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Journal articles on the topic 'Alginate microfiber'

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Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

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1

Yokomizo, Akiyo, Yuya Morimoto, Keigo Nishimura, and Shoji Takeuchi. "Temporal Observation of Adipocyte Microfiber Using Anchoring Device." Micromachines 10, no. 6 (May 29, 2019): 358. http://dx.doi.org/10.3390/mi10060358.

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In this paper, we propose an anchoring device with pillars to immobilize an adipocyte microfiber that has a fiber-shaped adipocyte tissue covered by an alginate gel shell. Because the device enabled the immobilization of the microfiber in a culture dish even after its transportation and the exchange of the culture medium, we can easily track the specific positions of the microfiber for a long period. Owing to the characteristics of the anchoring device, we successfully performed temporal observations of the microfiber on the device for a month to investigate the function and morphology of three-dimensional cultured adipocytes. Furthermore, to demonstrate the applicability of the anchoring device to drug testing, we evaluated the lipolysis of the microfiber’s adipocytes by applying reagents with an anti-obesity effect. Therefore, we believe that the anchoring device with the microfiber will be a useful tool for temporal biochemical analyses.

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2

Keaswejjareansuk, Wisawat, Somrudee Keawmaloon, Nuttawat Sawangrat, Satit Puttipipatkhachorn, Teerapong Yata, Phornphimon Maitarad, Liyi Shi, Mattaka Khongkow, and Katawut Namdee. "Degradable alginate hydrogel microfiber for cell-encapsulation based on alginate lyase loaded nanoparticles." Materials Today Communications 28 (September 2021): 102701. http://dx.doi.org/10.1016/j.mtcomm.2021.102701.

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3

Nosova, N. G., O. V. Maikovych, О. Yu Bordeniuk, M. V. Yakoviv, and S. M. Varvarenko. "Reinforcement of alginate-gelatin hydrogel using functionalized polypropylene microfiber." Chemistry, Technology and Application of Substances 3, no. 1 (June 1, 2020): 232–38. http://dx.doi.org/10.23939/ctas2020.01.232.

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4

Dragoj, Miodrag, Jasmina Stojkovska, Tijana Stanković, Jelena Dinić, Ana Podolski-Renić, Bojana Obradović, and Milica Pešić. "Development and Validation of a Long-Term 3D Glioblastoma Cell Culture in Alginate Microfibers as a Novel Bio-Mimicking Model System for Preclinical Drug Testing." Brain Sciences 11, no. 8 (July 31, 2021): 1025. http://dx.doi.org/10.3390/brainsci11081025.

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Background: Various three-dimensional (3D) glioblastoma cell culture models have a limited duration of viability. Our aim was to develop a long-term 3D glioblastoma model, which is necessary for reliable drug response studies. Methods: Human U87 glioblastoma cells were cultured in alginate microfibers for 28 days. Cell growth, viability, morphology, and aggregation in 3D culture were monitored by fluorescent and confocal microscopy upon calcein-AM/propidium iodide (CAM/PI) staining every seven days. The glioblastoma 3D model was validated using temozolomide (TMZ) treatments 3 days in a row with a recovery period. Cell viability by MTT and resistance-related gene expression (MGMT and ABCB1) by qPCR were assessed after 28 days. The same TMZ treatment schedule was applied in 2D U87 cell culture for comparison purposes. Results: Within a long-term 3D model system in alginate fibers, U87 cells remained viable for up to 28 days. On day 7, cells formed visible aggregates oriented to the microfiber periphery. TMZ treatment reduced cell growth but increased drug resistance-related gene expression. The latter effect was more pronounced in 3D compared to 2D cell culture. Conclusion: Herein, we described a long-term glioblastoma 3D model system that could be particularly helpful for drug testing and treatment optimization.

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5

Kim, Byung, Intae Kim, WooSeok Choi, Sung Won Kim, JooSung Kim, and Geunbae Lim. "Fabrication of Cell-Encapsulated Alginate Microfiber Scaffold Using Microfluidic Channel." Journal of Manufacturing Science and Engineering 130, no. 2 (2008): 021016. http://dx.doi.org/10.1115/1.2898576.

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6

ZHANG, XULANG, and JIANHUA QIN. "MODIFIED ALGINATE/CHITOSAN HOLLOW MICROFIBER AS A BIOCOMPATIBLE FRAME FOR BLOOD VESSEL RECONSTRUCTION." Nano LIFE 02, no. 04 (December 2012): 1242005. http://dx.doi.org/10.1142/s1793984412420056.

