Relevant bibliographies by topics / Alpha9

Academic literature on the topic 'Alpha9'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Alpha9"

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Morley, Barbara, Sarath Vijayakumar, Deeana Menapace, and Timothy Jones. "Vestibular dysfunction in alpha9 and alpha9/10 knockout mice." Biochemical Pharmacology 86, no. 8 (October 2013): 1236–37. http://dx.doi.org/10.1016/j.bcp.2013.08.061.

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Skoglund, G., A. Basmaciogullari, B. Rouot, JC Marie, and G. Rosselin. "Cell-specific localization of G protein alpha-subunits in the islets of Langerhans." Journal of Endocrinology 162, no. 1 (July 1, 1999): 31–37. http://dx.doi.org/10.1677/joe.0.1620031.

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G protein alpha-subunits are involved in the transduction of receptor-mediated regulation of insulin and glucagon secretions. To get further insight into the status of G proteins in alpha- and beta-cells of the Langerhans islets, we have used immunohistochemistry to study the distribution of alpha-subunits in pancreas sections from the rat. Our results show that only insulin-immunoreactive beta-cells display immunoreactivity for selective antibodies directed against the different members of the Galphas and Galpha12-families (alphas, alphaolf, and alpha12, alpha13 respectively). Immunoreactivities for antibodies directed against members of the Galphaq- and Galphai-families showed a more diverse localization: alpha11 and alphao2 were only detected in glucagon-immunoreactive alpha-cells, whereas alphai1 was detected in all beta-cells but only in a few alpha-cells. Even though beta-cells showed immunoreactivities for alphao-non-isoform-selective antibodies, we could not identify the isoform(s) present using selective alphao1 and alphao2 antibodies. Other members of the Galphai- and Galphaq-families (alphai3, alphat2, alphaz and alphaq) were detected in both alpha- and beta-cells. In conclusion, our findings demonstrate a clear difference in the localization of G protein alpha-subunits between alpha- and beta-cells, suggesting the involvement of specific receptor transduction pathways for the neuronal/hormonal regulation of alpha- and beta-cell functions.
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Simard, Alain, Wei Jiang, and Barbara Morley. "Proinflammatory monocyte production and distribution are modulated by alpha7 and alpha9 nicotinic acetylcholine receptors." Journal of Neuroimmunology 275, no. 1-2 (October 2014): 173–74. http://dx.doi.org/10.1016/j.jneuroim.2014.08.466.

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McIntosh, J. Michael, Nathan Absalom, Mary Chebib, Ana Belén Elgoyhen, and Michelle Vincler. "Alpha9 nicotinic acetylcholine receptors and the treatment of pain." Biochemical Pharmacology 78, no. 7 (October 2009): 693–702. http://dx.doi.org/10.1016/j.bcp.2009.05.020.

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Mostovich, Luydmila A., Tatiana Y. Prudnikova, Aleksandr G. Kondratov, Dina Loginova, Pavel V. Vavilov, Valentina I. Rykova, Sergei V. Sidorov, et al. "Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors." Cell Adhesion & Migration 5, no. 5 (September 2011): 395–401. http://dx.doi.org/10.4161/cam.5.5.17949.

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Holtman, J., L. Dwoskin, E. Wala, P. Crooks, and J. McIntosch. "Novel small molecule alpha9 alpha10 nicotinic receptor antagonists for pain management." Journal of Pain 11, no. 4 (April 2010): S33. http://dx.doi.org/10.1016/j.jpain.2010.01.138.

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Sugahara, Shingo, Kaori Hanaoka, and Nobuchika Yamamoto. "Integrin, alpha9 subunit blockade suppresses collagen-induced arthritis with minimal systemic immunomodulation." European Journal of Pharmacology 833 (August 2018): 320–27. http://dx.doi.org/10.1016/j.ejphar.2018.06.021.

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Pasenkiewicz-Gierula, M., and T. Róg. "Conformations, orientations and time scales characterising dimyristoylphosphatidylcholine bilayer membrane. Molecular dynamics simulation studies." Acta Biochimica Polonica 44, no. 3 (September 30, 1997): 607–24. http://dx.doi.org/10.18388/abp.1997_4409.

