Academic literature on the topic 'Allyic substitution'
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Journal articles on the topic "Allyic substitution"
Hastings, Alan. "Substitution Rates Under Stabilizing Selection." Genetics 116, no. 3 (July 1, 1987): 479–86. http://dx.doi.org/10.1093/genetics/116.3.479.
Full textVilotijevic, Ivan, Markus Lange, and You Zi. "Latent (Pro)Nucleophiles in Enantioselective Lewis Base Catalyzed Allylic Substitutions." Synlett 31, no. 13 (June 4, 2020): 1237–43. http://dx.doi.org/10.1055/s-0040-1707130.
Full textLopes Jesus, A. J., Cláudio M. Nunes, Gil A. Ferreira, Kiarash Keyvan, and R. Fausto. "Photochemical Generation and Characterization of C-Aminophenyl-Nitrilimines: Insights on Their Bond-Shift Isomers by Matrix-Isolation IR Spectroscopy and Density Functional Theory Calculations." Molecules 29, no. 15 (July 25, 2024): 3497. http://dx.doi.org/10.3390/molecules29153497.
Full textBergbreiter, David E., Andrew Kippenberger, and Zhenqi Zhong. "Catalysis with palladium colloids supported in poly(acrylic acid)-grafted polyethylene and polystyrene." Canadian Journal of Chemistry 84, no. 10 (October 1, 2006): 1343–50. http://dx.doi.org/10.1139/v06-076.
Full textKang, Suk-Ku, Dae-Yeun Kim, Ryung-Kee Hong, and Pil-Su Ho. "Ruthenium-Catalyzed Allylic Substitution of Allylic Cyclic Carbonates." Synthetic Communications 26, no. 17 (September 1996): 3225–35. http://dx.doi.org/10.1080/00397919608004631.
Full textShekhar, Shashank, Brian Trantow, Andreas Leitner, and John F. Hartwig. "Sequential Catalytic Isomerization and Allylic Substitution. Conversion of Racemic Branched Allylic Carbonates to Enantioenriched Allylic Substitution Products." Journal of the American Chemical Society 128, no. 36 (September 2006): 11770–71. http://dx.doi.org/10.1021/ja0644273.
Full textBoussonnière, Anne, Anne-Sophie Castanet, and Hélène Guyon. "Transition-Metal-Free Enantioselective Reactions of Organomagnesium Reagents Mediated by Chiral Ligands." Synthesis 50, no. 18 (June 20, 2018): 3589–602. http://dx.doi.org/10.1055/s-0037-1610135.
Full textThoke, Mahesh Bhagwan, and Qiang Kang. "Rhodium-Catalyzed Allylation Reactions." Synthesis 51, no. 13 (April 30, 2019): 2585–631. http://dx.doi.org/10.1055/s-0037-1611784.
Full textTakeuchi, Ryo. "Iridium-Catalyzed Enantioselective Allylic Substitution." Journal of Synthetic Organic Chemistry, Japan 74, no. 9 (2016): 885–902. http://dx.doi.org/10.5059/yukigoseikyokaishi.74.885.
Full textAlexakis, A., and C. Falciola. "Copper-Catalyzed Asymmetric Allylic Substitution." Synfacts 2007, no. 7 (July 2007): 0714. http://dx.doi.org/10.1055/s-2007-968661.
Full textDissertations / Theses on the topic "Allyic substitution"
Yu, Xiaodan. "New functionalized alkylidenecyclobutanes : multicomponent synthesis and applications." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF034.
