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Journal articles on the topic 'Alpha Autoradiography'

Author: Grafiati

Published: 25 May 2024

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1

Takekawa, Shoichi, Yoshihiko Ueda, Yoshihiko Ueda, Yoshihiro Hiramatsu, Hirotsugu Munechika, and Fumio Shishido. "Imaging of Beta-Rays from Tissue Blocks with Thorotrast Deposition by Autoradiography using Fuji Computed Radiography." Jurnal Radiologi Indonesia 1, no. 2 (2015): 58–64. http://dx.doi.org/10.33748/jradidn.v1i2.7.

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Background: Autoradiography of tissue with radioactive substance such as Thorotrast by Fuji Computed Radiography (FCR) has been available. We obtained autoradiographs from Thorotrast-deposited tissue by FCR. However, the nature of radiation from tissue with Thorotrast was not certain, because alpha particles are shielded by the plastic front of the FCR cassette. Therefore, we undertook investigation to clearly explain the nature of radiation from Thorotrast in case of autoradiography.Materials and Methods: Tissue blocks of liver and spleen with Thorotrast deposition were imaged by autoradiogra

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2

Carpentier, J. L., D. Brown, B. Iacopetta, and L. Orci. "Detection of surface-bound ligands by freeze-fracture autoradiography." Journal of Cell Biology 101, no. 3 (1985): 887–90. http://dx.doi.org/10.1083/jcb.101.3.887.

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This article describes a new freeze-fracture autoradiographic technique for the detection of radioactive ligands associated with the surface of cells in monolayer or suspension culture. Since freeze-fracture replicas are produced in the conventional way, all membrane features normally seen in freeze-fracture are retained, and autoradiographic grains produced by the labeled ligands are seen superimposed on unaltered exoplasmic membrane fracture faces. To assess the feasibility and resolution of this technique, we compared the surface distribution of alpha 2-macroglobulin and cholera toxin, labe

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3

Stumpf, W. E., J. K. Morin, B. W. Ennis, J. E. Zielinski, and R. B. Hochberg. "Utility of [16 alpha-125I] iodoestradiol for autoradiography for the study of cellular and regional distribution of receptors." Journal of Histochemistry & Cytochemistry 35, no. 1 (1987): 87–92. http://dx.doi.org/10.1177/35.1.3794310.

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We demonstrate the utility of [16 alpha-125I]iodoestradiol for thaw-mount autoradiography with 2 micron and 4 micron thick sections of rat and mouse uterus, pituitary, and brain after in vivo administration. Under the conditions of the experiments, short-term autoradiography with exposure times between 3 and 14 days provides optimal cellular resolution, whereas long-term autoradiography with 1-2 months of exposure may be used to obtain topographic-regional surveys of distribution.

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4

Maltier, J. P., I. Petit, and C. Legrand. "Autoradiographic visualization of alpha 1-adrenergic receptors in cervix of early pregnant rat." Journal of Histochemistry & Cytochemistry 37, no. 5 (1989): 703–7. http://dx.doi.org/10.1177/37.5.2539410.

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alpha 1-Adrenergic receptors were identified, characterized, and localized in rat cervix on Day 6 of pregnancy by autoradiography. Autoradiographic study was performed in slide-mounted rat cervix sections using [3H]-prazosin ([3H]-PRAZ) as ligand. Binding was time dependent and specific. Pharmacological study indicated that specific [3H]-PRAZ binding was inhibited with high affinity by prazosin and phenylephrine and low affinity by yohimbine and clonidine. In cervix, the alpha 1-adrenergic receptors were localized mainly to the inner circular layer of the myometrium. Binding to the outer longi

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5

AL Darwish, Ruqaya, Alexander Hugo Staudacher, Eva Bezak, and Michael Paul Brown. "Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector." Computational and Mathematical Methods in Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/612580.

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There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy. These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells. Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector. We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector. Additionally, the sensitivity of the Timepix d

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6

Koseki, C., Y. Hayashi, S. Torikai, M. Furuya, N. Ohnuma, and M. Imai. "Localization of binding sites for alpha-rat atrial natriuretic polypeptide in rat kidney." American Journal of Physiology-Renal Physiology 250, no. 2 (1986): F210—F216. http://dx.doi.org/10.1152/ajprenal.1986.250.2.f210.