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The results of molecular dynamics simulation of fully hydrated dimyristoylphosphatidylcholine (DMPC) bilayer membrane in the liquid-crystalline phase are presented. They show that the probability of a gauche conformation varies periodically along the chain with only a slight increase towards the end of the chain. However, the frequency of transition between conformations increases, due to a decrease in the lifetime of the trans conformation, along the chain. The average lifetimes for trans conformations are in the range of 1-2 x 10(-10) s and for gauche conformations in the range of 4-7 x 10(-11) s. The alpha-chain of the DMPC head group has mainly an extended conformation, due to predominantly trans conformation of alpha5 torsion. The rotational correlation time for the P-N vector is 3.7 ns. The C2-C1-O11-P fragment of the DMPC head group (theta1, alpha1, alpha2 torsions) is rigid while the P-O12-C11-C12 fragment (alpha3, alpha4, alpha5 torsions) is flexible. The lateral diffusion coefficient for DMPC self-diffusion in the membrane is 2 x 10(-7) cm2/s; the rate of transverse diffusion is the same. Large differences in the calculated rotational correlation times for the alpha-, beta-, gamma-chains and for the O21-C1 vector indicate that in the liquid-crystalline bilayer each segment of the DMPC molecule exhibits its own rotational freedom, in addition to its internal flexibility resulting from rotational isomerism. The results obtained in these calculations, although in general agreement with some experimental data, shed new light on the dynamical behaviour of phosphatidylcholine molecules in the bilayer membrane in the liquid-crystalline phase.
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Baumann, Lisa, Vivien Kauschke, Anna Vikman, Lutz Dürselen, Gabriela Krasteva-Christ, Marian Kampschulte, Christian Heiss, Kathleen T. Yee, Douglas E. Vetter, and Katrin Susanne Lips. "Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure." Bone 120 (March 2019): 285–96. http://dx.doi.org/10.1016/j.bone.2018.11.003.

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Jacques, T. S., J. B. Relvas, S. Nishimura, R. Pytela, G. M. Edwards, C. H. Streuli, and C. ffrench-Constant. "Neural precursor cell chain migration and division are regulated through different beta1 integrins." Development 125, no. 16 (August 15, 1998): 3167–77. http://dx.doi.org/10.1242/dev.125.16.3167.

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Proliferation and tangential migration of neural precursor cells are essential determinants of CNS development. We have established cell culture models of both these processes using neural precursor cells grown as neurospheres. The pattern of migration that we observe in these cells is homotypic and occurs in the absence of a glial or neuronal scaffold, and is therefore equivalent to that previously described as chain migration. To determine the role of integrins in proliferation and migration, we have analysed the expression pattern of integrins on neurosphere cells and then performed blocking peptide and antibody experiments. Neurosphere cells express five major integrins, alpha5 beta1, alpha 6Abeta1, alphav beta1, alphav beta5 and alpha vbeta8 and, in addition, express low levels of alpha 6Bbeta1. Chain migration is inhibited by blocking the alpha 6beta1 integrin. Proliferation, by contrast, is inhibited by blocking the other beta1 integrins, alphav beta1 and alpha5 beta1. These results show that integrins are important regulators of neural precursor cell behaviour, with distinct beta1 integrins regulating proliferation and migration. They also demonstrate a novel role for the alpha6 beta1 integrin in the cell-cell interactions underlying homotypic chain migration.
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Dissertations / Theses on the topic "Alpha9"

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Baumann, Lisa [Verfasser]. "Der Einfluss der alpha9- und alpha10-Untereinheit des nikotinischen Acetylcholinrezeptors auf den Knochenstoffwechsel / Lisa Baumann." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1193920868/34.

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Madrid, López Natalia Gabriela. "Ciclo sueño-vigilia de una cepa de ratón Knock-Out para el receptor colinérgico nicotínico alpha9." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/147545.

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Grado de magíster en neurociencias
Los estados de sueño y vigilia son configuraciones estables del Sistema Nervioso que pueden ser influenciados por modificaciones de los sistemas sensoriales. El estudio del ciclo de sueño-vigilia de un ratón genéticamente modificado que carece de un receptor en la cóclea dio resultados que muestran diferencias en la organización de los estados de vigilia y sueño, a demás de distinta duración de los episodios de sueño y enmascaramiento fótico que afecta de manera distinta a los ratones control y genéticamente modificados.
The states of sleep and wakefulness are stable configurations of the nervous system that can be influenced by modifications of the sensory systems. The study of the sleep-wakefulness cycle of a genetically modified mouse that lacks a receptor in the cochlea gave results that show differences in the organization of the sleep and wakefulness states, in addition to different duration of the sleep episodes and the photic masking that affect control mice and genetically modified mice differently.
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BAVO, FRANCESCO. "SUBTYPE-SELECTIVE NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS AND ANTAGONISTS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607332.

