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Journal articles on the topic "Alpha Transu"
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Pasenkiewicz-Gierula, M., and T. Róg. "Conformations, orientations and time scales characterising dimyristoylphosphatidylcholine bilayer membrane. Molecular dynamics simulation studies." Acta Biochimica Polonica 44, no. 3 (September 30, 1997): 607–24. http://dx.doi.org/10.18388/abp.1997_4409.
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The results of molecular dynamics simulation of fully hydrated dimyristoylphosphatidylcholine (DMPC) bilayer membrane in the liquid-crystalline phase are presented. They show that the probability of a gauche conformation varies periodically along the chain with only a slight increase towards the end of the chain. However, the frequency of transition between conformations increases, due to a decrease in the lifetime of the trans conformation, along the chain. The average lifetimes for trans conformations are in the range of 1-2 x 10(-10) s and for gauche conformations in the range of 4-7 x 10(-11) s. The alpha-chain of the DMPC head group has mainly an extended conformation, due to predominantly trans conformation of alpha5 torsion. The rotational correlation time for the P-N vector is 3.7 ns. The C2-C1-O11-P fragment of the DMPC head group (theta1, alpha1, alpha2 torsions) is rigid while the P-O12-C11-C12 fragment (alpha3, alpha4, alpha5 torsions) is flexible. The lateral diffusion coefficient for DMPC self-diffusion in the membrane is 2 x 10(-7) cm2/s; the rate of transverse diffusion is the same. Large differences in the calculated rotational correlation times for the alpha-, beta-, gamma-chains and for the O21-C1 vector indicate that in the liquid-crystalline bilayer each segment of the DMPC molecule exhibits its own rotational freedom, in addition to its internal flexibility resulting from rotational isomerism. The results obtained in these calculations, although in general agreement with some experimental data, shed new light on the dynamical behaviour of phosphatidylcholine molecules in the bilayer membrane in the liquid-crystalline phase.
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Hunter, Aaron. "When is the now in the here and there? Trans-diegetic music in Hal Ashby’s Coming Home." Alphaville: Journal of Film and Screen Media, no. 3 (August 8, 2012): 36–48. http://dx.doi.org/10.33178/alpha.3.03.
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While it would be a stretch to classify Hal Ashby as a postmodernist filmmaker (with that term’s many attendant ambiguities), his films of the 1970s regularly evince post-Classical stylistic and narrative strategies, including non-linear time structures, inter-textual self-references, open endings, and nuanced subversions of the fourth wall. Ashby’s most consistently playful approach to form comes by way of his integration and development of trans-diegetic musical sequences within his body of work. Music in Ashby films creates a lively sense of unpredictability, and each of his seven films of the 1970s employs this strategy at least once. Moreover, trans-diegetic music in Ashby’s films becomes a device that allows the director to elide moments in time. It functions as an editing tool, creating a bridge between often disparate events. However, it is also a narrative device that both compresses and stretches time, allowing for an on-screen confluence of events that at first appear to take place simultaneously or sequentially, but which actually occur over different moments or lengths of time. Yet while Ashby is not alone as a Hollywood director interested in exploring the formal possibilities that trans-diegesis might bring to his movies, film studies has begun only relatively recently to explore and analyse this technique. After briefly discussing the current critical discussion of trans-diegetic music and explicating patterns of its use in Ashby’s career, this paper explores an extended display of the strategy in the film Coming Home (1978). By interrogating its use as both narrative device and formal convention in this instance, the paper attempts both to understand trans-diegesis as a key component of Ashby’s filmmaking style and also to forge ahead in expanding the discussion of trans-diegesis within film studies.
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Igwe, Onyeka, and JD Stokely. "Hiraeth, or queering time in archives otherwise." Alphaville: Journal of Film and Screen Media, no. 16 (January 30, 2019): 9–23. http://dx.doi.org/10.33178/alpha.16.01.
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Archives are the physical manifestations of our collective understanding of history, a way of proving and so legitimising the existence of cultures, practices, and peoples. However, for queer and trans people of colour (QTPOC), entrance into the archive is not easily permitted; the truths of their lives have been, and are presently, excluded, claimed as contingent and/or rendered “folk”—lesser forms of knowledge. “Hiraeth” is a Welsh word that is difficult to translate into English. It speaks of a longing or homesickness for a place that is no longer, or never was. For QTPOC, the archive is this, a hiraeth space. We use “hiraeth” to describe the liminal space in which experiences of home, media practices, and a relationship to the archive can exist. As two Black queer artists who in their work have been exploring ways to implode the archive, in this article we look at how our practices can expand what the archive holds and further provide a space to render the untranslatable, the im/possible, as archive material. It is a strategy of both redefinition and defiance.
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Pos, Robert. "A Developmental Theory of Personality Producing Two Time Orientations." KronoScope 6, no. 1 (2006): 83–104. http://dx.doi.org/10.1163/156852406777505327.
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AbstractThis paper describes a theory of genetically determined personality development, including the development of two mutually exclusive time orientations: alphas preferentially relate to their present, often being inattentive to their past and future; betas preferentially relate to their future and past, and tend to be inattentive to their present. These time orientations or perspectives derive from two types of autobiographic memory materializing around age 6, which cause two types of personality. For example, the theory views alphas as extroverted and betas as introverted although there are significant differences between Jung's view of these traits and the theory's definitions. Beginning at birth, the amalgam of inborn motivational contexts induces a context-specific partitioning of reality. This is left intact when an alpha child's autobiographic memory, which is free of trans-contextual sequencing of memories, becomes active and the child's identity becomes therefore multi-focal (situational), as represented by Jung's personality model. By contrast, a beta child spontaneously produces a trans-contextual sequence of memories. The youngster's partitioned reality fuses, leading to a singular, monofocal identity, as represented by Freud's personality model. Self-reflection in adolescence makes both implicit identities self-conscious. The underlying genes possibly belong to the X-chromosome, the alpha gene being dominant and the beta gene recessive.
