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Adani, Roberto. "Professor Alessandro Caroli (1933–2021)." Journal of Hand Surgery (European Volume) 47, no. 3 (December 13, 2021): 335. http://dx.doi.org/10.1177/17531934211064213.
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Picasso, Riccardo, Federico Pistoia, Federico Zaottini, Sonia Airaldi, Maribel Miguel Perez, Michelle Pansecchi, Luca Tovt, et al. "High-resolution ultrasound of spigelian and groin hernias: a closer look at fascial architecture and aponeurotic passageways." Journal of Ultrasonography 21, no. 84 (March 8, 2021): e53-e62. http://dx.doi.org/10.15557/jou.2021.0008.
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De Coro, Alessandra. "Carla De Gennaro (1946-2021) e Giuseppe Nonini (1944-2021)." STUDI JUNGHIANI, no. 55 (August 2022): 115–18. http://dx.doi.org/10.3280/jun55-2022oa14071.
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Sardelli, Alessandro. "‘When a Dream Vanishes’: Edward Gordon Craig in Florence." New Theatre Quarterly 5, no. 18 (May 1989): 140–51. http://dx.doi.org/10.1017/s0266464x00003031.
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When Gordon Craig settled in Florence before the First World War, he found himself amidst a flourishing avant-garde artistic community. which he regarded with some caution. Between the staging of Rosmersholm with Duse in 1906 and the closing of his short-lived theatre school at the Goldoni Arena in 1914, he also conducted a correspondence with the eclectic cosmopolitan Carlo Placci – a previously unpublished source on which Alessandro Sardelli has drawn to illuminate Craig's Florentine years, during which his influential journal The Mask made its earliest appearance, and Craig also developed the idea of his adjustable screens, first employed during his Moscow collaboration with Stanislavski on Hamlet.
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Lupo, Eleonora, and Gennaro Postiglione. "Inventario: Everything is Project, by Beppe Finessi, Artemio Croatto, Carlo Urbinati and Alessandro Vecchiato." Interiors 3, no. 1-2 (March 2012): 169–71. http://dx.doi.org/10.2752/204191212x13232577462772.
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Lacaita, Carlo G. "Da una celebrazione all'altra. Temi e problemi di esegesi cattaneana." RIVISTA DI STORIA DELLA FILOSOFIA, no. 3 (September 2021): 409–20. http://dx.doi.org/10.3280/sf2021-003002.
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Starting from the first centenary of Carlo Cattaneo's birth in 1901, the Author reviews the publication of his works in concomitance with the interpretation and diffusion of his thinking. From the first ample collection of writings, down to Bertani and other friends, to the anthology by Gaetano Salvemini, from Alessandro Levi's monograph to the interpretations of Norberto Bobbio and Luigi Ambrosoli, the article shows the interweaving between the exegesis and the piecing together of Cattaneo's dispersed works, the complete retrieval of which is being undertaken by the Italo-Swiss Committee set up in 1946. It ends with the new national edition of his works, which on the occasion of the 150th anniversary of his death in 2019 saw the publication of the fourth volume of his Lettere, the eighth volume in the entire collection.
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Redazione, RGI. "Informazione bibliografica." RIVISTA GEOGRAFICA ITALIANA, no. 3 (September 2022): 121–54. http://dx.doi.org/10.3280/rgioa3-2022oa14594.
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Augustin Berque, Essere umani sulla terra. Principi di etica dell'ecumene (Cristiana Zorzi) João Pedro Stedile, a cura di, Experiências historicas de reforma agrária no mundo (Teresa Isenburg) Reza Negarestani, Cyclonopedia. Complicità con materiali anonimi (Andrea Pase) Johny Pitts, Afropean – Mari D'Agostino, Noi che siamo passati dalla Libia. Giovani in viaggio fra alfabeti e multilinguismo (Angelo Turco)  Marco Aime, Andrea de Georgio, Il grande gioco del Sahel. Dalle carovane di sale ai Boeing di cocaina (Mariasole Pepa)  Stefano Malatesta, Marcella Schmidt di Friedberg, Shahida Zubair, David Bowen, Mizna Mohamed, Atolls of the Maldives. Nissology and Geography (Federica Letizia Cavallo)  Valerio Calzolaio, Isole Carcere – Geografia e Storia (Marco Nocente)  Emanuela Casti, Fulvio Adobati, Ilia Negri, a cura di, Mapping the epidemic. A systemic Geography of Covid-19 in Italy (Federica Burini) Alessandro Coppola, Matteo Del Fabbro, Arturo Lanzani, Gloria Pessina, Federico Zanfi, a cura di, Ricomporre i divari. Politiche e progetti territoriali contro le disuguaglianze e per la transizione ecologica (Carlo Salone) Filippo Barbera, Antonio De Rossi (a cura di), Metromontagna. Un progetto per riabitare l'Italia (Silvy Boccaletti)
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RGI, Redazione. "Informazione bibliografica." RIVISTA GEOGRAFICA ITALIANA, no. 1 (April 2021): 113–67. http://dx.doi.org/10.3280/rgioa1-2021oa11648.
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Augustin Berque, Ecumene. Introduzione allo studio degli ambienti umani, a cura di Marco Maggioli, traduzione di Claudio Arbore, Simone Gamba e Marco Maggioli. Milano, Mimesis, 2019.Tim Cresswell, Maxwell Street. Writing and Thinking Place. Chicago and London, University of Chicago Press, 2019.John van Wyhe, Wanderlust. The amazing Ida Pfeiffer, the First Female Tourist. Singapore, NUS Press, 2019.Lorenzo Bagnoli, Christian Garnier, géographe-geografo, 1872-1898. Parigi, Société de Géographie, 2020.Margherita Cisani, Paesaggi e Mobilità. Strumenti per le geografie del quotidiano. Milano, FrancoAngeli open access, 2020.Marcello Tanca, Geografia e fiction. Opera, film, canzone, fumetto. Milano, FrancoAngeli, 2020.Hamzah Muzaini, Claudio Minca, After heritage, critical perspectives on heritage from below. Cheltenham, UK - Northampton, MA, USA, Edward Elgar Publishing, 2020.Bernard Floris, Luc Gwiazdzinski, a cura di, Sur la vague jaune. L'utopie d'un rond-point. Seyssinet-Pariset, Elya Éditions, 2019.Maitane Ostolaza, La terre des basques: naissance d'un paysage (1800-1936). Rennes, PUF, 2018.Anna Casaglia, Nicosia beyond partition. Complex Geographies of a Divided City. Milano, Unicopli, 2020.Stelio Mangiameli, Andrea Filippetti, Fabrizio Tuzi, Claudia Cipolloni, Prima che il Nord somigli al Sud. Le Regioni tra divario e asimmetria. Soveria Mannelli, Rubbettino, 2020.Annibale Salsa, I paesaggi delle Alpi. Un viaggio nelle terre alte tra filosofia, natura e storia, Prefazione di Gianluca Cepollaro e Alessandro de Bertolini. Roma, Donzelli, 2019.Carlo Perelli, Il telaio e la trama. Reti di comunità e azione territoriale in Sardegna. Milano, FrancoAngeli, 2020.Carlo Cellamare, Francesco Montillo, a cura di, Periferia. Abitare a Tor Bella Monaca. Roma, Donzelli, 2020.Maria Ronza, Dalla via Appia alla città policentrica: Caserta e il suo territorio. Trieste, EUT - Edizioni Università di Trieste, 2019.
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Olivieri, G., F. Ceccarelli, A. Lo Presti, S. Angeletti, C. Perricone, G. Iaiani, L. De Florio, et al. "THU0281 EXPLORING THE GENETIC DIVERSITY OF STAPHYLOCOCCUS AUREUS IN PATIENTS AFFECTED BY SYSTEMIC LUPUS ERYTHEMATOSUS: ASSOCIATION WITH DISEASE-RELATED FEATURES AND ACTIVITY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 367.1–368. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3592.
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Background:Infective factors play a central role in autoimmune diseases pathogenesis. It is possible to speculate that the host genotype could interact with genetic background of infective agents. We previously evaluated a large SLE cohort, observing the association between theS. Aureus(SA) carriage status and presence of a more active disease in terms of autoantibodies positivity.Objectives:We evaluated epidemiological, molecular characterization, genetic diversity and evolution of SA isolated from SLE patients by means of phylogenetic analysis.Methods:Consecutive SLE patients (ACR 1997 criteria) were enrolled: clinical/laboratory data were collected and nasal swab for SA identification was performed. On the basis of translation elongation factor (tuf) gene, a phylogenetic analysis was performed to investigate phylogenetic relationships and to assess significant clades in patients with persistent carriage status (nasal swab positive in two consecutive evaluation, performed 1 week apart). The first dataset was composed by seven SA tuf gene isolated from non-SLE individuals from different countries (downloaded from the GenBank database,https://www.ncbi.nlm.nih.gov/nucleotide/) and tuf gene SA collected from SLE patients enrolled in the present study.Results:We enrolled 118 patients (M/F 10/198; median age 45.5 years, IQR 13,2; median disease duration 120 months, IQR 144). Skin involvement is the most frequent disease manifestation (86 patients, 72.9%), followed by joint involvement (78 patients, 66.1%). Twenty-four patients (20.3%) were SA carriers (SA+), three of them resulted MRSA. SA+ patients showed a significantly higher prevalence of joint involvement (79.2%versus62.7%, P=0.01) and anti-dsDNA positivity (75.0%versus55.3%, P=0.004). Moreover, SA+ SLE showed a more active disease, in terms of SLEDAI-2k values [SA+: median 2 (IQR 3.75)versusSA-: median 0 (IQR 2), P=0.04). The phylogenetic analysis has been restricted on the 21 non-MRSA SA+ patients. The maximum likelihood phylogenetic tree of the first dataset revealed a statistically supported larger clade (A, N=17) and a smaller one (B, N=4; figure 1A). SLE patients located in the clade A showed a significantly higher prevalence of joint involvement (88.2%) in comparison with clade B (50.0%, P<0.0001) and SA- (62.7%, P<0.0001, figure 2B). Moreover, haematological manifestations were significantly more frequent in clade A patients (64.7%) compared with B (50.0%, P=0.004, figure 2C).Conclusion:The results of the present study confirmed the association between SA carriage status and disease activity, in terms of SLEDAI-2k values and anti-dsDNA positivity. The phylogenetic analysis ontufgene show a clustering ofSA+patients in two major clade (A and B). Interestingly thetufgenotype of clade A is significantly associated with a specific disease phenotype, characterized by joint involvement and positivity for anti-dsDNA. These findings support the hypothesis that bacterial genetic variants may be associated with specific disease features.References:[1]Rigante et al. Int J Mol Sci. 2015;[2]Wertheim et al Lancet Infect Dis. 2005;[3]Conti et al Arthritis Res Ther 2016;[4]Tong et al Clin Microbiol Rev. 2015;[5]Rhee et al Infect Control Hosp Epidemiol. 2015Disclosure of Interests:Giulio Olivieri: None declared, Fulvia Ceccarelli: None declared, Alessandra Lo Presti: None declared, silvia angeletti: None declared, Carlo Perricone: None declared, Giancarlo Iaiani: None declared, Lucia De Florio: None declared, francesca antonelli: None declared, Luigino Amori: None declared, Cristina Garufi: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Speakers bureau: Lilly, BMS, Celgene, cristiano Alessandri: None declared, Guido Valesini: None declared, Massimo Cicozzi: None declared, Fabrizio Conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Murgia, Gisella. "Sardegna tra leggenda e realtà: ‘Sa femmina accabadora’, colei che dà la buona morte, nelle immagini e nelle parole di alcuni autori sardi." Italianistica Debreceniensis 24 (December 1, 2018): 77–84. http://dx.doi.org/10.34102/italdeb/2018/4662.
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The term accabadora refers to a woman entrusted with the task of facilitating the passing of the dying people. She killed for pity, called by the families of the patients to relieve their sufferings on their own deathbed. Basically, she practiced a sort of ante litteram euthanasia. But that carried out by the woman was also a necessary action for the survival of relatives who, most of the time, did not have the necessary resources to alleviate the sufferings of the kinsmen. Furthermore, in small towns, the doctor was often several days away on horseback. While the accabadora took life away, on the other hand, she gave it back, helping the women of her community to give birth. Everyone in the village knew the activity of these women but all of them were silent. They were convinced that the work of the accabadora was a meritorious work because it took the burden of putting an end to the sufferings of the patient. They implicitly recognized in it a social utility. After outlining the figure of 'sa fèmmina practica', this report analyses some works by Sardinian authors who are interested in it. Above all, we will mention the novel by Michela Murgia, Accabadora (Campiello prize 2010); the film by Enrico Pau, L'accabadora; the novels L’ultima agabbadòra by Sebastiano Depperu and L'agabbadora. La morte invocata by Giovanni Murineddu; the short film Deu ci sia by Gianluca Tarditi, winner of the 2011 Golden Globe at 48th New York Film Festival; Ho visto agire s’accabadora by Dolores Turchi; Eutanasia ante litteram in Sardegna. Sa femmina accabadora by Alessandro Bucarelli and Carlo Lubrano and S’accabadora e la sacralità del femminino of Maria Antonella Arras.
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Stefanini, Ruggero. "Giacomo Devoto nel Centenario della nascita: Atti del Convegno "Giacomo Devoto e le Istituzioni" (Firenze, 24—25 ottobre 1997), edd. Carlo Alberto Mastrelli and Alessandro Parenti." Romance Philology 55, no. 2 (January 2002): 307–13. http://dx.doi.org/10.1484/j.rph.2.304483.
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Farneti, Fauzia. "Il quadraturismo in Pallazzo Pitti da Cosimo II a Cosimo III de' Medici." Varia Historia 24, no. 40 (December 2008): 369–86. http://dx.doi.org/10.1590/s0104-87752008000200002.
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Nei primi decenni del Seicento la pittura decorativa a Firenze risulta ancora legata all'ornamentazione tradizionale tardomanierista attuata nei modi di Alessandro Allori o di Bernardino Barbatelli detto il Poccetti. L'interesse per le novità e per l'aggiornamento dell'ambiente artistico fiorentino portarono il granduca Ferdinando II a chiamare a Firenze tra il 1636 ed il 1637 Pietro da Cortona, Angelo Michele Colonna e Agostino Mitelli. I due bolognesi completarono il ciclo pittorico celebrativo del governo di Ferdinando cui aveva dato inizio Giovanni da San Giovanni, con la decorazione delle tre sale di rappresentanza del quartiere estivo di palazzo Pitti realizzata tra il 1637 ed il 1641. L'intervento, condotto secondo il più moderno linguaggio barocco che vede la perfetta integrazione dell'illusionismo architettonico, che supera i limiti dello spazio reale, con le scene figurative, verrà a costituire nell'ambiente fiorentino un ineludibile modello di riferimento nella decorazione d'interni, soluzioni di grande modernità su cui si formerà Jacopo Chiavistelli e i giovani della sua scuola. Anche Giovan Carlo, fratello del granduca, nel 1637 diede inizio ad una serie di trasformazioni che si protrassero per oltre un ventennio, trasformando gli ambienti a lui assegnati in Pitti in veri e propri luoghi di delizie, decorati dagli artisti più significativi del momento quali ad esempio Angelo Michele Colonna, Agostino Mitelli, Pietro da Cortona, Jacopo Chiavistelli. Fu quest'ultimo frescante che con i suoi 'scolari', fin dagli anni Cinquanta fu attivo in palazzo Pitti, decorando a quadratura gli ambienti dei quartieri dei membri della famiglia granducale, ambienti che in gran parte sono andati perduti in quanto interessati dalle ristrutturazioni lorenesi e sabaude. Con i lavori commissionati dal gran principe Ferdinando si chiude in palazzo Pitti la grande stagione del quadraturismo barocco fiorentino.
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Moss, David. "Carlo Buzzi, Alessandro Cavalli and Antonio de Lillo (eds), Giovani verso il Duemila, Il Mulino, Bologna, 1997, 458 pp., ISBN 88-15-06216-5 pbk, 42,000 Lire." Modern Italy 6, no. 1 (May 2001): 83–84. http://dx.doi.org/10.1017/s1353294400008462.
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Kirkali, Ziya, and Ferran Algaba. "Rebuttal from Authors re: Carlo Terrone, Alessandro Volpe. The Role of Pathology for Clinical Decision-Making in Renal Cell Carcinoma is Increasing. Eur Urol 2007;51:1166–8." European Urology 51, no. 5 (May 2007): 1168–70. http://dx.doi.org/10.1016/j.eururo.2007.01.066.
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Fabris, Dinko. "Circolazione dell’opera italiana attraverso i teatri non europei del Mediterraneo: Il caso degli italiani al Cairo intorno alla prima dell’ Aida del 1871." Artigrama, no. 36 (December 9, 2022): 223–40. http://dx.doi.org/10.26754/ojs_artigrama/artigrama.2021368108.
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Per un secolo e mezzo, l’episodio della prima dell’Aida di Verdi al Cairo nel 1871 hacatturato l’attenzione degli studiosi, che non hanno mai esplorato sistematicamente il contestooperistico —allo stesso tempo locale e globalizzato— in cui quella vicenda si era inserita. Inrealtà l’Egitto stava vivendo una fase di grande interesse per l’opera e per i teatri all’europea,condivisa da molti altri territori dell’impero ottomano a cominciare dalla capitale Costantinopoli. Compagnie di cantanti italiani avevano già portato il repertorio più aggiornato dell’operaitaliana prima ad Alessandria e poi al Cairo e, negli stessi anni della produzione di Aida, unacompagnia era stata scritturata per una stagione di opere francesi e italiane, con la direzione diNicola De Giosa, compositore di scuola napoletana e primo vero direttore dell’orchestra del Teatrodi San Carlo. Come il prediletto di Verdi, Emanuele Muzio, anche De Giosa fu però scartato dalsovrintendente del teatro egiziano, che affidò la direzione di Aida a Bottesini. Alcuni frammentisuperstiti di documentazione consentono di intuire il peso della presenza degli artisti italianinella nascita del teatro d’opera vicereale al Cairo. Artisti e direttori itineranti, ma anche glialtri individui coinvolti nelle prime rappresentazioni di opere europee in Egitto, sono certamenteprotagonisti di una storia minore, ma che ci sembra interessante cominciare a ricostruire perinserire queste vicende di mobilità artistica in una più ampia rete dei teatri del Mediterraneo.
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Ceccarelli, F., G. Olivieri, L. Dominici, A. I. Celia, E. Cipriano, C. Garufi, S. Mancuso, et al. "OP0204 LUPUS COMPREHENSIVE DISEASE CONTROL IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: APPLICATION OF A NEW INDEX." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 127.1–127. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4560.