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We presented a new approach to produce Chitosan–Glutaraldehyde–Chitosan–Alginate (CGCA) hollow fiber with the capability of cell capture and adhesion for vascular tissue engineering. The CGCA hollow fiber was generated by sacrificing the inner part of alginate/chitosan (A/C) solid fiber using sodium citrate, followed by glutaraldehyde (GA) cross-linking chitosan to form stable imine bonds on the fiber surface. Furthermore, human umbilical vein endothelial cells (HUVEC) were captured by the CGCA hollow fiber surface and adhesive as layer pattern with good viability and normal morphology. This strategy facilitated the lumen structure formation with good biocompatibility by biomaterials modification, providing a promising and facile technique for blood vessel regeneration in vitro and in vivo.

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7

Zhao, Junyi, Wei Xiong, Ning Yu, and Xing Yang. "Continuous Jetting of Alginate Microfiber in Atmosphere Based on a Microfluidic Chip." Micromachines 8, no. 1 (January 4, 2017): 8. http://dx.doi.org/10.3390/mi8010008.

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8

Liu, Hui, Yaqing Wang, Yue Yu, Wenwen Chen, Lei Jiang, and Jianhua Qin. "Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability." Journal of Biomedical Materials Research Part B: Applied Biomaterials 107, no. 8 (February 19, 2019): 2527–36. http://dx.doi.org/10.1002/jbm.b.34343.

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9

Leong, Meng Fatt, Hong Fang Lu, Tze Chiun Lim, Karthikeyan Narayanan, Shujun Gao, Luna Yue Wang, Rebecca P. K. Toh, et al. "Alginate Microfiber System for Expansion and Direct Differentiation of Human Embryonic Stem Cells." Tissue Engineering Part C: Methods 22, no. 9 (September 2016): 884–94. http://dx.doi.org/10.1089/ten.tec.2015.0561.

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10

Ran, Yang, Peng Xiao, Yongkang Zhang, Deming Hu, Zhiyuan Xu, Lili Liang, and Bai-Ou Guan. "A Miniature pH Probe Using Functional Microfiber Bragg Grating." Optics 1, no. 2 (August 11, 2020): 202–12. http://dx.doi.org/10.3390/opt1020016.

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Operando and precisely probing aqueous pH is fundamentally demanded, both in chemical and biological areas. Conventional pH probes, subjected to the larger size, are probably unfit for application in some extreme scenarios, such as a trace amount of samples. In this paper, we have further developed the pH sensor that leverages the microfiber Bragg grating with an ultra-compact size down to an order of magnitude of 10−14 m3. Using the electrostatic self-assembly layer-by-layer technique, the functional film consisting of sodium alginate, which harnesses a pH-dependent hygroscopicity, is immobilized on the fiber surface. Consequently, the alteration of aqueous pH could be quantitatively indicated by the wavelength shift of the grating resonance via the refractive index variation of the sensing film due to the water absorption or expulsion. The grating reflections involving fundamental mode and higher order mode exhibit the sensitivities of −72 pm/pH and −265 pm/pH, respectively. In addition, temperature compensation can be facilitated by the recording of the two reflections simultaneously. Furthermore, the modeling and simulation results predict the pivotal parameters of the configuration in sensitivity enhancement. The proposed proof-of-concept enriches the toolbox of pH sensor for catering to the need of detection in some extremely small spaces—for example, the living cells or the bio-tissues.

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11

Gao, Yingjun, and Xiangyu Jin. "Dual Crosslinked Methacrylated Alginate Hydrogel Micron Fibers and Tissue Constructs for Cell Biology." Marine Drugs 17, no. 10 (September 28, 2019): 557. http://dx.doi.org/10.3390/md17100557.

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As an important natural polysaccharide biomaterial from marine organisms, alginate and its derivatives have shown great potential in the fabrication of biomedical materials such as tissue engineering, cell biology, drug delivery, and pharmaceuticals due to their excellent biological activity and controllable physicochemical properties. Ionic crosslinking is the most common method used in the preparation of alginate-based biomaterials, but ionic crosslinked alginate hydrogels are prone to decompose in physiological solution, which hinders their applications in biomedical fields. In this study, dual crosslinked alginate hydrogel microfibers were prepared for the first time. The ionic crosslinked methacrylated alginate (Alg-MA) hydrogel microfibers fabricated by Microfluidic Fabrication (MFF) system were exposed to ultraviolet (UV) light and covalent crosslink between methacrylate groups avoided the fracture of dual crosslinked macromolecular chains in organizational environment. The chemical structures, swelling ratio, mechanical performance, and stability were investigated. Cell-encapsulated dual crosslinked Alg-MA hydrogel microfibers were fabricated to explore the application in tissue engineering for the first time. The hydrogel microfibers provided an excellent 3D distribution and growth conditions for cells. Cell-encapsulated Alg-MA microfibers scaffolds with functional 3D tissue structures were developed which possessed great potential in the production of next-generation scaffolds for tissue engineering and regenerative medicine.