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Wu, Q., M. I. Dawson, Y. Zheng, P. D. Hobbs, A. Agadir, L. Jong, Y. Li, R. Liu, B. Lin, and X. K. Zhang. "Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids." Molecular and Cellular Biology 17, no. 11 (November 1997): 6598–608. http://dx.doi.org/10.1128/mcb.17.11.6598.
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All-trans-retinoic acid (trans-RA) and other retinoids exert anticancer effects through two types of retinoid receptors, the RA receptors (RARs) and retinoid X receptors (RXRs). Previous studies demonstrated that the growth-inhibitory effects of trans-RA and related retinoids are impaired in certain estrogen-independent breast cancer cell lines due to their lower levels of RAR alpha and RARbeta. In this study, we evaluated several synthetic retinoids for their ability to induce growth inhibition and apoptosis in both trans-RA-sensitive and trans-RA-resistant breast cancer cell lines. Our results demonstrate that RXR-selective retinoids, particularly in combination with RAR-selective retinoids, could significantly induce RARbeta and inhibit the growth and induce the apoptosis of trans-RA-resistant, RAR alpha-deficient MDA-MB-231 cells but had low activity against trans-RA-sensitive ZR-75-1 cells that express high levels of RAR alpha. Using gel retardation and transient transfection assays, we found that the effects of RXR-selective retinoids on MDA-MB-231 cells were most likely mediated by RXR-nur77 heterodimers that bound to the RA response element in the RARbeta promoter and activated the RARbeta promoter in response to RXR-selective retinoids. In contrast, growth inhibition by RAR-selective retinoids in trans-RA-sensitive, RAR alpha-expressing cells most probably occurred through RXR-RAR alpha heterodimers that also bound to and activated the RARbeta promoter. In MDA-MB-231 clones stably expressing RAR alpha, both RARbeta induction and growth inhibition by RXR-selective retinoids were suppressed, while the effects of RAR-selective retinoids were enhanced. Together, our results demonstrate that activation of RXR can inhibit the growth of trans-RA-resistant MDA-MB-231 breast cancer cells and suggest that low cellular RAR alpha may regulate the signaling switch from RAR-mediated to RXR-mediated growth inhibition in breast cancer cells.
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Atweh, G. F., J. M. Liu, H. E. Brickner, and X. X. Zhu. "A silencer element from the alpha-globin gene inhibits expression of beta-like genes." Molecular and Cellular Biology 8, no. 11 (November 1988): 5047–51. http://dx.doi.org/10.1128/mcb.8.11.5047-5051.1988.
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We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.
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Atweh, G. F., J. M. Liu, H. E. Brickner, and X. X. Zhu. "A silencer element from the alpha-globin gene inhibits expression of beta-like genes." Molecular and Cellular Biology 8, no. 11 (November 1988): 5047–51. http://dx.doi.org/10.1128/mcb.8.11.5047.
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We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.
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Knight, K. L., M. Kingzette, M. A. Crane, and S. K. Zhai. "Transchromosomally derived Ig heavy chains." Journal of Immunology 155, no. 2 (July 15, 1995): 684–91. http://dx.doi.org/10.4049/jimmunol.155.2.684.
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Abstract During an immune response, activated B cells undergo isotype switching and begin to express isotypes other than IgM and IgD. Isotype switching occurs when downstream C gamma, C alpha, or C epsilon genes are rearranged into the S mu chromosomal region, resulting in the deletion of the region in between. These rearrangements usually occur in cis, i.e., intrachromosomally. In previous studies, we analyzed allotypic specificities of rabbit secretory IgA and identified a substantial number of IgA heavy chains with VH and C alpha allotypes that were encoded by VH and C alpha genes in trans. In those studies, however, we could not determine whether the trans association of VH and C alpha occurred during VDJ gene rearrangement or during isotype switching. Here, we cloned rabbit cDNA which encodes these trans IgA heavy chains and determined the chromosomal origin of the VH, JH, and C alpha regions. To determine whether the trans association occurred during VDJ gene rearrangement, we analyzed the nucleotide polymorphism of the JH region and the VH allotype encoded by the cDNA. We found that the VH and JH genes used in the VDJ gene rearrangements were from the same chromosome, indicating that the VH, D, and JH gene rearrangements occurred in cis. Furthermore, we analyzed the DNA polymorphisms of JH and C alpha and showed that the VDJ and C alpha genes encoding the trans IgA molecules were derived from different parental chromosomes. We suggest that the trans association occurred during isotype switching. This study shows that VH and CH can associate transchromosomally as part of a normal immune response.
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Worley, D. S., J. M. Pisano, E. D. Choi, L. Walus, C. A. Hession, R. L. Cate, M. Sanicola, and S. J. Birren. "Developmental regulation of GDNF response and receptor expression in the enteric nervous system." Development 127, no. 20 (October 15, 2000): 4383–93. http://dx.doi.org/10.1242/dev.127.20.4383.