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Background:The main outcomes in SLE patients management are represented by the remission achievement and chronic damage prevention. Even though activity and damage are intimately connected, to date indices including both these outcomes are not available.Objectives:In the present study, we aimed at assessing the application of a new index, the Lupus comprehensive disease control (LupusCDC), including disease activity and chronic damage progression.Methods:We performed a longitudinal analysis, including SLE patients according to ACR 1997 criteria, followed-up in the period between January 2014 and December 2018, and with at least one visit per year. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2K) and three different remission levels were evaluated, as reported in Table 1 (1).Table 1.Remission levels considered in the study (1).Remission levelDefinitionComplete Remission(CR)No clinical and serological activity (SLEDAI-2K=0) in corticosteroid-free and immunosuppressant-free patients (antimalarials allowed)Clinical remission off-corticosteroids(ClR-GCoff)Serological activity with clinical quiescent disease according to SLEDAI-2K in corticosteroid-free patients (stable immunosuppressive therapy and antimalarials allowed)clinical remission on-corticosteroids(ClR-GCon)Clinical quiescent disease according to SLEDAI-2K in patients on prednisone 1–5 mg/day (stable immunosuppressants and antimalarials allowed)Chronic damage was registered according to SLICC damage index (SDI). All the patients were evaluated at baseline (T0) and every 12 months (T1, T2, T3, T4). At each time-point, we calculated the prevalence of LupusCDC, defined as remission achievement plus absence of chronic damage progression in the previous one year. We calculated this outcome including separately the different remission levels.Results:According with inclusion criteria, 172 SLE patients were evaluated in the present analysis [M/F 16/156, median age 49 years (IQR 16.7), median disease duration 180 months (IQR 156)]. At first assessment, we observed a mean±SD SDI value of 0.7±1.1. In details, 56 patients (32.5%) showed damage in at least one organ/system and the presence of damage was significantly associated with age (p<0.0001, r=0.3) and disease duration (p=0.0003, r=0.3). During the follow-up, we observed a significant increase in SDI values compared with T0 (T1: mean±DS 0.8±1.3, p<0.0001; T2: 0.8±1.4, p<0.0001; T3: 0.9±1.4 p=0.0001; T4: 1.0±1.5 p<0.0001).In figure 1A and 1B we reported the proportion of patients achieving the different levels of remission and LupusCDC, respectively. In particular, the LupusCDC definition including CR was the most frequently detected in all time-points evaluated (T1: 18.0%; T2: 31.9%; T3: 27.9%; T4: 24.4%), with a significant difference at T2 [LupusCDC(CR)versusLupusCDC(ClR-GCoff), p=0.0002; LupusCDC(CR)versusLupusCDC(ClR-GCon) p=0.0002)], T3 [LupusCDC(CR)versusLupusCDC(ClR-GCoff), p=0.03; LupusCDC(CR)versusLupusCDC(ClR-GCon) p=0.006], T4 [LupusCDC(CR)versusLupusCDC(ClR-GCon), p=0.002]. No significant differences were found when comparing the prevalence of different remission levels and the prevalence of LupusCDC including the corresponding remission.Conclusion:In the present analysis we proposed for the first time a new index including disease activity and chronic damage, in order to evaluate the proportion of SLE patients reaching a comprehensive disease control. We found that CR is most frequently associated with the absence of damage progression.References:[1]Zen M et al. Ann Rheum Dis 2017.Disclosure of Interests:Fulvia Ceccarelli: None declared, Giulio Olivieri: None declared, Lorenzo Dominici: None declared, Alessandra Ida Celia: None declared, enrica cipriano: None declared, Cristina Garufi: None declared, Silvia Mancuso: None declared, Francesco Natalucci: None declared, Valeria Orefice: None declared, Carlo Perricone: None declared, Carmelo Pirone: None declared, viviana antonella pacucci: None declared, Francesca Morello: None declared, Simona Truglia: None declared, Francesca Miranda: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, cristiano alessandri Grant/research support from: Pfizer, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Monti, S., L. Dagna, C. Campochiaro, A. Tomelleri, G. Zanframundo, C. Klersy, F. Muratore, et al. "FRI0212 THE ROLE OF AGE ON THE CLINICAL PRESENTATION AND RELAPSE RATES IN A LARGE COHORT OF 720 PATIENTS WITH GIANT CELL ARTERITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 689.1–690. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3779.
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Background:Giant cell arteritis (GCA) is the most frequent systemic vasculitis after the age of 50 years old. Recent interest in the processes of immune and vascular aging have been proposed as a disease risk factor. Data on the impact of age at diagnosis of GCA on the clinical course of the disease are scarceObjectives:To assess the role of age at diagnosis of GCA on the risk and time to relapseMethods:Centres participating in the Italian Society of Rheumatology Vasculitis Study Group retrospectively enrolled patients with a diagnosis of GCA until December 2019. The cohort was divided in tertiles according to age at diagnosis (≤ 72; 73-79; > 79 years old). Negative binomial regression was used to assess the relapse rate according to age groups, and Cox regression for time to first relapse.Results:Of 720 patients enrolled in 14 Italian reference centres, 711 had complete follow-up data (female 50%; mean age 75±7). Median follow-up duration was 34 months (IQR 16;70). Patients in the older group at diagnosis (> 79 years) had more frequent visual loss compared to the 73-79 and ≤ 72 age groups (31% vs 20% vs 7%; p<0.001), but lower rates of general symptoms (56% vs 70% vs 77%; p<0.001). Large-vessel (LV)-GCA was less frequent in the older group (18% vs 22% vs 43%; p<0.001). At least one relapse occurred in 47% of patients. Median time to relapse was 12 months (IQR 6;23). Age did not influence the rate of relapses [18 per 100 persons/years (95%CI 15;21) vs 19 (95% CI 17;22) vs 19 (95%CI 17;22)], nor the time to first relapse (Figure 1). LV-GCA, presentation with significantly elevated c-reactive protein (> 50 mg/L) and general symptoms were independent predictors of relapse.Conclusion:Age at diagnosis of GCA influenced the clinical presentation and risk of ischaemic complications, but did not affect the relapse rate during follow-up. LV-GCA occurred more frequently in younger patients and was an independent predictor of relapse risk, highlighting the need for a correct characterization of the clinical subtype at the early stages of disease.Disclosure of Interests:Sara Monti: None declared, Lorenzo Dagna Grant/research support from: Abbvie, BMS, Celgene, Janssen, MSD, Mundipharma Pharmaceuticals, Novartis, Pfizer, Roche, SG, SOBI, Consultant of: Abbvie, Amgen, Biogen, BMS, Celltrion, Novartis, Pfizer, Roche, SG, and SOBI, Corrado Campochiaro Speakers bureau: Novartis, Pfizer, Roche, GSK, SOBI, Alessandro Tomelleri: None declared, Giovanni Zanframundo: None declared, Catherine Klersy: None declared, Francesco Muratore: None declared, Luigi Boiardi: None declared, Roberto Padoan: None declared, Mara Felicetti: None declared, Franco Schiavon: None declared, Milena Bond: None declared, Alvise Berti: None declared, Roberto Bortolotti: None declared, Carlotta Nannini: None declared, Fabrizio Cantini: None declared, Alessandro Giollo: None declared, Edoardo Conticini: None declared, angelica gattamelata: None declared, Roberta Priori: None declared, Luca Quartuccio Consultant of: Abbvie, Bristol, Speakers bureau: Abbvie, Pfizer, Elena Treppo: None declared, Giacomo Emmi: None declared, Martina Finocchi: None declared, Giulia Cassone: None declared, Ariela Hoxha Speakers bureau: Celgene, UCB, Novartis, Sanofi, Werfen, Rosario Foti Consultant of: lilly, sanofi, MSD, Janssen, Abbvie, BMS, celgene, roche, Speakers bureau: lilly, sanofi, MSD, Janssen, Abbvie, BMS, celgene, roche, Michele Colaci: None declared, Roberto Caporali Consultant of: AbbVie; Gilead Sciences, Inc.; Lilly; Merck Sharp & Dohme; Celgene; Bristol-Myers Squibb; Pfizer; UCB, Speakers bureau: Abbvie; Bristol-Myers Squibb; Celgene; Lilly; Gilead Sciences, Inc; MSD; Pfizer; Roche; UCB, Carlo Salvarani: None declared, Carlomaurizio Montecucco: None declared
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Campaner, Raffaella. "Maria Carla Galavotti and Alessandro Pagnini, Eds., Experience, Reality, and Scientific Explanation: Essays in Honour of Merrilee and Wesley Salmon. Dordrecht: Kluwer Academic Publishers, 1999, cloth $114.00. ISBN: 0 7923 5497 4." British Journal for the Philosophy of Science 51, no. 4 (December 1, 2000): 941–45. http://dx.doi.org/10.1093/bjps/51.4.941.
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Signorino, Rodolfo. "Marcella Corsi, Jan Kregel, and Carlo D’Ippoliti, eds., Classical Economics Today: Essays in Honor of Alessandro Roncaglia (London and New York: Anthem Press, 2018), pp. xi + 262, £70.00/$115.00 (hardcover). ISBN: 9781783087501." Journal of the History of Economic Thought 41, no. 03 (May 31, 2019): 438–42. http://dx.doi.org/10.1017/s1053837218000299.
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Dufour, Richard. "Carlo Natali, ed., Alessandro d’Afrodisia. Il destino. Trattato sul destino e su ciò dipende da noi. Dedicato agli imperatori (seconda edizione riveduta). Sankt Augustin, Academia Verlag (coll. « International Aristotle Studies », 5), 2009, 272 p." Laval théologique et philosophique 67, no. 2 (2011): 397. http://dx.doi.org/10.7202/1007023ar.
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Ariani, A., E. Bravi, M. De Santis, V. Hax, S. Parisi, F. Lumetti, F. Girelli, et al. "OP0063 QUANTITATIVE COMPUTED TOMOGRAPHY PREDICTS 10-YEAR MORTALITY IN INTERSTITIAL LUNG DISEASE RELATED TO SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 42.1–42. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2239.
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Background:Interstitial lung disease (ILD) is the main cause of death in Systemic Sclerosis (SSc). Chest CT is the gold standard in detecting ILD although it is not easy to understand its prognostic value. ILD qualitative assessment is almost worthless. Goh et al. semi quantitative score of ILD extent is related to mortality risk but it is burdened by relevant inter/intra-readers variability. An operator independent algorithm based on voxel-wise analysis proved to identify SSc patients with an increased risk of mortality according to prediction models.Objectives:To verify if quantitative analysis of chest CT (QCT) predict 10 years-mortality in SSc patients.Methods:SSc patients with availability of a chest CT were enrolled in 13 different centers. The CT voxel-wise analysis with a free software (www.horosproject.com) provided QCT indexes: kurtosis, skewness, mean lung attenuation and standard deviation. Patients characteristics, autoimmune profile and pulmonary function test were collected. The follow-up interval lasted from the date of chest CT to the one of the last visit or death. Each QCT index cutoff, established in a previous study (1), clustered patients in two groups. Kaplan-Meier analysis estimated and compared survival in the above mentioned groups. p < 0.05 was considered statistically significant.Results:Five hundred sixty three SSc patients were enrolled (35938 patient-months); 52.4% had ILD detectable at CT scan. For each QCT index cutoff the cohort was split in two subgroups without differences in terms of sex, age, disease duration, autoimmune profile. All QCT indexes’ cutoff selected subgroups with statistically different survival rate (e.g in Figure 1).Figure 1Conclusion:QCT can arise as the new gold standard in identifying SSc patients with poor prognosis. The real possibility to stratify SSc subjects according mortality risk will have a pivotal role in ILD treatment decisional process with the incoming anti-fibrotic drugs.References:[1]Ariani A et al. Rheumatology 2017Disclosure of Interests:Alarico Ariani: None declared, Elena Bravi: None declared, Maria De Santis: None declared, Vanessa Hax: None declared, Simone Parisi: None declared, Federica Lumetti: None declared, Francesco Girelli: None declared, Marta Saracco: None declared, Fabio De Gennaro: None declared, Alessandro Giollo: None declared, Masen Abdel Jaber: None declared, Francesco Bozzao: None declared, Mario Silva: None declared, Maria Chiara Ditto: None declared, Claudia Lomater: None declared, Flavio Mozzani: None declared, Daniele Santilli: None declared, eleonora Di Donato: None declared, Andrea Becciolini Speakers bureau: Sanofi-Genzyme, UCB and AbbVie, Francesco Pucciarini: None declared, Lorenzo Canziani: None declared, Flavio Cesare Bodini: None declared, eugenio arrigoni: None declared, M Bredemeier: None declared, Rafael Mendonça da Silva Chakr: None declared, Amelia Spinella: None declared, Luca Idolazzi: None declared, Roberto Bortolotti: None declared, Paola Tomietto: None declared, Elisa Baratella: None declared, Saverio Tollot: None declared, Dilia Giuggioli: None declared, Fabio Fischetti: None declared, Enrico Fusaro: None declared, Nicola Sverzellati: None declared, Carlo Alberto Scirè: None declared
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Gatto, M., R. Depascale, A. Tincani, G. Emmi, S. Scarpato, F. Conti, M. Govoni, et al. "AB0441 PREDICTORS OF CLASI RESPONSE OVER TIME IN A MULTICENTRIC REAL LIFE COHORT OF SLE PATIENTS TREATED WITH BELIMUMAB." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1348.2–1349. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3867.
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BackgroundOver 80% of patients affected with SLE experience skin involvement. The anti-BLyS drug belimumab was shown effective in ameliorating mucocutaneous SLE manifestations in clinical trials and real-life studies. Cutaneous response is quantified through the CLASI (cutaneous lupus erythematosus area and severity index). Clinically relevant improvements are defined as decreases of ≥50% (CLASI50) or 70% (CLASI70) from baseline values.ObjectivesTo assess rates and predictors of CLASI50 and CLASI70 in the Berliss multicentric SLE cohort1 of patients treated with belimumab.MethodsBaseline and ongoing features of patients with baseline active skin involvement (CLASI>0) were assessed in relationship to the chosen outcomes CLASI50 and CLASI70 at 24 and 52 weeks. A subanalysis on patients with CLASI≥5 was as well conducted. Logistic regression was employed to identify predictors of response.Results172 patients displayed skin involvement at baseline (CLASI>0). Of those, 124 displayed at least a 12-month-follow-up and were included in the analysis. Seventy-seven (62.1%) patients reached CLASI50 at 24 weeks and 91 (77.8%) at 52 weeks; 87 (70.2%) reached CLASI70 at 24 and 99 (79.8%) at 52 weeks. Baseline predictors of CLASI50 at 24 weeks were CLASI-damage (CLASI-d) (OR [95%CI], p; 0.79 [0.65-0.98] 0.03) and disease duration (0.93[0.86-0.99], 0.011). No baseline predictors of CLASI70 at 24 weeks emerged, however having achieved a CLASI50 response at 24 weeks portended CLASI50 and 70 response through week 52 (p<0.01, Table 1). In the subgroup of patients with CLASI≥5, longer disease and increased CLASI-d at baseline confirmed as negative predictors of CLASI50 at 24 weeks. In this subset, use of antimalarials and active smoking at baseline predicted CLASI70 at 24 weeks (Table 1).Table 1.Predictors of CLASI-A Response at Week 24 and 52 by Baseline CLASI-A at 50% and 70% Response ThresholdsTimepointOutcomeVariableOR[95%CI] pCLASI>024 weeksCLASI50CLASI-d0.79 [0.65-0.98] 0.030Disease duration0.93[0.86-0.99], 0.011CLASI70CLASI-d0.93 [0.74-1.16], 0.51Disease duration0.97 [0.97-1.02], 0.1852 weeksCLASI50CLASI50 at 24 weeks14.3[4.88-44.42], <0.001CLASI70CLASI50 at 24 weeks6.22 [2.00-19.34], 0.002CLASI≥524 weeksCLASI50CLASI-d0.72 [0.53-0.98], 0.037Disease duration0.93 [0.66-1.00], 0.071CLASI70Antimalarials6.61 [1.20-36.29] 0.032Smoking0.15 [0.03-0.83], 0.03452 weeksCLASI50CLASI50 at 24 weeks22.0 [2.47-196.05], 0.006CLASI70CLASI50 at 24 weeks1.24 [0.06-25.08], 0.88CLASI, cutaneous lupus erythematosus area and severity index; CLASI-d, CLASI damage; CLASI50 and CLASI70: decrease ≥50% or ≥70% in CLASI from baseline. OR and 95%CIs are estimated using a logistic regression model with stratification factors as covariates (SLEDAI-2K at baseline, baseline prednisone dosage).ConclusionEarlier use of belimumab favors achievement of skin response among SLE patients and attainment of a prompt response predicts further response. Use of antimalarials reinforces while smoking hampers a more profound CLASI improvement over time.References:[1]Gatto M, et al. Arthritis Rheumatol. 2020 Aug;72(8):1314-1324Disclosure of InterestsMariele Gatto Speakers bureau: GSK, Grant/research support from: GSK, Roberto Depascale: None declared, Angela Tincani: None declared, Giacomo Emmi: None declared, Salvatore Scarpato: None declared, Fabrizio Conti: None declared, Marcello Govoni: None declared, Marta Mosca: None declared, Maria Gerosa: None declared, Enrica Bozzolo: None declared, Valentina Canti: None declared, Armando Gabrielli: None declared, Elisa Gremese: None declared, Salvatore De Vita: None declared, francesco ciccia: None declared, Carlo Salvarani: None declared, Maurizio Rossini: None declared, Paola Faggioli: None declared, Antonella Laria: None declared, Amato De Paulis: None declared, Roberto Gerli: None declared, Enrico Brunetta: None declared, Alessandro Mathieu: None declared, Carlo Selmi: None declared, Rossella De Angelis: None declared, Simone Negrini: None declared, Margherita Zen: None declared, Andrea Doria Speakers bureau: GSK, Eli Lilly, Roche, Grant/research support from: GSK, Luca Iaccarino Speakers bureau: GSK, Grant/research support from: GSK
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Ceccarelli, F., F. Natalucci, C. Perricone, E. Cipriano, C. Pirone, G. Olivieri, T. Colasanti, et al. "FRI0159 EROSIVE ARTHRITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS: APPLICATION OF CLUSTER ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 663–64. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4245.