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12

Meng, Zhi-Jun, Wei Wang, Rui Xie, Xiao-Jie Ju, Zhuang Liu, and Liang-Yin Chu. "Microfluidic generation of hollow Ca-alginate microfibers." Lab on a Chip 16, no. 14 (2016): 2673–81. http://dx.doi.org/10.1039/c6lc00640j.

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Controllable hollow Ca-alginate microfibers are continuously fabricated from microfluidic four-aqueous-phase flow templates, which contain a buffer flow between Ca²⁺ and alginate flows for prevention of rapid Ca²⁺/alginate crosslinking.

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13

Yu, Yunru, Guopu Chen, Jiahui Guo, Yuxiao Liu, Jianan Ren, Tiantian Kong, and Yuanjin Zhao. "Vitamin metal–organic framework-laden microfibers from microfluidics for wound healing." Materials Horizons 5, no. 6 (2018): 1137–42. http://dx.doi.org/10.1039/c8mh00647d.

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14

Palma Santana, Bianca, Fernanda Nedel, Evandro Piva, Rodrigo Varella de Carvalho, Flávio Fernando Demarco, and Neftali Lenin Villarreal Carreño. "Preparation, Modification, and Characterization of Alginate Hydrogel with Nano-/Microfibers: A New Perspective for Tissue Engineering." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/307602.

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We aimed to develop an alginate hydrogel (AH) modified with nano-/microfibers of titanium dioxide (nfTD) and hydroxyapatite (nfHY) and evaluated its biological and chemical properties. Nano-/microfibers of nfTD and nfHY were combined with AH, and its chemical properties were evaluated by FTIR spectroscopy, X-ray diffraction, energy dispersive X-Ray analysis, and the cytocompatibility by the WST-1 assay. The results demonstrate that the association of nfTD and nfHY nano-/microfibers to AH did not modified the chemical characteristics of the scaffold and that the association was not cytotoxic. In the first 3 h of culture with NIH/3T3 cells nfHY AH scaffolds showed a slight increase in cell viability when compared to AH alone or associated with nfTD. However, an increase in cell viability was observed in 24 h when nfTD was associated with AH scaffold. In conclusion our study demonstrates that the combination of nfHY and nfTD nano-/microfibers in AH scaffold maintains the chemical characteristics of alginate and that this association is cytocompatible. Additionally the combination of nfHY with AH favored cell viability in a short term, and the addition of nfTD increased cell viability in a long term.

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15

Zhao, Mengqian, Haitao Liu, Xu Zhang, Hui Wang, Tingting Tao, and Jianhua Qin. "A flexible microfluidic strategy to generate grooved microfibers for guiding cell alignment." Biomaterials Science 9, no. 14 (2021): 4880–90. http://dx.doi.org/10.1039/d1bm00549a.

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16

Wang, Gen, Luanluan Jia, Fengxuan Han, Jiayuan Wang, Li Yu, Yingkang Yu, Gareth Turnbull, Mingyu Guo, Wenmiao Shu, and Bin Li. "Microfluidics-Based Fabrication of Cell-Laden Hydrogel Microfibers for Potential Applications in Tissue Engineering." Molecules 24, no. 8 (April 25, 2019): 1633. http://dx.doi.org/10.3390/molecules24081633.

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Fibrous hydrogel scaffolds have recently attracted increasing attention for tissue engineering applications. While a number of approaches have been proposed for fabricating microfibers, it remains difficult for current methods to produce materials that meet the essential requirements of being simple, flexible and bio-friendly. It is especially challenging to prepare cell-laden microfibers which have different structures to meet the needs of various applications using a simple device. In this study, we developed a facile two-flow microfluidic system, through which cell-laden hydrogel microfibers with various structures could be easily prepared in one step. Aiming to meet different tissue engineering needs, several types of microfibers with different structures, including single-layer, double-layer and hollow microfibers, have been prepared using an alginate-methacrylated gelatin composite hydrogel by merely changing the inner and outer fluids. Cell-laden single-layer microfibers were obtained by subsequently seeding mouse embryonic osteoblast precursor cells (MC3T3-E1) cells on the surface of the as-prepared microfibers. Cell-laden double-layer and hollow microfibers were prepared by directly encapsulating MC3T3-E1 cells or human umbilical vein endothelial cells (HUVECs) in the cores of microfibers upon their fabrication. Prominent proliferation of cells happened in all cell-laden single-layer, double-layer and hollow microfibers, implying potential applications for them in tissue engineering.