Full textCyclobutane derivatives have become increasingly important as molecular building blocks because of their inherent ring strain that facilitates the selective modification of their structures for strategic used in organic synthesis. Cyclobutane rings also appear in the molecular structures of a wide panel of natural and synthetic molecules that display interesting biological activities. Within this large family, alkylidenecyclobutane subunits are encountered in natural products, such as providencin, and they exhibit enhanced reactivity providing access to complex molecular structures, including enlarged ring and highly functionalized cyclobutane derivatives. In our laboratory, we recently developed an efficient synthesis of functionalized cyclobutenes through a domino photochemical reaction starting from cyclopent-2-enones and ethylene. Based on this study, we first explored a straight-forward transformation of functionalized cyclobutenes into alkylidenecyclobutanes. We then combined both sequences in a domino-multicomponent process. This was accomplished in a single protocol, comprising a tandem photochemical [2+2]-cycloaddition / Norrish-I / γ-H transfer reaction followed by an acetal-protection and an allylic substitution reaction. Additionally, the intramolecular version of these reactions allowed the synthesis of complex fused-bicyclic alkylidenecyclobutanes. Finally, the post-funtionalization of selected alkylidenecyclobutanes was studied, aiming to prepare novel fused tricyclic compounds through a intramolecular [2+2] photochemical process
Xie, Jianing. "Advancing Pd-catalyzed Stereoselective Allylic Substitution Reactions." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670221.
Full textEsta tesis doctoral se centra principalmente en el desarrollo de nuevos métodos catalíticos (dominó) basados en la sustitución alílica catalizada por Pd para la síntesis estereoselectiva de pequeñas moléculas funcionales y heterociclos utilizando un diseño detallado de ligandos y sustratos. Esta tesis está organizada en cinco capítulos: el primer capítulo es una introducción general sobre los aspectos básicos de la química alílica. El segundo capítulo ilustra el primer método general para la preparación de éteres arílicos alílicos terciarios enantioenriquecidos mediante una eterificación regio- y enantio-selectiva catalizada por Pd de los VCCs en presencia de nucleófilos fenólicos. La regioselectividad de la reacción puede ajustarse selectivamente al producto lineal Z cambiando el ligando fosforamidito a un ligando monofosfina, demostrando así el papel crucial del diseño adecuado del ligando. El tercer capítulo describe el diseño de un nuevo alcohol alílico terciario equipado con un grupo carboxilo, que se utiliza en primer lugar para la síntesis de γ-lactamas α,β-insaturadas mediante una aminación alílica estereoselectiva catalizada por Pd, seguido por un proceso de ciclación intramolecular. Los estudios mecanisticos sugieren que el grupo carboxilo es crucial para esta transformación y actúa como un grupo funcional activador y estereodirector. El cuarto capítulo presenta un enfoque estereodivergente controlado por el ligando para la síntesis de γ-aminoácidos con configuración Z o E derivados de alcoholes alílicos terciarios y aminas secundarias. Los resultados experimentales destacan el papel crucial del ligando de soporte y el ángulo de mordedura de la difosfina. El quinto capítulo informa sobre un método general para la síntesis de caprolactamas insaturadas sustituidas a través de un proceso de aminación / ciclación en cascada utilizando vinil γ-lactonas como sustratos mediante el uso de un ligando fosforamidito recientemente desarrollado. Finalmente, se extrae una conclusión general para cada capítulo y también se discute la aplicación potencial de estas metodologías desarrolladas.
This doctoral thesis is mainly focused on the development of novel catalytic (domino) synthesis methods based on Pd-catalyzed allylic substitution for the stereoselective synthesis of functional small molecules and heterocycles utilizing a detailed ligand engineering and substrate design. The scope of this thesis is organized into five chapters: the first chapter is a general introduction on the regular aspects of allylic chemistry. The second chapter illustrates the first general method for the preparation of enantioenriched tertiary allylic aryl ethers through a Pd-catalyzed regio- and enantio-selective etherification of VCCs in the presence of phenolic nucleophiles. The regioselectivity of the reaction can be finely tuned to the Z-selective linear product by switching the phosphoramidite ligand to a monophosphine ligand, thus proving the crucial role of proper ligand engineering. The third chapter describes a newly designed tertiary allylic alcohol equipped with a carboxyl group, which is firstly used for α,β-unsaturated γ-lactams synthesis through Pd-catalyzed stereoselective allylic amination and intramolecular cyclization process. Mechanistic studies suggest that the carboxyl group is crucial for this transformation, and acts as an activating and stereodirecting functional group. The fourth chapter presents a ligand-controlled stereodivergent approach for the synthesis of either Z or E-configured γ-amino acids derived from tertiary allylic alcohols and secondary amines. The experimental results highlight the crucial role of the supporting ligand and the diphosphine bite angle. The fifth chapter reports a general method for substituted unsaturated caprolactam synthesis through a cascade amination/cyclization process using vinyl γ-lactones as substrate by using a newly developed phosphoramidite ligand. Finally, a general conclusion for each chapter is given and potential applications for these developed methodologies are also discussed.