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The development of the enteric nervous system is dependent upon the actions of glial cell line-derived neurotrophic factor (GDNF) on neural crest-derived precursor cells in the embryonic gut. GDNF treatment of cultured enteric precursor cells leads to an increase in the number of neurons that develop and/or survive. Here we demonstrate that, although GDNF promoted an increase in neuron number at all embryonic ages examined, there was a developmental shift from a mitogenic to a trophic response by the developing enteric neurons. The timing of this shift corresponded to developmental changes in gut expression of GFR alpha-1, a co-receptor in the GDNF-Ret signaling complex. GFR alpha-1 was broadly expressed in the gut at early developmental stages, at which times soluble GFR alpha-1 was released into the medium by cultured gut cells. At later times, GFR alpha-1 became restricted to neural crest-derived cells. GFR alpha-1 could participate in GDNF signaling when expressed in cis on the surface of enteric precursor cells, or as a soluble protein. The GDNF-mediated response was greater when cell surface, compared with soluble, GFR alpha-1 was present, with the maximal response seen the presence of both cis and trans forms of GFR alpha-1. In addition to contributing to GDNF signaling, cell-surface GFR alpha-1 modulated the specificity of interactions between GDNF and soluble GFR alphas. These experiments demonstrate that complex, developmentally regulated, signaling interactions contribute to the GDNF-dependent development of enteric neurons.
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Jameson, J. L., P. J. Deutsch, G. D. Gallagher, R. C. Jaffe, and J. F. Habener. "trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene." Molecular and Cellular Biology 7, no. 9 (September 1987): 3032–40. http://dx.doi.org/10.1128/mcb.7.9.3032-3040.1987.
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The alpha subunit of the placental hormone chorionic gonadotropin is regulated by cyclic AMP (cAMP) at the transcriptional level. A cAMP-responsive fusion gene (alpha-CAT) containing 1.5 kilobases of the alpha gene 5'-flanking sequence linked to the chloramphenicol acetyltransferase (CAT) gene was used as a transcriptional reporter in competition assays in transfected JEG-3 choriocarcinoma cells. Expression of the alpha-CAT fusion gene increased linearly with increasing amounts of transfected plasmid and was maximal at the same amount of alpha-CAT DNA (2 micrograms) with or without cAMP treatment. Various amounts of different competitor DNA sequences were cotransfected with the alpha-CAT reporter plasmid to examine the interactions of intracellular trans-acting factors with the regulatory elements of the alpha gene promoter. An 800-base-pair fragment of alpha gene 5'-flanking sequence inhibited both basal and cAMP-stimulated transcription of the alpha-CAT reporter plasmid in a dose-dependent manner, indicative of interactions with one or more trans-acting factors that activate alpha gene expression. The alpha gene sequences that interact with intracellular regulatory factors were defined by using several discrete regions of the 5'-flanking sequence as competitors for alpha-CAT expression. A proximal promoter sequence (-99 to +44) containing the CCAAT box, TATA box, and transcriptional initiation site was a relatively ineffective competitor of alpha-CAT transcription. In contrast, an upstream sequence between -236 and -100 was an effective competitor for transcriptional activators of alpha-CAT expression. Competition for alpha-CAT expression by this regulatory sequence did not require cis interactions with downstream promoter elements and was equally effective with or without cAMP treatment. An 18-base-pair repeated sequence within this region of the alpha gene (-146 to -111) greatly enhanced both basal gene expression and cAMP responsivity and also competed for limiting cellular transcription factors. These findings suggest that JEG-3 cells contain trans-acting factors that interact with a cAMP response element to activate alpha gene transcription. The chorionic gonadotropin beta gene 5'-flanking sequence also competed for alpha-CAT expression, suggesting that a common trans-acting factor is shared by the regulatory sequences of the alpha and beta genes.
Dissertations / Theses on the topic "Alpha Transu"
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TERNER, MATHIEU. "Innovative materials for high temperature structural applications: 3rd Generation γ-TiAl fabricated by Electron Beam Melting." Doctoral thesis, Politecnico di Torino, 2014. http://hdl.handle.net/11583/2527509.
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In the aeronautics industry, the propulsion systems stand among the most advanced and critical components. Over the last 50 years, gas turbine aeroengines were subjected to intensive research to increase efficiency and reduce weight, noise and harmful emissions. Together with design optimization, breakthrough in materials science for structural applications triggered the development of the most advanced gas turbine engines. For low temperatures, basically ahead of the combustion section, lightweight Ti alloys are preferred for their good mechanical properties. For high temperatures instead, Ni-based superalloys exhibit outstanding properties up to very high temperatures despite a rather high material’s density.
Research have focused on enhancing to the maximum the potential of materials in gas turbine engines. According to the application, the components experience various mechanical and environmental constraints. Special designs, manufacturing process, material compositions and protective coatings have been developed to push the limits of advanced materials. Nowadays, the attention is focused on innovative materials to replace the existing Ti and Ni based alloys leading to substantial benefits. Light weight composite materials in particular were found very attractive to replace some components’ Ti alloys. At higher temperatures, it is of great interest to replace Ni-based superalloys by materials with lower density and/or higher temperatures applications, which in turn would lead to substantial weight reduction and increase efficiency.