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This PhD thesis focuses on two specific targets, belonging to the same receptor class of Nicotinic Acetylcholine Receptors (nAChRs): the α4β2 subtype and the α7 subtype. This elaborate is divided in two parts. The aim of the first part is the design and synthesis of α4β2 selective partial agonists as potential smoking-cessation agents. The aim of the second part is the design and synthesis of α7 antagonists with mitocan properties as antitumoral agents. Part 1. In the first project, a series of 3-nitrophenyl ethers and 3-hydroxyphenyl ethers of (S)-N-methylprolinol bearing bulky and lipophilic substituents at the C5 were designed, synthesized and assayed as putative selective α4β2 ligands. Two of them, 5-substituted with a 6-hydroxy-1-hexynyl, had high α4β2 affinity and increased α4β2/α3β4 selectivity when compared with the correspondent unsubstituted parent compounds. In the second project, each -CH= of the unselective antagonist (S,R)-N-methyl-2-pyrrolidinyl-1,4-benzodioxane and of its epimer at the benzodioxane stereocenter, was replaced by a nitrogen. The resulting four diastereomeric pairs of pyrrolidinyl-pyridodioxanes, also designed as the product of rigidification of the flexible scaffolds of pyridyl ethers of N-methyl prolinol, were studied for their nicotinic affinity at the α4β2 and α3β4. The isosteric -CH= to N substitution was detrimental for all the compounds, with the only exception of N-Methyl-pyrrolidinyl 5-pyridodioxane, with the nitrogen at position 5. Indeed, this ligand had similar affinity to its benzodioxane parent compound, but it had high α4β2/α3β4 selectivity and it was shown to be a selective partial agonist. In the third project, the unselective antagonist (S,R)-N-methyl-2-pyrrolidinyl-1,4-benzodioxane and of its epimer at the benzodioxane stereocenter were substituted at position 5 of the benzodioxane moiety, to explore the possibility of introducing selectivity and/or partial agonist as previously done with -CH= to N replacement. Among the synthesized compounds, (S,S)-N-Methyl-pyrrolidinyl-5-amino-benzodioxane had slightly improved affinity at the α4β2 affinity and highly enhanced α4β2/α3β4 selectivity than the unsubstituted parent compound, and it was shown to be a very potent partial agonist. In the fourth project, we applied computational techniques to support the interpretation of the biological results regarding N-Methyl-pyrrolidinyl 5-substituted benzodioxanes and pyridodioxanes. From these findings, we suggested that partial agonism and α4β2/α3β4 selectivity could be achieved when the benzodioxane scaffold is appropriately substituted with an HBA/HBD system, that can displace a water molecule from a small and hydrophilic subpocket of the binding site. Part 2. Adenocarcinoma and glioblastoma cell lines express α7 and α9-α10 nAChRs, whose activation promotes tumor cells growth. On these cells, the triethylammoniumethyl ether of 4-stilbenol MG624, a known selective antagonist of α7 and α9-α10 nAChRs, has antiproliferative activity. The structural analogy of MG624 with the mitocan RDM- 4’BTPI, triphenylphosphoniumbutyl ether of pterostilbene, suggested us that molecular hybridization among their three substructures might result in novel antitumour agents with higher potency and selectivity. We found that replacement of ethylene with butylene in the triethylammonium derivatives results in more potent and selective toxicity towards adenocarcinoma and glioblastoma cells, which was paralleled by increased α7 and α9-α10 nAChR antagonism and improved ability of reducing mitochondrial ATP production. Further elongation to octylene (26) provided a compound with 40-fold and 10-fold increased antiglioblastoma and antiadenocarcinoma activity respectively, when compared to MG624. Elongation of the alkylene linker was greatly advantageous also for the triphenylphosphonium derivatives. RDM- 4’BTPI did not acquire, as expectable, antinicotinic activity by hybridization with MG624 stilbene scaffold, but it was surpassed in glioblastoma cell viability reduction by its stilbene analogues with > 4C alkylene linker. In particular, the analogue with decylene between stilbenoxyl and triphenylphosphonium head (24) was ten- fold and two-fold more potent than RDM-4’BTPI in reducing glioblastoma cell viability and in increasing ROS production respectively. Overall, the ammonium compound 26 reached antiproliferative activities at glioblastoma and adenocarcinoma cells in the same range of the phosphonium 24, but showed good selectivity against neuroblastoma and healthy mouse astrocytes.
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Spies, Markus. "Nikotinische Rezeptoren nozizeptiver Neurone : Lokalisation und Charakterisierung der {[alpha]3- [Alpha3-] und {[alpha]5-Untereinheiten [Alpha5-Untereinheiten] /." Giessen : VVB Laufersweiler, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016297581&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Ochoa, Vanessa. "Nicotinic Signaling: Alpha3 Beta4 Heteromers, Alpha5 Subunits, And The Prototoxin Lypd6b." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/472.