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Background:Systemic Lupus Erythematosus (SLE) related arthritis has been traditionally defined non-erosive and then considered a minor manifestation. Thanks to the application of more sensitive imaging techniques, such as ultrasonography (US), erosive damage has been identified in up to 40% of SLE patients with joint involvement, suggesting the need for more appropriate treatment (1). Antibodies directed against citrullinated and carbamilated proteins (ACPA and anti-CarP, respectively) have been associated with erosive damage and then proposed as biomarkers for this more aggressive phenotype (2).Objectives:Here, we evaluated a large SLE cohort with joint involvement by using cluster analysis, in order to identify the disease phenotype associated with erosive arthritis.Methods:For this analysis, we enrolled consecutive SLE patients (ACR 1997 criteria) with a clinical history of joint involvement (arthritis/arthralgia). Clinical and laboratory data were collected in a standardized computerized electronically filled form, including demographics, past medical history with the date of diagnosis, co-morbidities, previous and concomitant treatments, serological status. The presence of rheumatoid factor (RF), ACPA and anti-CarP was investigated by ELISA test. Erosive damage was assessed by ultrasonography at level of metacarpophalangeal, proximal interphalangeal and metatarsophalangeal joints (MyLab Eight Exp, Esaote, Florence, Italy). Data have been analysed by hierarchic cluster analysis (SPSS program, IBM).Results:We enrolled 203 patients [M/F 12/191, median age 46.0 years (IQR 18); median disease duration 120.0 months (IQR 108)]. Erosive damage was identified in 53 patients (26.1%), all of them referring at least one episode of arthritis during disease course. Moving on autoantibodies status, RF was positive in 29.5%, anti-CarP in 28.5% and ACPA in 11.2%. The univariate analysis demonstrated a significant association between US-detected erosive damage and anti-CarP (p=0.01), ACPA (p=0.03), and renal manifestations (p=0.03). In Figure 1 we reported the dendrogram obtained from cluster analysis, allowing the identification of four cluster. Positivity for ACPA, anti-CarP, erosive damage, Jaccoud’s arthropathy and renal manifestations were allocated in the same cluster. Interestingly, RF resulted allocated in a different cluster, including ENA, anti-SSA and anti-SSB antibodies.Conclusion:The application of cluster analysis allowed the identification of a specific SLE phenotype, characterized by erosive damage, renal manifestations and positivity for anti-CarP and ACPA. We could speculate about the presence of a shared pathogenic mechanism, involving NETosis, contributing to nephritis and erosive arthritis.References:[1]Ceccarelli F et al. Semin Arthritis Rheum 2017[2]Ceccarelli F et al. Arthritis Res Ther 2018Disclosure of Interests:Fulvia Ceccarelli: None declared, Francesco Natalucci: None declared, Carlo Perricone: None declared, enrica cipriano: None declared, Carmelo Pirone: None declared, Giulio Olivieri: None declared, Tania Colasanti: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, cristiano alessandri Grant/research support from: Pfizer, Guido Valesini: None declared, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Roca, Maria Serena, federica iannelli, maria rita milone, veronica barile, cristina testa, tania moccia, carlo vitagliano, et al. "Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1840. http://dx.doi.org/10.1158/1538-7445.am2022-1840.
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Abstract INTRODUCTION: Metastatic pancreatic ductal adenocarcinoma (PDAC) represents an unmet clinical need because the lack of effective treatment strategies and a very poor prognosis. Here we propose a novel therapeutic strategy, based on the repurposing of valproic acid (VPA), a safe and generic drug with epigenetic modulating activity, and simvastatin (SIM), a widely used generic cholesterol lowering drug, in combination with the standard gemcitabine/nab-paclitaxel (GEM/NP) treatment in metastatic PDAC setting. METHODS: Synergistic anti-tumor effect of the combined treatment was assessed in PANC1, ASPC1, PANC28 and BxPC3 PDAC cell lines in vitro by evaluating combination index, apoptosis, clonogenic capability, tumor spheroids and fibroblasts/tumor cells microtissues growth. Antitumor effect was confirmed in vivo on heterotopic and orthotropic xenograft PANC1 models in athymic mice. Expression and functional role of TGF-β and downstream epithelial-to-mesenchymal-transition (EMT) markers were studied by Ingenuity pathway analysis (IPA), mRNA and protein expression and by cell migration scratch assay. RESULTS: We showed, both in vitro and in vivo, the ability of VPA/SIM combination, used at low dosages, to synergistically improve the anti-proliferative and pro-apoptotic effect of chemotherapy (GEM/NP). Mechanistically, VPA/SIM treatment, alone or in combination with chemotherapy, induced e-Cadherin and impaired vimentin and ZEB-1 expression, functionally linked to the synergistic inhibition of cell migration. In line, IPA highlighted a protein network connecting HDACs and HMGCR, the targets of VPA and SIM respectively, with the two main EMT markers. Notably, the most significantly cancer enriched features associated with this network were “migration of tumor cell lines”, “fibrosis” and “invasion of tumor cell lines”, and TGFβ emerged as a hierarchical dominant network- node. Indeed, VPA/SIM inhibited TGFβ transcription and TGFβ-regulated EMT gene expression in PDAC cells. Consistently we also observed a significant reduction of circulating TGFβ1 levels in mice treated with VPA/SIM in combination with GEM/NP, paralleled by a reduced fibrosis on PDAC xenograft tumor sections, confirming the involvement of TGFβ functional down-modulation in the mechanism of VPA/SIM antitumor synergistic interaction and chemo-sensitization. CONCLUSIONS: Overall, we proposed a novel combination strategy, based on two safe and generic drugs, able to sensitize a widely employed regimen in metastatic PDAC patients, that warrant further clinical evaluation. Citation Format: Maria Serena Roca, federica iannelli, maria rita milone, veronica barile, cristina testa, tania moccia, carlo vitagliano, fabiana tatangelo, di gennaro elena, antonio avallone, francesca bruzzese, alessandra leone, alfredo budillon. Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1840.
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Sambataro, G., D. Sambataro, F. Pignataro, N. Del Papa, M. Colaci, L. Malatino, A. Libra, et al. "FRI0260 NAILFOLD VIDEOCAPILLAROSCOPY IS A USEFUL TOOL TO RECOGNIZE SYSTEMIC SCLEROSIS AND IDIOPATHIC INFLAMMATORY MYOPATHIES IN INTERSTITIAL LUNG DISEASE PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 714.3–714. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4724.
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Background:Nailfold Videocapillaroscopy (NVC) is an essential tool for the assessment of Raynaud’s Phenomenon (RP) among the Scleroderma Spectrum Disorders (SSDs). Recently, NVC abnormalities have been associated with a diagnosis of Idiopathic Inflammatory Myopathies (IIMs), independently of the presence of RP (1). Moreover, both SSDs and IIMs are commonly associated with Interstitial Lung Disease (ILD), which is the main cause of mortality in these conditions.Objectives:To verify whether NVC may allow a better diagnostic classification in a cohort of patients with ILD followed by pulmonologists.Methods:361 patients affected by ILD were prospectively enrolled in a 30-months observational study. All these patients were clinically evaluated by rheumatologists and pulmonologists together and performed general blood tests, autoantibody research, chest High-Resolution Computed Tomography and NVC. The latter was considered positive in the presence of avascular areas or giant capillaries, and also the presence of Bushy Capillaries (BCs) was recorded.Results:NVC was positive in 17.7% of ILD patients, and a third of these patients did not present RP. Patients with NVC abnormalities had a diagnosis of definite Connective Tissue Disease in 78.1% of cases. NVC resulted decisive in 25% of patients with a final diagnosis of Systemic Sclerosis according to the ACR/EULAR 2013 criteria. The presence of BCs and/or NVC+ in ILD patients with normal serum levels of muscular enzymes was associated with amyopathic IIM (BCs= OR 3.9, 95CI 1.05-14.38, p=0.04; NVC+= OR 5, 95CI 1.29-19.3 p=0.02; BCs and/or NVC+= OR 5.41 95CI 1.24-23.48 p=0.02), regardless the presence of RP.Conclusion:NVC proved to be a valid tool in the correct assessment of ILD patients secondary to SSDs and amyopathic IIMs. Therefore, it could be considered in the diagnostic evaluation of patients affected by ILD, regardless of the presence of RP.References:[1]Sebastiani M et al. Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and possible clinical associations: results of a multicenter International Study.J Rheumatol2019; 46: 279-284Table 1.Comparison between ILD patients with and without NVC positivity..ItemsNVC+ patientsNVC- patientspNumber64297Mean Age (±SD)61.4±13.367.8±9.80.001Female%65.649.10.01RP%68.717.1<0.0001HRCT patterns%NSIP51.536.80.02OP3.18n.s.UIP-like31.1544.8n.s.DIP1.53.4n.s.LIP1.50.4n.s.Indeterminate10.96.7n.s.Final Diagnosis%SSDs45.31<0.0001IIMs256.4<0.0001Other CTDs6.213.5n.s.IPAF10.919.5n.s.IPF7.827.90.0007Legend:DIP: Desquamative Interstitial Pneumonia; HRCT: High Resolution Computed Tomography; IIMs: Idiopathic Inflammatory Myopathies, Poly/dermatomyositis, antisynthetase syndrome; IPAF: Interstitial Pneumonia with Autoimmune Features; IPF: Idiopathic Pulmonary Fibrosis; LIP: Lymphocytic Interstitial Pneumonia; NSIP: Nonspecific Interstitial Pneumonia; OP: Organising Pneumonia; RP: Raynaud’s Phenomenon; SSDs: Scleroderma Spectrum Disorders, Systemic Sclerosis + Mixed Connective Tissue Disease; UIP: Usual Interstitial Pneumonia.Disclosure of Interests:Gianluca Sambataro: None declared, Domenico Sambataro: None declared, Francesca Pignataro: None declared, Nicoletta Del Papa: None declared, Michele Colaci: None declared, Lorenzo Malatino: None declared, Alessandro Libra: None declared, Fabio Pino: None declared, Sebastiano Emanuele Torrisi Speakers bureau: Boehringer Ingelheim; F. Hoffmann-La Roche Ltd., Stefano Palmucci Consultant of: Boehringer Ingelheim, Speakers bureau: Boehringer Ingelheim, Delphi International Srl, and F. Hoffmann-La Roche Ltd., Lorenzo Cavagna: None declared, Carlo Vanchieri Grant/research support from: F. Hoffmann-La Roche Ltd., Consultant of: AstraZeneca, Boehringer Ingelheim, Chiesi, F. Hoffmann-La Roche Ltd., and Menarini, Speakers bureau: AstraZeneca, Boehringer Ingelheim, Chiesi, F. Hoffmann-La Roche Ltd., and Menarini
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Fredi, M., I. Cavazzana, A. Ceribelli, M. G. Lazzaroni, S. Barsotti, M. Benucci, L. Cavagna, et al. "FRI0239 ANTI-NXP2 ANTIBODIES: CLINICAL AND SEROLOGICAL ASSOCIATIONS IN A MULTICENTRIC ITALIAN STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 703.1–704. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1384.
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Background:anti-NXP2 antibodies is considered a serological marker of dermatomyositis (DM), with calcinosis, severe myositis and, in some series, cancer. Historically, these associations have been detected with immunoprecipitation (IP), but in the last few years commercial lineblot (LB) assay have been released.Objectives:to analyze the clinical features associated to anti-NXP2 antibodies, including the onset of concomitant cancers, both with LB and homemade IPMethods:clinical and serological data from medical charts of 213 patients with a diagnosis of inflammatory miosidites without anti-NXP2 (NXP2-), followed-up by two third-level Centers, and 61 anti-NXP2+ patients from 10 Rheumatological centers were analyzed. Anti-myositis specific (MSA) and anti-myositis associated antibodies (MAA) were detected in single centers by LB (Euroimmun Autoimmune Inflammatory Myopathies 16 antigens). Anti-NXP2 was confirmed by protein and RNA IP, as previously described (1)Results:clinical diagnosis of anti-NXP2+ positive with LB were 42 DM, 11 PM, inclusion body myositis (IBM) 4, necrotizing myositis and overlap (OM) 1 each. Anti-NXP2+ showed a lower age at onset (p<0.0001) more frequent diagnosis of DM (68.8%vs30%,OR5.2) and IBM (6.5%vs0.49%,OR14.8), typical skin manifestations, myositis (93%vs79% OR3.3), concomitant presence of another MSA (12.7%vs2%, OR6.41) and lower rate of features associated with OM or anti-synthetase syndrome. Serum from 49 NXP2+ was available and IP analysis was made with the confirmation of NXP2 in 31 sera (63.2%) with the following diagnosis: DM 27 cases, PM 3, IBM 1. Whilst the majority of the associations were confirmed comparing NXP2LB+/IP+ with the IIM NXP2-, some peculiar associations were found significant only for the double positive patients: dysphagia (53%vs 30%,OR 2.56) and calcinosis (22%vs6.5% OR4) whereas IBM diagnosis and the presence of concomitant MSA antibodies were lost. Survival time from cancer onset is shown in figure.IP did not confirmed anti-NXP2 antibodies in 18 sera: in 4 cases at least one MSA/MAA was identified by IP; these 18 patients did not show differences when compared with 213 anti-NXP2-.Conclusion:Protein IP confirmed anti-NXP2 antibodies in 63% of LB+ sera. Double positive cases showed more typical DM features and rarely occurred in IIM not DM. Anti-NXP2 positivity by LB should be confirmed by other methods in order to correctly diagnose and characterize IIM patients.References:[1]Arthritis Res Ther 2012,30;14:R97Acknowledgments:Forum Italiano per la Ricerca Malattie Autoimmuni (FIRMA)Disclosure of Interests:Micaela Fredi: None declared, Ilaria Cavazzana: None declared, Angela Ceribelli: None declared, Maria Grazia Lazzaroni: None declared, Simone Barsotti: None declared, Maurizio Benucci: None declared, Lorenzo Cavagna: None declared, Ludovico De Stefano: None declared, Andrea Doria Consultant of: GSK, Pfizer, Abbvie, Novartis, Ely Lilly, Speakers bureau: UCB pharma, GSK, Pfizer, Janssen, Abbvie, Novartis, Ely Lilly, BMS, Giacomo Emmi: None declared, Marco Fornaro: None declared, Federica Furini: None declared, Roberto Gerli: None declared, Maria Grazia Giudizi: None declared, Marcello Govoni: None declared, Anna Ghirardello: None declared, Luca Iaccarino Speakers bureau: GSK, Pfizer, Janssen, Novartis, Florenzo Iannone Consultant of: Speaker and consulting fees from AbbVie, Eli Lilly, Novartis, Pfizer, Roche, Sanofi, UCB, MSD, Speakers bureau: Speaker and consulting fees from AbbVie, Eli Lilly, Novartis, Pfizer, Roche, Sanofi, UCB, MSD, Maria Infantino: None declared, Alessandro Mathieu: None declared, Emiliano Marasco: None declared, Paola Migliorini: None declared, Boaz Palterer: None declared, paola parronchi: None declared, Matteo Piga: None declared, Federico Pratesi: None declared, Antonella Radice: None declared, Carlo Selmi: None declared, Valeria Riccieri: None declared, Marilin Tampoia: None declared, Giovanni Zanframundo: None declared, Angela Tincani: None declared, Franco Franceschini: None declared
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Campochiaro, C., E. Galli, E. Cocchiara, A. Tomelleri, S. Sartorelli, F. Muratore, M. G. Catanoso, et al. "THU0298 SWITCH OR SWAP STRATEGY IN TAKAYASU ARTERITIS PATIENTS FAILING TNFA INHIBITORS?" Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 377. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4693.
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Background:biologic drugs (bDMARD), especially anti-TNFα (TNFi), are used in refractory TA patients. Up to 60% of patients are eventually switched to a different bDMARD because of inefficacy. No data are available on which strategy (switch or swap) is more efficient in this setting.Objectives:to evaluate whether switch or swap strategy can be more effective in TA patients failing TNFis.Methods:TA patients treated with bDMARDs after TNFi failure were identified from 3 referral centres. Patients were classified as “switch” if treated with a different TNFi (infliximab, IFX, etanercept, ETN, golimumab, GOL, adalimumab, ADA) or “swap” if treated with a non-TNFi bDMARD (tocilizumab, TCZ, ustekinumab, USK). Baseline features and disease outcome (number of patients with NIH score <2, steroid dose reduction (SDR), disease relapses and vascular interventions) at month 6 and month 12 after 2ndbDMARD introduction were analyzed. Non parametric tests were used.Results:24 TA patients were identified. TNFi (IFX= 13; ADA= 8; ETN= 1; GOL= 2) was withheld after a median of 19 (8.5; 38) months (in 9 patients <12 months) for inefficacy in 19 (79%) patients and side effects in 5 (21%) patients. 11 (46%) patients were switched and 13 (54%) patients were swapped (12 to TCZ, 1 to USK). Baseline features at 2ndbDMARD start are summarized in Table 1. 2ndbDMARD retention at month 6 was comparable between switch (8, 73%) and swap (10, 77%) patients, p=1. Reasons for discontinuation were: inefficacy in 5 patients, allergic reaction in 1 switch patient. 5 (45%) switch and 6 (46%) swap patients had a NIH<2 (p=1). Median SDR was similar: 3.75(0-19.69) in swap and 4.37(1.87-10) mg daily in switch, p=0.829. Also at month 12, 2ndbDMARD retention was comparable: 7 (64%) switch vs 7 (54%) swap, p=0.210. Discontinuation reason was inefficacy in all cases. 6 (54%) switch and 4 (30%) swap patients had a NIH<2 (p=0.222). Median SDR from baseline was 3.75(0.62-7.5) in switch and 1.25 (0-6.25) in swap,p=0.620. 12 patients experienced a relapse within the first year: 10 (77%) swap and 2 (18%) switch patients, p=0.074. 3 patients underwent vascular interventions within the first year: 2 (18%) switch and 1 (8%) swap patient, p=0.576.Table 1.Disease features of switch and swap TA patients at 2nd bDMARD start.Switch (11 patients)Swap (13 patients)p valueAge (years)39 (31-54)37 (32-46)0.613Sex (female,%)821000.199Numano -I21 -IIa22 -IIb11 -III11 -IV02 -V56Disease duration (years)4 (2 -6)3 (2 – 8)0.743Previous csDMARD (%)911000.458TNFi duration (months)25 (9 – 27)16 (9 – 44)0.813Steroid dose (mg daily)15 (8.75 – 22.5)15 (10 – 25)0.726Current csDMARD, n(%)10 (91)9 (70)0.327 - Methotrexate66 - Azathioprine12 - Sirolimus10 - Salazopyrin01 - Cyclophosphamide10 - Mycofenolate10NIH ≥2 (%)73610.679CRP (mg/L)34 (14 – 73)24 (10 – 45)0.604ESR (mm/1h)43 (35 – 56)51 (35 – 68)0.729Conclusion:our retrospective study suggests that in first-line TNFi failure TA patients both switch and swap strategies are seemingly effective.Disclosure of Interests:Corrado Campochiaro Speakers bureau: Novartis, Pfizer, Roche, GSK, SOBI, Elena Galli: None declared, Emanuele Cocchiara: None declared, Alessandro Tomelleri: None declared, Silvia Sartorelli: None declared, Francesco Muratore: None declared, Maria Grazia Catanoso: None declared, Elena Baldissera Speakers bureau: Novartis, Pfizer, Roche, Alpha Sigma, Sanofi, Angelo Ravelli: None declared, Carlo Salvarani: None declared, Lorenzo Dagna Grant/research support from: Abbvie, BMS, Celgene, Janssen, MSD, Mundipharma Pharmaceuticals, Novartis, Pfizer, Roche, SG, SOBI, Consultant of: Abbvie, Amgen, Biogen, BMS, Celltrion, Novartis, Pfizer, Roche, SG, and SOBI
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Gentner, Bernhard, Gaetano Finocchiaro, Francesca Farina, Marica Eoli, Alessia Capotondo, Elena Anghileri, Matteo Barcella, et al. "Abstract 5213: Genetically modified Tie-2 expressing monocytes target IFN-α2 to the glioblastoma tumor microenvironment (TME): Preliminary data from the TEM-GBM Phase 1/2a study." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5213. http://dx.doi.org/10.1158/1538-7445.am2022-5213.