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To determine the intrarenal localization of receptors for atrial natriuretic polypeptide (ANP) in the rat, we performed autoradiography and binding assay by using 125I-labeled alpha-rat ANP (alpha-rANP). Autoradiography at the slice and microscopic level in the kidney and binding assay in isolated glomeruli demonstrated that receptors in the renal cortex were distributed mainly in glomeruli. Although dense silver grains were distributed diffusely both in inner medulla and outer stripe of outer medulla, a marked displacement of the grains was observed only in the inner medulla. Autoradiography

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7

Dvorak, A. M., R. A. Monahan-Earley, H. F. Dvorak, and S. J. Galli. "Ultrastructural cytochemical and autoradiographic demonstration of nonspecific esterase(s) in guinea pig basophils." Journal of Histochemistry & Cytochemistry 35, no. 3 (1987): 351–60. http://dx.doi.org/10.1177/35.3.3819377.

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We used ultrastructural autoradiographic and cytochemical methods to localize esterase activities in unstimulated guinea pig basophils and in basophils undergoing degranulation or recovery from degranulation. We used tritium-labeled diisopropylfluorophosphate (DFP) as a probe for serine enzymes and localized this probe by ultrastructural autoradiography to cytoplasmic granules of immature or mature unstimulated basophils, as well as to granules released by degranulating basophils. Ultrastructural cytochemistry using alpha naphthyl acetate (ANA) as substrate localized nonspecific esterase activ

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8

Kalnins, Christopher A. G., Nigel A. Spooner, Michael J. P. Clarke, and David Ottaway. "Alpha particle autoradiography for high spatial resolution mapping of radionuclides." Journal of Environmental Radioactivity 197 (February 2019): 9–15. http://dx.doi.org/10.1016/j.jenvrad.2018.11.008.

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9

Healy, D. P., and D. D. Fanestil. "Localization of atrial natriuretic peptide binding sites within the rat kidney." American Journal of Physiology-Renal Physiology 250, no. 3 (1986): F573—F578. http://dx.doi.org/10.1152/ajprenal.1986.250.3.f573.

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Although synthetic atrial natriuretic peptides (ANP) have potent natriuretic/diuretic properties, the renal mechanisms underlying these effects are not yet clearly defined. To determine the possible sites of action for ANP within the kidney, we have localized 125I-ANP binding sites by in vitro autoradiography. Slices of rat kidney were incubated with 150 pM 125I-ANP [alpha-rat ANP (alpha-rANP), 28 amino acids] alone or in the presence of 10 nM or 1 microM unlabeled ANP. Autoradiography was performed using LKB Ultrofilm or emulsion-coated cover slips together with histochemical/immunohistochemi

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10

Verdurand, Mathieu, Elise Levigoureux, Sophie Lancelot, et al. "Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue." Contrast Media & Molecular Imaging 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/9165458.

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The accumulation of aggregated alpha-synuclein (α-syn) in multiple brain regions is a neuropathological hallmark of synucleinopathies. Multiple system atrophy (MSA) is a synucleinopathy characterized by the predominant cerebral accumulation of aggregated α-syn as cytoplasmic glial inclusions (CGI). A premortem diagnosis tool would improve early diagnosis and help monitoring disease progression and therapeutic efficacy. One Positron Emission Tomography (PET) study suggested [11C]BF-227 as a promising radiotracer for monitoring intracellular α-syn deposition in MSA patients. We sought to confirm

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11

Muntz, K. H., C. Garcia, and H. K. Hagler. "alpha 1-Receptor localization in rat heart and kidney using autoradiography." American Journal of Physiology-Heart and Circulatory Physiology 249, no. 3 (1985): H512—H519. http://dx.doi.org/10.1152/ajpheart.1985.249.3.h512.

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To study the distribution of alpha 1-adrenergic receptors in rat heart, kidney, and skeletal muscle, we used light-microscopic autoradiography of [3H]prazosin. Scintillation spectrometry of frozen sections demonstrated rapid binding, saturability, stereospecificity, and agonist and antagonist binding characteristic of an alpha-receptor. For autoradiography, sections were incubated, processed, and grain density quantified using a computer-based image analyzer. Specific alpha 1-receptor binding was found over cardiac myocytes in the left and right ventricles but not over skeletal muscle. Scatcha

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12

Christensen, E. I., J. Gliemann, and S. K. Moestrup. "Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein." Journal of Histochemistry & Cytochemistry 40, no. 10 (1992): 1481–90. http://dx.doi.org/10.1177/40.10.1382088.