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17

Chaurasia, Ankur Shubhlal, and Shahriar Sajjadi. "Transformable bubble-filled alginate microfibers via vertical microfluidics." Lab on a Chip 19, no. 5 (2019): 851–63. http://dx.doi.org/10.1039/c8lc01081a.

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18

Radonjic, Mia, Jelena Petrovic, Milena Milivojevic, Milena Stevanovic, Jasmina Stojkovska, and Bojana Obradovic. "Chemical engineering methods in analyses of 3D cancer cell cultures: Hydrodinamic and mass transport considerations." Chemical Industry and Chemical Engineering Quarterly, no. 00 (2021): 33. http://dx.doi.org/10.2298/ciceq210607033r.

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A multidisciplinary approach based on experiments and mathematical modeling was used in biomimetic system development for three-dimensional (3D) cultures of cancer cells. Specifically, two cancer cell lines, human embryonic teratocarcinoma NT2/D1 and rat glioma C6, were immobilized in alginate microbeads and microfibers, respectively, and cultured under static and flow conditions in perfusion bioreactors, while chemical engineering methods were applied to explain the obtained results. The superficial medium velocity of 80 mm s-1 induced lower viability of NT2/D1 cells in superficial microbead zones implying adverse effects of fluid shear stresses estimated as ~67 mPa. On the contrary, similar velocity (100 mm s-1) enhanced proliferation of C6 glioma cells within microfibers as compared to static controls. An additional study of silver release from nanocomposite Ag/honey/alginate microfibers under perfusion indicated that medium partially flows through the hydrogel (interstitial velocity of ~10 nm s-1). Thus, a diffusion-advection-reaction model was applied to describe the mass transport to immobilized cells within microfibers. Substances with diffusion coefficients of ?10-9-10-11 m2 s-1 are sufficiently supplied by diffusion only, while those with significantly lower diffusivities (?10-19 m2 s-1) require additional convective transport. The present study demonstrates the selection and contribution of chemical engineering methods in tumor model system development.

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19

Ji, Xiaobo, Song Guo, Changfeng Zeng, Chongqing Wang, and Lixiong Zhang. "Continuous generation of alginate microfibers with spindle-knots by using a simple microfluidic device." RSC Advances 5, no. 4 (2015): 2517–22. http://dx.doi.org/10.1039/c4ra10389k.

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Calcium alginate microfibers with spindle-knots are fabricated by combining microfluidic technique with wet-spinning method. The structures of the knots can be conveniently regulated by changing the two-phase flow rate ratio and the micropipette diameter.

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20

Guo, Jiahui, Yunru Yu, Dagan Zhang, Han Zhang, and Yuanjin Zhao. "Morphological Hydrogel Microfibers with MXene Encapsulation for Electronic Skin." Research 2021 (March 3, 2021): 1–10. http://dx.doi.org/10.34133/2021/7065907.

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Electronic skins with distinctive features have attracted remarkable attention from researchers because of their promising applications in flexible electronics. Here, we present novel morphologically conductive hydrogel microfibers with MXene encapsulation by using a multi-injection coflow glass capillary microfluidic chip. The coaxial flows in microchannels together with fast gelation between alginate and calcium ions ensure the formation of hollow straight as well as helical microfibers and guarantee the in situ encapsulation of MXene. The resultant hollow straight and helical MXene hydrogel microfibers were with highly controllable morphologies and package features. Benefiting from the easy manipulation of the microfluidics, the structure compositions and the sizes of MXene hydrogel microfibers could be easily tailored by varying different flow rates. It was demonstrated that these morphologically conductive MXene hydrogel microfibers were with outstanding capabilities of sensitive responses to motion and photothermal stimulations, according to their corresponding resistance changes. Thus, we believe that our morphologically conductive MXene hydrogel microfibers with these excellent features will find important applications in smart flexible electronics especially electronic skins.

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21

McNamara, Marilyn C., Ryan J. Pretzer, Reza Montazami, and Nicole N. Hashemi. "Shear at Fluid-Fluid Interfaces Affects the Surface Topologies of Alginate Microfibers." Clean Technologies 1, no. 1 (September 2, 2019): 265–72. http://dx.doi.org/10.3390/cleantechnol1010018.