At the highest temperatures range, in particular in the combustion chamber and high pressure turbine sections, ceramic based materials offer promising balance of properties. Research are dedicated to overcome the drawbacks of ceramics for such structural applications, and in particular their brittle fracture behavior, by addition of reinforcing fibers. At lower temperatures range, TiAl based intermetallics emerged as very promising materials at half the density of Ni-based superalloys. Significant weight reduction could be achieved by the introduction of TiAl based alloys for rotating components of the compressor and low pressure turbine. 2nd generation γ-TiAl alloys were lately introduced in GE’s GEnx and CFM’s LEAP engines.
The present work concerns the fabrication by the additive manufacturing technique Electron Beam Melting of 3rd generation γ-TiAl alloys for high temperatures application in gas turbine aeroengines. EBM, building parts layer by layer according to CAD, offers many advantages compared to other manufacturing processes like casting and forging. Reported by Avio, 2nd generation γ-TiAl alloys have been successfully fabricated by EBM. To increase the material’s potential, the production of 3rd generation γ-TiAl alloys Ti-(45-46)Al-2Cr-8Nb was therefore studied. The optimization of the EBM parameters led to high homogeneity and very low post-processing residual porosity ≤ 1%. The fine equiaxed microstructure after EBM could be tailored towards the desired mechanical properties by simple heat treatment, from equiaxed to duplex to fully lamellar. In particular, a duplex microstructure composed by about 80 % lamellar grains pinned at grain boundaries by fine equiaxed grains was obtained after heat treatment slightly over the α transus temperature.
The study showed that addition of a higher amount of Nb significantly increased the oxidation resistance of the material, thus increasing the application temperature range of these γ-TiAl alloys.
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Romano, Dina Lynn. "Characterization of alpha-cyclodextrin inclusion complexes with trans-cinnamic acid in an acid-based beverage system." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/42111.
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In response to a need for a natural antimicrobial to replace sodium benzoate, cinnamic acid was chosen. Due to cinnamic acidâ s solubility issues, α-cyclodextrin was used as a host molecule to form an inclusion complex with the cinnamic acid molecule. The cinnamic acid: α-cyclodextrin inclusion complex was then characterized using phase solubility analysis, proton nuclear magnetic resonance (H-NMR), and solid inclusion. Phase solubility analysis verified the maximum amount of cinnamic acid that α-cyclodextrin was able to host. H-NMR was used to determine the complex association constant, determine the chemical shifts of available protons, and yield a stoichiometry for the complex. The solid inclusion complex allowed for a physical formation of the complex, yielding further information in support of the complex stoichiometry. Microbiological tests were also performed to quantify the antimicrobial abilities of the complex, the guest, and the host against the yeast Saccharomyces cerevisiae and mold Paecilomyces variotii.
Results indicated that approximately 990.29 ppm in aqueous solution was the maximum amount of cinnamic acid in the complex. The 2:1 stoichiometry yields an association constant of 21.7 M-1. Results also indicated that the cinnamic acid readily conformed to fit within the α-cyclodextrin host molecule, which remained a rigid structure. An 8.9% weight to weight of cinnamic acid was calculated for the solid inclusion again reinforcing a 2:1 stoichiometry. Microbiological studies showed little to no inhibition power by the complex at varying concentrations against S. cerevisiae and P. variotii. Free cinnamic acid showed greater antimicrobial activity compared with free α-cyclodextrin and the complex.Master of Science in Life Sciences
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Moua, Pachai Susan. "The effects of cis- and trans-acting mutations on recombinant protein secretion in Pichia pastoris." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/185.
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Pichia pastoris is a methylotrophic yeast that has been used in both research and industrial settings for recombinant protein expression due to the ease of genetically modifying its genome, its ability to grow to large densities in inexpensive media, and its capability to perform posttranslational modifications. Multiple tools such as the cis -acting factors MATα secretion signal and MBP fusion partners, and trans-acting modifications such as the bgs mutants have increased heterologous protein secretion. Although these techniques have already been used, their effects on the protein secretory pathway have yet to be elucidated. In this study, fluorescence microscopy was used to compare the localization of proteins expressed with the mutated MATα with the deletion of amino acids 57-70 to the wild type MATα secretion signal. Additional fluorescence microscopy was completed to visualize the localization of MBP-EGFP and EGFP-MBP fusion proteins and their spatial relativity to organelle markers. EGFP-MBP was used to further distinguish the properties of multiple bgs mutants. Additionally, secreted lipase activity levels were evaluated in bgs13 strains expressing either the wild type or the mutated MAT&agr; signal peptide. The results indicated that regardless of their differences, the MATα secretion signals and bgs mutants transported their cargo proteins through similar pathways within the cells. The results of the MBP fusion proteins suggest that the arrangement of MBP significantly influences protein secretion and localization. Lastly, the bgs13 mutant with MATα secretion signals demonstrated that lipase activity increased additively when cis- and trans -acting mutations were combined. Ultimately, these results can provide better understanding of each modified factor and the protein sorting pathway, leading to potential techniques that optimize protein secretion in P. pastoris .
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Haase, Malte. "Untersuchungen zum Mechanismus der Kondensation zwischen Trans-4-n-Propyl-L-Prolin und [alpha]-Methylthiolincosaminid [Alpha-Methylthiolincosaminid] der Lincomycin-A-Biosynthese aus Streptomyces lincolnensis NRRL 2936." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=971614377.
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Diaz, Gamboa Oscar Wilfredo. "Microencapsulação de tocoferóis em matrizes lipídicas advindas de gorduras low trans interesterificadas quimicamente." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254680.