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gp330, a large glycoprotein located in renal proximal tubules, has sequence similarities with the low-density lipoprotein receptor and the alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein. The 40 KD human alpha 2-macroglobulin receptor-associated protein is a newly discovered heparin binding protein homologous to a major rat Heymann nephritis factor and exhibiting high affinity binding to the alpha 2-macroglobulin receptor. The present study shows by ligand blotting, light and electron microscopic autoradiography, and cytochemistry that gp330 located in coated ap

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13

Romero, D. P., and A. E. Dahlberg. "The alpha subunit of initiation factor 2 is phosphorylated in vivo in the yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 6, no. 4 (1986): 1044–49. http://dx.doi.org/10.1128/mcb.6.4.1044-1049.1986.

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The phosphorylation state of the alpha subunit of initiation factor 2 (eIF-2 alpha) in Saccharomyces cerevisiae has been determined by two-dimensional gel electrophoresis and autoradiography of lysates from cultures grown under a variety of conditions. The alpha subunit was maintained in a phosphorylated state during logarithmic growth on fermentable and nonfermentable carbon sources, during starvation for an essential amino acid, during heat shock, during stationary phase, and during sporulation. Only when cells were starved for a carbon source for 2 h in 1 M sorbitol was eIF-2 alpha isolated

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14

Romero, D. P., and A. E. Dahlberg. "The alpha subunit of initiation factor 2 is phosphorylated in vivo in the yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 6, no. 4 (1986): 1044–49. http://dx.doi.org/10.1128/mcb.6.4.1044.

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The phosphorylation state of the alpha subunit of initiation factor 2 (eIF-2 alpha) in Saccharomyces cerevisiae has been determined by two-dimensional gel electrophoresis and autoradiography of lysates from cultures grown under a variety of conditions. The alpha subunit was maintained in a phosphorylated state during logarithmic growth on fermentable and nonfermentable carbon sources, during starvation for an essential amino acid, during heat shock, during stationary phase, and during sporulation. Only when cells were starved for a carbon source for 2 h in 1 M sorbitol was eIF-2 alpha isolated

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15

Zhmodik, C. M., and V. A. Ponomarchuk. "GEOCHEMICAL VIEW ON “INOFFENSIVE” DEPLETED URANIUM." Доклады Российской академии наук. Науки о Земле 513, no. 1 (2023): 153–60. http://dx.doi.org/10.31857/s2686739723601229.

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The interaction of alpha radiation from UO2 micro- and nanoparticles (uraninite) with the substance was visualized using alpha-autoradiography data on A-2 thick-layer nuclear photographic emulsions. The spherical area of action of alpha particles around UO2 micrograins, up to 100 microns in size, is a deeply transformed substance with a high density of radiation defects. The translation of these results on a living organism leads to the conclusion about the specific type of impact of micro- and nanoparticles of depleted uranium, in which prolonged internal irradiation in small doses of the who

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16

SHIBATA, KOJI. "Boron Using in Steel and Autoradiography through Alpha-particle Track Etching." RADIOISOTOPES 46, no. 6 (1997): 413–14. http://dx.doi.org/10.3769/radioisotopes.46.413.

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17

McDonald, P., S. W. Fowler, M. Heyraud, and M. S. Baxter. "Polonium-210 in mussels and its implications for environmental alpha-autoradiography." Journal of Environmental Radioactivity 3, no. 4 (1986): 293–303. http://dx.doi.org/10.1016/0265-931x(86)90004-4.

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18

Martin, W. H., T. K. Tolley, and J. E. Saffitz. "Autoradiographic delineation of skeletal muscle alpha 1-adrenergic receptor distribution." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 5 (1990): H1402—H1408. http://dx.doi.org/10.1152/ajpheart.1990.259.5.h1402.