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Hydrogel microfibers have great potential for applications such as tissue engineering or three-dimensional cell culturing. Their favorable attributes can lead to tissue models that can help to reduce or eliminate animal testing, thereby providing an eco-friendly alternative to this unsustainable process. In addition to their highly tunable mechanical properties, this study shows that varying the viscosity and flow rates of the prepolymer core solution and gellator sheath solution within a microfluidic device can affect the surface topology of the resulting microfibers. Higher viscosity core solutions are more resistant to deformation from shear force within the microfluidic device, thereby yielding smoother fibers. Similarly, maintaining a smaller velocity gradient between the fluids within the microfluidic device minimizes shear force and smooths fiber surfaces. This simple modification provides insight into manufacturing microfibers with highly tunable properties.

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22

Sharma, Ameya, Vivek Puri, Pradeep Kumar, Inderbir Singh, and Kampanart Huanbutta. "Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers." Polymers 13, no. 9 (May 8, 2021): 1514. http://dx.doi.org/10.3390/polym13091514.

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Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications.

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23

Chaurasia, A. S., F. Jahanzad, and S. Sajjadi. "Flexible microfluidic fabrication of oil-encapsulated alginate microfibers." Chemical Engineering Journal 308 (January 2017): 1090–97. http://dx.doi.org/10.1016/j.cej.2016.09.054.

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24

Huang, Qiwei, Yingyi Li, Longfei Fan, John H. Xin, Hui Yu, and Dongdong Ye. "Polymorphic calcium alginate microfibers assembled using a programmable microfluidic field for cell regulation." Lab on a Chip 20, no. 17 (2020): 3158–66. http://dx.doi.org/10.1039/d0lc00517g.

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25

Chaurasia, A. S., F. Jahanzad, and S. Sajjadi. "Preparation and characterization of tunable oil-encapsulated alginate microfibers." Materials & Design 128 (August 2017): 64–70. http://dx.doi.org/10.1016/j.matdes.2017.04.069.

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26

Asthana, Amit, Kwang Ho Lee, Su-Jung Shin, Jayakumar Perumal, Lauren Butler, Sang-Hoon Lee, and Dong-Pyo Kim. "Bromo-oxidation reaction in enzyme-entrapped alginate hollow microfibers." Biomicrofluidics 5, no. 2 (June 2011): 024117. http://dx.doi.org/10.1063/1.3605512.

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27

Zhao, Junyi, Junwen Zhu, Ning Yu, Wei Xiong, and Xing Yang. "Fabrication of oriented carbon nanotube–alginate microfibers using a microfluidic device." Functional Materials Letters 12, no. 06 (December 2019): 1940002. http://dx.doi.org/10.1142/s1793604719400022.

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With the progress of microelectronic devices, more attention has been paid to carbon nanotube (CNTs) because of their excellent mechanical and electrical properties. A microfluidic-based method for fabricating oriented CNT strain-sensitive fibers is proposed in this work. By manipulating CNTs, NaAlg and CaCl2 solutions in a three-coaxial laminar flow glass capillary device, CNTs can be arranged in an oriented manner and solidified into microfibers with a hydrogel shell through a chemical polymerization reaction. The diameter of the fiber could be controlled by the microfluidic device. Scanning electron microscopy and Raman spectroscopy show that the CNTs are perfectly aligned along the fiber axis under the influence of the viscous drag force of the fluid, and the electrical and mechanical properties of the CNT fibers are obviously strengthened. Experiments suggest that the devices based on the oriented CNT–alginate microfibers are able to achieve simple motion monitoring function. The proposed microfluidic method is simple, cost effective and can be applied to produce functional nanomaterial fibers for application in flexible devices.

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28

Zhang, Xiaolin, Lin Weng, Qingsheng Liu, Dawei Li, and Bingyao Deng. "Facile fabrication and characterization on alginate microfibres with grooved structure via microfluidic spinning." Royal Society Open Science 6, no. 5 (May 2019): 181928. http://dx.doi.org/10.1098/rsos.181928.

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Alginate microfibres were fabricated by a simple microfluidic spinning device consisting of a coaxial flow. The inner profile and spinnability of polymer were analysed by rheology study, including the analysis of viscosity, storage modulus and loss modulus. The effect of spinning parameters on the morphological structure of fibres was studied by SEM, while the crystal structure and chemical group were characterized by FTIR and XRD, respectively. Furthermore, the width and depth of grooves on the fibres was investigated by AFM image analysis and the formation mechanism of grooves was finally analysed. It was illustrated that the fibre diameter increased with an increase in the core flow rate, whereas on the contrary of sheath flow rate. Fibre diameter exhibited an increasing tendency as the concentration of alginate solution increased, and the minimum spinning concentration of alginate solution was 1% with the finest diameter being around 25 µm. Importantly, the grooved structure was obtained by adjusting the concentration of solutions and flow rates, the depth of groove increased from 278.37 ± 2.23 µm to 727.52 ± 3.52 µm as the concentration varied from 1 to 2%. Alginate fibres, with topological structure, are candidates for wound dressing or the engineering tissue scaffolds.

