludisme, chikungunya, …). L'application cutanée de ces produits naturels pour éviter le contact avec un vecteur n'avait pas été encore envisagée comme moyen de limiter les premiers stades de l’infection par l'agent pathogène transmis par le vecteur. Pour vérifier cette hypothèse, les travaux ont été con
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41

Brehin, Anne-Claire. "La protéine OAS3 de la voie interferon inhibe la réplication du virus chikungunya dans les cellules humaines." Paris 7, 2008. http://www.theses.fr/2008PA077082.

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Chez l'Homme, l'infection par le virus chikungunya (CHIK), un membre du genre Alphavirus de la famille des Togaviridae, se manifeste classiquement par des arthralgies aiguës. La flambée inattendue de fièvre chikungunya dans les îles de l'Océan Indien en 2006 mis en exergue la nécessité de comprendre la pathogénie de cette maladie peu étudiée. La caractérisation moléculaire de plusieurs isolats cliniques collectés sur l'Ile de La Réunion mis en évidence l'émergence du variant viral E1-226V associé à l'adaptation au vecteur Ae. Albopictus. Pour poursuivre cette caractérisation, nous avons produi
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42

Human, Stacey. "Characterization of zoonotic flavi- and alphaviruses in sentinel animals in South Africa." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/30726.

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In South Africa (SA), the arboviruses West Nile virus (WNV), Wesselsbron virus (WSLV), Sindbis virus (SINV) and Middelburg virus (MIDV) are considered the most important flavi- and alphaviruses. Clinical presentation and importance of these viruses as animal pathogens in SA remains ambiguous. Although widely endemic in SA, lineage 2 (L2) WNV has rarely been associated with cases of neurological disease and was therefore assumed to be non-pathogenic. However, fatal encephalitis in a foal was diagnosed as L2 WNV in SA, 1996, leading to the thought that L2 cases were possibly being missed. As the
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43

Lee, Wai Suet. "Discovery of Novel Markers of Virus Transmission by Mosquitoes." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390018.

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Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Current vector control strategies have been impeded by mosquitoes acquiring resistance to insecticide. Therefore, development of new vector control strategies is urgently needed to complement current strategies. In this thesis, efforts have focused on characterizing the glycan-lectin interactions of Ross River virus (RRV; Togaviridae: Alphavirus) with their mosquito vectors. RRV is the most common arbovirus in Australia that causes clinical manifestations including arthralgia and myalgia
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44

Pinto, Tatiana Priscilla Coelho. "Expressão e purificação da proteína E3 do vírus chikungunya (CHIKV)." Master's thesis, Expressão e purificação da proteína E3 do vírus chikungunya (CHIKV), 2013. http://hdl.handle.net/10362/10528.

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RESUMO: O vírus chikungunya (CHIKV) é um vírus de RNA, com invólucro, da família Togaviridae, transmitido por mosquitos Aedes spp. Distribuído por largas regiões de África e Ásia, causa grandes epidemias de artrite grave. A semelhança de sintomas com outras doenças como a dengue e a malária e a persistência de IgM específicas, dificultam o diagnóstico da infeção por CHIKV. A deteção no sangue de E3, uma glicoproteína viral secretada, a incluir num ensaio imunoenzimático poderá melhorar o diagnóstico nos países onde as técnicas de biologia molecular são de difícil acesso. Para testar a utilidad
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Ferreira, Ramos Ana Sofia. "Inhibitors of the mRNA capping machinery and structural studies on macro domains from alphaviruses." Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/190708_FERREIRARAMOS_112plefdq222vlt303lhj860uuajmi_TH.pdf.

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Les alphavirus comme le virus Chikungunya et le virus de l'encéphalite équine vénézuélienne sont des arbovirus (ré)-émergents. Ils possèdent un mécanisme de coiffe de l’ARNm non conventionnel catalysé par nsP1 et nsP2 pour former une structure cap-0 (m7GpppN-) qui est cruciale pour la réplication. Le coiffage constitue une cible antivirale attractive. NsP1 catalyse trois activités: méthyltransférase, guanylylation de nsP1 (GT), et transfert sur l’ARNm. Nous avons développé un test pour cribler la chimiothèque de composés de Prestwick Chemical® contre l’activité GT de nsP1. 18 composés sont res
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46

Bouraï, Mehdi. "Caractérisation d'un interactome virus-hôte : l'exemple du virus du Chikungunya." Paris 7, 2011. http://www.theses.fr/2011PA077183.

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Récemment, la levée de nombreux verrous technologiques a permis le développement de la « génomique fonctionnelle », désignant l'approche systémique appliquée à la biologie moléculaire et cellulaire. Les virus, parasites intracellulaires obligatoires, interagissent avec de nombreux composants de la cellule afin de se répliquer. Mieux définir les interactions entre les protéines virales et cellulaires permet de mieux comprendre le cycle de réplication et la pathogenèse virale, et ouvre la voie à de nouvelles approches thérapeutiques innovantes. Au cours de mon travail de thèse, j'ai cherché à dé
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Wolf, Stefan. "Novel Approaches in the Treatment of Virus- Induced Inflammatory Disease." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366853.

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This PhD thesis combines four chapters on different fields of basic research and sets the focus on two circulating viruses of global concern, the orthomyxovirus influenza A virus (IAV) and the alphavirus Ross River virus (RRV). The first three chapters include swine influenza A virus (sIAV) surveillance for the detection and characterisation of IAV subtypes, an in vitro high throughput screening (HTS) on host micro RNAs (miRNAs) for the discovery of novel anti-IAV (H7N9) targets and their underlying mechanisms, and an approach to reduce disease pathogenesis in mice infected with H7N9 by target
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Davis, Gustavo Henrique Nolasco Grimmer. "Estudos epidemiológicos sobre arbovírus em populações rurais e urbanas do estado do Amazonas." Universidade Federal do Amazonas, 2009. http://tede.ufam.edu.br/handle/tede/3430.

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Made available in DSpace on 2015-04-22T22:06:36Z (GMT). No. of bitstreams: 1 Dissertacao Final Gustavo Henrique.pdf: 11557113 bytes, checksum: 738eeceeb5f826798bc9ce2b09633f72 (MD5) Previous issue date: 2009-03-06<br>FAPEAM - Fundação de Amparo à Pesquisa do Estado do Amazonas<br>Arbovirosis are currently recognized by the World Health Organization as a global problem. Most arbovirosis are summarized in diseases with acute and nonspecific symptoms such as fever, headache and muscle pain. Although self limited, these symptoms create relevant social and economic impacts. In Brazil, the arbov
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Stretton, Clare. "Alphaviruses and host cell interactions." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441742.

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Morazzani, Elaine M. "Modulation of Alphaviruses by Small RNAs." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/39328.

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Mosquito-borne diseases remain a significant burden on global public health. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle that involves alternating virus replication in a susceptible vertebrate and mosquito host. Although infection of the vertebrate host is acute and often associated with disease, continual transmission of these viruses in nature depends on the establishment of a persistent, nonpathogenic infection in the mosquito vector. It is well known that invertebrates rely on small RNA pathways as an adaptive antiviral defense. The canonical an
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