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We used light microscopic autoradiography to quantify the distribution of alpha 1-adrenergic receptors in vessels and muscle fibers of slow-twitch (type I), fast-twitch (types IIa and IIb), and mixed fiber muscles of the rat hindquarter. Frozen cross sections of soleus, vastus lateralis, and gastrocnemius muscles were incubated under equilibrium binding conditions with 10-200 pM [3H]prazosin with or without 10(-5) M phentolamine. Because of the low concentration of bound radioligand, specific binding could not be detected with scintillation spectrometry in whole tissue sections scraped from sl

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19

Zhao, M., H. K. Hagler, and K. H. Muntz. "Regulation of alpha 1-, beta 1-, and beta 2-adrenergic receptors in rat heart by norepinephrine." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 5 (1996): H1762—H1768. http://dx.doi.org/10.1152/ajpheart.1996.271.5.h1762.

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Previous studies suggest that the desensitization and downregulation of beta 1-adrenergic receptors (beta 1-AR) in the failing heart are the result of the elevated plasma catecholamine levels associated with this disease. To examine norepinephrine (NE)-induced regulation of cardiac adrenergic receptors, rats were infused with l-NE (200 micrograms.kg-1.h-1 for 7 days) or vehicle (0.001 N HCl) by implantation of osmotic minipumps. The technique of coverslip autoradiography was used to quantify alpha 1-adrenergic receptors (alpha 1-AR), beta 1-AR, and beta 2-AR in different tissue compartments of

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20

Brown, J., and A. Czarnecki. "Autoradiographic localization of atrial and brain natriuretic peptide receptors in rat brain." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 1 (1990): R57—R63. http://dx.doi.org/10.1152/ajpregu.1990.258.1.r57.

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Displacement of bound 125I-labeled atrial natriuretic peptide-(1-28) [alpha 125I-ANP-(1-28)] by alpha-ANP-(5-28) and porcine brain natriuretic peptide (BNP) was used to map receptors common to these peptides in rat brain by in vitro autoradiography. alpha-125I-ANP bound reversibly to subfornical organ, area postrema, median preoptic, supraoptic and paraventricular nuclei, and arachnoid mater. Binding at these sites was displaced similarly by 1 microM unlabeled alpha-ANP, alpha-ANP-(5-28), and BNP. Binding dissociation constants in the subfornical organ and arachnoid were 4.40 +/- 1.15 and 3.99

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21

Shriwastwa, B. B., B. Raghunath, and J. K. Ghosh. "Selective alpha autoradiography for monitoring thorium distribution in UO2-ThO2 fuel pellets / Selektive Alpha-Autoradiographie zur Bestimmung der Verteilung von Thorium in UO2-ThO2-Brennstofftabletten." Kerntechnik 57, no. 5 (1992): 283–85. http://dx.doi.org/10.1515/kern-1992-570506.

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22

McCormack, D. G., J. C. Mak, M. O. Coupe, and P. J. Barnes. "Calcitonin gene-related peptide vasodilation of human pulmonary vessels." Journal of Applied Physiology 67, no. 3 (1989): 1265–70. http://dx.doi.org/10.1152/jappl.1989.67.3.1265.

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Human calcitonin gene-related peptide (CGRP) is localized to sensory neurons in pulmonary vessels and is a potent vasodilator. We have characterized the effects of CGRP in human pulmonary vessels and localized the receptors for this peptide by autoradiography. Fresh human lung tissue was obtained from eight patients undergoing surgery and small (200–400 microns ID) pulmonary arteries and veins were dissected free of surrounding connective and pulmonary tissue. Pairs of vessels were studied and in one of each pair the endothelium was left intact and from the other of each pair the endothelium w

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23

ISHIGURE, Nobuhito, Takashi NAKANO, Hiroko ENOMOTO, Akira KOIZUMI, and Katsuhiro MIYAMOTO. "Alpha-particle autoradiography by solid state track detectors to spatial distribution of radioactivity in alpha-counting source." RADIOISOTOPES 38, no. 6 (1989): 282–85. http://dx.doi.org/10.3769/radioisotopes.38.6_282.

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24

Zheng, T., C. Villalobos, K. D. Nusser, et al. "Phenotypic characterization and functional correlation of alpha-MSH binding to pituitary cells." American Journal of Physiology-Endocrinology and Metabolism 272, no. 2 (1997): E282—E287. http://dx.doi.org/10.1152/ajpendo.1997.272.2.e282.