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Orientador: Lireny Aparecida Guaraldo GonçalvesTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-19T08:12:03Z (GMT). No. of bitstreams: 1 DiazGamboa_OscarWilfredo_D.pdf: 1876345 bytes, checksum: 56e9f8f4f7650f56a9f3dd8d60c68957 (MD5) Previous issue date: 2011
Resumo: O presente projeto visou estabelecer condições ideais de obtenção de um produto que poderá ser disponibolizado para comercialização no Brasil tendo como foco a encapsulação para aplicação na área alimentícia. Tocoferóis são antioxidantes naturais que podem ser utilizados para enriquecimento de alimentos. Contudo há a necessidade de proteção desse agente ativo por métodos especiais como a microencapsulação. No presente estudo foram desenvolvidos sistemas compostos por micropartículas obtidas por ¿spray chilling" utilizando lipídios interesterificados sem isômeros trans com óleo de soja totalmente hidrogenado na relação de 70:30% m/m respectivamente, com ponto de fusão na faixa de 40-65 °C para formação das matrizes. Alfa-tocoferol foi utilizado como principio ativo a ser encapsulado. Para a obtenção das micropartículas matrizes lipídicas foram fundidas e mantidas em banho à temperatura de 65 °C . O a-tocoferol foi adicionado nas misturas lipídicas que em seguida foram homogeinizados em ultraturrax. As soluções foram pulverizadas em atomizador duplo fluido aquecido também a 65 °C e pressão de ar de 0,25 MPa, com a a tomização efetuada dentro de uma câmara resfriada a 10 °C. Foi realizado um p lanejamento DCCR (Delineamento Central Rotacional) com 2 variáveis independentes: a velocidade de homogeneização (3000 a 11000 rpm) e a concentração de tocoferol (5-25 g/100g). A quantificação do princípio ativo encapsulado foi realizada utilizando técnica isocrática de cromatografia líquida de alta eficiência (CLAE). Os tratamentos foram caracterizados em relação à eficiência de encapsulação, morfologia, tamanho médio, estabilidade e liberação do princípio ativo. Para o estudo da estabilidade os tratamentos foram submetidos à estocagem por 180 dias em três diferentes temperaturas (ambiente 25°C ±5 °C, em estufa 22 °C e freezer a -18°C). Medidas de difração de raios-X (0 , 60, 120, 180 dias) e medidas calorimétricas (tempo zero) foram efetuadas. Foi realizada a incorporação das micropartículas em um produto comercial (Iogurte), que foi avaliado sensorialmente. De forma geral, as partículas lipídicas obtidas neste trabalho apresentaram bons resultados quanto à eficiência de encapsulação e apresentando forma esférica, com paredes contínuas, porém rugosas. Os termogramas, obtidos por calorimetria diferencial de varredura (DSC), em tempo zero, não apresentaram diferenças entre os ensaios. Os difratogramas foram muito semelhantes entre os tratamentos e constatou-se a presença de 3 picos principais que parecem estar associados à forma polimórfica ß. As micropartículas de liberação apresentaram boa capacidade de controle da liberação do composto ativo, mostrando-se potenciais para o uso futuro na indústria de alimentos. Finalmente os resultados da análise sensorial de aceitação não foram estatisticamente significativos para os atributos avaliados
Abstract: This project aimed to establish optimal conditions for obtaining a product that will be commercially available in Brazil, focusing on encapsulation for use in the food industry. Tocopherols are natural antioxidants that can be used for food enrichment.However, there is the need for protection of active agent by special methods, such as microencapsulation. The present study developed systems composed of microparticles obtained by "spray chilling" using an interesterified fat with no trans isomers with fully hydrogenated soybean oil in the ratio of 70:30% w/w respectively, with a melting point in the range of 40-65°C for the formation of matrices to encapsulate a-tocopherol as active principle.To obtain small particles a lipid matrices were melted in a water bath at a temperature of 65°C. The a-tocopherol was added to the lipid mixtures and then homogenized in Ultra Turrax for 5 min.The solutions were sprayed in double-fluid atomizer also heated to 65°C and air pressure of 0.25 MPa, the atomization performed inside a chamber cooled to 10°C. Were conducted a CCR design (Central Compo site Rotational Design) with two independent variables: the speed of homogenization (3000 to 11000 rpm) and the concentration of tocopherol (5-25 g/100 g).The quantification of the active ingredient encapsulated was performed using isocratic HPLC technique. The treatments were characterized with respect to encapsulation efficiency, morphology, average size and stability of the microparticles and release of active ingredient.For the stability study treatments were subjected to storage for 180 days at three different temperatures (ambient 25°C ± 5°C , 22°C in an oven and freezer -18°C).Since x-rays diffraction measurements (0, 60, 120, 180 days) and calorimetric measurements (time zero) were made. Were performed the incorporation of the microparticles in a commercial product (yogurt), which was evaluated using the sensory evaluation.In general, the lipid particles studied in this work showed good results in terms of encapsulation efficiency showing spherical shape, with solid rough walls. The thermograms obtained by DSC at time zero did not differ between trials.The XRD patterns were very similar among treatments and found the presence of three major peaks that are associated with the polymorphic form ß. The microparticles showed good ability to control the release of the active principle, showing potential for future use in the food industry. Finally the results of an smooth sensory acceptance indicated that the tested samples did not differ statistically from the standard sample for evaluated attributes
Doutorado
Tecnologia de Alimentos
Doutor em Tecnologia de Alimentos
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Beyer, Christine. "Der Einfluss von all-trans-Retinol, 13-cis-Retinsäure, Methanol und TSH unter verschiedenen Kulturbedingungen auf den 125I-Stoffwechsel von kultivierten Thyreozyten und deren RAR alpha- und RXR alpha- Rezeptoren." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11312764.