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Abstract Increasing clinical use of immune checkpoint inhibitors testifies to the importance of modulating the immune TME to obtain meaningful anti-tumor immune responses. Acting only on T lymphocytes may, however, not be sufficient, e.g. in immunologically-cold tumors or due to de novo or acquired resistance. Moreover, immune-related AEs remain hurdles of T cell therapies. To overcome these limitations and to awaken the immune system in an agnostic way against the tumor, we have developed a genetically modified cell-based autologous hematopoietic stem cell platform (Temferon) delivering immunotherapeutic payloads into the TME through Tie-2 expressing monocytes (TEMs), a subset of tumor infiltrating macrophages. TEM-GBM is an ongoing open-label, Phase 1/2a dose-escalating study evaluating the safety & efficacy of Temferon in up to 21 newly diagnosed patients with glioblastoma & unmethylated MGMT promoter assigned to 7 different cohorts (3 pts each) differing by Temferon dose (0.5-4.0x106/kg) and conditioning regimen (BCNU+ or Busulfan+Thiotepa). By Oct 15th, 2021, 15 pts (cohort 1-5) had received escalating doses of Temferon with a median follow up of 267 days (range: 60-749). Rapid engraftment and hematological recovery from nonmyeloablative conditioning occurred in all pts. Temferon-derived differentiated cells, as determined by the presence of vector genomes in the DNA, were found at increasing proportions in PB and BM, reaching up to 30% at 1 month for the highest cohorts tested (2.0x106/kg) and persisting up to 18 months, albeit at lower levels. Despite the significant proportion of engineered cells, only very low median concentrations of IFNα were detected in the plasma (D+30, 5.9; D+90, 8.8pg/mL) and in the cerebrospinal fluid (D+30, 1.5; D+90, 2.4pg/mL), indicating tight regulation of vector expression. SAEs were mostly attributed to conditioning chemotherapy (e.g. infections) or disease progression (e.g. seizures). 1 SUSAR (persistent GGT elevation) has occurred. Median OS is 14 mth from surgery (11 mth post Temferon). Four pts from the low dose cohorts underwent 2nd surgery. These recurrent tumors contained gene-marked cells and expressed IFN-responsive genes, indicative of local IFNα release by TEMs. In 1 pt, a stable lesion (as defined by MRI) had a higher proportion of T cells & TEMs, an increased IFN-response signature and myeloid re-programming revealed by scRNAseq, as compared to a synchronous, progressing tumor. TCR sequencing of blood and tumor samples showed a post-treatment increase in the cumulative frequency of tumor-associated T cell clones identified in 1st and 2nd surgery specimens (up to 4 out of 9 subjects). These results provide initial evidence for on-target activity of Temferon in GBM, to be consolidated with longer follow up in the higher dose cohorts. Citation Format: Bernhard Gentner, Gaetano Finocchiaro, Francesca Farina, Marica Eoli, Alessia Capotondo, Elena Anghileri, Matteo Barcella, Maria Grazia Bruzzone, Matteo Giovanni Carrabba, Valeria Cuccarini, Giorgio D'Alessandris, Francesco Di Meco, Valeria Ferla, Paolo Ferroli, Filippo Gagliardi, Federico Legnani, Pietro Mortini, Matteo Maria Naldini, Alessandro Olivi, Roberto Pallini, Monica Patanè, Rosina Paterra, Bianca Pollo, Marco Saini, Silvia Snider, Valentina Brambilla, Stefania Mazzoleni, Andrew Zambanini, Carlo Russo, Luigi Naldini, Fabio Ciceri. Genetically modified Tie-2 expressing monocytes target IFN-α2 to the glioblastoma tumor microenvironment (TME): Preliminary data from the TEM-GBM Phase 1/2a study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5213.
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Kampakoglou, Alexandros. "THEOCRITUS’ AEOLIC POEMS - (V.) Palmieri (ed., trans.) Teocrito: I carmi eolici (Idd. 28–31). Introduzione, edizione critica, traduzione e commento. (Hellenica 78.) Pp. vi + 189. Alessandria: Edizioni dell'Orso, 2019. Paper, €28. ISBN: 978-88-6274-908-4." Classical Review 72, no. 1 (December 27, 2021): 95–96. http://dx.doi.org/10.1017/s0009840x21003504.
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BARSANTI, GIULIO. "CARLO LUCIANO BONAPARTE, Iconografia della Fauna Italica per le quattro classi dei Vertebrati (a cura di Alessandro Minelli e Augusto Vigna Taglianti). Treviso: Canova, 2003. 3 vols., 460 + 1116 pp., ill., ISBN 88-8409-068-7." Nuncius 20, no. 2 (January 1, 2005): 501–2. http://dx.doi.org/10.1163/221058705x00497.
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Cipriano, E., F. Ceccarelli, F. R. Spinelli, C. Garufi, I. Duca, S. Mancuso, C. Alessandri, et al. "SAT0555 MUSCULOSKELETAL ULTRASOUND IN MONITORING RESPONSE TO JAKi IN RHEUMATOID ARTHRITIS PATIENTS: RESULTS FROM A LONGITUDINAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1235–36. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5987.
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Background:Therapeutic approach of rheumatoid arthritis (RA) patients has been enriched by the introduction of small molecules. In particular Jak inhibitors (JAKi), baricitinib and tofacitinib, demonstrated their efficacy in patients naïve or resistant to biological treatments in randomized controlled trials. Moreover, these drugs seem to be able to prevent radiographic progression. To date few data are available from the real life context. Ultrasonographic (US) assessment has became a valid imaging tool in the management of RA patients in clinical practice, allowing the evaluation of joint inflammatory status. Together with clinimetric assessment, US could provide a comprehensive assessment of drug response.Objectives:In the present study we aimed at assessing the early response to JAKi treatment by using musculoskeletal US.Methods:In this prospective longitudinal study, we collected data about all consecutive active RA patients starting treatment with JAKi. RA was diagnosed according to the 2010 ACR/EULAR criteria. At each visit, clinical and laboratory data were collected in a standardized and computerized form, including demographics, past medical history, co-morbidities, previous and concomitant treatments. According with study protocol, all patients underwent clinical and US assessment at the following time-points: baseline (T0), 4 weeks (T1) and 12 weeks (T2). Clinical evaluation included tender and swollen joint counts (0-28), patients global health assessment. C-reactive protein (CRP) levels were registered and disease activity was calculated by disease activity score (DAS) in 28 joints by using CRP (DAS28-CRP). A systematic multiplanar grey-scale and power Doppler (pD) US examination was performed by using MyLab Eight Exp Machine (Esaote, Florence, Italy) at level of 22 joints (bilateral I-V metacarpophalangeal, I-V proximal interphalangeal, wrist). According with OMERACT definitions (1) we assessed the presence of synovial effusion, hypertrophy and pD, that were scored according to a semi-quantitative scale (0-3). A total US inflammatory score (0-198) was obtained by their sum.Results:We enrolled 91 patients [F/M 77/14; median age 60.0 years (IQR 15.5); median disease duration 144 months (IQR 126)]. Of these patients, 54 (59.3%) were treated by baricitinib and the remaining 37 by tofacitinib. At baseline we found a median US inflammatory score of 20 (IQR 18.7) and a median DAS28-CRP of 5.0 (IQR 1.56). US assessment demonstrated significant reduction in the median values of inflammatory score already at T1 [median 13 (IQR 14.7), p<0.0001], that was maintained at T2 [median 10 (IQR 11), p<0.0001]. These results are represented in figure 1. Similar to US inflammatory score, a significant reduction was registered for DAS28-CRP median values [T1 3.5 (IQR 1.73), p<0.0001; T2 3.3 (IQR 1.8), p<0.0001]. No significant differences were found when subgrouping patients according with different JAKi drug, in terms US and clinimetric assessment.Conclusion:In the present study, specifically designed to evaluate the US-detected efficacy of JAKi in RA patients, we demonstrated in a real life setting a significant, early and sustained improvement of inflammatory joint status.References:[1]Wakefield et al, J Rheumatol 2005Disclosure of Interests:enrica cipriano: None declared, Fulvia Ceccarelli: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, Cristina Garufi: None declared, Ilaria Duca: None declared, Silvia Mancuso: None declared, cristiano alessandri Grant/research support from: Pfizer, Manuela Di Franco: None declared, Roberta Priori: None declared, Valeria Riccieri: None declared, Rossana Scrivo: None declared, Carlo Perricone: None declared, Guido Valesini: None declared, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Natalucci, F., F. Ceccarelli, E. Cipriano, G. Olivieri, C. Perricone, F. R. Spinelli, S. Truglia, et al. "THU0627-HPR JOINT INVOLVEMENT SIGNIFICANTLY INFLUENCES QUALITY OF LIFE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 557–58. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3791.
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Background:Joint involvement is one of the most common features observed in Systemic Lupus Erythematosus (SLE), potentially involving up to 90% of patients [1]. Several patients’ reported outcomes (PROs) have been employed to measure Quality of life (QoL) in SLE patients, but frequently not specifically developed for SLE patients. More recently, the LupusQoL has been validated, a disease specific questionnaire[2,3].Objectives:We focused at assessing the relationship between musculoskeletal manifestations and QoL in a large SLE cohort, by using the LupusQoL.Methods:SLE patients with a clinical history of joint involvement (arthralgia/arthritis – group A) were enrolled in the present study. SLE diagnosis was performed according to the revised 1997 ACR criteria. As a control group, we enrolled SLE patients without history of joint involvement (group B).Disease activity was assessed by the SLE Disease Activity Index-2000 (SLEDAI-2k). The activity of joint involvement was assessed by using the disease activity score on 28 joints (DAS28ESR). The LupusQoL was administered to the enrolled patients (Group A and Group B). It consists of 34 items referring to eight domains: physical health (PH), pain (P), planning (PL), intimate relationships (IR), burden to others (BO), emotional health (EH), body image (BI) and fatigue (F).Results:Group A included 110 patients [M/F 8/102; median age 49 years (IQR 13), median disease duration 156 months (IQR 216)], while group B included 58 patients [M/F 11/47; median age 40 years (IQR 15), median disease duration 84 months (IQR 108)]. Group A showed a significantly lower disease duration and mean age in comparison with group B (P< 0.001 for both comparisons). As represented in figure 1, group A showed significantly lower values in all LupusQoL domains except for “burden to others” domain. Moreover, we observed an inverse correlation between DAS28ESRand all the LupusQoL domains in group A patients [PH (r=-0.5, P>0.0001), P (r=-0.5, P<0.0001), PL (r=-0.5, P<0.0001), IR (r=-0.2, P=0.006), BO (r=-0.4, P=0.0004), EH (r=-0.3, P=0.0009), BI (r=-0.4, P=0.001), F (r=-0.4, P<0.0001)]. Conversely, SLEDAI-2k values inversely correlated only with PL (r=-0.3, P=0.006), IR (r=-0.25, P=0.02), EH (r=-0.3, P=0.02).Figure 1.Conclusion:In the present study, by using a disease specific PRO, we found a poorer QoL in SLE patients with joint involvement in comparison with those without this manifestation. Moreover,DAS28ESRsignificantly correlated with all LupusQol domains, differently from SLEDAI-2k, suggesting the need to evaluate joint involvement with a specific activity index.References:[1]Cervera R et al. Medicine 1993[2]McElhone K. et al. Arthritis Rheum 2007.[3]Conti F et al. Lupus 2014Group (A)Group (B)pPH80,38 ± 21,4362,88 ± 23.28< 0.0001P82,36 ± 25.0862,30± 26.02< 0.0001PL83,04 ± 27.8270,58± 29.450.001IR84,49± 25.9965,36± 36.330.0005BO69,58 ± 28.4663,45± 28.950.129EH71,98 ± 24.6964,69± 23.050.0169F73,69 ± 24.2959,78±26.060.0004B78,14 ± 24.6156,28±30.14<0.0001Disclosure of Interests:Francesco Natalucci: None declared, Fulvia Ceccarelli: None declared, enrica cipriano: None declared, Giulio Olivieri: None declared, Carlo Perricone: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, Simona Truglia: None declared, Francesca Miranda: None declared, cristiano alessandri Grant/research support from: Pfizer, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi, Guido Valesini: None declared
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Pirone, C., F. Ceccarelli, A. Selntigia, C. Perricone, S. Truglia, V. A. Pacucci, F. R. Spinelli, et al. "SAT0228 PREGNANCY OUTCOME IN SYSTEMIC LUPUS ERYTHEMATOSUS: A MONOCENTRIC COHORT ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1056.1–1057. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3106.
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Background:Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, affecting prevalently women in childbearing age. Thanks to pre-gestational counseling and multi-disciplinary approach, adopted in daily clinical practice, SLE patients are experiencing even more uncomplicated pregnancies.Objectives:Here, we evaluated pregnancy outcome in a large SLE cohort, compared to a control group including pregnant women without autoimmune diseases.Methods:Pregnant SLE patients (diagnosis made according to ACR 1997 criteria) were included in the present study, conducted in the context of a joint rheumatology/gynecology multi-disciplinary team. For each patient we collected demographic information, medical history, treatments, disease activity (SLEDAI-2K) chronic damage (SLICCdamage index), clinical and laboratory data, including serum complement level and autoantibodies. Pregnancy outcomes were reported longitudinally as well as disease relapses occurring during pregnancy and puerperium. Flares were defined as new onset or worsening disease-related manifestation in any organ/system.Results:Since 2008, 70 consecutive pregnancies occurred in 50 SLE patients [(median age at diagnosis 25 years (IQR 12.2), median age at first pregnancy 33 years (IQR 7), median disease duration 72 months (IQR 120)]. As controls, we evaluated 100 consecutive pregnancies in 100 women without autoimmune diseases [(median age 31 years (IQR 9)]. Table 1 reports the obstetric, fetal and neonatal outcomes of SLE patients compared to control group. A positive outcome in terms of live born infants was experienced in 88.6% of SLE pregnancies and in 88% of control group (p=NS). There were no statistically significant differences in any of the pregnancy outcomes evaluated; however, the percentage of small for gestational ages (SGA) was significantly higher in SLE group (22.8%versus11.0% P=0.003). A statistical association was found between SGA and positivity for anti-dsDNA, anti-SSA ed anti-SSB (p=0.0001, p=0.01, p=0.04 respectively). Miscarriage was significantly associated with disease-related serologic abnormalities [anti-dsDNA (p=0.0001), low C3 (p=0.0001) and low C4 (p=0.006)] and past smokinghabitus(p=0.0001); preterm birth was associated with anti-dsDNA, anti-CL and anti-B2GPI (p=0.001, p=0.0005, p=0.01 respectively). A disease flare was reported in 28 pregnancies (40%) and in 31 puerperium (44.3%). Figure 1 reports SLE relapses divided according to organ involvement. Flare during pregnancy was associated with positivity for anti-SSA (p=0.001), anti-SSB (p=0.01) and a-CL (p=0.006), whilepuerperiumrelapses were associated with previous renal involvement (p=0.0005), flare during pregnancy (p=0.01) and chronic damage (p=0.0001).Table 1.Pregnancy outcomes in 50 SLE and 100 controls.LES(Pregnancies N=70)Controls(Pregnancies N=100)POBSTETRIC OUTCOMEPreterm birth N/%18/25.719/19NSGestational hypertension N/%5/7.13/3NSGestational diabetes N/%5/7.15/5NSPre-eclampsia N/%2/2.91/1NSFETAL OUTCOMEMiscarriages N/%8/11.412/12NSPR interval elongation N/%4/6.4––IUGR N/%3/51/1NSNEONATAL OUTCOMESGA< 10° centile N/%16/22.811/110.003Weight at birth median-I.Q.R.2850-6883250-8140.003Apgar 1’ median-I.Q.R.8-18-1NSApgar 5’ median-I.Q.R.9-110-1NSFigure 1.Disease flares during and after 70 SLE pregnancies divided according to organ involvement.Conclusion:The present study confirms the role of pre-gestational counseling and a multi-disciplinary approach in the outcome of SLE pregnancies. Moreover, the high prevalence of disease relapse even more justifies the need for a combined rheumatology/gynecology multi-disciplinary approach.Disclosure of Interests:Carmelo Pirone: None declared, Fulvia Ceccarelli: None declared, Aikaterini Selntigia: None declared, Carlo Perricone: None declared, Simona Truglia: None declared, viviana antonella pacucci: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Speakers bureau: Lilly, BMS, Celgene, cristiano alessandri Grant/research support from: Pfizer, Guido Valesini: None declared, Giuseppina Perrone: None declared, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Citriniti, G., A. Soriano, E. Bertolini, G. Sandri, A. Bertani, I. Tinazzi, F. Martinis, et al. "POS0265 CLINICAL AND ULTRASONOGRAPHIC ENTHESITIS IN INFLAMMATORY BOWEL DISEASE WITH AND WITHOUT PSORIASIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 355.2–356. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4162.
