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Gupta, Clare. "Sustainability, self-reliance and aloha aina: the case of Molokai, Hawai’i." International Journal of Sustainable Development & World Ecology 21, no. 5 (January 23, 2014): 389–97. http://dx.doi.org/10.1080/13504509.2014.880163.
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Grandinetti, Tina. "Urban aloha ‘aina: Kaka‘ako and a decolonized right to the city." Settler Colonial Studies 9, no. 2 (December 11, 2017): 227–46. http://dx.doi.org/10.1080/2201473x.2017.1409400.
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DAVIS, ROCÍO G. "‘‘I wish you a land'': Hawai'i Short Story Cycles and aloha ′aina." Journal of American Studies 35, no. 1 (April 2001): 47–64. http://dx.doi.org/10.1017/s0021875801006521.
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The artistic appropriation of place ranks among the central concerns of Asian American writing. Place in literature, a simultaneous geography of space and imagination, has the potential to represent communal formation and preservation as it highlights the identity that binds its members in a shared sense of purpose and a common sense of belonging. For first-generation writers, the portrayal of the land of the past often blends with that of the present, offering a vivid depiction of how immigrants perceive the physical and emotional journey from the geographic and temporal past to the present, as they struggle to establish themselves in the new surroundings. For second-generation Asian Americans, place often acquires another meaning, that of a definition of self in the place of birth, as they shift between visions of their parents' past location and their own cultural differences. Third-generation writers engage a wide spectrum of negotiations with the land that was a protagonists of their growing up, and that of their increasingly complex personal and community history. Consequently, a sense of place becomes one of the most significant elements the Asian American writer can manipulate to condition self-representation and the portrayal of community.
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Indriyanto, Kristiawan. "Resilience and Resistance: Indigenous Agency of Hawai’ian Indigene in Lynn Kalama Nakkim’s Mahele o Maui." OKARA: Jurnal Bahasa dan Sastra 16, no. 2 (November 15, 2022): 282–300. http://dx.doi.org/10.19105/ojbs.v16i2.6981.
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In recent years, the emergence of indigenous literature contextualizes the historicity of colonialism and the ensuing resistance. This present study articulates how the Native Hawai’ians articulate their resistance against American domination through the resilience of their cultural heritage and advocates for political changes, as is reflected in Lynn Kalama Nakkim’s Mahele o Maui. The study applied an econarratological perspective which foregrounds the reader's active role in reimagining a different socio-cultural perspective of the natural environment from Mahele’s perspective and engaging with other (non-Western) environmental imagination. The theory of resilience and resistance, as stated by Adamson and Molina, underlines how indigenous Hawai’ian tradition manages to persevere and transform through the Western model of narration, a novel. The study explores how Nakkim’s fiction articulates the indigenous epistemology of Aloha Aina to actively resist American domination with the eventual goal of achieving sovereignty and independence. The finding concludes how Native Hawai’ians’ literature has a similar concern with other indigenous struggles in the world, advocative and politically oriented in outlook, echoing their struggle for the right of self-determination and eventual sovereignty.
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Pashootanizadeh, Mitra, and Saideh Khalilian. "Application of the AIDA model." Information and Learning Science 119, no. 11 (November 12, 2018): 635–51. http://dx.doi.org/10.1108/ils-04-2018-0028.
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Purpose The purpose of this study is to measure how effective television programs are in persuading teenagers to use public libraries. Design/methodology/approach This study is a descriptive survey. The statistical population includes all members of public libraries in the City of Isfahan aged between 12 and 16 years (N = 920). Using Cochran’s formula, the sample size was determined to be 270 individuals. The data were collected by a researcher-made questionnaire survey instrument whose validity was confirmed by Library and Information Science experts. Furthermore, the reliability of the questionnaire was confirmed via “Cronbach’s alpha” in the pilot test with 0.73. Having a return rate of 85.93 per cent, the authors were able to analyze 232 sets of responses. Findings Based on the authors’ findings, television programs are only able to satisfy the first stage of the model (i.e. Attention). So, its role in encouraging teenagers to use public libraries is not significant. Among the items of the model, “Desirability and interest in the program” and “Persuading teenagers to use public libraries” were found to be the most and least effective items, respectively, with average responses of 8.42 and 5.13. Moreover, television shows categorized as kids/teenagers were most likely to attract the target audience to libraries. Originality/value There is no any similar study in this scope, especially in the Middle East, where watching the television remains a mainstream activity for teenagers. It is for the first time that AIDA model is used for measuring the effectiveness of television programs in persuading teenagers to use public libraries in Iran.
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Bapir, Rawa, Kamran Hassan Bhatti, Ahmed Eliwa, Herney Andrés García-Perdomo, Nazim Gherabi, Derek Hennessey, Vittorio Magri, et al. "Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis." Archivio Italiano di Urologia e Andrologia 94, no. 2 (June 30, 2022): 252–63. http://dx.doi.org/10.4081/aiua.2022.2.252.
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Background: Alpha-adrenoreceptor antagonists or alpha-blockers are used in the treatment of hypertension, in the therapy of benign prostatic hyperplasia and in medical expulsive treatment of ureteral stones. These agents may affect the sexual function, with differences between drugs within the same class, depending on their selectivity for receptor subtypes. The aim of this review was to analyze the effects of alpha-blockers on sexual function. Materials and methods: We conducted a systematic review and meta-analysis by searching PubMed, EMBASE and other databases for randomized controlled trials (RCTs) reporting sexual adverse effects in patients treated with alpha-blockers. Odds ratios for sexual dysfunction were calculated using random effects Mantel-Haenszel statistics. Results: Out of 608 records retrieved, 75 eligible RCTs were included in the meta-analysis. Compared with placebo, alphablockers were associated with increased odds of ejaculatory disorders both in patients with lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH) (OR: 7.53, 95% CI: 3.77-15.02, Z = 5.73, p < 0.00001, I2 = 55%) and in patients with ureteral stones (OR: 2.88, 95% CI: 1.50-5.44, Z = 3.19, p < 0.001, I2 = 31%). Uroselective alpha-blockers showed higher odds of ejaculatory disorders. Conversely, nonselective alpha-blockers were not associated with higher odds of ejaculatory dysfunction. Silodosin was associated with increased odds of ejaculatory dysfunction compared with tamsulosin (OR: 3.52, 95% CI: 2.18-5.68, 15 series, 1512 participants, Z = 5.15, p < 0.00001, I2 = 0%). Naftopidil and alfuzosin showed lower odds of ejaculatory dysfunction compared to uroselective alpha-blockers.No statistically significant differences in the odds of erectile dysfunction were observed when alpha-blockers were compared to placebo.
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Masuda, Hiroshi, Kosuke Mikami, Kotaro Otsuka, Kyokusin Hou, Takahito Suyama, Kazuhiro Araki, Satoko Kojima, and Yukio Naya. "Outcomes of dutasteride discontinuation in patients with benign prostatic hypertrophy." Archivio Italiano di Urologia e Andrologia 94, no. 4 (December 28, 2022): 521–24. http://dx.doi.org/10.4081/aiua.2022.4.521.
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To the Editor, Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in elderly males. The current guidelines recommend the use of a 5-alpha reductase inhibitor (5ARI) to treat males with moderate-to-severe LUTS and an enlarged prostate. Combination therapy with an alpha blocker and a 5ARI has proven effective at ameliorating LUTS and reducing the total prostate volume (TPV) and the risk of the disease progression.
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Giammusso, Bruno, Rosaria Di Mauro, and Renato Bernardini. "The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trial." Archivio Italiano di Urologia e Andrologia 89, no. 1 (March 31, 2017): 17. http://dx.doi.org/10.4081/aiua.2017.1.17.
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Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex condition, characterized by uncertain etiology and by limited response to therapy. The definition of CP/CPPS includes genitourinary pain with or without voiding symptoms in the absence of uropathogenic bacteria, as detected by standard microbiological methods, or another identifiable cause such as malignancy. The efficacy of various medical therapies, has been evaluated in clinical studies, but evidence is lacking or conflicting. We compared Serenoa Repens in monotherapy versus Palmitoylethanolamide (PEA) in combination with Alpha-lipoic acid (ALA) and evaluated the efficacy of these treatments in patients with CP/CPPS. Methods: We conducted a randomized, single-blind trial. 44 patients diagnosed with CP/CPPS (mean age 41.32 ± 1.686 years) were randomly assigned to treatment with Palmitoylethanolamide 300 mg plus Alpha-lipoic acid 300 mg (Peanase<sup>®</sup>), or Serenoa Repens at 320 mg. Three questionnaires (NIH-CPSI, IPSS and IIEF5) were administered at baseline and after 12 weeks of treatment in each group. Results: 12 week treatment with Peanase significantly improved the IPSS score compared to the same period of treatment with Serenoa Repens, and significantly reduced NIH-CPSI score. Similar results were observed in the different NIH-CPSI subscores break down. However, the same treatment did not result in significant improvement of the IIEF5 score. Both treatments did not produce undesired effects. Conclusions: The present results document the efficacy of an association of Palmitoylethanolamide (PEA) and Alpha-lipoic acid (ALA) administered for 12 weeks for treating patients with CP/CPPS, compared with Serenoa Repens monotherapy.
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Hori, M., M. Kitakaze, S. Takashima, T. Morioka, H. Sato, T. Minamino, K. Node, K. Komamura, M. Inoue, and T. Kamada. "AICA riboside improves myocardial ischemia in coronary microembolization in dogs." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 4 (October 1, 1994): H1483—H1495. http://dx.doi.org/10.1152/ajpheart.1994.267.4.h1483.
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This study was undertaken to examine whether 5-amino-4-imidazolecarboxamide (AICA) riboside (acadesine), which augments adenosine release in ischemic myocardium, further attenuates ischemic injury after acute coronary microembolization. The left anterior descending coronary artery was cannulated and perfused with blood from the left carotid artery in 46 dogs, and coronary blood flow (CBF) of the perfused area was measured. In 12 dogs, 15-microns microspheres (5.0 x 10(4)/ml) were injected repeatedly until CBF approached zero. Changes in CBF, fractional shortening, lactate extraction ratio, and adenosine release were measured with and without administration of AICA riboside. In the control group (n = 7), CBF increased to 154 +/- 11 ml.100 g-1.min-1 at 16-30% of total coronary embolization, and adenosine release was 6.1 +/- 1.0 nmol.100 g-1.min-1. Administration of AICA riboside (n = 5) enhanced coronary hyperemia (187 +/- 8 ml.100 g-1.min-1, P < 0.05), adenosine release (11.9 +/- 0.9 nmol.100 g-1.min-1, P < 0.001), and myocardial adenosine content (0.434 +/- 0.069 vs. 0.118 +/- 0.019 nmol/mg wet wt, P < 0.01) and attenuated decreases in fractional shortening and lactate extraction ratio. AICA riboside preserved myocardial tissue ATP content of the embolized area. The administrations of 8-phenyltheophylline (n = 12) and alpha,beta-methyleneadenosine 5'-diphosphate (n = 10) abolished the beneficial effects of AICA riboside. Furthermore, AICA riboside increased ectosolic and cytosolic 5'-nucleotidase activity of the embolized myocardium (n = 12). Thus we conclude that AICA riboside attenuates contractile and metabolic dysfunction by enhancing adenosine release via activation of ectosolic 5'-nucleotidase and inducing local hyperemia in acute coronary microembolization.