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It is clear that alpha-melanocyte-stimulating hormone (alpha-MSH), released by the hypophysial neurointermediate lobe, is a mediator of suckling-induced prolactin release, but several questions surrounding its role remain unresolved. Accordingly, the objectives of the present study were 1) to establish whether alpha-MSH could bind in a reversible manner to a specific secretory type cell within the adenohypophysis (AP), 2) to resolve the issue of whether the peptide could compete with dopamine for the same receptor binding site, and 3) to seek a functional signaling correlate for alpha-MSH bind

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25

IIDA, Takao, Yukimasa IKEBE, and Osamu MATSUOKA. "Autoradiography of .ALPHA.-and .BETA.-emitters using a charged-particle imaging system." RADIOISOTOPES 36, no. 7 (1987): 317–24. http://dx.doi.org/10.3769/radioisotopes.36.7_317.

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26

AL Darwish, R., E. Bezak, A. Staudacher, and M. Brown. "EP-1839: Application of timepix for autoradiography imaging in targeted alpha therapy." Radiotherapy and Oncology 111 (2014): S302—S303. http://dx.doi.org/10.1016/s0167-8140(15)31957-5.

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27

Schneider, Nathan R., S. E. Glover, Zhongyum Dong, and Henry B. Spitz. "Microdosimetry of alpha-emitting decay products in tissue using conventional film autoradiography." Journal of Radioanalytical and Nuclear Chemistry 307, no. 3 (2015): 2029–33. http://dx.doi.org/10.1007/s10967-015-4401-1.

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28

Chen, M. C., A. T. Lee, W. E. Karnes, et al. "Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha." American Journal of Physiology-Gastrointestinal and Liver Physiology 264, no. 2 (1993): G390—G396. http://dx.doi.org/10.1152/ajpgi.1993.264.2.g390.

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Studying primary cultures of replicating canine oxyntic mucosal cells, we found evidence for modulation of cell growth by endogenous factors. [3H]thymidine incorporation into DNA was rapid with cells cultured in medium free of serum or added growth factors, and growth rates of these cultures were markedly dependent on plating density, indicating mitogenic control by soluble endogenous growth factors. Data indicated that endogenous transforming growth factor-alpha (TGF-alpha) exerted mitogenic control under the following conditions. 1) TGF-alpha was detected in the cultured cells by radioimmuno

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29

Kirshner, N., J. J. Corcoran, and H. P. Erickson. "Synthesis of alpha 2-macroglobulin by bovine adrenal cortical cell cultures." American Journal of Physiology-Cell Physiology 256, no. 4 (1989): C779—C785. http://dx.doi.org/10.1152/ajpcell.1989.256.4.c779.

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Primary cultures of bovine adrenal medullary cells synthesize and secrete a high-molecular-weight protein into the culture medium. The protein was purified from the serum-free medium of cultured cells and was identified as alpha 2-macroglobulin by gel electrophoresis, sedimentation velocity, electron microscopy, immunoprecipitation, immunodiffusion, and autoradiography. Antisera directed against the protein were prepared and used to determine the cell types that synthesize the protein. Immunohistofluorescence studies show that adrenal cortical cells present in the adrenal medullary cell cultur

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30

Brown, J., and A. Czarnecki. "Receptor subtypes for natriuretic peptides in the brains of hypertensive rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 260, no. 2 (1991): R441—R447. http://dx.doi.org/10.1152/ajpregu.1991.260.2.r441.

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Receptor subtypes for alpha-atrial natriuretic peptide (alpha-ANP) were characterized in brains of 12-wk-old Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) by in vitro autoradiography, using des[Gln18, Ser19,Gly20,Leu21,Gly22]ANP-(4-23) (C-ANP) and ANP-(5-25) as subtype-selective ligands. 125I-labeled alpha-ANP (200 pM) bound reversibly to arachnoid mater (AM), choroid plexus (ChP), subfornical organ (SFO), median preoptic nucleus, and supraoptic nucleus. Apparent Kd values for alpha-ANP in AM, ChP, and SFO were 1-6 nM and they were lowest in SHR. Maximal binding capacities for a

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31

Tönnesmann, Roswitha, Philipp Meyer, Matthias Eder, and Ann-Christin Baranski. "[177Lu]Lu-PSMA-617 Salivary Gland Uptake Characterized by Quantitative In Vitro Autoradiography." Pharmaceuticals 12, no. 1 (2019): 18. http://dx.doi.org/10.3390/ph12010018.