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Background:Previous studies have reported an association between psoriasis (PsO) and inflammatory bowel disease (IBD). Coexistence of IBD and PsO has been associated with significant higher prevalence of enthesitis and dactylitis1.Objectives:To compare the prevalence of clinical and ultrasonographic peripheral enthesis abnormalities in a consecutive series of patients with IBD and psoriasis (PsO) as compared to a group of IBD patients without psoriasis (IBD).Methods:One-hundred seventy-four IBD consecutive patients [36 PsO and 138 IBD, M/F 91/83, mean age 42.6±14.7 years, mean disease duration 110 ±12.3 months] entered the study. A complete clinical examination, including rheumatological history, 66/68 peripheral joint count, MASES and LEI scores, BASDAI, and dactylitis count, was performed at study entry. Laboratory test (ESR, CRP, Hb, fecal calprotectin) were collected. Axial or peripheral SpA diagnosis was made using ASAS criteria 2.US examination was executed by a rheumatologist blind to clinical data, using an Esaote MyLabClass, 18-6MHz linear multifrequence transducer both in B-mode and PD-mode. The following sites were examined bilaterally: lateral epicondyle of the humerus, distal quadriceps femoris insertion into the patella, inferior pole of the patella, tibial distal insertion of the patellar tendon, calcaneal insertion of the Achilles tendon, and plantar aponeurosis insertion. Knee and ankle joints were evaluated for synovial hypertrophy, PD signal and fluid effusion. Enthesitis was defined according to OMERACT 3 and scored as 0-36 for GUESS and 0-136 for MASEI.Results:PsO patients had later IBD onset (mean age 39±14.7 vs 33 ± 13.2 in IBD group, p=0.02). There weren’t observed any significant differences in IBD duration and Crohn/UC prevalence.No significant difference between the two groups in rheumatological history and clinical examination was detected, except for familiar history of psoriasis (PsO 44% vs IBD 16%, p <0.001). Prevalence of SpA was 33,3% in PsO group and 37% in IBD group (p = 0.687).146 patients (83.4%) showed structural damage at ≥ 1 enthesis, 44 patients (25%) had at least 1 active enthesitis, with no significant difference between the two groups. PsO group showcased a significantly increased prevalence of patients having ≥ 1 thickened enthesis (86.1% vs 63.9%, p=0.009) and of PD signal at knee examination (11.1% vs 2.2%, p= 0.034). Higher values of GUESS score were observed in PsO (8.1±5.1 vs 5.8±3.9, p=0.017). Enthesis hypoechogenicity was more prevalent in IBD group (27.5% vs 11.1%, p=0.049).Enthesis thickness was significantly increased in PsO, in every examined site. Enthesophyte length was significantly increased in PsO group at quadriceps tendon, patellar distal insertion and Achilles tendon.Conclusion:No differences in clinical manifestation and rheumatological history between IBD and PsO patients were observed. Subclinical (US) abnormalities were significantly increased in IBD patients with associated PsO, as compared to patients affected by IBD.References:[1]Cantini, F. et al. J. Rheumatol.44, 1341–1346 (2017).[2]Rudwaleit, M. et al. Ann. Rheum. Dis.68, 777–783 (2009).[3]Balint, P. V. et al. Ann. Rheum. Dis.77, 1730–1735 (2018).Acknowledgements:Abbvie provided funding for medical writingDisclosure of Interests:Giorgia Citriniti: None declared, Alessandra Soriano: None declared, Elena Bertolini: None declared, Gilda Sandri: None declared, Angela Bertani: None declared, Ilaria Tinazzi: None declared, Federica Martinis: None declared, Nicolò Girolimetto: None declared, Carlo Salvarani: None declared, Marina Beltrami Grant/research support from: Abbvie provided funding for medical writing, Pierluigi Macchioni: None declared
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Mauro, D., A. Ciancio, C. DI Vico, L. Passariello, G. Rozza, M. D. Pasquale, I. Pantano, et al. "POS1211 SEROLOGICAL RESPONSE TO BNT162b2 mRNA ANTI-SARS-CoV-2 VACCINATION IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES: RESULTS FROM THE RHEUVAX COHORT." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 934.1–934. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1315.
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BackgroundTo date, globally considered, the literature suggests that AIRD may be at higher risk of infection and death due to COVID19 compared to the general population. Vaccination against SARS-CoV-2 reduces the risk of hospitalization and mortality. However, immunological alteration associated with Autoimmune Inflammatory Rheumatic Diseases (AIRD) and immunosuppressive medications may impair the response to vaccination. Emerging data suggest that immunosuppressive treatment may negatively impact the response to anti-SARS-CoV-2 vaccines in the AIRD population; data are robust for some treatments, more controversial for others.Identifying patients at higher risk of lack of protection is essential for shielding them and for adapting therapeutic protocol and vaccination timing.ObjectivesIn the light of the current COVID19 epidemic and the availability of effective vaccines, this study aims to identify predictors of non-response to anti-SARS-CoV-2 vaccines in patients affected by AIRD.MethodsAn observational cross-sectional study was conducted evaluating the serological response and the persistence of antibodies at eight weeks in IRD patient cohort and non-IRD control.IRD and age and sex-matched controls volunteer among the health professionals (CTRL) who underwent vaccination with two doses of BNT162b2 were recruited for this study. Anti-Trimeric Spike protein antibodies were assayed eight ± one week after the second vaccine dose. Univariate and logistic regression analyses were performed to identify predictors of non-response and low antibody titers.ResultsSamples were obtained from 237 IRD patients (m/f 73/164, mean age 57, CI 95% [56-59]): 4 autoinflammatory diseases (AI), 62 connective tissue diseases (CTD), 86 rheumatoid arthritis (RA), 71 spondylarthritis (SpA) and 14 vasculitis (Vsc). 232 CTRL were recruited (m/f 71/161, mean age 57, CI 95% [56-58]).Globally, IRD had a lower seroconversion rate (88.6% vs 99.6%, CI 95% OR [1.61-5.73], p<0.0001) and lower antibody titer compared to controls (median (IQR) 403 (131.5-1012) vs 1160 (702.5-1675), p<0.0001). After logistic regression, age, corticosteroid (CCS), Abatacept (ABA), and Mycophenolate Mofetil (MMF) use were predictors of non-response.The antibody titers eight weeks after the second dose of vaccine were lower in AIRD compared to controls, median (IQR) 403 (131.5-1012) vs 1160 (702.5-1675), p<0.0001 with no difference between sexes and age groups. CTD, RA and SpA had lower antibodies levels. However, the logistic regression model identified treatment with MMF, ABA, CCS, Methotrexate (MTX), Rituximab (RTX), Janus Kinase inhibitors (JAKi) and TNF inhibitors (TNFi) as independent predictors of serum titer. ABA, RTX, MMF, and MTX had the strongest effect size.ConclusionThe response to anti-SARS-CoV-2 vaccines is often impaired in AIRD patients under treatment and may pose them at higher risk of severe COVID-19. Although this work focused on serological response, most of the treatment the impaired vaccine response are known to act on T cells, possibly also influencing the cellular response. Evidence-based protocols are required to time vaccination and treatment to improve immunization of AIRD patients.References[1]Kroon, F. P. B. et al. Risk and prognosis of SARS-CoV-2 infection and vaccination against SARS-CoV-2 in rheumatic and musculoskeletal diseases: a systematic literature review to inform EULAR recommendations. Ann. Rheum. Dis. (2021).AcknowledgementsThe authors would like to thank Dr Daniela Iacono, Dr Carlo Iandoli, Dr Alessandra Milone, Dr Anna Pellegrlino, Dr Elisabetta Seguino and Mrs Maria Puca, for their contribution in data and blood samples collection, Dr Giorgia Della Polla for the valuable suggestions on data analysis. The authors are grateful also to all patients and the volunteers for their contribution.Disclosure of InterestsNone declared
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Lippi, Lorenzo, Alessandro de Sire, Antonio Ammendolia, Carlo Cisari, Konstantinos Venetis, Elham Sajjadi, Nicola Fusco, and Marco Invernizzi. "Abstract P4-10-15: Whole-body vibration combined with physical exercise to treat aromatase inhibitor-induced musculoskeletal symptoms in breast cancer women: Results of a pilot randomized controlled study." Cancer Research 82, no. 4_Supplement (February 15, 2022): P4–10–15—P4–10–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-10-15.
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Abstract BACKGROUND. Aromatase inhibitors (AIs) represent a cornerstone of hormone receptor (HR)-positive breast cancers management. However, AIs-induced musculoskeletal symptoms (AIMSS) might be frequently reported during estrogen depletion, with a crucial impact on cancer treatment adherence [1-2]. To date, physical exercise has been proposed as a promising therapeutic intervention to improve symptoms in AIMSS breast cancer patients [3] and recently, also whole-body vibration (WBV) showed promising results in these women. WBV is an effective neuromuscular training proposed to enhance muscle function and proprioception through various frequencies of mechanical vibration inducing repetitive muscle contractions. However, at present, data about tailored and effective multimodal rehabilitative exercise protocols to treat AIMSS are still controversial [3]. Therefore, this pilot randomized controlled study aimed at assessing the safety and efficacy of WBV in breast cancer women suffering from AIMSS. METHODS: In this study we recruited adults women undergoing AIs treatment for breast cancer and suffering from AIMSS. Twentytwo patients were enrolled and subsequently randomly assigned 1:1 to two groups. Group A received physical exercise and WBV, while Group B received physical exercise combined with sham WBV. The patients were assessed at the baseline (T0) and after 4 weeks of treatment (T1). The primary endpoint was the numerical pain rating scale (NPRS) for pain assessment; the secondary endpoints were the handgrip strength (HGS) test to assess appendicular muscle strength, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to assess pain, joint stiffness, and function; 10-meter walking test (10MWT) and 6MWT to evaluate physical performance; the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) to assess function, symptoms, and global health. RESULTS: Group A (n=11; mean age: 51.73±10.73 years; body mass index (BMI): 25.56±5.17 kg/m2) showed a statistically significant improvement of pain (NPRS: 6.82±1.17 vs 5.73±1.01; p=0.031). In contrast, patients in Group B, control group, (n=11; mean age: 58.55±9.71 years; BMI: 27.31±3.84 kg/m2), did not significantly improved in terms of pain (NPRS: 6.91±2.02 vs 5.91±2.51; p=0.07). Moreover, significant differences between groups at T1 were found in terms of WOMAC physical functioning (Group A: 77.56±9.853; Group B: 65.63±14.27; p=0.044). Furthermore, a significant improvement in terms of muscle strength, physical performance and quality of life (EORTC QLQ-C30) were reported in intragroup analysis in both groups, without significant differences between groups. We did not register dropouts or side effects in both groups. Lastly, both patients and the physical therapist reported a high level of satisfaction about the rehabilitative intervention performed. CONCLUSION: These findings showed that physical exercise and WBV combination therapy might be safe, well-tolerated and effective in patients with AIMSS. However, further studies are warranted to assess long terms effects of this combined rehabilitative treatment. REFERENCES: 1. Molehin D, Rasha F, Rahman RL, Pruitt K. Regulation of aromatase in cancer. Mol Cell Biochem. 2021. 2. Murphy CC, Bartholomew LK, Carpentier MY, Bluethmann SM, Vernon SW. Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review. Breast Cancer Res Treat. 2012;134(2):459-78. 3. Roberts KE, Rickett K, Feng S, Vagenas D, Woodward NE. Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer. Cochrane Database Syst Rev. 2020;1:CD012988. Citation Format: Lorenzo Lippi, Alessandro de Sire, Antonio Ammendolia, Carlo Cisari, Konstantinos Venetis, Elham Sajjadi, Nicola Fusco, Marco Invernizzi. Whole-body vibration combined with physical exercise to treat aromatase inhibitor-induced musculoskeletal symptoms in breast cancer women: Results of a pilot randomized controlled study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-10-15.
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Orefice, V., F. Ceccarelli, C. Barbati, R. Lucchetti, G. Olivieri, E. Cipriano, F. Natalucci, et al. "THU0227 CAFFEINE INTAKE MODULATES DISEASE ACTIVITY AND CYTOKINES LEVELS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 340.2–341. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2100.
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Background:Systemic lupus erythematosus (SLE) is an autoimmune disease mainly affecting women of childbearing age. The interplay between genetic and environmental factors may contribute to disease pathogenesis1. At today, no robust data are available about the possible contribute of diet in SLE. Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor2.In vitrodose-dependent treatment with caffeine seems to down-regulate mRNA levels of key inflammation-related genes and similarly reduce levels of different pro-inflammatory cytokines3.Objectives:We evaluated the impact of caffeine consumption on SLE-related disease phenotype and activity, in terms of clinimetric assessment and cytokines levels.Methods:We performed a cross-sectional study, enrolling consecutive patients and reporting their clinical and laboratory data. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2k)4. Caffeine intake was evaluated by a 7-day food frequency questionnaire, including all the main sources of caffeine. As previously reported, patients were divided in four groups according to the daily caffeine intake: <29.1 mg/day (group 1), 29.2-153.7 mg/day (group 2), 153.8-376.5 mg/day (group 3) and >376.6 mg/day (group 4)5. At the end of questionnaire filling, blood samples were collected from each patient to assess cytokines levels. These were assessed by using a panel by Bio-Plex assays to measure the levels of IL-6, IL-10, IL-17, IL-27, IFN-γ, IFN-α and Blys.Results:We enrolled 89 SLE patients (F/M 87/2, median age 46 years, IQR 14; median disease duration 144 months, IQR 150). The median intake of caffeine was 195 mg/day (IQR 160.5). At the time of the enrollment, 8 patients (8.9%) referred a caffeine intake < 29.1 mg/day (group 1), 27 patients (30.3%) between 29.2 and 153.7 mg/day (group 2), 45 patients (51%) between 153.8 and 376.5 mg/day (group 3) and 9 patients (10.1%) >376.6 mg/day (group 4). A negative correlation between the levels of caffeine and disease activity, evaluated with SLEDAI-2K, was observed (p=0.01, r=-0.26). By comparing the four groups, a significant higher prevalence of lupus nephritis, neuropsychiatric involvement, haematological manifestations, hypocomplementemia and anti-dsDNA positivity was observed in patients with less intake of caffeine (figure 1 A-E). Furthermore, patients with less intake of caffeine showed a significant more frequent use of glucocorticoids [group 4: 22.2%,versusgroup 1 (50.0%, p=0.0001), group 2 (55.5%, p=0.0001), group 3 (40.0%, p=0.009)]. Moving on cytokines analysis, a negative correlation between daily caffeine consumption and serum level of IFNγ was found (p=0.03, r=-0.2) (figure 2A); furthermore, patients with more caffeine intake showed significant lower levels of IFNα (p=0.02, figure 2B), IL-17 (p=0.01, figure 2C) and IL-6 (p=0.003, figure 2D).Conclusion:This is the first report demonstrating the impact of caffeine on SLE disease activity status, as demonstrated by the inverse correlation between its intake and both SLEDAI-2k values and cytokines levels. Moreover, in our cohort, patients with less caffeine consumption seems to have a more severe disease phenotype, especially in terms of renal and neuropsychiatric involvement. Our results seem to suggest a possible immunoregulatory dose-dependent effect of caffeine, through the modulation of serum cytokine levels, as already suggested byin vitroanalysis.References:[1]Kaul et alNat. Rev. Dis. Prim.2016; 2. Aronsen et alEurop Joul of Pharm2014; 3. Iris et alClin Immun.2018; 4. Gladman et al J Rheumatol. 2002; 5. Mikuls et alArth Rheum2002Disclosure of Interests:Valeria Orefice: None declared, Fulvia Ceccarelli: None declared, cristiana barbati: None declared, Ramona Lucchetti: None declared, Giulio Olivieri: None declared, enrica cipriano: None declared, Francesco Natalucci: None declared, Carlo Perricone: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, cristiano alessandri Grant/research support from: Pfizer, Guido Valesini: None declared, Fabrizio Conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi
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Sebastian, A., A. Tomelleri, P. Macchioni, G. Klinowski, C. Salvarani, A. Kayani, M. Tariq, et al. "POS0818 SOUTHEND PRE-TEST PROBABILITY SCORE AND HALO SCORE AS MARKERS FOR DIAGNOSIS AND MONITORING OF GCA: EARLY RESULTS FROM THE PROSPECTIVE HAS-GCA STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 699–700. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4064.
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BackgroundUltrasound (US) is recommended as the first line imaging test in patients with suspected Giant Cell Arteritis (GCA). Traditionally, the US halo sign has been used for diagnosis. We have recently described a composite Halo Score that allows to quantify vascular inflammation on US. Prospective studies on response and disease monitoring are lacking.ObjectivesTo prospectively assess the role of US in diagnosing and monitoring GCA patients. We report early baseline and 12-month data on our current recruitment in a study that has suffered disruption from the pandemic.MethodsHAS GCA (IRAS#264294) is an ongoing, prospective, multicentre study recruiting from referrals of suspected GCA to fast-track clinics. Based on the Southend GCA clinical pre-test probability score (SPTPS)1, patients were stratified in to low, intermediate and high risk categories2. Temporal and axillary US Halo Scores were calculated from the halo thickness and extent in bilateral temporal arteries, parietal and frontal branches (TAHS) and axillary arteries (AAHS). These scores were summed (TAHS x1 plus; AAHS x3) to generate a Total Halo Score (THS)3.Mann Whitney U test was used to compare baseline features between GCA and controls. Wilcoxon signed rank test was used to evaluate disease features at baseline and at 12 months in GCA patients. Sensitivity (Sn), Specificity (Sp) and ROC curve were calculated, where applicable. P value <0.05 is statistically significantResults202 patients (71 GCA, 131 controls) have been recruited thus far: 23 completed 12-month follow up assessment; 6 were lost to follow up (4 died, 2 withdrew consent due to pandemic). Demographics, clinical features, and US results are shown (Table 1).Table 1.Baseline features of GCA patients and controlsGCA (n=71)Controls (n=131)P-valueAge, median (IQR)75 (70-81)68 (62-76)0.001Female, n (%)38 (54)89 (68)0.05SPTPS category, n (%) Low risk0 (0)59 (45)<0.001 Intermediate risk16 (23)49 (37)0.04 High risk55 (77)23 (18)<0.001Halo score (HS), median (range) Temporal artery HS12 (0-22)2 (0-17)<0.0001 Axillary artery HS12 (0-21)6 (0-18)<0.0001 Total HS21 (2-40)8 (0-29)<0.0001Clinical features, n (%) Temporal headache53 (75)93 (71)0.62 Scalp tenderness36 (51)40 (31)0.006 Jaw claudication38 (54)9 (7)<0.001 PMR symptoms29 (41)35 (27)0.06 Constitutional symptoms42 (59)29 (22)<0.001 Visual disturbance40 (56)58 (44)0.11 Vision loss21 (30)9 (7)<0.001AA, axillary artery; GCA, Giant cell arteritis; TA, Temporal arteryAmong GCA patients, 50 had cranial, 5 large-vessel and 16 mixed phenotypes. Diseases were diagnosed by US and additional tests such as PET CT.Jaw claudication (54%) and constitutional symptoms (59%) were the dominant features in GCA patients. Median age was 75 years in GCA (54% females) and 68 years in controls (68% females). GCA and controls were stratified by SPTPS to Low risk (0% vs 45%; Sn-undefined, Sp-98), Intermediate risk (23% vs 37%; Sn-81, Sp-98) and High risk (77% vs 18%; Sn-98, Sp-91). Optimal SPTPS cut-off point was ≥12 (Sn-89, Sp-76).Median THS was 21 in GCA and 8 in controls. Optimal cut-off Halo Score in diagnosis was TAHS ≥5 (Sn-89, Sp-86), AAHS ≥11 (Sn-55, Sp-75), THS ≥15 (Sn-79%, Sp-86%). Baseline Halo Score and CRP levels showed positive correlation (spearman rank correlation). Among the 23 patients who completed 12-months follow up, median TAHS, AAHS and THS reduced from 12 to 2, 12 to 6 and 21 to 10, respectively (Figure 1).ConclusionAlong with SPTPS, Halo Score successfully discriminates GCA from non GCA mimics and. HS is effective in showing 12-month response. This score may be a useful marker to monitor GCA disease activityReferences[1]Laskou F et al. Clin Exp Rheumatol. 2019[2]Sebastian A et al. RMD Open. 2020[3]Sebastian A et al. BMC Rheumatol. 2020Disclosure of InterestsAlwin Sebastian: None declared, Alessandro Tomelleri: None declared, Pierluigi Macchioni: None declared, Giulia Klinowski: None declared, Carlo Salvarani: None declared, Abdul Kayani: None declared, Mohammad Tariq: None declared, Diana Prieto-Peña: None declared, Edoardo Conticini: None declared, Muhammad Khurshid: None declared, Sue Inness: None declared, Jo Jackson: None declared, Kornelis van der Geest Speakers bureau: Roche, Grant/research support from: Mandema stipend, Bhaskar Dasgupta: None declared
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Regan, Meredith M., Barbara A. Walley, Gini F. Fleming, Prudence A. Francis, Marco A. Colleoni, István Láng, Henry L. Gómez, et al. "Abstract GS2-05: Randomized comparison of adjuvant aromatase inhibitor exemestane (E) plus ovarian function suppression (OFS) vs tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC): update of the combined TEXT and SOFT trials." Cancer Research 82, no. 4_Supplement (February 15, 2022): GS2–05—GS2–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs2-05.