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Katafigioti, Amalia, Ioannis Katafigiotis, Stavros Sfoungaristos, Christos Alamanis, Konstantinos Stravodimos, Ioannis Anastasiou, Eleni Roumelioti, Mordechai Duvdevani, and Constantinos Constantinides. "In the search of novel urine biomarkers for the early diagnosis of prostate cancer. Intracellular or secreted proteins as the target group? Where and how to search for possible biomarkers useful in the everyday clinical practice." Archivio Italiano di Urologia e Andrologia 88, no. 3 (October 5, 2016): 195. http://dx.doi.org/10.4081/aiua.2016.3.195.
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Objective: To search which category of proteins can be detected in urine in order to examine subsequently its ability to improve our accuracy for the diagnosis of Prostate Cancer (PCa) as biomarkers in clinical useful fluids like urine and serum. Material and method(s): Urine samples of 127 patients were obtained after a vigorous transrectal prostatic massage to both lobes. The patients were considered to have a high risk for PCa according to their PSA (> 4 ng/ml), their digital rectal examination (DRE) (positive for suspicious prostatic lesions) or to their abnormal PSA kinetics (PSA velocity (PSAV > 0.75 ng/mL). All patients subsequently were subjected to an extended 10-core per prostatic lobe TRUS-b (total 20 prostatic samples). The proteins that were chosen to be detected in the urine samples with Western-blot, as possible biomarkers, were Glutathione peroxidase 3 precursor (GPx3), Cofilin-1 (CFL1), Heat shock protein-90β (HSP 90β), Zinc alpha 2-glycoprotein (ZAG) and secreted protein acidic and rich in cysteine (SPARC).These proteins have been detected previously in the prostatic tissue by proteomics proving their discriminative ability between patients with prostate cancer and benign prostatic hyperplasia. Result(s): From the five proteins, only the secreted Zinc alpha 2-glycoprotein was detected in urine showing a promising ability in the improvement of our diagnostic accuracy for the early diagnosis of prostate cancer. Conclusions: From various categories of proteins that have already been detected in the tissue of prostate by proteomics, only secreted protein Zinc alpha 2-glycoprotein showed a clear signal in the urine, proving its discriminative potential for the early diagnosis of PCa.
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Pirozzi Farina, Furio, and Antonella Pischedda. "Comments concerning the real risk of sexual adverse events secondary to the use of 5-ARIs." Archivio Italiano di Urologia e Andrologia 87, no. 4 (January 14, 2016): 312. http://dx.doi.org/10.4081/aiua.2015.4.312.
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Treatment-induced sexual dysfunctions (SD) are a recurrent and controversial topic in recent literature on the adverse events related to the use of 5-alpha-reductase inhibitors (5ARIs) (1, 2). In order to deal adequately with the various aspects of this topic, it is necessary to first cover some of the steps that allow a better definition and understanding of the subject.
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Avvisati, G., F. Lo Coco, D. Diverio, M. Falda, F. Ferrara, M. Lazzarino, D. Russo, MC Petti, and F. Mandelli. "AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study." Blood 88, no. 4 (August 15, 1996): 1390–98. http://dx.doi.org/10.1182/blood.v88.4.1390.bloodjournal8841390.
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From March 1993 to October 1993, 20 consecutive, newly diagnosed acute promyelocytic leukemia (APL) patients from 13 Italian institutions entered in a pilot study named AIDA, combining all-trans retinoic acid (ATRA) with idarubicin (IDA). ATRA was administered orally beginning on the first day of induction at the dosage of 45 mg/m2/d until complete remission (CR), whereas IDA was administered intravenously at the dosage of 12 mg/m2/d on days 2, 4, 6, and 8 of the induction. Patients who achieved CR were consolidated with 3 courses of chemotherapy without ATRA; thereafter, they were followed up for molecular and hematologic CR. The median age was 35.3 years (range, 6.5 to 67.6 years); 8 patients were males and 12 females; 4 had the hypogranular variant of APL (M3v), and 4 (2 with M3v) presented with leukocyte counts > or = 10,000/microL. Molecular analysis for the promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) hybrid gene at diagnosis was performed in 16 patients by means of reverse transcription-polymerase chain reaction (RT-PCR) analysis, and all were RT-PCR+ for the hybrid gene. In the remaining 4 patients, the cytogenetic study showed the presence of the t(15;17). After a median time of 36 days (range, 28 to 52 days) 18 (90%) patients achieved CR; the remaining 2 patients died 12 and 34 days after diagnosis from myocardial infarction caused by fungal myocarditis and from massive hemoptysis, respectively. ATRA syndrome was observed in only 2 patients, and, after the prompt discontinuation of ATRA and initiation of dexamethasone, both recovered from the syndrome. However, after recovering, 1 patient achieved CR, whereas the other died at day 34 because of massive hemoptysis; other side effects were very limited. At recovery from the third consolidation course, only 3 of 14 (21.4%) tested patients were RT-PCR+ for the PML-RAR alpha hybrid gene. Of these, 2 relapsed shortly afterwards; however, in the last patient, the PML-RAR alpha disappeared at successive testing performed 2 months later. As of September 30, 1995, after a median follow-up period from diagnosis of 27 months (range, 24 to 31 months), the overall survival and event-free survival durations are 85% and 69%, respectively; moreover, 14 of 18 (78%) patients who achieved CR are still alive and in first molecular and hematologic CR. Of the 4 relapsed patients, 3 achieved a second CR with ATRA and, after further treatment, are now in molecular and hematologic CR after 4+, 16+, and 17+ months from the second CR. These results indicate that (1) the AIDA protocol is highly effective in treating APL; (2) after 3 consolidation courses, the majority of patients who achieved CR are RT-PCR- for the hybrid gene PML-RAR alpha; (3) the persistence of an RT-PCR positivity for the PML- RAR alpha hybrid gene after 3 consolidation courses is indicative of early relapse, thus these patients still require additional treatment. These results have prompted the Gruppo Italiano Malattie Ematologiche Maligne dell′Adulto (GIMEMA) to initiate, in cooperation with the Associazione Italiana di Ematologia ed Oncologia Pediatrica and some European Organization for Research and Treatment of Cancer (EORTC) centers, a new multicentric clinical trial named AIDA LAP 0493 for the treatment of adult and pediatric APL patients. All patients are considered eligible if APL diagnosis is confirmed with molecular or cytogenetic studies for PML-RAR alpha hybrid gene or t(15;17) and are enrolled to receive the same induction and consolidation therapy of this pilot study. After consolidation, patients who are RT-PCR- for PML- RAR alpha hybrid gene are randomized to four arms, whereas patients who are RT-PCR+ after consolidation undergo, if eligible, an allogenic transplantation procedure.
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Zvereva, N. V., S. S. Voronova, M. V. Zvereva, and K. Goth. "RUSSIAN VERSION OF THE INTERNATIONAL QUESTIONNAIRE AIDA (”ASSESSMENT OF IDENTITY DEVELOPMENT IN ADOLESCENCE”)." PERSONALITY IN A CHANGING WORLD: HEALTH, ADAPTATION, DEVELOPMENT 10, no. 1 (36) (March 31, 2022): 17–22. http://dx.doi.org/10.23888/humj20221017-22.
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A new diagnostic tool for assessing personal development and its impairment in adolescents 12–18 years old is presented — the international questionnaire AIDA (Assessment of Identity Development in Adolescence), developed by Swiss authors K. Goth and K. Schmeck in 2012. The tool was conceived by the authors as a questionnaire for international use. It has been translated in European, Latin American and Asian countries. Author's requirement to national translations is to reflect the national specifics as much as possible in the wording of all items of the questionnaires. Since 2017, work has been underway to standardize the Russianlanguage version of the questionnaire. The article contains information about the tool itself, the purposes of its creation by the authors and about the work on the Russian-language version within the frameworkof the international program for the cultural adaptation of the questionnaire. The materials of the stages of work, given by the c reator s of the ques tionnaires , the main psychometric properties: Cronbac's alpha, exploratory factor analysis, multivariate analysis of variance are presented. The results of the assessment of the questionnaire in the clinic in 20 adolescents of both sexes with schizotypal personality disorder, examined in the clinic of the Mental Health Research Centre in a hospital or on an outpatient basis, are presented. The results of using the questionnaire showed significant differences between the samples of adolescents with schizotypal disorder and the normative sample, which may be important for building an individual psychotherapeutic program for working with a teenager, as well as for solving differential diagnostic and research questions in borderline psychiatryof adolescence.
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Busetto, Gian Maria, Francesco Del Giudice, Daniele D'Agostino, Daniele Romagnoli, Andrea Minervini, Bernardo Rocco, Alessandro Antonelli, et al. "Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature." Archivio Italiano di Urologia e Andrologia 91, no. 4 (January 13, 2020): 205–10. http://dx.doi.org/10.4081/aiua.2019.4.205.
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Background: Combination therapy with 5 alpha-reductase inhibitor (5-ARI) and alpha-blocker can be considered as a gold standard intervention for medical management of lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH). On the other hand, 5-ARI monotherapy and in particular Finasteride alone is currently getting focus of attention especially due to lack of systematic reviews investigating efficacy outcomes and/or adverse events associated. Objectives: Aim of the present critical review was to analyze current knowledge of clinical efficacy and incidence of adverse events associated with 5-ARI treatment for LUTS/BPH. Materials and methods: A systematic review of clinical trials of the literature of the past 20 years was performed using database from PubMed, Cochrane Collaboration and Embase. A total of 8821 patients were included in this study and inclusion criteria for studies selection were: data from randomized clinical trials (RCTs) focusing their attention on the clinical role of Finasteride monotherapy for symptomatic BPH. Parameters of research included prostate specific antigen (PSA), prostate volume (PV), International Prostate Symptom Score (IPPS), postvoid residual urine (PVR), voiding symptoms of IPSS (voiding IPSS), maximum urinary flow rate (Qmax), and adverse events (AEs). Results: Overall 12 original articles were included and critically evaluated. Sample sizes of patient actively treated with finasteride varied from 13 to 1524 cases analyzed in a single study. Follow-up after treatments ranged from 3 to 54 months. The effect of finasteride in reducing prostate volume (PV) was moderate (standardized mean difference (SMD) effect between 0.5 to 0.8 for all trials evaluable) while the effect on IPSS score and Qmax was considered significant (SMD in the 0.2 to 0.5 variation range). No severe AEs and/or psychiatric disorders were retrieved among the studies. Sexual health dysfunctions were significantly influenced by finasteride therapy when compared with placebo treated patients. Conclusions: Although significant clinical benefits of finasteride monotherapy were demonstrated, the effective size of the available reports included in the analysis is limited. Additional head-to-head studies would be needed to re-evaluate clinical efficacy and safety of 5-ARI in combination or not with alpha blockers.
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Mudoni, Anna, Francesco Caccetta, Maurizio Caroppo, Fernando Musio, Antonella Accogli, Maria Dolores Zacheo, Domenica Maria Lucia Burzo, Giancamillo Carluccio, and Vitale Nuzzo. "Bladder neck disease and kidney damage." Archivio Italiano di Urologia e Andrologia 86, no. 4 (December 30, 2014): 391. http://dx.doi.org/10.4081/aiua.2014.4.391.