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Irradiation of salivary glands remains the main dose-limiting side effect of therapeutic PSMA-inhibitors, especially when using alpha emitters. Thus, further advances in radiopharmaceutical design and therapy strategies are needed to reduce salivary gland uptake, thereby allowing the administration of higher doses and potentially resulting in improved response rates and better tumor control. As the uptake mechanism remains unknown, this work investigates the salivary gland uptake of [177Lu]Lu-PSMA-617 by autoradiography studies on pig salivary gland tissue and on PSMA-overexpressing LNCaP cell

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32

Puszkin, EG, EA Mauss, and MB Zucker. "Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor." Blood 76, no. 8 (1990): 1572–79. http://dx.doi.org/10.1182/blood.v76.8.1572.1572.

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Abstract The association between occupancy of the von Willebrand factor (vWf) receptor glycoprotein (GP) Ib, agglutination, and the assembly and composition of the cytoskeletal core was studied in 125I-surface- labeled aspirin-treated washed platelets. Binding of ligands to GPIIb- IIIa and platelet aggregation were abolished by addition of EDTA. Platelet agglutination induced by bovine vWf generated a complete cytoskeletal core (Triton-insoluble residue), shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to be composed of actin-binding protein (ABP) (260 Kd), 235-Kd

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Puszkin, EG, EA Mauss, and MB Zucker. "Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor." Blood 76, no. 8 (1990): 1572–79. http://dx.doi.org/10.1182/blood.v76.8.1572.bloodjournal7681572.

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The association between occupancy of the von Willebrand factor (vWf) receptor glycoprotein (GP) Ib, agglutination, and the assembly and composition of the cytoskeletal core was studied in 125I-surface- labeled aspirin-treated washed platelets. Binding of ligands to GPIIb- IIIa and platelet aggregation were abolished by addition of EDTA. Platelet agglutination induced by bovine vWf generated a complete cytoskeletal core (Triton-insoluble residue), shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to be composed of actin-binding protein (ABP) (260 Kd), 235-Kd protein,

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34

Brown, J., S. P. Salas, A. Singleton, J. M. Polak, and C. T. Dollery. "Autoradiographic localization of atrial natriuretic peptide receptor subtypes in rat kidney." American Journal of Physiology-Renal Physiology 259, no. 1 (1990): F26—F39. http://dx.doi.org/10.1152/ajprenal.1990.259.1.f26.

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The distribution of atrial natriuretic peptide (ANP) clearance receptors in rat kidney was investigated by in vitro autoradiography using des[Gln18,Ser19,Gly20,Leu21,Gly22]-ANP-(4- 23) (C-ANP) and 125I-Tyr0-ANP-(5-25) as relatively specific ligands of this receptor. Alpha-125I-ANP (100 pM) bound reversibly but with high affinity to glomeruli, outer medullary vasa recta bundles, and inner medulla. C-ANP (10 microM) inhibited greater than 60% of this glomerular binding but did not inhibit the binding of alpha-125I-ANP to medullary tissues. Alpha-125I-ANP also bound reversibly to the renal arteri

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35

SAITO, Hideo, and Fumio MORITO. "Visualization of Boron in Molybdenum by α-rays Track Etching Method and Tritium Autoradiography." Tetsu-to-Hagane 89, no. 7 (2003): 750–57. http://dx.doi.org/10.2355/tetsutohagane1955.89.7_750.

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36

Miller, Brian W. "Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters." Seminars in Nuclear Medicine 48, no. 4 (2018): 367–76. http://dx.doi.org/10.1053/j.semnuclmed.2018.02.008.

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37

Zeissler, Cynthia J. "Comparison of semiconductor pixel array, phosphor plate, and track-etch detectors for alpha autoradiography." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 392, no. 1-3 (1997): 249–53. http://dx.doi.org/10.1016/s0168-9002(97)00253-2.

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38

Sardini, Paul, Axel Angileri, Michael Descostes, et al. "Quantitative autoradiography of alpha particle emission in geo-materials using the Beaver™ system." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 833 (October 2016): 15–22. http://dx.doi.org/10.1016/j.nima.2016.07.003.

