Relevant bibliographies by topics / Alginate-encapsulated structures

Academic literature on the topic 'Alginate-encapsulated structures'

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Published: 30 May 2022
Last updated: 31 May 2022

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Journal articles on the topic "Alginate-encapsulated structures"

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Gao, Yingjun, and Xiangyu Jin. "Dual Crosslinked Methacrylated Alginate Hydrogel Micron Fibers and Tissue Constructs for Cell Biology." Marine Drugs 17, no. 10 (September 28, 2019): 557. http://dx.doi.org/10.3390/md17100557.

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As an important natural polysaccharide biomaterial from marine organisms, alginate and its derivatives have shown great potential in the fabrication of biomedical materials such as tissue engineering, cell biology, drug delivery, and pharmaceuticals due to their excellent biological activity and controllable physicochemical properties. Ionic crosslinking is the most common method used in the preparation of alginate-based biomaterials, but ionic crosslinked alginate hydrogels are prone to decompose in physiological solution, which hinders their applications in biomedical fields. In this study, dual crosslinked alginate hydrogel microfibers were prepared for the first time. The ionic crosslinked methacrylated alginate (Alg-MA) hydrogel microfibers fabricated by Microfluidic Fabrication (MFF) system were exposed to ultraviolet (UV) light and covalent crosslink between methacrylate groups avoided the fracture of dual crosslinked macromolecular chains in organizational environment. The chemical structures, swelling ratio, mechanical performance, and stability were investigated. Cell-encapsulated dual crosslinked Alg-MA hydrogel microfibers were fabricated to explore the application in tissue engineering for the first time. The hydrogel microfibers provided an excellent 3D distribution and growth conditions for cells. Cell-encapsulated Alg-MA microfibers scaffolds with functional 3D tissue structures were developed which possessed great potential in the production of next-generation scaffolds for tissue engineering and regenerative medicine.
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Nair, Kalyani, Karen Yan, and Wei Sun. "A multilevel numerical model quantifying cell deformation in encapsulated alginate structures." Journal of Mechanics of Materials and Structures 2, no. 6 (August 1, 2007): 1121–39. http://dx.doi.org/10.2140/jomms.2007.2.1121.

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Namgung, Bumseok, Kalpana Ravi, Pooja Prathyushaa Vikraman, Shiladitya Sengupta, and Hae Lin Jang. "Engineered cell-laden alginate microparticles for 3D culture." Biochemical Society Transactions 49, no. 2 (April 16, 2021): 761–73. http://dx.doi.org/10.1042/bst20200673.

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Advanced microfabrication technologies and biocompatible hydrogel materials facilitate the modeling of 3D tissue microenvironment. Encapsulation of cells in hydrogel microparticles offers an excellent high-throughput platform for investigating multicellular interaction with their surrounding microenvironment. Compartmentalized microparticles support formation of various unique cellular structures. Alginate has emerged as one of the most dominant hydrogel materials for cell encapsulation owing to its cytocompatibility, ease of gelation, and biocompatibility. Alginate hydrogel provides a permeable physical boundary to the encapsulated cells and develops an easily manageable 3D cellular structure. The interior structure of alginate hydrogel can further regulate the spatiotemporal distribution of the embedded cells. This review provides a specific overview of the representative engineering approaches to generate various structures of cell-laden alginate microparticles in a uniform and reproducible manner. Capillary nozzle systems, microfluidic droplet systems, and non-chip based high-throughput microfluidic systems are highlighted for developing well-regulated cellular structure in alginate microparticles to realize potential drug screening platform and cell-based therapy. We conclude with the discussion of current limitations and future directions for realizing the translation of this technology to the clinic.
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Sun, Xubing, Jiayong Zhang, Guowen Ding, and Yaohui You. "Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal." Water Science and Technology 81, no. 5 (March 1, 2020): 936–48. http://dx.doi.org/10.2166/wst.2020.178.

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Abstract A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution. Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated. The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal. The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step. The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively. The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption. The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
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Conte, Amalia, Lucia Lecce, Mariapia Iannetti, and Matteo Alessandro Del Nobile. "Study on the Influence of Bio-Based Packaging System on Sodium Benzoate Release Kinetics." Foods 9, no. 8 (July 27, 2020): 1010. http://dx.doi.org/10.3390/foods9081010.