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Primary bladder neck obstruction (PBNO) was first described in men by Marion in 1933. The precise cause of PBNO has not been clearly elucidated. This paper review the theories on etiology, clinical presentation, diagnostic evaluation and treatments for PBNO. Also this paper focuses on management of patients with complications like acute urine retention, hydroureteronephrosis and severe renal failure. The treatment options for men and women with PBNO include careful clinical evaluation, pharmacotherapy with alpha-blockers and surgical intervention.
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Pastore, Antonio Luigi, Yazan Al Salhi, Andrea Fuschi, Alessia Martoccia, Gennaro Velotti, Lorenzo Capone, Giorgio Bozzini, et al. "Successful treatment with pollen extract of hematospermia in patients with xanthogranolomatous prostatitis." Archivio Italiano di Urologia e Andrologia 91, no. 1 (March 29, 2019): 22–24. http://dx.doi.org/10.4081/aiua.2019.1.22.
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Introduction: The aim of this study was to report our experience in the management of hematospermia observed in 16 patients suffering from xanthogranulomatous prostatitis. Methods: Recurrent episodes of hematospermia were the onset symptom in all patients, and in 25% of patients it was combined with fever. All patients reported PSA value elevation and the digital rectal examination (DRE) revealed an increase of the gland size and of its consistency in all cases. In all patients, the hematospermia was treated with the oral administration of two tablets of pollen extract in a single (1 g) dose daily for 30 days. Results: Sixteen patients were observed between 2008 and 2016, referring hematospermia, progressive lower urinary tract symptoms (LUTS), and serum PSA level increase. To exclude the prostate cancer presence all patients were submitted to transperineal TRUS guided biopsy. In all the patients complete resolution of hematospermia was achieved treatment with pollen extract. All patients were subsequently treated for LUTS (alpha-adrenergic blockers), but none reported any significant improvement of symptoms. Basing on these pieces of evidence, after 90 days of alpha-blockers therapy, all patients underwent bipolar TURP. Histological examination of resected prostatic tissue revealed in all patients the diagnosis of xanthogranulomatous prostatitis. Conclusions: Patients with xanthogranulomatous prostatitis especially experience irritative symptoms, sometimes combined with fever or hematospermia. Hematospermia as the onset symptom has not been reported so far. The administration of the pollen extract for 30 days was associated with a complete resolution of hematospermia.
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Trinchieri, Alberto, Gianpaolo Perletti, Vittorio Magri, Konstantinos Stamatiou, Margherita Trinchieri, and Emanuele Montanari. "Drug-induced gynecomastia: A systematic review and meta-analysis of randomized clinical trials." Archivio Italiano di Urologia e Andrologia 93, no. 4 (December 21, 2021): 489–96. http://dx.doi.org/10.4081/aiua.2021.4.489.
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Objective: To review the evidence concerning treatment-related gynecomastia in patients taking spironolactone, antiandrogens, 5 alpha-reductase inhibitors, lipid-lowering and psychotropic drugs. Material and methods: A search of Medline and EMBASE was performed up to 30 June 2021. We included randomized controlled trials comparing the effects of a drug belonging to these classes versus placebo or versus a drug of the same class. Results: A total of 32 randomized controlled trials were included in the final review. There was an increased odds of gynecomastia in men receiving antiandrogens (OR = 17.38, 95% CI: 11.26 to 26.82; 6 trials, 9599 participants) and 5 alpha-reductase inhibitors compared to controls (OR = 1.77, 95% CI: 1.53 to 2.06; 7 series out of 6 trials, 34860 participants). The use of spironolactone in mixed gender populations was characterized by significantly higher odds of having gynecomastia compared to controls (OR = 8.39, 95% CI: 5.03 to 13.99; 14 trials, 3745 participants). No placebo-controlled trials focusing on the risk of gynecomastia in patients taking antipsychotic drugs was available, although there was a significant difference in the odds of having gynecomastia in a comparison between risperidone and quetiapine (OR = 4.32, 95% CI: 1.31 to 14.27; 3 trials, 343 participants). Limited evidence about the effects of statins on mammary glands was found. Conclusions: Antiandrogens and to a lesser extent 5 alphareductase inhibitors and spironolactone are associated with an increased risk of developing gynecomastia. Such effect can be explained by a modification of the testosterone to estradiol ratio. Gynecomastia (and galactorrhea) associated to the use of conventional and certain atypical antipsychotics can be related to high prolactin levels.
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Gómez-Guerrero, C., M. J. López-Armada, E. González, and J. Egido. "Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation." Journal of Immunology 153, no. 11 (December 1, 1994): 5247–55. http://dx.doi.org/10.4049/jimmunol.153.11.5247.
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Abstract IgA nephropathy, a primary glomerulonephritis, is principally characterized by mesangial deposits of IgA immune complexes. Recently, it has been demonstrated that cultured glomerular mesangial cells (MC) express Fc alpha and Fc gamma receptors. In this work, we studied whether the interaction of soluble aggregates of IgA and IgG (AIgA and AIgG) with MC triggers a number of responses, including generation and release of inflammatory mediators, cell proliferation, and catabolism of the complexes. Aggregates bound to MC and were catabolized in a time-dependent manner. The percentage of cell-associated or -degraded proteins decreased in the presence of Fc, but not with Fab fragments. Both AIgA and AIgG elicited the synthesis and release of TNF-alpha and IL-6 in a dose-dependent manner, reaching a maximum between 6 and 12 h, respectively. Northern blot analysis showed that both aggregates induced the expression of mRNA encoding TNF-alpha and IL-6. Because MC proliferation is a morphologic feature commonly observed in patients with IgA nephropathy, we examined whether immune aggregates could be involved in this phenomenon. Both AIgA and AIgG induced an increase in MC number, assessed by [3H]thymidine and methylene blue uptake. The presence of anti-TNF-alpha or anti-IL-6 Abs in the medium decreased the proliferative effect triggered by aggregates. These results show that Fc alpha and Fc gamma receptor occupancy of MC induces the synthesis and release of inflammatory cytokines and proliferation, as well as the phagocytosis of stimulatory proteins. These findings could have implications for the understanding of inflammation and repair in IgA nephropathy.
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Çelik, Serdar, Firat Akdeniz, Muge Afsar Yildirim, Ozan Bozkurt, Merve Gursoy Bulut, Mehmet Levent Hacihasanoglu, and Omer Demir. "Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones." Archivio Italiano di Urologia e Andrologia 90, no. 2 (June 30, 2018): 117. http://dx.doi.org/10.4081/aiua.2018.2.117.
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Objectives: To evaluate the effect of tadalafil compared with four alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive treatment for ureteral stones in male adults. Materials and methods: Male adults who were admitted to urology clinic with flank pain and diagnosed with non complicated < 10 mm ureteral stone on non-contrast computed tomography (NCCT) between June 2014-September 2015 were retrospectively evaluated. A total of 273 patients with ureteral stone were divided into five groups. Alfuzosin 10 mg/daily, doxazosin 8 mg/daily, tamsulosin 0.4 mg/daily, silodosin 8 mg/daily and tadalafil 5 mg/daily for 6 weeks were prescribed respectively. Stone localization, diameter, volume and Hounsfield units were noted as NCCT findings. The patients were divided into the two groups based on their stone localization as distal and mid-proximal stones. These two groups were evaluated separately. Expulsion rate were noted at the end of 6 weeks. NCCT and treatment findings were compared between five drug groups in distal and mid-proximal stones separately. Results: Age was higher in tadalafil group in distal stones (p = 0.032). Expulsion rate was found 78.1% for alfuzosin, 75.7% for doxazosin, 76.5% for tamsulosin, 88.6% for silodosin and 90% for tadalafil in distal (p = 0.44) and 21.7%, 30%, 30%, 30% and 54.5% in mid-proximal stones (p = 0.034) respectively.Conclusions: Expulsion rate was higher in silodosin and tadalafil for distal ureteral stones but the difference didn’t meet statistical significance. However the expulsion rate was significantly higher in tadalafil than in the other groups for mid-proximal ureteral stones. The result of this study showed that tadalafil may increases ureteric stone expulsion.
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Sentürk, Aykut Buğra, Cemil Aydin, Musa Ekici, Muhammet Yaytokgil, Ali Akkoc, and Mehmet Murat Baykam. "Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study." Archivio Italiano di Urologia e Andrologia 90, no. 1 (March 31, 2018): 25. http://dx.doi.org/10.4081/aiua.2018.1.25.
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Purpose: In this study, we compared the effects of three agents frequently used in daily life for medical expulsive therapy. Materials and methods: A total of 143 patients meeting the criteria were included in the study. Patients were divided into three homogeneous drug groups which were tamsulosin group (n:48), alfuzosin group (n:47) and silodosin group (n:48). The time of stone expulsion, analgesic needs, side effects of the medicine and endoscopic intervention needs of the patients were recorded. Results: The rate of stone expulsion was 70.8% (n:34) in tamsulosin group, 70.2% (n:33) in alfuzosin group, and 75% (n:36) in silodosin group. No significant difference was observed among the rates of stone expulsion in three groups, and the rates of stone expulsion were similar (p = 0.778). The duration of stone expulsion was significantly different in the groups (p = 0.012): the time of stone expulsion for tamsulosin was 2.33 ± 0.78 days longer than for Silodosin, indicating a significant difference. There was no significant difference between tamsulosin-alfuzosin and silodosin-alfuzosin (respectively p = 0.147, p = 0.925). Conclusions: The results of this study showed that medical expulsive therapy by using alpha blocker agents is safe and efficacious. This option must be kept in mind for patients who do not ask for surgery as the first-step treatment for eligible patients.
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Anastasiou, Ioannis, Spyridon Skoufias, Ioannis Katafigiotis, Ioannis Skarmoutsos, and Constantinos A. Constantinides. "B-lymphocytic infiltration of the prostate to a patient with chronic lymphocytic leukemia. A case report." Archivio Italiano di Urologia e Andrologia 89, no. 1 (March 31, 2017): 83. http://dx.doi.org/10.4081/aiua.2017.1.83.
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Involvement of the prostate gland, as an early extra-nodal manifestation of a hematologic disease, or as a secondary infiltration is rare. Even rarer is the acute urinary retention due to infiltration by lymphocytes and simultaneously enlarged prostate. We present a case of a 61 years old male patient with a history of chronic lymphocytic leukemia, who was under oncological follow-up with no active treatment and had typical lower urinary tract symptoms due to benign prostatic hyperplasia and was receiving 5-alpha reductase inhibitor. After an acute urinary retention episode which was managed with a suprapubic catheter due to urethral catheter insertion failure, the patient was submitted to a transurethral prostatectomy. Histological examination revealed lymphocytic infiltration of the prostatic parenchyma by mostly small B cells. B-lymphocytic infiltration of the prostate gland, causes symptoms similar to benign prostatic hyperplasia. Acute urinary retention due to B-lymphocytic infiltration of the prostate is rare and the diagnosis is always histological and an oncological re-evaluation is necessary. The prognosis of these patients is related to the generalized disease rather than to the prostatic involvement.