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Prototoxin proteins have been identified as members of the Ly6/uPAR super family whose three-finger motif resembles that of α-bungarotoxin. Though they are known to modify the function of nAChRs, their specificity is still unclear. Our lab identified three prototoxin proteins in the chicken ciliary ganglion: Ch3ly, Ch5ly, and Ch6ly. Ch6ly was later identified as prostate stem cell antigen (PSCA), and specifically decreased the amount of calcium influx through the homomeric α7 nAChR subtype. I then identifiedCh3ly and Ch5ly as LY6E and LYPD6B, respectively. I focused my attention onLYPD6B because of its expression in the brain. This dissertation tests whether LYPD6Bis a prototoxin protein that specifically co-localizes with and modifies the function of the heteromeric α3β4* nAChRs (the other nAChR subtype expressed in the chicken ciliary ganglia). In the first part of my dissertation I performed intracellular two-electrode voltage clamp on Xenopus oocytes co-expressing human LYPD6B and different stoichiometries of the α3β4* nAChR, these included two (α3)2(β4)3 withβ4−α3−β4−β4−α3 and β4−α3−β4−α3−β4 stoichiometries, two (α3)3(β4)2 with stoichiometries β4−α3−α3−β4−α3 and β4−α3−β4−α3−α3, two (α3β4)2(α5D)β4−α3−α5D−β4−α3 and β4−α3−β4−α3−α5D, and (α3β4)2(α5N) with stoichiometries β4−α3−α5N−β4−α3 and β4−α3−β4−α3−α5N. Concatemeric constructs are designed to link nAChR subunits, thus when translated it is done so as a single polypeptide. LYPD6Bincreased the acetylcholine (ACh) potency and desensitization rate, but decreased the maximum current response (Imax) for the (α3)3(β4)2 nAChR subtype. Yet, LYPD6Bonly decreased the Imax for the (α3β4)2α5 D-variant and not the N-variant (associated with increase nicotine consumption). For the second part of my dissertation, I determined if the expression of LYPD6B correlated with nAChRs in an activity dependent manner. Though LYPD6B mRNA expression correlates with nAChR subunit mRNA expression levels, it seemed to be independent of nAChR activity. To determine if fluorescent colocalization occurs between LYPD6B and a specific nAChR subtype, I genetically engineered LYPD6B to express a human influenza hemagglutinin (HA) epitope tag and cloned into a chicken retrovirus. LYPD6B was shown to co-localize only with the α3β4*heteromeric and not the homomeric α7 nAChRs, in a nAChR activity dependent manner. This study adds to the complexity of a prototoxin’s function by suggesting that the specificity is dependent on nAChR type and stoichiometry. It is the first in identifying a prototoxin protein, LYPD6B, which specifically modulates the function of the(α3)3(β4)2 and (α3β4)2(α5 D-variant) heteromeric nAChR subtypes. For the (α3β4)2(α5D-variant) nAChR subtype LYPD6B decreased the Imax. Such observation may be telling of a novel mechanism involved with nicotine dependence. For the(α3)3(β4)2 nAChR subtype LYPD6B increases its ACh sensitivity, desensitization rate, while decreasing Imax. Additionally, the co-localization of LYPD6B and α3β4* nAChRsin the lack of nAChR activity highlights the relevance of the functional effects α3β4*nAChRs exhibit due to LYPD6B. Such relevance may be the utilization of limiting Ach amounts.
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Xu, Xiaohong. "Shared long-range regulatory elements coordinate expression on the nAChR beta4/alpha3/alpha5 cluster." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1157660172.

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Xu, Xiaohong. "SHARED LONG-RANGE REGULATORY ELEMENTS COORDINATE EXPRESSION OF THE NACHR BETA4/ALPHA3/ALPHA5 CLUSTER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1157660172.

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Schäfer, Heike. "Untersuchung der Proteinalterung am Beispiel des [alpha]A-Crystallins [alphaA-Crystallins] der Augenlinse mittels proteomanalytischer Methoden." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972090770.

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Ponchel, Guillaume. "Etudes structurales et fonctionnelles de deux alpha-galactosidases actives sur les antigènes B et alpha3 Gal." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4017.

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Les conversions enzymatiques des antigènes du système des groupes sanguins ABO et de l'antigène majeur de xénotransplantation α3Gal représentent des alternatives thérapeutiques afin d'améliorer l'approvisionnement des hôpitaux en sang de groupe O et la transplantation d'organes. La famille GH110 des glycoside hydrolases comprend des enzymes actives sur les antigène B et α3Gal à pH neutre et fonctionnant avec un mécanisme catalytique par inversion. La sous‐famille GH110_A regroupe des membres actifs exclusivement sur l'antigène B, tandis que la sous‐famille GH110_B regroupe des membres actifs sur les antigènes B et α3Gal. Le travail présenté dans ce manuscrit décrit les études structurales et fonctionnelles de deux α‐galactosidases, BtGal110A (GH110_A) et BtGal110B (GH110_B), de la famille GH110 provenant de la bactérie commensale Bacteroides thetaiotaomicron et représentatives des chacune des ces deux sous‐familes. La spécificité de substrat et la grande efficacité catalytique de ces enzymes à pH neutre ont été confirmées grâce à des oligosaccharides mimant l'extrémité des antigènes B et α3Gal. BtGal110A et BtGal110B se replient en hélice β droite et se distinguent d'autres protéines au repliement similaire par la présence de deux domaines additionnels qui adoptent un repliement en demi tonneau β et participent à l'architecture du site actif. La machinerie catalytique de BtGal110A et BtGal110B est constituée de trois acides aspartiques, semblable à celle des enzymes des familles GH28 et GH49, qui partagent la même repliement en hélice &#946
Enzymatic conversions of the ABO blood group antigens and of the major xenotransplantation α3Gal antigen represent therapeutic alternatives intended to improve supply of hospitals with requested blood type O and organs. The family GH110 of glycoside hydrolases includes enzymes active towards B and α3Gal antigen within neutral pH and employs an inverting catalytic mechanism. The GH110_A subfamily gathers enzymes with exquisite substrate specificity towards the B antigen, while the GH110_B subfamily gathers enzymes active towards the B and the α3Gal antigens. The present manuscript describes the functional and structural studies of two α‐galactosidases BtGal110A (GH110_A) and BtGal110B (GH110_B) from the commensal bacteria Bacteroides thetaiotaomicron, two representative members of each of these two subfamilies. The substrate specificity and high catalytic efficiency of these enzymes at neutral pH were confirmed using oligosaccharides corresponding to the terminal carbohydrate sequences of the B and α3Gal antigens. BtGal110A and BtGal110B contain a right‐handed β‐helix, but he presence of two additional domains tfolded as half β‐barrels, which participate to the architecture of the active site distinguishes BtGal110A and BtGal110B fro other related glycoside hydrolases. The catalytic machinery consists of three aspartic acids, reminiscent of that of enzymes from the GH28 and GH49 families, which share a similar β‐helix fold. Our observations support the membership of family GH110 to the clan‐N of glycoside hydrolases
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Solda', G. M. E. A. "Alpha3 and alpha5 neuronal nicotinic receptor subunit genes : a case of tail-to-tail overlap in humans." Doctoral thesis, Università degli Studi di Milano, 2005. http://hdl.handle.net/2434/47108.