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Abstract Background The updated combined SOFT+TEXT analysis, after 9 years median follow-up (MFU), revealed that adjuvant E+OFS vs T+OFS significantly improved disease-free survival (DFS) and distant recurrence-free interval (DRFI) but not overall survival (OS) in premenopausal women with HR+ early BC (Francis et al NEJM 2018). Given the high rate of OS in both arms and the long-term risk of relapse in HR+ BC, continued follow-up is key to assessing treatment benefit. We report a planned update analysis including OS with database lock of May 2021, after 13 years MFU.. Methods TEXT and SOFT enrolled premenopausal women with HR+ early BC from November 2003 to April 2011 (2660 in TEXT, 3047 in SOFT intention-to-treat (ITT) populations). TEXT randomized women within 12 weeks of surgery to 5 years E+OFS vs T+OFS; chemotherapy (CT) was optional and concurrent with OFS. SOFT randomized women to 5 years E+OFS vs T+OFS vs T alone, within 12 weeks of surgery if no CT planned, or within 8 months of completing (neo)adjuvant CT. Both trials were stratified by CT use. For the combined analysis of E+OFS vs T+OFS, the primary endpoint was DFS defined as invasive local, regional, distant recurrence, contralateral BC, second malignancy, death. Secondary endpoints included invasive breast cancer-free interval (BCFI), DRFI and OS.. Results: At database lock there were 953 DFS events and 473 deaths among 4690 pts assigned to T+OFS or E+OFS. In the ITT population, DFS, BCFI and DRFI outcomes for pts assigned E+OFS (n=2346) continued to be significantly improved over T+OFS (n=2344). 12-yr DFS was 80.5% vs. 75.9% (4.6% absolute improvement; HR 0.79 95% CI 0.70-0.90), 12-yr BCFI was improved by 4.1% and 12-yr DRFI by 1.8%. At 12 years OS was excellent in both groups, 90.1% in pts assigned E+OFS vs 89.1% in pts assigned T+OFS (HR 0.93; 95% CI, 0.78-1.11). There was heterogeneity of relative treatment effect according to HER2 status. When enrollment commenced, anti-HER2 adjuvant therapy was not standard; 53% of 583 pts with HER2+ tumors received HER2-targeted therapy. Below are Kaplan-Meier 12-yr estimates for patients with HER2 negative tumors by trial and chemotherapy stratum and for those with high-grade tumours, as an example of high-risk feature (Table). There is an emerging OS benefit for E+OFS vs T+OFS in pts with HER2 negative tumors who received chemotherapy in both trials.In pts with HER2-negative tumors, clinically-relevant outcome benefits were also seen in other high-risk subgroups: 12-yr DFS and OS were improved by 7.4% and 2.7%, respectively, in pts with pN1a disease, and by 10.6% and 4.5%, respectively, in those with tumors >2cm. Conclusions After 13 years MFU, adjuvant E+OFS, as compared with T+OFS, shows a sustained reduction in the risk of recurrence, more consistent in HER2 negative patients and in those with high-risk disease features, e.g., indication for adjuvant chemotherapy and G3 tumors. Oncologists may use this information to discuss potential benefits of E+OFS with individual patients. Follow-up continues for 5 additional years. Chemotherapy HER2-negativeSOFTT+OFS (n=424)E+OFS (n=411)Absolute difference12-yr DFS67.4%74.1%6.7%12-yr OS81.1%84.4%3.3%TEXTT+OFS (n=656)E+OFS (n=661)Absolute difference12-yr DFS71.0%78.4%7.4%12-yr OS83.5%86.8%3.3%No chemotherapy HER2-negativeSOFTT+OFS (n=445)E+OFS (n=447)Absolute difference12-yr DFS82.9%88.2%5.3%12-yr OS96.1%96.9%0.9%TEXTT+OFS (n=499)E+OFS (n=492)Absolute difference12-yr DFS80.2%86.7%6.5%12-yr OS95.9%96.2%0.2%G3 HER2-negativeT+OFS (n=423)E+OFS (n=405)Absolute difference12-yr DFS62.7%73.0%10.3%12-yr OS78.1%83.6%5.5% Citation Format: Meredith M Regan, Barbara A Walley, Gini F Fleming, Prudence A Francis, Marco A Colleoni, István Láng, Henry L Gómez, Carlo A Tondini, Harold J Burstein, Matthew P Goetz, Eva M Ciruelos, Vered Stearns, Hervé R Bonnefoi, Silvana Martino, Charles E Geyer, Jr, Claudio Chini, Alessandro M Minisini, Simon Spazzapan, Thomas Ruhstaller, Eric P Winer, Barbara Ruepp, Sherene Loi, Alan S Coates, Aron Goldhirsch, Richard D Gelber, Olivia Pagani. Randomized comparison of adjuvant aromatase inhibitor exemestane (E) plus ovarian function suppression (OFS) vs tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC): update of the combined TEXT and SOFT trials [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS2-05.
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Zabotti, A., M. Piga, A. Zanetti, M. Canzoni, N. Boffini, V. Picerno, G. Zanframundo, et al. "OP0223 DEVELOPMENT AND PRELIMINARY VALIDATION OF ULTRASONOGRAPHIC DISEASE ACTIVITY AND DAMAGE SCORES IN PSORIATIC ARTHRITIS PATIENTS: RESULTS FROM THE UPSTREAM (ULTRASOUND IN PSORIATIC ARTHRITIS TREATMENT) STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 134–35. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2609.
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Background:The UPSTREAM (NCT03330769) is a 24-month multi-center prospective cohort study that primarily aims to evaluate the additional value of musculoskeletal ultrasound (msk-US) over clinical examination in predicting 6-month minimal disease activity in Psoriatic Arthritis (PsA). (1)Objectives:To develop and preliminarily validate an activity msk-US score and a damage msk-US score for PsA using the UPSTREAM database.Methods:Patients classified with PsA according to CASPAR criteria and starting a new course of therapy for clinically active peripheral joint disease were eligible. The information regarding objectives, study design, clinical and US assessment has already been published (1). The msk-US examination was performed in 42 joints, 36 tendons, 12 entheses and 2 bursae defined through a web-based exercise (2). The sonographic elementary lesions were allocated to disease activity [i.e. synovitis (sy), tenosynovitis (ts), peritendinitis (pt), bursitis (bs) all evaluated both in Grey Scale (GS) and Power Doppler (PD) and active enthesitis (en)] and to damage (i.e. joint erosion, bone proliferation, tendon tear, enthesophyte, calcification and irregular enthesis bone profile). Hands and feet X-ray were assessed using the modified Sharp-Van der Heijde (mSVH) score. A principal component (PC) analysis (PCA) was performed for each score and the number of PCs was defined by means of parallel analysis using baseline data. Each PC was normalized (n) taking into account the proportion between the observed value (e.g. sy-GS count) and the maximum expected value (e.g. 42 for sy-GS). Spearman’ correlation was used to investigate the construct and discrimination validity of the new scores.Results:Between February 2017 and May 2020, 312 PsA patients (155 men), with a mean (SD) age of 52.8 13.4, were enrolled from 19 centers; 22 expert sonographers were involved with substantial agreement for US lesions evaluated (k ≥0.7). The median [IQR] disease duration was 1.3 [0.1-6.1] years and the median [IQR] tender joint and swollen joint counts were 6 [3-13] and 2 [1-5], respectively. The weight derived from PCA for each sonographic lesions and the final equation for calculating the scores are reported in Figure 1 (1A activity and 1B damage). The final msk-US activity score [n(ts-GS + ts-PD)*2.87] + [n(bs-GS + bs-PD)*1.76] + [n(pt-GS + pt-PD)*1.43] + [n(active en)*1.00] + [n(sy-GS)*0.83] + [n(sy-PD)*0.45] has the best construct and discrimination validities according to a significant correlation with all clinical variables usually related to clinical activity (Table 1). The msk-US damage score correlated with mSVH score, HAQ and other clinical variables (Table 1).Table 1.VariablesMsk-US activity scoreMsk-US damage scoreSpearman correlationP-valueSpearman correlationP-valueESR0.1960.0020.0750.235CRP0.209<0.0010.0680.254TJC0.338<0.0010.286<0.001SJC0.338<0.0010.0720.221Dactylitis count0.284<0.001-0.0610.306LEI0.1940.0010.214<0.001Physician GA0.150.0120.0160.793Patient GA activity0.1380.018-0.0730.221Patient GA pain0.1990.001-0.0270.648HAQ0.238<0.0010.1460.014BASDAI0.237<0.0010.1750.003PSAID-90.70.0040.1480.013DAPSA0.392<0.0010.228<0.001Sharp van Der Heijde score0.1150.20.2660.003Figure 1.Conclusion:These newly developed and preliminary validated msk-US activity and damage scores could be used in patients with PsA in the context of observational and controlled trials.References:[1]Canzoni M et al. BMJ Open. 2018;8:e021942.[2]Zabotti A et al. Ann Rheum Dis 2018;77:1537–1538.Acknowledgements:Alberto Batticciotto; Oscar Massimiliano Epis; Luisa Arcarese; Luca Navarini; Marta Caprioli; Mirco Magnani; Roberta Ramonda; Marco Amedeo CimminoDisclosure of Interests:Alen Zabotti: None declared, Matteo Piga: None declared, Anna Zanetti: None declared, Marco Canzoni: None declared, nicola boffini: None declared, valentina picerno: None declared, Giovanni Zanframundo: None declared, Ettore Silvagni: None declared, Ivan Giovannini: None declared, BERND RAFFEINER: None declared, Palma Scolieri: None declared, Paola Mancini: None declared, Simone Parisi: None declared, Alessandra Bortoluzzi Grant/research support from: GSK, Garifallia Sakellariou Consultant of: Consultant for Abbvie and Novartis, Orazio De Lucia: None declared, Ilaria Tinazzi: None declared, Fabiana Figus: None declared, Luca Idolazzi Speakers bureau: Received grants as speaker for Eli Lilly, UCB, Celgene, MSD, Abbvie, Novartis, Paid instructor for: Paid instructor for UCB during Product specialist Meeting, Mariagrazia Lorenzin: None declared, Sara Zandonella Callegher: None declared, Alberto Cauli: None declared, Greta Carrara: None declared, Carlo Alberto Scirè: None declared, Annamaria Iagnocco: None declared
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Silvagni, E., S. Missiroli, S. Patergnani, C. Boncompagni, M. S. Ciliento, G. Lanza, M. Perrone, et al. "POS0328 AUTOPHAGY MODULATION BY TOFACITINIB IMPROVES PSORIATIC ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES FUNCTION." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 415–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1427.
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BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory systemic disease, and peripheral joints involvement is responsible of significant morbidity for patients, leading to damage accrual. Different drugs are available for the systemic management of this condition, with different mechanisms of action. Nevertheless, the rules driving the correct therapeutical choice in each individual patient are not completely defined. Janus kinases (JAK) inhibitors are a class of drugs able to reduce synovial inflammation, and tofacitinib, a JAK1/3 inhibitor, is the most studied. Preliminary evidence suggest an effect of tofacitinib on fibroblast-like synoviocytes (FLS) from PsA patients, reducing pro-invasive and pro-inflammatory properties. The link between JAK inhibition and FLS function improvement at synovial level is not fully understood.ObjectivesTo evaluate the effect of tofacitinib on spontaneous autophagic activity of PsA FLS, and to confirm its effect on anti-inflammatory and anti-invasive properties of PsA FLS and synovial explants.MethodsThis is an in vitro study. Patients with active PsA underwent ultrasound-guided synovial biopsy. Histological evaluation was performed according to Krenn’s synovitis score. FLS, PBMCs and synovial explants cultures were set up, and cells were treated in vitro with tofacitinib 1 µM or vehicle control for 24h. Protein levels in cellular homogenates were analysed by western blot for relevant autophagy markers. Autophagy was also studied by fluorescence microscopy using GFP-LC3. Chemokines/cytokines levels into culture supernatants were quantified by ELISA. Migration assays were used to investigate the effect of tofacitinib on invasive properties of FLS. Differences were determined adopting the non-parametric Wilcoxon signed rank test.Results16 patients with moderately active PsA were enrolled (Table 1). Mean (SD) Krenn’s synovitis score was 4.4. (1.9). Tofacitinib significantly increased LC3-II and ATG7 levels in PsA FLS compared to vehicle control, while p62 levels were not significantly affected, suggesting an increase in spontaneous autophagy activity, confirmed by LC3-autophagic vesicles count (Figure 1). No effect was highlighted in PBMCs and synovial explants cultures. Tofacitinib significantly reduced migration properties of PsA FLS, as well as MCP-1 and IL-6 release into FLS and synovial explants cultures supernatants.Table 1.Baseline demographic and clinical data of included patients (N=16).VariablesFrequencyAge (years), mean (SD)59.8 (7.9)Female, N (%)5 (31.3%)Disease duration (years), mean (SD)9.7 (7.9)CRP (mg/dl), mean (SD)1.5 (2.0)Patient Global Activity (0-100), mean (SD)73.4 (16.9)Physician Global Activity (0-100), mean (SD)56.3 (18.1)DAPSA, mean (SD)25.6 (6.8)HAQ (0-3), mean (SD)0.9 (0.5)Previous csDMARDs treatment, N (%)13 (81.3%)Previous bDMARDs treatment, N (%)6 (37.5%)Grey scale synovitis - joint to be biopsied (0-3), mean (SD)1.9 (0.8)Joint effusion - joint to be biopsied (0-3), mean (SD)1.4 (0.7)Power Doppler - joint to be biopsied (0-3), mean (SD)0.5 (0.6)Krenn’s synovitis score (0-9), mean (SD)4.4 (1.9)Abbreviations: SD, standard deviation; CRP, C reactive protein; DAPSA, Disease Activity Index for Psoriatic Arthrititis; HAQ, Health Assessment Questionnaire; csDMARD, conventional synthetic disease modifying antirheumatic drugs; bDMARD, biological disease modifying antirheumatic drugs.Figure 1.Tofacitinib significantly increased LC3-II and ATG7 levels in PsA FLS homogenates (A), and LC3-autophagic vesicles (B). Tofacitinib significantly reduced MCP-1 and IL-6 release into FLS cultures supernatants (C), and reduced PsA FLS migration properties at 24h (D).ConclusionThe induction of autophagy by tofacitinib might permit a better functioning of PsA FLS, with a coherent reduction in pro-invasive and pro-inflammatory properties. This may contribute to the rationale for tofacitinib use in PsA management.References[1]Gao Ann Rheum Dis. 2016 Jan;75(1):311-5[2]O’Brien Front Immunol. 2021 Jun 24;12:672461.Disclosure of InterestsEttore Silvagni Grant/research support from: E. Silvagni has received research support from AbbVie., Sonia Missiroli: None declared, Simone Patergnani: None declared, Caterina Boncompagni: None declared, Maria Sofia Ciliento: None declared, Giovanni Lanza: None declared, Mariasole Perrone: None declared, Alessandra Bortoluzzi: None declared, Marcello Govoni: None declared, Carlotta Giorgi: None declared, Carlo Alberto Scirè Grant/research support from: C.A. Scirè has received research support from AbbVie., Paolo Pinton: None declared
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Arienzo, Francesca, Domenico Campagna, Paola Scavinia, Laura Broglia, Laura Broglia, Alessandra Ascarelli, Helena Colavito, et al. "Abstract P4-07-27: Clipped lymph nodes for cN+ patients decrease false negative rate and lead to potential changes in surgical and oncological management after clinical complete response following neoadjuvant chemotherapy." Cancer Research 83, no. 5_Supplement (March 1, 2023): P4–07–27—P4–07–27. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-07-27.