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Skrotzki, J., P. Connolly, M. Schnaiter, H. Saathoff, O. Möhler, R. Wagner, M. Niemand, V. Ebert, and T. Leisner. "The accommodation coefficient of water molecules on ice-cirrus cloud studies at the AIDA simulation chamber." Atmospheric Chemistry and Physics Discussions 12, no. 9 (September 18, 2012): 24351–93. http://dx.doi.org/10.5194/acpd-12-24351-2012.
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Abstract. Cirrus clouds and their impact on the Earth's radiative budget are subjects of current research. The processes governing the growth of cirrus ice particles are central to the radiative properties of cirrus clouds. At temperatures relevant to cirrus clouds, the growth of ice crystals smaller than a few microns in size is strongly influenced by the accommodation coefficient of water molecules on ice, αice, making this parameter relevant for cirrus cloud modeling. However, the experimentally determined magnitude of αice for cirrus temperatures is afflicted with uncertainties of almost three orders of magnitude and values for αice derived from cirrus cloud data lack significance so far. This has motivated dedicated experiments at the cloud chamber AIDA (Aerosol Interactions and Dynamics in the Atmosphere) to determine αice in the cirrus-relevant temperature interval between 190 K and 235 K under realistic cirrus ice particle growth conditions. The experimental data sets have been evaluated independently with two model approaches: the first relying on the newly developed model SIGMA (Simple Ice Growth Model for determining Alpha), the second one on an established model, ACPIM (Aerosol-Cloud-Precipitation Interaction Model). Within both approaches, a careful uncertainty analysis of the obtained αice values has been carried out for each AIDA experiment. The results show no significant dependence of αice on temperature between 190 K and 235 K. In addition, we find no evidence for a dependence of αice on ice particle size or on water vapor supersaturation for ice particles smaller than 20 μm and supersaturations of up to 70%. The temperature averaged and combined result from both models is αice=0.6−0.4+0.4 which implies that αice may only exert a minor impact on cirrus clouds and their characteristics when compared to the assumption of αice=1. Impact on prior calculations of cirrus cloud properties, e.g. in climate models, with αice typically chosen in the range 0.2–1 is thus expected to be negligible. In any case, we provide a well constrained αice which future cirrus model studies can rely on.
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Skrotzki, J., P. Connolly, M. Schnaiter, H. Saathoff, O. Möhler, R. Wagner, M. Niemand, V. Ebert, and T. Leisner. "The accommodation coefficient of water molecules on ice – cirrus cloud studies at the AIDA simulation chamber." Atmospheric Chemistry and Physics 13, no. 8 (April 29, 2013): 4451–66. http://dx.doi.org/10.5194/acp-13-4451-2013.
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Abstract. Cirrus clouds and their impact on the Earth's radiative budget are subjects of current research. The processes governing the growth of cirrus ice particles are central to the radiative properties of cirrus clouds. At temperatures relevant to cirrus clouds, the growth of ice crystals smaller than a few microns in size is strongly influenced by the accommodation coefficient of water molecules on ice, αice, making this parameter relevant for cirrus cloud modeling. However, the experimentally determined magnitude of αice for cirrus temperatures is afflicted with uncertainties of almost three orders of magnitude, and values for αice derived from cirrus cloud data lack significance so far. This has motivated dedicated experiments at the cloud chamber AIDA (Aerosol Interactions and Dynamics in the Atmosphere) to determine αice in the cirrus-relevant temperature interval between 190 K and 235 K under realistic cirrus ice particle growth conditions. The experimental data sets have been evaluated independently with two model approaches: the first relying on the newly developed model SIGMA (Simple Ice Growth Model for determining Alpha), the second one on an established model, ACPIM (Aerosol-Cloud-Precipitation Interaction Model). Within both approaches a careful uncertainty analysis of the obtained αice values has been carried out for each AIDA experiment. The results show no significant dependence of αice on temperature between 190 K and 235 K. In addition, we find no evidence for a dependence of αice on ice particle size or on water vapor supersaturation for ice particles smaller than 20 μm and supersaturations of up to 70%. The temperature-averaged and combined result from both models is αice = 0.7−0.5+0.3, which implies that αice may only exert a minor impact on cirrus clouds and their characteristics when compared to the assumption of αice =1. Impact on prior calculations of cirrus cloud properties, e.g., in climate models, with αice typically chosen in the range 0.2–1 is thus expected to be negligible. In any case, we provide a well-constrained αice which future cirrus model studies can rely on.
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Bayraktar, Zeki, and Selami Albayrak. "Metastasis of renal cell carcinoma to the thyroid gland 9 years after nephrectomy: A case report and literature review." Archivio Italiano di Urologia e Andrologia 89, no. 2 (June 30, 2017): 151. http://dx.doi.org/10.4081/aiua.2017.2.151.
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We report a case presenting with thyroid and lung metastases of renal cell carcinoma that was treated with molecular targeted therapy followed metastasectomy. A 52-year-old female underwent radical nephrectomy of right renal cell carcinoma in 2007. The patient presented 9 years after nephrectomy at the age of 61 years with sudden loss of vision on the left side and a mass on the neck. On magnetic resonance imagining, there was a mass on the midline of the neck, extending to the left, measuring 46 x 31 mm and containing central cystic-necrotic areas. Fine-needle aspiration biopsy was performed. The histopathological examination of the biopsy specimen revealed a lesion composed of malignant epithelial cells compatible with metastasis of renal carcinoma. Computed tomography showed multiple metastases in bilateral lungs. Metastasectomy and total tiroidectomy were performed. Thyroid and lung metastasis of renal cell carcinoma were pathologically confirmed. But on the first computed tomography after metastasectomy, there was residual tumor in the thyroid. Interferon-alpha therapy was given for 8 weeks. After that, pazopanib therapy started. Three months later, on computed tomography, residual metastatic foci were regressed. The patient was followed up for 1 year after metastasectomy. The patient is currently receiving a single dose of pazopanib per day (400 mg/day) and the general condition is good. Thyroid metastasis should be considered in patients with a thyroid nodule and positive history for renal cell carcinoma. Successful results can be obtained with metastasectomy and systemic targeted therapy.
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Figueiredo, Maria S., Leandro S. D’Abronzo, Melca M. Oliveira, Juliana L. Dreyfuss, and Jose Orlando Bordin. "Influence of Polymorphisms of Pro-Inflammatory (IL-12, TNFa and LTa) and Anti-Inflammatory Factors (IL-10 and CTLA4) in Autoimmune Hemolytic Anemia." Blood 110, no. 11 (November 16, 2007): 3751. http://dx.doi.org/10.1182/blood.v110.11.3751.3751.
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Abstract The Autoimmune Hemolytic Anemia (AIHA) is caused by the destruction of antibody-coated red blood cells, but mechanisms that initiate the production of autoantibodies remains unclear. It had been suggest that decreased production of Th1-type cytokines and production of autoantibodies in AIHA can be secondary to the imbalance between anti- and pro-inflammatory factors. Moreover, the presence of single nucleotide polymorphisms (SNPs) showed association with different production of immunoregulatory factors which may modulate the disease expression in AIHA. OBJECTIVES: To determine the importance of SNPs of pro- and anti-inflammatory factors in the development of AIHA. PATIENTS: We studied 17 patients with AIHA who has been followed in the Hematology and Blood Transfusion Unit at the Federal University of Sao Paulo (UNIFESP/EPM), Brazil. The control group was composed by 40 healthy volunteer blood donors. METHODS: After DNA extraction from peripheral blood samples, the frequency of the SNPs was determinate by PCR-RFLP in patients and healthy individuals. The following SNPs were analyzed: Interleukin 12: IL-12 1188 (A/C), Tumor Necrosis Factor alpha: TNFa-308 (G/A), and Lymphotoxin alpha: Lta +252 (A/G); Interleukin 10: IL-10-592 (C/A), and Cytotoxic T-lymphocyte associated protein 4: CTLA4 exon 1 49 (A/G). RESULTS: The patient group was composed predominantly by female individuals (14 or 82%) and the median of age was 56 years old (18 to 76 years). The frequency observed for each allele studied in the patient group was: allele A of IL-12 = 0.82; allele G of FNTa = 0.85; allele A of Lta = 0.68; allele C of IL-10 = 0.82; allele G of CTLA4 = 0.59. No differences in allele frequency were found between patient and control groups. CONCLUSIONS: Our results suggest that these polymorphisms appear not to contribute for the development of the AIHA.
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Brardi, Simone, Giuseppe Romano, and Gabriele Cevenini. "Preliminary results of a randomized crossover clinical trial comparing a new electromagnetic and vibrating device and alpha-blocker agents in patients affected by bladder outlet obstruction secondary to benign prostatic hyperplasia." Archivio Italiano di Urologia e Andrologia 93, no. 4 (December 22, 2021): 501–4. http://dx.doi.org/10.4081/aiua.2021.4.501.
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To the Editor, Benign Prostatic Hyperplasia (BPH) is one of the main causes of patients seeking urological counselling in Western countries. It has been estimated that nearly 70 percent of United States men between the ages of 60 and 69 years, and nearly 80 percent of men ≥ 70 years, have some degree of BPH [...].
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Narter, Kamil Fehmi, Utku Can, Alper Coşkun, Kubilay Sabuncu, and Fatih Tarhan. "The role of anticholinergic therapy based on the upoint system in the treatment of chronic prostatitis." Archivio Italiano di Urologia e Andrologia 91, no. 1 (March 29, 2019): 16–21. http://dx.doi.org/10.4081/aiua.2019.1.16.
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Objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common problem and severely impairs the quality of life (QoL). We aimed to investigate the effects of different treatment options on voiding symptoms and QoL in patients with urinary phenotype according to the UPOINT system. Matherial and methods: Ninety-six patients with NIH category II,III CP/CPPS were included in the study prospectively. After the diagnosis, the questionnaires including NIH Chronic prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS), Overactive Bladder Screening Questionnaire (OAB-V8), and Beck depression inventory were filled by the patients. The patients with urinary phenotype were treated by alpha-blocker, antimuscarinic or both therapy modalities (combined) considering the specific therapy recommendations by UPOINT. The questionnaires applied on the first visit were reapplied after one month and treatment success was evaluated. Results: Seventy-three patients were included in ‘Urinary phenotype’ group (76%) and 23 were included in ‘other phenotypes’ (24%) group of the patients according to the UPOINT classification. Significant improvements of symptoms were observed with the all treatment modalities when the NIH-CPSI, IPSS and OAB-V8 scores were compared before and after treatment in the ‘Urinary phenotype’ group. Significant differences in the percentage of change in values were obtained in the anticholinergic group for pain subdomain of NIH-CPSI and IPSS scores.Conclusion: U-POINT clasification is useful for deciding on the treatment modality in CP/CPSS patients. We showed anticholinergic therapy might be effective option. Addition to the symptomatic recovery, there is need more further studies about effectivity cholinergic system in the prostate tissue.
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Duque, N., C. Gómez-Guerrero, and J. Egido. "Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10." Journal of Immunology 159, no. 7 (October 1, 1997): 3474–82. http://dx.doi.org/10.4049/jimmunol.159.7.3474.