Clizbe, Elizabeth Adair. "Assymmetric transition metal-catalyzed allylic substitution reactions." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539737.
Full textCai, Aijie. "Pd-catalyzed Allylic Substitution for Construction of Quaternary Stereocenters." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668819.
Full textDes del primer treball inicial de Tsuji i Trost, hi ha hagut un ràpid progrés durant les últimes dècades en el desenvolupament de lligands quirals i l'abast de reacció dels electròfils i nucleòfils aplicables en reaccions de substitució al·lílica catalitzades per Pd. A més, s'han utilitzat reaccions de substitució al·lílica asimètriques asimètriques catalitzades per Pd en la síntesi total d'una varietat de molècules quirals complexes, proporcionant una evidència sòlida de la utilitat de la metodologia AAA en el control tant de la regio com de l'enantio-selectivitats. Malgrat els nombrosos avenços ja realitzats, forjar derivats al·lílics ramificats quirals de materials inicials senzills i fàcilment disponibles continua essent una tasca important en la química sintètica, a causa del potencial d’aquests compostos al·lílics quirals en campanyes postintèntiques. Les bastides al·líliques que porten estereocentrisme quaternari basades en reaccions de substitució al·lílica catalitzades per Pd encara no es troben en cap cas. en aquesta tesi, hem desenvolupat una metodologia eficient i concisa per a la síntesi d’amines al·líliques aral a-a-desubstituïdes amb alts nivells de regio i enantioselectivitat. A continuació, vam desbloquejar l’origen de la regio- i l’enantioselectivitat en la inusual aminació al·lílica mitjançant càlculs de la teoria funcional de densitat (DFT) en combinació amb experiments de control mecanicista. Finalment, es van dissenyar lligams quirials nous i eficients i el seu ús en la síntesi en regio- i enantioselectiva de catalitzats de Pd de sulfones al·líliques ramificades. La utilitat del mètode es demostrarà més mitjançant la síntesi del sesquiterpè (-) - Agelasidine A.
Since the early seminal work by J. Tsuji and B. M. Trost, there has been rapid progress in the development of chiral ligands and scope of the electrophiles and nucleophiles in Pd-catalyzed allylic substitution reactions over the past few decades. In addition, Pd-catalyzed asymmetric allylic substitution reactions have been applied in total synthesis of a variety of complex chiral molecules, providing solid evidence of the efficiency of this methodology in controlling both regio- and enatioselectivities. Despite the numerous advances realized, forging chiral branched allylic derivatives from simple and readily available starting materials continues to be an important task in synthetic chemistry, due to the potential of the allylic moiety for further elaboration and asymmetric synthesis. The building allylic scaffolds bearing quaternary stereocenters based on Pd-catalyzed allylic substitution still remain rather underexplored. In this thesis, we have develop a concise and efficient methodology for synthesis of chiral a,a-disubtituted allylic amines with high levels of regio- and enantioselectivity. And then, we unlocked the origin of the regio- and enantioselectivity in the unusual allylic amination by density functional theory (DFT) calculations in combination with mechanistic control experiments.Finally, we designed a novel and highly efficient ligand to mediate regio- and enantioselective synthesis of various chiral allylic sulfones featuring quaternary stereocenters. The utility of the method will be further demonstrated by the synthesis of the sesquiterpene (-)-Agelasidine A.
Takeda, Momotaro. "Copper-Catalyzed Asymmetric Allylic Substitution with Organo- and Silylboronates." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188504.