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39

Saffitz, J. E. "Distribution of alpha 1-adrenergic receptors in myocytic regions and vasculature of feline myocardium." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 1 (1989): H162—H169. http://dx.doi.org/10.1152/ajpheart.1989.257.1.h162.

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The physiological and pathophysiological roles of myocardial alpha 1-adrenergic receptors are not clearly defined. To delineate the distribution of alpha 1-receptors in myocytic and vascular components of the heart, we characterized the binding of [3H]prazosin to alpha 1-receptors in unfixed, transmural slices of feline left ventricle. Specific binding ratios greater than 95% were achieved at radioligand concentrations near the dissociation constant (Kd). Binding of radioligand to receptors in transmural slices was rapid, reversible, saturable, stereoselective, and displaceable by subtype-sele

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Samuels, BL, HM Golomb, and BH Brownstein. "In vivo induction of proteins during therapy of hairy cell leukemia with alpha-interferon." Blood 69, no. 6 (1987): 1570–73. http://dx.doi.org/10.1182/blood.v69.6.1570.1570.

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Abstract The mechanism of the antineoplastic effect of interferon (IFN) is not known and may result from direct effects on the neoplastic cells themselves, activation of intermediary effector cells, or a combination of these effects. The synthesis of specific proteins is induced in hairy cells when they are exposed to alpha-IFN in vitro. In particular, the called p80, is markedly induced. We investigated this effect in the hairy cells of seven patients in the leukemic phase of hairy cell leukemia who were being treated with subcutaneous (SC) IFN alpha 2b (r- Hu-IFN-alpha 2). Polyacrylamide gel

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Samuels, BL, HM Golomb, and BH Brownstein. "In vivo induction of proteins during therapy of hairy cell leukemia with alpha-interferon." Blood 69, no. 6 (1987): 1570–73. http://dx.doi.org/10.1182/blood.v69.6.1570.bloodjournal6961570.

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The mechanism of the antineoplastic effect of interferon (IFN) is not known and may result from direct effects on the neoplastic cells themselves, activation of intermediary effector cells, or a combination of these effects. The synthesis of specific proteins is induced in hairy cells when they are exposed to alpha-IFN in vitro. In particular, the called p80, is markedly induced. We investigated this effect in the hairy cells of seven patients in the leukemic phase of hairy cell leukemia who were being treated with subcutaneous (SC) IFN alpha 2b (r- Hu-IFN-alpha 2). Polyacrylamide gel electrop

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Machida, Toshifumi, Michiyoshi Taga, and Hiroshi Minaguchi. "Effects of epidermal growth factor and transforming growth factor alpha on the mouse trophoblast outgrowth in vitro." European Journal of Endocrinology 133, no. 6 (1995): 741–46. http://dx.doi.org/10.1530/eje.0.1330741.

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Machida T, Taga M, Minaguchi H. Effects of epidermal growth factor and transforming growth factor alpha on the mouse trophoblast outgrowth in vitro. Eur J Endocrinol 1995;133:741–6. ISSN 0804–4643 In order to analyze the involvement of growth factors in the implantation mechanism, we examined the direct effects of epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α) on trophoblast outgrowth of the mouse blastocyst in vitro. ICR mouse blastocysts were cultured for 4 days on a culture plate in medium containing EGF or TGF-α or conditioned medium obtained from cultured endom

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Ullah, Rahman, Nie Fengjuin, Zhang Xin, Zhang Chengyong, Asim Ali, and Zhang Pengfei. "Uranium Traps in Phreatic Sandstone-type Prospect, Taunsa Area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan: Evidences from Autoradiography and Optical Microscopy." International Journal of Economic and Environmental Geology 11, no. 1 (2020): 65–71. http://dx.doi.org/10.46660/ijeeg.vol11.iss1.2020.414.

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Taunsa uranium occurrence like other uranium resources in Pakistan is hosted by the Late Miocene-Pliocene age Litra Formation of the Siwalik Group molasse sediments. Taunsa uranium prospect is a unique phreatic-type uranium resource in terms of its disturbed geological setting of the eastern limb of the Zindapir anticline in the eastern Sulaiman range. Autoradiography technique was used to locate the spots of anomalous uranium concentration in thin sections from ore of Taunsa prospect. Twenty polished thin sections from uranium ore ranging from 200 ppm-600 ppm were attached to detectors for a

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Ullah, Rahman, Nie Fengjuin, Zhang Xin, Zhang Chengyong, Asim Ali, and Zhang Pengfei. "Uranium Traps in Phreatic Sandstone-type Prospect, Taunsa Area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan: Evidences from Autoradiography and Optical Microscopy." International Journal of Economic and Environmental Geology 11, no. 1 (2020): 65–71. http://dx.doi.org/10.46660/ojs.v11i1.414.