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Park, Jeong-Hui, Ueon-Sang Shin, and Hae-Won Kim. "Alginate-Microfibers Produced by Self-Assembly in Cell Culture Medium." Bulletin of the Korean Chemical Society 32, no. 2 (February 20, 2011): 431–33. http://dx.doi.org/10.5012/bkcs.2011.32.2.431.

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Zhao, Yun, Mingjie Li, Jun Qiu, Qingshan Kong, Yue Zhang, and Chaoxu Li. "Alginate-assisted synthesis of hollow microfibers assembled by SnO2 nanoparticles." Materials & Design 101 (July 2016): 317–22. http://dx.doi.org/10.1016/j.matdes.2016.03.157.

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31

Su, Jing, Yizhe Zheng, and Hongkai Wu. "Generation of alginate microfibers with a roller-assisted microfluidic system." Lab Chip 9, no. 7 (2009): 996–1001. http://dx.doi.org/10.1039/b813518e.

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32

Zhou, Meiling, Jinghua Gong, and Jinghong Ma. "Continuous fabrication of near-infrared light responsive bilayer hydrogel fibers based on microfluidic spinning." e-Polymers 19, no. 1 (May 29, 2019): 215–24. http://dx.doi.org/10.1515/epoly-2019-0022.

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AbstractHydrogel microfibers with inhomogenous structure can achieve some complex motions such as bending, folding and twisting. So it can be applied to soft actuators, soft robots and micropumps. In this paper, continuous bilayer hydrogel fibers in which one layer is calcium alginate hydrogel and the other is linear poly(N-isopropylacrylamide) (PNIPAM)/calcium alginate/graphene oxide (GO) semi-interpenetrating hydrogel were prepared based on microfluidic spinning method. The results show that the bilayer hydrogel fibers have particular porous internal structures of semi-IPN hydrogels and the pore size becomes smaller with the increase of GO content. Besides, the bilayer hydrogel fibers can bend response to the temperature and near-infrared (NIR) light. The diameter of the hydrogel fibers can be tuned by changing the flow rate of spinning fluid and the take-up velocity of winding device.

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Liu, Rui, Bin Kong, Yun Chen, Xueping Liu, and Shengli Mi. "Formation of helical alginate microfibers using different G/M ratios of sodium alginate based on microfluidics." Sensors and Actuators B: Chemical 304 (February 2020): 127069. http://dx.doi.org/10.1016/j.snb.2019.127069.

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Nishimura, Keigo, Yuya Morimoto, Nobuhito Mori, and Shoji Takeuchi. "Formation of Branched and Chained Alginate Microfibers Using Theta-Glass Capillaries." Micromachines 9, no. 6 (June 17, 2018): 303. http://dx.doi.org/10.3390/mi9060303.

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35

Sun, Tao, Xingfu Li, Qing Shi, Huaping Wang, Qiang Huang, and Toshio Fukuda. "Microfluidic Spun Alginate Hydrogel Microfibers and Their Application in Tissue Engineering." Gels 4, no. 2 (April 23, 2018): 38. http://dx.doi.org/10.3390/gels4020038.

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36

Djomehri, Sabra, Hanaa Zeid, Alireza Yavari, Maryam Mobed-Miremadi, Kenneth Youssefi, and Sindy Liao-Chan. "Simulation and verification of macroscopic isotropy of hollow alginate-based microfibers." Artificial Cells, Nanomedicine, and Biotechnology 43, no. 6 (April 2014): 390–97. http://dx.doi.org/10.3109/21691401.2014.897629.

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37

Hu, Xili, Mingwei Tian, Bing Sun, Lijun Qu, Shifeng Zhu, and Xiansheng Zhang. "Hydrodynamic alignment and microfluidic spinning of strength-reinforced calcium alginate microfibers." Materials Letters 230 (November 2018): 148–51. http://dx.doi.org/10.1016/j.matlet.2018.07.092.

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38

Szymanski, John M., and Adam W. Feinberg. "Fabrication of freestanding alginate microfibers and microstructures for tissue engineering applications." Biofabrication 6, no. 2 (April 3, 2014): 024104. http://dx.doi.org/10.1088/1758-5082/6/2/024104.