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Ririe, Seth S. "Structure and function of the polypyrimidine region of the rat [alpha]1 (I) procollagen gene promoter." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9998517.
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Ritter, Linda Marie. "Promoter Studies of The Human MIP-1(alpha) Gene and Characterization of Two Novel trans-Acting Factors: MNP-1 and MNP-2 /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351058656.
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Farrow, Michael John. "The effect of androstenediol on gene expression and NF-κB activation in vitro." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1187109346.
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Terry, Jennifer L. "The characterization of TRUSS : a novel scaffolding protein in tumor necrosis factor-[alpha] receptor-1 signaling /." Connect to full text via ProQuest. IP filtered, 2005.
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Thesis (Ph.D. in Immunology) -- University of Colorado, 2005.Typescript. Includes bibliographical references (leaves 190-212). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
Books on the topic "Alpha Transu"
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Offshore operations post Piper Alpha: London, 6 - 8 February 1991 (Trans IMarE). Published for Institute of Marine Engineers by Marine Management (Holdings) Ltd, 1991.
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Fancypants, Gaylord. The T-Girl Delicately Dances From Alpha to Alpha in a Line That Zigzags Like Show-Worthy Shafts: An MM Trans/Rough Trade Novella. Independently Published, 2019.
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Lorent, Kristin. Expression of the Alpha-2-Macroglobulin Receptor System and the Amyloid Precursor Protein Family in Embryos and in Adult Brain of Wild Type and transg: Enic Mice (Acta Biomedica Lovaniensia , No 148). Coronet Books Inc, 1997.
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Devine, Michelle F., and Sean J. Pittock. "Constipation and Syncope." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin, 143–45. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0046.
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A 43-year-old woman sought care for severe constipation associated with syncopal episodes. Her constipation alternated with explosive diarrhea. Chronic left-sided abdominal pain and severe bloating developed after eating. She was diagnosed with irritable bowel syndrome. After the initial onset of symptoms, nausea, bloating, and intractable vomiting developed. Symptoms were exacerbated by food and were partially relieved with vomiting. She had multiple episodes of bilious, undigested emesis per day. Trials of antiemetics and motility agents provided no substantial relief. She adopted a liquid diet, avoided solid foods, and eventually had a gastrostomy tube placed. She lost at least 15.9 kg over 2 years. Review of systems was significant for generalized fatigue and a burning sensation in her hands and feet. Her medical history was pertinent for Graves disease previously treated with remote thyroid radioablation, and she was now taking thyroid hormone replacement therapy. Neurologic examination findings were normal except for unreactive pupillary light reflexes. A gastrointestinal tract transit study showed persistently delayed colonic transit with mildly delayed gastric emptying. Autonomic reflex screening showed diffuse postganglionic sympathetic sudomotor, severe cardiovagal, and severe cardiovascular adrenergic impairment. Thermoregulatory sweat testing showed diffuse anhidrosis. Creatinine value was mildly increased. The serum was strongly positive for ganglionic (alpha 3) acetylcholine receptor-immunoglobulin G. The findings strongly suggested an autonomic autoimmune polyganglionopathy, with autoimmune gastrointestinal dysmotility as the predominant phenotype. She received intravenous immunoglobulin. She had complete resolution of her previous constipation, nausea, and vomiting. She regained 22.7 kg. Her gastrostomy tube was removed. Repeated gastrointestinal tract transit studies approached normal findings. Repeated autonomic testing and thermoregulatory sweat testing showed improvement. Over several months, the intravenous immunoglobulin dose was tapered. The patient remained asymptomatic for 8 years on long-term immunosuppression with azathioprine, she had a recurrence of her previous symptoms. Repeated gastrointestinal tract transit studies again showed delayed gastrointestinal tract emptying. Another intravenous immunoglobulin course controlled her symptoms, with normalization of gastrointestinal tract transit studies. Autoimmune gastrointestinal dysmotility can manifest as either hypomotility or hypermotility but most often presents as gastroparesis or pseudo-obstruction. Symptoms include nausea, vomiting, bloating, early satiety, diarrhea, constipation, and involuntary weight loss. It can be idiopathic or paraneoplastic. Risk factors for idiopathic cases include personal or family histories of autoimmunity.
Conference papers on the topic "Alpha Transu"
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"O-023 - ALPHA-PHP; UNA AMENAZA EMERGENTE." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.o023.