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Abstract The mechanisms of glomerular damage in IgA nephropathy remain undefined. Mesangial cells (MC) possess Fc receptors for IgA (Fc alpha R), and their occupancy triggers cytokine expression, cell proliferation, and extracellular matrix synthesis. In cultured human MC we examined the effects of soluble IgA aggregates (AIgA) on the activation of nuclear factor-kappa B (NF-kappa B) and the production of proinflammatory chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8, and IFN-inducible protein-10 (IP-10). The exposure of MC to AIgA rapidly activated a NF-kappa B complex constituted of p50 and p65 subunits. NF-kappa B activation was dose dependent, abolished by preincubation with IgA Fc fragments (indicating that AIgA effects occur via specific Fc alpha R), and attenuated by kinase inhibitors. MC stimulation with AIgA increased the mRNA expression of MCP-1, IL-8, and IP-10 in a time- and dose-dependent manner. Maximal expression of IL-8 was observed at 3 h (4.5-fold), while IP-10 and MCP-1 peaked at 6 h (5-fold for both). AIgA also induced biosynthesis and release of the chemokines, which presented biological activity in neutrophil and monocyte chemoattractant assays, peaking at 6 and 9 h, respectively. MC pretreatment with the antioxidant pyrrolidine dithiocarbamate inhibited NF-kappa B activation and chemokine mRNA expression. This study shows that stimulation of Fc alphaR in MC induces gene expression of MCP-1, IL-8, and IP-10, a process partially mediated by NF-kappa B activation. These data may be of importance for a better understanding of the pathogenesis of glomerular damage in IgA immune complex-related diseases.
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Sbrollini, Giulia, Alessandro Conti, Andrea Benedetto Galosi, Vito Lacetera, Rodolfo Montironi, Lorenzo Montesi, and Giovanni Muzzonigro. "Perivascular epithelioid cell tumor (PEC-ome) of the prostate: Ultrasound feature in case report." Archivio Italiano di Urologia e Andrologia 86, no. 4 (December 30, 2014): 393. http://dx.doi.org/10.4081/aiua.2014.4.393.
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Introduction: We describe a rare tumor arising from the prostate gland: Perivascular Epithelioid Cells tumor (PEC-ome). A 54-years old was treated for acute urinary retention with alpha-blockers at presentation due to benign prostate enlargement (65 cc) with asymmetric middle lobe and regular PSA (0.92 ng/ml). After 5 months, patient developed a second acute urinary retention episode and nodules in the left lung; he was treated with transurethral resection of the prostate and left lobectomy. Results: Histological examination of prostate and lung tissue gave the same diagnosis: leiomyosarcoma with atypical morphological features and patient was observed for 4 months. Considering the uncommon diagnosis, pathological review by the uro-pathologist at our Hospital was done. Additional immunohistochemistry was done and both tumors showed similar and typical features of metastatic PEC-ome (T1b N0 M1). Therefore a new staging showed local and distant progression with prostatic mass and small lung metastasis. Three cycles of Gemcitabine and Pazopanib were administered, but 2 months later a new urinary retention occurred, despite chemotherapy. Patient referred to our Hospital for salvage pelvic surgery with lymph node dissection. Final pathological diagnosis was PECome of the prostate stage pT4 pN0 R0 M1. Conclusions: PEC-ome is a rare but rapidly invasive mesothelial tumor with early metastatic potential. When this tumors originates from the fibromuscular stroma of the prostate it mimics benign prostatic enlargement and causes LUTS. Expert pathology aided by immunoisthochemistry is the cornerstone of diagnosis. There are no pathognomonic imaging on ultrasound or symptoms suggesting the presence of PECome in early stage. A multidisciplinary approach is necessary and radical surgery should be done to treat this aggressive cancer.
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Cantoro, Ubaldo, Francesco Catanzariti, Vito Lacetera, Luigi Quaresima, Giovanni Muzzonigro, and Massimo Polito. "Comparison of tamsulosin vs tamsulosin/sildenafil effectiveness in the treatment of erectile dysfunction in patients affected by type III chronic prostatitis." Archivio Italiano di Urologia e Andrologia 85, no. 3 (September 26, 2013): 109. http://dx.doi.org/10.4081/aiua.2013.3.109.
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Aim: We evaluated the effectiveness of tamsulosin monotherapy versus tamsulosin plus sildenafil combination therapy on erectile dysfunction (ED) in young patients with type III chronic prostatitis and ED by using symptom score scales. Materials and methods: 44 male patients were divided into 2 groups: the first group (20 patients) was treated with tamsulosin 0,4 mg monotherapy and the second one 24 patients) was treated with tamsulosin 0,4 mg plus sildenafil 50 mg combination therapy. “International Prostate Symptom Score” (IPSS), “National Institute of Health Chronic Prostatitis Symptom Index” (NIH-CPSI) and “International Index of Erectile Function” (IIEF-5) were inves- tigated in each group of patients, and scores calculated during the first medical examination. Both groups were treated with tamsulosin once daily for 60 days, while sildenafil 50 mg was given on demand (at least 2 times per week) for 60 days. During the second medical examination IPSS, NIH-CPSI and IIEF-5 scores were analyzed once more. Afterwards, the alterations of scores among medical examinations in each group and between both groups were statistically compared. Results: The age average of the 44 cases included was 32.04 ± 3.15 years. Both groups present a statistically significant decrease, between the first and the second medical examination, in IPSS, NIH-CPSI scores and statistically significant increase in IIEF-5 score. In addition, there is no sta- tistically significant difference, in all scores, between mono and combination therapy. Conclusions: tamsulosin monotherapy, as well as a combination therapy (tamsulosin plus silde-nafil) has an improving effect on symptoms and on ED in patients with type III prostatitis. In the near future alpha-blockers monotherapy could be used in the treatment of chronic prostatitis and ED cases instead of phosphodiesterase type 5 (PDE-5) inhibitors combination therapy.
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El-Tatawy, Hassan, Tarek Gameel, Mohammed Abo El-enen, Ayman Hagras, Ayman Mousa, Abdel Hamid El-Bahnasy, Ali Abdel Raheem, and Khaled Abu-dewan. "Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride." Archivio Italiano di Urologia e Andrologia 87, no. 3 (September 30, 2015): 238. http://dx.doi.org/10.4081/aiua.2015.3.238.
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Objectives: To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Materials and methods: A total of 80 patients with LUTS/BPH and with mean age 53.3 ± 6.3 (range 47-70) were included in our prospective comparative study. The patients were classified into 2 groups as a consecutive cases 40 in each one depending on the PUA either ≤ 35° (group A) or > 35° (group B). PUA and different prostatic parameters were measured using transrectal ultrasound. Prostate-specific antigen (PSA), the International Prostate Symptom Score and quality of life score (IPSS/QoL score), maximum flow rate (Q<sub>max</sub>), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of PUA was evaluated after 8 weeks of medical treatment with tamsulosin hydrochloride 0.4 mg daily. Results: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, PSA, IPSS/QoL score, Qmax and PVR volume (P-value > 0.05). Comparison of parameters after 8 weeks showed that tamsulosin hydrochloride improved the total IPSS and all subscores (P < 0.001), QoL (P = 0.001), Q<sub>max</sub> (P = 0.002), and PVR (P = 0.04) in group A (Table 1). Conclusion: Tamsulosin hydrochloride appears to be less effective in improving IPSS/Qol score, Qmax and PVR in patients with lager PUA. The PUA might be a predictor for the treatment efficacy of α-blockers and more studies are warranted in the future before the final conclusion.
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Zaninoni, Anna, Bruno Fattizzo, Juri Alessandro Giannotta, Elisa Fermo, Nicola Cecchi, Paola Bianchi, and Wilma Barcellini. "Single Nucleotide Polymorphisms of Cytokine Genes in Warm Autoimmune Hemolytic Anemias: Relationship with Clinical and Hematological Parameters." Blood 138, Supplement 1 (November 5, 2021): 4142. http://dx.doi.org/10.1182/blood-2021-146006.
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Abstract Background: Autoimmune hemolytic anemia (AIHA) is due to an increased immune peripheral destruction of red blood cells. The disease is characterized by high heterogeneity regarding anemia severity, treatment requirement and occurrence of complications. It has been shown that Hb levels at baseline, presence of complement activation, and the degree of bone marrow compensation are the main predictors of outcome. Moreover, multi-relapsing cases show bone marrow dysmyelopoiesis, and fibrosis suggesting an immune attack against bone marrow precursors. An interesting area to investigate is the genetic landscape of AIHA, including cytokine gene signature and other molecular mechanisms of refractoriness. Aim: To evaluate the frequency of cytokine single nucleotide polymorphisms (SNPs) in warm AIHA and their correlation with clinical and hematological parameters, including the degree of anemia, treatment refractoriness and number of therapies lines. Methods: We investigated SNPs of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 72 Italian warm AIHA patients, using the Cytokine Tray (One Lambda, Canoga Park, CA) according to the manufacturer's recommendations. Allele and genotype frequency results were compared to those described in the Italian population by Uboldi de Capei et al. (2003) and Poli et al. (2002). Results: Seventy-two warm AIHA patients have been evaluated: median age 63 years (range 17-90), classified as per DAT positivity in IgG+ (N=48), IgG+C (N=17), IgA+ (N=1), and DAT negative AIHA (N=6). Demographic and hematological characteristics of patients are described in Figure 1A. Regarding cytokine SNP frequencies, we observed that AIHA patients had a significantly higher prevalence of the TNF-alpha-308 high producers genotypes (G/G and G/A) compared to controls (40.3% vs 16% or 23%, p=0.0003 and p=0.006, respectively). No differences were detected regarding genotype frequencies of the other cytokine SNPs (Figure 1B). By dividing patients according to anemia severity at onset, a more frequent low producer genotype of IFN-gamma (A/A) was observed in patients with Hb levels >7.4 g/dL (median value of patients cohort) compared to the other group (p=0.05). Finally, considering the number of relapses or therapy lines, an increased frequency of TNF-alpha -308 high producers genotypes were found among multi-relapsing (> 3 relapses, 70.5% vs 56%) and multi-treated patients (> 3therapy lines, 52% vs 35%), although not significantly. Conclusions: These preliminary data show that wAIHA patients display a more pro-inflammatory cytokine signature at molecular level as compared to the Italian control population. This is highlighted by an increased prevalence of TNF-alpha high producer genotype that is also associated with multiple relapses and greater treatment requirement. Additionally, cytokine SNPs may be also associated with anemia severity at onset, as observed for IFN-gamma low producer genotype that was more frequent in less severe cases. Figure 1 Figure 1. Disclosures Fattizzo: Alexion, Amgen, Annexon, Apellis, Grifols, Novartis, Momenta: Consultancy, Speakers Bureau. Bianchi: Agios pharmaceutics: Consultancy, Membership on an entity's Board of Directors or advisory committees. Barcellini: Agios: Honoraria, Research Funding; Bioverativ: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria; Alexion Pharmaceuticals: Honoraria; Incyte: Membership on an entity's Board of Directors or advisory committees.