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Taunsa uranium occurrence like other uranium resources in Pakistan is hosted by the Late Miocene-Pliocene age Litra Formation of the Siwalik Group molasse sediments. Taunsa uranium prospect is a unique phreatic-type uranium resource in terms of its disturbed geological setting of the eastern limb of the Zindapir anticline in the eastern Sulaiman range. Autoradiography technique was used to locate the spots of anomalous uranium concentration in thin sections from ore of Taunsa prospect. Twenty polished thin sections from uranium ore ranging from 200 ppm-600 ppm were attached to detectors for a

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Rao, T. S., B. B. Shriwastwa, J. N. Dubey, et al. "Quantitative estimation of plutonium-rich areas in thorium-based MOX fuels using alpha autoradiography technique." Radiation Measurements 36, no. 1-6 (2003): 747–50. http://dx.doi.org/10.1016/s1350-4487(03)00239-7.

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Baghra, Chetan, D. B. Sathe, Jitender Sharma, et al. "Evaluation of micro-homogeneity in plutonium based nuclear reactor fuel pellets by alpha-autoradiography technique." Journal of Nuclear Materials 467 (December 2015): 730–41. http://dx.doi.org/10.1016/j.jnucmat.2015.10.058.

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Tanaka, H., Y. Sakurai, M. Suzuki, et al. "Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography." Applied Radiation and Isotopes 88 (June 2014): 153–56. http://dx.doi.org/10.1016/j.apradiso.2014.01.011.

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NICHOLAS, ANTHONY P., VINCENT PIERIBONE, ÅKE DAGERLIND, BJÖRN MEISTER, ROBERT ELDE, and TOMAS HÖKFELT. "A Complementary Method to Radioligand-Mediated Autoradiography for Localizing Adrenergic, Alpha-2 Receptor-Producing Cells." Annals of the New York Academy of Sciences 763, no. 1 The Imidazoli (1995): 222–42. http://dx.doi.org/10.1111/j.1749-6632.1995.tb32409.x.

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Hall, S. W., J. LaMarre, L. B. Marshall, M. A. Hayes та S. L. Gonias. "Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin-proteinase complexes". Biochemical Journal 281, № 2 (1992): 569–75. http://dx.doi.org/10.1042/bj2810569.

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The binding of 125I-labelled transforming growth factor-beta 1 (TGF-beta 1) to human alpha 2-macroglobulin (alpha 2M) was studied by native PAGE and autoradiography. TGF-beta 1 bound preferentially to alpha 2M-methylamine and minimally, if at all, to native alpha 2M. Preparations of alpha 2M-proteinase complex were generated by incubating a standard concentration of alpha 2M (0.4 microM) with different concentrations of trypsin, chymotrypsin or neutrophil elastase (0.04-2.0 microM). The 125I-TGF-beta 1-binding activity depended on the initial ratio of active proteinase to alpha 2M, or r value,

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Jones, S. M. A., and S. J. Yeaman. "Phosphorylation of branched-chain 2-oxo acid dehydrogenase complex in isolated adipocytes. Effects of 2-oxo acids." Biochemical Journal 236, no. 1 (1986): 209–13. http://dx.doi.org/10.1042/bj2360209.

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Isolated adipocytes from rat epididymal fat-pads were incubated with [32P]Pi, and intracellular phosphoproteins were then analysed by SDS/polyacrylamide-gel electrophoresis and autoradiography. A phosphorylated polypeptide of apparent Mr 46,000 was identified as the alpha-subunit of branched-chain 2-oxo acid dehydrogenase complex by immunoprecipitation using antiserum raised against the homogeneous E1 component of branched-chain 2-oxo acid dehydrogenase complex. Immunoprecipitation of this phosphoprotein is blocked in a competitive manner by purified branched-chain 2-oxo acid dehydrogenase com

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