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Introducción: Alpha Pyrrolidinohexanofenona (Alpha PHP o Alpha PV7) es una cationa sintética sin uso médico utilizada como droga de abuso. Es un inhibidor de la recaptación de Dopamina, Noradrenalina y Serotonina. El efecto tras el consumo es activación del sistema simpático, euforia y desinhibición. Las distintas vías de administración marcan el tiempo de latencia de aparición de síntomas y la duración e intensidad de los mismos, estando documentado el consumo por vía oral, inhalada o sublingual e intravenoso. Los distintos cuadros clínicos con sintomatología psiquiátrica que puede producir son la intoxicación con alteraciones de la sensopercepción y episodios psicóticos inducidos por Alpha-PHP. En la actualidad el consumo de Alpha-PHP está relacionado epidemiológicamente como el chem-sex y Hombres que tienen sexo con hombres, aunque existe consumo fuera de este ámbito. Objetivos: Exponer las diferencias clínicas y epidemiológicas entre 3 casos clínicos que presentaron sintomatología psicótica en relación con consumo de Alpha-PHP. Entre las variables se encuentran la vía de consumo, el patrón, el contexto epidemiológico, la sintomatología desarrollada, el tratamiento y la evolución. Métodos: Análisis de la variabilidad clínica mediante la exploración psicopatológica Evaluación de la sintomatología y la respuesta al tratamiento mediante escalas de valoración clínica (PANSS) Valoración del tratamiento administrado en fase aguda y tras el alta hospitalaria. Resultados: Se observaron diferencias en la respuesta al tratamiento que se evaluaron mediante las escalas previstas para el estudio. El consumo de alpha PHP tuvo repercusión negativa en la calidad de vida de los tres pacientes, aunque de distinto modo. Conclusión: El Alpha PHP es una sustancia con alto impacto en la calidad de vida y motivo de estudio tanto por la facilidad de adquirir la sustancia, el efecto en quien la consume y por los patrones de consumo con que se relaciona y la relación con otras patologías infecciosas.
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Choi, Young Eun, Junkyu Song, Yong Hwa Jo, Hyun Mi Park, and Kyung-Sik Yoon. "Abstract 2079: Estrogen receptor alpha expression with miR-206 trans-acting regulation roles in breast cancer cell lines." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2079.
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"PV-067 - REAGUDIZACIÓN PSICÓTICA ASOCIADA AL CONSUMO DE ALPHA-PYRROLIDINOPENTIOPHENONE: A PROPÓSITO DE UN CASO." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv067.
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Objetivos: La alfa-pirrolidinovalerofenona (α-PVP), comúnmente conocida como "flakka" o “sales de baño”, es un psicoestimulante sintético con una estructura química relacionada con la catinona, que se usa con fines recreativos por su potencial eufórico. El mecanismo de acción se parece al de la anfetamina al inhibir la recaptación de dopamina y norepinefrina. Debido a la excesiva activación simpática, se ha reportado la aparición de delirios, psicosis paranoide, agitación extrema (delirio agitado) y otros estados mentales alterados. El objetivo de este trabajo es presentar un caso clínico en el que se muestran los efectos que puede causar el consumo de α-PVP en una persona con Trastorno esquizoafectivo. Material y métodos: Revisión no sistemática mediante búsqueda bibliográfica en las principales bases de datos, así como el estudio del caso. Resultados y conclusiones: Varón de 33 años, en seguimiento por Salud Mental desde hace 5 años, diagnosticado de Trastorno esquizoafectivo, en tratamiento con paliperidona inyectable. Como antecedentes médicos destaca infección por VIH con buen cumplimiento de TAR. Ingresa en UHP por presentar descompensación psicótica con alteraciones sensoperceptivas de contenido somático e ideación delirante paranoide en el contexto de consumo de alfa-PVP. Tras ajuste de tratamiento y abstinencia de tóxicos, cede la sintomatología. Al alta el paciente es remitido a la UDH y UCA con el objetivo de mejorar conciencia de enfermedad, disminuir/abandonar consumo de alfa-PVP y prevenir nueva recaída e ingreso en UHP. La aparición de sintomatología psicótica tras el consumo de alfa-PVP se ha descrito tanto en pacientes diagnosticados de trastornos mentales como en pacientes sin antecedentes psiquiátricos. La investigación debe centrarse en el estudio de los efectos de dicha sustancia a corto y largo plazo así como en el desarrollo de métodos analíticos para la identificación rápida en el servicio de urgencias.
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Wei, Na, Enada Archibold, Grace Jairo, and Heather Kuiper. "Development of a method for separation of geometric isomers of alpha-linolenic acid in human plasma by silver Ion HPLC and GC-NCI-MS." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fvyw5862.
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Alpha-linolenic acid (ALA), an omega-3 fatty acid essential for humans, must be supplied by diet, mainly from plants. It's a precursor of omega-3 long-chain fatty acids, eicosapentaenoic and docosahexaenoic acids which are essential for human cardiovascular health. ALA consumption may also reduce the risk of heart disease. The geometric isomers of ALA in humans are derived from consumption of industrially produced partially hydrogenated and deodorized vegetable oils. The presence of trans-isomers of ALA in humans may affect the levels of regular ALA, potentially impacting the beneficial effects of ALA. Some studies have reported geometric isomers of ALA in human milk and serum but demonstrate incomplete chromatographic separation. The objective of this work is to develop a method to separate geometric isomers of ALA in human plasma using silver ion high-performance liquid chromatography (Ag-HPLC) and detect them using gas chromatography-negative chemical ionization-mass spectrometry (GC-NCI-MS). Sample preparation involves acidic and alkaline hydrolysis of samples, followed by extraction of free fatty acids with hexane. Ag-HPLC is then employed for isomer separation, HPLC fractions containing each isomer are collected, and finally the samples are analyzed by GC-NCI-MS. Preliminary data shows all eight geometric isomers of ALA (n-3t6t9t, n-3t6t9c, n-3c6t9t, n-3t6c9t, n-3t6c9c, n-3c6t9c, n-3c6c9t, and n-3c6c9c) in plasma can be separated using this approach. Ag-HPLC separation of ALA isomers in human plasma resulted in the same elution times as the isomers in a standard mixture. The identities of the isomers were confirmed by comparing their retention times and mass-to-charge ratios with those of ALA isomer standards via GC-NCI-MS. This approach can potentially be used to investigate the distribution of ALA geometric isomers in human plasma. The full resolution of ALA geometric isomers can ensure accurate identification of these isomers in human plasma, which may aid in understanding their impact on human health.