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Maurizi, Angela, Francesco De Luca, Antonino Zanghi, Emy Manzi, Costantino Leonardo, Michele Guidotti, F. P. Antonaccio, Valerio Olivieri, and Carlo De Dominicis. "The role of nutraceutical medications in men with non bacterial chronic prostatitis and chronic pelvic pain syndrome: A prospective non blinded study utilizing flower pollen extracts versus bioflavonoids." Archivio Italiano di Urologia e Andrologia 90, no. 4 (January 18, 2019): 260–64. http://dx.doi.org/10.4081/aiua.2018.4.260.
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Introduction: Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) represents a challenge for the urologist, since the therapeutic efficacy does not always result in a satisfactory quality of life for the patients. Often the side effects of the medications used (antiinflammatories, antibiotics, alpha blockers) far outweighs the benefits gained with their admission. The choice of nutraceutical medications is preferred for their effectiveness, that has been accepted and proven by the scientific community, and for the low incidence of side effects. The objective of this study to compare the therapeutic efficacy of the flower pollen extracts (Deprox®) versus Bioflavonoids in terms of reduction of symptoms, and in the average waiting time of the variation of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI), and to evaluate the quality of life improvement of the patients affected by CP/CPPS. Methods: Among the 68 patients presented with prostatic symptoms to the Hospital “Umberto I” in Rome, Italy between March 2016 and June 2016, 54 patients met the clinical diagnosis of CP/CPPS (class IIIa or IIIb according to the NIH classification). The patients were assigned to either treatment with Deprox® or quercetin based on a randomization scheme previously determined.The NIH- CPSI, IPSS, QoL questionnaires were administered. Every patient underwent bacterial cultures and trans-rectal ultrasound. Results: There was a statistically significant improvement of the NIH-CPSI score and QoL in the Deprox® group (p = < 0.0001 and p = 0.003 respectively). The average waiting time of the variation of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was statistically significant (p = 0.0019). In the absence of efficacy of the “conventional” medications, which also carries significant side effects, the dietary supplements may represent a valid alternative. Conclusions: DEPROX® has demonstrated a significant improvement of the symptoms and quality of life of patients diagnosed with by CP/CPPS. Furthermore, there was a statistical difference in the average waiting time of the variation of the NIH-CPSI) score without side effects as compared to the bioflavonoids complex with quercetin.
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Schädel, Matthias, and Yuichiro Nagame. "From SRAFAP to ARCA and AIDA – developments and implementation of automated aqueous-phase rapid chemistry apparatuses for heavy actinides and transactinides." Radiochimica Acta 107, no. 7 (July 26, 2019): 561–85. http://dx.doi.org/10.1515/ract-2019-3103.
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Abstract The development of automated rapid chemistry techniques and their application for batch-wise, chromatographic separations of heavy elements in the liquid-phase are outlined. Starting in the mid-1970s with manually performed separations using pressurized liquid-chromatography techniques, this development led to the first version of the Automated Rapid Chemistry Apparatus, ARCA, in the early 1980s. After a breakthrough to a much higher level of automation and miniaturization, the new apparatus ARCA II was built in the late 1980s. Based on it, the Automated Ion-exchange separation apparatus coupled with the Detection system for Alpha spectroscopy, AIDA, became operational in the late 1990s. In the context of technical and technological advancements, this article discusses the successful application of these instruments for (i) the search for superheavy elements, (ii) cross section measurements of actinide elements produced in multi-nucleon transfer reactions with actinide targets, (iii) chemical separation and characterization of the heavy actinides mendelevium, Md, and lawrencium, Lr, and (iv) studies of the transactinide elements rutherfordium, Rf, dubnium, Db, and seaborgium, Sg. Details of the separations are outlined together with the big advancements made over time and the limitations reached. For the transactinide elements, examples are given for their observed chemical behavior; often affected by an interplay between hydrolysis and complex formation. Influenced by relativistic effects, chemical properties of these elements sometimes deviated from those of their lighter homologs in the Periodic Table.
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Catanzariti, Francesco, Lucilla Servi, Andrea Fabiani, Alessandra Filosa, and Gabriele Mammana. "Adenomatous hyperplasia of the rete testis: A rare intrascrotal lesion managed with limited testicular excision." Archivio Italiano di Urologia e Andrologia 88, no. 3 (October 5, 2016): 243. http://dx.doi.org/10.4081/aiua.2016.3.243.
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Introduction: Testicular cancer is one of the most frequent in young men and its incidence is increasing in recent years because of incidental finding during routine ultrasound exams. Adenomatous hyperplasia of the rete testis is one of the benign and rare pathological types incidentally detected and very few cases are described in the literature. Case report: A 40 years old man come to our attention for a balanoposthitis without testicular pain. During andrological examination we performed palpation of the testes and we noticed a palpable nodule of hard consistency in the left testicle. We then performed an ultrasound exam of the testis which highlighted the presence of an intra-didymus neoformation with diameters of 1.2 x 1.6 cm and with the presence of cysts inside. We also performed blood tests to check tumor markers alpha fetoprotein, beta hCG and LDH which resulted inside the normal range. We then conducted a chest and abdomen CT scan that showed no pathological elements. Therefore, as we suspected that this tumor was benign, we performed an enucleation of the neoplasm. The definitive histological examination revealed the presence of dilated ducts lined with epithelial cubic-columnar cells with clear cytoplasm rich in glycogen and the pathologist so concluded that the tumor could be classified as adenomatous hyperplasia of the rete testis. At three months of follow up, the patient doesn’t have any recurrent lesion to either testicles. Discussion: Adenomatous hyperplasia of the rete testis is a very rare intrascrotal lesion. This histological type is the most frequent between benign lesion of the ovary, but few works in literature reported this histological type in the male gonad and, in most of these works, authors described these lesion at epididymis. Conclusion: We believe that a conservative approach must be considered mandatory in case of testicular lesions 1.5 cm in diameter. A radical approach might have alterate fertility of the patient and also have caused psychological trauma more than an enucleation. However a longer follow up is needed to understand if this was the right decision for the oncological point of view.
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Piveta, Maíra Nunes, Flavia Luciane Scherer, Maríndia Brachak Dos Santos, and Fabrício Nunes Gomes. "Análise da satisfação dos consumidores finais: um estudo em uma empresa do setor de Vending Machines na cidade de Santa Maria – RS." Revista Científica Hermes - FIPEN 15 (June 1, 2016): 173. http://dx.doi.org/10.21710/rch.v15i0.259.
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As organizações estão inseridas em um ambiente concorrencial globalizado que sofre transformações e avanços constantemente. Atentas a essas modificações que acompanham as descobertas tecnológicas, as empresas precisam estar a todo o tempo buscando criar diferenciais competitivos. Diante deste cenário, a empresa Alpha, que comercializa máquinas automáticas de café e insumos para as mesmas, adotou como estratégia aproximar-se dos seus consumidores finais, aqueles que adquirem as bebidas Alpha nos pontos de venda. Desse modo, o objetivo geral deste trabalho foi identificar e avaliar o grau de satisfação dos consumidores finais da empresa Alpha no que tange aos produtos e bebidas e marketing digital nas mídias sociais. A pesquisa pode ser classificada como descritiva quanto à natureza com abordagem quantitativa por intermédio da aplicação de um instrumento de pesquisa junto a uma amostra de cento e vinte consumidores finais da empresa Alpha diretamente nos pontos de venda delimitados. Os resultados da pesquisa indicaram que, de maneira geral, a satisfação dos consumidores finais quanto aos produtos Alpha é grande, exceto no que se refere aos fatores preço e quantidade de açúcar. Ainda, observou-se que o alcance das ações de marketing digital da Alpha é baixo, sendo evidenciado através de baixos graus de satisfação justificados pela falta de conhecimento dos consumidores para com as mídias sociais utilizadas pela empresa. Por fim, oportunidades e sugestões de melhorias foram apresentadas.
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Fabiani, Andrea, Lucilla Servi, Alessandra Filosa, Fabrizio Fioretti, Valentina Maurelli, Flavia Tombolini, Matteo Tallè, and Gabriele Mammana. "May ultrasound probe size influence pain perception of needle piercing during transrectal prostate biopsy? A prospective evaluation." Archivio Italiano di Urologia e Andrologia 88, no. 3 (October 5, 2016): 223. http://dx.doi.org/10.4081/aiua.2016.3.223.
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Introduction and Objective: Transrectal ultrasound guided prostate biopsy (TRUS-Bx) is the definitive step in the diagnosis of prostate cancer (CaP). Patients (pts) generally experience significant pain during the procedure at the point that biopsy should be accompanied by some form of anesthesia. Several different factors influence pain perception (PP) during TRUS-Bx. In our study we want to assess that the use of an ergonomic smaller sized probe reduces PP during the procedure independently from the administration of local anesthesia or pain relieving drugs. Materials and Methods: This was a prospective, randomized study in which 114 pts who underwent TRUS-Bx due to abnormal PSA and/or to digital rectal examination (DRE) suspicious findings were considered eligible. Pts were split in two TRUS-Bx groups into which we used two different sized ultrasound probes. In group 1, 61 pts underwent TRUS-Bx with ALOKA end fire probe (size 74 mm). In group 2, 53 pts underwent TRUS-Bx with B-K Type 8818 probe (size 58 mm). Both groups were treated with no local anesthesia or pain relieving drugs. Pain was evaluated three times using a 10-point visual analogue scale (VAS), during the DRE (VAS 1), during the insertion of the probe (VAS 2) and during the needle piercing (VAS 3). Results: Mean age of pts was 68.03 (SD 8.51); mean tPSA and mean prostate volume was 7.75 (SD 4.83) and 45.17cc (SD 17.7), respectively. The two groups were homogeneous respect to tPSA (p = 0.675) and to prostate volume (p = 0.296); age was significantly different (p = 0.04) between Group 1 (65.93) and Group 2 (70.43), whereas no statistically significant correlation between VAS 3 and age was observed (p = 0.179). Analyzing pain perception, we found no statistically significant difference between the two groups in DRE (VAS 1; p = 0.839); on the contrary, patients in Group 1 experienced on average more pain than other in Group 2 both during the insertion of the probe (VAS 2 3.49 vs 1.09; p < 0.001) and during the needle piercing VAS 3 (2.8 vs 2.00; p < 0.05). The discomfort during probe insertion and manipulation was perceived as very high (VAS 2 > 5) in 42.6% of patients in Group 1 and in 9.4% in Group 2. Globally, the procedure was well tolerated (mean VAS score < 3) in 77% of patients in Group 1 and in 90% in Group 2. The proportion of patients who experienced more than moderate pain (VAS > 5) during needle piercing ranged 24.6 % in Group 1 to 18.9 % in Group 2. Conclusions: Patients who underwent a TRUS-Bx with the 58-mm circumference probe were found to experience lower degree of pain not only during the insertion of the probe through the anal sphincter, but also in the moment of needle piercing.
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Diserbo, Michel, Arnaud Agin, Ioannis Lamproglou, Jérôme Mauris, Fatiha Staali, Eric Multon, and Christine Amourette. "Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study." Canadian Journal of Physiology and Pharmacology 80, no. 7 (July 1, 2002): 670–78. http://dx.doi.org/10.1139/y02-070.