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The influence of film structure on the release kinetics of sodium benzoate (SB) from polymeric films is addressed in this study. In particular, four film structures were investigated, two monolayer and two multilayer systems. In particular, in one case, the active substance was uniformly distributed into a chitosan-based matrix, and in the other one, it was previously incorporated into alginate beads before dispersion in the chitosan film, thus realizing two types of monolayer films; on the other hand, the same chitosan film with SB encapsulated in alginate beads was used as the inner layer of a multilayer system constituted by two side films of alginate. The two alginate-based layers were made with two different thicknesses, thus producing a total of two multilayer systems. The release of SB from the above-mentioned films in water was studied by means of a UV/VIS spectrophotometer at 227 nm. A first-order kinetics-type equation was used to quantitatively describe the release data. Results suggest that the film structure strongly affected the release kinetics. In fact, monolayer films showed single-stage release kinetics, whereas the two investigated multilayer systems showed two-stage release kinetics. Further, the presence of alginate beads strongly affected the SB release, thus suggesting the potential of encapsulation to control the release mechanism of active compounds.
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Hamilton, Charles, Gursel Alici, Geoff Spinks, and Marc in het Panhuis. "The Suitability of 3-D Printed Eutectic Gallium-Indium Alloy as a Heating Element for Thermally Active Hydrogels." MRS Advances 2, no. 6 (December 15, 2016): 335–40. http://dx.doi.org/10.1557/adv.2016.618.

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ABSTRACTWe report the use of a novel extrusion tip that allows for the omnidirectional printing of eutectic gallium-indium (eGaIn) alloy onto the surface of hydrogel materials into complex 2-dimensional patterns. The use of these printed soft “wires” as an electrothermal heating element for soft robotics purposes was explored. Heating of the eGaIn structures encapsulated in an alginate/acrylamide ionic-covalent entanglement hydrogel was measured by a thermal imaging camera. It was determined that eGaIn is a suitable material for use in future soft robotics applications as an electrothermal heating element to actuate thermally responsive N-isoproylacrylamide hydrogels.
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Cigu, Toni Andor, Mihaela Nicoleta Holban, Anca Niculina Cadinoiu, Valeriu Sunel, Catalina Lionte, Marcel Popa, Jacques Desbrieres, and Corina Cheptea. "Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections." Materiale Plastice 54, no. 1 (March 30, 2017): 160–67. http://dx.doi.org/10.37358/mp.17.1.4808.

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The aim of this research was the synthesis of novel 2,3-disubstituted 1,3 thiazolidines, derived from 5-nitroindazole with antimicrobial activity and their encapsulation into polymer nanocapsules. Starting from previously synthesised hydrazones, there have been obtained novel thiazolidines by reaction with thioglycolic acid. The envisaged chemical structures were confirmed by spectral and elemental analysis. Two of the obtained thiazolidines were encapsulated into cationic Eudragit E100 nanocapsules, obtained by nanoprecipitation. In order to enhance drug release characteristics and particle stability, Eudragit E100 nanocapsules were covered with anionic polysaccharide (sodium alginate), thus forming a complex polyelectrolyte based membrane. The obtained nanocapsules presented a slower and more controlled drug release. The synthesized active principles, in free state and encapsulated into polymer nanocapsules, were tested for their acute toxicity and their influence on the development of model bacterial strains (Staphylococcus mutans, Actinobacillus actinomycetemcomitans, Bacillus subtilis, Bacillus cereus, Salmonella enteritidis, Escherichia coli and Staphylococcus aureus).
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Gryshkov, Oleksandr, Vitalii Mutsenko, Dmytro Tarusin, Diaa Khayyat, Ortwin Naujok, Ekaterina Riabchenko, Yuliia Nemirovska, Arseny Danilov, Alexander Y. Petrenko, and Birgit Glasmacher. "Coaxial Alginate Hydrogels: From Self-Assembled 3D Cellular Constructs to Long-Term Storage." International Journal of Molecular Sciences 22, no. 6 (March 18, 2021): 3096. http://dx.doi.org/10.3390/ijms22063096.