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Natural antisense transcripts, because of their potential to form double-stranded RNA (dsRNA) molecules, recently emerged as a mechanism acting on eukaryotic gene regulation at multiple levels. CHRNA3 and CHRNA5, coding for alpha3 and alpha5 subunits of the neuronal nicotinic acetylcholine receptor, have been reported to overlap at their 3'ends in human and bovine genomes. The general goal of this PhD project was the structural and functional study of this overlap. A fine characterization of human CHRNA3 and CHRNA5 alternative transcripts allowed a more precise definition of the overlap extent and highlighted a complex web of possible sense-antisense interactions among overlapping mRNAs. An RNase protection-based approach was used to detect in vivo RNA-RNA duplexes of CHRNA3 and CHRNA5 transcripts, which resulted to be present in human but not in bovine cells. Furthermore, levels of overlapping transcripts were determined by real-time RT-PCR both in humans and in cattle. Finally, some possible functional consequences of this overlap were explored.
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Books on the topic "Alpha9"

1

Hawley, Francesca. Alpha vs. alpha. Akron: Ellora's Cave Publishing Inc., 2011.

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Alphas. New York: Little, Brown, 2009.

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Kagaku Busshitsu Hyōka Kenkyū Kikō and Shin Enerugī Sangyō Gijutsu Sōgō Kaihatsu Kikō (Japan), eds. [Alpha]-mechirusuchiren: [Alpha]-Methylstyrene. Tōkyō: Seihin Hyōka Gijutsu Kiban Kikō Kagaku Busshitsu Hyōka Kenkyū Kikō, 2009.

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(Museum), Animation-recherche-confrontation, ed. Alpha. Zürich: JRP/Ringier, 2005.

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Rucka, Greg. Alpha. New York: Mulholland Books, 2012.

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Alpha. Taylorville, IL: Oak Tree Press, 2012.

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Arsenault, Isabelle. Alpha. Somerville, Massachusetts: Candlewick Press, 2015.

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Galanē-Karampa, Lina. Alpha. Athēna: Prosperos, 1988.

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Anderson, Felix. Alpha among Alphas. Primedia eLaunch LLC, 2022.

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How To Meet Your Alpha: Alpha Singles, Cruising with Alphas. CreateSpace Independent Publishing Platform, 2018.

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Book chapters on the topic "Alpha9"

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Tulchinsky, Igor. "Introduction to Alpha Design." In Finding Alphas, 1–5. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch1.

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Yan, Peng. "Backtest - Signal or Overfitting." In Finding Alphas, 55–59. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch10.

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Wan, Peng. "Alpha and Risk Factors." In Finding Alphas, 61–64. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch11.

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Aron, Ionut. "The Relationship between Alpha and Portfolio Risk." In Finding Alphas, 65–70. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch12.

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Khan, Hammad. "Risk and Drawdowns." In Finding Alphas, 71–77. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch13.

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Li, Weijia. "Data and Alpha Design." In Finding Alphas, 79–83. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch14.

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Fang, Zhuangxi. "Statistical Arbitrage, Overfitting, and Alpha Diversity." In Finding Alphas, 85–87. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch15.

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Kozlov, Michael. "Techniques for Improving the Robustness of Alphas." In Finding Alphas, 89–91. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch16.

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Huang, Yu. "Alphas from Automated Search." In Finding Alphas, 93–95. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch17.