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The effects of total-body irradiation on the permeability of rat striatal blood-brain barrier (BBB) to [3H]alpha-aminoisobutyric acid (AIBA) and [14C]sucrose were investigated using the microdialysis technique. Seven days, 3 and 6 weeks, and 3, 5, and 8 months after gamma exposure at a dose of 4.5 Gy, no modification of the permeability to both [3H]AIBA and [14C]sucrose was observed. But, in the course of the initial syndrome, we observed a significant but transient increase in the BBB permeability to the two markers between 3 and 17 h after exposure. A secondary transient "opening" of the BBB to [14C]sucrose was noticed about 28 h following irradiation without the corresponding increase in BBB permeability to [3H]AIBA. On the contrary, the transport of [3H]AIBA through the BBB was decreased between 33 and 47 h postradiation. In conclusion, our experiments showed early modifications of BBB permeability after a moderate-dose whole-body exposure. Confirmation of these results with other tracers, in another experimental model or in humans, would have clinical applications for designing appropriate pharmacotherapy in radiotherapy and treatment of accidental overexposure.Key words: radiation effects, central nervous system, blood-brain barrier, moderate dose, microdialysis.
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Gómez-Guerrero, C., N. Duque, and J. Egido. "Stimulation of Fc(alpha) receptors induces tyrosine phosphorylation of phospholipase C-gamma(1), phosphatidylinositol phosphate hydrolysis, and Ca2+ mobilization in rat and human mesangial cells." Journal of Immunology 156, no. 11 (June 1, 1996): 4369–76. http://dx.doi.org/10.4049/jimmunol.156.11.4369.
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Abstract Although knowledge of IgA Fc receptor (Fc(alpha)R) structure and gene organization has progressed in the past few years, signal transduction pathways elicited by its activation have hardly been studied. Previously, we have demonstrated that mesangial cells (MC) possess Fc(alpha)R stimulation triggers several biologic responses. In this work, we studied the early biochemical signals triggered by Fc(alpha)R stimulation in MC. MC incubation with aggregated IgA (AIgA) elicited a dose-dependent increase in cytosolic Ca2+ ([Ca2+]i). The response was rapid and transient, and slowly fell to the original baseline. Ca2+ mobilization was dependent on the Fc region of the IgA, because Fc, but neither Fab fragment nor carbohydrates, inhibited the [Ca2+] rise. The initial induction of [Ca2+]i rise was due to Ca2+ mobilization from inositol trisphosphate (IP3)-sensitive intracellular stores, while sustained levels were maintained through extracellular Ca2+ influx. Stimulation of Fc(alpha)R also resulted in production of IP3, temporally correlated with Ca2+ mobilization. Protein tyrosine kinase inhibitors abolished [Ca2+]i rise, indicating that tyrosine phosphorylation of some substrates is required for Ca2+ mobilization. Stimulation through Fc(alpha)R gave rise to a marked increase in tyrosine phosphorylation of several proteins, including the 147-kDa band, similar in size to phospholipase C-gamma(1) (PLC-gamma(1)). Tyrosine phosphorylation of PLC-gamma(1) reached a maximum 30 s after stimulation, as determined by immunoprecipitation and Western blot. Collectively, these results indicate that the Fc(alpha)R signaling pathway in MC involves PLC-(gamma(1) activation, IP3 formation, and Ca2+ mobilization, and is linked to activation of tyrosine kinases.
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Miranda, Rogério Henrique, and Clodis Boscarioli. "Utilização de metodologia multicritério para identificação de vetores concorrentes ao fomento de uma cultura de inovação organizacional." Revista Mosaicos: Estudos em Governança, Sustentabilidade e Inovação 2, no. 1 (December 17, 2020): 55–71. http://dx.doi.org/10.37032/remos.v2i1.47.
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A estrutura de poder da empresa denominada aqui de Alpha[1] é igualitária entre os dois países sócios; consequentemente, o processo decisório é binacional. Entretanto, inexiste na sua estrutura organizacional uma área responsável por pesquisa e desenvolvimento e, ademais, a melhoria de seus processos de trabalho ocorre de maneira quase empírica, sem muitas iniciativas formais para construir uma cultura de inovação. Este trabalho buscou identificar os vetores que concorrem para a criação de uma cultura de inovação corporativa por meio da metodologia multicritério de apoio à decisão e verificar a sua presença na Alpha. Realizou-se também pesquisa bibliográfica e pesquisa entre os empregados da empresa a fim de construir um referencial teórico que alicerçasse e validasse os vetores revelados pela metodologia multicritério, que foram: clima organizacional propício, educação corporativa voltada para a inovação, parcerias estratégicas e o estabelecimento de um prêmio corporativo de reconhecimento e recompensa. Os principais resultados alcançados denotam que existem na empresa Alpha iniciativas esparsas de desenvolvimento desses vetores, porém, ainda sem sinergia entre eles e sem a estruturação necessária para o estabelecimento de uma cultura de inovação efetiva na organização.
[1] Nome fictício adotado para se referir à organização alvo da pesquisa.
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Aguiar, Odaleia Barbosa de, Maria de Jesus Mendes da Fonseca, and Joaquim Gonçalves Valente. "Confiabilidade (teste-reteste) da escala sueca do Questionário Demanda-Controle entre Trabalhadores de Restaurantes Industriais do Estado do Rio de Janeiro." Revista Brasileira de Epidemiologia 13, no. 2 (June 2010): 212–22. http://dx.doi.org/10.1590/s1415-790x2010000200004.
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OBJETIVO: Este estudo tem o objetivo de verificar a confiabilidade teste-reteste da versão em Português da escala sueca "Demand-Control-Support Questionnaire (DCSQ)" em uma população de trabalhadores com baixa escolaridade. MÉTODO: O questionário foi aplicado em dois momentos para 52 trabalhadores de três restaurantes industriais de uma empresa concessionária do Rio de Janeiro, com intervalos de 7 a 15 dias. Como indicadores de estabilidade foram utilizados o Coeficiente de Correlação Intraclasse (CCIC), a estatística Kappa Ponderado e o gráfico de Bland & Altman. Para avaliação da consistência interna utilizou-se o Coeficiente Alpha de Cronbach. RESULTADOS: O CCIC para as dimensões: demanda psicológica, controle do trabalho e apoio social no trabalho foi de 0,70, 0,68 e 0,80, respectivamente. O Alpha de Cronbach apresentou, no reteste, os seguintes resultados: 0,75, 0,50 e 0,82, para as dimensões anteriormente citadas, na mesma sequência. CONCLUSÕES: Ainda que o resultado da escala controle do trabalho tenha sido considerado baixo para o Alpha de Cronbach, os outros indicadores de confiabilidade apontam para uma boa estabilidade do instrumento, possibilitando sua utilização em estudos de associação entre estresse no trabalho e desfechos relacionados à saúde.
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Coelho, Pedro. "Aliança Estratégica entre Academia e Jornalismo uma discussão em marcha no Labform." Media & Jornalismo 16, no. 28 (September 7, 2016): 25–38. http://dx.doi.org/10.14195/2183-5462_28_1.
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Este artigo parte do debate vivo que se aloja no espaço virtual, acondicionadonum blog dedicado à formação académica em jornalismo. A partir dessa discussão levantamos as grandes questões associadas ao percurso ideal para se chegar a uma das mais complexas profissões da humanidade, trespassada, por um lado, pela crise de sustentabilidade do jornalismo, ampliada pelos efeitos da tecnologia digital, por outro, pela indefinição da própria academia. A comunicação adquiriu o estatuto de disciplina académica há quase quatro décadas, mas o jornalismo, uma das áreas nobres do campo, ainda tarda em encontrar um lugar de acolhimento.
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Specchia, Giorgina, Francesco Lo Coco, Marco Vignetti, Giuseppe Avvisati, Paola Fazi, Francesco Albano, Francesco Di Raimondo, et al. "Extramedullary Involvement at Relapse in Acute Promyelocytic Leukemia Patients Treated or Not With All-Trans Retinoic Acid: A Report by the Gruppo Italiano Malattie Ematologiche dell’Adulto." Journal of Clinical Oncology 19, no. 20 (October 15, 2001): 4023–28. http://dx.doi.org/10.1200/jco.2001.19.20.4023.
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PURPOSE: Recent reports of extramedullary disease (EMD) at recurrence in acute promyelocytic leukemia (APL) have raised increasing concern about a possible role of retinoic acid (RA) therapy. PATIENTS AND METHODS: We analyzed the risk of developing EMD localization at relapse in APL patients enrolled onto two consecutive studies of the Gruppo Italiano Malattie Ematologiche dell’Adulto. The studies investigated chemotherapy alone (LAP0389) versus RA plus chemotherapy (AIDA). RESULTS: When all relapse types were taken into account, 94 (51%) of 184 patients and 131 (18%) of 740 patients who attained hematologic remission underwent relapse in the LAP0389 and AIDA studies, respectively (P < .0001). EMD localization was documented in five (5%) of 94 and 16 (12%) of 131 patients (P = .08). Hematologic and/or molecular relapse was diagnosed concomitantly in all but two patients with EMD in the AIDA study. For patients in the LAP0389 and AIDA series, the probability of EMD localization of any type at relapse was 3% and 4.5%, respectively (P = .79), while the probability of CNS involvement was 0.6% and 2% (P = .28). No significant differences were found with regard to mean WBC count and promyelocytic leukemia/retinoic acid receptor-alpha junction type in comparisons of patients with EMD and hematologic relapse. CONCLUSION: APL patients receiving all-trans retinoic acid in addition to chemotherapy have no increased risk of developing EMD at relapse as compared with those treated with chemotherapy alone.
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Luz, Ana Claudia da, Adriane Fabricio, Nairana Radtke Caneppele Bussler, and Luis Felipe Dias Lopes. "Florescimento e engajamento no trabalho: um estudo sob a visão da equipe do hospital Alpha." Research, Society and Development 9, no. 7 (May 30, 2020): e560974447. http://dx.doi.org/10.33448/rsd-v9i7.4447.
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O objetivo deste estudo foi identificar se há relação entre o engajamento e o florescimento no trabalho dos funcionários do Hospital Alpha localizado na Região Noroeste do Estado do Rio Grande do Sul. Considera-se como florescimento o indivíduo que se encontra em uma situação de prosperidade, de desenvolvimento, um estado progressivo de satisfação e bem-estar no trabalho, já o engajamento no trabalho remete à uma situação de satisfação com as atividades realizadas. Estes temas ainda são pouco explorados em conjunto, mas são relevantes no contexto do trabalho. Realizamos um levantamento (Survey) com a equipe do Hospital Alpha. A coleta de dados foi realizada utilizando um instrumento de pesquisa que se dividiu em três partes. A análise e interpretação dos dados foi realizada utilizando o Software SPSS®. A amostra foi enquadrada como florescida, não evidenciando nenhum índice de baixo florescimento, apenas de médio e alto. No aspecto engajamento no trabalho apenas a dimensão absorção apresentou baixo índice. De maneira geral, os profissionais do Hospital Alpha possuem níveis de médio e alto engajamento. Essa nova forma de analisar os indivíduos e o ambiente organizacional, denominada de engajamento e florescimento pode ser utilizada como uma estratégia da organização para realização de atividades nas diferentes áreas das organizações.
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Ito, Kenichi, Yoshihito Uchino, Kazuhiko Hirano, and Naohiro Sekiguchi. "Other iatrogenic immunodeficiency lymphoproliferative disorder induced by corticosteroid used for an autoimmune disorder." Journal of International Medical Research 50, no. 12 (December 2022): 030006052211441. http://dx.doi.org/10.1177/03000605221144149.