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Abstract Introduction Targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC) is a new axillary staging technique that consists of surgical removal of biopsy-proven, positive, clipped axillary nodes (CLN) in addition to the sentinel lymph node biopsy (SLNB), and provides for more conservative axillary surgery1. A question was recently raised whether clipping a positive node for later assessment indeed leads to a management change2. The purpose of our study is to report the feasibility of TAD and to evaluate false negative rate (FNR), impact on surgical ad oncological management. Materials and methods This retrospective, single-institution, study included 73 consecutive women operated between 2019 and 2021 after NAC for cN+ disease confirmed by citology or histology, whose diseased lymph-node was marked with a clip before therapy. At surgery, in case of clinical-radiological complete response, patients underwent TAD (dual mapping with radiocolloid and blue dye + CLN) (n=43), or TAD plus ALND if any residual disease (n=30). The chemoterapeutsic regimen were antracycline/taxane based, with trastuzumab in case of HER2+ tumors. Patients were routinely evaluated with a breast MRI both before and after NAC. Results Clinical and pathological details of the 73 enrolled patients are listed in Table 1. The mean age at diagnosis was 49.53±10 years. Pathologic complete response was achievied in 32 out 73 patients (43.8%) with the greatest rate in HR-/HER2+ tumors (n=10/12; 83.3%). The identification rate of the CLN was 91.8% (68/73), and it was one of SLNs in 68.5% (50/73) of the cases. In cases in which one, two or three or more SLNs were identified, the CLN was in the SLN specimen in 42.9%, 77.8% and 81.8% of cases, respectively. The FNR of the SLN was 18.5% (CI: 4.9-38.1). In 18 cases the CLN was not in the SLN specimen; eleven out of 18 CLNs were positive, leading to ALND, and three of them had additional positive LNs. Only in one case the CLN was negative and the SLN was positive. In 3 cases (4.1%), the CLN was positive in the absence of residual tumour in the breast leading a potential change in the oncological management. Conclusions Removal of CLN after NAC is feasible, allowing de-escalation of surgical management of cN+ women in case of clinical-radiological complete response, as 59% of women avoided a formal ALND. The CLN coincides with SLN in about 70% of cases (more than 80% if three or more SLNs are identified) and reflects the overall status of the axilla in 97.3% of the cases. Adding CLN to SLNB contributes to reduce significantly the FNR of the latter from 18% to 0% (FNR for SLNB =18.5% vs FNR for TAD=0%). Potential changes in surgical (CLN+/SLNs-) and oncological management (CLN+/SLNs- and absence of residual tumor in breast) occurs in 15.1% (11/73) and 4.1% (3/73) of cases, respectively. References 1. Swarnkar PK et al. The Evolving Role of Marked Lymph Node Biopsy (MLNB) and Targeted Axillary Dissection (TAD) after Neoadjuvant Chemotherapy (NACT) for Node-Positive Breast Cancer: Systematic Review and Pooled Analysis. Cancers (Basel) 2021 Mar 26;13(7):1539. 2. Weiss A et al. How Often Does Retrieval of a Clipped Lymph Node Change Adjuvant Therapy Recommendations? A Prospective, Consecutive, Patient Cohort Study. 2022 Jun. Ann Surg Oncol 2022; 29(6): 3764-3771. Table 1: Clinicopathologic characteristics in the cN+ breast cancer patients NAC and clipped Lymph Node NAC Citation Format: Francesca Arienzo, Domenico Campagna, Paola Scavinia, Laura Broglia, Laura Broglia, Alessandra Ascarelli, Helena Colavito, Mirko Montanari, Elena Manna, Tiziana Mastropietro, Emanuele Zarba Meli, Massimo La Pinta, Daniela Musio, Mauro Minelli, Paola Scavina, Michelina Maria Carla Amato, Leopoldo Costarelli. Clipped lymph nodes for cN+ patients decrease false negative rate and lead to potential changes in surgical and oncological management after clinical complete response following neoadjuvant chemotherapy [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-07-27.
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CIARDI, MARCO. "VOLTIANA ALESSANDRO VOLTA, On the Electricity excited by the mere Contact of conducting Substances of different kinds. Bicentenary Edition in French, English, German and Italian of the Letter to Sir Joseph Banks of the 20th of March 2000, Milano, Hoepli, 1999, 102 pp., L. 10.000 (ISBN 88-203-2762-7). FABIO BEVILACQUA, LUCIO FREGONESE, Nuova Voltiana. Studies on Volta and his Times, Milano, Hoepli, 2000-2001, 3 voll., 1° vol., 157 pp., L. 30.000 (ISBN 88-203-2789-9); 2° voi., 113 pp., L. 30.000 (ISBN 88-203-2790-2); 3° voi., 151 pp. (ISBN 88-203-2791-0). GIANNI BONERA, PIERSANDRO VANZAN, Alessandro Volta: l'uomo, lo scienziato, il credente, Pavia, Edizioni CdG, 1999, 152 pp., L. 10.000. CARLO LINATI, Cupido fra gli alambicchi, Novara, Interlinea Edizioni, 2000, 124 pp." Nuncius 16, no. 1 (January 1, 2001): 454–55. http://dx.doi.org/10.1163/221058701x00347.
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Dumser, Elisha Ann. "New work on the Basilica of Maxentius - CARLO GIAVARINI (a cura di), LA BASILICA DI MASSENZIO. IL MONUMENTO, I MATERIALI, LE STRUTTURE, LA STABILITÀ (Studia Archaeologica 137; L'Erma di Bretschneider, Rome2005). Pp. 269, over 200 figs., many in color. ISBN 88-8265-319-6. EUR. 140. - CARLO GIAVARINI (ed.), THE BASILICA OF MAXENTIUS. THE MONUMENT, ITS MATERIALS, CONSTRUCTION, AND STABILITY (Studia Archaeologica 140; L'Erma di Bretschneider, Rome2005). Pp. 265, over 200 figs., many in color. ISBN 88-8265-359-5. EUR. 140. - ALESSANDRO CARÈ, L'ORNATO ARCHITETTONICO DELLA BASILICA DI MASSENZIO (Studia Archaeologica 138; L'Erma di Bretschneider, Rome2005). Pp. 308, pls. 128, figs. 7. ISBN 88-8265-331-5. EUR. 170." Journal of Roman Archaeology 20 (2007): 663–66. http://dx.doi.org/10.1017/s1047759400006127.
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Panigada, G., M. Campanini, A. Fontanella, and R. Nardi. "Aspetti clinico-organizzativi nella degenza medica ospedaliera in Italia: il ruolo della Medicina Interna nel Dipartimento Medico e continuità assistenziale." Italian Journal of Medicine 3, no. 1 (December 31, 2015): 499. http://dx.doi.org/10.4081/itjm.q.2015.6.
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<img src="/public/site/images/pgranata/intro.jpg" alt="" /><br /><p class="titolo"><strong>Aspetti clinico-organizzativi nella degenza medica ospedaliera in Italia: il ruolo della Medicina Interna nel dipartimento medico e continuità assistenziale</strong> 499<br /><em>G. Panigada, I. Chiti</em></p><img src="/public/site/images/pgranata/Sezioni3.jpg" alt="" /><br /><p class="titolo"><strong>Organizzazione delle Medicine Interne della Toscana: analisi specifica delle criticità</strong> 503<br /><em>R. Laureano, S. Meini</em></p><p class="titolo"><strong>Risultati di una <em>survey</em> sulla complessità promossa da FADOI</strong> 509<br /><em>M. Gambacorta, A. Montagnani, P. Gnerre</em></p><p class="titolo"><strong><em>Fare di più non significa fare meglio</em>: il contributo FADOI al programma di <em>Slow Medicine</em> per una medicina sostenibile</strong> 513<br /><em>L. Lusiani, R. Frediani, A. Fortini, R. Nardi</em></p><p class="titolo"><strong>Gli effetti della riorganizzazione ospedaliera sulla comunicazione medico-paziente: un’analisi di cambiamento necessario</strong> 523<br /><em>M. Felici, S. Lenti</em></p><p class="titolo"><strong>Survey sui fabbisogni di formazione e aggiornamento degli internisti FADOI</strong> 528<br /><em>C. Canale, M. Cannone, M. La Regina, R. Risicato, M. Silingardi</em></p><img src="/public/site/images/pgranata/Sezioni21.jpg" alt="" /> <br /><p class="titolo"><strong>L’internista ospedaliero: dentro o fuori?</strong> 531<br /><em>F. Orlandini, F. Pietrantonio</em></p><p class="titolo"><strong>La telemedicina in Medicina Interna</strong> 537<br /><em>A. Sciascera</em></p><p class="titolo"><strong><em>Red flags</em> e modelli di <em>fast track</em> per accedere rapidamente alla diagnosi precoce</strong> 541<br /><em>F. Pieralli, F. Corradi</em></p><img src="/public/site/images/pgranata/Sezioni4.jpg" alt="" /><br /><p class="titolo"><strong>Sovraffollamento e qualità assistenziale in Ospedale: sono previste soluzioni nei patti per la salute?</strong> 544<br /><em>A. Fontanella</em></p><p class="titolo"><strong>L’area critica di medicina interna: stato dell’arte nella Regione Puglia. Quali motivazioni? Per quali pazienti? Secondo quali normative?</strong> 548<br /><em>F. Ventrella</em></p><p class="titolo"><strong>Il <em>medico tutor</em> nell’ospedale per intensità di cura</strong> 556<br /><em>M. Alessandri</em></p><p class="titolo"><strong>L’<em>Hospitalist</em></strong> 563<br /><em>I. Stefani, A. Mazzone</em></p><p class="titolo"><strong>Il dipartimento medico è tuttora una soluzione per il governo clinico della complessità assistenziale?</strong> 567<br /><em>G. Landini</em></p><p class="titolo"><strong>Modalità organizzative e clima interno nell’area medica</strong> 569<br /><em>S. De Carli, R. Re</em></p><p class="titolo"><strong>Malattie endocrino-metaboliche in area medica: percorsi clinico-assistenziali ed implicazioni economiche</strong> 575<br /><em>M. Cappagli, S. Barbieri, V. Scardigli, C. Rossi, L. Sanna, E. Romano</em></p><p class="titolo"><strong>Cure palliative: nuova branca specialistica o competenze da riscoprire?</strong> 583<br /><em>G. Chesi, P. Montanari, R. Nardi</em></p><p class="titolo"><strong>Strumenti di comunicazione esterna per la continuità assistenziale: dimissioni protette, percorsi integrati ospedale territorio, integrazione di servizi</strong> 588<br /><em>G. Chesi, E. Scalabrini, N. Branchetti, C. Sarti, F. Bencivenni, A. Giudici</em></p><p class="titolo"><strong><em>Integrated delivery system</em>: effetti su costi e qualità. Quale futuro?</strong> 599<br /><em>E. Desideri</em></p><p class="titolo"><strong>L’ospedale del futuro tra assistenza in acuzie e continuità di cura: il modello inglese può essere implementato anche nei nostri ospedali?</strong> 601<br /><em>P. Gnerre, M. Gambacorta, A. Montagnani</em></p><img src="/public/site/images/pgranata/concl.jpg" alt="" /><p class="titolo"><strong>Conclusioni: chi garantisce il coordinamento e la continuità delle cure?</strong> 608<br /><em>C. Nozzoli</em></p><img src="/public/site/images/pgranata/appendix.jpg" alt="" /><br /><p class="titolo"><strong>I documenti FADOI</strong> 610<br /><em>M. Campanini</em></p>
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Parsons, Amy L. "Advertising & The Business of Brands: An Introduction to Careers & Concepts in Advertising & Marketing20113Bruce Bendinger, Ann Maxwell, Beth Barnes, Susan Alessandri, Elizabeth Tucker, Anthony McGann, Robert Gustafson, Marian Azzaro, Carla Lloyd, Laurence Minsky, Joe Marconi, Kevin Adler, Susan Jones, Jim Avery, Tom Fauls, Alice Kendrick, Joe Bob Hester, Dennis Ganahl, and James Marra. Advertising & The Business of Brands: An Introduction to Careers & Concepts in Advertising & Marketing. Chicago: The Copy Workshop 2009. 654 pp. (Paperback) www.adbuzz.com." Journal of Consumer Marketing 28, no. 5 (August 2, 2011): 387–88. http://dx.doi.org/10.1108/07363761111150053.
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Cavaleri, Piero, Michael Keren, Giovanni B. Ramello, and Vittorio Valli. "Publishing an E-Journal on a Shoe String: Is It a Sustainable Project?**We wish to thank a number of colleagues for helpful comments and suggestions. We are grateful among others, to the participants in the conference on ‘Open Societies vs. Intellectual Enclosures Innovation, Imitation and Economic Growth’ at the Università del Piemonte Orientale ‘Amedeo Avogadro’ in Alessandria, on 3-4 October, 2008 and in particular to Alberto Cassone, Stefano Fenoaltea, Brett Frischmann, Wendy Gordon, Carla Marchese, Keith Maskus and Francesco Silva. Usual disclaimers apply." Economic Analysis and Policy 39, no. 1 (March 2009): 89–102. http://dx.doi.org/10.1016/s0313-5926(09)50045-8.
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Gianezini, Prof Dr Miguelangelo, and Profa Dra Adriana Carvalho Pinto Vieira. "Apresentação." Desenvolvimento Socioeconômico em Debate 1, no. 2 (May 30, 2016): 1. http://dx.doi.org/10.18616/rdsd.v1i2.2401.
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<p>Editorial Após o lançamento do número inaugural a Revista Desenvolvimento Socioeconômico em Debate passou a ser divulgada junto à comunidade científica, tendo sido bem recebida, em especial pelo público que busca uma leitura interdisciplinar em temas relacionados ou correlacionados às políticas públicas e ao desenvolvimento socioeconômico. E tal repercussão nos encorajou a publicar um segundo número do volume 1 (2015), que inicialmente previa apenas um número por ano. Esta decisão é difícil e os editores de periódicos que já trilharam este caminho sabem que esta tarefa requer dedicação, apoio institucional e estímulos. Podemos dizer que desde o primeiro número nada disto nos faltou, em especial os estímulos que vieram por conta de algumas conquistas, a saber: obtivemos o International Standard Serial Number (ISSN 2446- 5496); adotamos novo lay-out e visual no portal de Periódico Unesc - http://periodicos.unesc.net/RDSD/index; fomos indexados em algumas bases de dados e diretórios de pesquisa e aguardamos retorno de mais 3 bases até o final de 2016; obtivemos igualmente a Licença Creative Commons 4.0 Internacional (versão mais recente); com apoio da Editora, fomos o primeiro periódico da Unesc a receber o Digital Object Identifier (DOI) e também o Crossref; alguns autores do primeiro número já incluíram o DOI na Plataforma Lattes e assim que informarem à Plataforma Sucupira, poderemos obter o Qualis para ingresso permanente no periódicos CAPES. Assim, a RDSD chega ao segundo número cumprindo de fato seu papel interdisciplinar e polivalente, reunindo sete novos manuscritos que abordam temas atuais e relevantes. O primeiro estudo Análise do crédito do PRONAF no estado de Goiás no período de 2000-2011 foi enviado pelos pesquisadores Gilberto José de Faria Queiroz, Divina Aparecida Leonel Lunas e Ozamir Alves Frias. O artigo aborda a questão da criação do Programa de Fortalecimento da Agricultura Familiar (Pronaf), considerado o principal instrumento da política agrícola brasileira para profissionalização e a inserção do agricultor familiar no mercado. O texto trata do marco legal da constituição da legislação do Pronaf e sua evolução em termos de número de contratos e volume de recursos disponibilizados. Foca, ainda, na questão da distribuição dos recursos para o Estado de Goiás, analisando a sua evolução nas modalidades de custeio, financiamento e total para o segmento agrícola e pecuário. A análise da evolução é feita para o período de 2000 a 2011, com dos dados coletados junto ao Banco Central do Brasil por meio do Anuário Estatístico do Crédito Rural. O segundo artigo é intitulado Indicações geográficas e a multifuncionalidade da agricultura enviado pelo pesquisador Valdinho Pellin. O artigo trata das Indicações Geográficas (IGs), que podem ser entendidas como uma estratégia de desenvolvimento a partir do momento que possibilita agregar valor a produtos ou serviços que tem características próprias relacionadas ao território ao qual estão inseridas. Podem representar também valorização das tradições locais associadas ao fortalecimento de uma identidade cultural própria. Pellin aponta que os principais desafios se relacionam a estruturação de arranjos institucionais que articulem de maneira eficiente os atores envolvidos; o alto custo financeiro para reconhecer e manter uma IG e o perigo da mercantilização dos processos produtivos, que coloca em risco a tipicidade dos produtos ligados à sua origem. O terceiro artigo é o Portal da Transparência e o acesso à informação: um estudo do portal da transparência e o controle social em três municípios do estado de Pernambuco de Alessandra Carla Ceolin, José Aldo Cavalcanti de Almeida e Maria do Carmo Maracajá Alves. Ele aborda o tema sobre a implementação da Lei de Acesso à Informação que tem como princípio atender ao Direito Público Administrativo, no tocante à publicidade, onde qualquer cidadão pode tomar ciência de fatos ocorridos nessa esfera. Assim, a facilidade de navegação nos portais corporativos é ponto significativo para atendimento desse princípio. É analisado o conteúdo e layout de apresentação das informações do site Portal da Transparência nos municípios pernambucanos de Recife, Olinda e Jaboatão dos Guararapes. Os resultados obtidos demonstram um visível atendimento às práticas e determinações do sistema de informação nos portais, para o alcance da eficiência e eficácia desejada ao que diz respeito às boas práticas da transparência e a accountability. O quarto artigo aborda Os paradigmas dominantes na gestão da educação superior a partir da autoavaliação: uma revisão integrativa e tem a autoria de Marina Keiko Nakayama, Jactania Marques Muller e Emílio da Silva Neto. O estudo apresenta a transformação substancial que a educação superior vem passando em seu modelo gerencial. Isso é causado, principalmente, pelas diversas lógicas dominantes que se encontram em cada contexto, orientando uma reflexão sistemática sobre sua estrutura gerencial e que se constitui a partir da autoavaliação. Sob esse pressuposto, o artigo promove uma reflexão acerca dessas mudanças, buscando um entendimento sobre os paradigmas que orientam a perspectiva gerencial na educação superior e as tendências que se apresentam para o segmento em nível mundial e no Brasil. Observa-se que enquanto em nível internacional a lógica predominante é a interpretativista, no Brasil, em função da forte influência da lógica mercantil na educação superior, há uma tendência funcionalista, somativa e regulatória, fortalecendo o controle do estado no contexto deste nível educacional. O quinto artigo é intitulado Migrações e urbanização em Santa Catarina de Juliano Giassi Goularti. O objetivo do trabalho foi discutir as migrações no Estado de Santa Catarina nas últimas décadas. Com base nos dados disponibilizados pelo Censo/IBGE (1940-2010), o autor relaciona o aumento das migrações com o processo de urbanização e o surgimento da problemática urbana, como por exemplo, a violência. Pelos dados, verifica-se que as cidades que apresentam um maior grau de complexidade industrial como Joinville, Blumenau, Florianópolis, Itajaí, Chapecó e seu hinterland são as mais procuradas pelos migrantes e as que mais tiveram crescimento de sua população muito acima da média estadual. Por outro lado, aponta o pesquisador, as cidades com menor grau de desenvolvimento perderam população residente. O sexto artigo é sobre a Responsabilidade Social Empresarial e Economia Solidária: a Construção Social da Empresa no Brasil, de Caroline da Graça Jacques, Melissa Gabriela Barcelos e Maria Soledad Etcheverry Orchard, O artigo expõe algumas das transformações que atingem o setor empresarial contemporâneo em sua busca por legitimidade junto a setores da sociedade brasileira. Foi questionado pelos autores se os programas de Responsabilidade Social Empresarial (RSE) indicam lógicas diferentes da busca pela maximização dos lucros corporativos. Como forma de ilustrar esse debate, os autores realizaram um estudo de caso no Instituto Consulado da Mulher, criado pela marca Consul de Eletrodomésticos para o cenário sociopolítico brasileiro. A abordagem sociológica dos mercados e das empresas, que ressalta as dimensões social, cultural e política da ação econômica indica que as empresas são construções sociais. Nesse sentido, pode-se compreender a RSE e suas singularidades no contexto nacional pela emergência de políticas sociais liberais. </p><p>O sétimo artigo tem como título um questionamento: As bandeiras de conveniência: o ovo ou a galinha dos paraísos fiscais? Nele o autor, Jose Antonio Mateo Oviedo demonstra que o sistema de negócios cada vez mais utilizado pela marinha mercante do mundo é o uso de bandeiras de países que diferem das de residência do proprietário. Esta prática permite o anonimato jurídico do proprietário e benefícios sindical, fiscais e segurança dos navios. Os países mais proeminentes (mais de 30) que tem permitido o registro dos navios ao abrigo deste regime são o Panamá, Libéria e as Ilhas Marshall. O Autor comenta que enquanto o recurso não é ilegal e é fundado na soberania nacional, a sua legitimidade é no mínimo questionável. Com isso ele analisa o impacto na atualidade deste procedimento na frota mercante mundial e depois mede e avalia o uso em um porto específico. O artigo analisa criticamente os relatórios e estatísticas a esse respeito, oriundos da Federação Internacional dos Transportes (ITF) e da Conferência das Nações Unidas sobre o comércio e o Desenvolvimento (UNCTAD), além de informações detalhadas da alfândega e polícia portuária de Porto Quequén entre 1922 e 2012. A análise conclui que este procedimento não para de crescer desde a década de 1990 e ainda tem aumentado, apesar da pregação por boas práticas na navegação e as queixas da comunidade de trabalhadores embarcados. Em conclusão a este segundo editorial, reiteramos nossos agradecimentos a todos os envolvidos na concretização deste projeto, com destaque para os colaboradores da Editora da UNESC, os membros do Conselho Editorial, revisores cadastrados e é claro, aos pesquisadores que escolheram a RDSD como canal para divulgação de seus estudos. Desejamos a todos uma boa leitura e reflexões para futuras pesquisas.</p>
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Sousa, Sandra Novais, Simone Albuquerque da Rocha, Marli Amélia Lucas de Oliveira, and Maria Joselma do Nascimento Franco. "Necessidades formativas de professores iniciantes na educação básica: conceitos, concepções e revisão de literatura (Training needs of beginning teachers in basic education: concepts, conceptions and literature review)." Revista Eletrônica de Educação 14 (October 9, 2020): 4175116. http://dx.doi.org/10.14244/198271994175.