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Sun, Tao, Huaping Wang, Qing Shi, Masaru Takeuchi, Masahiro Nakajima, Qiang Huang, and Toshio Fukuda. "Micromanipulation for Coiling Microfluidic Spun Alginate Microfibers by Magnetically Guided System." IEEE Robotics and Automation Letters 1, no. 2 (July 2016): 808–13. http://dx.doi.org/10.1109/lra.2016.2524991.

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Homem, Natália C., Tânia D. Tavares, Catarina S. Miranda, Joana C. Antunes, M. Teresa P. Amorim, and Helena P. Felgueiras. "Functionalization of Crosslinked Sodium Alginate/Gelatin Wet-Spun Porous Fibers with Nisin Z for the Inhibition of Staphylococcus aureus-Induced Infections." International Journal of Molecular Sciences 22, no. 4 (February 16, 2021): 1930. http://dx.doi.org/10.3390/ijms22041930.

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Nisin Z, an amphipathic peptide, with a significant antibacterial activity against Gram-positive bacteria and low toxicity in humans, has been studied for food preservation applications. Thus far, very little research has been done to explore its potential in biomedicine. Here, we report the modification of sodium alginate (SA) and gelatin (GN) blended microfibers, produced via the wet-spinning technique, with Nisin Z, with the purpose of eradicating Staphylococcus aureus-induced infections. Wet-spun SAGN microfibers were successfully produced at a 70/30% v/v of SA (2 wt%)/GN (1 wt%) polymer ratio by extrusion within a calcium chloride (CaCl2) coagulation bath. Modifications to the biodegradable fibers’ chemical stability and structure were then introduced via crosslinking with CaCl2 and glutaraldehyde (SAGNCL). Regardless of the chemical modification employed, all microfibers were labelled as homogeneous both in size (≈246.79 µm) and shape (cylindrical and defect-free). SA-free microfibers, with an increased surface area for peptide immobilization, originated from the action of phosphate buffer saline solution on SAGN fibers, were also produced (GNCL). Their durability in physiological conditions (simulated body fluid) was, however, compromised very early in the experiment (day 1 and 3, with and without Nisin Z, respectively). Only the crosslinked SAGNCL fibers remained intact for the 28 day-testing period. Their thermal resilience in comparison with the unmodified and SA-free fibers was also demonstrated. Nisin Z was functionalized onto the unmodified and chemically altered fibers at an average concentration of 178 µg/mL. Nisin Z did not impact on the fiber’s morphology nor on their chemical/thermal stability. However, the peptide improved the SA fibers (control) structural integrity, guaranteeing its stability for longer, in physiological conditions. Its main effect was detected on the time-kill kinetics of the bacteria S. aureus. SAGNCL and GNCL loaded with Nisin Z were capable of progressively eliminating the bacteria, reaching an inhibition superior to 99% after 24 h of culture. The peptide-modified SA and SAGN were not as effective, losing their antimicrobial action after 6 h of incubation. Bacteria elimination was consistent with the release kinetics of Nisin Z from the fibers. In general, data revealed the increased potential and durable effect of Nisin Z (significantly superior to its free, unloaded form) against S. aureus-induced infections, while loaded onto prospective biomedical wet-spun scaffolds.

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Angelozzi, Marco, Martina Miotto, Letizia Penolazzi, Stefania Mazzitelli, Timothy Keane, Stephen F. Badylak, Roberta Piva, and Claudio Nastruzzi. "Composite ECM–alginate microfibers produced by microfluidics as scaffolds with biomineralization potential." Materials Science and Engineering: C 56 (November 2015): 141–53. http://dx.doi.org/10.1016/j.msec.2015.06.004.

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Meng, Lei, Changyou Shao, and Jun Yang. "Ionically Cross-Linked Silk Microfibers/Alginate Tough Composite Hydrogels with Hierarchical Structures." ACS Sustainable Chemistry & Engineering 6, no. 12 (October 23, 2018): 16788–96. http://dx.doi.org/10.1021/acssuschemeng.8b04055.

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Bonhomme, Oriane, Jacques Leng, and Annie Colin. "Microfluidic wet-spinning of alginate microfibers: a theoretical analysis of fiber formation." Soft Matter 8, no. 41 (2012): 10641. http://dx.doi.org/10.1039/c2sm25552a.

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Hu, Chengzhi, Masahiro Nakajima, Tao Yue, Masaru Takeuchi, Minoru Seki, Qiang Huang, and Toshio Fukuda. "On-chip fabrication of magnetic alginate hydrogel microfibers by multilayered pneumatic microvalves." Microfluidics and Nanofluidics 17, no. 3 (December 29, 2013): 457–68. http://dx.doi.org/10.1007/s10404-013-1325-3.