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Other iatrogenic immunodeficiency lymphoproliferative disorders (oii-LPD) are defined as lymphoid proliferations or lymphomas that occur in patients taking immunosuppressive agents (ISA) for autoimmune disorders (AID). Although methotrexate and tumor necrosis factor-alpha inhibitors cause oii-LPD, the association between corticosteroids and lymphomagenesis remains unknown. Herein, we present the case of a 51-year-old woman with oii-LPD caused by corticosteroid use for autoimmune hemolytic anemia (AIHA). The diagnosis of AIHA was made in May 2016, and AIHA had been well-controlled for 5 years with oral prednisolone (PSL). During a regular follow-up visit in March 2022, an abnormal increase in atypical lymphoid cells in the peripheral blood was found. The bone marrow biopsy specimens showed local aggregations of large cells that were identified as lymphoplasmacytic cells and plasma cells, and that were positive for cluster of differentiation (CD)19 and CD20, with apparent nucleoli among the diffuse infiltration of atypical small lymphocytes. The large cells were partially positive for the Epstein–Barr encoding region in situ hybridization and latent membrane protein 1, which confirmed Epstein–Barr virus (EBV)-affected lymphomagenesis. To our knowledge, this is the first report of an oii-LPD case shown to be induced by corticosteroid use for AID.
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Fattizzo, Bruno, Matteo Claudio Da Via', Juri Alessandro Giannotta, Paola Bianchi, Luca Baldini, Niccolo Bolli, and Wilma Barcellini. "Dissection of Bone Marrow Microenvironment By Single Cell RNA Sequencing in Warm AIHA Patients: A Proof-of-Concept Analysis." Blood 138, Supplement 1 (November 5, 2021): 931. http://dx.doi.org/10.1182/blood-2021-149546.
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Abstract Warm type autoimmune hemolytic anemia (wAIHA) is a rare disease characterized by variable severity and bone marrow (BM) compensation, unpredictable relapses and several complications (i.e. infections and thrombosis). Most therapies are aimed at restoring immune tolerance by targeting various immunologic mechanisms (autoantibody production, reticuloendothelial phagocytosis, and complement activation). BM composition during acute and chronic/relapsing disease phases is still under investigated, and preliminary studies showed that it may predict anemia severity and treatment response. We aimed at dissecting BM environment by single cell RNA sequencing (scRNA-seq) in patients with wAIHA. We selected 2 patients experiencing mild hemolytic reactivations handled with low dose steroids (M-AIHA) and 2 with severe relapses requiring high steroid doses and rituximab (S-AIHA). We focused on lymphoid/myeloid subpopulations and their gene expression and evaluated the association of output data with clinical features. We performed scRNA-seq for 17,989 single cells, detecting over 23,446 expressed genes per cell on average. Uniform manifold approximation and projection (UMAP), a method for nonlinear dimensionality reduction, showed the microenvironmental cell composition, including T-, B- and NK- lymphocytes and their subpopulations, plasma cells, CD14+ and CD16+ monocytes, hematopoietic stem cells, and myeloid precursors (Figure 1A). On the whole, BM microenvironment showed a high frequency of innate immunity effectors such as NK cells and monocytes (11% and 15% of total cells), likely reflecting the inflammatory state typical of autoimmune/autoinflammatory response. T-cell subpopulations were also highly represented. Specifically, more CD4+ memory than CD4+ naïve T-cells (58% vs 38%) were found, and T-regs represented a small fraction (4%). Also, CD8+ memory cells were more frequent than CD8+ naïve and CD8+ effectors (55% vs 24% vs 21%). Both CD8+ memory and effectors type 2 cells were higher than type 1 cells, indicating a likely participation of T cell compartment in disease phenotype. Finally, B cells were particularly underrepresented, probably due to recent therapy (steroids/rituximab). Figure 1B displays % of BM immune cells divided into M-AIHA and S-AIHA. S-AIHA patients showed higher CD14+ monocytes (57% vs 43%) and decreased NK cells (19% vs 81%) as compared to M-AIHA. Interestingly, within the latter compartment, the CD56 bright NKs were over-represented in S-AIHA (83% vs 17%), suggesting an attempt to negatively regulate activated lymphocytes. Moreover, S-AIHA showed a severe decrease of B cells as compared to M-AIHA, consistently with more recent rituximab treatment. Furthermore, we performed differential expression and gene set enrichment (GSEA) analysis within the different cell subset comparing M-AIHA and S-AIHA. Concerning T cells, we found differential expression of genes related to T-cell receptor, immunoglobulins and interferon alpha/gamma response. Regarding CD14+ monocytes, we observed a downregulation of pathways related to immunomodulatory/inflammatory cytokines, complement activation and apoptosis in S-AIHA versus M-AIHA. Finally, using the CopyKat tool, we found aneuploidies in myeloid cells, including stem cells, suggesting that the selective pressure from the immune environment may lead to accumulation of genetic lesions in chronic S-AIHA. This clonal evolution can possibly explain the clinical overlap with myeloid neoplasms. Overall, these preliminary data show for the first time that scRNA-seq technology is feasible in wAIHA patients and gives insights in the pathogenic role of bone marrow immunologic microenvironment. Additionally, BM composition appears to dynamically modify according to disease severity and treatment, potentially enabling tailored therapies. Figure 1 Figure 1. Disclosures Fattizzo: Kira: Speakers Bureau; Alexion: Speakers Bureau; Novartis: Speakers Bureau; Momenta: Honoraria, Speakers Bureau; Annexon: Consultancy; Apellis: Speakers Bureau; Amgen: Honoraria, Speakers Bureau. Bianchi: Agios pharmaceutics: Consultancy, Membership on an entity's Board of Directors or advisory committees. Bolli: Celgene/BMS: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Honoraria; Amgen: Honoraria. Barcellini: Alexion Pharmaceuticals: Honoraria; Incyte: Membership on an entity's Board of Directors or advisory committees; Agios: Honoraria, Research Funding; Bioverativ: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria.
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Jarie, Laurane, Carlos Salavera Bordás, Abel Merino Orozco, and Pablo Usán Supervía. "Validación y Confiabilidad de la versión francesa de la escala de ansiedad lingüística "Foreign Language Classroom Anxiety Scale" y aplicado a estudiantes franceses: Revisión del análisis de Horwitz y Cope, Aida y Pérez y Martínez." Thélème. Revista Complutense de Estudios Franceses 34, no. 1 (June 5, 2019): 207–25. http://dx.doi.org/10.5209/thel.61553.
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La ansiedad ante el aprendizaje de las lenguas extranjeras es una de las variables más influyentes en el aprendizaje de idiomas extranjeros. Horwitz y Cope (1986, 1991) desarrollaron un marco teórico alrededor del constructo específico de ansiedad lingüística que consigue explicar el rol de esta variable dentro del proceso de enseñanza – aprendizaje de las lenguas extranjeras. Los autores elaboraron una escala estadísticamente fiable y válida para poder medir los niveles de ansiedad lingüística. La presente investigación pretende estudiar la validación y la confiabilidad del instrumento Foreign Language Classroom Anxiety Scale traducido al idioma francés para su aplicación con estudiantes franceses de secundaria así como repetir el análisis factorial de la FLCAS realizado por Aida (1994), Pérez y Martínez (2001). La adaptación del instrumento, se distribuye, tras el análisis con rotación Varimax, en cuatro factores que explican el 58,78% de la varianza total y un alpha de Cronbach de ,77.
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Jorge, Diana Filipa Oliveira, Graça Esgalhado, and Henrique Pereira. "Inteligência Espiritual: Propriedades psicométricas da Escala de Inteligência Espiritual Integrada (EIEI)." Análise Psicológica 34, no. 3 (September 12, 2016): 325–37. http://dx.doi.org/10.14417/ap.982.
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Objetivo: Amram e Dryer (2008) propõem uma visão da Inteligência Espiritual que pode ser englobada na Teoria das Múltiplas Inteligências de Gardner e que compreende os domínios «Consciência», «Transcendência», «Graça», «Verdade» e «Significado», criando assim a Integrated Spiritual Inteligence Scale [ISIS]. Deste modo, a presente investigação pretendeu estudar as propriedades psicométricas da versão portuguesa da referida escala. Método: Participaram no estudo 714 sujeitos, 257 do sexo masculino e 461 do sexo feminino, com idades compreendidas entre os 14 e os 81 anos. A aplicação dos instrumentos realizou-se online e além da utilização da Escala de Inteligência Espiritual Integrada usámos um questionário sociodemográfico com o intuito de caracterizar a amostra. Resultados: Os resultados indicam uma estrutura penta fatorial («Coping Religioso e Espiritual», «Consciência», «Graça», «Significado» e «Missão») com valores de alpha de Cronbach situados entre os 0.67 e 0.88. O valor de alpha de Cronbach total da escala é de 0.92. Conclusões: A escala apresenta bons indicadores de fiabilidade, sensibilidade e validade de constructo, ainda que os valores obtidos não tenham sido congruentes com a escala original.
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Lima, Yarly Queiroz de, and Luiz Flávio Autran Monteiro Gomes. "Identificação e valoração dos critérios de decisão em projetos de descomissionamento offshore." Revista de Gestão e Projetos 12, no. 2 (June 15, 2021): 9–27. http://dx.doi.org/10.5585/gep.v12i2.19781.
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O cenário de volatilidade de preços do barril de petróleo causado pela pandemia COVID-19 ainda não é totalmente conhecido por ainda estarmos vivenciando os impactos da abrupta alteração da demanda. Entre os inúmeros impactos, fatores macro e microeconômicos podem antecipar o processo de descomissionamento de unidades de exploração e produção de petróleo e gás natural. O objetivo deste estudo foi explorar a ordem de preferências de critérios e subcritérios aplicáveis a métodos de Apoio Multicritério à Decisão na seleção de alternativas de descomissionamento de unidades marítimas de exploração e produção de petróleo e gás natural. Para alcançar o objetivo proposto realizou-se pesquisa de campo com membros de equipe de projetos de descomissionamento. Aplicou-se os resultados de preferência entre critérios e subcritérios no descomissionamento da plataforma Alpha Jacket do campo de Brent. Constatou-se o alinhamento das preferências a políticas de segurança, preservação da vida e do meio ambiente, aderente aos instrumentos de incentivo de órgãos reguladores, bem como aos valores éticos e pilares estratégicos da empresa em que estão inseridos.
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Carvalho, Mônica Rocha de. "Entre dois BRICs." GV-executivo 6, no. 5 (October 3, 2007): 17. http://dx.doi.org/10.12660/gvexec.v6n5.2007.34685.
Full textAbstract:
<p class="MsoNormal" style="margin-bottom: 0.0001pt;">O espantoso crescimento econômico chinês vem atraindo expressivos volumes de capital para seus mercados. O país vem institucionalizando práticas de governança corporativa ainda que, na prática, a estrutura de propriedade das empresas esbarre na presença maciça do estado controlador. O artigo compara os mercados de capitais de Brasil e China à luz da atratividade desses mercados como opção de alocação de recursos.</p>