Full textAbstract:
e4175116Abstract The article aims at bringing to the debate the polysemy of the concept of training needs and the relation between the conceptions of teacher education and the instruments used to map or diagnose these needs. Prompted by the following inquiries: what has been provided as theoretical references on training needs to researchers of the theme? What concepts of training needs, and based on what conceptions of teacher education, are presented in 10 years of production on the theme in the national scenario? What are the comprehensions of these researchers about the training needs of beginning teachers in basic education? For this, as methodological procedures, first it were conducted studies of theorists who could contribute for the comprehension of the object, followed by the analysis of articles, theses and dissertations available in data bases, selected through the criterions listed in a protocol of systematic review. The results show that the productions of theorists adopted for the comprehension of concepts about training needs contributed for deepening knowledge on the object. The systematic literature review pointed out the absence of the conception of the term training needs in most of the analyzed productions, as well as the prevalence of an understanding of need as lack of knowledge resulting from the initial teacher education and linked to the challenges and personal tensions of the daily routine of the profession and of the period of initiation. The results also show the pertinence of the constitution of collaborative training environments, as well as of the elaboration, by the school networks, of induction programs.ResumoO artigo apresenta como objetivo trazer ao debate a polissemia do conceito de necessidades formativas e a relação entre as concepções de formação e os instrumentos utilizados para fazer o levantamento ou diagnóstico dessas necessidades. Partiu-se dos seguintes questionamentos: o que se tem disponibilizado enquanto referenciais teóricos sobre necessidades formativas a pesquisadores do tema? Quais conceitos de necessidades formativas, e baseados em quais concepções de formação, são apresentados em dez anos de produção sobre o tema no cenário nacional? Quais as compreensões desses pesquisadores sobre as necessidades formativas de professores iniciantes na educação básica? Para tanto, como procedimentos metodológicos, realizou-se primeiramente estudos de teóricos que pudessem contribuir para a compreensão do objeto, seguido da análise de artigos, dissertações e teses disponibilizados em bases de dados, selecionados a partir de critérios elencados em um protocolo de revisão sistemática. Como resultados, aponta-se que as produções de teóricos adotadas para a compreensão de conceitos sobre necessidades formativas contribuíram para aprofundar conhecimentos sobre o objeto. A revisão sistemática de literatura apontou a ausência da conceituação do termo necessidades formativas na maioria das produções analisadas, bem como a prevalência de um entendimento de necessidade como falta de conhecimentos advindos da formação inicial e ligados aos desafios e tensões próprias do cotidiano da profissão e do período de iniciação. Os resultados mostram também, a pertinência da constituição de espaços formativos colaborativos, bem como da elaboração, pelas redes de ensino, de programas de indução.Palavras-chave: Iniciação de professores, Levantamento de necessidades, Pesquisa educacional, Revisão de literatura.Keywords: Beginners, Training needs, Educacional research, Literature reviews.ReferencesAFANASIEV, Viktor Griegorievich. Fundamentos da Filosofia. Rio de Janeiro: Civilização Brasileira, 1968.BANDEIRA, Hilda Maria Martins. Necessidades formativas de professores iniciantes na produção da práxis: realidade e possibilidades. 2014. 248 f. 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Andrade, Alexandre de Melo, and Paloma Batista Cardoso. "Apresentação - nº 25." Travessias Interativas, no. 25 (June 30, 2022): 6–10. http://dx.doi.org/10.51951/ti.v12i25.p6-10.
Full textAbstract:
DOSSIÊ:FLUXO CONTÍNUO
APRESENTAÇÃO
O número 25 da revista Travessias Interativas traz artigos de diversas vertentes de estudos Linguísticos e Literários, que apresentam contribuições relevantes sobre aspectos lexicais, pedagógicos, discursivos, socioculturais e filosóficos. O presente volume está dividido em quatro seções. As duas primeiras apresentam estudos das duas grandes áreas dos Estudos da Linguagem: Estudos Linguísticos e Estudos Literários; a terceira apresenta estudos desenvolvidos por alunos do Programa Institucional de Bolsas de Iniciação Científica (PIBIC); e a quarta, entrevistas com dois grandes pesquisadores do ensino de línguas: Anne-Marie Chartier e Artur Gomes de Morais.
A seção de Estudos Linguísticos é iniciada pelo texto da autoria de Andrêssa de Oliveira Andrade e Vanessa Regina Duarte Xavier, intitulado Neologismos em tuites de grandes empresas: uma análise lexicultural. Nesse trabalho, as autoras mostram como, no ambiente virtual, a interação entre falantes proporciona inovações semânticas em itens lexicais pré-existentes, a fim de destacar o posicionamento de um falante/empresa em relação ao seu ouvinte/cliente. A análise do posicionamento de um falante em relação ao outro também está presente em Atenuadores em introduções de artigos acadêmicos da área da administração pública, de Roberto Carlos Ribeiro Araújo. Este autor aponta como o uso de expressões epistêmicas é relevante para a negociação do conhecimento científico veiculado em artigos acadêmicos e para o delineamento da posição assumida por cientistas perante seus pares.
Os artigos seguintes discutem a relevância do letramento verbal e visual na escola e fora dela. Em Letramento visual e o gênero notícia em livro didático, Paulo Vitor Melo e Carina Aparecida Lima de Souza defendem um ensino que leve em consideração o fato de que a compreensão de textos também é influenciada pelo que é visto. Em todos os artigos que apontam a relevância do letramento publicados no presente número da Travessias Interativas, defende-se que é impossível pensar em letramento sem levar em consideração as particularidades de cada gênero textual e do contexto sócio-histórico em que ele é produzido. Em Letramentos e desinfodema: o leitor modelo do serviço de checagem de fatos “saúde sem fake News”, Augusto Vinicius de Oliveira e Fabiana Komesu discutem as habilidades específicas que um leitor deve ter desenvolvido para ler textos que reportam dados científicos.
O leitor que lida com textos divulgados na internet utiliza ferramentas específicas para ajudar na compreensão de vocabulário: dicionários eletrônicos que, conforme sugere Lílian Thais de Jesus, em A estrutura e os recursos dos dicionários gerais on-line de língua portuguesa, fazem uso de remissões e links de retomada de informações, estratégia importante para o leitor moderno.
No ambiente virtual, há um grande volume de dados que pode ser localizado em poucos segundos, por meio de palavras-chave adequadas e/ou que sejam frequentes em determinada área do conhecimento. Giselle Liana Fetter, em Teoria Dialógica do Discurso (TDD) e pesquisa com grandes corpora: processo de composição de discursos sobre a divulgação científica, sugere que a busca automatizada desses itens lexicais, além de facilitar a compilação de dados, permite que se analise o modo como a divulgação científica é enxergado pela sociedade, o que é relevante para o desenvolvimento de estratégias cujo objetivo seja alcançar o maior número de leitores possível.
Além da discussão sobre a expressão do posicionamento dos falantes a partir de usos linguísticos específicos, materiais para o ensino de língua portuguesa como língua materna e o uso de ferramentas computacionais para compreensão de vocabulário e busca de itens lexicais, o volume 25 da Travessias Iterativas também traz artigos que discutem as concepções de ensino de língua portuguesa para falantes não-nativos. Em uma realidade marcada pelo contato entre o português falado por nativos brasileiros e por falantes advindos de regiões em situação de crise, Carla Alessandra Couto, em Português como língua de acolhimento pelas vozes de migrantes de crise, defende que o ensino de língua portuguesa deve ser um instrumento de acolhida de pessoas e das suas identidades. Para que isso aconteça, segundo Isis Ribeiro Berger, em As línguas e seus lugares nas fronteiras: desafios da formação de professores em contextos multilíngues, é necessário que se tenha uma formação de professores sensível à influência, na aprendizagem e nos usos linguísticos, da mobilidade populacional, especialmente em regiões de fronteira nacional.
Em uma abordagem discursiva, Alex Bezerra Leitão, em Autismo e metáforas multimodais: impacto discursivo de ações e de concepções capacitistas, discute como o uso de elementos verbais e não-verbais na construção de metáforas evidencia o posicionamento de falantes acerca de pessoas autistas, que continuam sendo enxergadas como “pessoas de fora”.
O modo como um grupo específico é enxergado e como sujeitos e lugares são constituídos é o foco do artigo de Alex Bezerra Leitão e dos demais capítulos da seção de Estudos Linguísticos. Em A condição heterogênea da formação discursiva e a fragmentação da forma-sujeito: um sujeito “dividido” entre as questões ideológicas e a ciência, Rubiamara Pasinatto discorre sobre o modo como os usos linguísticos dos falantes evidenciam diferentes formas-sujeito. A constituição da imagem do sujeito também é a questão central do artigo de Raimundo Romão Batista, intitulado Uma imagem de influência mundial: os ethe discursivos de Joe Biden no discurso da vitória da eleição presencial de 2020. Neste texto, o autor descreve as estratégias de persuasão utilizadas pelo presidente estadunidense para convencer seus ouvintes de que a escolha dele para a presidência dos Estados Unidos foi acertada. Além da construção da imagem de sujeitos históricos, neste volume discute-se também a construção da historicidade de lugares e de conceitos amplamente arraigados na sociedade, como o de “lar”.
Para Ana Beatriz Ferreira Dias e Rafaela Oppermann Miranda, em O discurso fundador na construção de narrativas em Cerro Largo (RS): uma leitura de nomes de ruas, a escolha dos nomes de ruas em Cerro Largo (RS) revela a ideologia dominante naquela região, atravessada pela importância da valorização de uma cultura específica: a alemã. A(s) ideologia(s) que atravessa(m) a sociedade é evidenciada pelos efeitos de sentido que uma expressão carrega. Em Os efeitos de sentido do “lar” no contexto de isolamento social e as relações de gênero numa propaganda de cerveja, último artigo da seção de Estudos Linguísticos, Maria Alice Costa da Cilva e Claudiana Narzetti, a partir da análise da materialidade linguística presente em uma propaganda de certeja, pontuam transformações na concepção do gênero feminino na sociedade brasileira: a mulher, mesmo que ainda concebida em uma concepção binária já não é vista como a única responsável pelo funcionamento do lar.
Na seção de Estudos Literários, gênero e o universo feminino passam ser discutidos sob a ótica da composição artística e/ou pelo debate em torno do feminismo. O primeiro artigo – Da idealização à misoginia: O retrato da mulher satirizada em Cantigas de D. Afonso X e na pintura do século XVI –, da autoria de Nágela Alves da Costa e Clarice Zamanaro Cortez, trata das concepções femininas nos períodos medieval e renascentista, pala perspectiva da literatura e da pintura, e suas transformações sob o olhar do artista. Em A imposição da maternidade e o fracasso feminino na Nigéria moderna em Fique Comigo (2017), de Ayòbámi Adébáyò, Danielle Fabrício dos Santos e Elis Regina Fernandes Alves mostram a necessidade de discussão sobre o feminismo negro através do estudo da referida obra.
Os artigos seguintes conduzem a discussão para um âmbito maior, levando em conta sistemas de opressão instaurados nas sociedades modernas. Antônio Coutinho Soares Filho e Luíza Helena Oliveira da Silva, no artigo Os nervos do esqueleto: Interações humanas na peça A Invasão, de Dias Gomes, estudam as relações intersubjetivas e aspectos do Percurso Gerativo de Sentido na peça citada no título; a análise sociossemiótica comprova a crítica ao sistema opressivo a que a população está submetida. Paulo César S. Oliveira, por seu turno, faz uma leitura crítica das relações entre mobilidade e clausura no texto Pátria, de Bernardo Carvalho: Violência e Deslocamento no teatro do mundo, percebendo de que modo o autor ficcionaliza questões políticas e ideológicas da atualidade. Na sequência, em Diálogos interculturais em Nada digo de ti que em ti não veja, Roberta Tiburcio Barbosa se debruça sobre o romance de Eliana Alves, com vistas a demonstrar os sistemas de opressão e a afirmação das subjetividades negras.
As relações entre literatura e filosofia são contempladas nos próximos artigos. Em Vida e Proezas de Aléxis Zorbás: O caosmo de Nikos Kazantzákis?, João Victor Rodrigues Santos trata da relação entre as duas áreas, de modo mais genérico, e dos reflexos nietzschianos na obra do escritor grego, em específico. Arthur Katrein Moura, no seu texto Uma aventura solitária: O legado filosófico em Júbilo, Memória, Noviciado da paixão, de Hilda Hilst, analisa a relação que esta obra hilstiana estabelece com a filosofia, por intermédio da solidão e da consciência do “outro”. Dialogando a poesia com a filosofia, especialmente aquela filiada à tradição renascentista, Jânio Vieira dos Santos é autor do próximo artigo: Um recorte poético e filosófico em Alma Vênus, de Marco Lucchesi.
No artigo que aparece na sequência – “Sufocado em terra estrangeira”: Identidade e migração em Cinzas do Norte, de Milton Hatoum –, Felipe Dantas da Silva e André Tessaro Pelinser analisam o referido romance contemporâneo, entendendo sua relação com o regionalismo mais tradicional e suas transfigurações nas últimas décadas. Já o estudo do romance romântico Amor de Perdição, com análise minuciosa do narrador, surge na sequência, em Análise do narrador de Amor de Perdição, de Camilo Castelo Branco, de João Paulo Wizniewsky Amaral.
Abordagens críticas de poetas estão no centro dos próximos artigos. Em Da janela à sepultura: Encontros de Romeu e Julieta apropriados por Álvares de Azevedo, Alexandre Silva da Paixão analisa as menções feitas pelo escritor romântico brasileiro ao clássico shakespeariano, passando por teorias da literatura comparada (apropriação, comparatismo e recepção) e desvelando aspectos da escrita poética de Álvares de Azevedo. Já o artigo Um cavalo na minha paisagem: O sujeito lírico que se desloca para a morte do outro, de Iverton Gessé Ribeiro Gonçalves, apresenta uma leitura do poema “Cavalo Morto”, de Cecília Meireles, para compreender a relação entre sujeito e paisagem na experiência de morte. Katherine de Albuquerque Mendonça, em As pistas da contracultura na poesia de Mário Jorge, centra sua atenção nos elementos da contracultura identificados no poeta sergipano Mário Jorge, contribuindo, inclusive, para a divulgação da obra deste poeta, ainda pouco lido e reconhecido pela crítica.
Esta seção é finalizada com o artigo Romantismo na província: A recepção dos discursos românticos na imprensa piauiense, de Pedro Henrique de Sousa Moreira e Natália Gonçalves de Souza Santos. O texto investiga a recepção dos românticos na imprensa de Piauí e as relações daí estabelecidas com a Corte e com a própria província.
Na seção seguinte, de artigos de iniciação científica, há o texto O elo literário-filosófico vergiliano em Aparição (1971), de Débora Mendes dos Santos Alves, que discute as relações do romance Aparição, de Vergílio Ferreira, com alguns pressupostos da filosofia existencialista.
Apesar das diferenças de perspectivas e de abordagens, os trabalhos publicados neste volume da Travessias Interativas dialogam entre si, pois evidenciam o caráter mutável e, consequentemente, sócio-histórico da língua, visível tanto nos usos linguísticos quanto na construção de concepções e de identidades em textos artísticos e não-artísticos, elementos relevantes para todas as áreas dos Estudos da Linguagem.
Alexandre de Melo AndradeUFS
Paloma Batista CardosoUFS