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Mahajan, Sunny. "Algorithms and Special Techniques in Alpha Research." In Finding Alphas, 97–99. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119057871.ch18.

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Conference papers on the topic "Alpha9"

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Mysliwiec, M., D. Alderson, L. Poller, and P. Ackrill. "PROTEIN C AND OTHER CLOTTING STUDIES IN MEMBRANOUS AND NON-MEMBRANOUS GLOMERULONEPHRITIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644310.

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The occurrence of thrombosis in the nephrotic syn drome has long been known. Thrombotic complications are predominantly associated with membranous glomerulonephritis (MG). The aim of the present work was to study whether the tendency of nephrotic patients with MG to thrombotic episodes could be attributed to a hypercoagulable state. Thirty consecutive patients with the nephrotic syndrome were studied. Of these 17 suffered from MG and 13 had other forms of glomerulonephritis. The control group consisted of 10 healthy volunteers. In addition to standard coagulation assays, we studied: soluble fibrin monomer complexes (FM test, Boehringer), fibrin monomer polymerization, factor VIII:C, factor VIII:vWF, anti thrombin III (AT III) and alpha2 antiplasmin (alpha2AP) using chromogenie substrates; the levels of AT III and alpha2 AP were measured immunologically; beta thromboglobulin (BTG), platelet factor 4 and fibrinopeptide A (FPA) using radioimmunoassay kits; protein C was studied functionally and immunologically. There was a significant shortening of the prothrombin time and activated partial thromboplastin time, increase in alpha9 AP, factor V111:vWF, FPA and BTG in nephrotic patients associated with in or eases in both functional and imminclogical protein C levels and impairment of fibrin polymerization. FM test was negative in all but one of the patients. None of the coagulation tests showed a significant difference in the two nephrotic groups. High protein C and impaired polymerization may be considered as mechanisms counteracting disclosed hypercoagulability in the nephrotic syndrome.
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Wei, Po-Li, Chin-Sheng Hung, and Yu-Jia Chang. "Abstract 456: The Alpha9 nicotinic acetylcholine receptor is the key mediator In nicotine-enhanced cancer metastasis in breast cancer cells." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-456.

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Dittmaier, Stefan, Alexander Huss, and Christian Schwinn. "O(alpha*alphas) corrections to Drell-Yan processes in the resonance region." In 11th International Symposium on Radiative Corrections (Applications of Quantum Field Theory to Phenomenology). Trieste, Italy: Sissa Medialab, 2014. http://dx.doi.org/10.22323/1.197.0020.

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Webster, Jeffrey A., Alexander Hagen, Brian C. Archambault, Nicholas Hume, and Rusi Taleyarkhan. "High Efficiency Gamma-Beta Blind Alpha Spectrometry for Nuclear Energy Applications." In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30821.

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A novel, Centrifugally Tensioned Metastable Fluid Detector (CTMFD) sensor technology has been developed over the last decade to demonstrate high selective sensitivity and detection efficiency to various forms of radiation for wide-ranging conditions (e.g., power level, safeguards, security, and health physics) relevant to the nuclear energy industry. The CTMFD operates by tensioning a liquid with centrifugal force to weaken the bonds in the liquid to the point whereby even a femto-scale nuclear particle interactions can break the fluid and cause a detectable vaporization cascade. The operating principle has only peripheral similarity to the superheated bubble chamber based superheated droplet detectors (SDDs); instead, CTMFDs utilize mechanical “tension pressure” instead of thermal superheat offering a lot of practical advantages. CTMFDs have been used to detect a variety of alpha and neutron emitting sources in near real-time. The CTMFD is selectively blind to gamma photons and betas allowing for detection of alphas and neutrons in extreme gamma/beta background environments such as spent fuel reprocessing plants or under full power conditions within an operating nuclear reactor itself. The selective sensitivity allows for differentiation between alpha emitters including the isotopes of Plutonium. Mixtures of Plutonium isotopes have been measured in ratios of 1:1, 2:1, and 3:1 Pu-238:Pu-239 with successful differentiation. Due to the lack of gamma-beta background interference, the CTMFD’s LLD can be effectively reduced to zero and hence, is inherently more sensitive than scintillation based alpha spectrometers or SDDs and has been proven capable to detect below femtogram quantities of Plutonium-238. Plutonium is also easily distinguishable from Neptunium making it easy to measure the Plutonium concentration in the NPEX stream of a UREX reprocessing facility. The CTMFD has been calibrated for alphas from Americium (5.5 MeV) and Curium (∼6 MeV) as well. The CTMFD has furthermore, recently also been used to detect spontaneous and induced fission events which can be differentiated from alpha decay allowing for detection of fissionable material in a mixture of isotopes. This paper discusses these transformational developments which are also being entered for real-world commercial use.
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Puinean, Mirel. "Allosteric modulation of tick nicotinic acetylcholine receptor alpha 5 and alpha6 by spinosad." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.91232.