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Alginate as a versatile naturally occurring biomaterial has found widespread use in the biomedical field due to its unique features such as biocompatibility and biodegradability. The ability of its semipermeable hydrogels to provide a favourable microenvironment for clinically relevant cells made alginate encapsulation a leading technology for immunoisolation, 3D culture, cryopreservation as well as cell and drug delivery. The aim of this work is the evaluation of structural properties and swelling behaviour of the core-shell capsules for the encapsulation of multipotent stromal cells (MSCs), their 3D culture and cryopreservation using slow freezing. The cells were encapsulated in core-shell capsules using coaxial electrospraying, cultured for 35 days and cryopreserved. Cell viability, metabolic activity and cell–cell interactions were analysed. Cryopreservation of MSCs-laden core-shell capsules was performed according to parameters pre-selected on cell-free capsules. The results suggest that core-shell capsules produced from the low viscosity high-G alginate are superior to high-M ones in terms of stability during in vitro culture, as well as to solid beads in terms of promoting formation of viable self-assembled cellular structures and maintenance of MSCs functionality on a long-term basis. The application of 0.3 M sucrose demonstrated a beneficial effect on the integrity of capsules and viability of formed 3D cell assemblies, as compared to 10% dimethyl sulfoxide (DMSO) alone. The proposed workflow from the preparation of core-shell capsules with self-assembled cellular structures to the cryopreservation appears to be a promising strategy for their off-the-shelf availability.
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Wróblewska-Krepsztul, Jolanta, Tomasz Rydzkowski, Iwona Michalska-Pożoga, and Vijay Kumar Thakur. "Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning." Nanomaterials 9, no. 3 (March 10, 2019): 404. http://dx.doi.org/10.3390/nano9030404.

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Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications. In this direction, some progress has been made in extending use of the electrospinning process towards fiber formation based on biopolymers and organic compounds for the preparation of novel packaging materials. Electrospinning can be used to create nanofiber mats characterized by high purity of the material, which can be used to create active and modern biomedical and pharmaceutical packaging. Intelligent medical and biomedical packaging with the use of polymers is a broadly and rapidly growing field of interest for industries and academia. Among various polymers, alginate has found many applications in the food sector, biomedicine, and packaging. For example, in drug delivery systems, a mesh made of nanofibres produced by the electrospinning method is highly desired. Electrospinning for biomedicine is based on the use of biopolymers and natural substances, along with the combination of drugs (such as naproxen, sulfikoxazol) and essential oils with antibacterial properties (such as tocopherol, eugenol). This is a striking method due to the ability of producing nanoscale materials and structures of exceptional quality, allowing the substances to be encapsulated and the drugs/ biologically active substances placed on polymer nanofibers. So, in this article we briefly summarize the recent advances on electrospinning of biopolymers with particular emphasis on usage of Alginate for biomedical and pharmaceutical applications.
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Ouyang, Liliang, James P. K. Armstrong, Yiyang Lin, Jonathan P. Wojciechowski, Charlotte Lee-Reeves, Daniel Hachim, Kun Zhou, Jason A. Burdick, and Molly M. Stevens. "Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks." Science Advances 6, no. 38 (September 2020): eabc5529. http://dx.doi.org/10.1126/sciadv.abc5529.

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A major challenge in three-dimensional (3D) bioprinting is the limited number of bioinks that fulfill the physicochemical requirements of printing while also providing a desirable environment for encapsulated cells. Here, we address this limitation by temporarily stabilizing bioinks with a complementary thermo-reversible gelatin network. This strategy enables the effective printing of biomaterials that would typically not meet printing requirements, with instrument parameters and structural output largely independent of the base biomaterial. This approach is demonstrated across a library of photocrosslinkable bioinks derived from natural and synthetic polymers, including gelatin, hyaluronic acid, chondroitin sulfate, dextran, alginate, chitosan, heparin, and poly(ethylene glycol). A range of complex and heterogeneous structures are printed, including soft hydrogel constructs supporting the 3D culture of astrocytes. This highly generalizable methodology expands the palette of available bioinks, allowing the biofabrication of constructs optimized to meet the biological requirements of cell culture and tissue engineering.
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Dissertations / Theses on the topic "Alginate-encapsulated structures"

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Gryshkov, O., V. Mutsenko, M. Tymkovych, D. Tarusin, V. Sirotinskaya, I. Braslavsky, О. Г. Аврунін, and B. Glasmacher. "Advances in cryopreservation of alginate-encapsulated stem cells and analysis of cryopreservation outcome." Thesis, Інститут проблем кріобіології та кріомедицини НАН України, 2018. http://openarchive.nure.ua/handle/document/8338.