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Berardi, Damian E., Maria I. Diaz Bessone, Carolina Flumian, Stefano M. Cirigliano, Elisa D. Bal de Kier Joffe, Alejandro J. Urtreger, and Laura B. Todaro. "Abstract 209: Pharmacological inhibition of protein kinase C alpha (PKCα) and all trans retinoic acid (ATRA) synergize to inhibit the proliferation, migration and cancer stem-like properties of a triple-negative mammary cancer model." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-209.
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Nour, Said I., and Mohsen A. Issa. "High Speed Rail Short Bridge-Track-Train Interaction Based on the Decoupled Equations of Motion in the Finite Element Domain." In 2016 Joint Rail Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/jrc2016-5785.
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The interaction between the train, track, and bridge was considered as an interaction between two decoupled subsystems. A first subsystem consisted of the train vehicle simulated as a four-wheelset mass-spring-damper system having two layers of suspensions and ten degrees of freedom. A second subsystem consisted of the track-bridge system assumed to be a top rail beam and a bottom bridge beam coupled by continuous springs and dampers representing the elastic properties of the trackbed smeared over the spacing of the railway ties. The bridge supports were assumed to be rigid or flexible. The equations of motion of a finite element form were derived for each subsystem independently by means of the Newton’s second law. The dynamic interaction between the moving vehicle of the first subsystem and the stationary underlying track-bridge structure of the second subsystem was established by means of a no-separation constraint equation in the contact points between the wheels and the rails. The proposed two-dimensional analysis was intended to accurately describe the vertical behavior of short span bridges subjected to high-frequency excitations due to the passage of high speed trains; therefore, shear deformations, rotational inertia effects, and consistent mass matrices were adopted in the mathematical model. Numerical solutions of the decoupled equations of motion for both subsystems were obtained with the step-by-step direct integration in the time domain using HHT alpha method with a special scheme in the contact interface. The solution accuracy of the proposed method was validated against responses obtained from a semi-analytical method of a train car travelling over a simply supported bridge. The practical engineering application was demonstrated with a case study investigating effects of key parameters in the behavior of a ballasted short span railway bridge. Compared with the moving force model, results showed that for bridges with rigid supports both the vehicle interaction and trackbed produce lower peak responses at resonance speeds with the latter being more significant. However an increase in support flexibility had a greater impact across all speeds in increasing the bridge responses.
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Nawroth, Peter P., Jerry Brett, Susan Steinberg, Charles T. Esmon, and David M. Stern. "ENDOTHELIUM AND PROTEIN S: SYNTHESIS, RELEASE AND REGULATION OF ANTICOAGULANT ACTIVITY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642962.
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The protein C-protein S pathway is closely linked to the vessel wall. In terms of protein C, endothelium has been shown to provide the receptor thrombomodulin, which promotes thrombin-mediated formation of activated protein C. Optimal anticoagulant function of activated protein C requires protein S and a cellular surface. Recent studies have indicated that endothelium can facilitate assembly of the activated protein C-protein S complex and that bovine endothelium expresses specific binding site(s) for protein S which promote its anticoagulant function. Expression of protein S binding sites is subject to down-regulation by Tumor Necrosis Factor (TNF) . Exposure of cultured bovine endothelium to TNF results in decreased 125I-protein s binding and attenuated rates of Factor Va inactivation after 2 hrs followed by negligible 125I-protein S binding and Factor Va inactivation by 10 hrs. These changes persist for over 48 hrs, in contrast to the more transient rise in endothelial cell tissue factor induced by TNF which returns to baseline by 24 hrs.In addition to providing binding sites for protein S, endothelium constitutively synthesizes and releases this vitamin K-dependent anticoagulant cofactor. Release of protein S is blocked by addition of warfarin, indicating that y-carboxylation facilitates the release of intracellular protein S. Morphologic studies, at the level of electron microscope, have shown protein S antigen to be present in cisternae of rough endoplasmic reticulum, the trans face of the golgi and a population of intracellular vesicles which appear to be distributed at the cellular periphery. By immunofluorescence, the distribution of protein S is distinct from that of von Willebrand Factor. The intracellular vesicles containing protein S constitute a storage pool potentially available for rapid release. Treatment of endothelium with norepinephrine results in release of protein S over the next 20 min. Release is half-maximal at a norepinephrine concentration of about 0.1 uM and is not observed with the biologically inactive entantiomer (+) norepinephrine. Norepinephrine-induced release of intracellular protein S can be blocked by prazosine (10-7 7 M), but not by propranolol (10-6 M) or yohimbine (10-5 M). These data are consistent with release of protein S being a receptor-mediated process dependent on an endothelial cell alpha 1 adrenergic receptor. Blockade of norepinephrine-induced release of protein S by pertussis toxin treatment of endothelium further defines the intracellular pathway of protein S and implicates regulatory G proteins in the stimulus-response coupling. Electron microscopic studies have shown that following exposure of endothelium to norepinephrine the intracellular vesicles containing protein S undergo exocytosis at the plasma membrane. These data define a new relationship between the autonomic nervous system and the coagulation mechanism.Protein S is clearly an endothelial cell-associated anticoagulant protein. A specific binding site on the endothelial cell surface can regulate its anticoagulant function on the vessel wall. Endothelial cell synthesis and release of protein S defines a new level of participation of endothelium in the protein C-protein S pathway.