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Progri, Ilir F. "Description of VBOC2(alpha1,alpha2) GMGM Special Cases Waveforms ACF---Theory, Computation, Simulations, and Animation." In 2020 International Technical Meeting of The Institute of Navigation. Institute of Navigation, 2020. http://dx.doi.org/10.33012/2020.17212.

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Johnson, Jeremy, Piotr Richahou, and B. Mark Evers. "Abstract 93: AMPK alpha1 and AMPK alpha 2 control TNBC proliferation through cell cycle regulation." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-93.

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Dittmaier, Stefan, Alexander Huss, and Christian Schwinn. "O(alpha_s alpha) corrections to Drell-Yan processes in the resonance region." In Loops and Legs in Quantum Field Theory. Trieste, Italy: Sissa Medialab, 2014. http://dx.doi.org/10.22323/1.211.0045.

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Batalla Toro, Luis F., Simon L. Reid, Alfredo Salcines Tudela, and Duncan Graham. "Integrated Decommissioning of a Pentagon Shaped Production Semisubmersible in the UK: A Unique Challenge." In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-77831.

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Between 1969 and 1977, eleven semisubmersible drilling platforms were designed and built with an innovative pentagon shaped hull, specifically to work in the harsh environment of the North Sea. One of the drilling rigs, the Alexander L. Kielland, was converted soon after construction into an accommodation platform (flotel) and failed catastrophically in 1980. Another, the Pentagon 83 “Drillmaster” (renamed as Buchan Alpha), was being converted to a Floating Production Unit at the time of the disaster. The structure of Buchan Alpha was significantly modified during the conversion of the platform so that it benefited from the lessons learnt following the Alexander L. Kielland accident to ensure that the same sequence of events could not be repeated. This technical paper objective is to explain the integrated decommissioning process of the Buchan Alpha in the UK after more than 40 years since being built and more than 35 years of successful operation since it was converted to a Floating Production Unit, and how the features of its original design have accompanied the platform through the decommissioning process. The scope covers all phases of Buchan Alpha decommissioning from the detailed planning and preparation, the suspension of production up to the dismantling and recycling process. Significant challenges for the decommissioning team included the requirement to preserve the operational status of the subsea infrastructure for potential future field redevelopment and the diver disconnection of the subsea wells. Buchan Alpha’s deep draught presented limitations on the selection of dismantling and recycling yards due to quayside water depths. Complex ballasting operations and removal of the thruster’s propellers were required to facilitate the platform berthing at the quayside. Key lessons learned applicable for future decommissioning of floating production facilities will be shared.
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Wachtfogel, Yanina T., Peter C. Harpel, L. Henry Edmunds, and Robert W. Colman. "FORMATION OF Cl -Cl INHIBITOR AND KALLIKREIN-Cl INHIBITOR COMPLEXES DURING CARDIOPULMONARY BYPASS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642900.

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Cardiopulmonary bypass prolongs bleeding time and increases postoperative blood loss. Contact of blood with synthetic surfaces during extracorporeal circulation leads to major qualitative and quantitative alterations in both platelets and neutrophils. Activation of platelets results in thrombocytopenia, decreased sensitivity of platelets to aggregating agents, decreased alpha2-adrenergic and fibrinogen receptors, secretion of thromboxane B2, and depletion of alpha-granule protein contents. Neutrophils,under similar conditions, have also been shown to release their specific granule protein, lactoferrin, and their azurophilic granule enzyme, elastase.We now investigate whether the classical complement, contact, or fibrinolytic pathways have been activated as potential sources of neutrophil agonists. Employing enzyme-linked immunosorbent “sandwich” assays specific for Cl -Cl inhibitor and kalli-krein-Cl inhibitor complexes respectively, we found that plasma levels of both of these formed complexes increased 2fold after clinical cardiopulmonary bypass was completed and reverted to baseline within 24 hours post-operatively. Since these complexes are cleared iji vivo, we investigated their plasma levels during jLn vitro simulated extracorporeal circulation. Over a period of 2 hours, Cl -Cl inhibitor complexes rose from a baseline of 2 + InM to 21 + 2 nM and kalli-krein-Cl inhibitor complexes rose from 2+1 nM to 25 + 5 nM. However, there was no evidence of either in vivo or vitro plasmin-alpha plasmin inhibitor complex formation. These results indicate that activation of the classical pathway of complement and the contact system in plasma may be associated with neutrophil activation seen during clinical cardiopulmonary bypass.
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Reports on the topic "Alpha9"

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Ashman, William P., and Alexander P. Mickiewicz. Computer-Assisted Determination of Minimum Energy Conformations. 4. Alpha1 and Alpha2 Adrenergic Compounds. Fort Belvoir, VA: Defense Technical Information Center, June 1990. http://dx.doi.org/10.21236/ada226811.