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Conference papers on the topic "Alginate-encapsulated structures"

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Lee, Seung-Jae, Byung Kim, Geunbae Lim, Jong-Won Rhie, Hyun-Wook Kang, and Dong-Woo Cho. "Development of Three-Dimensional Alginate Encapsulated Chondrocyte Hybrid Scaffolds Using Microstereolithography." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31056.

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Hydrogels are useful materials because of their chemical similarity to extracellular matrix and their ability to rapidly diffuse hydrophilic nutrients and metabolites. Using rapid prototyping (RP) methods, we fabricated freeform three-dimensional (3-D) scaffolds with chondrocytes encapsulated in an alginate hydrogel. The 3-D hybrid scaffold was developed as combination of two components, a TMC/TMP framework and an alginate hydrogel within an encapsulation of chondrocytes. To develop 3-D hybrid scaffolds, we employed a microstereolithography system. The biodegradable, photo-polymerizable liquid prepolymer was prepared by the polymerization of trimethylene carbonate (TMC) with trimethylolpropane (TMP), and subsequently end-capped with an acrylate group. The meshed framework of scaffolds withstood mechanical loading effectively. The line depth and line width could be controlled by varying laser power, scan path, and scan speed. Results of cell culture indicate that the biomimetic nature of these encapsulated chondrocyte scaffolds effectively retain the phenotypic function of chondrocytes within the scaffold structure. The proposed 3-D hybrid scaffolds can be used for cartilage regeneration.
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Forghani, A., L. Garber, C. Chen, R. Devireddy, J. Pojman, and D. Hayes. "In Situ Polymerization of PEGDA Foam for Bone Defects." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51235.

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The purpose of this study is to develop a novel bone replacement using in situ polymerization of thiol-acrylate with adipose tissue derived adult stem cells (ASCs). Specifically, Poly(ethylene glycol) diacrylate-co-trimethylolpropane tris (3-mercaptopropionate) (PEGDA-co-TMPTMP) was synthesized with 10% Hydroxyapatite (HA) foam by an amine-catalyzed Michael addition reaction. Initial characterization studies were performed to determine the temperature profile during the exothermic reaction showing a peak temperature of 50°C. To prevent hyperthermic cell damage and death during the exothermic polymerization procedure, the hASCs were encapsulated in alginate. Characterization of the 3-D structure and interconnectivity of pores in the polymeric foam scaffolds were performed using FIB-SEM and Micro-CT showing uniform distribution of HA. Cell viability experiments within the polymeric scaffold were performed using Vybrant® MTT cell profileration method, as well as fluorescent dyes: Calcein-AM (live) and Ethidium homodimer-1 (dead) showing viability of cells inside the samples.
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Reza, Anna T., and Steven B. Nicoll. "Chemically Defined Medium With TGF-β3 Enhances Matrix Elaboration by Nucleus Pulposus Cells Encapsulated in Novel Photocrosslinked Carboxymethylcellulose Hydrogels." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206199.

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Back pain is a significant clinical concern often attributed to degeneration of the intervertebral disc (IVD) and the associated dehydration of the nucleus pulposus (NP) [1]. The NP is a gel-like tissue at the center of the disc, rich in proteoglycans and type II collagen that functions to resist compressive forces through the generation of a hydrostatic swelling pressure [2]. Tissue engineering strategies may provide a viable NP replacement therapy as an alternative to current surgical procedures. However, several factors including medium formulation and scaffold selection can affect construct maturation [3]. For example, transforming growth factor-beta 3 (TGF-β3) has been shown to enhance the functional properties of tissue engineered cartilage constructs, with more pronounced results observed in serum-free conditions [3]. NP cells are commonly cultured in ionically crosslinked alginate hydrogels to maintain their phenotypic properties; however, these scaffolds have been shown to lose structural integrity over time, creating a need for an alternative biomaterial [4]. Therefore, the objective of this study was to examine the effects of medium formulation on NP cells encapsulated in novel photocrosslinked carboxymethylcellulose (CMC) hydrogels.
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