Full textBaldwin, I. Craig. "New methodology involving allylic substitution and conjugate addition reactions." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/27583.
Full textDawson, Graham John. "Studies on the stereoselective palladium-catalysed allylic substitution reaction." Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/31866.
Full textTosatti, Paolo. "Metal-catalysed asymmetric allylic substitution reactions for array synthesis." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540583.
Full textKawatsura, Motoi. "Palladium-Catalyzed Allylic Substitution with a Monodentate Phosphine Ligand." 京都大学 (Kyoto University), 1998. http://hdl.handle.net/2433/157157.
Full textKyoto University (京都大学)
0048
新制・課程博士
博士(理学)
甲第7163号
理博第1937号
新制||理||1043(附属図書館)
UT51-98-G92
京都大学大学院理学研究科化学専攻
(主査)教授 林 民生, 教授 鈴木 仁美, 教授 大須賀 篤弘
学位規則第4条第1項該当
Ceban, Victor. "New methodologies in asymmetric allylic substitution and organocascade reactions." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/397983/.
Full textBooks on the topic "Allyic substitution"
Kazmaier, Uli, ed. Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-22749-3.
Full textKazmaier, Uli. Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2012.
Find full textPersson, Eva. Regiocontrol in copper(I)-catalyzed allylic substitution reactions with Grignard reagents: Mechanistic and synthetic aspects. Uppsala: Acta Universitatis Upsaliensis, 1995.
Find full textDawson, Graham John. Studies on the stereoselective palladium catalysed allylic substitution reaction. 1995.
Find full textBaldwin, Ian Craig. New methodology involving allylic substitution and conjugate addition reactions. 1996.
Find full textKazmaier, Uli. Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis. Springer, 2013.
Find full textBook chapters on the topic "Allyic substitution"
Hartwig, John F., and Mark J. Pouy. "Iridium-Catalyzed Allylic Substitution." In Iridium Catalysis, 169–208. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15334-1_7.
Full textJegelka, Markus, and Bernd Plietker. "Iron-Catalyzed Allylic Substitutions." In Asymmetric Synthesis II, 333–41. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527652235.ch42.
Full textLanglois, Jean-Baptiste, and Alexandre Alexakis. "Copper-catalyzed Enantioselective Allylic Substitution." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 235–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_12.
Full textMilhau, Ludovic, and Patrick J. Guiry. "Palladium-Catalyzed Enantioselective Allylic Substitution." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 95–153. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_9.
Full textLiu, Wen-Bo, Ji-Bao Xia, and Shu-Li You. "Iridium-Catalyzed Asymmetric Allylic Substitutions." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 155–207. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_10.
Full textPoli, Giovanni, Guillaume Prestat, Frédéric Liron, and Claire Kammerer-Pentier. "Selectivity in Palladium-Catalyzed Allylic Substitution." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 1–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_14.
Full textBegouin, Jeanne-Marie, Johannes E. M. N. Klein, Daniel Weickmann, and Bernd Plietker. "Allylic Substitutions Catalyzed by Miscellaneous Metals." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 269–320. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_15.
Full textTrost, Barry M., and Matthew L. Crawley. "Enantioselective Allylic Substitutions in Natural Product Synthesis." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 321–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_13.
Full textHornillos, Valentín, Jean-Baptiste Gualtierotti, and Ben L. Feringa. "Asymmetric Allylic Substitutions Using Organometallic Reagents." In Progress in Enantioselective Cu(I)-catalyzed Formation of Stereogenic Centers, 1–39. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/3418_2015_165.
Full textMoberg, Christina. "Molybdenum-Catalyzed and Tungsten-Catalyzed Enantioselective Allylic Substitutions." In Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis, 209–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/3418_2011_11.
Full textConference papers on the topic "Allyic substitution"
Brunel, Jean, Martin Smith, and Sebastien Reymond. "Enantioselective Palladium Catalyzed Allylic Substitution with New Multichiral Centers Monophosphine Ligands." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01841.
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