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Бас, Світлана Віталіївна, and Катерина Іванівна Словак. Способи опрацювання запитів та характеристика мобільного доступу до Wolfram|Alpha. Видавничий центр ДВНЗ «Криворізький національний університет», December 2014. http://dx.doi.org/10.31812/0564/1081.

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У статті проаналізовано способи опрацювання запитів різних видів до Wolfram|Alpha, зокрема, можливості запитів природною мовою. Надано характеристику мобільному доступу до Wolfram|Alpha, розглянуто формати подання даних: візуальні подання, зображення, HTML, Mathematica Cell, текстові подання, простий текст, MathML, введення Mathematica, виведення Mathematica, audio подання, спеціальні типи виводу Wolfram|Alpha. Метою статті є аналіз та узагальнення можливостей подання запитів до Wolfram|Alpha різними способами та надання характеристики можливостей мобільного доступу до Wolfram|Alpha. Предметом дослідження є Wolfram|Alpha як хмаро орієнтований сервіс навчання математики. При підготовці матеріалу було використано тематичні дослідження та експериментальне дослідження можливостей подання різних типів запитів до Wolfram|Alpha. Висновок: робота Wolfram|Alpha заснована на опрацюванні природної мови (поки тільки англійської), великій бібліотеці алгоритмів і NKS-підході до відповідей на запити. Wolfram|Alpha не видає перелік посилань, що ґрунтується на результатах запиту, а обчислює відповідь, ґрунтуючись на власній базі знань. Сервіс здатен перекладати дані між різними одиницями вимірювання, системами числення тощо.
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Хараджян, Наталя Анатоліївна, and Микола Анатолійович Слюсаренко. Використання web-сервісу Wolfram|Alpha при вивченні фізики. Видавничий центр ДВНЗ «Криворізький національний університет», 2017. http://dx.doi.org/10.31812/0564/1544.

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Метою дослідження є аналіз можливостей використання web-орієнтованої системи Wolfram|Alpha при вивченні фізики. Задачі: розглянути можливості використання web-орієнтованої системи Wolfram|Alpha при вивченні фізики. Об’єктом дослідження є використання систем комп’ютерної математики при вивченні фізики. Предметом дослідження є використання web-орієнтованих систем комп’ютерної математики в процесі вивчення фізики. Для досягнення цілей дослідження використовувалось кілька методів дослідження: аналіз науково-методичної літератури, присвяченій системам комп’ютерної математики, візуалізації отриманих результатів. Результатами дослідження є проаналізовані можливості використання web-орієнтованої системи Wolfram|Alpha при вивченні фізики. Висновки: Web-орієнтовану систему Wolfram|Alpha доцільно використовувати при вивченні фізики в якості допоміжного інструменту при розв’язанні задач, знаходження довідникових відомостей, візуалізації отриманих розв’язків і т.д.
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Barillas, Francisco, and Jay Shanken. Which Alpha? Cambridge, MA: National Bureau of Economic Research, November 2015. http://dx.doi.org/10.3386/w21698.

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Frazzini, Andrea, David Kabiller, and Lasse Pedersen. Buffett's Alpha. Cambridge, MA: National Bureau of Economic Research, November 2013. http://dx.doi.org/10.3386/w19681.

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Chen, Cheng-Che, and Hao-En Lin. Survival Benefits and Bleeding Risk of Anti-VEGF Agents for Renal Cell Carcinoma (RCC): A Updated Systematic Review and Meta-Analysis of Phase 2 and 3 Randomized Clinical Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0007.

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Review question / Objective: To investigate the survival benefits (PFS, DFS, OS) and bleeding risk of the anti-VEGF agents compared with placebo or interferon alpha (IFNa) in patients with RCC. Condition being studied: Part 1. The hazard ratio (HR) of the progression-free survival (PFS) and overall survival (OS) of anti-VEGF agents vs. non/placebo for patients with unresectable, advanced, metastatic, renal cell carcinoma (RCC). Part 2. The HR of the disease-free survival (PFS) and OS of anti-VEGF agents vs. non/placebo for patients with post-nephrectomy RCC (adjuvant use). Part 3. The HR of the PFS and OS of anti-VEGF agents vs. IFN-alpha for patients with RCC. Part 4. The relative risk (RR) of bleeding events of anti-VEGF agents vs. placebo or IFN-alpha for patients with RCC.
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Salmon, R., and O. Hermann. ALPHN: A computer program for calculating ([alpha], n) neutron production in canisters of high-level waste. Office of Scientific and Technical Information (OSTI), October 1992. http://dx.doi.org/10.2172/7147581.

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Salmon, R., and O. W. Hermann. ALPHN: A computer program for calculating ({alpha}, n) neutron production in canisters of high-level waste. Office of Scientific and Technical Information (OSTI), October 1992. http://dx.doi.org/10.2172/10104377.

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McKenzie, George. Rossi Alpha Method. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1148943.

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Swinhoe, Martyn Thomas. UF6 Alpha Spectrometer. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1358155.

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