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Shin, Jung Hwal, Jin Hwa Jung, Hyoryung Nam, Sung Won Kim, Dong-Woo Cho, and Geunbae Lim. "Implantation of encapsulated human septal chondrocytes into immunocompetent mice using alginate microfibers." BioChip Journal 9, no. 1 (March 2015): 67–75. http://dx.doi.org/10.1007/s13206-014-9109-8.

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Campiglio, Chiara, Francesca Ceriani, and Lorenza Draghi. "3D Encapsulation Made Easy: A Coaxial-Flow Circuit for the Fabrication of Hydrogel Microfibers Patches." Bioengineering 6, no. 2 (April 6, 2019): 30. http://dx.doi.org/10.3390/bioengineering6020030.

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To fully exploit the potential of hydrogel micro-fibers in the design of regenerative medicinal materials, we designed a simple, easy to replicate system for cell embedding in degradable fibrous scaffolds, and validated its effectiveness using alginate-based materials. For scaffold fabrication, cells are suspended in a hydrogel-precursor and injected in a closed-loop circuit, where a pump circulates the ionic cross-linking solution. The flow of the cross-linking solution stretches and solidifies a continuous micro-scaled, cell-loaded hydrogel fiber that whips, bends, and spontaneously assembles in a self-standing, spaghetti-like patch. After investigation and tuning of process- and solution-related parameters, homogeneous microfibers with controlled diameters and consistent scaffolds were obtained from different alginate concentrations and blends with biologically favorable macromolecules (i.e., gelatin or hyaluronic acid). Despite its simplicity, this coaxial-flow encapsulation system allows for the rapid and effortless fabrication of thick, well-defined scaffolds, with viable cells being homogeneously distributed within the fibers. The reduced fiber diameter and the inherent macro-porous structure that is created from the random winding of fibers can sustain mass transport, and support encapsulated cell survival. As different materials and formulations can be processed to easily create homogeneously cell-populated structures, this system appears as a valuable platform, not only for regenerative medicine, but also, more in general, for 3D cell culturing in vitro.

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Sun, Tao, Qing Shi, Qiang Huang, Huaping Wang, Xiaolu Xiong, Chengzhi Hu, and Toshio Fukuda. "Magnetic alginate microfibers as scaffolding elements for the fabrication of microvascular-like structures." Acta Biomaterialia 66 (January 2018): 272–81. http://dx.doi.org/10.1016/j.actbio.2017.11.038.

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Stojkovska, Jasmina, Jovana Zvicer, Milena Milivojevic, Isidora Petrovic, Milena Stevanovic, and Bojana Obradovic. "Validation of a novel perfusion bioreactor system in cancer research." Chemical Industry 74, no. 3 (2020): 187–96. http://dx.doi.org/10.2298/hemind200329015s.

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Development of drugs is a complex, time- and cost-consuming process due to the lack of standardized and reliable characterization techniques and models. Traditionally, drug screening is based on in vitro analysis using two-dimensional (2D) cell cultures followed by in vivo animal testing. Unfortunately, application of the obtained results to humans in about 90 % of cases fails. Therefore, it is important to develop and improve cell-based systems that can mimic the in vivo-like conditions to provide more reliable results. In this paper, we present development and validation of a novel, user-friendly perfusion bioreactor system for single use aimed for cancer research, drug screening, anti-cancer drug response studies, biomaterial characterization, and tissue engineering. Simple design of the perfusion bioreactor provides direct medium flow at physiological velocities (100?250 ?m s-1) through samples of different sizes and shapes. Biocompatibility of the bioreactor was confirmed in short term cultivation studies of cervical carcinoma SiHa cells immobilized in alginate microfibers under continuous medium flow. The results have shown preserved cell viability indicating that the perfusion bioreactor in conjunction with alginate hydrogels as cell carriers could be potentially used as a tool for controlled anti-cancer drug screening in a 3D environment.

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Lee, Bo Ram, Kwang Ho Lee, Edward Kang, Dong-Sik Kim, and Sang-Hoon Lee. "Microfluidic wet spinning of chitosan-alginate microfibers and encapsulation of HepG2 cells in fibers." Biomicrofluidics 5, no. 2 (June 2011): 022208. http://dx.doi.org/10.1063/1.3576903.

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Saeki, Kotone, Hisataka Hiramatsu, Ayaka Hori, Yu Hirai, Masumi Yamada, Rie Utoh, and Minoru Seki. "Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation." ACS Omega 5, no. 34 (August 20, 2020): 21641–50. http://dx.doi.org/10.1021/acsomega.0c02385.

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